Accenture Life Sciences Rethink Reshape Restructure…for better patient outcomes Accenture Technology Vision 2015 for Life Sciences Current as of 2/2015 2015 Technology Vision: Succeeding in the “We Economy” Companies are connected to a digital fabric and a global network that has the potential to touch all aspects of their business. This grand network of businesses, individuals and things has the power to introduce a new era in the digital age—the age of “digital ecosystems”. The Accenture Technology Vision 2015 surveyed the opinions of 1000+ C-suite and D-suite executives across industries from around the world about the technology trends. 100+ senior executives from life sciences firms participated in the survey across key developed and developing markets. Key digital trends and their likely impact were assessed in the survey. Copyright © 2015 Accenture All Rights Reserved. 2 2015 Technology Vision: Succeeding in the “We Economy” Life sciences companies get connected 9 out of 10 life sciences respondents believe that “industry boundaries will dramatically blur as platforms reshape industries into interconnected ecosystems” 70% of respondents believe that 60% plan to engage with 45% of respondents in developed the next generation of platforms will not be led by tech companies, but by industry players and leaders new digital partners in the industry in the next 2 years markets are already using industry platforms to integrate data with digital business partners, while 26% are experimenting with such platforms Copyright © 2015 Accenture All Rights Reserved. 3 2015 Technology Vision: Succeeding in the “We Economy” The Life Sciences Industry Boehringer Ingelheim, WellPoint and HealthCore Announce First Project Under Multi-Year Research Collaboration Novartis, Qualcomm to launch $100M “beyond the pill” investment fund Jan 2015 MobiHealthNews Nov 2014 Yahoo Finance Sanofi aims for outcomes with brand-new Chief Patient Officer 23andMe and Genentech in deal to research Parkinson’s treatments Mar 2014 FiercePharma Jan 2015 SFGate Jun 2014 FiercePharma The Liquid Biopsy Will Boost Revenue For Sequenom And Illumina Jan 2015 Seeking Alpha Genentech, PatientsLikeMe team to explore real-world experience GlaxoSmithKline is testing mobile health sensors for clinical trials Apr 2014 PharmaTimes Nov 2014 MobiHealthNews Copyright © 2015 Accenture All Rights Reserved. AstraZeneca to develop mHealth cardiovascular services Novartis, Merck KGaA use digital tracking in MS patients to up their competitive game Jun 2014 FiercePharma 4 Life Science Industry Landscape Macro Trends Economic Reality HC > GDP Reform Austerity Patent Cliff Outcomes-Based Reimbursement Market Changes Silver Tsunami 7Bn/Emerging Markets Chronic Diseases & Health/Wellness Product Changes Scientific Break-throughs Rise of Generics Globally Rise of Specialized Medicine Digital Disruption Collaboration Platforms Consumerization of Healthcare Data-Driven Enterprise Business Model Disruption The “Outside In” Enterprise Convergence The Pivot to the Patient Source: Accenture Research Jan-15. Copyright © 2015 Accenture All Rights Reserved. Source: Accenture Research based on Capital IQ Nov 2014 Accenture estimates that digital disruption has the potential to unlock more than $100 billion of commercial value in the US alone, over a five-year period through new digital business models. Who will capture the lion’s share of the market and money. Will it be traditional players in life sciences? Players from other segments of the healthcare industry? Companies from consumer products, high tech, or communications? Or will entirely new companies emerge to seize the prize? Hot trend 5 Five trends prove that digital is dramatically influencing the industry today, and well into tomorrow. Copyright © 2015 Accenture All Rights Reserved. 6 1. The Internet of Me: Healthcare personalized Welcome to the era of highly personalized care, monitoring and treatment, building trust through meaningful patient experiences. Copyright © 2015 Accenture All Rights Reserved. 7 1. The Internet of Me: Healthcare personalized Forward thinking businesses are capturing mindshare by creating highly personalized, delightful digital experiences that engage and exhilarate consumers, while maintaining their trust. HOW IS THE LIFE SCIENCES INDUSTRY IMPACTED? 1. Engage in the wellness revolution 2. Personalize the patient journey There is a huge opportunity to digitally engage in disease prevention, monitoring and treatment. Apps and wearables are being used to promote general wellness and treatment delay or prevention. The nature of access points is changing as the focus is shifting to patient journeys and creating delightful digital experiences. Channels are evolving from the Internet to mobile to the Internet of things, which is now getting personal, benefiting the patient. Copyright © 2015 Accenture All Rights Reserved. 3. Establish and maintain trusted, digital havens To succeed in creating highly personalized experiences life sciences companies must create a bond of trust between them and the patient, for service adoption to flourish. 8 1. The Internet of Me: Healthcare personalized >$4.6B incremental revenue in 5 years In the US branded pharmaceutical market, customer experience could drive $4.6B in incremental revenue, according to Accenture Analysis.¹ EXAMPLES WellDoc’s BlueStar®, recently approved by the FDA, this platform is the first mobile prescription therapy for type 2 diabetes. It provides realtime motivational, behavioral and educational coaching to help patients self-manage their diabetes treatment plan and is reimbursable by insurers. PhysIQ, a device-agnostic analytics platform is being used by healthcare professionals to leverage new types of data being generated by IoT devices such as fitness trackers. It can pull data from any combination of devices, aggregate it, and deliver a single, comprehensive health score which is intimately personalized: data is constantly generated by whichever devices the user chooses, and the platform learns individual habits and tendencies over time. • Ownership of consumer wearables is expected to double year on year by 2016 • 73% of the life sciences IT and business executives we surveyed report either using or experimenting with wearables and smart objects to engage customers, employees or partners • 75% of survey respondents place the personalized customer experience in their top three priorities – 25% report it as their top priority Copyright © 2015 Accenture All Rights Reserved. 9 2. Outcome Economy: Hardware producing health results New intelligence in embedded hardware and sensors is giving patients and healthcare providers what they really want: better health outcomes. Copyright © 2015 Accenture All Rights Reserved. 10 2. The Outcome Economy: Hardware producing hard data Intelligent hardware is bridging the last mile between digital enterprises and the physical world. The IOT is creating opportunities to understand what customers are really trying to achieve and providing feedback on value, moving from selling things to results. HOW IS THE LIFE SCIENCES INDUSTRY IMPACTED? 1. Drive patient outcomes Smart, thoughtful patient services are now possible using accessible, competent hardware. With sensitive, significantly less expensive sensors and highly connected hardware, it will become easier to personalize care, measure value and target desired outcomes. Copyright © 2015 Accenture All Rights Reserved. 2. Adapt to a risk-adjusted pricing world Cloud based real-world big data along with real-time patient monitoring will help drive value analytics, providing insights into patient outcomes that will ultimately drive successful value based pricing arrangements. 3. Re-invent R&D Digital hardware is now sufficiently evolved to enable a re-invention of life sciences R&D. Using diagnostic apps, smart pills, remote patient wearables, almost every aspect of the R&D process is ripe for focusing on outcomes. 4. Own the platforms of the upcoming sharing economy Care coordination through collaboration and data exchange is receiving increased emphasis, providing opportunities for life sciences companies to participate in the outcome economy. 11 2. The Outcome Economy: Hardware producing hard data $1.4B If converting activities into currency promotes an increase in medication adherence of even just 20 percent, total healthcare spending could be reduced by $1,074 annually for every person with diabetes. The total savings would be $1.4 billion in the US.² EXAMPLES Proteus Digital Health is focused on improving patient outcomes by integrating a tiny, inert sensor in the pills it produces. The sensor acts in concert with a wearable device and mobile app to provide full “adherence transparency” for patients, healthcare providers and payers. The Proteus hardware-based system determines when patients take their medications and also can send alerts and reminders to the individual if they forget to take a pill. A pressure sensor has been used in the development of a smart contact lens called Triggerfish, which can measure, monitor, and control intra-ocular pressure levels for patients as well as catch early cases of glaucoma. It monitors this pressure for 24 hours and then provides a record to the attending physician. A leading pharma company* wanted to understand which diabetes patients were not achieving the best clinical and emotional outcomes, so that it could proactively work with doctors and patients to better manage the disease. The company used predictive intelligence and analytics expertise to see exactly why and where patients fall short of successfully managing the disease, helping it to strongly advocate for specific treatment standards. • 85% life science respondents believe that more intelligent hardware, sensors, and devices on the edge of networks will lead to the industry shifting from selling products to selling outcomes • 86% of life sciences respondents believe that embedded intelligence will deliver better outcomes for customers Copyright © 2015 Accenture All Rights Reserved. 12 3. The Platform (R)evolution: Defining ecosystems, redefining Life Science Healthcare IT platforms capture data from disparate sources (e.g., wearables, phones, glucometers), and connect them bringing a new era of personalized treatment through innovative patient services. Copyright © 2015 Accenture All Rights Reserved. 13 3. Platform Revolution: Defining ecosystems, redefining Life Science Digital Industry Platforms and ecosystems are fuelling the next wave of breakthrough innovation and disruptive growth. Large companies are finding new ways of connecting – letting others innovate for them, creating value for the enterprise through collaboration and innovation. HOW IS THE LIFE SCIENCES INDUSTRY IMPACTED? Platform businesses are changing the world. According to Massachusetts Institute of Technology, “In 2013, 14 of the top 30 global brands by market capitalization were platform oriented companies—companies that created and now dominate arenas in which buyers, sellers, and a variety of third parties are connected in real time.”3 For life sciences we see potential for disruptors to emerge in four key ecosystems: Provider – allowing two-way external and internal collaboration that enables control of decision access points and supports current functions within clinical operations and commercial operations. Copyright © 2015 Accenture All Rights Reserved. Patient – designed to support patients end to end including trial recruitment, pre-market awareness, intelligent patient services and smart population management designed to drive outcomes. Product – optimized to bring about the right stakeholders to solve for right pills, services, diagnostic apps that can be effectively monetized. Regulatory and reimbursement – should generate high-quality compliant content for approvals, pricing and risk management , supporting current functions such as reg. affairs., HEOR, Med affairs, academic partnerships etc. 14 2. The Outcome Economy: Hardware producing hard data $19.2B For each type 2 diabetes patient, at least $697 per year could be saved by using digitally accessed intermediaries and remote monitoring for diagnosis and treatment— resulting in total annual savings of $19.2 billion.4 EXAMPLE Accenture Intelligent Patient Platform is an end to end platform supporting the end to end patient journey. It is built on the Salesforce platform, to enable the design of more precise patient programs based on unique patient segment requirements. It is currently being implemented or piloted by several major global life science companies. Eisai, Merck, Pfizer and others have joined together to build a standards-driven platform to help pharmaceutical companies simplify and speed drug development. Accenture Life Sciences Cloud for R&D brings together multiple internal and external data sources across non-competitive areas in clinical, safety, regulatory and operational functions into a single analytics platform, creating actionable insights to accelerate drug development and improve patient outcomes. • 80% of the LS survey respondents are strengthening digital capabilities by taking part in open innovation, using APIs to exchange data and technology to delivery better outcomes to partners and customers • 31% are using Industry platforms to integrate data with digital business partners and 41% are experimenting Copyright © 2015 Accenture All Rights Reserved. 15 4. Intelligent Enterprise: Huge data, smarter systems, better healthcare solutions A data explosion, accompanied by advances in processing power, health analytics and cognitive technology, is fueling software intelligence. Medical devices and wearables can now recognize, “think” and respond to make rapid better informed decisions. Copyright © 2015 Accenture All Rights Reserved. 16 4. Intelligent Enterprise: Huge data, smarter systems, better healthcare solutions With an influx of big data and advances in processing power, data science and cognitive technology, software intelligence is helping machines make better informed decisions. Software intelligence will drive new levels of evolution and discovery. HOW IS THE LIFE SCIENCES INDUSTRY IMPACTED? 1. Establish the data supply chain • Commercial - provide payers the real world evidence for value of drugs. • R&D - improving predictive models – to evaluate patient risks based on a wider set of sources and to target specific patient populations. • Medical – improved patient safety through rapid signal detection of adverse events, including wider sources of data, including social media. Copyright © 2015 Accenture All Rights Reserved. 2. Invest in software intelligence to improve big-data analytical capabilities • To incorporate growing volume and variety of data ranging from lab and imaging, remote monitoring sensor data to social posts etc. • Early insight - The FDA’s recently announced it is collaborating with online patient network PatientsLikeMe to determine how patientreported data can give new insights into drug safety. • Intelligent decision making - Isabel Healthcare, offers a web-based system designed to assist clinicians in diagnosing rare diseases. The dynamic diagnosis checklist is provided as a standalone tool or fully integrated with electronic records. 17 4. Intelligent Enterprise: Huge data, smarter systems, better healthcare solutions $1.9B In value annually Using treatment algorithms and automation to replace routine diabetesrelated decisions could help to prevent misdiagnoses lead to higher costs and could save $1.9 billion annually.5 EXAMPLE Bryn Roberts, global head of R&D operations at Roche in Switzerland, says, “A century’s worth of Roche R&D data were more than doubled in 2011-2012 in a single large-scale experiment to sequence hundreds of cancer cell lines.” To derive more value from these data sets Roche is collaborating with Point Cross to create a data platform that allows flexible searching of data from the past 25 years of Roche studies, including those outsourced to CROs. Those data, along with information about thousands of compounds, will be mined to develop new drugs. Roche: http://www.sciencemag.org/site/products/lst_20140613.xhtml • Over 40% of life sciences companies surveyed expect to see data volumes increase by at least 50% in the coming year • Only 28% of businesses believe they are generating strategic value from the data they collect and 40% admit they need a plan to take advantage of big data • IDC predicts 44 Zettabytes of data by 2020. 10% will come from 32 Bn connected devices, more than twice the number today Copyright © 2015 Accenture All Rights Reserved. 18 5. Workforce Reimagined: Collaboration at the intersection of humans and healthcare As the digital revolution gains momentum, scientists and life science professionals are now using machines to be more efficient, provide better decisions and take on increasingly more complex tasks. Copyright © 2015 Accenture All Rights Reserved. 19 5. Workforce Reimagined: Collaboration at the intersection of humans and healthcare The push to go digital is amplifying the need for humans and machines to do more, together. There will be a shift from labor-driven technology-enabled paradigm to a digital-driven, human-enabled model advances in natural interfaces, wearable devices, and smart machines will present new opportunities for companies to empower their workers through technology. HOW IS THE LIFE SCIENCES INDUSTRY IMPACTED? 1. Augment workforce productivity 2. Expand training Augmented devices (e.g., smart glasses, wearables, immersive technologies, and NLP) providing more portability, insights, and unprecedented contextual information to scientists, clinicians, and doctors during the research, drug development and clinical trials process. Life sciences companies will need to identify how to train and certify both human and machine interfaces for R&D, manufacturing, and sales divisions. Copyright © 2015 Accenture All Rights Reserved. 20 5. Workforce Reimagined: Collaboration at the intersection of humans and healthcare 30% reduction in total cost of ownership in 2018 Gartner predicts that by 2018, the total cost of ownership for business operations will be 30 percent lower than today because of the wider use of smart machines and industrialized services.6 EXAMPLES Accenture and Philips demonstrated how a doctor wearing Google Glass in an operating room could use the display to monitor a patient’s vital signs while performing surgical procedures, all without turning away from the patient molecules. Copyright © 2015 Accenture All Rights Reserved. Surgeons at Indiana University Health Methodist Hospital have used Google Glass assistance during the removal of abdominal tumors. Augmented devices were able to provide doctors additional degrees of freedom, portability, and insights about the patients. Baxter’s Home choice Pro is a peritoneal dialysis (APD) system that allows the doctor to remotely monitor the therapy. The information captured by the doctor can help decide if changes to the treatment or prescriptions are required. Boehringer Ingelheim partnered with Kaggle, the gamification platform provider, to leverage skills of data scientists to create a new model that will accurately predict the biological response of molecules. 21 5. Workforce Reimagined: Collaboration at the intersection of humans and healthcare 74% of all life sciences respondents believe that companies will need to focus on training their machines as much as they do on training their people (e.g., using intelligent software, algorithms and machine learning) Copyright © 2015 Accenture All Rights Reserved. Natural language processing to grow to a $10B market by 2018 growing at 20% each year over the next few years7 22 To capture the bigger prize, life sciences companies must embrace digital holistically to improve patients' quality of life and capture the more than $100 billion of commercial value in the US over the next 5 years.8 Life Sciences companies from within and outside the traditional life sciences industry must embrace digital to design and build entirely new business models that are dramatically changing the healthcare industry. They need to go beyond the confines of traditional industry, product and customer boundaries to find entirely new ways to meet address customer needs. Copyright © 2015 Accenture All Rights Reserved. 23 References 1 Capturing the $100 billion opportunity for Life Sciences: are you a digital transformer or follower? Accenture 2015. 2 Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. “The Ups and Downs of Dynamic Pricing,” Innovation@Work blog, October 31, 2014. http://executive.mit.edu/blog/the-ups-and-downsofdynamic-pricing#.VG4yA_nF-bU. 3 4 Capturing 5 the $100 billion opportunity for Life Sciences: are you a digital transformer or follower? Accenture 2015. Capturing the $100 billion opportunity for Life Sciences: are you a digital transformer or follower? Accenture 2015. “Gartner Reveals Top Predictions for IT Organizations and Users for 2015 and Beyond,” Gartner, October 7, 2014. http://www.gartner.com/newsroom/id/2866617. 6 “Natural Language Processing (NLP) Market worth $9,858.4 Million by 2018,” Markets and Markets, October 2013. http://www.marketsandmarkets.com/PressReleases/natural-language-processing-nlp.asp. 7 8 Capturing the $100 billion opportunity for Life Sciences: are you a digital transformer or follower? Accenture 2015. Copyright © 2015 Accenture All Rights Reserved. 24