何元順教授學經歷及學術貢獻
中文學經簡歷:
1987 台北醫學大學 醫學院 醫技學系 學士
1989 國立台灣大學醫學院 生化碩士 (肄業 直攻博士)
1990 國立台灣大學醫學院生化博士
1994 國立台灣大學醫學院生化 博士後研究
1995 台北醫學大學 醫學院 醫技學系 副教授
2000 台北醫學大學 醫學院 醫技學系 教授
2001 台北醫學大學 醫學院 醫技學系 教授兼任系主任
2001 台北醫學大學 醫學院 醫技學系 教授兼任所長
2005-台北醫學大學 醫學院 醫技學系 教授
研究成果說明:
(一)、研究緣起:
乳癌與肝癌分別是國人女性與男性發生率最高的癌症，由於其極度惡性化、不容易治療、而且有轉移(metastasis)的傾
向，其發生機率和死亡率正逐年增加。因為台灣地區最近的研究發現乳癌與肝癌的發生與環境中藥物殘存，電磁波，荷
爾蒙(避孕藥)或藥物濫用等因子有密切關係。另外，針對國人個體差異所作的分析證實 1.遺傳基因多樣化特性，2.血液
或癌組織中微量元素改變，3.致癌或抗癌基因表現表現異常，4. 肥胖等因子與乳癌或肝癌發生率相關。然而，最重要的
是乳癌發生與抽菸習性或接觸二手煙是否有關，並未獲得直接的證實。
(二)、組織研究團隊:
候選人何元順教授近年來潛心於抽菸誘發乳癌之分子機制之研究，另外何教授與食品學專家學者合作，尋找有潛力之抗
癌或防癌之保健食品，希望在努力探討致癌作用之餘，也能在防癌作用有所突破。因此何教授積極與臨床醫師諮詢並取
得臨床檢體，希望以轉譯醫學之研究成果應用於臨床。本項研究與台北醫學大學外科學科吳志雄教授(現任雙和醫院院
長，專長為腸胃外科)，國泰醫學中心黃清水教授/院長(專長為肝膽外科)，台北醫學大學附設醫院陳清祥主任(專長為乳
房外科)，國泰醫學中心杜世興主任(專長為乳房外科)。主要研究人力包括台北醫學大學醫科所博士生李嘉華同學，及實
驗室所有研究人力。
(三)、形成研究共識:---癌細胞表面受體分子之致癌與防癌機制研究
1.何教授近年潛心於探究國人抽菸習性與乳癌發生之直接分子證據，研究對象為針對 276 例國人乳癌病人採樣，所有病
人均取得癌組織與周邊正常組織作為對照。針對這些檢體分析其組織中尼古丁受體的表現與不同分期癌組織中的表現
量。利用細胞，動物，與人體組織研究數據證實乳癌細胞中特定之尼古丁受體(9-nAChR)可以直接與香菸中的尼古丁結
合，導致正常乳房上皮細胞癌化並增生成為腫瘤。
2.何教授發現肝癌細胞中葡萄糖轉換受體高度表現，何教授針對此一轉換受體在蘋果多酚找到天然抑制劑(Phloretin)，
並以動物實驗之正子(micro-PET)掃描分析證實 Phloretin 可抑制葡萄糖進入肝癌細胞，進而誘發肝癌細胞凋亡，得到顯
著的抗癌成果。
(四)、具體研究成果:
研究主題一: 尼古丁受體參與與抽菸誘發乳癌形成之致癌機制研究。
此部分報告已被 Journal of The National Cancer Institute, (JNCI)雜誌所接受，預計於 2010 年 9 月 8 日出刊。
研究主題二: 天然物拮抗或預防尼古丁受體參與與抽菸誘發乳癌形成之機制研究。
此部分結果分別發表於 Breast Canc Res & Treat (2010), Journal of Agri Food Chem (2010), Mol Nutr & Food Res (2010)
研究主題三: 蘋果多酚抑制第二型葡萄糖轉運體(type-2 glucose transporter)作為肝癌抗癌研究之分子標的可行性探討。
此部分結果分別發表於 Int J Cancer (2010), Mol Carcinogen (2009)
五、論文著述：
（一）請詳列個人最近五年內發表之學術性著作，包括：期刊論文、專書及專書論文、研討會論文、
技術報告及其他等，並請依各類著作之重要性自行排列先後順序。
（二）各類著作請按發表時間先後順序填寫。各項著作請依作者姓名（按原出版之次序）、出版年、
月份、題目、期刊名稱（專書出版社）
、起迄頁數之順序填寫，被接受刊登尚未正式出版者請
附被接受函。
（三）若期刊屬於 SCI、EI、SSCI 或 A&HCI 等時，請註明；若著作係經由國科會補助之研究計畫所
產生，請於最後填入相關之國科會計畫編號。
1、 研究論文 (Original paper)
2010
1. Chia-Hwa Lee, Ching-Shui Huang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Yu-Jia, Chang,
Ka-Wai Tam, Po-Li Wei, Tzu-Chun Cheng, Jan-Show Chu, Li-Ching Chen, Chih-Hsiung Wu and
Yuan-Soon Ho (corresponder) (2010) Overexpression and Activation of the 9-Nicotinic Receptor
during Tumorigenesis in Human Breast Epithelial Cells. Journal of the National Cancer Institute 102
(17): 1322 – 1335. （SCI：impact factor 14.069, Oncology field：6/165; 3.6%）.
2. Shih-Hsin Tu, Chung-Yu Ku, Chi-Tang Ho, Ching-Shyang Chen, Ching-Shui Huang, Chia-Hwa Lee,
Li-Ching Chen, Min-Hsiung Pan, Hui-Wen Chang, Chien-Hsi Chang, Yu-Jia, Chang, Po-Li Wei,
Chih-Hsiung Wu and Yuan-Soon Ho Yuan-Soon Ho
(corresponder) (2010)Tea polyphenol
(-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced 9-nicotinic acetylcholine receptor
upregulation in human breast cancer cells Molecular Nutrition & Food Research (accepted) 2010
(SCI：impact factor 4.356,Food Science & Technology field：1/118; 0.8 %)
3. Ching-Shyang Chen, Chang-Da Hsieh, Chia-Hwa Lee, Chi-Tang Ho, Min-Hsiung Pan, Ching-Shui
Huang, Shih-Hsin Tu, Ying-Jan Wang, Chih-Hsiung, Wu, and Yuan-Soon Ho (corresponder) (2010).
Nicotine-induced human breast cancer cell proliferation is attenuated by garcinol through
down-regulation of nicotinic receptor and cyclin D3 proteins. Breast Cancer Research and Treatment.(in
press):-. （SCI：impact factor 4.696, Oncology field：30/165; 18.2%）
4. Shih-Hsin Tu, Chih-Chiang Chang, Ching-Shyang Chen, Ka-Wai Tam, Ying-Jan Wang, Chia-Hwa Lee,
Hsiao-Wei Lin, Tzu-Chun Cheng, Ching-Shui Huang, Jan-Show Chu, Neng-Yao Shih, Li-Ching Chen,
Sy-Jye Leu, Yuan-Soon Ho (corresponder) and Chih-Hsiung Wu* (2010). Increased expression of
enolase  in human breast cancer confers tamoxifen resistance in human breast cancer cells. Breast
Cancer Research and Treatment 121:539-553. （SCI：impact factor 4.696, Oncology field：30/165;
18.2%）
5. Ching-Shui Huang, Yi-Ru Lee, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Chia-Hwa Lee,
Li-Ching Chen, Hui-Wen Chang, Chien-Hsi Chang, Chih-Hsiung Wu and Yuan-Soon Ho
(corresponder) (2010). Long-term ethanol exposure causes human liver cancer cells to be resistant to
mitomycin C treatment through inactivation of Bad-mediated apoptosis. Molecular
Carcinogenesis.(acepted):-. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
6. Yung-Leun Shih, Hui-Ching Liu, Ching-Shyang Chen, Chung-Huei Hsu, Min-Hsiung Pan, Hui-Wen
Chang, Chien-Hsi Chang, and Yuan-Soon Ho (corresponder) (2010). Combination treatment with
luteolin and quercetin enhances anti-proliferative effects in nicotine-treated MDA-MB-231 cells by
downregulating nicotinic acetylcholine receptors. Journaql of Agriculture Food Chemistry.(58):235-241.
（SCI：impact factor 2.469, Agriculture, Multidisciplinary field：2/44; 4.5%）
7. Chen, R. J., Ho, Y. S, Guo, H. R., Wang, Y. J.(2010). Long-term nicotine exposure-induced
chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and
beta-adrenoceptors in human bladder cancer cells. Toxicological Science. (115):118-130. （SCI：impact
factor 4.814,Toxicology field：4/77; 5.2 %）
2009
8. Chang, M. C., Chan, C. P., Ho, Y. S., Lee, J. J., Lin, P. S., Jeng, J. H.(2009). Signaling pathways for
induction of platelet aggregation by SAS tongue cancer cells--a mechanism of hematogenous
metastasis. J Oral Pathol Med.():-.
9. Hsu, S. P., Ho, P. Y., Liang, Y. C., Ho, Y. S., Lee, W. S(2009). Involvement of the JNK activation in
terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial
cells. J Cell Biochem.(108):860-866.
10. Wang, X., Ni, J., Hsu, C. L., Johnykutty, S., Tang, P., Ho, Y. S., Lee, C. H., Yeh, S(2009). Reduced
expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer. Cancer
Invest.(27):971-977.
11. Hsiu-Man Lien, Hsiao-Wei Lin, Ying-Jan Wang, Li-Ching Chen, Ding-Yah Yang, Ya-Yun Lai*, and
Yuan-Soon Ho (corresponder). Inhibition of anchorage-independent proliferation and G0/G1 cell
cycle regulation in human colorectal carcinoma cells by 4,7-dimethoxy-5-methyl-l,3-benzodioxole
isolated from the fruiting body of Antrodia camphorate. (2009) Evidence Based Complicated
Alternative Medicine (In press). （SCI：impact factor 2.064, INTEGRATIVE & COMPLEMENTARY
MEDICINE field：3/17; 17.6%）
12. Chih-Hsiung Wu, Yuan-Soon Ho*(equal contribution), Chia-Yi Tsai, Ying-Jan Wang, How Tseng,
Po-Li Wei, Chia-Hwa Lee, Ren-Shen Liu, Shyr-Yi Lin(2009). In vitro and in vitro study of
phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose
transporter. International Journal of Cancer.(124): 2210–2219. （SCI：impact factor 4.722, Oncology
field：29/165; 17.6%）
13. Yuan-Soon Ho, Ming-Tang Lai, Sin-Ju Liu, Cher-Tang Lin, Naruishi K, Takashiba S, Hsin-Hua Chou
(2009). Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of
Gp130 in endothelial cells. Journal Periodont Research. 44: 550–556. （SCI：impact factor ,1.966,
DENTISTRY, ORAL SURGERY & MEDICINE field：18/64; 28.1%）
14. Kuo-Ching Yang, Chia-Yi Tsai, Ying-Jan Wang, Po-Li Wei, Chia-Hwa Lee, Jui-Hao Chen,
Chih-Hsiung Wu*, and Yuan-Soon Ho (corresponder)*(2009). Apple polyphenol phloretin
potentiates the anticancer actions of paclitaxel through induction of apoptosis in human Hep G2 cells.
Molecular Carcinogenesis.(48):420–431). (SCI：impact factor 3.202, Oncology field： 59/165;
35.8% )
15. Po-Li Wei, Yu-Jia Chang, Yuan-Soon Ho, Chia-Hwa Lee, Yi-Yuan Yang, Jane An, and Shyr-Yi Lin,
(2009) Tobacco-specific carcinogen enhances colon cancer cell migration through 7-nicotinic
acetylcholine receptor. Annals of Surgery. 249:978-985. （SCI：impact factor 7.9, Surgery field：1/166;
0.6%）
16. Li-Ching Chen, Yu-Chi Liu, Yu-Chih Liang, Yuan-Soon Ho, and Wen-Sen Lee (2009) Magnolol
inhibits human glioblastoma cell oroliferation through upregulation of p21/Cip1. Journal of Agriculture
Food Chemistry (in press). （SCI：impact factor 2.469, Agriculture, Multidisciplinary field：2/44;
4.5%）
17. Ting-Kai Leung, Chi-Ming Lee, Ming-Yu Lin, Yuan-Soon Ho, Ching-Shyang Chen, Chih-Hsiung Wu,
and Yung-Sheng Lin. (2009) Far infrared ray irradiation induces intracellular generation of nitric oxide
in breast cancer cells. Journal of Medical and Biological Engineering 29(1): 15-18.
2008
18. Xi Wang, Jing Ni, Chen-Long Hsu, Sharlin Johnykutty, Ping Tang, Yuan-Soon Ho, Chia-Hwa Lee,and
Shuyuang Yeh(2008). Reduced Expression of Tocopherol-Associated Protein (TAP/Sec14L2) in
Human Breast Cancer. Cancer Investigation.(In press):-.
19. Ho, Pei-Yin, Hsu Sung-Po, Liang, Yu-Chih, Kuo, Min-Liang, Yuan-Soon, Ho, Lee,
Wen-Sen(2008).Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21
up-regulation and DNA synthesis inhibition in human vascular endothelial cells. Toxicology and
Applied Pharmacology.(229):86-93.
20. Mei-Chi Chang,Chiu-Po Chan, Yuan-Soon Ho, Jang-Jaer- Lee, Po-Shuen Lin, Bor-Ru Lin, Ya-Ling
Huang, Liang-Jiunn Hahn, Hung-(2008).Induction of platelet aggregation by SAS tongue cancer cells:
a mechanism of hematogenous metastasis. Journal of Oral Pathology and Medicine.(In press):-.
21. Ching-Shyang Chen, Chih-Hsiung Wu, Yen-Chun Lai, Wen-Sen Lee, Hsiu-Min Chen, Rong-Jane Chen,
Li-Ching Chen, Yuan-Soon Ho (corresponder), and Ying-Jan Wang. NF-κB-activated tissue
transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in
preventing fibrogenesis Toxicology (246):148-157. (SCI：impact factor 2.919, Toxicology field：15/76;
19.74% )
22. Ching-Shui Huang, Wei-Lu Ho, Wen-Sen Lee, Ming-Thau Sheu, Ying-Jan Wang, Shih-Hsin Tu,
Rong-Jane Chen, Jan-Show Chu, Li-Ching Chen, Chia-Hwa Lee, How Tseng, Yuan-Soon Ho
(corresponder) and Chih-Hsiung Wu SP1-regulated p27/Kip1 gene expression is involved in
terbinafine-induced human A431 cancer cell differentiation: an in vitro and in vivo study Biochemical
Pharmacology 75:1783-1796, 2008.（SCI：impact factor 4.06,Pharmacology and pharmacy field：
45/199; 15.6%）
23. Rong-Jane Chen, Yuan-Soon Ho, How-Ran Guo, and Ying-Jan Wang. (2008) Rapid Activation of
Stat3 and ERK1/2 by Nicotine Modulates Cell Proliferation in Human Bladder Cancer Cells
Toxicological Science 104(2):283-293.（SCI：impact factor 4.43,Toxicology field：5/76; 6.7 %）
2007
24. Tain-Junn Cheng, Ying-Jan Wang, Wei-Wan Kao, Rong-Jane Chen, Yuan-Soon Ho (corresponder)
Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of
lipoic acid. Food and Chemical Toxicology 45:1027-1038, 2008 （SCI：impact factor 2.186, Food
Science and Technology field：14/103; 13.6%）
25. Yean-Hwei Chou, Yuan-Soon Ho (corresponder), Chi-Chen Wu, Chiah-Yang Chai, Soul-Chin Chen,
Chia-Hwa Lee, Pei-Shan Tsai, and Chih-Hsiung Wu. Tubulozole-induced G2/M cell cycle arrest in
human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and
Chk1 kinase activation. Food and Chemical Toxicology 45:1356-1367 （SCI：impact factor 2.186,
Food Science and Technology field：14/103; 13.6%）
26. Yuan-Soon Ho. Ching-Shu Lai, Hsin-I Liu, Sheng-Yow Ho, Chein Tai, Min-Hsiung Pan, Ying-Jan
Wang. Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation
Biochemical Pharmacology 2007 (73):1786-1795. （SCI：impact factor 4.06,Pharmacology and
pharmacy field：45/199; 15.6%）
27. Yih-Huei Uen. Der-Zen Liu, Meng-Shih Weng, Yuan-Soon Ho (corresponder), and Shyr-Yi Lin5*
NF-kB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL60 cells J.
Cellular Biochemistry 2007 (101):1165-1175.
28. Meng-Shih Weng, Chi-Tang Ho, Yuan-Soon Ho and Jen-Kun Lin. Theanaphthoquinone inhibits fatty
acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of
EGFR/ErbB-2 signaling. Biochemical Pharmacology,218, 107-118, 2007. （ SCI ： impact factor
4.06,Pharmacology and pharmacy field：45/199; 15.6%）
29. Meng-Shih Weng. Yuan-Soon Ho and Jen-Kun Lin. Theanaphthoquinone inhibits fatty acid synthase
expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling
Toxicology and Applied Pharmacology 2007(218):107-118. （SCI：impact factor 3.846 ,Toxicology
field：6/73; 5.26%）
30. Jiunn-Chang Lin. Yuan-Soon Ho and Chih-Hsiung, Wu. Induction of apoptosis and cell-cycle arrest
in human colon cancer cells by meclizine Food and Chemical Toxicology 2007(45):935-944. (SCI：
impact factor 2.186, Food Science and Technology field：14/103; 13.6%）.
2006
31. Pei-Yin Ho, Wen-Bin Zhong, Yuan-Soon Ho, Wen-Sen Lee (2006). Terbinafine inhibits endothelial
cell migration through suppression of the Rho-mediated pathway. Molecular Cancer Therapeutic.
5(12):3130-3138. SCI：impact factor 5.137, Oncologyfield：22/127; 17.32%）
32. Jiunn-Chang Lin, Yuan-Soon Ho, Jie-Jen Lee, Chien-Liang Liu, Tsen-Long Yang, Chih-Hsiung Wu
(2006) Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. Food and
Chemical Toxicology 45(6):935-944. （SCI：impact factor 2.186, Food Science and Technology field：
14/103; 13.6%）
33. Yih-Huei Uen, Der-Zen Liu, Meng-Shih Weng, Yuan-Soon Ho (corresponder), Shyr-Yi Lin, (2006)
NF-B pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL60 cells J.
Cellular Biochemistry (SCI：impact factor 3,409, Biochemistry and molecular biology field：90/262;
34.35%) .
34. Yuan-Soon Ho, Ching-Shu Lai, Hsin-I Liu, Sheng-Yow Ho, Chein Tai, Min-Hsiung Pan and Ying-Jan
Wang (2006) Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and
anti-oxidation. Biochemical Pharmacology 73(11):1786-1795. (SCI：impact factor 4.06,Pharmacology
and pharmacy field：45/199; 15.6%）
35. Jinn-Shiun Chen, Shyr-Yi Lin, Wei-Ling Tso, Geng-Chang Yeh, Wen-Sen Lee, How Tseng, Li-Ching
Chen, and Yuan-Soon Ho (corresponder) (2006) Checkpoint kinase 1-mediated phosphorylation of
Cdc25C and Bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell
cycle arrest and apoptosis. Molecular Carcinogenesis 45:461-468. (SCI： impact factor 3.202,
Oncology field： 59/165; 35.8% )
36. Jiiang-Huei Jeng, Wan-Hong Lan, Juo-Song Wang, Chiu-Po Chan, Yuan-Soon Ho, Po-Hsuen Lee, Mei
Wang1, Yi-Jane Chen and Mei-Chi Chang (2005) Signaling mechanism of thrombin-induced gingival
fibroblast-populated collagen gel contraction Br J Pharmacol 147:188-198. (SCI：impact factor 3.825,
Pharmacology and phamacy field：39/199; 19.6% )
37. Jiiang-Huei Jeng, Hui-Lin Wu, Bor-Ru Lin, Wan-Hong Lan, Hsiao-Hwa Chang, Yuan-Soon Ho,
Po-Hsuen Lee, Ying-Jan Wang, Juo-Song Wang, Yi-Jane Chen, Mei-Chi Chang∗Antiplatelet effect of
sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production. (2006)
Atherosclerosis (in press). (SCI：impact factor 3.811, Peripheral vascular disease field：12/52; 23.08% )
38. How-Ran Guo, Chia-Hsin Chen, Sheng-Yow Ho, Yuan-Soon Ho, Rong-Jane Chen, Ying-Jan Wang
(2006) Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells.
International Journal of Radioation Biology 82(2):97-109 (SCI：impact factor 1.312, Nuclear science
and technology field：3/32; 9.38% )
39. Po-Hsuen Lee, Mei-Chi Chang, Wen-Hui Chang, Tong-Mei Wang, Ying-Jen Wang, Liang-Jiunn Hahn,
Yuan-Soon Ho (corresponder), Chuan-Yu Linb, Jiiang-Huei Jeng (2006) Prolonged exposure to
arecoline arrested human KB epithelial cell growth: regulatory mechanisms of cell cycle and apoptosis
Toxicology 220:81-89. (SCI：impact factor 2.919, Toxicology field：15/76; 19.74% )
40. Yang Kuo-Ching, Chi-Chen Wu, Chih-Hsiung Wu, Chen Jur-Hao, Chien-Hwa Chu, Chien-Ho Chen,
Chou Yean-Hwei, Ying-Jan Wang, Wen-Sen Lee, How Tseng, Shyr-Yi Lin, Chia-Hwa Lee, and
Yuan-Soon Ho (corresponder) (2006) Involvement of proapoptotic Bcl-2 family members in
terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells Food and Chemical
Toxicology. 44:214-226 （SCI：impact factor 2.186, Food Science and Technology field：14/103;
13.6%）
2005
41. Yuan-Soon Ho, Chien-Ho Chen, Ying-Jan Wang, Richard G. Pestell , Chris Albanese, Rong-Jane Chen,
Mei-Chi Chang, Jiiang-Huei Jeng, Shyr-Yi Lin, Yu-Chih Liang, How Tseng, Wen-Sen Lee, Jen-Kun
Lin, Jan-Show Chu, Li-Ching Chen, Chia-Hwa Lee, Wei-Ling Tso, Yann-Chwen Lai, and Chih-Hsiung
Wu (2005) Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
induces cell proliferation in normal human bronchial epithelial cells through NF
cyclin D1 upregulation. Toxicology and Applied Pharmacology 180:22-35. （SCI：impact factor
3.846 ,Toxicology field：6/73; 5.26%）
42. Yuan-Soon Ho, Chih-Hsiung Wu, Hsiao-Min Chou, Ying-Jan Wang, How Tseng, Chien-Ho Chen,
Li-Ching Chen, Chia-Hwa Lee, Shyr-Yi Lin, (2005) Molecular mechanisms of econazole-induced
toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic
signaling pathways. Food and Chemical Toxicology. 40:1483-1495, 2005. （SCI：impact factor 2.186,
Food Science and Technology field：14/103; 13.6%）
43. Meng-Shih Weng , Yuan-Soon Ho, Jen-Kun Lin (2005) Chrysin induces G1 phase cell cycle arrest in
C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated
protein kinase Biochemical Pharmacology,69, 1815-1827, 2005. （ SCI ： impact factor
4.06,Pharmacology and pharmacy field：45/199; 15.6%）
44. Chiu-Po Chan, Yuan-Soon Ho, Ying-Jen Wang, Wan-Hong Lan, Lin-I Chen, Yi-Jane Chen, Bor-Ru
Lin, Mei-Chi Chang, Jiiang-Huei Jeng, (2005) Inhibition of cyclooxygenase activity, platelet
aggregation and thromboxane B2 production by two environmental toxicants: m-cresol and o-cresol.
Toxicology (208): 95-104. (SCI：impact factor 2.919, Toxicology field：15/76; 19.74% )
2004
45. Ho, P. Y. Liang, Y. C. Ho, Y. S. Chen, C. T. Lee, W. S. Inhibition of human vascular endothelial cells
proliferation by terbinafine. International Journal of Cnacer 106:125-137. （SCI：impact factor 4.722,
Oncology field：29/165; 17.6%）
46. Wu, C. H. Chen, H. L. Su, H. J. Lee, C. C. Shen, K. T. Ho, W. L. Ho, S. Y. Ho, Y. S. Wang, Y. J. The
topical application of 2,3,7,8-tetrachlorodibenzo-p-dioxin lacks skin tumor-promoting potency but
induces hepatic injury and tumor necrosis factor-alpha expression in ICR male mice. Food and
Chemical Toxicology. 2003. 41:621-629 （SCI：impact factor 2.186, Food Science and Technology
field：14/103; 13.6%）
2003
47. Jeng JH, Wang YJ, Chiang BL, Lee PH, Chan CP, Ho YS, Wang TM, Lee JJ, Hahn LJ, Chang, M. C.
(2003) Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2,
interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline.
Carcinogenesis 24(8):1301-1315, 2003（SCI：impact factor 5.366,Oncology field：18/127; 14.17%）
48. Liu JD, Lin SY, Ho YS, Pan S, Hung LF, Tsai SH, Lin JK and Liang YC (2003) Involvement of c-Jun
N-terminal kinase activation in 15-deoxy-D12,14-prostaglandin J2 and prostaglandin A1-induced
apoptosis in AGS gastric epithelial cells. Mol. Carcinogenesis, 37(1):16-24, (SCI：impact factor
2.743,oncology field52/132; 39.39% )
49. Wen-Sen Lee,, Rong-Jane Chen, Ying-Jan Wang, Jiiang-Huei Jeng, Yu-Chih Liang, Chien-Ho Chen,
Chien-Huang Lin, Jen-Kun Lin, Pei-Yin Ho, Jan-Show Chu, Wei-Lu Ho, Li-Ching Chen, and
Yuan-Soon Ho (Correspondence) (2003) In vitro and in vivo studies of the anti-cancer action of
terbinafine in human cancer cell lines. International Journal of Cnacer 106:125-137. （SCI：impact
factor 4.722, Oncology field：29/165; 17.6%）
50. Jean-Dean Liu, Ying-Jan Wang, Chien-Ho Chen, Cheng-Fei Yu, Li-Ching Chen, Jen-Kun Lin, Yu-Chih
Liang, Shyr-Yi Lin, and Yuan-Soon Ho (Correspondence), (2003) Molecular mechanisms of G0/G1
cell cycle arrest and apoptosis induced by terfenadine in human cancer cells. Molecular
Carcinogenesis. 37:39-50. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
51. Wen-Ching Chang, Jiiang-Huei Jeng, Chi-Chang Shieh, Yi-Chang Tsai, Yuan-Soon Ho, How-Ran
Guo, Hsin-I Liu, Ching-Chang Lee, Sheng-Yow Ho, and Ying-Jan Wang. (2003) Skin tumor-promoting
potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone
in CD-1 Mice. Molecular Carcinogenesis 36:161-170. (SCI：impact factor 3.202, Oncology field：
59/165; 35.8% ).
52. Ho YS, Ma HY, Chang HY, Wei BL, Lee CC, Ho SY, Guo HR, Wu TP, Chang YJ, and Wang YJ. Lipid
peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate. Food and
Chemical Toxicology. 2003. 41:621-629 （SCI：impact factor 2.186, Food Science and Technology
field：14/103; 13.6%）
53. Ching LL, Kuo CT, Wang CH, Chen TF, Ho YS, Kuo HP, and Lin CH. Involvement of nuclear
factor-kB in lipoteichoic acid-induced cyclooxygenase-2 expression in RAW 264.7 macrophages
Journal of Pharmacy and Pharmacology 2003. 55:115-123. (SCI：impact factor 1.533, Pharmacology
& Pharmacy field：123/199; 61.8%)
54. Lee YS, Lin CH, Hsu LW, Hu SY, Hsiao WT, and Ho YS. Role of ionotropic glutamate receptors in
early developing neurons derived from the p19 mouse cell line. Journal of Biomedical Science (in
press) (2003) (SCI：impact factor 1.668, Medicine, Research & Experimentalfield：43/76; 56.6%)
55. Jeng JH, Wang YJ, Chiang BL, Lee PH, Chan CP, Ho YS, Wang TM, Lee JJ, Hahn LJ, Chang MC.
(2003) Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2,
interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline.
Carcinogenesis 24(8): 1301-1315.（SCI：impact factor 5.366,Oncology field：18/127; 14.17%）
56. Chang, W. C. Jeng, J. H. Shieh, C. C. Tsai, Y. C. Ho, Y. S. Guo, H. R. Liu, H. I. Lee, C. C.Ho, S. Y.
Wang, Y. J. (2003) Skin tumor-promoting potential and systemic effects of pentachlorophenol and its
major metabolite tetrachlorohydroquinone in CD-1 Mice. Molecular Carcinogenesis 36(4):161-170
(SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
2002
57. Ying-Jan Wang, Jiiang-Huei Jeng, Rong-Jane Chen, How Tseng, Li-Ching Chen, Yu-Chih Liang,
Chien-Huang Lin, Chien-Ho Chen, Jan-Show Chu, Wei-Lu Ho,and Yuan-Soon Ho (Correspondence).
(2002) Ketoconazole potentiate the antitumor effects of nocodazole: in vivo therapy of human tumor
xenografts in nude mice. (SCI：impact factor 2.371,Biochemistry & Molecular Biology field128/261;
49% )
58. Ying-Jan Wang Chen-Fei Yu, Li-Ching Cehn, Chien-Ho Chen, Jen-Kun Lin, Yu-Chih Liang,
Chien-Huang Lin, Shyr-Yi-Lin, Chin Fa Chen, and Yuan-Soon Ho (Correspondence). (2002)
Ketoconazole potentiate terfenadine-induced apoptosis in human Hep G2 cells through inhibition of
cytochrome p450 3A4 activity. Journal of Cellular Biochemistry 87:147-159. (SCI：impact factor
3,409, Biochemistry and molecular biology field：90/262; 34.35%)
59. Chih-Hsiung Wu, Chao-Ming Huang Chien-Huang Lin, Yuan-Soon Ho, Chien-Ming Chen, and
Horng-Mo Lee. (2002) Advanced glycosylation end product induced NF-kB dependent iNOS
expression in RAW264.7 cells. Molecular and Cellular Endocrinology 194:9-17. (SCI：impact factor
2.918, Endocrinology and metabolism field：35/93; 37.6%)
60. Shyr-Yi Lin, Yu-Chih Liang, Yuan-Soon Ho, Shu-Huei Tsai, Shiann Pan, and Wen-Sen Lee. (2002)
Involvement of both extracellular signal regulated kinase and c-jun N-terminal kinase pathways in the
12-O-tetradecanoylphorbol-13-Acetate-induced upregulation of p21/Cip1 in colon cancer cells.
Molecular Carcinogenesis 35(1):21-28. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
61. Chang MC, HO YS, Lee JJ, Kok SH, Hahn LJ, Jeng JH. (2002) Prevention of the areca nut
extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol
compounds. Oral Oncology 38(3):258-265. (SCI：impact factor 2.103, Dentistry, oral surgery and
medicine field：10/49; 20.4%)
62. Yuan-Soon Ho, Hung-Bin Liou, Jen-Kun Lin, Jiiang-Huei Jeng, Min-Hsiung Pan, Yu-Ping Lin
How-Ran Guo, Sheng-Yow Ho, Ching-Chang Lee, and Ying-Jan Wang. (2002) Lipid peroxidation and
cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide. Archives
Toxicology 76(8):484-493. (SCI：impact factor 1.787, Toxicology field：42/76; 55.3%)
63. Chia-Jen Tseng, Ying-Jan Wang, Yu-Chih Liang, Jiiang-Huei Jeng, Wen-Sen Lee, Jen-Kun Lin,
Chien-Ho Chen, I-Chun Liu, and Yuan-Soon Ho （Correspondence）. (2002) Microtubule Damaging
Agents Induce Apoptosis in HL 60 Cell and G2/M Cell Cycle Arrest in HT 29 Cell Through
Independent Signaling Pathway. Toxicology 175:123-142. (SCI：impact factor 2.919, Toxicology
field：15/76; 19.74% )
64. Chih-Hsiung Wu, Jiiang-Huei Jeng, Ying-Jan Wang, Chia-Jen Tseng, Yu-Chih Liang, Chien-Ho Chen,
Horng-Mo Lee, Jen-Kun Lin, Chien-Huang Lin, Shyr-Yi Lin, Chung-Pei Li, and Yuan-Soon Ho
(Correspondence). (2002) Antitumor effects of miconazole on human colon carcinoma xenografts in
nude mice through induction of apoptosis and G0/G1 cell cycle arrest. Toxicology and Applied
Pharmacology180:22-35. （SCI：impact factor 3.846 ,Toxicology field：6/73; 5.26%）
65. Chien-Huang Lin, Chih-Hsiung Wu, Wai-yee Thum, Yuan-Soon Ho, and Horng-Mo Lee. Involvement
of p38 Mitogen-Activated Protein Kinase in PLL-AGEs-induced cyclooxygenase-2 expression in RAW
264.7 macrophages. European Journal of Pharmacology 438:143-152. (SCI：impact factor 2.522,
Pharmacology and pharmacy field：72/199; 36.2%)
66. Chen-Ho Chen, Ling-Fang Huang, Li-Ching Chen, and Yuan-Soon Ho. (2002) Ketoconazole induces
apoptosis through induction of Bax-signaling pathway in human prostate cancer cell lines. New Taipei
Journal of Medicine. 4(3):159-166.
67. Yuan-Soon Ho, Jen-Kun Lin, Ling-Fang Huang, Shyr-Yi Lin, Shann Pan, and Yu-Chih Liang. (2002)
Suppression of leukocyte adhesion molecules through inhibition of IkB kinase by tea polyphenols in
human vascular endothelial cells. New Taipei Journal of Medicine. 4(3):1-6.
68. Fat-Moon Suk, Sheng-Hsuan Chen, Yuan-Soon Ho, Shiann Pan, Horng-Yuan Lou, Chun-Chao Chang,
Ching-Ruey Hsieh, Yeong-Shan Cheng, Gi-Shih Lien. (2002) It is difficult to eradicate helicobacter
Pylori from dental plaque by triple therapy. Chinese Medical Journal 65:468-473. (SCI：impact factor
0.615, Medicine, general and internal field：73/103; 70.9%)
2001
69. Chien-Huang Lin, Yuan-Fong Lin, Meng-Chu Chang, Yuan-Soon Ho, and Horng-Mo Lee (2001)
Advanced glycosylation end products induce nitric oxide synthase expression in G6 glioma cells:
involvement of a p38 MAP kinase-dependent mechanism. Life Sciences 69:2503-2515, (2001) (SCI：
impact factor 2.389, Medicine Research & Experimental field：28/76; 36.8%)
70. Chien-Huang Lin, I-Hui Kuan, Horng-Mo Lee, Wen-Sen Lee, Joen-Rong Sheu, Yuan-Soon Ho,
Chun-Hua Wang and Han-Pin Kuo. (2001) Induction of cyclooxygenase-2 protein by lipoteichoic acid
from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear
factor-kB-dependent pathway. British Journal of Pharmacology 134:543-552, 2001 (SCI：impact
factor 3.825, Pharmacology and phamacy field：39/199; 19.6% )
71. Shyr-Yi Lin, Yu-Tza Chang, Jeng-Dean Liu ,Chung-Hsun Tu, Yuan-Soon Ho, Yi-Hsuan Lee, and
Wen-Sen Lee. (2001) Molecular mechanisms in apoptosis induced by magnolol in colon and liver.
Molecular Carcinogenesis 32:73-83 (2001). (SCI：impact factor 3.202, Oncology field： 59/165;
35.8% )
72. Chang MC, Ho YS, Lee PH, Chan CP, Lee JJ, Hahn LJ, Wang YJ and Jeng JH. (2001) Areca nut
extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial
cells：association of glutathione, reactive oxygen species and mitochondrial membrane potential.
Carcinogenesis 122(9):1527-1535, 2001（SCI：impact factor 5.366,Oncology field：18/127; 14.17%）
73. Chang MC, Ho YS, Lee JJ, Kok SH, Hahn LJ, Jeng JH. (2001) Prevention of the areca nut
extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol
compounds. Oral Oncology（accepted）(SCI：impact factor 2.103, Dentistry, oral surgery and medicine
field：10/49; 20.4%)
74. Wang Y.J.,Lee C.C., cheng W.C.,Liou H.B. and Ho Y.S.（Correspondence） (2001) Oxidative stress
and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major
metabolite tetrachlorohydroquinone. Toxicology Letters 122(2) ： 157-169. （ SCI ： impact factor
2.784,Toxicology field：13/76; 17.1%）
75. *Yuan-Soon Ho（Correspondence）Jiing-Shium Duh, Ying-Jan Wang, Yu-Chih Liang, Chien-Huang
Lin, Jiiang-Huei Jeng, Chia-Jen Tseng, Cheng-Fei Yu,Rong-Jane Chen, and Jen-Kun Lin. (2001)
Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and
G2/M cell cycle arrest in human colorectal cancer cells. International J of Cancer 91：393-401.
（SCI：impact factor 4.722, Oncology field：29/165; 17.6%）
2000
76. Ing-Kae Wang, Jen-Kun Lin, Yuan-Soon Ho, Wei-Yuan Yu, and Horng-Mo Lee. (2000) Roles of
cyclin D3 expression in PMA-induced human leukemia cells (HL 60) apoptosis. Journal of Genetics
and Molecular Biology 11(1), 1-11. （SCI：impact factor 2.73,Toxicology field：5/77）
77. Rong-Jane Chen, Wen-Sen Lee, Yu-Chih Liang, Jen-Kun Lin, Ying-Jan Wang, Chien-Huang Lin,
Jui-Ying Hsieh, Chiu-Chin Chaing, and Yuan-Soon Ho （Correspondence）(2000) Ketoconazole
Induces G0/G1 Arrest in Human Colorectal and Hepatocellular Carcinoma Cell Lines. Toxicology and
Applied Pharmacology 169: 132-141. （SCI：impact factor 3.846 ,Toxicology field：6/73; 5.26%）
78. Wang YJ, Ho YS, Jeng JH, Su HC, Lee CC. (2000) Different cell death mechanisms and gene
expression in human cells induced by pentachlorophenol and its major metabolite,
tetrachlorohydroquinone. Chemico-Biological Interactions 128:173-188. （ SCI ： impact factor
1.8,Toxicology field：40/76; 52.6%）
79. Jeng JH, Ho YS, Chan CP, Wang YJ, Hahn LJ, Lei D, Hsu CC, Chang MC. (2000) Areca Nut
ExtractUp-Regulates Prostaglandin Production, Cyclooxygenase-2 mRNA and Protein Expression of
Human Oral Keratinocytes. Carcinogenesis 21(7):1365-1370. （SCI：impact factor 5.366,Oncology
field：18/127; 14.17%）
80. Chien-Huang Lin, Sheng-Yuan Sheu, Horng-Mo Lee, Yuan-Soon Ho, Wen-Sen Lee, Wun-Chang Ko
and Joen-Rong Sheu. (2000) Involvement of protein kinase C- in IL-1 -induced cyclo-oxygenase-2
expression in human pulmonary epithelial cells. Molecular Pharmacology 57:36-43. (SCI：impact
factor 4.469,
Pharmacology and pharmacy field：26/199; 13.1% )
1999
81. Yuan-Soon Ho, Hsu-Ling Liu, Jiing-Shium Duh, Rong-Jane Chen, Wei-Lu Ho, Jiiang-Huei Jeng,
Ying-Jan Wang, and Jen-Kun Lin. (1999) Induction of Apoptosis by S-nitrosoglutathione and Cu2+ or
Ni2+ ion through modulating Bax, Bad and Bcl-2 proteins in Human Colon Adenocarcinoma Cells.
Molecular Carcinogenesis 26:201-211. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
82. Jeng Jiiang-Huei, Chan Chiu-Po, Ho Yuan-Soon, Lin Chun-Pin, Hsieh Chi-Chuan, and Chang
Mei-Chi. (1999) Effects of butyrate and propionate on the adhesion, growth, cell cycle kinetics and
protein synthesis of cultured human gingival fibroblasts. J of Periodontology 70(12):1435-1442.
（SCI：impact factor 1.703,Dentistry,Oral surgery and medicine field：16/49; 32.7%）
83. Ho YS, Lee HM, Chang CR, and Lin JK. (1999) Induction of bax protein and degradation of lamin A
during the p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines.
Biochemical Pharmacology, 57:143-154. （SCI：impact factor 4.06,Pharmacology and pharmacy
field：45/199; 15.6%）
1998
84. Wang YJ, Ho YS, Pan MH, and Lin JK. (1998) Mechanisms of cell death induced by nitric oxide and
peroxynitrite in Calu-1 cells. Environmental Toxicology and Pharmacology Vol. 6:35-44. （SCI：
impact factor 1.119,Enviromental sciences field：73/144; 50.7%）
85. Ho YS, Tsai PW, Yu CF, Liu HL, Chen RJ, and Lin JK. (1998) Ketoconazole-induced apoptosis
through p53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines.
Toxicology and Applied Pharmacology Vol. 153(1):39-47. （SCI：impact factor 3.846 ,Toxicology
field：6/73; 5.26%）
1997
86. Ho YS, Lee HM, Mou TC, Wang YJ, and Lin JK. (1997) Suppression of nitric oxide induced apoptosis
by L-N-acetyl-cysteine through modulation levels of glutathione, Bcl-2 and Bax proteins. Molecular
Carcinogenesis Vol. 19:101-113. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
87. Wang YJ, Ho YS, Chu SW, Lien HJ, Liu TH, and Lin JK. (1997) Induction of glutathione depletion,
p53 protein accumulation and tumor promotion by tetrachloro-hydroquinone, a toxic metabolite of
pentachlorophenol. Chemico-Biological Interactions. Vol.105:1-16. （ SCI ： impact factor
1.8,Toxicology field：40/76; 52.6%）
88. Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY. and Lin JK. (1997) Stability of curcumin in
buffer solutions and characterization of its degradation products. Journal of Pharmaceutical and
Biomedical Analysis Vol.15:1867-1876. （SCI：impact factor 2.032,Chemistry, analytical field：24/68;
35.3%）
1996
89. Ho YS, Wang YJ, and Lin JK. (1996) Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide
and their association with apoptosis in human cancer cells. Molecular Carcinogenesis Vol. 16:20-31.
(SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
1992~1995
90. Ho YS, and Lin JK. (1995) Preferential promutagenic lesions at exons 7-8 of human p53 genomic
DNA induced by the direct-acting hepatocarcinogens N-nitroso-2-acetylaminofluorene and
N-acetoxy-2-acetylaminofluorene. Cancer Letters Vol. 95:39-47. （SCI：impact factor 3.277, Oncology
field：48/127;37.8%）
91. Ho YS, Cheng HT, Wang YJ, and Lin JK. (1995) P53 gene mutational spectra in hepatocellular
carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats. Molecular
Carcinogenesis. Vol. 13:182-190. (SCI：impact factor 3.202, Oncology field： 59/165; 35.8% )
92. Ho YS, and Lin JK. (1994) N-nitroso-2-acetylaminofluorene: A direct-acting carcinogen inducing
hepatocellular carcinoma in Sprague-Dawley rats. Japanese Journal of Cancer Research. Vol. 85, pp.
794-800. （SCI：impact factor 2.177, Oncology field：38/105）
93. Wang YJ, Ho YS, Lo MJ, and Lin JK. (1994) Oxidative modification of DNA bases in rat liver and
lung during chemical carcinogenesis and aging. Chemico-Biological Interactions. Vol. 94, pp. 135-145.
（SCI：impact factor 1.8,Toxicology field：40/76; 52.6%）
94. Lin JK, and Ho YS. (1994) Hepatotoxic actions of dietary amines. Toxicology & Ecotoxicology News
Vol. 1 No., pp. 82-87.(Review article)
95. Lin JK, and Ho YS. (1992) Hepatotoxicity and hepatocarcinogenicity in rats fed squid with or without
exogenous nitrite. Food Chemical Toxicology Vol. 30(8), 695-702, 1992. （SCI：impact factor 2.186,
Food Science and Technology field：14/103; 13.6%）
二、研討會論文 (Conference paper)
1. Wang YJ, Ho YS, Lo MJ, and Lin JK. (1994)Oxidative modification of DNA bases in rat liver
and lung during chemical carcinogenesis and aging. Proceeding of the 9th Joint annual
Conferences of Biomedical Science, March 26-27, 1994. NTU, Taipei, p41, Article No. 94.
2. Ho YS, and Lin JK. Preferencial promutagenic lesions at exons 6-8 of human p53 genomic
DNA induced by the hepatocarcinogen N-Nitroso-2-acetylaminofluorene. Proceeding of the 9th
Joint Annual Conferences of Biomedical Science. March 26-27, 1994. NTU, Taipei, p116,
Article No. 393.
3. Lin JK, Ho YS, Cgeng HT, Wang YJ, and Lin-Shiau SY. Mutational spectraof p53 gene in
hepatocellular
carcinomas
induced
by
2-acetylaminofluorene
and
N-nitroso-2-acetylaminofluorenein rats. Proceedings of the VII International Congress of
Toxicology. 7(1):92-PD-8, 1995.
4. Mou TC, Su SJ, Ho YS, Lin YH and Lee HM. Relationship between infection of Helicobacter
Pylori possessing cag A gene and chronic gastiric inflammation. Proceeding of the 11th Joint
Annual Conference of Biomedical Science, Apr 13-14, 1996, NTU. Taipei, p184, Article No.
p166.
5. HO YS, Wang YJ, and Lin JK. Induction of p53 and p21/WAF1/CIP1 expression b y nitric oxide
and their association with apoptosis in human cancer cells. Proceeding of the 11th Joint Annula
Conference of Biomedical Sciences, Apr 13-14, 1996. NTU, Taipei, p108, article No. 109.
6. Ho YS, Cheng HT, Wang YJ, and Lin JK. P53 gene mutational spectra in hepatocellular
carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
Proceeding of the 11th Joint Annual Conference of Biomedical Science, March 25-26, 1995,
NTU. Taipei, p129, Article No. p218.
7. Ho YS and Lin J.K. Minimal deviation hepatocellular carcinoma induced by
N-nitroso-2-acetylaminofluorene. Proceedings of the 8th Joint Annual
Conference of
Biomedical Sciences March 20-21, 1993. National Taiwan University , Taipei, p59, Article 195
8. Ho YS and Lin J.K. Suppression of nitric oxide induced apoptosis by-L-N-acetyl-cysteine
through modulation levels of glutathione, bcl-2 and bax proteins Proceedings of the 12th Joint
Annual Conference of Biomedical Sciences April 19-20, 1997. National Taiwan University ,
Taipei, p59, Article No p37
9. Liu H.L. and Ho YS Inhibition of p27, PKA and PKC expression by GSNO in HT 29 cells.
Proceedings of the 13th Joint Annual Conference of Biomedical Sciences April 18-19, 1998.
National Taiwan University , Taipei, p70, Article No p122.
10. Wang I.K., Lin J.K., Ho YS, Yu W.Y., and Lee H.M.. Roles of cyclin D3 expression in
PMA-induced human leukemia (HL-60) cell apoptosis. Proceedings of the 13th Joint Annual
Conference of Biomedical Sciences April 18-19, 1998. National Taiwan University , Taipei,
p147, Article No 75.
三、出席國際會議研討會論文:
2002
會議名稱: 第九屆世界自由基生物醫學年會
會議地點: 美國德州聖安東尼奧市
發表論文: 1.Yuan-Soon Ho and Ying-Jan Wang. Lipid Peroxidation and Cell Death Mechanisms in
Rats and Human Cells Induced by Chloral Hydrate. 9th Annual Meeting of the Oxygen Society.
November 20-24, 2002, San Antonio, TX, USA. 2. Ying-Jan Wang and Yuan-Soon Ho. Skin
tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite
tetrachlorohydroquinone in CD-1 mice. 9th Annual Meeting of the Oxygen Society. November
20-24, 2002, San Antonio, TX, USA.
2003
會議名稱: 第十屆世界自由基生物醫學年會
會議地點: 美國美國西雅圖市
發 表 論 文 : 3.Y-S Ho, C-H Wu, W-L Ho, H-L Chen and Y-J Wang. Topical application of
2,3,7,8-tetrachlorodibenzo-p-dioxin lack of skin tumor-promoting potency but induce hepatic injury
and tumor necrosis factor-a expression in ICR male mice. 10th Annual Meeting of the Oxygen
Society. November 12-16, 2003, Seatle, USA.
2004
會議名稱: 第十一屆世界自由基生物醫學年會
會議地點: 美屬威京群島
發表論文: Yuan-Soon Ho1, and Wei-Ling Tso. Studies of the antitumor effects of loratadine on
human colon cancer cells. 11th Annual Meeting of the Oxygen Society. November 17-20, 2003,
Virgin Islands, USA.
2005
會議名稱: 2005 年太平洋化學會年會
會議地點: 夏威夷群島
發表論文: Wu, Chih Hsiung1; Wang, Ying-Jan ; Ho, Yuan-Soon. Involvement of proapoptotic Bcl-2
family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells
International Chemical Congress of Pacific Basin Societies (2005) November 15-20, 2005, Hawaii
USA.
2006
會議名稱: 國際環境與流行病學暴露年會
會議地點: 法國 巴黎
發 表 論 文 : PP LIN1, LW CHANG2, YJ WANG3, YS HO4 The possible mechanism of
TCDD-mediated tumor promotion in NNK-initiated lung tumorigenesis in female A/J mice.
International conference on environmental epidemiology & exposure November 2-6, Paris France.
會議名稱: 第 13 屆世界自由基與生物醫學年會
會議地點: 美國 丹佛
發表論文: Chih-Hsiung Wu, and
Yuan-Soon Ho Studies on the molecular mechanisms of nicotinic
receptors-mediated carcinogenic effects on human breast cancer cells, SFRBM 2006 - 13th Annual
Meeting of the Society for Free Radical Biology and Medicine . November 15-19, 2007, Denver, CO
2007
會議名稱: 2007 年第 234 屆美國化學會年會
會議地點: 美國 波士頓 (應邀演講)
發表論文:Chih-Hsiung Wu, and Yuan-Soon Ho , Studies on the molecular mechanisms of
Phloretin-induced apoptosis in human hepatocellular carcinoma (HepG2) cell International
Chemical Congress of Pacific Basin Societies (2007) October 16-20, 2007, Boston USA.
2008
會議名稱: 2008 年第 2 屆第 2 屆亞洲環境化學會年會
會議地點: 韓國 濟州島
發表論文:Chih-Hsiung Wu, Ying-Jan Wang and Yuan-Soon Ho , In vitro and in vivo studies on the
smoking-induced carcinogenic effects of breast cancer patients in Taiwan (2008) April 16-19, 2008,
JeJu Korea.
會議名稱: 2008 年第 1 屆世界癌症大會
會議地點: 中國 上海
發表論文: Chih-Hsiung Wu,* and Yuan-Soon Ho. Studies on the potential molecular mechanisms of
nicotinic receptors-mediated carcinogenic effects in human breast cancer cells (2008) Jun 12-15,
2008. Shanghai, China. (Invited speaker)
發表論文: Yuan-Soon Ho*, and Chih-Hsiung Wu. Involvement of proapoptotic Bcl-2 family proteins
in antifungal agent terbinafine-induced mitochondrial dysfunction and apoptosis in human leukemia
cells (2008) Jun 12-15, 2008. Shanghai, China.
2009
會議名稱: 第 2 屆世界癌症大會
會議地點: 中國 北京
發表論文: In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells
through inhibition of type II glucose transporter
會議名稱: 第 12 屆國際芳香族化學年會
會議地點: 希臘
發表論文: Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through
induction of apoptosis in human Hep G2 cells
會議名稱: 2009 年國際營養學與功能性食品大會年會
會議地點: 舊金山
發表論文: Studies on the Anti-Tumor Mechanisms of Garcinol-Induced Cyclin D3 Expression in
Human Breast Cancer Cells
會議名稱: 第 3 屆世界癌症大會
會議地點: 新加坡
發 表 論 文 : Estrogen receptor activation confer nicotine and estrogen-induced
expression in human breast cancer cells
9-nAChR
三、專書
1. 生化與生物技術辭彙 Lin’s Biochemical and Biotechnological Lexicon/何元順等編著; 林仁混主
編. 第一版. 臺北市: 藝軒, 民國 86 年.
2. Recent Advances in Food and Flavor Chemistry , Edited by C-T Ho et al. page 400-410, 2010.
(ISBN 978-1-84755-201-3)
3.
表 C302
共
頁
第
頁
六、研發成果智慧財產權及其應用績效：
（一）請將個人研發成果所產生之智慧財產權及其應用績效分為 1.專利 2.技術移轉 3.著作授權
4.其他等類別，分別填入下列表中。如欄位不足，請自行加印填寫。
（二）填寫順序請依專利期間起始日排列，或技術移轉及著作授權之簽約日期排列。
1.專利：
請填入目前仍有效之專利。
「類別」請填入代碼：(A)發明專利(B)新型專利(C)新式樣專利。
類別
專利名稱
國別
專利號碼
發明人
專利權人 專利核准
日
期 國科會計畫編號
2.技術移轉：
技術名稱
專利名稱
授權單位
被授權單位
簽約日期
國科會計畫編號
產生績效：(可另紙繕寫)
3.著作授權「類別」分(1)語文著作(2)電腦程式著作(3)視聽著作(4)錄音著作(5)其他，請擇一代碼填入。
著作名稱
類別
著作人
著作財產權人 被授權人 國科會計畫編號
產生績效：(可另紙繕寫)
4.其他協助產業技術發展之具體績效
表 C303
共
頁
第
頁
七、近三年內執行及申請中之研究計畫：
類神經細胞在三維纖維狀
基質上的細胞行為及其基
因分析
乳癌細胞中
a9-尼古丁乙醯
(99-2221-E-038-002-)
膽鹼受體參與荷爾蒙拮抗
劑(tamoxifen)治療所產生
以電氣紡絲製備片狀細胞
抗藥性之分子機轉探討
工學用基質
(98-2320-B-038-006-MY3)
(I)(97-2221-E-038-011-)
蘋果多酚成份 phloretin 誘
發乳癌細胞凋亡之分子機
制探討
葡萄糖傳遞受體抑制劑應
(97-2314-B-038-034-MY3)
用於肝癌治療之分子機制
探討
五氯酚促進戴奧辛誘發肝
(96-2628-B-038-003-MY3)
毒性及肝癌的機轉探討
(95-2314-B-006-095-MY3)
以奈米級纖維狀薄膜仿波
曼氏膜進行角膜上皮再生
之細胞工學(重點研究計
尼古丁與性荷爾蒙誘發乳
畫)(95-2221-E-038-004-)
癌細胞 a9-尼古丁乙醯膽鹼
受體轉錄表現之調控機轉
療黴舒(Terbinafine)抑癌作
(95-2320-B-038-016-MY3)
用之分子機制探討
(3/3)(95-2320-B-038-011-)
Terbinafine 的抗血管增生
與抗癌作用之研究
(2/2)(94-2320-B-038-005-)
以電氣紡絲進行生物降解
性纖維多向配向薄膜的製
備及對細胞行為之影響
酒精誘發肝纖維化機制探
(94-2213-E-038-007-)
討及類黃酮之抑制角色
(94-2314-B-038-060-)
療黴舒(Terbinafine)抑癌作
用之分子機制探討
(2/3)(94-2320-B-038-032-)
表 C304
728,000
行政院國家
科學委員會
2010/08/01 ~
2011/07/31
執行中
共同主持
人
行政院國家
科學委員會
2009/08/01 ~
2012/07/31
執行中
主持人
行政院國家
科學委員會
2008/08/01 ~
2009/07/31
已結案
共同主持 1,146,000
人
行政院國家
科學委員會
2008/08/01 ~
2011/07/31
執行中
共同主持 3,660,000
人
行政院國家
科學委員會
2007/08/01 ~
2010/07/31
執行中
行政院國家
科學委員會
2006/08/01 ~
2009/07/31
已結案
共同主持 3,063,000
人
行政院國家
科學委員會
2006/08/01 ~
2007/07/31
已結案
共同主持
人
行政院國家
科學委員會
2006/08/01 ~
2009/07/31
已結案
主持人
行政院國家
科學委員會
2006/08/01 ~
2007/07/31
已結案
主持人
行政院國家
科學委員會
2005/08/01 ~
2006/07/31
共同主持
人
891,000
已結案
行政院國家
科學委員會
2005/08/01 ~
2006/07/31
共同主持
人
820,000
已結案
行政院國家
科學委員會
2005/08/01 ~
2006/07/31
共同主持
人
715,000
已結案
行政院國家
科學委員會
2005/08/01 ~
2006/07/31
已結案
主持人
3,960,000
4,308,000
主持人
861,000
4,183,000
1,095,000
1,090,000
共
頁
第
頁
研究人員近五年內研究成果統計及獲獎勵情形（表 A）
1. 五年內曾懷孕生產或請育嬰假者，得填寫近七年內研究成果統計及獲獎情形，但須附證明文件。
2. 五年內曾服國民義務役者，得加上實際服役時間延長選填研究成果及獲獎情形，但須附證明文件。
(修正：2009/11/10)
研究人員姓名
何元順 教授
任職機關系所
台北醫學大學 醫學檢驗暨生物技術學系
※本表所填寫下列各項數量資料均應以研究人員個人資料表所填列之資料為依據。
(一)請填寫五年內(2005.1.1 迄今)已發表或已被接受發表之研究論文數量
SCI、SSCI、EI 期刊論文
研究成果
(包括填表說明六(一)之 1.所列四類論文：正式論文、簡報型論文、
病例報告、綜合評論)
SCI 論文
作者序
SSCI 論文
EI 論文
其他學術期刊論文
(左列 3 類以外之期
刊論文)
第一作者
論文篇數
6
非第一作者之通訊作者
論文篇數
18
非第一或通訊作者
之其他序位作者
論文篇數
16
2
40
2
總篇(件)數
(以上三項總和)
SCI 、SSCI、EI 之期刊論文資料，可就近至各大學圖書館、國科會科技政策研究與資訊中心等查閱
或上網檢索。上述 SCI、SSCI 及 EI 期刊資料以 2008 年版本為準。
(二)請填寫五年內(2005.1.1 迄今)已獲得或已刊登之下列研究成果數量
成果名稱
專利
技轉
研討會論文摘要 專書或專書章節
其他
（件、冊、章、篇）數
(三)請填寫五年內(2005.1.1 迄今)獲得獎勵情形
年
度
請選填下列獎項名稱：
傑出獎、吳大猷獎、其他獎(請填其他獎之名稱)
1. 93 年(93.1.1~93.12.31)
國科會甲種研究獎
2. 94 年(94.1.1~94.12.31)
國科會甲種研究獎
3. 95 年(94.1.1~95.12.31)
國科會甲種研究獎
4. 96 年(95.1.1~96.12.31)
國科會甲種研究獎
5. 97 年(97.1.1~迄今)
國科會甲種研究獎
研究人員近五年內研究表現指數（RPI）統計（表 B）
(修正：2009/11/10)
姓
名： 何元順 教授
機關系所： 台北醫學大學 醫學檢驗暨生物技術學系
■滿5 年以上(選最佳10 篇)； □滿4 年(選最佳7 篇)； □滿3 年(選最佳5 篇)； □未滿3 年(選最佳3 篇)
研究年資： 1.五年內曾生產或請育嬰假者，得於七年內選擇上列所須論文篇數，研究年資則扣除 2 年後，於上列四
(請打)
序
號
成果
類別
代碼
項年資中勾選年資，並請附上生產或請育嬰假證明文件。
2.五年內曾服國民義務役者，得加上實際服役時間延長選擇上列所須論文篇數，研究年資則為扣除實際
服役時間，於上列四項年資中勾選您的年資，並請附上服國民義務役證明文件。
五年內(2005.1.1 迄今)代表性研究成果名稱
論文
刊登
雜誌
分類
分數
(J)
★1.學術論文必須填寫所有作者(按期刊所刊登之原排序)、著作名 性質
稱、期刊名稱、年份、卷期、起迄頁數。
分數
★2.專利必須填寫專利名稱、發明人、證書號碼、國別、專利期限。
★3.技術移轉必須填寫技術名稱、技轉金額及對象、年份。
(參看填表
(C)
說明之三) ★4.刊登雜誌分類排名以 2008 年版本之 SCI 及 SSCI 資料為準。
1
01
2
01
3
01
4
01
5
01
Chia-Hwa Lee, Ching-Shui Huang, Ching-Shyang Chen,
Shih-Hsin Tu, Ying-Jan Wang, Yu-Jia, Chang, Ka-Wai Tam,
Po-Li Wei, Tzu-Chun Cheng, Jan-Show Chu, Li-Ching Chen,
Chih-Hsiung Wu and Yuan-Soon Ho
(corresponder)
(2010) Overexpression and Activation of the 9-Nicotinic 3
Receptor during Tumorigenesis in Human Breast Epithelial
Cells. The Journal of National Cancer Institute (acepted)
（SCI：impact factor 14.069, Oncology field：6/165; 3.6%）.
Shih-Hsin Tu, Chih-Chiang Chang, Ching-Shyang Chen,
Ka-Wai Tam, Ying-Jan Wang, Chia-Hwa Lee, Hsiao-Wei Lin,
Tzu-Chun Cheng, Ching-Shui Huang, Jan-Show Chu,
Neng-Yao Shih, Li-Ching Chen, Sy-Jye Leu, Yuan-Soon Ho
(corresponder)* and Chih-Hsiung Wu* (2009) Increased 3
expression of enolase  in human breast cancer confers
tamoxifen resistance in human breast cancer cells Breast
Cancer Research and Treatment (in press): （SCI：impact
factor 4.696, Oncology field：30/165; 18.2%）
Yung-Leun Shih, Hui-Ching Liu, Ching-Shyang Chen,
Chung-Huei Hsu, Min-Hsiung Pan, Hui-Wen Chang,
Chien-Hsi Chang, Feng-Chia Chen, Chi-Tang Ho, Yi-Yuan
Yang, and Yuan-Soon Ho (corresponder)
(2009)
Combination treatment with luteolin and quercetin enhances
anti-proliferative effects in nicotine-treated MDA-MB-231 3
cells by downregulating nicotinic acetylcholine receptors.
Journal of Agriculture and Food Chemistry (58):235-241:
（SCI：impact factor 2.469, Agriculture, Multidisciplinary
field：2/44; 4.5%）
Ching-Shyang Chen, Chang-Da Hsieh, Chia-Hwa Lee,
Chi-Tang Ho, Min-Hsiung Pan, Ching-Shui Huang,
Shih-Hsin Tu, Ying-Jan Wang, Chih-Hsiung, Wu, and
Yuan-Soon Ho (corresponder)(2010). Nicotine-induced
human breast cancer cell proliferation is attenuated by 3
garcinol through down-regulation of nicotinic receptor and
cyclin D3 proteins. Breast Cancer Research and
Treatment.(in press):-. （SCI：impact factor 4.696, Oncology
field：30/165; 18.2%）
Ching-Shui Huang, Wei-Lu Ho, Wen-Sen Lee, Ming-Thau
Sheu, Ying-Jan Wang, Shih-Hsin Tu, Rong-Jane Chen,
Jan-Show Chu, Li-Ching Chen, Chia-Hwa Lee, How Tseng,
Yuan-Soon Ho (corresponder) and Chih-Hsiung Wu
SP1-regulated p27/Kip1 gene expression is involved in 3
terbinafine-induced human A431 cancer cell differentiation:
an in vitro and in vivo study Biochemical Pharmacology
75:1783-1796, 2008.（SCI：impact factor 4.06,Pharmacology
and pharmacy field：45/199; 15.6%）
作者
排名
分數
分數
(CxJxA)
(A)
5
14.06
211.035
9
5
5
75
5
5
75
5
5
75
5
5
75
6
01
7
01
8
01
9
01
10
Tain-Junn Cheng, Ying-Jan Wang, Wei-Wan Kao, Rong-Jane
Chen, Yuan-Soon Ho (corresponder) Protection against
arsenic trioxide-induced autophagic cell death in U118 human
glioma cells by use of lipoic acid. Food and Chemical 3
Toxicology 45:1027-1038, 2008 （SCI：impact factor 2.186,
Food Science and Technology field：14/103; 13.6%）
Yean-Hwei Chou, Yuan-Soon Ho (corresponder), Chi-Chen
Wu, Chiah-Yang Chai, Soul-Chin Chen, Chia-Hwa Lee,
Pei-Shan Tsai, and Chih-Hsiung Wu. Tubulozole-induced
G2/M cell cycle arrest in human colon cancer cells through
formation of microtubule polymerization mediated by 3
ERK1/2 and Chk1 kinase activation. Food and Chemical
Toxicology 45:1356-1367 （SCI：impact factor 2.186, Food
Science and Technology field：14/103; 13.6%）
Yuan-Soon Ho, Ching-Shu Lai, Hsin-I Liu, Sheng-Yow Ho,
Chein Tai, Min-Hsiung Pan and Ying-Jan Wang (2006)
Dihydrolipoic acid inhibits skin tumor promotion through
anti-inflammation
and
anti-oxidation.
Biochemical 3
Pharmacology 73(11):1786-1795. (SCI ： impact factor
4.06,Pharmacology and pharmacy field：45/199; 15.6%)
37. Yang Kuo-Ching, Chi-Chen Wu, Chih-Hsiung Wu,
Chen Jur-Hao, Chien-Hwa Chu, Chien-Ho Chen, Chou
Yean-Hwei, Ying-Jan Wang, Wen-Sen Lee, How Tseng,
Shyr-Yi Lin, Chia-Hwa Lee, and Yuan-Soon Ho
(corresponder) (2006) Involvement of proapoptotic Bcl-2 3
family members in terbinafine-induced mitochondrial
dysfunction and apoptosis in HL60 cells Food and Chemical
Toxicology. 44:214-226 （SCI：impact factor 2.186, Food
Science and Technology field：14/103; 13.6%）
Yuan-Soon Ho, Chien-Ho Chen, Ying-Jan Wang, Richard G.
Pestell , Chris Albanese, Rong-Jane Chen, Mei-Chi Chang,
Jiiang-Huei Jeng, Shyr-Yi Lin, Yu-Chih Liang, How Tseng,
Wen-Sen Lee, Jen-Kun Lin, Jan-Show Chu, Li-Ching Chen,
Chia-Hwa Lee, Wei-Ling Tso, Yann-Chwen Lai, and
Chih-Hsiung Wu (2005) Tobacco specific carcinogen
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) 3
induces cell proliferation in normal human bronchial
epithelial cells through NF
B activation and cyclin D1
upregulation. Toxicology and Applied
Pharmacology
180:22-35. （SCI：impact factor 3.846 ,Toxicology field：
6/73; 5.26%
5
5
75
5
5
75
5
5
75
5
5
75
5
5
75
積分（以上各項研究成果分數之總和）
研究表現指數(RPI)【(積分 x100)/
886.035
指標上限滿分】
118.14
★註 1.已被接受但未出刊之論文須附接受函或相關證明文件，技術移轉須附上合約書，專利須附上專利證書，採相同
貢獻作者計分者須附該論文註明「相同貢獻作者」部份之電子檔，五年內曾生產或請育嬰假或曾服國民義務役
而延長選取研究成果著作期限者請附證明文件，前述文件請掃描附於本表之後一併上傳，未附者將不採計。
★註 2.申請人填寫本表之資料經核對結果，若填寫不實將予更正，無法辨識者將取消計分；蓄意造假者，其申請案不
予通過外，並送本會學術倫理審議委員會按情節輕重程度議處。