ABBREVIATED CURRICULUM VITAE - Universidad Complutense

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ABBREVIATED CURRICULUM VITAE (8/2012)
Personal Data
José R. Regueiro
Present position
Permanent address
Born on July 8, 1958 in Santiago (La Coruña)
Full Professor of Immunology
Inmunología, Facultad de Medicina
Universidad Complutense
28040 Madrid, SPAIN, Tel +34913941642
e-mail: [email protected]
Education
1980. MSc. Biochemistry and Genetics. Universidad Complutense. Madrid.
Languages: English (fluently), French (conversation), German (translation).
1981-84. HLA in reproduction and in disease susceptibility. Complement
immunogenetics. Dept. of Immunology (Prof. A. Arnaiz). Hosp. Ramón y Cajal.
1981. Complement allotyping. Centre de Transfusion Sanguine (Dr. G. Hauptman).
Strassbourg. France.
1982. MSc. Complement allotyping. Universidad Complutense. Madrid.
1984. Molecular Biology. Centre Hayem (Dr. D. Cohen, Prof. J. Dausset). Hôpital St.
Louis. France.
1985. ScD, PhD in Immunology. Universidad Complutense. Madrid.
1984-86. Immunodeficiencies. Dept. of Immunology (Prof. A. Arnaiz-Villena).
Hospital 12 de Octubre. Madrid.
2004. Ministry of Education/Health-certified Immunologist.
2006-7. SLAM family. Div. of Immunology (Prof. Cox Terhorst). Beth Israel
Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
2008. Aneca-certified for Full Professor http://www.aneca.es/
Positions
1986. Head, Cellular and Humoral Immunology Laboratory. Dept. of Immunology
(Dr. A. Arnaiz-Villena), Hospital 12 de Octubre, Madrid.
1989. Associate Professor of Immunology, School of Medicine, University of
Valladolid. Board: Martínez-A C, López de Castro JA, Poljack R, Stutman O,
Coutinho A, Rubinstein P, Palacios R, Parkhaus M.
1993. Associate Professor of Immunology, School of Medicine, Universidad
Complutense, Madrid.
1995. Head, Center of Immunological Techniques. Universidad Complutense. Madrid
2007. Coordinator, Joint Immunology PhD Program of the three main public
Universities in Madrid http://www.ucm.es/info/inmuno/doctorado.htm
2009. Coordinator, Joint Master in Immunology Program of the three main public
Universities in Madrid http://www.ucm.es/info/inmuno/master.htm
2012. Head, Dept. of Microbiology, School of Medicine, Universidad Complutense,
Madrid.
RESEARCH INTERESTS
T lymphocyte physiopathology, congenital immunodeficiencies, gene therapy
BOOKS
Regueiro JR, López-Larrea C, González S, Martínez-Naves E. Inmunología: biología y
patología del sistema inmunitario. Editorial Médica Panamericana, Madrid. 4th ed with
website (2010): http://www.medicapanamericana.com/inmunologia/regueiro/inicio.asp
SELECTED PUBLICATIONS (out of 76 in PubMed)
•Muñoz-Ruiz M, Regueiro JR. New tools in regenerative medicine: gene therapy. Adv
Exp Med Biol. 741: 254-75 (2012).
•Gil J, Busto EM, Garcillán B, Chean C, García-Rodríguez MC, Díaz-Alderete A,
Navarro J, Reiné J, Mencía A, Gurbindo D, Beléndez C, Gordillo I, Duchniewicz M,
Höhne K, García-Sánchez F, Fernández-Cruz E, López-Granados E, Schamel WWA,
Moreno-Pelayo MA, Recio MJ, Regueiro JR. A leaky mutation in CD3D differentially
affects ab and gd T cells and leads to a Tab─Tgd+ B+NK+ human SCID. J Clin
Invest 121:3872-6 (2011).
•Reiné J, Busto EM, Muñoz-Ruiz M, Rossi NE, Rodríguez-Fernandez JL, MartínezNaves E, Regueiro JR/Recio MJ. CD3g-independent pathways in TCR-mediated
signaling in mature T and iNKT lymphocytes. Cell Immunol 271:62-6 (2011)
•Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando
D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Celine Hanson I, Grunebaum
E, Shearer WT, Roifman CM. Hematopoietic stem cell transplantation for CD3d
deficiency. J Allergy Clin Immunol 128:1050-7 (2011)
•Berger SB, Romero X, Faubion WA, Compeer E, Liao G, Laroux S, Keszei M, Rameh L,
Wang N, Boes M, Regueiro JR, Terhorst C. The co-stimulatory molecule SLAM
regulates killing of Gram-negative bacteria by macrophages through
phosphatidylinositol-3-phosphate production in phagosomes. Nat Immunol 11: 920–927
(2010).
•Liao G, Nayak S, Regueiro JR, Berger SB, Detre C, Romero X, de Waal Malefyt R,
Chatila TA, Herzog RW, Terhorst C. GITR engagement preferentially enhances
proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int
Immunol. 22:259-70 (2010).
•Gozalbo-López B, Gómez del Moral M, Campos-Martín Y, Setién F, Martín P, Bellas
C, Regueiro JR, Martínez-Naves E. The MHC-related protein 1 (MR1) is expressed by
a subpopulation of CD38+IgA+ cells in the human intestinal mucosa. Histol
Histopathol. 24:1439-49 (2009).
•Rossi NE, Reiné J, Pineda-Lezamit M, Pulgar M, Meza NW, Swamy M, Risueno R,
Schamel WW, Bonay P, Fernández-Malavé E, Regueiro JR. Differential antibody
binding to the surface alphabetaTCR•CD3 complex of CD4+ and CD8+ T
lymphocytes is conserved in mammals and associated with differential glycosylation.
Int Immunol. 20:1247-1258 (2008).
•Recio MJ, Moreno-Pelayo MA, Kilic SS, Guardo AC, Sanal O, Allende LM, PerezFlores V, Mencia A, Modamio-Hoybjor S, Seoane E, Regueiro JR. Differential
biological role of CD3 chains revealed by human immunodeficiencies. J Immunol
178: 2556-64 (2007).
•Siegers GM, Swamy M, Fernandez-Malave E, Minguet S, Rathmann S, Guardo AC,
Perez-Flores V, Regueiro JR, Alarcon B, Fisch P, Schamel WW. Different
composition of the human and the mouse gd T cell receptor explains different
phenotypes of CD3g and CD3d immunodeficiencies. J Exp Med 204: 2537-44
(2007).
•Martín-Fernández JM, Cabanillas JA, Rivero M, Lacasa E, Pardo J, Anel A,
Rodríguez-Duque PR, Merino F, Rodríguez-Gallego C, Regueiro JR. Herpesvirus
saimiri-transformed CD8+ T cells as a tool to study Chediak-Higashi syndrome
cytolytic lymphocytes. J Leukoc Biol 77:661-8 (2005).
•Zapata DA, Schamel WW, Torres PS, Alarcon B, Rossi NE, Navarro MN, Toribio ML,
Regueiro JR. Biochemical differences in the alphabeta T cell receptor.CD3 surface
complex between CD8+ and CD4+ human mature T lymphocytes. J Biol Chem. 279:
24485-92 (2004).
•TCR dynamics in human mature T lymphocytes lacking CD3g. Torres PS, Alcover A,
Zapata DA, Arnaud J, Pacheco A, Martín-Fernández JM, Villasevil EM, Sanal O,
Regueiro JR. J Immunol 170: 5947-55 (2003).
•Pacheco-Castro A, Martin JM, Millan R, Sanal O Allende L, Regueiro JR. Toward
gene therapy for human CD3 deficiencies. Hum Gene Therapy 14:1653-61 (2003).
•Characterization of Herpesvirus saimiri-Transformed T Lymphocytes from Common
Variable Immunodeficiency Patients. Cabanillas JA, Cambronero R, Pacheco A,
García Rodríguez MC, Martín Fernández JM, Fontán G, Regueiro JR. Clin Exp
Immunol 127: 366-373 (2002).
•Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human
CD4+ and CD8+ T lymphocytes is ATM-independent. Rivero-Carmena M, Porras O,
Pelaez B, Pacheco A, Gatti RA, Regueiro JR. Int Immunol 12: 927-935 (2000).
•Conformational and biochemical differences in the TCR.CD3 complex of CD8+ versus
CD4+ mature lymphocytes revealed in the absence of CD3g. Zapata DA, PachecoCastro A, Torres PS, Ramiro AR, San José E, Alarcon B, Alibaud L, Rubin B, Toribio
ML and Regueiro JR. J Biol Chem 274:35119-35128 (1999).
•Signaling through a CD3g-deficient TCR/CD3 complex in immortalized mature CD4+
and CD8+ T lymphocytes. Pacheco-Castro A, Alvárez-Zapata D, Serrano-Torres P
and Regueiro JR. J Immunol 161:3152-3160 (1998)
•Construction of retroviral vectors carrying human CD3g cDNA and reconstitution of
CD3g expression and T cell receptor surface expression and function in a CD3gdeficient mutant T cell line Sun J, Pacheco-Castro A, Borroto A, Alarcón B, AlvárezZapata D and Regueiro JR. Hum Gene Therapy 8: 1041-1048 (1997)
•T-lymphocyte receptor deficiencies. Kappes D, Alarcón B, Regueiro JR. Curr Opin
Immunol 7, 441-447 (1995)
•Primary immunodeficiency caused by mutations in the CD3g subunit of the Tlymphocyte receptor. Arnaiz-Villena A, Timón M, Corell, Pérez-Aciego P, MartínVilla JM, Regueiro JR. New Eng J Med 327, 529-533 (1992)
•Human T-cell activation deficiencies. Arnaiz-Villena A, Timón M, Rodríguez-Gallego
C, Pérez-Blas M, Corell A, Martín-Villa JM, Regueiro JR. Immunology Today 13,
259-265 (1992)
•Expression and function of a variant T-cell receptor complex lacking CD3g. PérezAciego P, Alarcón B, Arnaiz-Villena A, Terhorst C, Timón M, Segurado O, Regueiro
JR. J Exp Med 174, 319-326 (1991)
•Biochemical basis of a novel T-lymphocyte receptor immunodeficiency by
immunohistochemistry: a possible CD3g abnormality. Arnaiz-Villena A., PerezAciego P, Ballestín C, Sotelo T, Perez-Seoane C, Martin-Villa JM, Regueiro JR. Lab
Invest 64, 675-681 (1991)
•Familial defect in the surface expression of the T-cell receptor/CD3 complex. Alarcon
B, Regueiro JR, Arnaiz A, Terhorst C. N Eng J Med 319, 1203-1208 (1988)
•Familial defect of CD3 (T3) expression by T cells associated with rare gut epithelial
cell autoantibodies. Regueiro JR, Arnaiz-Villena A, O de Landazuri M, Martin-Villa
JM, Vicario JL, Pascual-Ruiz V, Guerra-Garcia F, Alcamí J, Lopez-Botet M,
Manzanares J. Lancet 1, 1274-5 (1986)
•HLA factors in non-insulin-dependent diabetes mellitus. Arnaiz-Villena A, Rodriguez
Cordoba S, Regueiro JR, Bootello A, Serrano-Rios M. N Eng J Med 303,1065 (1980)
•Immunofixation for C2 typing: C2 allotypes in Spaniards in relation to HLA, Bf and
C4. Regueiro JR, Arnaiz-Villena A. Hum Genet 71, 58-61 (1985)
TRAINING OF POSTDOCS
Name (degree) Years as postdoc, Present position (2010).
Mª José Recio (PhD) 2005-2007, Assistant Professor, Immunology Dpt, School of
Medicine, Univ. Complutense, Madrid
Eduardo López Granados (MD) 2004-5, Head, Immunology Dpt, Hospital La Paz
Pilar Serrano Torres (PhD) 2002-2003, Clinical Research Associate, Parexel, Madrid,
David Álvarez Zapata (PhD) 1999-2003, Clin. Res. Manager, TFS Trial Form Support,
Madrid
Alberto Pacheco Castro (PhD) 1997-2002, Assist. Prof. Univ. Alfonso X El Sabio, Head
Andrology Lab., Inst. Valenciano de Infertilidad, Madrid
Joel Yao Sun (MD) 1995-1996, Clinical Laboratory Scientist, Supervisor, Berkeley
HeartLab, Celera Co., San Francisco, CA, USA
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