HE431/BI416 – Pathophysiology
Course Outline - Fall, 2014
Course description:
Pathophysiology is the study of functional changes in cells, tissues, and organs as a result of disease
and/or injury. In this course we will build upon the knowledge base acquired in undergraduate human
physiology and/or comparative physiology courses to examine the underlying mechanisms of various
disorders in the organs and systems of the body including the cardiovascular, respiratory, digestive,
excretory, nervous, endocrine, skeletal-muscle, and reproductive systems. Examples of specific
disorders to be addressed in lecture may include inflammation, hypertension, coronary artery disease,
myocardial infarction, cerebral vascular accident, concussion, asthma, respiratory distress syndrome,
sudden infant death syndrome, gastritis, hepatitis, pancreatitis, dysentery, as well as shock, and other
multi-organ conditions arising from environmental stress (e.g. adaptive responses).
Course Instructor: Dr. Cristina Gheorghiu
Office Hours: by appointment only. You can also contact me by email: cgheorghiu@wlu.ca
Required Text:
Pathophysiology, 5th Edition (2014), by Lee-Ellen C. Copstead-Kirkhorn, PhD, RN and Jacquelyn L.
Banasik, PhD, ARNP , ISBN: 978-1-4557-2650-9, Elsevier.
Lectures will generally follow this required text, but students will only be responsible for material
presented in lectures.
Schedule:
Lectures:
MWF: 9:30 - 10:20 am
Science Building N1057
Evaluation*: Midterm exam 1 (50 min)
Midterm exam 2 (50 min)
Research project (30%)
Research Paper
Research Seminar
Class participation
35%
35%
15%
10%
5%
--------100%
TOTAL
*This is the proposed grading scheme, which may change at the discretion of the course instructor.
Midterm exams 1 will be written in class time and will cover LECTURES 1 - 13.
Midterm exams 2 will be written in class time and will cover LECTURES 16 - 24.
1
Tentative Lecture schedule
Lecture
Topic
Textbook Chapter
Sept. 5, 8
Introduction to Pathophysiology
Ch. 1
Sept. 10, 12
Homeostasis and Adaptive Responses to Stressors
Ch. 2
Sept. 15
Pain
Ch. 47
Sept. 17, 19
Cell Injury, Aging, and Death
Ch. 3, 4
Sept. 22, 24
Neoplasia
Ch. 7
Sept. 26, 29
Inflammation & Immunity
Ch. 9
Oct. 1, 3
Alterations in Immune Function
Ch.10, 11
Oct. 6
Review
Oct. 8
Midterm I (in class)
Oct. 10, 20, 22
Blood Disorders
Ch. 13, 14, 15, 16
Oct. 24, 27
Alterations in Cardiac Function
Ch. 18, 19, 20
Oct. 29, 31
Alterations in Gas Exchange
Ch. 22, 23
Nov. 3, 5
Alterations in Urinary Function
Ch. 27, 28, 29
Nov. 7, 10, 12, 14,
17, 19, 21, 24, 26,
28
Student Research Seminar
Dec. 1
Review
Dec. 3
Midterm II (in class) / TERM PAPER DUE
* This proposed lecture schedule may change at the discretion of the course instructor.
Attendance is expected for all classes. To reschedule a midterm, and/or your seminar, or to extend the
deadline for the research project, you must have a valid excuse (emergency, illness, etc.) and provide
applicable documentation as requested by the instructor. Please note that travel plans (except for
emergency travel or university-related travel) do not constitute an acceptable excuse to miss or
reschedule course work.
2
Research project. Students will also complete a major project in which they present a seminar and
submit an accompanying paper on the pathophysiology of a disease that was NOT covered during
lectures. As source of your research paper, please use peer-reviewed journal papers. There is flexibility
in determining your topic, but the topic MUST have instructor approval by October 10, 2014. If you
fail to choose a topic and have the instructor’s approval by October 10, 2014, you will have 1%
deducted from the weight of the research paper (15%). It is desirable that each student chose a
different topic. Possible topics and guidelines for the seminars and term paper will be provided at a
later date. Your PAPER will be a maximum of five (5) word-processed pages (not including references
or figures/tables), double-spaced, Time New Roman, size 12 font, organized using headings to
structure the main body of the text, as follows: Title page, Abstract, Introduction, Etiology,
Pathogenesis, Clinical manifestation, Prevention, Conclusion, References, Tables, List of figures and
figures. The grade for the paper will include the following criteria: originality and relevance of the
topic; thorough understanding of the cited papers; clarity of presentation; organization of the
presentation in an easy to follow/understood format. Your paper will be submitted using MyLS and
will be due by December 3, 2014, by 11:30 pm. Late research projects will have 5% deducted per day
of delay late, for no more than 7 days (including weekend days). After that, the paper will no longer be
accepted. The SEMINAR will be 8 minutes in length plus 2 minutes for questions, and will be given
during the last 3 weeks of November during the lecture period, before your paper submission. Students
will formally evaluate and provide feedback to all speakers; however the instructor will determine the
grade ultimately assigned for each seminar.
3
IMPORTANT NOTES
Adding and Dropping
Important Dates for Course Adding/Dropping and Tuition charges for the Fall 2014 Term, please see this link:
http://www.wlu.ca/calendars/dates.php?cal=1&t=210&y=61
Important Dates for Course Adding/Dropping and Tuition charges for the Winter 2015 Term, please see this link:
http://www.wlu.ca/calendars/dates.php?cal=1&t=211&y=61
Examination Deferrals
The Academic Date section of the Calendar (Printed and Web Site Versions) clearly states the examination date period for each semester. Students
must note that they are required to reserve this time in their personal calendars for the examinations. The Fall examination period is: December 619, 2014. The Winter examination period is: April 9-28, 2015. Students who are considering registering to write MCAT, LSAT or GMAT or a similar
examination, should select a time for those examinations that occurs outside the University examination period. For additional information that
describes the special circumstances for examination deferment, please check the following web page:
http://www.wlu.ca/page.php?grp_id=1&p=17294 – Faculty of Science: Request for Deferred Final Examination.
Student Awareness of Accessible Learning Centre
Students with disabilities or special needs are advised to contact Laurier’s Accessible Learning Centre for information regarding its services and
resources, ext. 3086. Students are encouraged to review the Calendar for information regarding all services available on campus.
http://waterloo.mylaurier.ca/accessible/info/home.htm
Academic and Research Misconduct
Academic misconduct is an act by a student, or by students working on a team project, which may result in a false evaluation of the student(s), or
which represents a deliberate attempt to unfairly gain an academic advantage. For detailed information on Academic Misconduct please refer to:
http://www.wlu.ca/page.php?grp_id=2505&p=11452
Plagiarism Detection Software
Wilfrid Laurier University uses software that can check for plagiarism. Students may be required to submit their written work in electronic form
and have it checked for plagiarism.
Learning Services
There is a range of academic learning support services offered at Laurier designed for all students who want to improve their academic
achievement in the classroom. These services include the following specific areas:
* Central Academic Advising Office
* Mathematics Assistance Centre
* Study Skills and Supplemental Instruction Centre
* Writing Centre
Please access the following web page for detailed information: (www.wlu.ca/learningservices)
Laurier Email Account
Our official means of communication is with your Laurier email account. Students are expected to regularly check their Laurier email account for
important notices from the university community. Students are also expected to send emails to official members of the university community from
their Laurier email account in order to ensure delivery. Emails sent from non-Laurier accounts, such as hotmail, may be identified as spam and not
delivered. Your co-operation is appreciated.