LOUISVILLE
UNIVERSITY OF
LOUISVILLE
Louisville, KY 40292
TEL: (502) 852-6798
FAX: (502) 852-8149
Web: www.louisville.edu/chemistry
Email: chemistry@louisville.edu
Department of Chemistry
George R. Pack, Chair.
Craig C. Grapperhaus, Vice-Chair.
Degrees Offered: B.A, B.S, M.S, Ph.D.
Fields of Specialization: Analytical, Inorganic, Organic, Physical Chemistry, Chemical Physics and
Biochemistry.
Interdisciplinary Program: Chemical Physics (Department of Physics) and Chemistry (Department of
Chemistry, Western Kentucky University).
BALDWIN, RICHARD P. (b.1950) Professor. B.A,
1970, Thomas More College; Ph.D, 1976, Purdue University. Analytical Chemistry. Electroanalytical chemistry, analytical applications of chemically modified electrodes, liquid chromatography and capillary electrophoresis with electrochemical detection, microfabricated instrumentation. TEL: (502) 852-5892 FAX: (502) 8528149
Web: louisville.edu/a-s/chemistry/faculty/rpb.htm
Email: rick.baldwin@louisville.edu
Susan Carroll, Mark M. Crain, John F. Naber, Robert S.
Keynton, Kevin M. Walsh and Richard P. Baldwin, Room
temperature UV adhesive bonding of CE devices, Lab on a
Chip, 8, 1564-1569 (2008).
Lukasz Sztaberek, Michael D. Martin, Richard P. Baldwin
and Thomas Roussel, Jr, Microfabrication techniques for the
development of a miniaturized Hg-free ASV sensor for
drinking water, Prepr. Ext. Abstr. ACS Natl. Meet., Am.
Chem. Soc., Div. Environ. Chem, 48, 1059 (2008).
D. B. Franco, Advances in electrochemical detection for
lab-on-a-chip systems. (D)
BUCHANAN, ROBERT M. (b.1951) Professor. B.A,
1973, Western Maryland College; M.S, 1975, West Virginia University; Ph.D, 1980, University of Colorado.
Postdoctoral Associate, 1980-1981, University of Colorado; Postdoctoral Associate, 1981-1982, M. I. T. Inorganic Chemistry. Synthesis, structure, and magnetic
properties of inorganic and bioinorganic compounds; active site models of mu.-oxo iron proteins; polynuclear
manganese complexes as models of PSII and pseudocatalase proteins; mixed valence complexes; C-H bond
function; conducting polymers; phthalocyanine complexes, electrocatalysis. TEL: (502) 852-6580 FAX:
(502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/rmb.htm
Email: bob.buchanan@louisville.edu
Sara E. Edison, Sean D. Conklin, Necati Kaval, Lionel E.
Cheruzel, Jeanette A. Krause, Carl J. Seliskar, William R.
Heineman, Robert M. Buchanan and Michael J. Baldwin,
Spectroscopic characterization of a Ni-organic radical intermediate in the aerobic oxidation of methanol catalyzed by a
Ni(II)(polyoximate) complex, Inorg. Chim. Acta, 361, 947955 (2008).
BURNS, CHRISTOPHER T. (b.1972) Assistant Professor. B.S, 1996, University of Idaho; M.S, 1998, University of Idaho; Ph.D, 2005, University of Chicago.
Postdoctoral Research Associate, 2005-2008, Argonne
National Laboratory. Organic Chemistry; Organometallic Chemistry. Synthetic and mechanistic organometallic
chemistry; ligand oriented catalyst design, late transition
metal and single-site homogenous olefin polymerization
catalysis, polymerization of functionalized olefins, polymer chemistry, small molecule activation, catalytic C-X
(X = H, C, B, Si) bond formation, stereoselective synthesis and catalysis, periodic mesoporous silica for catalysis, heterogenous catalysis. TEL: (502) 852-5977 FAX:
(502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/ctb.htm
Email: ctburn02@louisville.edu
F. Wu, S. R. Foley, C. T. Burns and R. F. Jordan, Acrylonitrile insertion reactions of cationic palladium alkyl complexes, J. Am. Chem. Soc, 127, 1841-1853 (2005).
L. E. Iton, A. J. Crisci, V. Vajdova, P. D. Laible, C. T.
Burns and M. A. Firestone, Synthesis and characterization of
mesostructured silicas and gold frameworks as active matrices for biomolecule encapsulation, Advances in Science and
Technology, 51, 30-37 (2006).
Christopher T. Burns and Richard F. Jordan, Ethylene Dimerization by Cationic Palladium(II) Alkyl Complexes that
Contain Bis(heterocycle)methane Ligands, Organometallics,
26, 6726-6736 (2007).
Christopher T. Burns and Richard F. Jordan, Ethylene
polymerization by sterically crowded palladium(II) complexes that contain bis(heterocycle)methane ligands, Organometallics, 26, 6737-6749 (2007).
Matthew P. Conley, Christopher T. Burns and Richard F.
Jordan, Mechanism of Ethylene Oligomerization by a Cationic Palladium(II) Alkyl Complex that Contains a (3,5-Me2pyrazolyl)2CHSi(p-tolyl)3 Ligand, Organometallics, 26,
6750-6759 (2007).
C. T. Burns, S. W. Lee, S. Seifert and M. A. Firestone,
Thiophene-based ionic liquids: Synthesis, physical properties, self-assembly and oxidative polymerization, Polymers
for Advanced Technologies, 19, 1369-1382 (2008).
C. T. Burns, S. Y. Choi, M. L. Dietz and M. A. Firestone,
Acidichromic spiropyran-functionalized mesoporous silica:
Towards stimuli-responsive metal ion separations media, Separation Science and Technology, 43, 2506-2519 (2008).
J. K. Nelson, C. T. Burns, M. P. Smith, B. Twamley and N.
R. Natale, Synthetic utility of epoxides for chiral functionalization of isoxazoles, Tetrahedron Lett, 49, 3078-3082
(2008).
Jared K. Nelson, Christopher T. Burns, Miles P. Smith,
Brendan Twamley and N. R. Natale, Synthetic utility of epoxides for chiral functionalization of isoxazoles, Tetrahedron
Lett, 49, 3078-3082 (2008).
DUPRE, DONALD B. (b.1942) Professor. B.A, 1964,
Rice University; M.A, 1966, Princeton University; Ph.D,
1968, Princeton University. Postdoctoral Fellowship,
1968-1969, North American Rockwell Corp. Physical
Chemistry. Theory of molecular conformational analysis
and stereoelectronic effects. TEL: (502) 852-5976 FAX:
(502) 852-8149
Web: www.louisville.edu/a-s/chemistry/faculty/dbd/prf.
htm
Email: d.dupre@louisville.edu
Andres Puppato, Donald B. DuPre, Neal Stolowich and M.
Cecilia Yappert, Effect of temperature and pH on 31P nuclear
magnetic resonances of phospholipids in cholate micelles,
Chem. Phys. Lipids, 150, 176-185 (2007).
Lucius E. Johnson and Donald B. DuPre, Mechanism of
the Electronic Stabilization of the 3MR and Divalent Carbon
of Bis(diisopropylamino)cyclopropenylidene, J. Phys. Chem.
A, 111, 11066-11073 (2007).
Donald B. DuPre and John L. Wong, Thiamin Deprotonation Mechanism. Carbanion Development Stabilized by the
LUMOs of Thiazolium and Pyrimidylimine Working in Tandem and Release Governed by a H-Bond Switch, J. Phys.
Chem. A, 111, 2172-2181 (2007).
Lucius E. Johnson and Donald B. DuPre, Topological and
Orbital-Based Mechanisms of the Electronic Stabilization of
Bis(Diisopropylamino)Cyclopropenylidene, J. Phys. Chem.
A, 112, 7448-7454 (2008).
FAN, TERESA WHEI-MEI (b.1955) Professor. B.S,
1977, National Taiwan University; M.S, 1979, University of Hawaii at Manoa; Ph.D, 1983, University of California, Davis. Postdoctoral Affiliate, 1984-1986, Stanford University; Visiting Postdoctoral, 1986, University
of California, Davis. Biochemistry. Stress metabolism
and contaminant biotransformation by primary producers
and aquatic invertebrates in response to salinity, anaerobiosis and anthropogenic pollution. TEL: (502) 852-6448
FAX: (502) 852-6448
Web: louisville.edu/a-s/chemistry/faculty/twf.htm
Email: teresa.fan@louisville.edu
J. E. Podrabsky, J. E. Lopez, T.-W. Fan, R. Higashi and G.
N. Somero, Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: Insights from a metabolomics analysis, Journal of Experiemental Biology, 210,
2253-2266 (2007).
A. N. Lane and T. W.-M Fan, Quantification and identification of isotopomer distributions of metabolites in crude cell
extracts using 1H TOCSY, Metabolomics, 3, 79-86 (2007).
L. W. Sumner, A. Amberg, D. Barrett, R. Beger, M. H.
Beale, C. Daykin, T.-W. Fan, O. Fiehn, R. Goodacre, J. L.
Griffin, R. Higashi, J. Kopka, J. C. Lindon, A. N. Lane, P.
Marriott, A. W. Nicholls, M. D. Reily and M. Viant, Proposed minimum reporting standards for chemical analysis,
Metabolomics Journal, 3, 211-221 (2007).
S. Sansone, B. Nikolau, B. van Ommen, B. Kristal, C. Taylor, D. Robertson, J. Lindon, J. Griffin, L. Sumner, M. van
der Werf, N. Hardy, N. Morrison, P. Mendes, R. KaddurahDaouk, R. Goodacre, T. Fan and O. Fiehn, The metabolomics
standards initiative (MSI), Nature Biotechnology, 25, 2-4
(2007).
T. Fan, M. Kucia, K. Jankowski, R. Higashi, J. Ratajczak,
M. Ratajczak and A. Lane, Rhabdomyosarcoma cells show
an energy producing anabolic metabolic phenotype compared
with primary myocytes, Mol. Cancer, 7, 79 (2008).
S. C. McNeely, A. C. Belshoff, B. T. Frazier, T. W.-M.
Fan, M. J. McCabe Jr., A. Pinhas and J. C. States, Sensitivity
to sodium arsenite depends upon susceptibility to arsenite-induced mitotic arrest, Toxicology and Applied Pharmacology,
228, 252-261 (2008).
1
GRAPPERHAUS, CRAIG A. (b.1972) Associate
Professor. Ph.D, 1998, Texas A&M University. Alexander von Humboldt Post-doctoral Fellow, 1998-2000,
Max-Planck Institute fur Strahlenchemie. Inorganic
Chemistry. Metal-thiolates; ligand-based reactivity; inorganic synthesis. TEL: (502) 852-5932 FAX: (502) 8528149
Web: louisville.edu/a-s/chemistry/faculty/cag.htm
Email: grapperhaus@louisville.edu
Craig A. Grapperhaus, Martin G. O’Toole and Mark S.
Mashuta,
{3,3’-[Ethane-1,2-diylbis(methylimino)]bis(propane-1-thiolato)}nickel(II), Acta Crystallogr., Sect. E: Struct.
Rep. Online, E63, m2281 (2007).
Craig A. Grapperhaus, Pawel M. Kozlowski, Devesh Kumar, Holly N. Frye, Kiran B. Venna and Selma Poturovic,
Singlet diradical character of an oxidized ruthenium trithiolate: electronic structure and reactivity, Angew. Chem., Int.
Ed, 46, 4085-4088 (2007).
Kayla N. Green, Scott M. Brothers, Roxanne M. Jenkins,
Cody E. Carson, Craig A. Grapperhaus and Marcetta Y. Darensbourg, An Experimental and Computational Study of Sulfur-Modified Nucleophilicity in a Dianionic NiN2S2 Complex, Inorg. Chem. (Washington, DC, U. S.), 46, 7536-7544
(2007).
Craig A. Grapperhaus, Kiran B. Venna and Mark S. Mashuta, Carbon-Sulfur Bond Formation via Alkene Addition to
an Oxidized Ruthenium Thiolate, Inorg. Chem. (Washington,
DC, U. S.), 46, 8044-8050 (2007).
Martin G. O’Toole, Majda Kreso, Pawel M. Kozlowski,
Mark S. Mashuta and Craig A. Grapperhaus, Spin-state-dependent oxygen sensitivity of iron dithiolates: Sulfur oxygenation or disulfide formation, Journal of Biological Inorganic
Chemistry, 13, 1219-1230 (2008).
Gregory J. Grant, Maikel E. Botros, Jared S. Hassler, Daron E. Janzen, Craig A. Grapperhaus, Martin G. O’Toole and
Donald G. VanDerveer, Hg(II) and Cd(II) complexes with
mixed donor macrocyclic thioethers: The oxophobicity of
mercury(II), Polyhedron, 27, 3097-3104 (2008).
K. Ouch, Redox-regulated ethylene binding to a rheniumthiolate complex. (M)
M. G. O’Toole, Reactivity of an iron- and nickel-dithiolate
model complexes of nitrile hydratase. (D)
HAMMOND, GERALD B. (b.1952) Professor. B.S,
1975, Pontificia Universidad Catolica del Peru; M.S,
1979, University of British Columbia; Ph.D, 1987, University of Iowa. Postdoctoral Research Fellow, 19851987, University of Iowa. Organic Chemistry. Selective
fluorine incorporation in organic compounds, appplications to biological properties; systematic and targeted
study of Peruvian bioactive plants. TEL: (502) 852-5998
FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/gbh.htm
Email: gb.hammond@louisville.edu
Jesse M. Jacobsen, Satoru Arimitsu, Gerald B. Hammond
and Mark S. Mashuta, 3-Fluoro-2,4,5-triphenylfuran, Acta
Crystallogr., Sect. E: Struct. Rep. Online, E63, o4337,
So4337/1-So4337/8 (2007).
Moustapha Bah, Lilia Cherigo, Alexandre T. Cardoso
Taketa, Mabel Fragoso-Serrano, Gerald B. Hammond and
Rogelio Pereda-Miranda, Intrapilosins I-VII, pentasaccharides from the seeds of Ipomoea intrapilosa, J. Nat.
Prod, 70, 1153-1157 (2007).
Satoru Arimitsu and Gerald B. Hammond, Selective Synthesis of Fluorinated Furan Derivatives via AgNO3-Catalyzed Activation of an Electronically Deficient Triple Bond,
J. Org. Chem, 72, 8559-8561 (2007).
Santos Fustero, Begona Fernandez, Paula Bello, Carlos
Del Pozo, Satoru Arimitsu and Gerald B. Hammond, Intramolecular Hydroamination of Difluoropropargyl Amides:
Regioselective Synthesis of Fluorinated ␤- and ␥-Lactams,
Org. Lett, 9, 4251-4253 (2007).
Satoru Arimitsu, Jesse M. Jacobsen and Gerald B. Hammond, gem-Difluoropropargylation of aldehydes using cat.
In/Zn in aqueous media, Tetrahedron Lett, 48, 1625-1627
(2007).
Bo Xu and Gerald B. Hammond, Thermodynamically favored aldol reaction of propargyl or allenyl esters: regioselective synthesis of carbinol allenoates, Angew. Chem., Int.
Ed, 47, 689-692 (2008).
Syed R. Hussaini and Gerald B. Hammond, Eschenmoser
coupling reaction of selenoamides. Synthesis of enamino ester, Arkivoc, 129-136 (2008).
Bo Xu and Gerald B. Hammond, On the nature of orgnoindiuim intermediates: The formation of readily isolable difluoropropargylindium reagents and their regioselectivity
towards electrophilic substitutions, Chemistry-A European
Journal, 14, 10029-10035 (2008).
Bo Xu and Gerald B. Hammond, Recent advances of CF2metal reagents in organic synthesis, Chimica Oggi-Chemistry
Today, 26, 20-21 (2008).
Jose C. Aponte, Manuela Verastegui, Edith Malaga, Mirko
Zimic, Miguel Quiliano, Abraham J. Vaisberg, Robert H.
Gilman and Gerald B. Hammond, Synthesis, Cytotoxicity,
and Anti-Trypanosoma cruzi Activity of New Chalcones, J.
Med. Chem, 51, 6230-6234 (2008).
Jose C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz
Caviedes, Walter H. Lewis, Gerardo Lamas, Cesar Sarasara,
2
LOUISVILLE
Robert H. Gilman and Gerald B. Hammond, Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants, J. Nat. Prod, 71, 102-105 (2008).
Satoru Arimitsu, Begona Fernandez, Carlos del Pozo, Santos Fustero and Gerald B. Hammond, Concise Preparation of
2,2-Difluorohomopropargyl Carbonyl Derivatives. Application to the Synthesis of 4,4-Difluoroisoquinolinone Congeners, J. Org. Chem, 73, 2656-2661 (2008).
Satoru Arimitsu, Jesse M. Jacobsen and Gerald B. Hammond, Synthesis of 2,4,5-Trisubstituted 3-Fluorofurans via
Sequential Iodocyclization and Cross-Coupling of gem-Difluorohomopropargyl Alcohols, J. Org. Chem, 73, 2886-2889
(2008).
Satoru Arimitsu, Rebecca L. Bottom and Gerald B. Hammond, Selective enhancement effects of silver salts on the
transition metal-catalyzed synthesis of gem-difluorinated heterocyclics using 2, 2-difluorohomopropargyl amides, Journal
of Fluorine Chemistry, 129, 1047-1051 (2008).
Weibo Wang, Bo Xu and Gerald B. Hammond, Synthesis
of Functionalized ␣,␣-Disubstituted ␤-Alkynyl Esters from
Allenoates through an Alkynylenolate Intermediate, Org.
Lett, 10, 3713-3716 (2008).
Le-Ping Liu, Bo Xu and Gerald B. Hammond, Michael
Addition of Allenoates to Electron-Deficient Olefins: Facile
Synthesis of 2-Alkynyl-Substituted Glutaric Acid Derivatives, Org. Lett, 10, 3887-3890 (2008).
Han Yang, Bo Xu and Gerald B. Hammond, Highly regioselective fluorination and iodination of alkynyl enolates,
Organic Letters, 10, 5589-5591 (2008).
Jose C. Aponte, Yannick Estevez, Rober H. Gilman, Walter H. Lewis, Rosario Rojas, Michel Sauvain, Abraham J.
Vaisberg and Gerald B. Hammond, Anti-infective and cytotoxic compounds present in Blepharodon nitidum, Planta
Medica, 74, 407-410 (2008).
H. Yang, Highly regioselective fluorination and iodination
of alkylyl enolates and phytochemical analysis of Ambrosia
Peruviana. (M)
B. Xu, New difluoromethylene templates and discovery of
an alkynylogous aldol reaction through an allene-propargyl
interconverstion. (D)
S. Arimitsu, Transformative synthesis of fluorinated heterocyclics using a difluorohomoproprgylic template. Synthetic applications and mechanistic investigations. (D)
HIGASHI, RICHARD M. (b.1954) Associate Professor. B.S, 1977, University of Hawaii; Ph.D, 1987, University of California, Davis. Postdoctoral Research
Chemist, 1987-1989, University of California, Bodega
Marine Laboratory. Analytical Chemistry. Development
of mass spectrometry techniques for biochemical and
biomedical research. TEL: (502) 852-7496 FAX: (502)
852-8149
Web: louisville.edu/a-s/chemistry/faculty/rmh.htm
Email: rick.higashi@louisville.edu
Teresa W.-M. Fan, Richard M. Higashi and Andrew N.
Lane, Integrating metabolomics and transcriptomics for probing Se anticancer mechanisms. [Erratum to document cited in
CA146:197468], Drug Metab. Rev, 39, 249 (2007).
Andrew N. Lane, Teresa W.-M. Fan and Richard M. Higashi, Stable isotope-assisted metabolomics in cancer research,
IUBMB Life, 60, 124-129 (2008).
Andrew N. Lane, Teresa W.-M. Fan and Richard M. Higashi, Isotopomer-based metabolomic analysis by NMR and
mass spectrometry, Methods Cell Biol, 84, 541-588 (2008).
Teresa W.-M. Fan, Majda Kucia, Kacper Jankowski, Richard M. Higashi, Janina Ratajczak, Marius Z. Ratajczak and
Andrew N. Lane, Rhabdomyosarcoma cells show an energy
producing anabolic metabolic phenotype compared with primary myocytes, Molecular Cancer, 7 (2008).
KOZLOWSKI, PAWEL M. (b.1962) Associate Professor. Ph.D, 1992, University of Arizona. Postdoctoral
Research Associate, 1994-1996, University of Arkansas;
Postdoctoral Research Associate, 1996-1999, Princeton
University. Physical Chemistry. Modeling structure and
spectroscopic properties of biological molecules. TEL:
(502) 852-6609 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/pmk.htm
Email: pawel@louisville.edu
Craig A. Grapperhaus, Pawel M. Kozlowski, Devesh Kumar, Holly N. Frye, Kiran B. Venna and Selma Poturovic,
Singlet diradical character of an oxidized ruthenium trithiolate: electronic structure and reactivity, Angew. Chem., Int.
Ed, 46, 4085-4088 (2007).
Pawel M. Kozlowski, Takashi Kamachi, Tetsuo Toraya
and Kazunari Yoshizawa, Does Cob(II)alamin act as a conductor in coenzyme B12 dependent mutases?, Angew. Chem.,
Int. Ed, 46, 980-983 (2007).
Pawel M. Kozlowski, Yoshihito Shiota, Satomi Gomita,
Hidetake Seino, Yasushi Mizobe and Kazunari Yoshizawa,
DFT analysis of cubane-type FeIr3S4 clusters. Dinitrogen
binding and activation at the tetrahedral Fe site, Bull. Chem.
Soc. Jpn, 80, 2323-2328 (2007).
Kazunari Yoshizawa, Tomonori Nakayama, Takashi Kamachi and Pawel M. Kozlowski, Vibronic Interaction in
Metalloporphyrin ␲-Anion Radicals, J. Phys. Chem. A, 111,
852-857 (2007).
Maria Jaworska, Piotr Lodowski, Tadeusz Andruniow and
Pawel M. Kozlowski, Photolysis of Methylcobalamin: Identification of the Relevant Excited States Involved in Co-C
Bond Scission, J. Phys. Chem. B, 111, 2419-2422 (2007).
Carme Rovira and Pawel M. Kozlowski, First Principles
Study of Coenzyme B12. Crystal Packing Forces Effect on
Axial Bond Lengths, J. Phys. Chem. B, 111, 3251-3257
(2007).
Pawel M. Kozlowski, Jadwiga Kuta and Wlodzimierz Galezowski, Reductive Cleavage Mechanism of Methylcobalamin: Elementary Steps of Co-C Bond Breaking, J. Phys.
Chem. B, 111, 7638-7645 (2007).
Tadeusz Andruniow, Maria Jaworska, Piotr Lodowski,
Marek Z. Zgierski, Renata Dreos, Lucio Randaccio and Pawel M. Kozlowski, Time-dependent density functional theory
study of cobalt corrinoids: Electronically excited states of
methylcobalamin, J. Chem. Phys, 129, 085101/1-085101/14
(2008).
Pawel M. Kozlowski, Jason R. Bingham and Andrzej A.
Jarzecki, Theoretical Analysis of Core Size Effect in
Metalloporphyrins, J. Phys. Chem. A, 112, 12781-12788
(2008).
Wlodzimierz Galezowski, Jadwiga Kuta and Pawel M.
Kozlowski, DFT Study of Co-C Bond Cleavage in the Neutral and One-Electron-Reduced Alkyl-Cobalt(III) Phthalocyanines, J. Phys. Chem. B, 112, 3177-3183 (2008).
Martin G. O’Toole, Majda Kreso, Pawel M. Kozlowski,
Mark S. Mashuta and Craig A. Grapperhaus, Spin-state-dependent oxygen sensitivity of iron dithiolates: Sulfur oxygenation or disulfide formation, Journal of Biological Inorganic
Chemistry, 13, 1219-1230 (2008).
J. Kuta, DFT analysis of structural and electronic properties of cobalt corrinoids. (D)
LAMM, GENE (b.1949) Assistant Professor. B.S,
1971, Mississippi State University; M.S, 1972, Western
Illinois University; Ph.D, 1980, Indiana University. Postdoctoral Research, 1980, Max-Planck-Institut fur biophysikalische Chemie; Postdoctoral Research, 19801982, Technische Universitat Munchen; Guest Worker,
1982-1983, National Institutes of Health; Senior Staff
Fellow, 1983-1987, National Institutes of Health. Biophysics/Biophysical Chemistry. Theoretical and computational biophysical chemistry and chemical physics.
Thermodynamics and statistical mechanics of biomolecules. TEL: (502) 852-2971 FAX: (502) 852-8149
Web: www.louisville.edu/a-s/chemistry/resassoc/eel/prf.
htm
Email: glamm@louisville.edu
No publication information submitted for this edition.
LANE, ANDREW N. (b.1953) Professor. B.Sc, 1975,
University College London; Ph.D, 1979, University College London. Postdoctoral Research, 1979-1983, University of Basel; EMBO Fellow, 1983-1986, Stanford. Biophysics/Biophysical Chemistry. Analysis of enzyme
structure and mechanisms by electronic spectroscopy
(circular dichroism, fluorescence and uv-vis), solution
scattering methods (dynamic light scattering, small angle
scattering), stopped-flow reaction kinetics, thermodynamics and hydrodynamics. Protein expression and purification and stable isotope labelling. Use of 2D and 3D
heteronuclear NMR for the determination of structure,
dynamics and interactions of nucleic acids and proteins
in solution. TEL: (502) 852-3067 FAX: (502) 852-3067
Web: biochemistry.louisville.edu/faculty/joint.php?id=
61
Email: anlane01@gwise.louisville.edu
Teresa W.-M. Fan, Richard M. Higashi and Andrew N.
Lane, Integrating metabolomics and transcriptomics for probing Se anticancer mechanisms. [Erratum to document cited in
CA146:197468], Drug Metab. Rev, 39, 249 (2007).
Lloyd W. Sumner, Alexander Amberg, Dave Barrett, Michael H. Beale, Richard Beger, Clare A. Daykin, Teresa W.M. Fan, Oliver Fiehn, Royston Goodacre, Julian L. Griffin,
Thomas Hankemeier, Nigel Hardy, James Harnly, Richard
Higashi, Joachim Kopka, Andrew N. Lane, John C. Lindon,
Philip Marriott, Andrew W. Nicholls, Michael D. Reily, John
J. Thaden and Mark R. Viant, Proposed minimum reporting
standards for chemical analysis. Chemical Analysis Working
Group (CAWG) Metabolomics Standards Initiative (MSI),
Metabolomics, 3, 211-221 (2007).
Andrew N. Lane and Teresa W.-M. Fan, Quantification
and identification of isotopomer distributions of metabolites
in crude cell extracts using 1H TOCSY, Metabolomics, 3, 7986 (2007).
Sucheta Telang, Andrew N. Lane, Kristin K. Nelson, Sengodagounder Arumugam and Jason Chesney, The oncoprotein H-RasV12 increases mitochondrial metabolism, Mol.
Cancer, 6, No pp. given (2007).
Metin Kurtoglu, Ningguo Gao, Jie Shang, Johnathan C.
Maher, Mark A. Lehrman, Medhi Wangpaichitr, Niramol Savaraj, Andrew N. Lane and Theodore J. Lampidis, Under
normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering
with N-linked glycosylation, Mol. Cancer Ther, 6, 30493058 (2007).
Lynn Deleeuw, Anna V. Tchernatynskaia and Andrew N.
Lane, Thermodynamics and Specificity of the Mbp1-DNA
Interaction, Biochemistry, 47, 6378-6385 (2008).
Joshua Marshall Thornburg, Kristin K. Nelson, Brian F.
Clem, Andrew N. Lane, Sengodagounder Arumugam, Allan
Simmons, John W. Eaton, Sucheta Telang and Jason Chesney, Targeting aspartate aminotransferase in breast cancer,
Breast Cancer Research, 10 (2008).
Afaf H. El-Sagheer, Ravindra Kumar, Stuart Findlow,
Joern M. Werner, Andrew N. Lane and Tom Brown, A very
stable cyclic DNA miniduplex with just two base pairs,
Chembiochem, 9, 50-52 (2008).
Andrew N. Lane, Teresa W.-M. Fan and Richard M. Higashi, Stable isotope-assisted metabolomics in cancer research,
IUBMB Life, 60, 124-129 (2008).
Sengodagounder Arumugam, Robert D. Gray and Andrew
N. Lane, NMR structure note: Alkaline proteinase inhibitor
APR in from Pseudomonas aeruginosa, Journal of Biomolecular NMR, 40, 213-217 (2008).
Andrew N. Lane, Teresa W.-M. Fan and Richard M. Higashi, Isotopomer-based metabolomic analysis by NMR and
mass spectrometry, Methods Cell Biol, 84, 541-588 (2008).
Teresa W.-M. Fan, Magda Kucia, Kacper Jankowski,
Richard M. Higashi, Janina Ratajczak, Marius Z. Ratajczak
and Andrew N. Lane, Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with
primary myocytes, Molecular Cancer, 7 (2008).
Andrew N. Lane, J. Brad Chaires, Robert D. Gray and
John N. Trent, Stability and kinetics of G-quadruplex structures, Nucleic Acids Research, 36, 5482-5515 (2008).
Teresa W.-M. Fan and Andrew N. Lane, Structure-based
profiling of metabolites and isotopomers by NMR, Prog.
Nucl. Magn. Reson. Spectrosc, 52, 69-117 (2008).
LUZZIO, FREDERICK A. (b.1953) Professor. B.S,
1976, Vanderbilt University; M.S, 1979, Tufts University; Ph.D, 1982, Tufts University. Postdoctoral Fellowship, 1982-1985, Harvard University. Organic Chemistry. Synthetic methods, total synthesis and medicinal
chemistry. TEL: (502) 852-7323 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/fal.htm
Email: faluzz01@gwise.louisville.edu
Frederick A. Luzzio, Marek T. Wlodarczyk, Damien Y.
Duveau and Juan Chen, Preparation of ␤-phenylnitroethanes
having electron-donating aryl substitution, Tetrahedron Lett,
48, 6704-6708 (2007).
Frederick A. Luzzio and Juan Chen, Efficient Preparation
and Processing of the 4-Methoxybenzyl (PMB) Group for
Phenolic Protection Using Ultrasound, J. Org. Chem, 73,
5621-5624 (2008).
M. T. Wlodarczyk, Preparation of A) benzoheterocyclic aldehydes and B) 2-arylnitroethanes as useful intermediates in
organic synthesis. (M)
MAURER, MURIEL C. (b.1965) Professor. B.A,
1987, Goucher College; Ph.D, 1993, University of Virginia. NIH Postdoctoral Fellow, 1992-1995, Cornell University; Postdoctoral Associate/ Research Associate,
1995-1997, Cornell University. Biochemistry. Protein
structure-function relationships; enzyme-ligand interactions; blood coagulation; protein folding; kinetics; NMR;
MALDI-TOF mass spectrometry. TEL: (502) 852-7008
FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/mcm.htm
Email: muriel.maurer@louisville.edu
T. Michael Sabo, P. Bradley Brasher and Muriel C. Maurer, Perturbations in Factor XIII Resulting from Activation
and Inhibition Examined by Solution Based Methods and
Detected by MALDI-TOF MS, Biochemistry, 46, 1008910101 (2007).
Giulia Isetti and Muriel C. Maurer, Employing Mutants to
Study Thrombin Residues Responsible for Factor XIII Activation Peptide Recognition: A Kinetic Study, Biochemistry,
46, 2444-2452 (2007).
D. B. Cleary, Kinetic and NMR studies of blood coagulant
factor xiiia: A quest for its glutamine substrate consensus sequence. (D)
T. M. Sabo, Perturbations in protein dynamics associated
with ligand binding to the blood coagulation enzymes thrombin and factor XIII. (D)
MENDES, SERGIO B. (b.1959) Associate Professor.
B.S, 1982, University of Sao Paulo; M.S, 1991, UFRGS;
Ph.D, 1997, University of Arizona. Chemical Physics;
Surface Chemistry. TEL: (502) 852-0908 FAX: (502)
852-0742
Web: www.physics.louisville.edu/sbmendes/
Email: sbmend01@louisville.edu
Brooke M. Beam, R. Clayton Shallcross, Jinuk Jang, Neal
R. Armstrong and Sergio B. Mendes, Planar fiber-optic chips
for broadband spectroscopic interrogation of thin films, Appl.
Spectrosc, 61, 585-592 (2007).
Casey M. Kraning, Tara L. Benz, Kayla S. Bloome, Gregory C. Campanello, Victoria S. Fahrenbach, Sheetal A. Mistry,
Carrie Ann Hedge, Ken D. Clevenger, Keith M. Gligorich,
Todd A. Hopkins, Geoffrey C. Hoops, Sergio B. Mendes,
Huan-Cheng Chang and Meng-Chih Su, Determination of
Surface Coverage and Orientation of Reduced Cytochrome c
LOUISVILLE
on a Silica Surface with Polarized ATR Spectroscopy, J.
Phys. Chem. C, 111, 13062-13067 (2007).
Ismail Emre Araci, Sergio B. Mendes, Nasuhi Yurt, Seppo
Honkanen and N. Peyghambarian, Highly sensitive spectroscopic detection of hemeprotein submonolayer films by
channel integrated optical waveguide, Opt. Express, 15,
5595-5603 (2007).
Niranjani Kumaran, Carrie L. Donley, Sergio B. Mendes
and Neal R. Armstrong, Characterization of the Angular Orientation Distribution of Discotic Molecules in Thin-Film Assemblies: Combinations of Polarized Transmission and Reflection-Absorption Infrared Spectroscopies, J. Phys. Chem.
C, 112, 4971-4977 (2008).
MOSELEY, HUNTER N. B. (b.1969) Assistant Professor. B.A, 1992, Huntingdon College; Ph.D, 1998,
University of Alabama at Birmingham. Bioinformatics;
NMR Spectroscopy. Broad Interests: A) Development of
computational tools and bioinformatics analyses for biological and biophysical data. B) Development of applications in NMR, mass spectrometry, structural biology, and
molecular biology. Specific Interests: 1) Automated
Analysis Tools for Magic Angle Spinning Solid State
NMR Protein Resonance Data. 2) Combined Computational and Experimental Study of Metalloproteins. 3)
Computational Tools for Experimental Systems Biochemistry (Metabolomics). TEL: (502) 852-7598 FAX:
(502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/hnm.htm
Email: hnmose01@louisville.edu
Y. P. J. Huang, H. N. B. Moseley, M. C. Baran, C. Arrowsmith, R. Powers, R. Tejero, T. Szyperski and G. T. Montelione, An integrated platform for automated analysis of protein NMR structures, Nuclear Magnetic Resonance of Biological Macromolecules, Part C, 394, 111 (2005).
M. C. Barasn, H. N. B. Moseley, J. M. Aramini, M. J. Bayro, D. Monleon, J. Y. Locke and G. T. Montelione, SPINS: A
laboratory information management system for organizing
and archiving intermediate and final results from NMR protein structure determinations, Proteins-Structure Function
and Bioinformatics, 62, 843-851 (2006).
G. J. Kornhaber, D. Snyder, H. N. B. Moseley and G. T.
Montelione, Identification of zinc-ligated cysteine residues
based on C-13 alpha and C-13 beta chemical shift data, Journal of Biomolecular NMR, 34, 259-269 (2008).
MUELLER, EUGENE G. (b.1965) Professor. B.S,
1987, University of Illinois at Urbana-Champaign; Ph.D,
1992, Harvard University. Postdoctoral Fellow, 19921994, California Institute of Technology; Postdoctoral
Fellow, 1994-1995, M. I. T. Biochemistry. Enzymology,
tRNA modification, sulfur transfer, bioorganic mechanism. TEL: (502) 852-5811 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/egm.htm
Email: eugene.mueller@louisville.edu
C. Hoang, C. S. Hamilton, E. G. Mueller and A. R. FerreD’Amare, Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to
an RNA-sequestering peripheral protein domain, Protein Science, 14, 2201-2206 (2005).
Christopher S. Hamilton, Todd M. Greco, Caroline A.
Vizthum, Joy M. Ginter, Murray V. Johnston and Eugene G.
Mueller, Mechanistic investigations of the pseudouridine
synthase RluA using RNA containing 5-fluorouridine, Biochemistry, 45, 12029-12038 (2006).
Chapman M. Wright, Glenn D. Christman, Ann M. Snellinger, Murray V. Johnston and Eugene G. Mueller, Direct
evidence for enzyme persulfide and disulfide intermediates
during 4-thiouridine biosynthesis, Chemical Communications, 3104-3106 (2006).
Charmaine Hoang, Junjun Chen, Caroline A. Vizthum, Jason M. Kandel, Christopher S. Hamilton, Eugene G. Mueller
and Adrian R. Ferre-D’Amare, Crystal structure of pseudouridine synthase RluA: Indirect sequence readout through protein-induced RNA structure, Molecular Cell, 24, 535-545
(2006).
E. G. Mueller, Trafficking in persulfides: Delivering sulfur
in biosynthetic pathways, Nature Chemical Biology, 2, 185194 (2006).
NANTZ, MICHAEL H. (b.1958) Professor. B.S,
1981, Western Kentucky University; Ph.D, 1987, Purdue
University. Postdoctoral Research Associate, 1987-1989,
M. I. T. Organic Chemistry. Cationic lipids and polymers for gene delivery; peptide-based prodrugs of cancer
chemotherapeutics; applications of nanoparticle-peptide
conjugates. TEL: (502) 852-8069 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/mhn.htm
Email: mhnant01@louisville.edu
Layla Al-Nakkash, Mark F. Springsteel, Mark J. Kurth and
Michael H. Nantz, Activation of CFTR by UCCF-029 and
genistein, Bioorg. Med. Chem. Lett, 18, 3874-3877 (2008).
Layla Al-Nakkash, Mark F. Springsteel, Mark J. Kurth and
Michael H. Nantz, Activation of CFTR by UCCF-029 and
genistein, Bioorganic and Medicinal Chemistry Letters, 18,
3874-3877 (2008).
James G. Hecker, Gideon O. Berger, Keith A. Scarfo,
Shaomin Zou and Michael H. Nantz, A flexible method for
the conjugation of aminooxy ligands to preformed complexes
of nucleic acids and lipids, ChemMedChem, 3, 1356-1361
(2008).
Ellen S. Hauck, Shaomin Zou, Keith Scarfo, Michael H.
Nantz and James G. Hecker, Whole animal in vivo imaging
after transient, nonviral gene delivery to the rat central nervous system, Molecular Therapy, 16, 1857-1864 (2008).
Bhaskar Poola, Wonken Choung and Michael H. Nantz, A
mild, catalyst-free synthesis of 2-aminopyridines, Tetrahedron, 64, 10798-10801 (2008).
NOBLE, MARK E. (b.1954) Professor. B.S, 1976,
Eckerd College; Ph.D, 1982, Indiana University. Inorganic Chemistry. Synthesis, structural and reactivity
properties of metal-sulfur compounds of catalytic and
enzymatic interest; bioinorganic chemistry. TEL: (502)
852-7296 FAX: (502) 852-8149
Web: www.louisville.edu/a-s/chemistry/faculty/men/prf.
htm
Email: menoble@louisville.edu
No publication information submitted for this edition.
PACK, GEORGE R. (b.1946) Professor and Chairman. B.S, 1968, Providence College; Ph.D, 1973, SUNY
at Buffalo. NIH Fellowship, 1973-1974, University of
Rochester; NIH Fellowship, 1974-1975, New York University; NIH Fellowship, 1975-1978, Stanford University. Physical Chemistry. Theoretical biophysical chemistry; computer simulations of the electrostatic properties
and their contribution to the regulation of nucleic acid
structure and function. TEL: (502) 852-6798 FAX: (502)
852-8149
Web: louisville.edu/a-s/chemistry/faculty/grp.htm
Email: george.pack@louisville.edu
No publication information submitted for this edition.
J. A. Koehler, Characterization of imidazolium and carboxylate species: Stabilizing factors and proton transport capabilities. (M)
POWE, ALEETA (b.1965) Assistant Professor. B.S,
1990, University of South Alabama; Ph.D, 2002, American University. Analytical Chemistry. Our research investigates Hyaluronan in the mammalian vitreous humor.
We want to: 1) determine normal states of HA oligosaccharides in each section (anterior, middle, posterior, rear)
of the vitreous humor; 2) assess changes in the normal
states of HA in each section in three pathological processes: age, diabetic retinopathy and posterior vitreous
detachment; and 3) correlate any assessed changes in HA
in each vitreous section to the above vision-limiting ocular conditions. TEL: (502) 852-5969 FAX: (502) 8528149
Web: louisville.edu/a-s/chemistry/faculty/amp.htm
Email: ampowe09@louisville.edu
Cevdet Akbay, Nicole L. Gill and Aleeta Powe, Monomeric and polymeric anionic gemini surfactants and mixed surfactant systems in micellar electrokinetic chromatography:
Part I: Characterization and application as novel pseudostationary phases, Electroporesis, 26, 415-425 (2005).
Aleeta M. Powe and Isiah M. Warner, Cyclodextrins hostguest chemistry in analytical and environmental chemistry,
Current Analytical Chemistry, 3, 171-181 (2007).
RICH, CHRISTINE V. (b.1951) Assistant Professor.
B.S, 1992, University of Louisville; Ph.D, 1997, University of Louisville. Chemistry Education; Organic Chemistry. Our research explores models of job-embedded
professional development in science at the K-5 level. A
current grant teams STEM graduate students with K-5
teachers to support the delivery of inquiry-based instruction using NSF-developed curricular materials. One goal
of the project is to assess the efficacy of pairing elementary teachers with science professionals in the classroom
to improve pedagogical content knowledge and best
teaching practices aligned with state and national standards. TEL: (502) 852-7814 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/cvr.htm
Email: cvrich01@louisville.edu
No publication information submitted for this edition.
RICHARDSON, JOHN F. (b.1954) Professor. B.S,
1976, University of Western Ontario; Ph.D, 1981, University of Western Ontario. Research Associate, 19821983, University of Calgary. Inorganic Chemistry. The
application of X-ray crystallography and molecular
graphics to structure-function relationships and nonbonded contacts; homogenous catalysts; bonding environments in heavier non-metals, ceramics, oligosaccharides and pseudopeptides. TEL: (502) 852-7069 FAX:
(502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/jfr.htm
Email: john.richardson@louisville.edu
James Britten, Nigel G. R. Hearns, Kathryn E. Preuss, John
F. Richardson and Sofi Bin-Salamon, Mn(II) and Cu(II)
Complexes of a Dithiadiazolyl Radical Ligand: Monomer/
3
Dimer Equilibria in Solution, Inorg. Chem. (Washington,
DC, U. S.), 46, 3934-3945 (2007).
RYPKEMA, HEATHER A. (b.1974) Assistant Professor. A.B, 1997, Harvard University; A.M, 1999, Harvard University; Ph.D, 2001, Harvard University. Postdoctoral Research Associate, 2002-2004, Stanford University. Physical Chemistry. The primary focus of the
Rypkema lab is on the physical underpinnings of chemical reactivity. Projects include the use of curve-crossing
analysis to understand barrier height evolution, kinetic
studies of wavelength-dependent photochemical reactions in the solvent phase, and the characterization of
conical intersections with electronic structure calculations. In addition, we are developing new methodologies
for the application of chemical soil analysis to survey archaeology. TEL: (502) 852-1223 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/har.htm
Email: heather.rypkema@louisville.edu
Heather A. Rypkema, Wayne E. Lee, Michael L. Galaty
and Jonathan Haws, Rapid, in-stride soil phosphate measurement in archaeological survey: A new method tested in Loudoun County, Virginia, Journal of Archaeological Science,
34, 1859-1867 (2007).
L. DeNeve, Soil phosphate detection and archaeology: Instride phosphate detection and the elimination of arsenate interference to the malachite green method. (M)
TRENT, JOHN—See Biochemistry Section, University of Louisville, School of Medicine, Department of Biochemistry and Molecular Biology.
WITTEBORT, RICHARD J. (b.1948) Professor.
B.S, 1972, Ohio State University; Ph.D, 1978, Indiana
University. NIH Postdoctoral Fellowship, 1978-1980,
Francis Bitter National Magnet Laboratory and M. I. T.
Physical Chemistry. Studies of molecular structure; dynamics and magnetic interactions by using high resolution solid state nuclear magnetic resonance methods.
Systems of interest include lipid bilayers, perovskite layered complexes, transition metal complexes and proteins.
TEL: (502) 852-6613 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/rjw.htm
Email: rjwitt01@louisville.edu
No publication information submitted for this edition.
WONG, JOHN LUI (b.1940) Professor. B.S, 1962,
Cheng Kung University; Ph.D, 1966, University Of California, Berkeley. Organic Chemistry. Chemical carcinogenesis and biomarkers; monoclonal antibody development; metal speciation and toxicity. TEL: (502) 8526611 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/jlw.htm
Email: john.wong@louisville.edu
No publication information submitted for this edition.
YAPPERT, M. CECILIA (b.1955) Professor. B.S,
1978, Universidad Nacional del Litoral; Ph.D, 1985, Oregon State University. Ames Laboratory Postdoctoral
Fellow, 1985-1986, Iowa State University. Analytical
Chemistry. Laser fluorescence spectroscopy; optical fibers for remote sensing; biological systems; IR and
NMR spectroscopy; lipid-lipid and lipid-protein interactions; lipid composition; lens composition. TEL: (502)
852-7061 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/mcy.htm
Email: mcyappert@louisville.edu
Douglas Borchman, Gary N. Foulks, Marta C. Yappert and
Donghai V. Ho, Temperature-induced conformational
changes in human tear lipids hydrocarbon chains, Biopolymers, 87, 124-133 (2007).
Andres Puppato, Donald B. DuPre, Neal Stolowich and M.
Cecilia Yappert, Effect of temperature and pH on 31P nuclear
magnetic resonances of phospholipids in cholate micelles,
Chem. Phys. Lipids, 150, 176-185 (2007).
Douglas Borchman, Gary N. Foulks, Marta C. Yappert,
Daxin Tang and Donghai V. Ho, Spectroscopic evaluation of
human tear lipids, Chemistry and Physics of Lipids, 147, 87102 (2007).
Li Huang, Marta C. Yappert, James J. Miller and Douglas
Borchman, Thyroxine ameliorates oxidative stress by inducing lipid compositional changes in human lens epithelial
cells, Investigative Ophthalmology & Visual Science, 48,
3698-3704 (2007).
Rosendo Estrada, Neal Stolowich and M. Cecilia Yappert,
Influence of temperature on 31P NMR chemical shifts of
phospholipids and their metabolites. I. In chloroform-methanol-water, Anal. Biochem, 380, 41-50 (2008).
Li Huang, Marta C. Yappert, Marcia M. Jumblatt and
Douglas Borchman, Hyperoxia and thyroxine treatment and
the relationships between reactive oxygen species generation,
mitochondrial membrane potential, and cardiolipin in human
lens epithelial cell cultures, Current Eye Research, 33, 575586 (2008).
4
LOUISVILLE
A. J. Puppato, Analytical and biophysical studies of sodium cholate micelles and phospholipids. (D)
ZAMBORINI, FRANCIS P. (b.1971) Associate Professor. B.A, 1993, Carthage College; Ph.D, 1998, Texas
A&M University. Postdoctoral Research Associate,
1998-2001, University of North Carolina at Chapel Hill.
Analytical Chemistry. Analytical chemistry, materials,
electrochemistry, nanoscience. TEL: (502) 852-6550
FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/fpz.htm
Grzegorz W. Slawinski and Francis P. Zamborini, Synthesis and Alignment of Silver Nanorods and Nanowires and the
Formation of Pt, Pd, and Core/Shell Structures by Galvanic
Exchange Directly on Surfaces, Langmuir, 23, 10357-10365
(2007).
Aneta J. Mieszawska, Romaneh Jalilian, Gamini U. Sumanasekera and Francis P. Zamborini, The synthesis and fabrication of one-dimensional nanoscale heterojunctions, Small,
3, 722-756 (2007).
Francisco J. Ibanez and Francis P. Zamborini, Chemiresistive sensing of volatile organic compounds with films of surfactant-stabilized gold and gold-silver alloy nanoparticles,
ACS Nano, 2, 1543-1552 (2008).
Radhika Dasari and Francis P. Zamborini, Hydrogen
Switches and Sensors Fabricated by Combining Electropolymerization and Pd Electrodeposition at Microgap Electrodes,
J. Am. Chem. Soc, 130, 16138-16139 (2008).
Francisco J. Ibanez and Francis P. Zamborini, Reactivity of
Hydrogen with Solid-State Films of Alkylamine- and Tetraoctylammonium Bromide-Stabilized Pd, PdAg, and PdAu
Nanoparticles for Sensing and Catalysis Applications, J. Am.
Chem. Soc, 130, 622-633 (2008).
J. Parrino, Chemiresistive hydrogen sensors using Au/Pd
and Ag/Pd hexane-thiolate coated alloy monolayer-protected
clusters. (M)
A. Mieszawska, One-dimensional and branched gold nanostructures grown directly on surfaces: Assembly, patterning, formation of heterojunctions, and electrochemical/Raman scattering properties. (D)
F. J. Ibanez, Chemiresistive vapor and gas sensing with
metallic nanoparticles. (D)
ZHANG, XIANG (b.1967) Associate Professor. B.A,
1989, Lanzhou University; M.S, 1994, Institute of Modern Physics; Ph.D, 2001, Purdue University. Bioanalytical Chemistry. We are interested in multidisciplinary life
sciences research with expectation that the chemistry in
living systems can define disease mechanisms. Our bioanalytical research exploits high information throughput
technologies for the analyses of complex mixtures derived from living systems. Our bioinformatics research
develops informatics system that enables mining of high
volume content-rich data for the quantifcation of molecular networks and ‘systems level’ knowledge assembly.
TEL: (502) 852-8878 FAX: (502) 852-8149
Web: louisville.edu/a-s/chemistry/faculty/xz.htm
Email: x0zhan17@louisville.edu
X. Zhang, J. M. Asara, J. Adamec, M. Ouzzani and A. K.
Elmagarmid, Data processing in liquid chromatography mass
spectrometry based proteomics, Bioinformatics, 21, 40544059 (2005).
X. Zhang, W. Hines, J. Adamec, J. Asara, S. Naylor and F.
E. Regnier, An automated method for the analysis of stable
isotope labeling data for proteomics, J. Am. Soc. Mass Spectrom, 16, 1181-1191 (2005).
M. Ouzzani, W. G. Aref, E. Bertino, A. C. Christine, C. W.
Clifton, W. Hon, A. K. Elmagarmid, A. Ghafoor, S. E. Hambrusch, S. Prabhakar, J. Vitter and Z. Zhang, The Indiana
Center for database systems at Purdue University, SIGMOD
Record, 34, 53-58 (2005).
J. M. Asara, X. Zhang, B. Zheng, H. H. Christofk, N. Wu
and L. C. Cantley, In-gel stable isotope labeling: A strategy
for mass spectrometry based relative quantification, J. Proteome Res, 5, 155-163 (2006).
S. Pevtsov, I. Fedulova, H. Mirzadi, C. Buck and X.
Zhang, Performance evaluation of existing de novo sequencing algorithms, J. Proteome Res, 5, 3018-3028 (2006).
J. M. Asara, X. Zhang, B. Zheng, H. H. Cristofk, N. Wu
and L. C. Cantley, In-gel stable isotope labeling for relative
quantification using mass spectrometry, Nature Protocols, 1,
46-51 (2006).
Cheolhwan Oh, Stanislaw H. Zak, Hamid Mirzaei, Charles
Buck, Fred E. Regnier and Xiang Zhang, Neural network
prediction of peptide separation in strong anion exchange
chromatography, Bioinformatics, 23, 114-118 (2007).
Yongdong Zhao, James C. Fleet, Jiri Adamec, Doris E.
Terry, Xiang Zhang, Settor Kemeh, V. Jo Davisson and Connie M. Weaver, Effects of hindlimb unloading and bisphosphonates on the serum proteome of rats, Bone (San Diego,
CA, U. S.), 41, 646-658 (2007).
Xiang Zhang, Cheolhwan Oh, Catherine P. Riley and
Charles Buck, Current status of computational approaches
for protein identification using tandem mass spectra, Curr.
Proteomics, 4, 121-130 (2007).
Ruiqing Qiu, Xiang Zhang and Fred E. Regnier, A method
for the identification of glycoproteins from human serum by
a combination of lectin affinity chromatography along with
anion exchange and Cu-IMAC selection of tryptic peptides,
J. Chromatogr., B: Anal. Technol. Biomed. Life Sci, 845,
143-150 (2007).
Irina Fedulova, Zheng Ouyang, Charles Buck and Xiang
Zhang, PepTiger: search engine for error-tolerant protein
identification from de novo sequences, Open Spectrosc. J, 1,
1-8 (2007).
Kimberly Ralston-Hooper, Amber Hopf, Cheolhwan Oh,
Xiang Zhang, Jiri Adamec and Maria S. Sepulveda, Development of GCxGC/TOF-MS metabolomics for use in ecotoxicological studies with invertebrates, Aquat. Toxicol, 88, 4852 (2008).
Changyu Shen, Zhiping Wang, Ganesh Shankar, Xiang
Zhang and Lang Li, A hierarchical statistical model to assess
the confidence of peptides and proteins inferred from tandem
mass spectrometry, Bioinformatics, 24, 202-208 (2008).
Sudipto Saha, Scott H. Harrison, Changyu Shen, Haixu
Tang, Predrag Radivojac, Randy J. Arnold, Xiang Zhang and
Jake Yue Chen, HIP2: An online database of human plasma
proteins from healthy individuals, BMC Med. Genomics, 1,
No pp. given (2008).
Mingwu Zhang, Qi Ouyang, Alan Stephenson, Michael D.
Kane, David E. Salt, Sunil Prabhakar, John Burgner, Charles
Buck and Xiang Zhang, Interactive analysis of systems biology molecular expression data, BMC Syst. Biol, 2, No pp. given (2008).
Cheolhwan Oh, Xiaodong Huang, Fred E. Regnier, Charles
Buck and Xiang Zhang, Comprehensive two-dimensional gas
chromatography/time-of-flight mass spectrometry peak sorting algorithm, J. Chromatogr., A, 1179, 205-215 (2008).
Adam W. Culbertson, W. Brent Williams, Andrew G.
Mckee, Xiang Zhang, Keith L. March, Stephen Naylor and
Stephen J. Valentine, Inside the personalized medicine toolbox: GC × GC-mass spectrometry for high-throughput profiling of the human plasma metabolome, LCGC North Am, 26,
560,562-564,566-569 (2008).