APPEARANCE AND PERFORMANCE ENHANCING DRUG USE SCHEDULE Version 1.1: 1-25-2010 Tom Hildebrandt, PsyD & James W. Langenbucher, PhD 1 Background and Definition Appearance and Performance Enhancing Drug (APED) use is a complex form of substance use that typically includes muscle building, fat burning/weight loss, and energy/endurance boosting substances. It is goal-directed, aimed to change physiological or psychological states relevant to individual appearance and performance related goals, and typically includes both benefits as well as a number of potential side effects. There are a wide range of potential substances that may be taken for appearance or performance enhancing purposes. These substances are usually taken in relatively predictable patterns with several drug classes being the most frequently encountered. These drug classes include anabolicandrogenic steroids, over-the-counter thermogenics/weight-loss supplements, over-the-counter muscle building supplements, and illicit ergo/thermogenics. APED Cycle: An APED cycle is the cornerstone phenomenon of APED use although few if any users will use the acronym “APED”. The cycle is typical referred to as an “anabolic cycle” or referenced by the specific goal such as a “bulking cycle” or “cutting cycle”. Many will refer to distinct periods of time as either “on-cycle” or “off-cycle”. These periods will vary in time from person to person, but “on-cycle” periods typically span 12-16 weeks and the “off-cycle” period begins as the APEDs start to leave the body (typically beginning about 2 weeks after the last dose of an APED. The “off-cycle” time is sometimes associated with what users refer to as a “post-cycle” crash. In attempts to avoid or prevent this “crash,” male users may use drugs like human chorionic gonadatropin (HCG) or low doses of testosterone to keep testosterone within a normal range. In some cases, users may stay on a lose dose of testosterone between cycles, a phenomenon called “bridging”. When a user stays on a low-dose chronically, he/she may conceptualize this as a form of hormone replacement therapy (HRT; for males) or an attempt to maximize health. Despite this practice, a user will still be able to identify alterations from this bridge or HRT as a cycle. During this period of “on-cycle” drug use, APED users will take a range of drugs, “stacking” them in specific order, dose, and duration. The types of drugs (described below) have different properties and functions, but generally they are taken for the purposes of maximizing lean muscle mass, reducing body fat, or in most cases both increasing muscle mass and decreasing fat. AAS: AASs constitute a majority of APEDs used with the most popular forms being testosterone (“Test”), trenbolone acetate (“Tren”), stanozolol (“Winny” or “Win-V”), nandrolone decanoate (Deca-Durabolin, "Deca," "Nan"), methandrostenolone (Dianabol, "Dbol"), methyltestosterone, oxandrolone, and oxymetholone (“Anavar”). All synthetic and endogenous androgens are four-ringed structures with 19 carbon atoms, but AAS generally consist of modified testosterone molecules. The chemical structure of these synthetic androgens differs in several important ways. For example, many AASs represent testosterone molecules modified by 17α-alkylation, where a methyl group (CH3) is added at the C17α position. This process slows hepatic inactivation and allows for these AAS to become active through oral administration. Such modifications are seen in a range of AASs including methyltestosterone, oxandrolone, oxymetholone, and stanozolol. A second, equally important modification to the chemical structure of testosterone, is the 17β-estrification of the 17-hydroxy group with a chain of hydrocarbon molecules. This process allows esters of different lengths to be added to the testosterone molecule, which slow the metabolism of the molecule to biologically inactive keto 2 steroids. Finally, a third modification includes both esterification and substituting hydrogen for the methyl group at C19, which further extends the half-life of the molecule. Although these methods are the most common alterations to the testosterone molecule, more than 100 synthetic steroids have been developed. Biological Activity. The body naturally produces C19 steroid hormones (known as the androgens) through a series of biotransformations primarily taking place in the gonads, where pregnenolone is eventually converted into testosterone and androstenedione through cleavage of the ethyl group from a progestin precursor at C17. These androgens are produced in the Leydig cells of the testes, while Sertoli cells produce the androgen-binding proteins that carry androgens through the blood and able to cross the blood-brain barrier. Endogenous as well as synthetic androgens exert the majority of their biological activity through androgen receptors, which are spread widely throughout the mammalian body with the highest concentrations being in the reproductive tissue (e.g., gonads) and nonreproductive tissues such as the kidneys, liver, muscles, brain, and bone. In addition to direct activation of androgen receptors by AASs, these hormones are also subject to different metabolic processes. Testosterone breaks down into several metabolites including dihydrotestosterone (DHT) and estradiol (E2). The biotransformation of testosterone into these molecules is a result of enzymatic activity of 5α-reductase and aromatase respectively. These enzymes have different concentrations across different areas of the body. Of most relevance, these enzymes have differential concentrations in relevant brain regions. These metabolites are also responsible for the effects of AAS. For instance, DHT is responsible for much of the androgenic or virulizing effects of AAS and is associated with particularly high concentrations in the prostate. Conversely, E2 is an estrogen with higher activity found in bone and breast tissues and there is some evidence that this metabolite is associated with aggression in male mice, although this may be related to amount of E2 receptors in the brain. Non-Steroidal Anabolics: There are at least three primary non-steroidal anabolics that are used by APED users, although non-steroidal anabolics are used only by a small percentage of users. These substances include insulin (“slin”), insulin-like growth hormone (IGF), and human growth hormone (HGH). All three substances are produced by the human body and have legitimate medical uses. Ergo/thermogenics: Ergogenic, thermogenic, and anorexigent compounds are typically used to increase energy, boost metabolism, raise body temperature, reduce appetite, and “burn fat.” These substance fall into three basic categories (a) xanthines - caffeine, theophylline, and theobromine; (b) sympathomimetics - such as ephedrine and ephedra; and (c) thyroid hormones - mainly Cytomel or T3. All three categories work as central nervous stimulants (CNS) with the latter category requiring a prescription for legal use. Other substances that may be used by some APED users include dinitrophenol (DNP) which is a protein uncoupler and will increase internal body temperatures, and eyrthropotein (EPO) which stimulates red blood cell production and is used for increased endurance. Over-the-Counter Ergo/Thermogenics: These substances are typically sold in the form of fat burning or performance enhancing nutritional supplements. Popular forms of these supplements will often stack xanthenes with a sympathomimetic (e.g., caffeine + ephedra) in order to maximize CNS effects. Almost all APED users will include these substances as part of an APED cycle, although the duration of use may be constant rather than cycled with some users. The side effects of these drugs are more clearly linked to aggression, irritability, and 3 anger than AASs and are likely to play some significant role in the reported psychological effects of the APED cycle. The most common ingredient in OTC ergo/thermogenics (caffeine) acts as a stimulant by disabling the inhibitory effects of adenosine in the central nervous system. The blockade of adenosine receptors by caffeine results in increased concentrations of several cerebral neurotransmitters including serotonin, dopamine, acetylcholine, norepinephrine, and glutamate, which in turn cause increased spontaneous neuronal firing and also activates the peripheral nervous system. Thus, an individual taking high amounts of this substance will achieve a higher overall level of arousal which may lead to increased ability to attend to different stimuli in the environment and improve cognitive performance. Similarly, the stimulant properties will allow someone who is otherwise fatigued to continue to train and ultimately increase the productivity of their physical output. Finally, caffeine and other xanthenes will also decrease appetite and increase the likelihood of sticking to a restrictive caloric diet. Sympathomimetic drugs are similar in structure and action (hence being called mimics) to epinephrine and norepinephrine in the sympathetic nervous system. Ephedrine, norephedrine, ephedra, Ma Huang, phenylpropanolamine (PPA), and pseudoephedrine are all substances in this category. Ephedrine, pseudoephedrine, PPA, and herbal preparations containing ephedra and Ma Huang have until recently been easily available over the counter and present in a number of herbal supplements. However, in November 2000, after a study found that the use of PPA caused an increased risk of strokes, the United States Food and Drug Administration released a health advisory and requested that all manufacturers discontinue marketing products containing PPA (FDA/Center for Drug Evaluation and Research, 2000). Although it is still available for some uses, it is no longer easily available over-the-counter. Ephedra has undergone similar legislative restriction, being placed on the FDA banned list as an herbal supplement with all legal sales ending in 2004. Similar substances have been developed to get around these restrictions, which reflects the rapidly evolving market. Ephedrine’s primary mechanism of action is through activation of the betaandronergic receptors of muscle tissue which increase metabolic output and ultimately increases the likelihood of burning fat. Illicit Ergo/Thermogenics: The thyroide hormones (T3 and T4) require a prescription for legal use. The most common hormone used is triiodothyronine (T3 or liothyronine). It is available in a synthetic preparation as Cytomel or combined with thyroxine (T4) as Thyrolar. T3 is only available by prescription in the United States. Synthetic thyroxine (T4) by itself is also available and is more frequently prescribed for thyroid disease. Thyroxine (T4) must be converted to T3 in order to be metabolically active and so it is often prescribed by itself for hypothyroidism since it is somewhat safer due to the brain’s ability to autoregulate the conversion from T4 to T3. The most well known action of thyroid hormones is thermogenesis, which is believed to result from effects of these hormones either on mitochondrial metabolism or on transport of sodium and potassium across cellular membranes. As described earlier, other substances potentially used by APED users include EPO and DNP, which have their own unique mechanisms of action. EPO is a primary endurance booster believed to improve performance by increasing the oxygen available in the blood for muscles. DNP, on the other hand, is an ingredient found in non-nutritive products such as TNT and pesticides. Taking this substance usually results in increased body temperature and is thought to reduce body fat through over-production of heat. 4 Prohormones and Nutritional Supplements. APED users will often add other legal substances to their cycles which can be purchased over the internet or through nutritional supplement stores. The most common of these substances include protein supplements and creatine, but these substances can target a wide range of potential biological mechanisms associated with muscle gain, performance enhancement, or fat reduction (see ergo/thermogenics above). Prohormones are a particularly relevant supplement as they are typically pre-cursor hormones that break down into testosterone through natural processes once injected. In some instances, individuals will inject these substances to maximize their effects as the prohormones often lose their potency when digested naturally through the stomach. APED Phenomenology: The use of APEDs has a range of associated behavioral and psychological features. Most notably, APEDs are used in the context of some form of exercise, performance, or competition. These contexts may direct the pattern of APED use as different disciplines are likely associated with APED patterns designed to maximize success or goal achievement. This may be obvious for certain types of competition such as powerlifting, where strength and size are valued over characteristics such as muscle definition or endurance. Exercise, in some form, will likely occur with all APED users. The nature of this exercise will vary widely based on idiosyncratic differences in goals, experience, and knowledge, but several features of APED users’ exercise regimen assessed in the APEDUS. Specifically, the APEDUS targets the degree to which exercise is aerobic or anerobic, the amount of time spent in these respective forms of exercise, and the degree to which exercise is a pleasure seeking process or an affect neutralizing process. A similar common phenomenological experience shared by most APED users is dietary control. Many APED users will attempt to control macro and micro nutrient content in efforts to maximize their appearance or performance related goals. As with exercise, these forms of control are idiosyncratic and likely influenced by the context in which APEDs are used. For example, bodybuilders will consume varying amounts of protein, fat, and carbohydrates depending on where they are in their training plan with typical patterns including acute starvation precompetition to bring out vascularity (visible evidence of veins surrounding the muscle) or volume associated with subcutaneous fat. The APEDUS contains items assessing several aspects of dietary control, including the level of investment in a specific dietary plan, adherence to that plan, and psychological effects of deviating from that plan. As with exercise, the dietary items also assess the relative function of this dietary control as either producing pleasure or attempt to neutralize affect. Appearance is also an integral part of APED phenomenology. In most cases, the use of these drugs will target specific changes in appearance such as increased muscle mass, increased leanness or “vascularity”, or the combination of these dimensions. The items of the APEDUS measure the importance of appearance and the degree to which certain individuals engage in behaviors or think about appearance that reflects affect neutralization, along with the degree to which the individual engages in behaviors or thinking that indicates that the body or appearance is a source of pleasure, novelty, or reward. In particular, the items are designed to scale the pathological forms of these constructs. APED use may take on a rather wide range of drug use, exercise, and dietary patterns, but also has considerable variation in the degree of social regulation of these behaviors and attitudes. For these reasons, there are specific items within the APEDUS to target the degree to which APED use exists as part of a larger social context. For instance, APED users are 5 likely to gain advice on a wide range of behavior from individuals perceived to have expertise in the use of APEDs. In addition, they may use internet discussion boards and postings to exchange information about use patterns, diets, exercise regimens, etc. Finally, there are a number of potential risks, physical, psychological, social, and legal, that is associated with APED use. Many APEDs are illegal and there may be significant risks involved with the purchase and possession of these substances. Furthermore, some APED users will take other risks, experimenting with high doses or dangerous patterns of use, or using homemade APEDs where the quality and safety of the drugs may be questionable. This risk taking pattern as well as the investment of men/women in taking these substances is believed to influence future APED use. Using the APEDUS The APEDUS is separated into eight modules designed to canvas the most common phenomena of APEDUS use. These modules may be used separately or in any combination depending upon the particular research questions being asked. In its full form, the interview should average approximately 1 hr. The APEDUS also includes a common introduction that we recommend to be used with any combination of the modules. The structure of the APEDUS is as follows: 1. Background & Demographics 2. Module I: Training History and Identity 3. Module II: Dietary History and Practices 4. Module III:Body Image and Appearance Control 5. Module IV: Nutritional Supplements and Prohormone Use 6. Module V: First Appearance and Performance Enhancing Drug Cycle 7. Module VI: Current/Most Recent Appearance and Performance Enhancing Drug Cycle 8. Module VII:Usual Appearance and Performance Enhancing Drug Cycle 9. Module VIII:Social Context of Appearance and Performance Enhancing Drug Use 10. Module IX: Risk and Future Use The APEDUS uses a couple of common interview techniques that the interviewer should familiarize him/herself with before conducting an interview. First, the APEDUS is a semi-structured interview so all ratings are made by the clinician taking into account the information provided in response to the question. If an interviewee reports inconsistent responses across similar items, then it is up to the interviewer to resolve the inconsistency with further questioning of the interviewee. If necessary, the interviewer may go back to earlier parts of the interview to resolve discrepancies. Second, the interviewer should keep the interviewee on track, redirecting him/her when digressions to the questions occur while maintaining rapport. Third, many of the questions refer to the last 28 days or month. This design feature allows to the interviewer to capture the most recent APED phenomena. All items that lead with “…” should be read with the beginning statement, “Over the past 28 days…”. When collecting information on this time period, code the rating that reflects only this time period. If the interviewee had difficulty making ratings for this time period, ask him/her to list some of the activities he/she engaged in over the past month and have him/her use these anchors to help 6 approximate to the answer. If the interviewee still has trouble with the time frame, have them make the best approximation using the scale provided. When an item is not applicable or impossible to rate based on the interviewers response or experience, code “-9”. For several of the sections, the interviewee will be asked to describe a pattern of drug use or side effects related to that side effect. To increase the efficiency of this process, we have included the use of drug/side effects lists to be used with the interview. When using these lists, make sure to hand the list to the interviewee when arriving at the appropriate section. Have the interviewee list all the substances he or she used for the referent time period and use the appropriate follow-up questions when necessary. It is possible that the list of drugs provided does not include a specific substance used by the interviewee. In this case, have the interviewee provide as much information as possible on the substance (e.g., street name, true drug name, and typical metric for dosing. For coding purposes, all codes should be recorded in the grey tinted boxes. For Likert-type scales, which will have the appropriate item tag to the lower right of the box, circle the most appropriate number. The codes in the lower right corner are for data entry purposes and are used to identify the appropriate cell in the corresponding spreadsheet. 7 BACKGROUND AND DEMOGRAPHICS Basic Demographics 1. What is your sex? male: 0 female: 1 1 2. What is your Age? # of years 2 # inches 3 # lbs 4 % body fat 5 3. Height 4. Weight 5. Body Fat Percentage Code “-9” if unknown Race and Ethnicity 6. How would you define your racial background? White, Caucasian, or European American Black or African American American Indian or Alaskan Native Asian Native Hawaiian or Other Pacific Islander 0 1 2 3 4 Hispanic or Latino Not Hispanic or Latino 0 1 7. How would you define your ethnic background? Notes: 6 7 Occupational and Living Status 8. What is your Marital Status? Never Married Widowed Divorced Separated Living as Married Married 0 1 2 3 4 5 8 8 9. What is your Sexual Orientation? 10. What is your employment status? 11. What is your Occupation? Primarily Heterosexual Bisexual Primarily Homosexual 0 1 2 9 Employed full-time Employed part-time Homemaker Student full-time Retired Unemployed Disabled 0 1 2 3 4 5 6 10 Notes. 11 12. What is your approximate annual household income? $ 12 13. What is the highest level of education you’ve received? Calculate the total number of years based on interviewee’s response. # years 14. Have you ever served in the military or armed forces? 15. Did you see any combat in the military? 16. Were you injured in combat? 13 No 0 Yes 1 14 N/A -9 No 0 Yes 1 15 N/A -9 No 0 Yes 1 16 17. How long did you serve in the military? years 9 17 Medical History and Status 18. Have you ever been hospitalized for an injury related to your exercise, training, or athletic competition? No Yes 0 1 # of times 19. How many times? 20. Have you ever been knocked unconscious or received some other sort of injury to your head? (N/A = -9) No Yes 0 1 21. How many times? 19 23. Have you ever been diagnosed with high cholesterol? 24. Has either of your biological parents ever been diagnosed with a heart problem or high cholesterol? Code “-9” if unknown. 25. Have you ever been hospitalized for psychiatric or psychological reasons? 21 No Yes 0 1 22 No 0 Yes 1 23 N/A No Yes -9 0 1 No Yes 0 1 26. How many times? 25 # of times (N/A = -9) 27. Are you currently receiving psychological/psychiatric treatment of any type? 20 # of times (N/A = -9) 22. Have you ever been diagnosed with a heart condition? 18 No Yes 0 1 26 27 10 24 28. What type of treatment? Notes. 28 29-32. What medications are you currently taking for a medical or psychological/ psychiatric reason that are not related to your APED use? Nam e Get the list as best the interviewee can recall. For the fourth column code “0” if the interviewee is taking the medication without the supervision of a medical professional and “1” if the medication was obtained through a prescription of a medical professional. Reason Dose Prescription 29a 30a 31a 32a 29b 30b 31b 32b 29c 30c 31c 32c Notes. 11 TRAINING HISTORY AND IDENTITY I am now going to ask you some specific questions about your exercise, athletic, and training practices, what they mean to you, and how they may have changed over time. 1. At what age did you first begin regular exercise? yrs 1 a)**Was this exercise something you did almost every day? If no… when did you first exercise more days than not for at least six months? b)**How long did you keep it up… was it at least 6 months? If no… when was the first time you exercised this way for at least six months? Exercise must have been regular and occurred for more than a six month period with exercise occurring more days than not over that period. Examples include weight training, aerobics, and team sports. 2. In the past month, what has been your primary method of exercise or training? Be specific to the past month. If there is variation, rate the method that accounted for the majority of time over the past four weeks. **What percentage of the time did you spend on cardio or endurance exercise? **What about power, strength, or mass building exercises?... Which do you rely on more? Exclusively cardio/endurance (e.g., marathon, distance cycling, etc.) Primarily cardio /endurance (e.g., aerobics, dance, competitive fitness, swimming, etc.) Notable reliance on cardio/ endurance (e.g., soccer, intermediate racing, etc.) Equivalent reliance on cardio/endurance and power, size, strength (e.g., boxing, mountain climbing, etc.) Notable reliance on strength, power, size (e.g., football, sprinter, decathlon, etc.) 0 1 2 3 4 Exercise where success or achievement is primarily related to cardiovascular fitness or muscular endurance Exercise where success or achievement depends on cardiovascular fitness/muscular endurance and physical strength, power, or size. Primarily strength, power, or size (e.g., wrestling, combat sports, etc.) Exclusively strength, power, or size (e.g., power lifting, strong man competition, etc.) 5 6 Exercise where success or achievement is primarily related to power, size, or endurance 12 2 3. In the past month, how many days have you exercised? 4. On the days that you have exercised, how much time did you spend exercising? 5. What has been the longest continuous period of time you spent exercising at one time over the past month? # days 3 # hours 4 # min 5 THE REMAINING QUESTIONS WILL REFER TO THIS SPECIFIC TIME PERIOD OF EXERCISE/TRAINING. EACH QUESTION SHOULD BEGIN “Over the past month…” 6. …did you ever feel like exercise was something you had to do? If No… skip to “b” a)**How often did you feel this way?... Did it occur every day? b)**What about feeling like a burden?... How often did you feel this way? If No… code “0” To be rated above a “0” there must be some evidence that the interviewee experienced exercise as a burden or driven by the avoidance of some degree of negative affect. 0-4 0 5-8 1 9-12 2 13-16 3 17-20 4 21-23 5 24-28 6 13 6 7. …did you exercise because you were feeling bad [anxious, depressed, etc.]? Could you give an example? a)**Did you use exercise to control these feelings? b)**What percentage of the [___days from item #3] did you use exercise for this purpose? The use of “neutralizing” exercise should be differentiated from “pleasure seeking” exercise. The goal of neutralizing exercise is to feel “normal” or to reduce anxiety or worry as opposed to a goal of feeling “better than normal.” Interviewees can have both of these goals over the course of a month, but we want to scale the percentage of time it was present. Calculate based on #days exercised. For example, an answer of 3 out of 12 days exercised =25% or code “2”. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 7 8. …have you had to make an unwanted change to your exercise routine? If Yes…a)**How badly did you feel when this happened?... How long did the feeling last? If No…b)**How badly would you have felt if you had to change your routine or couldn’t complete all the training you had planned? There must be notable distress or anxiety expressed by the interviewee to code above a “0”. None Very Little Some Moderate Significant A Great Deal Extreme 0 1 2 3 4 5 6 Absence or very little distress. When distress occurs, it has no measurable impact on daily life. Clear distress with observable duration and some measurable impact on daily life. For example, more irritable around co-workers or with loved ones. Distress never resolved, only resolved with compensation, or results in functional impairment. 14 8 9. …have you found yourself being preoccupied with exercise or thought about exercise even when you did not want to? a)**How often does this occur?...How long does it last when it happens? b)**How much does it bother you or interfere with things you are actively trying to do… for example, concentrating at work or carrying on a conversation? Preoccupation must be experienced as intrusive, unwanted or clearly dysfunctional thoughts about exercise and it must occur in contexts where it is not desirable or functional. For instance, when carrying on a conversation with a friend, while concentrating on work or school, or when trying to relax. Preoccupation does not include purposeful thought about exercise. No impairment 0 No preoccupation Very Little Impairment Some Impairment Moderate Impairment Significant Impairment A Great Deal of Impairment 1 2 3 4 5 Occurs infrequently or it has little Occurs frequently or when it appreciable impact on his/her life occurs it has a strong impact on his/her life Extreme Impairment 6 Frequent and Impairing 9 10. …did you fear that your athletic ability or looks would deteriorate if you didn’t keep up your exercise schedule or intensity? If No… Would you be anxious if you were unable to keep up with your current exercise level? If yes… how intense was that fear?...Did this fear interfere with your life at all? This question is specific to the fear or anxiety that motivates exercise. For example, someone may do1 hr of sit-ups or crunches per day to prevent the loss of “six pack abs”. If there is no acknowledgement of fear, but interviewee attributes this to successful prevention of fear through exercise code greater than 0. None 0 No Fear Very Little Some Moderate Significant A Great Deal 1 2 3 4 5 Evidence of fear that either occurs infrequently, is mild in intensity, or has little impact on life Evidence of fear that occurs frequently, is intense, or has strong impact on life Extreme 6 Frequent, intense, & impairing 15 10 11. …did you ever become uncomfortable or upset because an exercise, lift, or athletic drill didn’t feel right? a)**…did you have to repeat an exercise, drill, or lift because it didn’t feel right? b)**How often did this occur over the past month?... that is, what percentage of your exercise or training did you have to execute until it fell right? This question measures the compulsive need for exercise or athletic activity to lead to affect neutralization. This must be evidence that the executing a given exercise, lift, or athletic drill will neutralize or reduce some internal negative feeling. This may be related to an extreme sense of perfectionism or superstitious belief about quality of exercise. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 11 12. …did you experience a “high” or feeling of intense pleasure while exercising?... could you give an example? If No… code “0” for items 12—15. If yes… a) Did it occur during the actual exercise or shortly after? b) What percentage of [___#days item 3] that you exercised did you feel this way? This item scales the experience of pleasure during the actual exercise. This feeling should be differentiated from positive anticipation pre-exercise. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 16 12 13. …[only ask if coded > 0 on item 12] thinking back to the times you felt this way… could you describe how intense the feeling was? **Was it intense enough that it blocked the feeling of pain or fatigue? This item scales the intensity of the pleasure during the actual exercise. Again, differentiate this from pre-exercise anticipation. None at all 0 Very little A little Somewhat A lot Very Much 1 2 3 4 5 A noticeable change from preIntensity of pleasure obscures exercise, but able to experience other emotions or sensations other emotions or sensations (e.g., (e.g., pain, fatigue, etc.) pain, fatigue, etc.) Extreme 6 Could not feel other emotions or sensations 13 14. …[only ask if coded > 0 on item 12] did these “highs” lead to exercising longer than intended? Could you give an example? If yes… a) What percentage of the [___#days from item 3] that you exercised did this occur? Distinguish this from simple over exercise in that it must have been pleasure driven and lead to exercise that was unplanned or undesired. For example, planning on running for 2 miles, but running 5 miles because it felt good. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 17 14 15. …have you increased the intensity or duration of your exercise? If Yes… a)**Has this increase been to achieve a “high” or intense pleasure that you no longer experienced? b) How much have you had to increase the intensity or duration of your exercise to get the same effects? This question is designed to address the degree of tolerance to exercise effects that have developed of the past 4 weeks. Do not consider planned increases in exercise intensity or duration in relation to specific training plan or goal. The exercise must functionally produce some recognizable pleasure or positive feeling to be rated above a zero. None at all 0 No change Very little A little Somewhat A lot Very Much 1 2 3 4 5 Either time or intensity of Time and/or intensity increases exercise increases, but only on a on most days or changes reflect few days or slight amount a distinct increase (e.g., twice as much time to achieve same high) Extreme 6 Same feeling never attained despite significant changes 18 15 DIETARY HISTORY AND PRACTICES I’m now going to ask you some specific questions about your diet or the food that you eat and how you make decisions about your diet. Start each relevant question with “Over the past month…” 1. At what age did you first begin watching the amount, type, or frequency of food you ate? Dietary control must have been regular and occurred for more than a six month period with regulation or control occurring more days than not over that period. This regulation or control may vary from restriction of calories to frequent attempts to overeat to gain weight. Structured plans for eating will also qualify as long as the methods were intentional. yrs 1 2. Could you describe this first attempt to change your eating? Get a general picture of the types of rules/ guidelines used. Follow up with the following questions **Was caloric intake important to you?...were you trying to lose or gain weight? If yes continue to item below. If no code “-9” **How much did calories influence decisions you made about food? Consider the interviewee’s perception of the number of calories necessary to maintain energy balance for activity level, age, and gender. A “3” represents complete energy balance. N/A -9 Extreme restriction of calories. (includes periods of fasting or eating non-caloric food) Substantial caloric restriction. (caloric intake is clearly below that needed to achieve energy balance). 0 1 Successful control requires the intake of no calories or only enough for minimal functioning. Mild caloric restriction. (Likely a negative energy imbalance, but not severe) Energy Balance (no consistent restriction or overeating) Mild caloric overconsumption (Likely a positive energy imbalance, but not severe) 2 3 4 Successful control requires caloric regulation that approximates energy balance. Substantial caloric overconsumption (Clear positive energy imbalance) Extreme overconsumption (intentional and persistent overeating) 5 6 Successful control requires overconsumption of calories 19 2 3**What about macronutrients… that is, did you base your diet upon the amount of protein, carbohydrates, or fats? If yes continue to item below otherwise code -9. **Were there other important aspects of nutrition that influenced the food you ate?... Please describe? **How much did macronutrient content influence the decisions you made about food? The degree to which one’s eating pattern favored specific macronutrient content. For example a high protein low fat diet (regardless of calorie consumption) would be scored higher than “0” because of use of macronutrients to inform dietary decisions. N/A -9 No influence of macro-nutrient content on caloric consumption Little influence of macronutrient content on caloric consumption. 0 1 Caloric control independent of macronutrient content. Some macronutrient control but other aspects more important. Equivalent reliance on macro-nutrient control vs. other methods of control. Notable macronutrient control 2 3 4 Caloric control depends upon macronutrient content, but other aspects or nutrition or regulation has considerable influence over daily caloric consumption. Primarily macronutrient control. Exclusively macro-nutrient control. 5 6 Caloric control heavily related to macronutrient content. 20 3 WE’RE NOW GOING TO FOCUS ON YOUR DIETARY PRACTICES OVER THE PAST MONTH 4. In the past month, were you attempting control your diet? Please explain. Get a general picture of the types of rules or guidelines used over the past 4 weeks. Follow up with the following questions: If no… code “-9” **Did you watch the number of calories you consumed? If yes continue below. If no, code “-9” and move to next item. **Did calories influence your decisions about food? Consider the interviewee’s perception of the number of calories necessary to maintain energy balance for activity level, age, and gender. A “3” represents complete energy balance. N/A -9 Extreme restriction of calories. (includes periods of fasting or consumption of non-caloric food) Substantial Caloric restriction. (Caloric intake is clearly below that needed to achieve energy balance). 0 1 Successful control requires the intake of no calories or only enough for minimal functioning. Mild caloric restriction. (Likely a negative energy imbalance, but not severe) Energy Balance (no consistent restriction or overeating) Mild caloric overconsumption (Likely a positive energy imbalance, but not severe) 2 3 4 Successful control requires caloric regulation that approximates energy balance. Substantial caloric overconsumption (Clear positive energy imbalance) Extreme overconsumption (intentional and persistent overeating) 5 6 Successful control requires overconsumption of calories 4 5. …how about macronutrients… did you keep track of them? *Did macronutrients influence your decisions about food? N/A -9 No influence of macro-nutrient content on caloric consumption Little influence of macronutrient content on caloric consumption. 0 1 Caloric control independent of macronutrient content. Some macronutrient control but other aspects more important. Equivalent reliance on macro-nutrient control vs. other methods of control. Notable macronutrient control 2 3 4 Caloric control depends upon macronutrient content, but other aspects or nutrition or regulation has considerable influence over daily caloric consumption. Primarily macro-nutrient control. Exclusively macro-nutrient control. 5 6 Caloric control heavily related to macronutrient content. 21 5 # days 6. …how many days have you trying to control your diet? 6 7. …how successful have you been at controlling your diet? Rate interviewee’s perception of success. Code “-9” if no attempt at regulation. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 1 2 3 4 5 6 7 8. …did you feel controlling your diet was something you had to do? If No… skip to “b” a)**How often did you feel this way?... Did it occur every day? b)**What about feeling like a burden?...How often did you feel this way? To be rated above a “0” there must be some evidence that the interviewee experienced caloric or macronutrient control as a burden or driven by the avoidance of some degree of negative emotion. If no evidence of attempt at dietary control, then code “-9”. N/A -9 0-4 0 5-8 1 9-12 2 13-16 3 17-20 4 21-23 5 24-28 6 22 8 9. …did you feel bad about the way you looked, your physical health, or your athletic ability? If No… Ask “a” *Did controlling your diet reduce these feelings?...What percentage of the time? a) Did success with your diet prevent you from feeling bad? (Code 6 if “yes”) The use of “neutralizing/prevention” should be differentiated from “pleasure seeking” eating. The goal of neutralizing or compensatory caloric/macronutrient control is to feel “normal” or to reduce anxiety or worry as opposed to a goal of feeling “better than normal.” Interviewees can have both of these goals over the course of a month, but this item scales the percentage of time dietary control was used compulsively. Code “-9” if there is no evidence of regulated eating. N/A Never Seldom Occasionally About Half Time Sometimes Frequently Always -9 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 9 10. …did you deviate from your diet at all? If No, skip to “c” If yes…a)**Did you feel bad when this happened? Please describe. b) How intense was this feeling? …How long did it last? c)**How would you have felt if you deviated from your diet? Please describe. If no attempts at regulating eating than code “-9”. N/A None at all -9 0 No reaction Very little A little Somewhat A lot Very Much Extreme 1 2 3 4 5 6 Some emotional disturbance. Clear distress associated with Can’t Low intensity or feeling fades deviation. High intensity or tolerate quickly persistence of emotion. associated distress 23 10 11. …have you found yourself being preoccupied with food, eating, or nutrition or thought about food, eating, or nutrition even when you did not want to? a)**How often does this occur? b)**How much does it bother you or interfere with things you are actively trying to do… for example, concentrating at work or carrying on a conversation. Preoccupation must be experienced as intrusive or unwanted thoughts about food, eating, or calories and it must occur in contexts where it is not desirable or functional. For instance, when carrying on a conversation with a friend, while concentrating on work or school, or when trying to relax. Preoccupation does not include purposeful thought about food, eating, or calories. N/A Never Seldom Occasionally -9 0 1 2 No preOccurs infrequently or it has little occupation appreciable impact on his/her life About Half Time Sometimes Usually 3 4 5 Occurs frequently or when it occurs it has a strong impact on his/her life Always 6 Frequent and Impairing 11 12. …were you concerned that your looks, your health, or your athletic ability would deteriorate if you didn’t control your diet? **Did sticking to your diet reduce these concerns? What percentage of the time? This item measures the amount of time which dieting decisions function as harm avoidance or prevention of undesirable changes in appearance, health status, or athletic ability. When determining the percentage keep in mind that most interviewees will be eating 3-5 times per day over a 28 day period. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 24 12 13. …did dietary control lead to a “dieting high” or feeling of intense pleasure? **Was this in response to caloric restriction? On how many days did you experience this feeling? This item scales the experience of pleasure from sticking to or regulating nutritional content or achieving nutritional goals. This feeling should be differentiated from the feeling of accomplishment, success, or dominance. It will typically be in response to severe restriction. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0-4 days 1 5-8 days 2 9-12 days 3 13-16 days 4 17-20 days 5 21-24 days 6 25-28 days 13 14. …did you experience a strong desire or craving for a specific food or type of foods?... Please give an example. What about foods you were trying to restrict or cut out of your diet (e.g., chocolate bars, French fries, etc.)? Did you avoid cravings by eating the foods that you wanted? **On how many days did you experience these cravings or end up eating certain foods to avoid these cravings? In this context strong desire and craving are experienced as positive anticipation of the actual effects of eating that food. For interviewees who could not tolerate being unable to eat certain foods when they desire to eat them code a “6”. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0-4 days 1 5-8 days 2 9-12 days 3 13-16 days 4 17-20 days 5 21-24 days 6 25-28 days 25 14 15. …did the positive experiences related to food (e.g., taste, etc.) lead to consuming more than intended? **On how many days did this happen? Distinguish this from simple overeating in that it must have been pleasure driven and must have lead to eating that was unplanned or undesired. For example, planning on having one cookie, but eating 5 because it felt/tasted good. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0-4 days 1 5-8 days 2 9-12 days 3 13-16 days 4 17-20 days 5 21-24 days 6 25-28 days 15 16. …did you end up losing control over your eating? (If No, code “0” for items 16 & 17) Could you give an example? Were you intending to eat something different or eat less? How did you feel when you were actually eating? Was this part of a “cheat day”? Loss of control is present when control or regulation was attempted or intended, but not executed. Loss of control is distinguished from simple regret or guilt about eating, which may occur during loss of control but are not necessary for the experience of loss of control. For example, some people may plan “cheat days” to manage the experience of loss of control without regret or guilt. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0-4 days 1 5-8 days 2 9-12 days 3 13-16 days 4 17-20 days 5 21-24 days 6 25-28 days 26 16 17. … did you attempt to compensate for these times you lost of control? For example, did you cut back on quantity, type, or amount of food? **Did you get stricter with your diet or increase the intensity of your workouts to eliminate the effects of losing control? Please describe. **On how many days did you try to compensate? A common form of compensation will be increasing restriction (calories or macronutrient content) to compensate for overeating or breaking a dietary rule. Code “-9” if there was no attempt to regulate eating. N/A Never Seldom Occasionally About Half Time Sometimes Usually Always -9 0 0-4 days 1 5-8 days 2 9-12 days 3 13-16 days 4 17-20 days 5 21-24 days 6 25-28 days 17 18. …in general, how successful have your efforts been at controlling your diet? This item refers to global attitudes or beliefs about the efficacy of the interviewees’ attempts at dietary control. Consider the interviewee’s perception of success, not actual success. Code “-9” if the interviewee has had no attempt to regulate eating. N/A Very Unsuccessful Somewhat unsuccessful A little unsuccessful Neither successful or unsuccessful A little successful Somewhat successful Very Successful -9 0 1 2 3 4 5 6 27 18 19. …How important was your diet… That is how much did eating or its effects matter to you? **Was it more important than exercise or athletic performance? **Was it more important than other areas of your life such as work, school, or relationships? Diet includes anything related to the consumption of food or other products designed to provide nutrition (e.g., calories, macronutrients, micronutrients, etc.). Not of much importance N/A No importance. -9 0 1 Little to no recognition that outward appearance matters Recognized importance, but not as important as other areas. Moderate Importance. Other areas of equal importance Clearly a priority, but recognizes the importance of other areas 2 3 4 Recognized or observable evidence that outward appearance matters Primary importance The most important aspect of life 5 6 Outward appearance is of primarily importance 28 19 BODY IMAGE AND APPEARANCE CONTROL I’m now going to ask you some questions about the way you think about and evaluate your appearance. 1. …how important was it that your body looked a certain way… that is how much did your outward appearance matter to you? **Was it more important than exercise or athletic performance? **Was it more important than other areas of your life such as work, school, or relationships? The importance in appearance can be inter or intrapersonal. This investment should be separated from functional aspects of the body (e.g., strength, dexterity, etc.). No Importance Negligible Importance 0 1 Little to no recognition that outward appearance matters Some Importance Important Significant Importance 2 3 4 Recognized or observable evidence that outward appearance matters Primary Importance Total Importance 5 6 Outward appearance is of primarily importance 1 2. …how important was exercising… That is, how much did your athletic ability matter to you? How about in comparison to other areas of your life such as relationships, job performance, or your health? The importance of performance is distinct from appearance although an interviewee may be invested in both. No Importance Negligible Importance 0 1 Little to no recognition that function or performance matters. Some Importance Important Significant Importance 2 3 4 Recognized or observable evidence that function or performance matters. Primary Importance Total Importance 5 6 Function or performance is of primary importance 29 2 3. …Did you scrutinize or evaluate the way you look or your athletic performance? What specifically did you evaluate? How did you go about you doing this? How often did you find yourself doing this? …did it happen every day? Get a general picture of the types of evaluation methods used (e.g., weighing, body fat testing, body checking). Give examples if the interviewee is unclear or denies evaluation. Evaluation assumes some sort of standard or comparison which may range from direct comparison to others or internal comparison to personal standard. Never Seldom 0 1 No observable attempts to evaluate appearance or performance Occasionally About Half Time Sometimes 2 3 4 Recognized or observed attempts to evaluate appearance or performance. Occurs > 1/week. Frequently Always 5 6 Evaluation takes up a marked period of time on a daily basis. 3 4. …were you unsure about the way you looked or your athletic ability? Critical or negative evaluations should be internal and not originate from a coach, friend, or partner. *…did this bother you?... did you find yourself evaluating your appearance or athletic ability because of this uncertainty? *How often did this happen? The item measures the degree to which body checking or scrutiny is used to resolve the discomfort over uncertainty about appearance. Never Seldom 0 1 No observable attempts to evaluate appearance or performance Occasionally About Half Time Sometimes 2 3 4 Recognized or observed attempts to reduce uncertainty with checking or scrutiny. Occurs > 1/week. Frequently Always 5 6 Checking or scrutiny takes up a marked period of time on a daily basis. 30 4 5. … did evaluation of your looks or athletic ability lead to positive thoughts or feelings of confidence? Please give an example. **What percentage of the times that you evaluated yourself did it lead to feeling good? As with the above question, evaluations should be internal and lead to noticeable feelings of wellbeing. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 0% 1 1-20% 2 21-40% 3 41-60% 4 61%-80% 5 81%-99% 6 100% 5 6. …did you seek positive feedback about your looks or athletic ability from other people? For example, ask your partner to comment on your muscle definition or strength. How often did this occur? Was it every day?... More than 1 x per day? Reassurance in this context is actively pursued and not spontaneously given and may constitute a wide range of aspects of appearance or performance (e.g. form while lifting weights, presence of visible musculature, execution of a play or something objective such as scale weight). Never Seldom Occasionally About Half Time Sometimes Frequently 0 1 2 3 4 5 No days As much as a couple of times per week At least 2-3 times per week More days than not and/or multiple times per day Always 6 Every day 31 6 7. …[If Item 6 = 0, skip to Item 8 and code “0”] did feedback from others, positive or negative, to reduce doubts or uncertainty about the way you look or your athletic ability? For example, sometimes people ask others to evaluate their form while executing a certain lift, or will inquire about the symmetry of their muscles to determine where to focus. **How often did this occur? Did it happen every day?… More than 1 x per day? Reassurance in this context is actively pursued and not spontaneously given and may constitute a wide range of aspects of appearance or performance (e.g. form while lifting weights, presence of visible musculature, execution of a play or something objective such as scale weight. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 1 2 3 4 5 6 No days As much as a couple of times per week At least 2-3 times per week More days than not and/or multiple times per day 7 Every day 8. …did you avoid looking at or evaluating different aspects of your body? If No… Did you experience discomfort when certain aspects of your body were exposed? How much did this bother you? Did this avoidance or discomfort interfere with your life over the past month? Did you do anything to avoid seeing yourself or to avoid self evaluation or evaluation by others? Body avoidance may consist of ignoring reflective surfaces, refusing to look at pictures of oneself, avoiding the scale, etc. Avoidance may also be identified by the level of discomfort present when exposure is forced or happens by circumstance (e.g., someone brings a picture to a party, etc.). No Impairment 0 Very Little Impairment A little Impairment 1 2 Avoidance or distress occurs but has little impact on daily activities Some Impairment 3 Some impact, but functioning in several domains A lot of Impairment Very Much Impairment 4 5 Affects multiple domains and occurs almost daily Extreme Impairment 6 Affects most aspects of life on daily basis 32 8 9. … have you been preoccupied with the way you look? **Did you find yourself thinking about the way you look even when you didn’t want to? **How often did it occur? Was it every day? **When it did occur, how long did it last? **How much does it bother you or interfere with things you are actively trying to do… for example, concentrating at work or carrying on a conversation. Preoccupation must be experienced as intrusive or unwanted thoughts about appearance or performance and it must occur in contexts where it is not desirable or functional. For instance, when carrying on a conversation with a friend, while concentrating on work or school, or when trying to relax. Preoccupation does not include purposeful thought about bodily appearance or physical performance. No Impairment 0 Very Little Impairment A little Impairment 1 2 Preoccupation occurs but has little impact on daily activities Some Impairment 3 Some impact, but functioning in several domains A lot of Impairment Very Much Impairment 4 5 Preoccupation affects multiple domains and occurs almost daily Extreme Impairment 6 Affects most aspects of life on a daily basis 9 10. …did you find yourself looking in the mirror because it felt good? **Did you have difficulty stopping because it felt so good? Please describe. **On how many days did this happen? This question taps the experience of pleasure derived from one’s appearance and the experience of pleasure leading to excess, unwanted, or uncontrolled behavior. Never Seldom Occasionally 0 0-4 days 1 5-8 days 2 9-12 days About Half Time Sometimes Frequently Always 3 4 5 6 13-16 days 17-20 days 21-24 days 25-28 days 33 10 11. …How often did you impulsively buy clothing, grooming supplies, or workout gear to enhance your appearance or improve performance? Impulse requires a lack of consideration for the negative consequences such as costs, ineffectiveness of the product, or lack of support for workout device. For example, someone who describes the inability to resist purchasing the newest ab contraption. Never Seldom Occasionally About Half Time Sometimes Frequently Always 0 1 1-2 times/mo 2 3-5 times/mo 3 5-10 times/mo 4 11-14 times/mo 5 15-20 times/mo 6 >20 times/mo 34 11 NUTRITIONAL SUPPLEMENTS AND PROHORMONES “Give me a general sense of what kinds of supplements or you have used… the ones you can buy over-the-counter” “Have you ever used a nutritional supplement such as protein powder, vitamins, or amino acids?” “Have you ever used prohormones such as androstenedione, androstenediol, norandrostenedione, norandrostenediol, DHEA, HMB?” “Have you ever used an over-the-counter fat burner or diet pill… how about a supplement in increase your energy or endurance?” What did you use _____ for? (Get a general sense of what the supplements/prohormones were used for) If used a Nutritional Supplement other than an OTC ergo/thermogenic.… complete items 1-11 If used a Prohormone… complete items 12-21 If used a OTC ergo/thermogenic complete items 22-33 ** If No to all check box and SKIP TO “Module D” 35 1. At what age did you first take a nutritional supplement other than a prohormone or over-the-counter fat burner/endurance booster? years Who was your primary influence, if anyone, to begin using nutritional supplements? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to use a nutritional supplement. 2. Coach or athletic trainer 3. Physician or medical personnel. 4. Teammate or other athlete 5. Friend or family member 6. Scout or agent 7. Advertisements 8. Celebrity (famous athlete or coach) 9. Internet advice 10. Independent or self directed? 11. Do you currently use nutritional supplements? No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 1 2 3 4 5 6 7 8 9 10 11 36 12. At what age did you first take a prohormone? Code “-9” if never taken a prohormone. years Who was your primary influence, if anyone, to begin using prohormones? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to use a prohormone. 13. Coach or athletic trainer 14. Physician or medical personnel. 15. Teammate or other athlete 16. Friend or family member 17. Scout or agent 18. Advertisements 19. Celebrity (famous athlete or coach) 20. Internet advice 21. Independent or self-directed 22. Do you currently use prohormones? No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 12 13 14 15 16 17 18 19 20 21 22 37 23. At what age did you first take an Over-the Counter fat burner or endurance booster? Code “-9” if never taken an OTC ergo/thermogenic. years Who was your primary influence, if anyone, to begin using over-the-counter fat burner/endurance boosters? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to use an OTC ergo/thermogenic . 24. Coach or athletic trainer 25. Physician or medical personnel. 26. Teammate or other athlete 27. Friend or family member 28. Scout or agent 29. Advertisements 30. Celebrity (famous athlete or coach) 31. Internet advice 32. Independent or self-directed 33. Do you currently use an over-the-counter fat burner/endurance booster? No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 23 24 25 26 27 28 29 30 31 32 33 38 GENERAL INTRODUCTION TO APED MODULES I would first like to get a general sense of your experience with using substances to improve your appearance or alter your performance… Have you ever used hormones such as testosterone or any other anabolic steroids? In what pattern(s) do you these drugs? ***Do you “cycle” these drugs… if unaware of the terminology, then describe: “A prescribed period of time in which you take steroids, other hormones, or supplements or increase the amount of these drugs taken. This period is followed by a period of discontinuation, where you let your body recover from the drug use. ***Do you bridge between cycles?... if unaware of the terminology, then describe: “A low dose of testosterone or similar substance to maintain steroid effects between cycles. If the low dose is just used constantly, it is sometimes referred to as hormone replacement.” N/A No -9 0 Yes 1 1 In the following set of questions, I will refer to these substances as “APEDs” and the pattern as an “APED cycle.” The term “cycle” includes the increase of APEDs while on a steady low dose of testosterone or derivative). I will ask you about your experiences while “on-cycle” as well as the period of discontinuation (or APED reduction), which I will label “post-cycle”. How many cycles have you completed in your life? (If less than 3, do not complete “Usual use Module) Cycles 2 Has your pattern of APED use changed over time? Are your cycles different than when you first started using? (If no, skip “Usual use Module”). ….If so, how much has the types and dosages of drugs and duration of your cycles changed since your first cycle? (If the drugs, dosages, duration are similar to first and last than skip “Usual use Module”). 39 We’re going to start by focusing on this first time you took APEDs. [Only if starting with first APED Use] We’re going to focus on your most recent or current use of APEDs [Only if starting with most recent or current APED use] We’re going to focus on the ways you typically use APEDs [Only if starting with usual APED Use] 40 FIRST APPEARANCE AND PERFORMANCE ENHANCING DRUG CYCLE Think back to the first time you ever took an appearance and performance enhancing substance. Do not include creatine, protein supplements, or similar nutritive products. The APED cycle we are targeting must have included, at some point, an illegal anabolic agent and/or an illegal fat-burner or endurance booster. …the following questions will be specific to the first time you cycled these substances. 1. How old were you when you started this first cycle? Do not consider prohormones or nutritional supplements that make claims about anabolic activity. Who, if anyone, influenced your decision to go on this first cycle? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to execute an APED cycle. 2. Coach or athletic trainer 3. Physician or medical personnel. 4. Teammate or other athlete 5. Friend or family member 6. Scout or agent 7. Advertisements 8. Celebrity (famous athlete or coach) 9. Internet advice 10. Independent or self directed years No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 1 2 3 4 5 6 7 8 9 10 41 Thinking back to this first cycle, which of the following substances did you use? **Which of the following substances did you use during your first APED cycle? (Hand the Interviewee the list of substances. If the interviewee cannot remember exact information, have him/her make their best approximation or help him/her complete calculations for dose, duration, etc.) ASK THE FOLLOWING FOR EACH ENDORSED APED **For how many days did you use____? **What was your average weekly dose? **What was the highest dose you ever took of this substance? FILL IN THE APED # FROM THE CODE SHEET AS WELL AS THE NAME. IF THE APED REPORTED IS NOT ON THE CODE SHEET, THEN FILL IN THE SUBSTANCE IN THE SPACE PROVIDED, CODE “”, AND ASK THE SAME SET OF FOLLOW-UP QUESTIONS. 42 Duration Substance # Dose Max Dose 11 days 12 /wk 13 15 15 days 16 /wk 17 18 19 days 20 /wk 21 22 23 days 24 /wk 25 26 27 days 28 /wk 29 30 31 days 32 /wk 33 34 35 days 36 /wk 37 38 39 days 40 /wk 41 42 43 Days 44 /wk 45 46 47 days 48 /wk 49 50 51 days 52 /wk 53 54 55 days 56 /wk 57 58 59 days 60 /wk 61 62 63 days 64 /wk 65 66 67 days 68 /wk 69 70 43 71 days 72 /wk 73 74 75 days 76 /wk 77 78 79 days 80 /wk 81 82 83 days 84 /wk 85 86 87 days 88 /wk 89 90 91 days 92 /wk 93 94 95 days 96 /wk 97 98 99 days 100 /wk 101 102 103 days 104 /wk 105 106 107 days 108 /wk 109 110 111 days 112 /wk 113 114 115 days 116 /wk 117 118 119 days 120 /wk 121 122 123 days 124 /wk 125 126 127 days 128 /wk 129 130 131 days 132 /wk 133 134 44 135. What was the total duration of this APED cycle, not including post-cycle drug use? days 136. APED cycle average anabolic dose? Calculate from data after interview. Mg/wk 135 136 Sometimes people who take these substances will also take other drugs or substances during their cycle or shortly after to reduce or prevent the side effects of heavy training or certain drugs. During this first cycle, did you take any of the following ancillary drugs? [HAND INTERVIEWEE ANCILLARY CODE SHEET] These substances must have been taken for the purpose of managing side effects (usually from AAS) or aspects of the training during this period (e.g., pain killers). For this question, only consider substance use that is part of the cycle or recovery from the cycle. If, for instance, a pain killer was taken continuously throughout the cycle and was also regularly used outside of the cycle, consider the use only during the actual cycle or post cycle recovery in scoring. Ancillary Drug (Code #) 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 45 154. At the peak of this cycle, how much did your strength increase? Strength should be comparative to pre-cycle strength. For example, pre-cycle bench press was 150 lbs and at peak of the cycle could bench press 200 lbs, this would reflect a 33% increase in strength (200-150 = 50; 50/150 = .333 = 33.3%.) % 154 155. How much strength did you retain after post-cycle recovery? Strength will usually reduce post-cycle and the reduction plateaus. Calculate total strength change, from pre-cycle to post-cycle plateau. % 155 156. What was your lowest body fat percentage during this cycle, if you kept track? Ask how the interviewee obtained this information (e.g., educated guess, body fat calipers, etc.). For those who have no idea code “-9”, otherwise use the interviewee’s self-rating. % 156 157. What level of body fat percentage did you maintain postcycle, if you kept track? Must have kept approximate body fat percentage for at least one month following on-cycle attempts at reduction. If interviewee was unable to maintain a specific body fat, or the interviewee was unaware of changes in body fat levels code “-9” % 157 158. How much did you spend on your first cycle, including all of the substances that you just described? $ 158 lbs 159 159. How much weight did you gain during your first cycle? 46 How much did you experience the following benefits during your first APED cycle? Use the scaling under each item to determine the extent to which the described benefit was experienced during the course of the first cycle or as an immediate result of the cycle. Be sure to note changes from pre-cycle functioning to establish relative change or experience of benefits. Also ask interviewees to place their ratings in relation to later cycles. Increased confidence in one’s abilities? This item should include non-appearance or performance enhancement domains as well, but be differentiated from appearance confidence. None Little Somewhat Very Much A Lot 0 1 2 3 4 160 Increased confidence in one’s appearance? This item should include appearance domains only. Improved relationships with others? The extent to which social interactions with others were experienced more positively. This should be coded strictly from the interviewee’s perspective and is not a rating of the appropriateness of social behavior (e.g. aggression). Improved sense of physical health or physical well-being? Only consider physical health or how well the interviewee believed the cycle led to improved physical health (e.g. less risk for obesity related disease, etc.). Reductions in negative feelings or moods such as irritability, depression, anger, or anxiety? Consider any reduction in pre-cycle negative affect state. Improved sense of accomplishment or ability to achieve one’s goals? Target the sense of ability to be goal-directed and achieve those goals, including non-appearance or performance goals. 0 1 2 3 4 0 1 2 3 4 161 162 0 1 2 3 4 163 0 1 2 3 4 164 0 1 2 3 4 165 47 Improved job-related functioning or success? Did APEDs lead to improved status at work, increased pay, productivity, or success? Improved sense of control or confidence in social situations? Consider only interpersonal interactions that occurred during the actual on-cycle phase and not social changes (e.g., finding a romantic partner) that may be attributed to the drug use, but occurred after the cycle ended. Reduction in lethargy, fatigue, physical weakness, or pain? This should not be specific to an existing injury (see next question), but more global somatic experiences related to possible depression, stress, or excess physical output (e.g., intense exercise). Improved recovery from physical injury? The first cycle may result from pressure to recover from sport or accident related injury (e.g., shoulder surgery, etc.) and be intended to speed recovery or prevent muscle wasting during recovery. Similarly, it may be used to prevent injuries related to intense training or contact in sport/activity (e.g., ultimate fighting, football, etc.) Improved performance at sport or weight training? This targets specific outcomes related to sports or weight training (e.g., winning more often). 0 1 2 3 4 166 0 1 2 3 4 167 0 1 2 3 4 168 0 1 2 3 4 169 0 1 2 3 4 170 Increased success at attracting romantic partners? This can be in the form of flirtation or actual relationships. 0 1 2 3 4 171 Increased libido? Desirable increase in sex drive, interest, or performance. 0 1 2 3 4 172 48 Increased ability to concentrate or make decisions? Overall ability to make decisions or concentrate during cycle. 0 1 2 3 4 173 Greater sense of being driven or motivated? Keep this to sense of being driven or motivated in some physical sense, not a social sense. 0 1 2 3 4 174 During this first APED cycle, which of the following side effects did you experience while you were actively “on-cycle”? (GIVE INTERVIEWEE THE LIST OF ON-CYCLE SIDE EFFECTS). Take the interviewee’s report for each item and include period of time about approximately 2 weeks after last administration. If the interviewee does not know whether they experienced this side effect (e.g., increased LFT) code “0.” Get a sense for each side effect the amount or frequency of each endorsed item. Follow-up each scalable endorsed item with: ***How much did this side effect bother you?” ***How often did this side effect occur?” Based on the answers to these questions, scale each side effect on a severity continuum using the anchors listed below. If the level of severity is unclear, code based on evidence of functional impairment over evidence of frequency, particularly for side effects that may be severe but only occur once or twice. For items that usually just occur just once or may exist but require medical examination to detect, simply code as “absent = 0” or “present = 1” 0 1 2 3 4 Not Severe Somewhat Severe Moderately Severe Very Severe Extremely Severe Side effect not experienced Evidence that the side Some evidence that the side effect occurred effect occurred regularly and was minimally impairing and occurred and/or was notably infrequently. impairing when it did occur. Evidence that the side effect occurred often and was functionally impairing when it occurred. Evidence that the side effect was persistent and impairing 49 Physical Side Effects Water retention? 0 1 2 3 4 Headaches? 0 1 2 3 4 Nosebleeds? 0 1 2 3 4 0 1 2 3 Can’t stop moving or excessive energy? 0 0 1 1 2 2 3 3 2 3 4 Diarrhea? 0 1 2 3 4 Joint pain? 0 1 2 3 4 Digestive trouble such as indigestion or excessive gas? 0 1 2 3 4 0 1 2 3 4 Nausea or vomiting? 0 1 2 3 4 0 1 2 3 4 Flu-like symptoms? 0 1 2 3 4 0 1 2 3 4 Heart palpitations? 0 1 2 3 4 Heart skips a beat? Heat intolerance? Night sweats? 0 0 0 1 1 1 2 2 2 3 3 3 0 1 2 3 4 195 180 No 0 0 Yes 1 1 2 196 3 0 1 2 3 0 1 2 3 0 1 2 3 186 0 1 2 3 4 0 1 2 3 4 0 1 203 0 1 204 0 1 0 1 206 207 Medical Consequences? 188 Verified by medical test or evaluation Increased blood Pressure 0 189 0 190 Increased liver function test Polycystic Ovarian Syndrome 0 191 Elevated cholesterol 0 4 4 4 1 208 1 209 1 210 1 192 Trouble falling or staying asleep? 0 1 2 3 4 200 Administrative-Related Side Effects? Allergic or bad reaction to injection or substance consumed Scarring from injections Extreme pain or swelling at injection site 4 199 183 Abscess at injection site 4 198 182 181 4 197 Difficulty getting an orgasm? Infertility or amenorrhea 187 Dehydration? Painful prostate? Decrease in sex drive? 185 Muscle cramps or spasms? 1 9 4 179 184 Fatigue easily? 4 Excessive sex drive Must be unwanted or undesirable Difficulty getting an erection or becoming aroused? Testicular shrinkage or clitoral Enlargement? 4 1 3 Sexual Side Effects? 4 0 2 176 4 Stomach pain? 1 175 178 Excessive sweating? 0 Muscle or tendon tear? 177 Tremors or shakiness? Sleeping too much? 211 Enlarged prostate 4 0 1 193 212 50 201 202 Heart condition? 0 1 213 Affective or Mood related Side Effects? Increased depression? 0 1 2 3 Difficulty making decisions? 0 Difficulty remembering things? 0 1 2 3 4 222 1 2 3 4 223 Unwanted Changes in Appearance? 4 214 Increased number of mood swings? 0 1 2 3 4 Panic attacks? 0 1 2 3 4 215 216 Increased irritability? 0 1 2 3 4 Lower frustration tolerance? 0 1 2 3 4 Increased aggression? 0 1 2 3 4 217 218 219 Cognitive Side Effects? Difficulty focusing or concentrating? Thoughts are racing or moving too quickly? Any other side effects: 0 1 2 3 4 0 1 2 3 4 220 221 Acne? 0 Intestinal growth? 0 1 225 Bone growth? 0 1 226 Increased hair growth (body or face)? Hair loss or baldness? Flushed face? Gynecomastia or “gyno”? Male only Loss of breast tissue? Female only Change in facial features? 1 224 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 0 1 0 1 230 231 232 233 51 227 228 229 During this first APED cycle, which of the following side effects did you experience after finishing your cycle or were “off-cycle”? (GIVE INTERVIEWEE LIST OF POST-CYCLE SIDE EFFECTS) Take the interviewee’s report for each item. If the interviewee does not know whether they experienced this side effect (e.g., increased LFT) code “-9.” Get a sense for each side effect the amount or frequency of each endorsed item. Follow-up each scalable endorsed item with: ***How much did this side effect bother you?” ***How much of the time did this side effect occur?” Based on the answers to these questions, scale each side effect on a severity continuum using the anchors listed below. If the level of severity is unclear, code based on evidence of functional impairment over evidence of frequency, particularly for side effects that may be severe but only occur once or twice. For items that usually just occur just once or may exist but require medical examination to detect, simply code as “absent = 0” or “present = 1” 0 1 2 4 5 Not Severe Somewhat Severe Moderately Severe Very Severe Extremely Severe Side effect not experienced Evidence that the side Some evidence that the side effect occurred effect occurred regularly and was minimally impairing and occurred and/or was notably infrequently. impairing when it did occur. Affective or Mood Related Side Effects? Increased Anxiety, Worry, or Fear? Increased Depression? 1 2 3 4 0 1 2 3 4 234 235 Increased number of Mood Swings? 1 2 3 4 234 Panic attacks? Increased Irritability? Lower frustration tolerance? Increased Aggression? Evidence that the side effect was persistent and impairing Other Side Effects 0 0 Evidence that the side effect occurred often and was functionally impairing when it occurred. 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 236 237 Trouble falling or staying asleep? 0 1 2 3 4 Sleeping too much? 0 1 2 3 4 0 1 2 3 4 Difficulty Concentrating or Focusing? Decrease in Sex Drive? Suicidal Thoughts? 240 241 242 0 1 0 2 3 4 1 243 244 Any other side effects? 238 239 245 52 244. During this APED cycle, at any point did you seek the help of a health professional to manage the side effects or consequences of your use? This item includes non-MD professionals including counselors, nurses, nursepractitioner, etc. No Yes 0 1 246 245. What about the help of a non-professional? Trainers, coaches, or experienced users would qualify as non-professionals. Consider friends or acquaintances that may have a medical degree, but were not providing consultation in a professional context would be a “yes” for this question. This includes internet discussion board posts. 246. What about the internet? Consider only published information. If questions were posted and answered by other users through a discussion board, code “0”. Consider only information already published on a website for this item. 0 1 247 0 1 248 247. What about print materials such as medical journals or books such as steroid bibles? This item targets the use of “steroid bibles” and others sources that provide information relevant to APED cycle and managing side effects. 0 1 249 What was the primary reason you decided to go on this first APED cycle? Identify only the primary reason for initial use. Code based on interviewee response. Provide examples from the list if the interviewee can’t remember. No Yes To treat injury or illness? 0 1 To prevent injury, illness, or promote overall health and well being? 0 1 To improve athletic or job related performance? 0 1 To improve physical appearance or increase level of attractiveness? 0 1 To intimidate or fight better? 0 1 To improve feelings about oneself? 0 1 250 251 252 253 254 255 53 Other (Specify): 0 1 256 255. During your first cycle, how satisfied with the effects of these substances were you? Try to keep the satisfaction rating specific to effects the interviewee attributes to the drugs themselves and not the effects of diet or training during the cycle. Not at All Satisfied A little Satisfied Somewhat Satisfied Moderately Satisfied Notably Satisfied Very Satisfied Extremely Satisfied 0 1 2 3 4 5 6 257 54 CURRENT OR MOST RECENT APPEARANCE AND PERFORMANCE ENHANCING DRUG CYCLE We will focus now on your current APED cycle or the most recent APED cycle you have completed. Do not include creatine, protein supplements, or similar nutritive products. The APED cycle we are targeting must have included, at some point, an illegal anabolic agent and/or an illegal fat-burner or endurance booster. No Yes 0 1 1. Are you currently on-cycle? The interviewee must have recently taken an APED and plan on taking an APED sometime after this interview to be considered on-cycle. If the interviewee has recently (within 2 weeks) taken their last APED and is entering the post-cycle phase of their pattern, do NOT code “1”. 2. When did you start this most recent/current cycle? 1 Mo Day Yr Mo Day Yr Mo Day Yr Do not consider prohormones or nutritional supplements that make claims about anabolic activity. 3. When did this most recent cycle end? Are you bridging? 2 Consider the end of the cycle as when the last dose of an illicit APED was taken. If the interviewee is currently “bridging” and considers his/her cycle over but continues to take APEDs (e.g., low dose of testosterone) use the interviewee’s identification of the last day of the cycle. 3 4. When do you expect your current cycle to end? [Only if on-cycle] For those currently “on cycle”, record the day they plan on finishing their current cycle. Do not include “bridging” in the cycle definition. If there is no planned finish date or it is unknown, code “-9” for Month, Day, and Year. 4 55 Who, if anyone, influenced your decision to go on this current/most recent cycle? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to execute an APED cycle. 5. Coach or athletic trainer 6. Physician or medical personnel. 7. Teammate or other athlete 8. Friend or family member 9. Scout or agent 10. Advertisements 11. Celebrity (famous athlete or coach) 12. Internet advice 13. Independent or self-directed No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 5 6 7 8 9 10 11 12 13 Thinking back to this current/most recent cycle, which of the following substances did you use? (Hand the Interviewee the list of substances. If the interviewee cannot remember exact information, have him/her make their best approximation or help him/her complete calculations for dose, duration, etc.) ASK THE FOLLOWING FOR EACH ENDORSED APED **For how many days did you use____? **What was your average weekly dose? **What was the highest dose of this substance that you used during this cycle? FOR APEDS THAT ARE NOT USED CODE “-9” IF THE APED REPORTED IS NOT ON THE LIST HAVE THE INTERVIEWEE FILL IN THE SUBSTANCE IN THE “OTHER” BOX AND ASK THE SAME SET OF FOLLOW-UP QUESTIONS. 56 Substance (Code #) Duration Dose Max Dose 14 days 15 /wk 16 17 18 days 19 /wk 20 21 22 days 23 /wk 24 25 26 days 27 /wk 28 29 30 days 31 /wk 32 33 34 days 35 /wk 36 37 38 days 39 /wk 40 41 42 days 43 /wk 44 45 46 Days 47 /wk 48 49 50 days 51 /wk 52 53 54 days 55 /wk 56 57 58 days 59 /wk 60 61 62 days 63 /wk 64 65 66 days 67 /wk 68 69 70 days 71 /wk 72 73 57 74 days 75 /wk 76 77 78 days 79 /wk 80 81 82 days 83 /wk 84 85 86 days 87 /wk 88 89 90 days 91 /wk 92 93 94 days 95 /wk 96 97 98 days 99 /wk 100 101 102 days 103 /wk 104 105 106 days 107 /wk 108 109 110 days 111 /wk 112 113 114 days 115 /wk 116 117 118 days 119 /wk 120 121 122 days 123 /wk 124 125 126 days 127 /wk 128 129 130 days 131 /wk 132 133 134 days 135 /wk 136 137 58 138. What was the total duration of this APED cycle, not including post-cycle drug use? days 138 139. APED cycle average anabolic dose? Mg/wk 139 Sometimes people who take these substances will also take other drugs or substances during their cycle or shortly after to reduce or prevent the side effects of heavy training or certain drugs. During this cycle, did you take any of the following ancillary drugs? [HAND INTERVIEWEE ANCILLARY CODE SHEET] These substances must have been taken for the purpose of managing side effects (usually from AAS) or aspects of the training during this period (e.g., pain killers). For this question, only consider substance use that is part of the cycle or recovery from the cycle. If, for instance, a pain killer was taken continuously throughout the cycle and was also regularly used outside of the cycle, consider the use only during the actual cycle or post cycle recovery in scoring. Ancillary (Code #) 140 141 142 143 144 145 146 147 148 150 150 151 152 153 154 155 156 59 157. At the peak of this cycle, how much did your strength increase? Strength should be comparative to pre-cycle strength. For example, pre-cycle bench press was 150 lbs and at peak of the cycle could bench press 200 lbs, this would reflect a 33% increase in strength (200-150 = 50; 50/150 = .333 = 33.3%.) If the cycle is active, get rating of current strength increase. % 157 158. How much strength did you retain after post-cycle recovery? Strength will usually reduce post-cycle and the reduction plateaus. Calculate total strength change, from pre-cycle to post-cycle plateau. Code ‘-9’ if cycle is still active. % 158 159. What was your lowest body fat percentage during this cycle? Ask how the interviewee obtained this information (e.g., educated guess, body fat calipers, etc.). For those who have no idea code “-9”, otherwise use the interviewee’s self-rating. Code current body fat if lowest since cycle started. % 159 160. What level of body fat percentage did you maintain postcycle? Must have kept approximate body fat percentage for at least one month following on-cycle attempts at reduction. If interviewee was unable to maintain a specific body fat, the interviewee was unaware of changes in body fat levels, or is still “on-cycle” code “-9” % 160 161. How much did you spend on the substances we just described? $ 161 lbs 162 162. How much weight did you gain? 60 To what degree did you experience the following benefits during this current/most recent cycle? Use the scaling under each item to determine the extent to which the described benefit was experienced during the course of the cycle or as an immediate result of the cycle? Be sure to note changes from pre-cycle functioning to establish relative change or experience of benefits. Increased confidence in one’s abilities? This item should include non-appearance or performance enhancement domains as well, but be differentiated from appearance confidence. None Little Somewhat Very Much A Lot 0 1 2 3 4 163 Increased confidence in one’s appearance? This item should include appearance domains only. Improved relationships with others? The extent to which social interactions with others were experienced more positively. This should be coded strictly from the interviewee’s perspective and is not a rating of the appropriateness of social behavior (e.g. aggression). Improved sense of physical health or physical well-being? Only consider physical health or how well the interviewee believed the cycle led to improved physical health (e.g., less risk for obesity related disease, etc.). Reductions in negative feelings or moods such as irritability, depression, anger, or anxiety? Consider any reduction in pre-cycle negative affect state. Improved sense of accomplishment or ability to achieve one’s goals? Target the sense of ability to be goal-directed and achieve those goals, including non-appearance or performance goals. 0 1 2 3 4 0 1 2 3 4 164 165 0 1 2 3 4 166 0 1 2 3 4 167 0 1 2 3 4 168 61 Improved job-related functioning or success? Did APEDs lead to improved status at work, increased pay, productivity, or success? Improved sense of control or confidence in social situations? Consider only interpersonal interactions that occurred during the actual on-cycle phase and not social changes (e.g., finding a romantic partner) that may be attributed to the drug use, but occurred after the cycle ended. Reduction in fatigue, physical weakness, or pain? This should not be specific to an existing injury (see next question), but more global somatic experiences related to possible depression, stress, or excess physical output (e.g., intense exercise). Improved recovery from physical injury? The first cycle may result from pressure to recover from sport or accident related injury (e.g., shoulder surgery, etc.) and be intended to speed recovery or prevent muscle wasting during recovery. Similarly, it may be used to prevent injuries related to intense training or contact in sport/activity (e.g., ultimate fighting, football, etc.) Improved performance at sport or weight training? This targets specific outcomes related to sports or weight training (e.g., winning more often). 0 1 2 3 4 169 0 1 2 3 4 170 0 1 2 3 4 171 0 1 2 3 4 172 0 1 2 3 4 173 Increased success at attracting romantic partners? This can be in the form of flirtation or actual relationships. 0 1 2 3 4 174 62 Increased libido? Desirable increase in sex drive, interest, or performance. 0 1 2 3 4 175 Increased ability to concentrate or make decisions? Overall ability to make decisions or concentrate during cycle. 0 1 2 3 4 176 Greater sense of being driven or motivated? Keep this to sense of being driven or motivated in some physical sense, not a social sense. 0 1 2 3 4 177 During this current/most recent APED cycle, which of the following side effects did you experience while you were actively “on-cycle”? [GIVE INTERVIEWEE THE LIST OF ON-CYCLE SIDE EFFECTS]. Take the interviewee’s report for each item and include period of time about approximately 2 weeks after last administration. If the interviewee does not know whether they experienced this side effect (e.g., increased LFT) code “0.” Get a sense for each side effect the amount or frequency of each endorsed item. Follow-up each scalable endorsed item with: ***How much did this side effect bother you?” ***How much of the time did this side effect occur?” Based on the answers to these questions, scale each side effect on a severity continuum using the anchors listed below. If the level of severity is unclear, code based on evidence of functional impairment over evidence of frequency, particularly for side effects that may be severe but only occur once or twice. For items that usually just occur just once or may exist but require medical examination to detect, simply code as “absent = 0” or “present = 1” 0 1 2 4 5 Not Severe Somewhat Severe Moderately Severe Very Severe Extremely Severe Side effect not experienced Evidence that the side Some evidence that the side effect occurred effect occurred regularly and was minimally impairing and occurred and/or was notably infrequently. impairing when it did occur. Evidence that the side effect occurred often and was functionally impairing when it occurred. Evidence that the side effect was persistent and impairing 63 Physical Side Effects Water retention? 0 1 2 3 4 Headaches? 0 1 2 3 4 Nosebleeds? 0 1 2 3 4 0 1 2 3 Can’t stop moving or excessive energy? 0 0 1 1 2 2 3 3 2 3 4 Diarrhea? 0 1 2 3 4 Joint pain? 0 1 2 3 4 Digestive trouble such as indigestion or excessive gas? 0 1 2 3 4 Fatigue easily? 0 1 2 3 4 Nausea or vomiting? 0 1 2 3 4 1 2 3 4 Flu-like symptoms? 0 1 2 3 4 0 1 2 3 4 Heart palpitations? 0 1 2 3 4 Heart skips a beat? Heat intolerance? Night sweats? 0 0 0 1 1 1 2 2 2 3 3 3 0 1 2 3 4 198 183 No 0 0 Yes 1 1 2 199 3 0 1 2 3 0 1 2 3 0 1 2 3 189 0 1 2 3 4 0 1 2 3 4 0 1 206 0 1 207 0 1 0 1 208 209 Medical Consequences? 191 Verified by medical test or evaluation Increased blood Pressure 0 192 0 193 Increased liver function test 0 194 Polycystic Ovarian Syndrome Elevated cholesterol 0 4 4 4 1 210 1 211 1 212 1 195 Trouble falling or staying asleep? 0 1 2 3 4 203 Administrative-Related Side Effects? Allergic or bad reaction to injection or substance consumed Scarring from injections Extreme pain or swelling at injection site 4 202 186 Abscess at injection site 4 201 185 184 4 200 Difficulty getting an orgasm? Infertility or amenorrhea 190 Dehydration? Painful prostate? Decrease in sex drive? 188 0 1 9 7 182 187 Muscle cramps or spasms? 4 Excessive sex drive Must be unwanted or undesirable Difficulty getting an erection or becoming aroused? Testicular shrinkage or clitoral Enlargement? 4 1 3 Sexual Side Effects? 4 0 2 179 4 Stomach pain? 1 178 181 Excessive sweating? 0 Muscle or tendon tear? 180 Tremors or shakiness? Sleeping too much? 213 Enlarged prostate 4 0 1 196 214 64 204 205 Heart condition? 0 1 215 Affective or Mood related Side Effects? Increased depression? 0 1 2 3 Difficulty making decisions? 0 Difficulty remembering things? 0 1 2 3 4 224 1 2 3 4 225 Unwanted Changes in Appearance? 4 216 Increased number of mood swings? 0 1 2 3 4 Panic attacks? 0 1 2 3 4 217 218 Increased irritability? 0 1 2 3 4 Lower frustration tolerance? 0 1 2 3 4 Increased aggression? 0 1 2 3 4 219 220 221 Cognitive Side Effects? Difficulty focusing or concentrating? Thoughts are racing or moving too quickly? Any other side effects: 0 1 2 3 4 0 1 2 3 4 222 223 Acne? 0 Intestinal growth? 0 1 227 Bone growth? 0 1 228 Increased hair growth (body or face)? Hair loss or baldness? Flushed face? Gynecomastia or “gyno”? Male only Loss of breast tissue? Female only Change in facial features? 1 226 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 0 1 0 1 232 233 234 235 65 229 230 231 During this current/most recent APED cycle, which of the following side effects did you experience after finishing your cycle or were “off-cycle”? [GIVE INTERVIEWEE LIST OF POST-CYCLE SIDE EFFECTS] Take the interviewee’s report for each item. If the interviewee does not know whether they experienced this side effect (e.g., increased LFT) code “0.” Get a sense for each side effect the amount or frequency of each endorsed item. Follow-up each scalable endorsed item with: ***How much did this side effect bother you?” ***How much of the time did this side effect occur?” Based on the answers to these questions, scale each side effect on a severity continuum using the anchors listed below. If the level of severity is unclear, code based on evidence of functional impairment over evidence of frequency, particularly for side effects that may be severe but only occur once or twice. For items that usually just occur just once or may exist but require medical examination to detect, simply code as “absent = 0” or “present = 1” 0 1 2 4 5 Not Severe Somewhat Severe Moderately Severe Very Severe Extremely Severe Side effect not experienced Evidence that the side Some evidence that the side effect occurred effect occurred regularly and was minimally impairing and occurred and/or was notably infrequently. impairing when it did occur. Affective or Mood Related Side Effects? Increased Anxiety, Worry, or Fear? Increased Depression? 1 2 3 4 0 1 2 3 4 236 237 Increased number of Mood Swings? 1 2 3 4 238 Panic attacks? Increased Irritability? Lower frustration tolerance? Increased Aggression? Evidence that the side effect was persistent and impairing Other Side Effects 0 0 Evidence that the side effect occurred often and was functionally impairing when it occurred. 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 239 240 Trouble falling or staying asleep? 0 1 2 3 4 Sleeping too much? 0 1 2 3 4 0 1 2 3 4 Difficulty Concentrating or Focusing? Decrease in Sex Drive? Suicidal Thoughts? 243 244 245 0 1 0 2 3 1 4 246 7 247 Any other side effects? 241 242 248 66 246. During this current/most recent APED cycle, at any point did you seek the help of a health professional to manage the side effects or consequences of your use? This item includes non-MD professionals including counselors, nurses, nursepractitioner, etc. No Yes 0 1 249 247. What about a non-professional? Trainers, coaches, or experienced users would qualify as non-professionals. Consider friends or acquaintances that may have a medical degree, but were not providing consultation in a professional context would be a “yes” for this question. This includes internet discussion board posts. 0 1 250 248. What about the internet? Consider only published information. If questions were posted and answered by other users through a discussion board, code “0”. Consider only informational already published on a website for this item. 0 1 251 249. What about print materials such as medical journals, or books such as “steroid bibles”? This item targets the use of “steroid bibles” and others sources that provide information relevant to APED cycle and managing side effects. 0 1 252 67 What was the primary reason you decided to go on this APED cycle? Identify only the primary reason for initial use. Code based on interviewee response. Provide examples from the list if the interviewee can’t remember. No Yes To treat injury or illness? 0 1 To prevent injury, illness, or promote overall health and well being? 0 1 To improve athletic or job related performance? 0 1 To improve physical appearance or increase level of attractiveness? 0 1 To intimidate or fight better? 0 1 To improve feelings about oneself? 0 1 Other (Specify): 0 1 253 254 255 256 257 258 259 257. During current/most recent cycle, how satisfied with the effects of these substances were you? Try to keep the satisfaction rating specific to effects the interviewee attributes to the drugs themselves and not the effects of diet or training during the cycle. Not at All Satisfied A little Satisfied Somewhat Satisfied Moderately Satisfied Notably Satisfied Very Satisfied Extremely Satisfied 0 1 2 3 4 5 6 260 68 USUAL APED USE CYCLE Only enter this section for someone who has completed at least 3 APED cycles. We will focus now on your usual pattern of APED use and attempt to get a general sense of your experience with APEDS. Do not include creatine, protein supplements, or similar nutritive products. The APED cycle we are targeting must have included, at some point, an illegal anabolic agent and/or an illegal fat-burner or endurance booster. 1. How many APED cycles have you completed? Do not consider prohormones or nutritional supplements that make claims about anabolic activity. 2. What was the average duration between cycles? Consider the end of the cycle as when the last dose of an illicit APED was taken. If the interviewee has a history of “bridging” between cycles, consider the duration between actual cycles Who, if anyone, typically influences your decision to go on-cycle? If there was more than one primary influence have the participant choose which source was most influential about the DECISION to execute an APED cycle. 3. Coach or athletic trainer 4. Physician or medical personnel. 5. Teammate or other athlete 6. Friend or family member 7. Scout or agent 8. Advertisements 9. Celebrity (famous athlete or coach) 10. Internet advice 11. Independent or self-directed cycles 1 wks 2 No Yes 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 3 4 5 6 7 8 9 10 11 69 Thinking back across all of your cycles, which of the following substances have you used? (Hand the Interviewee the list of substances. If the interviewee cannot remember exact information, have him/her make their best approximation as to the substances used. If the list of substances used across all cycles is particularly long, it may be more helpful to have them just list the assigned number on the list). FOR APEDS THAT ARE NOT USED CODE “-9” IF THE APED REPORTED IS NOT ON THE LIST, WRITE THE SUBSTANCE IN THE “OTHER” BOX AND ASK THE SAME SET OF FOLLOW-UP QUESTIONS. 70 Substance (Code #) cont Substance (Code #) Substance (Code #) cont 1 16 31 2 17 32 3 18 33 4 19 34 5 20 35 6 21 36 7 22 37 8 23 38 9 24 39 10 25 40 11 26 41 12 27 42 13 28 43 14 29 44 15 30 45 71 Sometimes people who take these substances will also take other drugs or substances during their cycle or shortly after to reduce or prevent the side effects of heavy training or certain drugs. Which of these substances do you typically use? [HAND INTERVIEWEE ANCILLARY CODE SHEET] These substances must have been taken for the purpose of managing side effects (usually from AAS) or aspects of the training during this period (e.g., pain killers). For this question, only consider substance use that is part of the cycle or recovery from the cycle. If, for instance, a pain killer was taken continuously throughout the cycle and was also regularly used outside of the cycle, consider the use only during the actual cycle or post cycle recovery in scoring. Ancillary (Code #) 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 72 Social APED Context The following questions will pertain to your general experience as an APED user and the degree to which your APED use is connected to a community or culture of APED use. 1. How often do you discuss APED use with people you know well? This questions targets people who are known by the individual and who he/she may spend time with outside of drug use (e.g., friends, family members, etc.) Never 0 Never Seldom 1 ~1x/mo Sometimes 2 ~1x/wk Frequently 3 ~several times/wk Always 4 daily 1 2. How often do you discuss APED use with people you only know through the internet or through your APED use? This questions targets contact with people who are anonymous or not known well but may share knowledge, expertise, or common experiences with regard to training, dietary practices, or drug use. Never 0 Never Seldom 1 ~1x/mo Sometimes 2 ~1x/wk Frequently 3 ~several times/wk Always 4 daily 2 3. How much does your APED use conform to that of others you know who use APEDs? Consider how much the pattern, types, dose/amt of APEDs is similar to others that they know who use APEDs. Keep in mind this may be because others follow his/her lead or because he/she is following the lead of someone else. Not at all 0 Very little 1 Somewhat 2 Very much 3 Completely 4 73 3 4. How often do you give advice or provide counsel to other APED users regarding their use patterns, maximizing the effects of a cycle, or managing side effects? This question targets the degree to which the interviewee is an expert in his/her use and one who shares this knowledge with others. Consider only the amount of time spent in this mentorship like role and consider this role both through anonymous contact over the internet as well as in person contact. Never 0 No evidence of providing info to others about use Seldom 1 Sometimes 2 Frequently 3 Will on occasion provide guidance or information, but usually avoids these situations. Will provide information on at least a weekly basis to others. Clear mentorship like roles in APED use, with frequent advice or direction to others. Always 4 4 Provides mentorship to a large number of users or is directly advising or coaching an APED user in every aspect of APED use. 5. How often do you share your supply or help others source APEDs? This question targets the interviewee’s role as a gateway to others’ APED use. Any evidence of having helped others obtain APEDs or of sharing APEDs of others code > 0. Never 0 Never Seldom 1 ~1x/mo Sometimes 2 ~1x/wk Frequently 3 ~several times/wk Always 4 daily 5 6. How many people do you know who use APEDs? Report only those people who the interviewee knows well. 6 7. How do you source your APEDs? . Friend/ Internet Source/ Family Dealer 0 1 2 Prescription Vet Supply 3 4 Legal Source 5 74 7 RISK AND FUTURE USE The following questions will pertain to your intentions for future APED use as well as circumstances where you are likely to stop or continue to use APEDs. 1. If you were given indisputable evidence that APED use leads to severe long term consequences, what is the likelihood that you would continue to use APEDs? Not at all Likely 0 Unlikely 1 Ambivalent 2 Probably 3 Absolutely 4 1 2. In order to reach your training, appearance, or performance related goals, how many years of your life would you sacrifice? years 2 3. For how long do you plan on continuing to use APEDs? Calculate based on interviewee’s best estimate. Never again <5 more years 5-10 years 0 1 2 >10 years, but not forever 3 4. If you drink alcohol, which is more important to you, or which would you preserve, if you could only preserve one?... APED use or drinking? For the rest of my life 4 N/A APED Alcohol -9 0 1 Code “-9” if individual does not drink or does not plan on ever using APEDs again. 3 4 75 N/A APED Other Drugs -9 0 1 5. If you use recreational drugs, which is more important to you, or which would you preserve, if you could only preserve one?... APED use or Other Drug Use? Code “-9” if individual does use other drugs or does not plan on ever using APEDs again. 5 N/A No Yes -9 0 1 6. Have you ever gotten in trouble with the law for your APED use? Code “-9” if individual has only used APEDs in a legal context (e.g. in a country where these drugs are purchased legally). 6 N/A No Yes -9 0 1 7. Would getting in trouble with the law deter your future use of APEDs? Code “-9” if individual does use other drugs or does not plan on ever using APEDs again. 8. Have you ever used any “underground gear” or homemade APEDs? 7 N/A No Yes -9 0 1 Code “-9” if the interviewee is unsure. 9. Have you ever gotten in trouble with your spouse or partner because of your APED use? 8 N/A No Yes -9 0 1 Code “-9” if individual has never had a spouse or partner.. 9 N/A No Yes -9 0 1 10. Would getting in trouble with your spouse or partner deter your future APEDs? Code “-9” if individual does use other drugs or does not plan on ever using APEDs again. 11. Have you ever gotten in trouble at work or school because of your APED use? 10 -9 0 1 Code “-9” if individual is not engaged in work or school. 11 76 N/A No Yes -9 0 1 12. Would getting in trouble at work or school deter your future use of APEDs? Code “-9” if individual does use other drugs or does not plan on ever using APEDs again. 12 N/A No Yes -9 0 1 13. Have you ever used a masking agent or scheduled your APED doses to evade a drug testing program? Code “-9” if individual has not ever been in a circumstance where drug testing was possible. 13 N/A No Yes -9 0 1 14. Do you think that APEDs should be legalized? Code “-9” if individual has not ever been in a circumstance where drug testing was possible. 14 N/A No Yes 15. What is the youngest age at which an athlete should consider using APEDs? Code “-9” if individual believes that there should be no age restriction at all. Years 77 15 Steroidal Anabolics Code # 1 2 3 Primary Trade/Street Name(s) Anadrol (oral) Anatrofin Anavar Generic Names Oxymetholone Stenbolone acetate Oxandrolone 4 5 Andractim, “DHT” Andriol Dihydrotestosterone Testosterone undecanoate 6 Androderm (patch) Testosterone 7 8 9 Androgel (gel) Cheque drops Deca-Durabolin, “Deca” Testosterone Mibolerone Nandralone decanoate 10 Dianabol, “D-bol” Methandrostenolone 11 Diandrol Nandralone deconate + nandrolone phenylpropionate Trade Names Anadrol-50 Anatrofin Anatrophill, Anavar, Bonavar, Kicker Tab, Lipidex, Lonavar, Oxafort, Oxanabol, Oxandrin, Oxandro tabs, Oxandro 10, Oxandrolone SPA, Oxandrovet, Oxavet QV Andractim Andriol, Androxon, Nuvir, Panteston, Restandol, Sustenan Oral, Undestor, Virigen Androderm, Andropatch, Atmos, Testoderm, Testum Androgel, Androtop Gel, Testogel Mibolerone, Mibolerone drops, Cheque drops Anabolicum, Anabolin Forte, Anaboline Depot, Anaprolina, Androlone-D 200, Canoate inj, Deca 300, Deca QV 200 or 300, Decabol, Deca-Dubol-100, Deca-Durabolin, Deca-Evabolin, Decagic, Decanadrolen, Decandrol 300, Decaneurabol, Decaneurophen, Decanofort, Decatron 250, Dimetabol, Dynabolon, Elpihormon, Extraboline, Gerabolin, Hybolin Decanoate, Jebolan, Metadec, Myobolin, Nandraboli L.A., Nandralone 300 L.A., Nadrosande, Neo-Durabolic, Norandren, Nurezan, Retabolil, Retabolin, RWR Deca 50, Sterobolin, Ziremilon D-Bol, Dialone, Dianabol, Encephan, Genabol, Melic, Metaboline, Metanabol, Mentadienon, Metandiol 60, Mentandrol 10, Metandrostenolon, Methan Tabs, Methanabol, Methandienone, Methandon, Naposim, NeoAnabolene, Nerobol, Pronabol-5, Reforvit, Restauvit, Stenolon, Trinergic Diandrol 78 12 13 Drive Durabolin boldenone + methylandrostenediol Nandralone phenylpropionate 14 15 Dynabolon Equilon 100 16 Equipoise “EQ” Nandralone undecanoate Boldenone Acetate + Boldenone Proprionate + Boldenone Undecylenate + Boldenone Cypionate Boldenone Undecylenate 17 Equitest 200 18 19 20 Esiclene Norbolethone Halotestin 21 22 23 Hydrotestosterone Laurabolin Libriol 24 Masteron Testosterone Acetate + Testosterone Proprionate + Testosterone Phenylpropionate + Testosterone Caproate + Testosterone enanthate + Testosterone cypionate + testosterone decanoate Formebolone Norbolethone Fluoxymesterone Drive Actovin, Anabolin, Andralone, Daily Reborn, Dubol-50 100, Durabol, Equibolin-50, Estigor, Evabolin, Fenobolin, Fherbolico, Ganekyl, Hybolin, Macrabone, Menablin, Metabol, Metrobolin, Nandrobolic, Nandrolin, Nerobolil, Neurabol, Neurophen, Norabon, Nu-Bolic, Protosin, Rubolin, Sinbolin, Superanabolon, Turinabol Dynabolon, Psychobolan Equilon 100 Ana-Bolde, Anabolic-BD, Bold 200, Bold QV 200, Boldabol, Boldabol, Boldabol-H, Boldenol 25, Boldenol R, Boldenon, Boldenona, Boldenona 50, Boldenone-50, Cebulin 50, Crecibol, Dynabolin 50, Equifort, Equi-gan, Equipoise, Ex-pois, Ganabol, Legacy, Maxigan, Mitgan 50, Porkybol 1%, Sybolin, Ultragan, Vebonol Equitest 200 Esiclene, Hubernol No Commercial Production Android-F, Baojen, Chinglicosan, Ferona, Fosteron, Fu Lao Shu, Halotestin, Hysterone, Lipaw, Long, ODK, Oralsterone, Ora-Testryl, Sidomon, Stenox, Tealigen, Ton Lin, Ultandren, Vewon, Vi Jane, Waromom 4-hydrotestosterone No Commercial Production Nandrolone laurate Fortabol, Fortadex, Laudrol LA, Laurabolin Nandralone phenylpropionate + methandriol Libriol dipropionate Drostanolone propionate Dromostan, Drolban, Mastabol, Masterid, 79 25 Megagrisevit-Mono Clostebol acetate 26 Mestanolone Mestanolone 27 Methandriol Methylandrostenediol 28 29 30 31 Methyl-1-testosterone Methyldienolone Methylhydroxnandrolone, “MHN” Methyltestosterone “Methyl-Test” Methyl-1-testosterone Methyldienolone Methylhydroxnandrolone Methyltestosterone 32 33 34 35 36 37 Metribolone Miotolan Myagen Neotest 250 Nilevar Omnadren 38 Orabolin Methyltrienolone Furazibol Bolasterone Testosterone decanoate Northandrolone Testosterone propionate + testosterone phenylpropionate + testosterone isocaproate + testosterone caproate Ethylestrenol 39 40 41 Oranabol Parabolan Primobolan (oral) “Primo” Oxymesterone Trenbalone hexahydrobenzylcarbonate Methenolone acetate 42 43 44 Primobolan Depot (injectible) “Primo” Protabol Proviron Methenolone enanthate Thiomesterone Mesterolone 45 46 Sanabolicum Spectriol Nandrolone cyclohexylpropionate Methandriol Dipropionatye + Nandrolone Masteril, Mastisol, Metormon, Permastril Steranabol, Trofodermin Crema, Trofodermin Spray No Commercial Production Andris, Methyldiol, Methydiol Aqueous, Methyladnrostendiol, Novandrol No Commercial Production No Commercial Production No Commercial Production Afro, Agovirin, Android, Androral, Arcosterone, Debosteron, Geri Tabs, Giando Stridox, Hormobin, KangJungBing, Longivol, Mediatric, Mesteron, Metandren, Metesto, Metil Testosterone, Neo Aphro, Oreton, Oreton Methyl, T. Lingvalete, Testo Tab, Teston, Testopropon, Testormon, Testosteron, Testred, Virilon Metribolone Miotolan Myagen Neotest 250 Anaplex, Nilevar Omandren Maxibolin, Nandoral, Orabol-H, Orabolin, Orgabolin, Silabolin No Commercial Production Danabolan, Parabolan, Trenabol Depot Metabolon 25, Menetol QV, Primobolan, Primo-Plus 50 Primobol, Primo Plus 100, Suprimo 100 Emdabolin Mesterolon, Mestoranum, Plurviron, Proviron, Provironum, Restore, Vistamon Sanabolicum Spectriol 80 47 Sten 48 Steranabol Ritardo 49 Sustanon ‘100’ 50 Sustanon ‘250’ 51 52 Synovex Test 400 53 54 55 56 57 Testolent Testosterone buciclate Testosterone butyrate Testosterone cyclohexylpropionate, “CHP” Testosterone cypionate, “cyp,” “TC” 58 Testosterone enanthate, “TE” phenylpropionate + Testosterone proprionate + testosterone cypionate + testosterone hexahydrobenzoate Testosterone cypionate + Testosterone propionate Oxabolone cypionate Testosterone propionate + testosterone phenylpropionate + testosterone isocaproate Testosterone propionate + testosterone phenylpropionate + testosterone isocaproate + testosterone decanoate Testosterone propionate + estradiol Testosterone proprionate + testosterone cypionate + testosterone enanthate Testosterone phenylpropionate Testosterone buciclate Testosterone butyrate Testosterone cyclohexylpropionate Testosterone cypionate Testosterone enanthanate Sten Steranabol Ritardo Sustanon ‘100’ Andropen 275, Durandron, Polysteron, Sostenon, Sustanon ‘250’, Teston 250, TestoJet LA, Testosteron, Testonon ‘250’, Sustaretard ‘250’ Synovex Test 400 Testolent Testosterone buciclate Testosterone butyrate Testosterone CHP, Theramex Anabolic TL, Andro-Cyp, Andronaq LA, Anronate, Banrot, Biselmon Depot, CycloTestosterone Depot, Cypionax, Cypiotest 250, Cypriotest L/A, Dep Andro 100-200, DepotBifuron, Depo TCP, Depotest, Depo Testermon, Depo-Testosterone, Depot Hormon MF, Depotrone, Depovirin, D-Test 100-200, Duratest 100-200, Malogen Cyp, Miro Depo, Nannismon Depot, Ridrot Testosterone, Sheinpharma Testone-Cyp, Testabol Depot, Testa-C, Testa-cyp, Testadiate-Depo, Testex Leo prolongatum, Testo LA, Testoject, Testoject 50. Teston QV 200, Testerona Ultra Lenta, Testred Cypionate, Vironate Neotest ‘250’, Anderone 100/200, Andro 100, Andro LA, Andropository, Androtardyl, 81 Andryl 200, Delatest, Delatestryl, Depo Testmon Inj, Dura Testosterone, Durathate200, Enantat QV-250-350, Enatesto 250, Enamon-250, Everone, Jenasteron Inj, Malogen, Malogex 250 LA, PrimotestonDepot, Ropel Liquid Testosterone, Sunamon Inj, Tesone LA, Testanate No 1, Testaval, Testen-250, Testenan, Testermon, Testen 59 Testosterone propionate, “Prop”, “TP” Testosterone propionate 60 Testosterone suspension Testosterone 61 Testoviron 62 63 THG Trenbolone “Tren-A”, “Fina” Testosterone propionate + testosterone enanthate Tetrahyrdogestrinone Trenbolone acetate 64 65 Trenbolone “Tren-E” Tribolin Trenbolone enanthate Nandrolone decanoate and Methandriol dipropionate Agovirin, Anatest, Androfort-Richter, Androlan, Ara-Test, Astrapin, AVP Supertest, Dubol, Facovit, Hybolin Imp, Malogen + Oil, Nansom Depot, Neo-Hombreol, Oreton, Propionat QV 100, Propiotest, Tepro Hormone, Testabol Proprionate Testex Leo, Testo, Testogan, Testolic, Testone-E, Testopin-100, Testopro L/A, Testosteron, Testosteron Depot, Testosterona, Testosterone Jenapharm, Testosterone Streuli, Testostoviron, Testovis, Triloandren, Viromone, Implus-H, Progo-H, VR Testprop, Synovex-H Anabolic-TS, Androlan Aqueous, Androlin, Andronaq-50, Aqua Test, Histerone Injection, Malogen, Malogen Aqueous, Malatrone, RWR Suspension, Tesamone, Testolin, Testos 100, Testosus 100, Veto-Test Sus, Agovirin-Depot Testoprim-D THG Acetrenbo 50, ComponentTE-G, ComponentTE-S, ComponentT-H, ComponentT-S, Finaject, Finajet, Finaplix-H, Finaplix-S, Parabolan Tabs, Revalor-200, Revalor-H, Revalor-IH, Revalor-S, Synovex plus, Trembolone QV 75, Trenbo 75, Trenol 50 Trenbolone enanthate Tribolin 82 66 Trinabol 150 67 Triolandren 68 69 Turinabol (oral) Winstrol (oral) “winny”, “Win-V” Trenbolone acetate + Trenbolone hexahydrobenzylcarbonate + Trenbalone enanthate Testosterone propionate + Testosterone-nvalerianate + Testosterone Undecylenate 4-chlorodehydromethyltestosterone Stanozolol 70 Winstrol (injectible) “winny”, “Win-V” Stanozolol Trinabol 150 Triolandren Turinabol, T-bol Anazol, Apetil, Cetabon, Estano-Pet’s, Menabol, Neurabol, Seidon, Stan QV 10, Stan Tabs, Stanabol, Stanazolic, Stanol, Stanol 10, Stanol V, Stanozodon, Stanozolol, Stanzol, Stromba, Terabon, Winstrol, Winstrol V Anabolic ST, Anabolico Produvet, Estanozolol, Estrombol, Nabolic, Nabolic Strong, Stan 50, Stan QV 50-100, Stanabolic, Stanazol, Stanazolic, Stanol 50, Stanol-V, Stanosus, Stromba, Strombaject, Tanoxol, Vitabolic, Winstrol Depot, Winstrol V Non-Steroidal Anabolics Code # 71 72 73 Generic Names Clonidine hydrochloride Metformin Hcl Sermorelin acetate Trade Names Catapres Glucaphage 74 Primary Trade/Street Name(s) Catapres Glucaphage Growth Hormone-Releasing Hormone “GH-RH” Human Growth Hormone “HGH” Somatropin 75 Insulin, “Slin” Insulin 76 77 78 Insulin Like Growth Factor, “IGF-1” Protropin Kynoselen 79 80 Lutalyse Rezulin Insulin Like Growth Factor 1 Sontrem Heptaminol + Adenosine monophosphate + Vitamin B-12 + Sodium selenite + magnesium aspirate + potassium aspartate Prostaglandin F2Alpha, diniprost Troglitazone Humatrobe, Jin Tropin rHGH, Nutropin AQ, Saizen, Serostim, Nutropin Depot Humalin, Humalog, Humalin-N, NPH, Humalin-L, Humalin-U IGtropin Fitropin Kynoselen Code # Primary Trade/Street Name(s) Generic Names Lutalyse Rezulin Fat Loss Agents—Stimulants Trade Names 83 81 82 83 Adipex Albuterol Clenbuterol Phentermine hydrochloride Albuterol sulfate Clenbuterol hydrochloride 84 Ephedrine 85 86 87 HELIOS Meridia Over-the-counter Fat Loss Stack 88 Other over-the-counter Fat Loss Supplement 89 90 Yohimbine Zaditen Ephedrine hydrochloride or Ephedrine sulfate Clenbuterol hydrochloride + yohimbine Sibutramine HCL Caffeine + ephedrine (Mau Huang) + aspirin Caffeine, ephedrine, yohimbine, hoodia, chromium picolinate, guarana, bitter orange, synphrine Yohimibine hydrochloride Ketotifen Adipex-P Proventil, Ventolil Spirpent, Broncoterol, Clenasma, Monores, Novegam, Oxyflux, Contraspasmin, Ventolase Hyper Thermal Lipolytic System Meridia ECA Stack, Zaditor Fat Loss Agents—Thyroid Code # 91 92 93 Primary Trade/Street Name(s) Cytomel “T-3” Synthroid “T-4” Triacana Generic Names Liothyronine sodium Levothyroxine sodium Tiatricol Code # 94 Primary Trade/Street Name(s) Dinitrophenol, “DNP”, “Nitro” Generic Names 2,4-Dinitrophenol 95 96 97 Capoten Parlodel Thiomucase Captopril Bromocriptine mesylate Mucopolysaccharidase Trade Names Cytomel Synthroid Triacana Fat Loss Agents—Other Trade Names Dinitriso, Nitromet, Dinitrenal, Alpha Dintrophenol Capoten Parlodel Thiomucase Endurance & Erythropoietic Agents Code # 98 99 100 Primary Trade/Street Name(s) Aranesp Epogen, “EPO” Provigil Generic Names Darbapoetin alfa Epoietin alfa Modafinil Trade Names Erythropoietin, r-HuEPO Modiodal, Vigil, Alertec, Modasomil Other Anabolic 101 Other 84 Ancillary Agents—Anti Estrogens Code # 1 2 3 4 5 6 7 8 9 10 11 12 Primary Trade/Street Name(s) Arimidex Aromasin Clomid Cyclofenil Cytadren Evista Fareston Faslodex Femara Lentaron Nolvadex, “Nolva” Teslac Generic Names Anastrozole Exemestane Clomiphene citrate Cyclofenil Aminoglutethimide Raloxifene Tormifene citrate Fluvestrant Letrozole Formestane Tamoxifen citrate Testolactone Trade Names Arimidex, Liquidex Aromasin Clomid Cyclofenil Cytadren Evista Fareston Faslodex Femara Lenatron Nolvadex Teslac Ancillary Agents—Diuretics 13 14 15 16 17 18 Aldactazide Aldactone Dyazide Hydrodiuril Lasix Lasilactone 19 20 21 22 23 Ativan Klonopin Valium Xanax Other Benzodiazepine 24 25 26 27 28 29 30 31 Aldactone Aldactizide Anandron Cyproterone Acetate D-Trytophan- 6 Fentamide Luteinizing Hormone Nizoral Spironolactone + hydrochlorthiazide Spironolactone Triamterene + hydrochlorothiazide Hydrochlorthiazide Furosemide Spironolactone + furosemide Adlactazide Aldactone Dyazide Hydrodiuril Lasix Lasilactone Ancillary Agents—Anti Anxiety Lorazepam Clonazepam Diazepam Alprazolam Ativan, Temesta Klonopin, Rivotril Valium Xanax, Niravam Ancillary Agents—Androgen Blocker 85 32 33 34 Provera Spironolactone Other Androgen Blocker Ancillary Agents—Anti Hypertensive 35 36 Prescription anti-hypertensive Over-the-counter anti-hypertensive Ancillary Agents—Anti Depression 37 38 Prescription anti-depressant Over-the-counter anti-depressant Prozac, Paxil, Zoloft St. John’s Wart, etc. Ancillary Agents—Sleeping Pills 39 40 Prescription sleeping pills Over-the-counter sleeping pills Ambien, Sunesta, etc. Melatonin, Unisom, etc. 41 42 43 44 Prescription pain killer Over-the-counter pain killer Prescription anti-inflammatory Over-the-counter anti-inflammatory Ancillary Agents—Pain Killer/Anti-inflammatory Nubian, oxycodon, Vicodine Aspirin, Tylenol, etc. Celebrex, Vioxx, etc. Ibprofen, Aleve, etc. Ancillary Agents—Hair Loss Prevention 45 46 Prescription hair loss Over-the-counter hair loss 47 Human Chorionic Gonadatropin Propecia Rogaine Ancillary Agent—Hormone Stimulator Ancillary Agents—Anti-impotence/Performance Enhancer 48 49 Prescription anti-impotence/performance enhancer Over-the-counter antiimpotence/performance enhancer Viagra, Cialis Ancillary Agents—Other 50 51 Other Prescription Ancillary Other Over-the-counter Ancillary 86 On‐CycleSideEffects Physical Side Effects? Water retention? Headaches? Nosebleeds? Tremors or shakiness? Excessive Sweating? Can’t stop moving or excessive energy? Stomach Pain? Diarrhea? Joint pain? Digestive trouble such as indigestion or excessive gas? Fatigue easily? Nausea or vomiting? Muscle cramps or spasms? Flu-like symptoms? Dehydration? Heart palpitations? Heart skips a beat? Heat intolerance? Night sweats? Trouble falling or staying asleep? Sleeping too much? 87 On‐CycleSideEffects Painful prostate? Muscle or Tendon tear? Sexual Side Effects? Excessive Sex Drive? Difficulty getting an erection or becoming aroused? Testicular Shrinkage or Clitoral Enlargement? Decrease in Sex Drive? Difficulty having an orgasm? Infertility or Amenhorrea? Administration Related Side Effects? Abscess at injection site Allergic or bad reaction to injection or substance consumed Scarring from injections Extreme pain or swelling at injection site Medical Consequences? Increased Blood Pressure? Increased liver function test? Polycystic Ovarian Syndrome? Elevated Cholesterol? Enlarged Prostate? Heart condition? Affective or Mood Related Side Effects? 88 On‐CycleSideEffects Increased Anxiety, Worry, or Fear? Increased Depression? Increased number of Mood Swings? Panic attacks? Increased Irritability? Lower frustration tolerance? Increased Aggression? Cognitive Side Effects? Difficulty Concentrating or Focusing? Thoughts are racing or moving too quickly? Difficulty making decisions? Difficulty remembering things? Unwanted Changes in Appearance? Acne? Intestinal growth? Bone growth? Increased hair growth (body or face)? Hair loss or baldness? Flushed face? Gynecomastia or “gyno”? Loss of breast tissue? Change in facial features? 89 Post‐CycleSideEffects Affective or Mood Related Side Effects? Increased Anxiety, Worry, or Fear? Increased Depression? Increased number of Mood Swings? Panic attacks? Increased Irritability? Lower frustration tolerance? Increased Aggression? Physical Side Effects? Trouble falling or staying asleep? Sleeping too much? Difficulty Concentrating or Focusing? Decrease in Sex Drive? Suicidal Thoughts