Lesson Plan Wednesday February 25th, 2004
TLW learn an overview of metabolism and the major pathways
Activity 1: Five students will arrange themselves in the starch to glucose pathway
Discuss that this is an example of a metabolic pathway – series of enzyme-catalyzed
reactions
Each product can also be a substrate for another enzyme
Activity 2: add sucrose and sucrase
Have students work out that pathways can merge
Then can also branch if two enzymes can use the same substrate
Metabolism – sum of all enzyme-catalyzed reactions in body
Anabolism – reactions that build bigger molecules from smaller, use energy
Catabolism – reactions that break down big molecules into smaller ones to get energy
Show Sigma Chart of Metabolic Pathways
Ask students what they notice about the chart
Hopefully notice color coding – represents different pathways
Notice glucose/glycolysis in middle – central pathway, probably most ancient
All pathways eventually are interconnected – branch and merge/converge
Read off pathway titles, ask students to classify them as anabolic or catabolic
Have one “anabolic” and one “catabolic” student write them on board
Adjust list below to reflect chart
Anabolic
Amino acid synthesis
Lipid synthesis
Hormone synthesis
Photosynthesis
Gluconeogenesis
Catabolic
Glycolysis
Citric Acid cycle
Electron transport chain
lipolysis
amino acid degradation
Lesson Plan Thursday 25th, 2004
TLW will connect metabolic pathways and identify the connecting chemicals - the
products of one pathway that are the substrates for the next
Activity: Give the students paper cutouts representing the major pathways and blanks to
fill in the connecting chemicals
Show/hang the chart
Let students arrange pathways, using the chart for reference, ask them to fill in the
connecting chemicals
Students should have trouble linking CAC and ETC, others
Point out that they are not linked by carbon-based chemicals (building blocks) but instead
are linked by energy molecules
Lecture Presentation
ATP – adenosine triphosphate – show carton segueing into chemical structure on PPT
Vs. ADP
Identify adenine and ribose – have them write the chemical formula for ribose
Talk about high energy bond, how many calories are in the bond
NADH/NADPH – electron carriers
Oxidized – lost electrons, lost energy
Reduced – gained electrons, gained energy
On PPT
NAD+ is oxidized, so has __________ energy
NADH is reduced, so has __________ energy
NADP+ is __________, so has __________ energy
NADPH is __________, so has __________ energy
Activity 2: Finish connecting pathways using ATP and NADH
Ask – what happens if one pathway uses up all the ATP or NADH?
Others can’t work – all must be regulated/share
Why taking extra of one chemical doesn’t always help
Assign students to write down three non-plant supplements in health food section of store
and come look them up to se which pathway they are supposed to be boosting