CV
IRA S. KRULL - PROFESSIONAL RESUME - ABBREVIATED (8/8/05)
EXPERIENCE
1984-2005 Associate Professor of Chemistry, Department of Chemistry,
Northeastern University, Boston, MA 02115
1979-1992 Senior Scientist and Faculty Fellow, The Barnett Institute,
Northeastern University, Boston, MA 02115
1977-1979 Senior Scientist, New England Institute for Life Sciences,
Thermo Electron Corporation, 125 Second Avenue, Waltham, MA 02154
1973-1976 Assistant Scientist, Boyce Thompson Institute for Plant Research,
Yonkers, NY 10591
EDUCATION
1970-1973 The Weizmann Institute of Science, Rehovot, Israel, Weizmann
Fellow, Senior Post-Doctoral Fellow
1969-1970 Union Carbide Corporation, Union Carbide Research Institute,
Tarrytown, NY 10591, UCC Post-Doctoral Fellow
1967-1968 University of Wisconsin, School of Pharmacy, Madison, WI,
National Institutes of Health Post-Doctoral Fellow
1968 Ph.D. in Organic Chemistry, New York University, NYC
1966 M.S. in Organic Chemistry, New York University, NYC
1962 B.S. in Chemistry (cum laude), City College of New York (CUNY), NYC
HONORS
1957-62 City College of New York: Dean's List, Honors in Chemistry on
graduation, National Science Foundation undergraduate research awards, top 10% of
graduating class.
1964-67 New York University: Teaching Fellow, National Institutes of Health
Pre-Doctoral Fellow, NYU Summer Research Graduate Fellowship, Founder's Day
Award (top 10% of class), Phi Lambda Upsilon Honorary Society, Sigma Xi Honorary
Society, New York State Scholar Incentive Awards.
1983 The Barnett Institute Innovative Research Award for Research into
Photoelectrochemical Detection for HPLC/FIA
1986 NIH-Small Business Innovation Research (SBIR) Award, Phase I, joint
with Cambridge Analytical Associates, Inc., Boston, MA (six month grant)
1987 Commonwealth of Massachusetts, Massachusetts Centers of Excellence
Corporation Grant Award, Polymer Science Division, co-PI with Waters
Chromatography Division, Millipore Corporation, 1 year award.
1988 Bioanalytical Systems, Inc., Recognition of Outstanding Achievement
Award for Five Years of Photoelectrochemical Detector Research, January, 1988.
1988 American Association for Clinical Chemistry, Inc. (AACC) 1987
Outstanding Speaker Award.
1988 Invited contributor to McGraw-Hill's Encyclopedia of Science and
Technology, Seventh Edition, 1988-89.
1988 American Association of Pharmaceutical Scientists Recognition Award,
for Invited Presentation at Eastern Regional Meeting, Atlantic City, NJ, June
8, 1988.
1990 Ciba-Geigy Corporation, Analytical Research Department, Visiting
Sabbatical Professor, Basel, Switzerland, Fall, 1990.
1991 Bioanalytical Systems, Inc. and Purdue University, Visiting Scholar,
W. Lafayette, IN, Fall, 1991.
1993-95 NSF Undergraduate Faculty Enhancement Workshop at NU, Summer,
1993-94, invited lectures: Enhancing Undergraduate Analytical Chemistry Curricula.
1994 International Symposium on Solid Phase Extraction, Amsterdam,
Holland, November 28-29, 1994, invited lecture: Immobilized reagents for solid phase
extraction and simultaneous derivatizations in HPLC and HPCE.
1995 New York Chromatography Society, 1-day symposium, invited lecture,
Perkin-Elmer Corporation, Norwalk, CT, May 17, 1995. Research and teaching of
capillary electrophoresis.
1995 Analytical Chemistry/Biochemistry short course, American Chemical
Society (USA) and Teva Pharmaceuticals Industries, Ltd., Netanya, Israel,
September, 1995.
1996 4th Hyphenated Techniques in Chromatography meeting, invited lecture,
Bruges, Belgium, February, 1996.
1996 Scientific Organizing Committee, 5-6 Hyphenated Techniques in
Chromatography meeting, Bruges, Belgium, February, 1998, 2000.
1997 Scientific Organizing Committee, Pharmaceutical and Biomedical
Analysis Symposium, Washington, DC, 1999.
1998-00 Central New England Chromatography Council, Executive Board Member.
2000-02 Scientific Organizing Committee, Hyphenated Techniques in
Chromatography (HTC-6, HTC-7).
2001 Precision Detectors, Pioneer in Research Award for Applications in
Laser Light Scattering Detection in SEC/HPLC for Biopolymers.
2003 Strathmore’s Who’s Who, Honored Member, 2003-04 Edition.
2004 AcademicKeys Who's Who in Sciences Higher Education (WWSHE).
2004 NIH-SBIR Ad Hoc Review Panel, August, 2004, invited
reviewer-Proteomics.
PROFESSIONAL AND HONOR SOCIETIES, BIOGRAPHICAL WORKS
American Chemical Society (Organic and Analytical); American Association for
the Advancement of Science (AAAS); Society for Electroanalytical Chemistry
(SEAC); Phi Lambda Upsilon (National Honor Society-Chemistry); Sigma Xi (National
Honor Society-Chemistry); American Men and Women of Science (1982-); Who's
Who in the East (U.S.)(1982-); Who's Who in Frontier Science and Technology
(1984-); Dictionary of International Biography (1984-); The International Who's
Who of Contemporary Achievement (1985-); Who’s Who (1994-); Who’s Who in
Science and Engineering (1985-).
REVIEW AND ADVISORY BOARDS
NIH-Small Business Innovation Research (NIH-SBIR) Study Section, 1983; NIH
Special Study Section and Site Visit, University of Washington, 1983; NIH-SBIR
Study Sections: 1984, 1986, 1988; NIH-SBIR Study Section and Site Visit, 1984;
U.S. Food and Drug Administration (FDA), Boston District Office Science
Advisor (1980-); National Science Foundation Proposal Reviewer (1983-); FDA Ad Hoc
Research Review Committee, 1985-1991; NIH Special Study Section, Academic
Research Enhancement Awards, 1985; FDA Ad Hoc Peer Review Panel, 1986; ACS
Petroleum Research Fund Proposal Reviewer (1985-); National Research Council
Fellowship Programs Panelist (1998-); FDA Science Advisor-Research Associate
Program
(SARAP)(1983-87); Editorial Review Boards: Trends in Analytical Chemistry
(1985-93); J. Liquid Chromatography (1985-91); J. Pharm. Biomed. Anal. (1987-93);
BioTechniques/BioChromatography (1989-); Analytical Letters (1989-01);
Analytical Chemistry (1997-1999); J. Capillary Electrophoresis (1998-01); Northeastern
University Council on Research and Scholarship (1989-92); Central New England
Chromatography Council (1997-01); J. Liquid Chromatography and Related
Techniques (1999-2001); Biomedical Chromatography (1998-2001);
CONSULTING ARRANGEMENTS
Thermo Separation Products, R&D Department, Riviera Beach, FL (1987-95);
Bioanalytical Systems, Inc., R&D Department, West Lafayette, IN (Science Advisory
Board)(1982-95); Isco, Inc., R&D Department, Lincoln, NE (1990-93);
BioChromatography Journal, Eaton Publishing Corp., Natick, MA (1991-95); Sippican,
Inc.,R&D Department, Marion, MA (1992-93); Advanced Surface Technology, Inc.,
R&D
Department, No. Billerica, MA (1992-93); SmithKline Beecham Pharmaceuticals
Corporation, Pharmaceutical Analysis Department, King of Prussia, PA (1993-95);
Waters Corporation, Chemical Products Group R&D (1993-95); Pfizer, Inc.,
Analytical Research Department, Groton, CT (1981-95); Genentech Corporation,
Medicinal and Analytical Chemistry Group, South San Francisco, CA (1990-96); Biogen
Corporation, Protein Process Chemistry Group, Cambridge, MA (1992-95); The
Pharmacia and Upjohn Pharmaceutical Company, Animal Health and Drug Metabolism
Department, Kalamazoo, MI (1993-96); Research Biochemicals, Inc., Research and
Development Department, Natick, MA (1992-96); Teva Pharmaceutical Industries,
Ltd., Analytical R&D Department, Netanya, Israel (1994-96); Hybridon, Inc.,
Worcester, MA, Analytical R&D Department (1995); U.S. Food and Drug
Administration
(1995-); Wyeth-Ayerst Research Laboratories, Inc. (1995-); Troy Chemical
Corp., Newark, NJ (1990-); Troy BioSciences, Inc., Newark, NJ (1995-);
Boehringer-Mannheim Corporation, Concord, CA (1996-); Isolation Technologies, Inc.,
Hopedale, MA (1996-); Zeneca Pharmaceutical Company, Wilmington, DE (1996-);
Merck
Research Laboratories,. Rahway, NJ (1996-); Waters Corporation, Pharmaceutical
Market Development Group (1995-); BASF Bioresearch, Worcester, MA (1998-01);
Dow Chemical USA, Midland, MI (1998-02); Geltex Pharmaceuticals, Waltham, MA
(2000-02); Waters Corporation (1997-2002); Eisai Pharmaceuticals, Andover, MA
(2001-02); Biogen Corporation (2000-01); DrugRiskSolutions, Schuylkill, NY
(2001-02); Eli Lilly and Company, Indianapolis, IN (2001-02); Philip Morris
Corporation, Richmond, VA (2000-01); Immunex Corporation, Seatle, WA (2001-02);
Institute for International Research (1999-01); Perkin-Elmer Corporation (2004-);
Amgen Corporation, Boulder/Longmont, CO (2004-05); Pfizer Corporation,Groton,
CT (2004-); Kenyon & Kenyon Law Firm, NYC (2005-); J. O’Shea Law Firm,
Boston(2004-); Wilmer Cutler Pickering Hale & Door Law Firm, Boston (2005-);
1997 Publications of Professor I.S. Krull Research Group
197. M.E. Szulc and I.S. Krull. Detection methods in HPLC, in Practical
HPLC Method Development, Second Edition, Edited by L. Snyder, J. Glajch, and
J.J. Kirkland, J. Wiley & Sons, Inc., NY, Chapter 3, 1997.
198. M.E. Szulc, P. Swett, and I.S. Krull. Size selective derivatizations
with polymer immobilized reagents. Biomed. Chromatogr., 11(3), 207 (1997).
199. I.S. Krull, M.E. Szulc, and J. Dai. Derivatizations in HPCE. A
Primer, Thermo Separation Products, Inc. ,1997.
200. I. S. Krull, B.-Y. Cho, R. Strong, and M. Vanderlaan. Principles and
practice of immunodetection in FIA and HPLC. LC/GC Intl. Magazine, 10(5), 278
(1997).
201. I. S. Krull, B.-Y. Cho, R. Strong, and M. Vanderlaan. Principles and
practice of immunodetection in FIA and HPLC. LC/GC Magazine, 15(7), 620 (1997).
202. R.-L. Qian, R. Mhatre, and I.S. Krull. Characterization of
antigen-antibody complexes by size exclusion chromatography (SEC) coupled with low
angle
light scattering photometry (LALLS) and viscometry. J. Chromatogr., A, 787,
101 (1997).
203. I.S. Krull, M. Swartz, and C. Gendreau. Regulations for chemists in
the drug and biotech industries. Today’s Chemist at Work, an ACS Publication,
26 (February, 1997).
204. B.-Y. Cho, R. Strong, G. Fate, and I.S. Krull. HPCE of a fermentation
derived, cyclic peptide analog, animal growth promotor. J. Chromatogr., 697,
163 (1997).
205. I.S. Krull, J. Dai, C. Gendreau, and G. Li. HPCE methods for the
identification and quantitation of antibodies, their conjugates and complexes. J.
Pharm. Biomed. Anal., 16, 377 (1997).
206. M.E. Swartz and I.S. Krull. Analytical Regulatory and Validation
Compliance Primer, Marcel Dekker, Inc., New York, 1997.
207. I.S. Krull, R. Strong, Z. Sosic, B.-Y. Cho, S. Beale, and S. Cohen.
Labeling reactions for minute amounts of proteins in HPLC and HPCE. J.
Chromatogr., B, Biomed. Applics., 699, 173 (1997).
208. I.S. Krull and M.E. Swartz. Introduction: national and international
guidelines. LC/GC Magazine, 15(6), 534 (1997).
209. I.S. Krull and M.E. Swartz. Method validation protocols- required
data elements, method transfer, and revalidation. LC/GC Magazine, 15(9), 842
(1997).
210. I.S. Krull and M.E. Swartz. Laboratory notebook documentation. LC/GC
Magazine, 15(12), 1122 (December, 1997).
1998 Publications of Prof. Krull’s Research Group
211. I.S. Krull and S.A. Cohen. Analytical Chemistry and Biotechnology,
invited Guest Editorial, LC/GC Magazine, International, 139 (March, 1998).
212. J. Dai and I.S. Krull. Thermal stability studies of immunoglobulins
(antibodies) using CIEF and CZE methods. J. Chromatogr., A, 807, 121 (1998).
213. J. Dai, G. Li, and I.S. Krull. Separation and quantitation of
monoclonal antibodies in cell growth medium using capillary zone electrophoresis. J.
Pharm. Biomed. Anal., 17, 1143 (1998).
214. M.E. Swartz and I.S. Krull. Validation of chromatographic methods.
Pharmaceutical Technology Magazine, 104 (March, 1998).
215. I.S. Krull and M.E. Swartz. Method validation requirements and
approaches in biotechnology. LC/GC Magazine, 16(3), 258 (1998).
216. R. Strong, B.-Y. Cho, G. Fate, and I.S. Krull. Derivatization
approaches for a fermentation derived, cyclic peptide analog. J. Chromatogr., 824, 25
(1998).
217. R. Stevenson, K. Mistry, and I.S. Krull. CEC ‘98: The
state-of-the-art. American Laboratory, 16A (August, 1998).
218. I.S. Krull and M.E. Swartz. Frequently asked questions about
analytical method validation. LC/GC Magazine, 16(5), 464 (1998).
219. I.S. Krull and M.E. Swartz.Determining limits of detection and
quantitation. LC/GC Magazine, 16(10), 922 (1998).
220. I.S. Krull and M.E. Swartz. Quantitation in method validation. LC/GC
Magazine, 16(12), 1084 (1998).
1999 Publications of Prof. Krull’s Research Group
221. I.S. Krull and M.E. Swartz. System suitability samples- what they
are, why we use them, and what they should do? LC/GC Magazine, 17(3), 244 (1999).
222. I.S. Krull and M.E. Swartz. Analytical method development and
validation for the academic researcher. Anal. Letters, 32(6), 1067 (1999).
223. I.S. Krull, A. Sebag, and R. Stevenson. Analysis of peptides,
proteins, and antibodies by capillary electrochromatography. J. Chromatogr., A, in
press (1999).
224. L.C. Santora, I.S. Krull, and K. Grant. Characterization of
recombinant human monoclonal tissue necrosis factor antibody using cation exchange
HPLC and capillary isoelectric focusing. Anal. Biochem., 275, 98 (1999).
225. H.J. Liu, B.-Y. Cho, R. Strong, I.S. Krull, S. Cohen, K.C. Chan, and
H.J. Issaq. Derivatization of peptides and small proteins for improved
identification and detection in capillary zone electrophoresis (CZE). Anal. Chim.
Acta, 400, 181 (1999).
226. I.S. Krull and M.E. Swartz. The International Conference on
Harmonization. LC/GC Magazine, 17(9), 836 (1999).
227. I.S. Krull and M.E. Swartz. Cleaning validation. LC/GC Magazine,
17(11), 1016 (1999).
2000 Publications of Prof. Krull’s Research Group
228. I.S. Krull, A. Sebag, and R. Stevenson. Analysis of peptides,
proteins, and antibodies by capillary electrochromatography. J. Chromatogr., A, 887,
137-163 (2000).
229. I.S. Krull and R. Strong. Liquid Chromatography-Derivatization.
Invited contribution to Encyclopedia of Separation Science, Academic Press, Ltd.,
UK, 2000, p. 583.
230. I.S. Krull, C. Gendreau, and H.J. Dai. Capillary electrophoresis in
combinatorial library analysis. In Analytical Techniques in Combinatorial
Chemistry, Edited by M.E. Swartz, Marcel Dekker, New York, 2000, Chapter 6.
231. I.S. Krull, R. Stevenson, K. Mistry, and M.E. Swartz. Capillary
Electrochromatography (CEC) and Pressurized Flow CEC (PEC) or Electro-HPLC, An
Introduction. HNB Publishers, New York, May, 2000.
232. I.S. Krull and M.E. Swartz. Regulatory review of method validation
protocols. LC/GC Magazine, 18(6), 620 (2000).
233. R. Strong, H.-J. Liu, B.Y. Cho, and I.S. Krull. Advantages and
limitations of derivatization of peptides for improved performance and detectability
in capillary isoelectric focusing (CIEF). J. Liquid Chrom. & Rel. Technol.,
23(12), 1775 (2000).
234. I.S. Krull. Reproducibility, reproducibility, and reproducibility,
Guest Editorial, American Laboratory, (November, 2000).
2001 Publications of Prof. Krull’s Research Group
235. S. Kazmi and I.S. Krull. Application of CEC to Biopolymers and
Pharmaceuticals. In Encyclopedia of Chromatography, Edited by J. Cazes, Marcel
Dekker, New York, 2001, pp. 49-58.
236. I.S. Krull. Adventures in Analytical
Chemistry/Biochemistry/Biotechnology. In A Century of Separation Science, Edited by
H. Issaq, Marcel Dekker,
Inc., New York, Chapter 44, pp. 693-709, 2001.
237. I.S. Krull, H.J. Liu, K. Mistry, and S. Kazmi. Industrial internships
(coops) in graduate school- how, when, why, and where? Anal. Letters, 34(1),
1 (2001).
238. J. Flarakos, I.S. Krull, and M.E. Swartz. Analytical validation
software. LC/GC Magazine, 19(3), 304 (2001).
239. H.J. Liu, R.E. Strong, I.S. Krull, and S.A. Cohen. Homogeneous
preparation of fluorescent derivatized insulin and its application to competitive
chromatographic immunoassays. Anal. Biochem., 298(1), 103 (2001).
240. H.J. Liu, B.-Y. Cho, I.S. Krull, and S.A. Cohen. Homogeneous,
fluorescent derivatization of large proteins. J. Chromatogr., A, 927. 77 (2001).
241. H.J. Liu, I.S. Krull, and S.A. Cohen. Femtomole peptide mapping by
derivatization, HPLC and fluorescence detection. Anal. Biochem., 294, 7 (2001).
242. L.C. Santora, P. Sakorafas, Z. Kaymakcalan, I.S. Krull, and K. Grant
Characterization of noncovalent complexes of recombinant, human monoclonal
antibody and antigen using cation exchange, size exclusion chromatography and
BiaCore. Anal. Biochem., 299(2), 119 (2001).
243. S. Kazmi and I.S. Krull. Proteomics and the current state of protein
separation science, Part I. PharmaGenomics Magazine, 14 (August, 2001).
244. S. Kazmi and I.S. Krull. Proteomics and the current state of protein
separation science, Part II. PharmaGenomics Magazine, 16 (October/November,
2001).
244. I.S. Krull and M.E. Swartz. Determining specificity in a regulated
environment. LC/GC Magazine, 19(7), 604 (2001).
245. R.C. Thompson, S. Morris, M.E. Swartz, and I.S. Krull. Method
validation for nutraceuticals. LC/GC Magazine, 19(11), 1142, (2001).
2002 Publications of Prof. Krull’s Research Group
246. A. El Shafey, G. Jones, H. Zhong, and I.S. Krull. Application of
affinity capillary electrophoresis for the determination of binding constants and
thermodynamic constants of enediynes with human serum albumin and histone.
Electrophoresis, 23(6), 945 (2002).
247. I.S. Krull, S. Kazmi, H. Zhong, and L.C. Santora. Separation of
glycoproteins by cIEF. In Methods in Molecular Biology, Volume 213: Capillary
Electrophoresis Separation of Carbohydrates, Edited by P. Thibault and S. Honda,
The Humana Press, Inc., Totowa, NJ, December, 2002, Chapter 12, pp. 197.
248. L.C. Santora, I.S. Krull, and K. Grant. Determination of recombinant
monoclonal antibodies and noncovalent antigen TNF-alpha using Q-TOF mass
spectrometry. Spectroscopy Magazine, 17(5), 50 (2002).
249. K. Mistry, H. Cortez, D. Meunier, C. Schmidt, N. Grinberg, and I.S.
Krull. Nonaqueous capillary electrochromatographic separation of synthetic,
neutral polymers by size exclusion chromatography using polymeric stationary
phases. Analytical Chemistry, 74, 617 (2002).
250. V. Grisanti, E.J. Zachowski, I.S. Krull, and M.E. Swartz. Operational
and performance qualification. LC/GC Magazine, Validation Viewpoint column,
20(4), 356 (2002).
251. P. Nader, G. Kremmydiotis, J. Tremblay, G., Levesque, A. Bartlett,
I.S. Krull, and M.E. Swartz. Validation of bioanalytical capillary gel
electrophoresis methods for the determination of oligonucleotides. LC/GC Magazine,
Validation Viewpoint column, 20(9), 856 (2002).
252. I.S. Krull. Reproducibility, reproducibility, and reproducibility,
revisited. Guest Editorial, American Laboratory, 34(20), 6 (2002).
253. K. Mistry, N. Grinberg, and I.S. Krull. CEC: an alternative to HPLC
and CE?, J. Sepn. Sci., 25(15-17), 935 (2002).
254. A.S. Rathore, R.R. Kurumbail, A.M. Lasdun, M.E. Swartz, and I.S.
Krull. Requirements for validating a capillary isoelectric focusing method for
impurity quantitation. LC/GC Magazine, 20(11), 1042 (2002).
255. I.S. Krull, Book Review, The Nucleus, LXXXI(3), 10 (November, 2002),
Doing Science: Design, Analysis, and Communication of Scientific Research.
2003 Publications of Prof. Krull’s Research Group
256. N. Jordan and I.S. Krull. Applications of affinity chromatography in
biotechnology, invited chapter in: Handbook of Affinity Chromatography, Edited
by D. Hage, Marcel Dekker, New York, in press (2005).
257. Y. Wang, I.S. Krull, C. Liu, and J. Orr.. Derivatization of
phospholipids. A review. J. Chromatogr., 793(1), 3 (2003).
258. I.S. Krull and B. Nunnally, Editors, Prions and Mad Cow Disease,
Analytical Chemistry. Marcel Dekker, New York, 2003.
259. Y. Wang, I.S. Krull, J. Orr, and C. Liu. Complexation with Iron at
sub-ppm levels in the HPLC analyses of phospholipids. Biomed. Chromatogr., 17,
149 (2003).
260. K. Mistry, I.S. Krull, and N. Grinberg. Capillary
electrochromatographic separation of polysaccharides by size exclusion chromatography
using
polymeric stationary phases. Electrophoresis, 24, 1753 (2003).
261. M.E. Swartz and I.S. Krull. Validation of bioanalytical methodsHighlights of the FDA’s guidance. LC/GC Magazine, 21(2), 136 (2003).
262. K. Millea and I.S. Krull. Approaches to subproteomics involving
chromatography. J. Liquid Chrom. & Related Tech., 26(14), 2195 (2003).
263. J. Orr, I.S. Krull, and M.E. Swartz. Validation of impurity methods .
Part 1, LC/GC Magazine, 21(7), 626 (2003).
264. J. Orr, M.E. Swartz, and I.S. Krull. Validation of impurity methods .
Part 2, LC/GC Magazine, 21(12), 1146 (2003).
2004 Publications of Prof. Krull’s Research Group
265. S. Schiavo, A. El-Shafey, N. Jordan, C. Orazine, Y. Wang, X. Zhou,
N.H. Chiu, and I.S. Krull. Immuno-PCR: an overview of the analytical technique
currently pushing the limits of detection. PharmaGenomics Magazine, invited
review, 36 (January, 2004).
266. B. Zhang, I.S. Krull, A. Cohen, D. Smisek, A. Kloss, B. Wang, and
A.J. Bourque. Separation of quaternary ammonium, diastereomeric oligomers by
capillary electrophoresis. J. Chromatography, 1034(1-2), 213 (2004).
267. G. Li, X. Zhou, Y. Wang, I.S. Krull, K. Mistry, N. Grinberg, and H.
Cortes. The analysis of synthetic organic, neutral polymers using nonaqueous
capillary gel electrophoresis (NACGE). J. Liquid Chrom. & Rel. Techs., 27(6),
927 (2004).
268. I.S. Krull and M.E. Swartz. Analytical method validation and true
quantitation. American Laboratory, Guest Editorial, 6 (February, 2004).
269. M.E. Swartz and I.S. Krull. Investigating Out-Of-Specifications
Results. LC/GC Magazine, 22(2), 132-136 (2004).
270. G. Li, X. Zhou, Y. Wang, A. El-Shafey, N.H.L. Chiu, and I.S. Krull.
cIEF and Affinity CE (ACE) approaches for the determination of binding
constants of prion antibodies. J. Chromatography,1053(1/2), 253-262 (2004).
271. M.E. Swartz, I.S. Krull, and J. McCabe. Training and complianceeasing the burden through cooperation with instrument vendors. LC/GC Magazine, 22
(9), 906 (2004).
272. M. Swartz and I.S. Krull. Setting specifications. LC/GC Magazine, 22
(6), 536 (2004).
2005 Publications of Prof. Krull’s Research Group
273. G. Li, M.E. Szulc, D.M. Fisher, and I.S. Krull. Derivatization for
Enhanced Electrochemical Detection. Invited review chapter in Electrochemical
Detection in Liquid Chromatography and Capillary Electrophoresis, Edited by P.T.
Kissinger, Marcel Dekker, Chromatographic Science Series, in press (2005).
274. S. Schiavo, W.-C. Yang, N.H.L. Chiu, and I.S. Krull. Comparison of
fluorometric detection methods for quantitative polymerase chain reaction (PCR).
J. Immunol. & Immunochem.,26(1), 1 (2005).
275. K. Millea, I.J. Kass, I.S. Krull, J.C. Gelber, and S.J. Berger.
Evaluation of multidimensional (ion exchange/reversed phase) complex protein
separations using linear and step gradients in the first dimension. J. Chromatogr.,
Special Issue, in press (May, 2005).
276. S.J. Berger, K.M. Millea, I.S. Krull, and S.A. Cohen. Middle-out
proteomics: incorporating multidimensional protein fractionation and intact
protein mass analysis as elements of a proteomic analysis workflow. In Separations
in Proteomics, Edited by G. Smejkal and A. Lazarev, Taylor and Frances,
Publishers, London, 2005.
277. I.S. Krull and M.E. Swartz. Analytical method validation: accuracy in
quantitation. LC/GC Magazine, 23/1, 46 (2005).
278. N. Jordan and I.S. Krull. Applications of affinity chromatography in
biotechnology, Handbook of Affinity Chromatography, Edited by D. Hage, Marcel
Dekker, New York, in press (2005).
279. L.C. Santora, K. Stainly, I.S. Krull, and K. Grant. Characterization
of an unknown derivative in transgenic human monoclonal tissue necrosis
factor-alpha antibody. Biomed. Chromatogr., submitted for publication, Biomed.
Chromatogr., 2005.
280. W. Patton, K. Cabrera, H. Hauck, N. Grinberg, S. Schiavo, V.
Panchagnula, and I.S. Krull. Planar electrochromatography and its applications to
amino acids, peptides, proteins, and proteomics. J. Liq. Chrom. & Rel. Tech.,
invited review article, in preparation, (2005).
2002 Scientific Presentations of Prof. Krull’s Research Group
454. Immunex Corporation, Analytical R&D Department, Seattle, WA, invited
lecture/visit, January 24-25, 2002. Invited seminar: Identification of trace
impurities formed from human, monoclonal antibodies in transgenic derived
goat’s milk.
455. Hyphenated Techniques in Chromatography, Bruges, Belgium, The Royal
Flemish Chemical Society, February 2-8, 2002, invited (plenary) lecture,
1/2-day short course, tutorial, poster papers (2). Title of invited paper:
Characterization of noncovalent complexes of recombinant human monoclonal antibody
and
antigen using cation exchange, size exclusion chromatography and BIAcore.
456. The Dow Chemical Company, Midland, MI, Analytical Sciences Division,
invited lecture in Analytical Sciences Symposium, February 18-19, 2002. Title
of presentation: 1. Characterization of noncovalent complexes of recombinant
human monoclonal antibody and antigen using cation exchange, size exclusion
chromatography and BIAcore. 2. Characterization of an unknown derivative in
transgenic, human monoclonal tissue necrosis factor-alpha antibody.
457. Millennium Pharmaceuticals Training Courses, Cambridge, MA, Tuesdays,
January 8, 22 and February 12, 26. University College arranged training
courses for Fall-Winter at Millennium.
458. University of Georgia, School of Pharmacy and Chemistry, Athens, GA,
invited lecture, March 7, 2001 (Jim Stewart, host), Title: Derivatizations of
proteins and peptides for improved performance and detectability in HPCE/CZE.
459. Pittsburgh Conference, March 17-22, 2002, New Orleans, LA, invited
lecture in Symposium on CEC/PEC and chair/organizer for Symposium on Prions and
Mad Cow Disease, Redux II.
460. 223rd ACS National Meeting, Orlando, FL, April 7-11, 2002, invited
lecture (N. Grinberg): Nonaqueous capillary electrochromatographic separation of
synthetic, neutral polymers by size exclusion chromatography using polymeric
stationarsy phases.
461. University of New Hampshire, Department of Chemistry, Durham, NH,
April 16, 2002 (R. Seitz, host), invited lecture: Determination of the structures
of trace, acidic impurities in a commercial, recombinant antibody.
462. Central New England Chromatography Council/GBMSDG annual symposium,
May 14, 2002, Northeastern University, poster paper presented: Nonaqueous
capillary electrochromatographic separation of synthetic, neutral polymers by size
exclusion chromatography using polymeric stationary phases (I.S. Krull).
463. HPLC 2002 International Symposium, June 3-7, 2002, Montreal, Canada,
invited presentation: Nonaqueous capillary electrochromatographic separation
of synthetic, neutral polymers by size exclusion chromatography using polymeric
stationary phases. (I.S. Krull)
464. June 12-13, 2002, Organogenesis Company, Canton, MA, 2-day seminar,
training course, thru NU’s Corporate Training Division, Dedham, MA.
465. August 17-22, 2002, ACS, Fall National Meeting, Boston, MA, invited
lectures (2), organizer of mini-symposium on Electrodriven, Capillary
Separations (with Luis Colon). Invited talk in D. Hage mini-symposium on AffinityBased
Separation Techniques in Pharmaceutical and Biochemical Analysis.
466. September 20-23, 2002, Visit to TheraVance, Inc., South San
Francisco, CA, presentation of 1-day short course and consulting trip with Don Schmidt.
467. October 4, 2002, External Examiner, Ph.D. Thesis Defense, Department
of Chemistry, Concordia University, Montreal, Canada. Invited seminar,
Chemistry Department, Title: Identification of trace impurities formed from human,
monoclonal antibodies in transgenic derived goat’s milk.
468. October 21-22, 2002, The Frederick Conference on HPCE, Frederick, MD,
invited talk on Size exclusion electrochromatography (SEEC) and NA-CGE for
the characterization of synthetic organic polymers and natural biopolymers.
2003 Scientific Presentations of Prof. Krull’s Research Group
469. January 17-23, 2003, HPCE 2003, 16th International Symposium on
Microscale Separations and Analysis, Manchester Grand Hyatt, San Diego, CA. Oral
presentation on: Capillary electrochromatographic separation of polysaccharides
by size exclusion chromatography using polymeric stationary phases.
470. February 5, 2003, Stonehill College, Easton, MA, invited seminar to
graduate students/faculty in Analytical Chemistry. Characterization of human,
monoclonal antibodies using CIEX, cIEF, and mass spectrometry methods.
471. ABRF (Association of Biomolecular Resources Facilities), The Protein
Society Meeting, Denver, CO, February 10-13, 2003, Poster paper submitted
together with Waters Corporation, Milford, MA: Prefractionation Strategies for
Proteomic Analysis (S.I. Berger, K. Millea, A.B. Chakraborty, I.S. Krull, and
S.A. Cohen).
472. Salem State College, Department of Chemistry, Salem, MA, April 28,
2003, invited lecture: Characterization of human, monoclonal antibodies using
CIEX, cIEF, and mass spectrometry methods.
473. May 13, 2003, Central New England Chromatography Council (CNECC) and
GBMSDG, 1/2-day symposium, poster papers (3) presented: 1) Complexation with
Iron at sub-ppm levels in the HPLC analyses of phospholipids (Y. Wang); 2)
Application of affinity capillary electrophoresis for the determination of binding
constants and thermodynamic constants of enediynes with human serum albumin
and histone (A. El Shafey); 3) Prefractionation strategies for proteomic
analysis (K. Millea).
474. American Society for Mass Spectrometry, annual meeting, Palais de
Congress, Montreal, Canada, June 8-12, 2003, poster paper: Prefractionation
Strategies for Proteomic Analysis (S.I. Berger, K. Millea, A.B. Chakraborty, I.S.
Krull, and S.A. Cohen).
475. The Protein Society, FASEB, National Meeting, July 26-30, 2003,
Boston, MA. Poster paper: Prefractionation Strategies for Proteomic Analysis (S.I.
Berger, K. Millea, A.B. Chakraborty, I.S. Krull, and S.A. Cohen).
476. September 7-11, 2003, ACS National Meeting, NYC, organizer/host/chair
1/2-day symposium on Analytical Chemistry of Prion Proteins (with Richard
Rubenstein). Invited presentation: Approaches for Improved Assays for Prion
Proteins in Simple Biofluids. Ira S. Krull, Norman Chiu, Neil Jordan, Ahmed
El-Shafey, Yonghui Wang, Susan Schiavo, Christina Orazine, Xiaojuan Zhou, and
Guodong
Li.
477. September 15, 2003), Department of Biology and Biochemistry,
Northeastern University, Boston, MA, invited seminar: Approaches for Improved Assays
for Prion Proteins in Simple Biofluids.
478. Central New England Chromatography Council Meeting, November 11,
2003, Burlington, MA, invited talk: Approaches for Improved Assays for Prion
Proteins in Simple Biofluids.
479. November 18-21, 2003, USP Biological and Biotechnology Conference,
Crystal City, VA, invited lecture: Characterization of human, monoclonal
antibodies by CIEX, cIEF, and MS methods (I.S. Krull)
2004 Scientific Presentations of Prof. Krull’s Research Group
480. NPR Radio Show Interview, Monday, January 26, 2004, Prions and Mad
Cow Disease, hosted by Debra Dawson, 1-hour, streamed across the Internet.
481. The Pittsburgh Conference, Chicago, IL, March 7-12, 2004, two poster
papers presented: 1) S. Schiavo, W.-C. Yang, N.H. Chiu, and I.S. Krull.
Comparison of different detection methods for quantitative polymerase chain reaction
(PCR); 2) Y. Wang, X. Zhou, G. Li, N.H. Chiu, and I.S. Krull. Affinity
capillary electrophoretic determination of binding constants of different antibodies
against the prion protein.
482. McGill University, Department of Chemistry, Montreal, Quebec, Canada,
invited lecture, March 26, 2004. Newer assays for PrPres in simple biofluids,
antemortem. Concordia University, Department of Chemistry, Montreal, Quebec,
Canada, external examiner, Ph.D. Thesis Defense for Dr. Dirk Bandilla, March
26, 2004.
483. Åpril 5, 2004, invited presentation, Idexx Laboratories, Westborough,
ME, Newer assays for PrPres in simple biofluids, antemortem.
484. May 11, 2004. Central New England Chromatography Council, 6th
Symposium on Advances in Separation Science and Mass Spectrometry, Northeastern
University, Boston, MA, poster paper: K. Millea, A. Chakraborty, D. Wall, S.A.
Cohen, I.S. Krull, and S.J. Berger. Combining to-down/bottom-up proteomic
approaches using multidimensional LC/MS and LC/MS/MS for the analysis of complex
protein mixtures.
485. May 12-13, 2004, Training Course at Shire Pharmaceuticals,
Northborough, MA, 2-day course on Analytical Methods Development, Optimization,
and
Validation (with MES) (arranged by Uditha DeAlwys)
486. American Society for Mass Spectrometry (ASMS), National Meeting,
Nashville, TN, May 23-27, 2004, submitted poster paper: A multidimensional intact
protein LC/MS workflow for the analysis of complicated proteomic mixtures,
K.M. Millea, D. Wall, A. Chakraborty, S.A. Cohen, I.S. Krull, and S.J. Berger.
487. HPLC 2004, Philadelphia, PA, June 12-18, 2004, 1/2-day short courses
(2), Analytical Method Development and Validation (with M.E. Swartz), invited
courses. Poster paper presented: Multidimensional LC/MS approaches for the
analysis of proteins in biofluids K. Millea, A. Chakraborthy, S.A. Cohen, I.S.
Krull, and S.J. Berger.
488. August 17-18, 2004, Training Course at Amgen Pharmaceuticals,
Boulder, CO, 2-day course on Analytical Methods Development, Optimization, and
Validation (with MES).
489. October 18-19, 2004, Frederick Conference on Capillary
Electrophoresis, Frederick, MD, paper submitted: Nonaqueous capillary gel
electrophoresis
for analysis of synthetic organic polymers and oligomers (I.S. Krull, X. Zhou,
G. Li, N. Grinberg, K. Mistry, and H. Cortes).
490. November 16, 2004, Eastern Analytical Symposium, Middlesex, NJ,
invited lecture in Separations Award Symposium for John Dorsey: Nonaqueous
capillary gel electrophoresis for analysis of synthetic organic polymers and
oligomers (I.S. Krull, X. Zhou, G. Li, N. Grinberg, K. Mistry, and H. Cortes).
491. November 11, 2004, Pfizer Corporation, R&D Department, Groton, CT,
invited lecture: Application of laser light scattering methods combined with
HPLC/SEC for the characterization of recombinant
antibodies (I.S. Krull).
492. November 23, 2004, Boston University School of Medicine, Mass Spec
Resource Center, invited talk: Modern methods for the characterization of
recombinant, monoclonal antibodies.
2005 Scientific Presentations of Prof. Krull’s Research Group
493. February 6, 2005, ABRF Meeting, The Association of Biomolecular
Resource Facilities, Poster Paper, K. Millea, I.J. Kass, J.C. Gebler, I.S. Krull,
and S.J. Berger. Evaluating Multidimensional Liquid Chromatographic Separations
of Complicated Protein Mixtures. In Poster Session on: Evaluating
Multidimensional Liquid Chromatographic Separations of Complicated Protein Mixtures,
Savannah, GA.
494. May 10, 2005, CNECC Symposium at Northeastern University. Poster
paper presented: Evaluating Multidimensional LC/MS Separations of Complicated
Protein Mixtures. Kevin Millea; Asish Chakraborty; Steven A. Cohen; Ira S. Krull;
and Scott J. Berger.
495. June 3, 2005, New York University, Department of Chemistry, Professor
D.I. Schuster Retirement Symposium, invited lecture, Modern methods for the
characterization of recombinant, monoclonal antibodies and glycoproteins. I.S.
Krull.
496. June 10, 2005, MedImmune Corporation, Analytical Biochemistry
Department, Gaithersburg, MD, invited lecture: Characterization of an unknown
derivative in transgenic human monoclonal tissue necrosis factor-alpha antibody. I.S.
Krull
497. July, 2005, New York State, Institute for Biomedical Research, Staten
Island, NYC, invited lecture, Affinity capillary electrophoresis for the
determination of binding constants of antibodies to antigenic proteins and related
antigens. I.S. Krull
498. July 13-14, 2005, Teva Pharmaceuticals, Ltd., Netanya, Israel,
invited lectures/seminar. Methods for the complete characterization of proteins and
related materials. I.S. Krull
499. September, 2005, American Chemical Society, Fall National Meeting,
Philadelphia, PA. Characterization of a multidimensional (IEX/RP) protein
separation at the component level. Kevin Millea, Ira S. Krull, John C. Gebler, and
Scott J. Berger.
500. October 6-7, 2005, Purdue University and Bioanalytical Systems, West
Lafayette, IN, invited talk, Modern methods for the characterization of
recombinant, monoclonal antibodies and glycoproteins. I.S. Krull
501. October 17-18, 2005. Frederick Conference on CE and Proteomics,
Frederick Cancer Research Center, Frederick, MD. Oral presentation:
Multidimensional HPLC-MS for improved proteomics measurements. I.S. Krull.