Institution
UCSD
POSITION: Associate Professor of
Bioengineering
NAME: Lanping Amy Sung
Education / Training
Institution or Location
Degree
Year(s)
National Taiwan Univ., Taipei, Taiwan
B.S.
1971
College of William & Mary,
Williamsburg, VA
M.A.
1975
Ph.D.
1983
Columbia University, New York, NY
Field of Study
Phytopathology
& Entomology
Biology
Human Genetics and
Development
A. POSITION AND SELECTED HONORS
1983-1988
Staff Associate and Associate Research Scientist, Department of Physiology
and Cellular Biophysics, Columbia University, New York, NY
1988-1994
Associate Research Bioengineer and Lecturer, Department of Applied
Mechanics and
Engineering Sciences-Bioengineering, University of California,
San Diego, La Jolla, CA
1989-present Member, Center for Molecular Genetics, University of California, San Diego, La
Jolla, CA
1994-1997
Associate Professor in Residence, Department of Bioengineering, University of
California,
San Diego, La Jolla, CA
1997-present Associate Professor, Department of Bioengineering, University of California,
San Diego, La Jolla, CA
B. SELECTED PEER-REVIEWED PUBLICATIONS
Chien S, Sung LA, Kim S, Burke AM, Usami S. Determination of aggregation force in rouleaux
by fluid mechanical technique. Microvasc. Res. 13:327-333, 1977.
Somer H, Chien S, Sung LA, Thurn A. Erythrocytes in Duchenne dystrophy: Osmotic fragility
and membrane deformability. Neurology 29:519-522, 1979.
Chien S, Sung LA, Skalak R. Energy balance in red cell aggregation. Bibl. Anat. 20:207-210,
1981.
Sung LA, Kabat EA, Chien S. Interaction of lectins with membrane receptors on erythrocyte
surfaces. J. Cell Biol. 101:646-651, 1985.
Sung LA, Kabat EA, Chien S. Interaction energies in lectin-induced erythrocyte aggregation. J.
Cell Biol. 101:652-659, 1985.
Sung K-LP, Sung LA, Crimmins M, Burakoff SJ, Chien S. Determination of junction avidity of
cytolytic T cell and target cell. Science 234:1405-1408, 1986.
Reinhart W, Sung LA, Chien S. Quantitative relationship between Heinz body formation and red
blood cell deformability. Blood 68:1376-1383, 1986.
Chien S, Sung LA. Physicochemical basis and clinical implications of red cell aggregation.
Clin. Hemorheol. 7:71-91, 1987.
Sung KLP, Sung LA, Crimmons M, Burakoff SJ, Chien S. Biophysical basis of cell killing by
cytotoxic T lymphocytes. J. Cell Sci. 91:179-189, 1988.
Sung LA, Chien S, Chang, L.-S., Lambert, K., Bliss, SA, Bouhassira, EE, Nagel, RL., Schwartz,
RS, Rybicki, AC. Molecular cloning of human protein 4.2: A major component of the red
cell membrane. Proc. Natl. Acad. Sci. (USA) 87:955-959, 1990.
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Sung, LA, Fowler, VM, Lambert, K, Sussman, M, Karr, D, Chien S. Molecular cloning and
characterization of human fetal liver tropomodulin: A tropomyosin-binding protein. J. Biol.
Chem. 267:2616-2621, 1992.
Sung LA, Chien S, Fan, Y-S, Lin CC, Lambert K, Zhu L, Lam JS, Chang L-S. Human
erythrocyte protein 4.2: Isoform expression, differential splicing and chromosomal
assignment. Blood 79:2763-2770, 1992.
Chien S, Sung LA, Lee MML, Skalak R. Red cell membrane elasticity as determined by flow
channel technique. Biorheology 29:467-478, 1992.
Sung LA, Lin JJC. Erythroyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin
isoform encoded by the γ-tropomyosin gene. Biochem. Biophys. Res. Commun.
201:627-634, 1994.
Sung, LA and Kabat, EA. Agglutination induced erythrocyte defprmation by two blood group Aspecific lectins: Studies by light and electron microscopy. Biorehology. 31:353-364. 1994.
Sung K-LP, Yang L, Whittemore DE, Shi Y, Jin G, Shieh AH, Akeson WH, Sung LA. The
differential adhesion forces of anterior cruciate and medial collateral ligament fibroblasts:
Effects of tropomodulin, talin, vinculin, and -actinin. Proc. Natl. Acad. (USA) 93: 91829187, 1996.
Chu X, Chen, J Chien KR, Vera, C, Sung LA. The effect of targeted disruption of the
tropomodulin gene in mice. BMES/EMBS-99, 15.2.3-1, 1999.
Sung LA, Gao KM, Yee LJ, Temm-Grove CJ, Helfman DM, Lin J-JC, Mehrpouryan M.
Tropomyosin isoform 5b is expressed in human erythrocytes: Implications of
tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal
organization of membrane skeletons. Blood 95:1473-1480, 2000.
Vera C, Sood A, Gao K-M, Yee LJ, Lin JJC, Sung LA. Tropomodulin-binding site mapped to
residues 7-14 at the N-terminal heptad repeats of human tropomyosin isoform 5. Arch.
Biochem. Biophys. 378:16-24, 2000.
Chu X, Thompson D, Yee L, Sung LA. Genomic organization of mouse and human Etropomodulin genes encoding the pointed end capping protein for actin filaments. Gene
256:271-281, 2000
Sung LA. Molecular basis of cell membrane mechanics (Chapter 9). In Introduction to
Bioengineering. Ed. YC Fung. World Scientific Publishing Co., Ltd. pp 217-235, 2001.
Chu X, Chen J, Reddy, M, Vera C, Sung, KLP, Sung LA. E-Tmod capping of actin filaments at
the slow-growing end is required to establish mouse embryonic circulation. Am. J.
Physiol. Heart Circ. Physiol. H1827-H1838, 2003.
Sung LA, Vera V. Protofilament and hexagon: A three-dimensional mechanical model for the
junctional complex of the erythrocyte membrane skeleton. Annals of Biomedical
Engineering 31:1314-1326, 2003.
Blatnik, J., Sung LA, Schimd-Schönbein, GW. The influence of fluid shear stress on the
remodeling of the embryonic primary capillary plexus. Biomechanics and Modeling in
Mechanobiology. 4:211-220, 2005.
Vera, C, Skelton, R, Bossens, F, Sung LA. 3-D mechanics of a junctional complex in the
erythrocyte membrane skeleton in equibiaxial and anisotropic extension. Annunals of
Biomedical Engineering. 33:1043-1054, 2005.
Vera, C, Lao, J, Hamelberg, D, Sung, LA. Mapping the tropomyosin isoform 5 binding site on
human erythrocyte tropomodulin: Further insights into E-Tmod/TM5 interaction. Archives
of Biochemisty and Biophysics. 444:130-138, 2005.
Zhu, Q, Vera, C, Asaro, R, Sche, P, and Sung, L.A. A hybrid model for erythrocyte membrane:
A single unit of protein network coupled with lipid bilayer. Biophysical Journal. (Accepted)
2007.
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