Advanced Research Program B 1999 Advanced Technology Program B 1999 Report of Awards May 2000 Texas Higher Education Coordinating Board Division of Finance, Campus Planning and Research P.O. Box 12788 Austin, Texas 78711 Texas Higher Education Coordinating Board Pamela P. Willeford (Chairman) Martin Basaldúa, M.D. (Vice Chair) Jodie L. Jiles (Secretary) William C. Atkinson Dolores Hutto Carruth, M.D. Ricardo G. Cigarroa Jr., M.D. Kevin P. Eltife Raul B. Fernandez Robert I. Fernandez Cathy Obriotti Green Gerry Griffin Carey Hobbs Steve Late Adair Margo Leonard Rauch Hector de J. Ruiz Robert W. Shepard Terderma L. Ussery, II Austin Houston Houston Bryan Irving Laredo Tyler San Antonio Fort Worth San Antonio Hunt Waco Odessa El Paso Houston Austin Harlingen Dallas COORDINATING BOARD MISSION The mission of the Texas Higher Education Coordinating Board is to provide the Legislature advice and comprehensive planning capability for higher education, to coordinate the effective delivery of higher education, to administer programs efficiently and to improve higher education for the people of Texas. COORDINATING BOARD PHILOSOPHY The Texas Higher Education Coordinating Board will promote access to quality higher education across the state with the conviction that access without quality is mediocrity and that quality without access is unacceptable. The Board will be open, ethical, responsive, and committed to public service. The Board will approach its work with a sense of purpose and responsibility to the people of Texas and is committed to the best use of public monies. Created by the Texas Legislature in 1965, the Texas Higher Education Coordinating Board works with institutions of higher education, other state agencies, the Legislature and the Governor to ensure that Texans seeking higher education have access to high quality programs. The Board's overall responsibilities include assessing the state of higher education in Texas, making recommendations to the Governor, Legislature and institutions for its enhancement, and establishing policies for the efficient and effective use of the state's higher education resources. Table of Contents Introduction .................................................................................................................................... 1 Role of the Advisory Committee on Research Programs .............................................................. 2 Solicitation of Research Proposals ................................................................................................ 3 The Peer Review Process ............................................................................................................. 4 Outcomes of the 1999 Advanced Research and Advanced Technology Program Reviews ....... 5 Biennial Evaluations of the Advanced Research and Advanced Technology Programs .............................................................................................................. 6 Acknowledgments .......................................................................................................................... 6 Appendices Appendix A: Affiliations of Review Panelists ................................................................ A-1 Appendix B: Appendix C: Appendix D: Appendix E: Appendix F: Proposals Submitted by Research Area ....................................................... List of Funded Proposals ................................................................................ Funding by Institution ...................................................................................... Comparison of Awards in 1995, 1997 and 1999 ............................................ Proposal Evaluation Forms ............................................................................. B-1 C-1 D-1 E-1 F-1 List of Tables Table 1: Advisory Committee on Research Programs, 1999 ................................................. 2 Table 2: Preliminary Allocations .............................................................................................. 3 Table 3: 1999 Review Panel Chairs ........................................................................................ 5 i Advanced Research Program/Advanced Technology Program Report of Awards Introduction In 1987, the 70th Texas Legislature created the Advanced Research Program (ARP) and the Advanced Technology Program (ATP) as complementary, statewide research programs providing peerreviewed, competitive grants to Texas college and university researchers. For the 1987-1988 biennium $60 million was appropriated. Since then, approximately the same amount has been appropriated for the programs for each of the six subsequent biennia. The Advanced Research Program is devoted to basic research designed to attract and retain the best students and researchers and help provide the knowledge base needed for innovation. Researchers at all public institutions of higher education are eligible to compete. The Advanced Technology Program is devoted to research with a technological objective and a long-term economic goal, but retains a strong educational component. It is designed to promote the state's economic growth and diversification by increasing the number and quality of scientists and engineers in Texas, enlarging the technology base available to business and industry, creating new products and services, and attracting new industries to Texas. Researchers at all public and independent institutions of higher education are eligible to compete. In 1999, three types of proposals were considered: Advanced Research Program proposals to support basic research in nine areas specified in statute. Proposals to the biological sciences research area were invited based on peer review of shorter pre-proposals. Advanced Technology Program proposals to support applied research in 11 areas specified in statute, and a newly created transportation research area. Proposals to the biomedicine and medical biotechnology research areas were invited based on peer review of shorter preproposals. ATP Technology Development and Transfer proposals to continue the development and transfer to the private sector of technology created under previous Advanced Research Program or Advanced Technology Program grants. A separate competition was held for each type of award. The implementation strategy for the ARP/ATP features three key elements: Policy guidelines and oversight are provided by the distinguished Texas scientists and engineers who are members of the Coordinating Board's Advisory Committee on Research Programs (ACORP); Proposals are solicited in 21 different research areas from faculty members at institutions of higher education in the state; and Proposals are peer reviewed by nationally prominent scientific and technological professionals, including industry representatives from Texas and throughout the nation. 1 This report outlines the procedures followed during the 1999 ARP/ATP proposal solicitation and review process and describes the outcomes of the competitions. Role of the Advisory Committee on Research Programs The Coordinating Board's Advisory Committee on Research Programs (ACORP) provides direction and guidance to the programs and ensures their quality. Chaired by Dr. Norman Hackerman, it is composed of 12 eminent Texas scientists and engineers from academe and industry representing a wide range of disciplines (see Table 1). Currently, four members of the National Academy of Science or the National Academy of Engineering serve on the Committee. The Committee consistently recommends that the Coordinating Board seek proposals from all possible sources within the Texas higher education system and select the very best of these through a fair and open process. ACORP reviews the program announcement, makes a preliminary allocation of funds among disciplines, and reviews the recommendations of the review panels. Table 1 Advisory Committee on Research Programs, 1999 (Membership list through December 31, 1999) Norman Hackerman (Chair) ...................................................................... President Emeritus, Rice University Keith W. Brown .................................................................................... President and CEO, GeneScreen, Inc. Paul C.W. Chu .....................................T.L.L. Temple Chair and Director, Texas Center for Superconductivity, University of Houston Rinn Cleavelin ......................................................................................... Chief Operating Officer, SEMATECH Aaron Cohen ................. H.B. Zachry Professor, Mechanical Engineering Department, Texas A&M University R. Gary Daniels ............................................. Senior Vice President and General Manager (retired), Motorola Karin Loftin ........................................................................... Senior Scientist, Wyle Laboratories/Life Sciences John McKetta ......................................................... Professor Emeritus and Joe C. Walter, Jr. Chair Emeritus, Department of Chemical Engineering, The University of Texas at Austin Max Navarro ..........................................................President and CEO, Operational Technologies Corporation William B. Neaves .................................................................... Executive Vice President for Academic Affairs, The University of Texas Southwestern Medical Center at Dallas Billy E. Welch ................................................................. Director (retired), Armstrong Laboratory, San Antonio Jane L. Winer........................................................ Dean, College of Arts and Sciences, Texas Tech University Jane L. Winer ....................................................... Dean, College of Arts and Sciences, Texas Tech University In 1999, ACORP recommended incorporating research areas that received few submissions in previous competitions into other research areas. As a result, astronomy, atmospheric sciences, and marine sciences in the Advanced Research Program and marine technology in the Advanced Technology Program are no longer listed as separate areas. In the Advanced Technology Program, agricultural biotechnology was incorporated into the agriculture research area and the biotechnology research area was renamed medical biotechnology to facilitate review panel focus. To emphasize the state=s increasing interest in transportation issues, ACORP created a transportation research area in 2 the Advanced Technology Program. ACORP recommended that reviewers place special emphasis on research projects that address environmental and water resource issues of the Texas-Mexico border region, reflecting similar legislative interest in this area. Solicitation of Research Proposals ACORP recommended the announcement of proposal solicitation and evaluation in March 1999. The committee reviewed the proposal submission process, recruitment of reviewers, and the peer review process. ACORP approximated budget allocations for the targeted research areas (see Table 2). Exact allocations were to be based upon the quality of proposals within each area. In March 1999, the Coordinating Board staff conducted a workshop for 33 Sponsored Programs officers to demonstrate a new electronic submission system for pre-proposals and Notices of Intent to Submit a Proposal. The Sponsored Programs officers= response was favorable overall, and their comments and suggestions were invaluable in helping improve development of the electronic system. With this system, investigators would create and track the progress of their submissions through the Coordinating Board=s web site. The Coordinating Board adopted the program announcement proposed by ACORP at its April 1999 meeting. After adoption, the program announcement was available on the Coordinating Board=s web site. Table 2 Preliminary Allocations Advanced Research Program Biological Sciences Chemistry Computer Sciences Earth Sciences Engineering Materials Science Mathematics Physics Social and Behavioral Sciences $ 6,700,000 2,200,000 1,700,000 900,000 3,700,000 1,500,000 700,000 1,500,000 1,000,000 Advanced Technology Program Aerospace Agriculture/Aquaculture/Agricultural Biotechnology Biomedicine Computer and Information Engineering Energy Environmental Science and Engineering, Recycling, and Water Resources Manufacturing Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications Transportation 3 1,600,000 4,500,000 6,500,000 3,200,000 3,200,000 4,500,000 3,600,000 3,800,000 4,200,000 2,300,000 1,800,000 600,000 In spring 1999, Coordinating Board staff conducted a series of 10 briefings at campuses throughout the state, as well as televised briefings transmitted to 26 additional campuses. In addition, over 5,000 copies of the program announcement and 71 copies of a videotaped briefing were distributed to Texas institutions of higher education. In 1999, an experimental Apre-proposal@ review procedure was used to improve the quality of review and reduce the number of full proposals evaluated by the biological sciences review panels in the Advanced Research Program and the biomedicine and medical biotechnology review panels in the Advanced Technology Program and the ATP Development and Transfer Program. In past competitions, these research areas have received far more proposals than could be funded. Typical success rates for proposals submitted to the biological sciences and biomedicine research areas were 6 to 11 percent. In addition to improving the quality of the review process, the experimental pre-proposal process decreased the amount of time investigators spend developing full proposals with little hope of funding. By June 3, the Board received 1,117 pre-proposals in the biological sciences, biomedicine, and medical biotechnology areas. Each pre-proposal specified a research area, project title, keywords, estimated budget, and brief discussion of the project=s goals and processes, staff, facilities and resources available, and student education and training opportunities. The pre-proposals were reviewed electronically and 507 were selected for full proposals. By the August 13 deadline, investigators at 37 institutions had submitted 490 full proposals. By June 8, the Board received 1,979 Notices of Intent to Submit a Proposal for other research areas. Each notice specified a particular program research area and provided a project title, key words, and a technical abstract for a prospective proposal. The notices were used to estimate the number and specialties of individuals needed to serve as reviewers. By the July 13 deadline, investigators at 51 Texas institutions had submitted 1,744 proposals. The Peer Review Process To review proposals, 148 experts were organized into 15 panels. The chairs (see Table 3) and panelists were recruited from academia, national laboratories, and U.S. and Texas companies. No panelists were associated with any Texas university. The majority were from outside Texas and had not served previously. A list of reviewer affiliations is provided in Appendix A. The review criteria for the ARP proposals included the merit and soundness of the proposal, capability of the investigator(s) to perform the necessary research, adequacy of institutional commitment and resources, and potential positive effect on the infrastructure of science and engineering. In addition to those criteria, the ATP proposals were also evaluated on their prospects for commercialization, leveraging of grant funds to attract external funds, technology transfer, and meaningful industrial collaboration. Criteria for evaluating ATP Technology Development and Transfer proposals were the technical merit and soundness of the proposal, personnel, and physical resources available to the project, and the technology transfer plan. The proposal evaluation forms in Appendix F outline the evaluation criteria in more detail. 4 The Texas Legislature mandates that no more than 70 percent of the funds may be awarded to institutions in The University of Texas System and the Texas A&M System. Adjustments were made by Coordinating Board staff using priorities established by the panels to ensure that limit. To satisfy the 70 percent mandate, the 21 next-highest ranked proposals from non-UT/A&M system institutions were added to the 389 proposals initially selected by the review panels. Final allocations for the 410 proposals selected for funding were reviewed by ACORP. Table 3 1999 Review Panel Chairs Donald Robert Brown ....................................... Professor Emeritus of Psychology, University of Michigan Slade Cargill, III ....................................... Professor of Materials Science and Metallurgy, Lehigh University Jan Christian ......................................................... Associate Professor of Cell and Developmental Biology, Oregon Health Sciences University W. David Constant ....................................... Professor, Louisiana State University and Executive Director, Civil and Environmental Infrastructure Research Center Carl D. Crane, III ......................................... Professor of Mechanical Engineering, The University of Florida Ronald Evans ............. Kerr McGee Professor Emeritus, School of Petroleum and Geological Engineering, University of Oklahoma Ron Gyurcsik ........................... Director of Analog/Mixed-Signal Design Center, Cadence Design Systems Carey, North Carolina Tim Hallman ............................................................. STAR Group Leader, Brookhaven National Laboratory Thomas C. Henderson .................................................. Professor of Computer Science, University of Utah David Hoffman ................................................................ Professor of Chemistry, Iowa State University and Division Director for Science and Technology, Ames Laboratory, Department of Energy Michael Meyer .............................. Professor and Chair of School of Civil and Environmental Engineering, Georgia Institute of Technology Fred Owens ......................................... Senior Rumen Function Physiologist, Optimum Quality Grains, LLC Des Moines, Iowa Gerald Sonnenfeld................................................... Professor and Chair of Microbiology and Immunology, Morehouse School of Medicine Craig Stevens.................................................................................... Associate Professor of Pharmacology, Oklahoma State University College of Medicine Nitish Thakor..................................... Professor of Biomedical Engineering, Johns Hopkins Medical School 5 In October 1999, the Advisory Committee on Research Programs recommended, based on the results of the peer review process, specific projects to the Coordinating Board for funding. In January 2000, the Advisory Committee on Research Programs recommended three additional awards from funds returned by institutions. The three awards were approved by the Commissioner of Higher Education, under the direction of the Coordinating Board. In April 2000, the Advisory Committee recommended and the Commissioner approved three additional awards. Summary of the 1999 Advanced Research and Advanced Technology Program Awards The $58,873,654 appropriated for these research grant programs, plus an additional $2,190,437 carried forward from the previous ARP/ATP awards, was distributed as recommended by the review panel chairs. A total of 415 proposals received funding B 176 Advanced Research Program proposals, 216 Advanced Technology Program proposals, and 23 Advanced Technology Program Development and Transfer proposals. The average award was $147,142. Two or more higher education institutions collaborated on 57 projects, and 26 of the collaborations included a public institution reporting less than $8 million in total research and development expenditures for 1998. A listing of the specific projects, principal investigators, institutions, and amounts awarded appears in Appendix C. Texas-Mexico Border Region The 76th Texas Legislature expressed interest in providing funding for projects that address environmental issues on the Texas-Mexico border. Review panels were directed to place special emphasis on those projects. The Environmental Science and Engineering review panel dedicated more than $1.2 million, or more than a quarter of the total environmental sciences funding allocation, to five highly ranked border projects. One of the projects, AMulti-Purpose Water Management Technology for the Texas-Mexico Border@ was funded at more than one-half of a million dollars and involves five institutions. It was the largest project in terms of dollars and the second largest in terms of number of participating institutions funded by the review panels in the 1999 competitions. Border projects selected by the Environmental Science and Engineering review panel include: AMulti-Purpose Water Management Technology for the Texas-Mexico Border@ ($550,000) by Hanadi Rafai of the University of Houston, Philip Bedient of Rice University, Andrew Ernest of Texas A&M University B Kingsville, Sushma Krishnamurthy of Texas A&M International University, and William Berg of The University of Texas at Brownsville ANovel Caged Crown Ligands for Waste Remediation: Toxic Heavy Metals in the Rio Grande River@ ($221,720) by Jennifer Brodbelt of The University of Texas at Austin and Alan Marchand of the University of North Texas AField Scale Evaluation of Phytostabilization for Closure of Waste Impoundments@ ($198,031) by Raymond Loehr of The University of Texas at Austin ADeveloping Portable Integrated Membrane Systems for Producing Drinking Water in Texas Border Areas@ ($149,760) by D. Clifford and S. Chellam of the University of Houston AEvaporative Cooling Systems on Indoor Air Quality@ ($115,489) by Wen-Whai Li of The University of Texas at El Paso 6 Border projects funded by other review panels include: AEvaluation of Rio Grande Wildlife Corridor Revegetation Efforts@ ($73,213) by Frank Judd and Robert Lonard of The University of Texas-Pan American AInfant Health in the Texas Border Region@ ($71,414) by Todd Jewell and Jeffrey Rous of the University of North Texas AMicrobial Pathogens and Multi-Drug Resistant Bacteria in Irrigation Water and on Vegetables@ ($235,000) by Suresh Pillai and Steven Ricks of the Texas Agricultural Experiment Station and Keith Sternes of Sul Ross State University Biennial Evaluations of the Advanced Research and Advanced Technology Programs The legislation creating the Advanced Research and Advanced Technology Programs specifies that the Coordinating Board appoint a committee consisting of representatives of higher education and private research organizations to evaluate the programs= effectiveness every two years. The programs were last evaluated in fall 1998 by a committee appointed by Coordinating Board Chairman Leonard Rauch. The committee reviewed documentation associated with the programs and met with representatives of the Governor=s Office, the Legislative Budget Board, the office of the Speaker of the House, project investigators, institutional administrators, reviewers, industry representatives, and representatives of the Advisory Committee on Research Programs (ACORP). Dr. Gregory R. Reyes, chair of the evaluation team and Vice President of Biological Research, Infectious Diseases and Oncology for the Schering-Plough Research Institute, reported the evaluation committee=s findings to the Coordinating Board at its January 1999 meeting. The evaluation committee was impressed with the enthusiastic response and uniformly positive input from faculty, grants administrators, and industry collaborators. They found that the overall impact of these programs has been significant in securing additional funding from more traditional sources (National Institutes of Health and National Science Foundation), establishing new high technology business ventures, and training the requisite personnel for these new enterprises. The committee recommended the development of objective measurements of performance or metrics for the programs, strengthening industry interactions, and reconsideration of triaging to limit proposal submissions to the competitions. In response to the last recommendation, a pilot pre-proposal review procedure was used in the 1999 grant cycle to reduce the number of full proposals going to four research areas that received very large numbers of proposals in past competitions. Acknowledgments The Advisory Committee on Research Programs and its chair, Dr. Norman Hackerman, continue to make important and vital contributions to the success of these efforts. In addition, scientists and engineers at Texas higher education institutions ensure the quality of the program through the submission of more excellent proposals than can be funded. 7 Appendix A Affiliations of Review Panelists Texas Industry Institutions BetaGene Electric Power Research Institute Equilon Exxon Co., USA GeneScreen, Inc Huntsman Corporation IBM Austin Research Laboratory (2) Litton TASC Lockheed Martin (2) Mobil Exploration and Producing Technical Center Motorola, Inc. (2) National Semiconductor Corp. Pennzoil Energy Raytheon Systems Co. SBC TRI SESACO Shell Chemical Company SRC/SEMATECH Tanox, Inc. Texas Eastman Chemical Co. Texas Instruments (3) Veridian Arizona State University Auburn University Carolinas Medical Center (2) Columbia University Desert Research Institute - Reno Duke University (3) Duke University Medical Center Emory University Georgia Institute of Technology (2) Illinois Natural History Survey Indiana University Iowa State University (3) Jacksonville State University Johns Hopkins Medical School Kansas State University Lehigh University Louisiana State University (2) Massachusetts General Hospital Michigan State University (2) Mississippi State University (2) Morehouse School of Medicine New Mexico State University - Las Cruces North Carolina State University (2) Northeastern University Northwestern University (2) Oklahoma State University (3) Oklahoma State University College of Medicine Oregon Health Sciences University Rensselaer Polytechnic Institute Roswell Park Cancer Institute(2) Rutgers University San Jose State University Southwest Research Institute St. Louis VA Medical Center State University of New York at Buffalo (2) Tulane University University of Buffalo University of Arizona (2) University of Arkansas University of California - Berkeley University of California at Santa Cruz University of Florida (2) University of Georgia - Athens University of Illinois at Chicago University of Illinois - Urbana Champaign University of Iowa University of Kentucky University of Louisville School of Medicine (2) University of Maryland University of Masschusetts - Amherst (2) University of Michigan (3) University of Michigan Medical School University of Minnesota U.S. Industry Biocryst Pharmaceuticals, Inc. Cadence Design Systems Celera Genomics Cotton, Incorporated Genzyme Corporation Glaxo Wellcome (2) Hewlett Packard Laboratories Novartis Seeds Optimum Quality Grains, LLC Schering-Plough Research Institute Sugen Pioneer Hi-Bred The Dow Chemical Company Government Affiliation Argonne National Laboratories (2) Brookhaven National Laboratory Kitt Peak National Observatory Lawrence Berkeley National Laboratory Lawrence Livermore National Laboratory (3) NASA National Institutes of Environmental Health Sciences, NIH Office of Solar Power, Biopower, and Hydrogen Techology, DOE Sandia National Labs A-8 University of Missouri - Rolla University of Nebraska Medical Center University of Nebraska - Lincoln (3) University of North Carolina - Greensboro University of North Carolina - Charlotte University of Oklahoma (3) University of Oregon University of Rhode Island University of Tennessee - Knoxville University of Utah University of Utah Medical Center University of Virginia Health Sciences Center University of Washington Vanderbilt University Medical Center Virginia Commonwealth University Virginia Piper Cancer Institute Weill Medical College of Cornell University A-2 Appendix B Proposals Submitted by Research Area Number Advanced Research Program Biological Sciences - All Other Biological Sciences - Molecular Biology and Genetics Chemistry Computer Science Earth Sciences Engineering - All Other Engineering - Electrical and Electronics Materials Science Mathematics Physics and Astronomy Social and Behavioral Sciences Advanced Technology Program Aerospace Agriculture/Aquaculture/Agricultural Biotechnology Biomedicine Computer and Information Engineering Energy Environmental Science and Engineering Manufacturing Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications Transportation ATP Development and Transfer Aerospace Agriculture/Aquaculture/Agricultural Biotechnology Biomedicine Computer and Information Engineering Energy Environmental Science and Engineering Manufacturing Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications ATP Totals GRAND TOTALS Submitted 324 Submitted 334 Dollars Requested 51,901,293 101 69 58 191 90 74 89 81 88 1,499 54,607,383 15,589,645 10,789,739 6,675,853 26,075,360 13,624,460 11,786,874 5,422,820 9,721,797 9,861,179 $216,056,403 33 157 260 84 124 166 70 99 184 48 38 29 1,292 5,172,415 26,793,624 60,910,119 14,339,768 20,418,439 29,406,972 10,979,471 17,598,252 35,263,685 8,981,015 5,755,081 3,412,328 $239,031,169 1 5 10 5 12 7 10 5 5 6 4 70 223,594 880,162 2,491,930 1,256,700 2,692,818 1,661,570 2,113,908 1,306,544 1,295,180 1,145,073 785,965 $15,853,444 1,362 $254,884,613 2,861 $470,941,016 Appendix C List of Funded Proposals Advanced Research Program Biological Sciences ............................................................................................................................C-2 Chemistry ...........................................................................................................................................C-4 Computer Sciences ............................................................................................................................C-4 Earth Sciences ...................................................................................................................................C-5 Engineering ........................................................................................................................................C-5 Materials Science ............................................................................................................................... C-6 Mathematics .......................................................................................................................................C-7 Physics and Astronomy......................................................................................................................C-7 Social and Behavioral Sciences ........................................................................................................C-8 Advanced Technology Program Aerospace ........................................................................................................................................C-10 Agriculture/Aquaculture/Agricultural Biotechnology ........................................................................C-10 Biomedicine ......................................................................................................................................C-11 Computer and Information Engineering ...........................................................................................C-12 Energy ..............................................................................................................................................C-13 Environmental Science and Engineering, Recycling and Water Resources ..................................C-14 Manufacturing Technology ..............................................................................................................C-15 Materials Technology .......................................................................................................................C-16 Medical Biotechnology .....................................................................................................................C-16 Microelectronics ...............................................................................................................................C-17 Telecommunications ........................................................................................................................C-18 Transportation ..................................................................................................................................C-18 Advanced Technology Development and Transfer Aerospace ........................................................................................................................................C-19 Agriculture/Aquaculture/Agricultural Biotechnology ........................................................................C-19 Biomedicine ......................................................................................................................................C-19 Computer and Information Engineering ...........................................................................................C-19 Energy ..............................................................................................................................................C-19 Environmental Science and Engineering, Recycling and Water Resources ..................................C-19 Manufacturing Technology ..............................................................................................................C-19 Materials Technology .......................................................................................................................C-20 Medical Biotechnology .....................................................................................................................C-20 Microelectronics ...............................................................................................................................C-20 Telecommunications ........................................................................................................................C-21 C-1 Advanced Research Program 1999 Funded Projects Biological Sciences Digital Biodiversity - The Flora of Texas Project $50,374 Texas A&M University Hugh Wilson $58,597 Texas Agricultural Experiment Station Stephen L. Hatch $76,831 Texas Engineering Experiment Station John J. Leggett $72,457 UTexas at Austin Beryl B. Simpson $55,232 Angelo State University Bonnie B. Amos $50,275 Southwest Texas State University David E. Lemke Evaluate IGFBP2 Pathways in Glioma with Tissue-Specific Transgenic Mouse Model $237,600 UT M.D. Anderson Cancer Center Wei Zhang; Eric Holland Rational Drug Design of Chitinase Inhibitors to Prevent Malaria Transmission $219,340 UT Medical Branch at Galveston Joseph Vinetz; Robert Fox Molecular Genetic Characterization of a Novel RING Finger Protein Implicated in Neoplasia $203,400 UT M.D. Anderson Cancer Center Ann Killary SNooP B A Directed Search for Genetic Variation $198,000 UT Southwestern Medical Center at Dallas Harold Garner; John Minna The Pathogenesis of Breast Cancer Brain Metastasis $175,050 UT M.D. Anderson Cancer Center Janet Price Neuronal Transplantation for the Treatment of Achalasia and Other Neurodegenerative GI Disorders $172,040 UT Medical Branch at Galveston Pankaj Pasricha; Maria Micci Enhancing the Efficiency of Homologous Recombination in Primary Mammalian Fibroblasts $171,090 Texas Agricultural Experiment Station Jorge Piedrahita; Patrick W. Dunne Role of NF-kappa B as an Oxygen-Regulated Switch in Developmental Induction of SP-A Gene Expression $168,960 UT Southwestern Medical Center at Dallas Carole Mendelson Novel roles for Defensins in the Cornea $162,053 University of Houston Alison McDermott Quantitative Whole-Genome Analysis of Chromatin Structure and DNA-Protein Interactions in Yeast $158,100 Texas Agricultural Experiment Station Michael P. Kladde; Michael Polymenis Designer Protein Synthesis via Novel Enzyme Engineering $158,049 University of Houston Susan Martinis; James M. Briggs In Vivo Analysis of Dynamic Gene Expression in Zebrafish $156,367 University of Houston Gregory Cahill A Functional and Spatial Map of the Drosophila Olfactory System * $156,103 UT Southwestern Medical Center at Dallas Dean Smith Functional Genomics Analysis of Meristem Formation and Maintenance $153,850 Texas A&M University Terry Thomas; Alan E. Pepper SCF-mediated Regulation in Arabidopsis thaliana $153,472 UT at Austin Mark Estelle Protein Translocation across and Integration into Mitochondrial Membranes $150,051 Texas A&M University System HSCenter Arthur E. Johnson Positional Cloning of Genes Mediating Susceptibility to Autoimmunity $149,364 UT Southwestern Medical Center at Dallas Edward Wakeland Fibrosis and Anemia: A TGF-beta Transgenic Rat Model $145,042 UT Southwestern Medical Center at Dallas Robert Hammer;J.A. Richardson Tracing the Origin of the Salmonella Enteritidis Epidemic $141,838 Texas A&M University System HSC Andreas Baumler Novel Regulation of Cyclic AMP by Relaxin via Tyrosine Kinase Action $141,390 UT HSC at Houston Carmen Dessauer; Barbara Sanborn, Photoreceptors That Set the Cyanobacterial Circadian Clock $140,712 Texas A&M University Susan Golden * This grant was declined to accept an American Heart Association grant instead. C-2 Molecular Mechanisms of Hepatitis C Virusresistance to Interferon Therapy $139,315 UT Southwestern Medical Center at Dallas Michael Gale Molecular Bases for Isoniazid Activation and Resistance in Mycobacterium Tuberculosis $138,400 University of Houston Shiao-Chun Tu Genetic Dissection and Positional Cloning of Loci for Obesity in Mice $138,258 UT Southwestern Medical Center at Dallas Howard Gershenfeld Bacterial Gene Expression during Pathogenesis: Gene Regulation and Novel Virulence Properties $136,000 UTMB at Galveston David Niesel; David Watson Neural Stem Cells: Controlling Proliferation and Differentiation $135,520 UT Southwestern Medical Center at Dallas Jane Johnson The Generation of Toxin and IL-2 Mutants Lacking a Disintegrin-Like Motif $135,000 UT Southwestern Medical Center at Dallas Roxana Baluna; Ellen S. Vitetta Functions of Histone Acetyltransferases in Mammalian Development $134,800 UT M.D. Anderson Cancer Center Sharon Roth Selective Tissue Accumulation of Liposomes during Altered Vascular Permeability $131,323 UT HSC at San Antonio Linda McManus; William Phillips Neural Ensemble Recordings from Multiple Sites in the Hippocampal Formation $126,571 UT HSC at Houston James Knierim Regulation of Microbial Cellular Differentiation $126,474 Texas A&M University James Golden Molecular Modeling of Membrane Protein Structures $123,376 UTMB at Galveston Werner Braun Molecular Mechanisms Governing the Rhythmic Expression of Cryptochrome, a Blue Light Receptor Gene $119,200 University of Houston Paul Hardin Manipulating Recombination for Gene Targeting, Novel Site-Specificities and Selective RNA Cleavage $115,280 UT at Austin Makkuni Jayaram Kinetics of Serotonin Uptake in vivo in Mice with Genetic Alterations of the Serotonin Transporter $115,245 UT HSC at San Antonio Lynette Daws; Alan Frazer Can Cannabinoid Antagonists Block the Addictive, But Not Analgesic, Actions of Opioids? $111,056 University of Houston Kelly Standifer; Amruthesh Shivachar RGS Protein Function and Specificity in Dictyostelium Development $109,565 UT HSC at Houston Dale Hereld The Role of Mutagenic DNA Repair in the Adaptation of Bacterial Plasmids to their Hosts $109,368 Texas Agricultural Experiment Station George W. Sundin Agonist-Directed Trafficking: A Novel Concept for Drug Selectivity $109,055 UT HSC at San Antonio William Clarke; Kelly Berg Modulating Biological Membrane Fusion: Design of Helix-Binding Receptors with Protease Activity $108,000 UT at Dallas Gregg Dieckmann Slow Inactivation of Dendritic Na Channels: Novel Therapeutic Target for Anti-Epileptic Agents $107,832 University of Houston Costa Colbert Microsatellite Analysis of Attwater's Prairie Chickens $48,550 Tarleton State University Philip Sudman $54,200 Texas Tech University Robert J. Baker Embryonic Environmental Influences on Development of Vertebrate Cardiovascular Physiology $99,040 University of North Texas Warren Burggren Stethorus (Coleoptera: Coccinellidae) Biodiversity in the Texas High Plains $93,280 Texas Agricultural Experiment Station Jerry Michels; Debra Fritts Towards a Safer State Blood Supply $90,900 Texas Agricultural Experiment Station Sumana Datta Apoptotic Gene Expression under Hypoxia Stress $86,064 UT HSC at San Antonio Zheng Dong Oxidation of Host Site Amino Acids in Transmembrane Alpha Helical Peptides $58,930 Texas Woman's University Michael Merchant $15,021 Texas A&M University System HSC J. Martin Scholtz Evaluation of Rio Grande Wildlife Corridor Revegetation Efforts $73,213 UT - Pan American Frank Judd; Robert I. Lonard C-3 Identification of Meteorological Cues that Elicit Fire Ant Mating Flight $56,950 Texas A&M University $0 Texas Agricultural Experiment Station Suojin Wang Jianbo Li Chemistry Anion Sponges $118,000 UT at Austin Jonathan Sessler $57,000 UT at San Antonio John V. McClusky RNA Structure, Metal Sites, and Dynamics Using Site-Specific Isotopic Labels $101,700 Texas A&M University Victoria DeRose $72,810 Texas Agricultural Experiment Station David P. Giedroc Structural and Functional Models of Catalytic Active Sites $156,640 Texas A&M University Marcetta Darensbourg; Donald Darensbourg Multiscale Simulations of Rubber Composites $144,000 University of Houston Bernard Pettitt; Roland Glowinski Using Molecular Probes to Study Protein-Ligand Interactions $142,200 UT at Austin Stephen Martin Single Molecule Identification Using Surface-Enhanced Raman Spectroscopy $140,800 UT at Austin Alan Campion The Workman-Reynolds Effect at the Ice Interface: From Thunderstorm Electricity to Cryoprotection $135,000 University of Houston Anthony Haymet Novel Approaches to Bioactive Aminoimidazole Natural Products $130,680 UT at Arlington Carl Lovely Light Energy Storage in Mesoporous Silica and Silicoaluminophosphate Materials $128,000 University of Houston Larry Kevan Chemical and Structural Studies of Covalent Metal DNA Adducts $121,440 Texas A&M University Kim Dunbar Vibrational Dynamics in Microconfined Liquids $118,358 Texas Tech University Edward Quitevis Chemical Studies of Enzymes $109,120 UT at Arlington Edward Bellion Development of Adaptive Mesh Based Methods for Quantum Dynamical Calculations $102,400 University of Houston Eric Bittner Investigation of Atmospheric Hydrocarbon Oxidation Reactions Relevant to Regional Air Quality $91,696 Texas A&M University Simon North; Renyi Zhang Determination of the Structure of 2-(2=-Hydroxyphenyl)Benzenesulfinate Desulfinase $69,000 Southwest Texas State University Linette Watkins $22,600 UT at Austin Jon Robertus Room Temperature Ionic Liquids--Novel Media for Chemical Separations $89,700 Texas Tech University Richard Bartsch Long-Range Asymmetric Induction Reactions $81,963 UT at Austin Philip Magnus Environmental Chemistry of Aged Contaminants in Soil $69,600 Texas Tech University Todd Anderson Computer Sciences Motion Estimation and Control Algorithms for Robotically Assisted Surgery $184,002 University of Houston Ioannis Kakadiaris; Karolos Grigoriadis $44,616 UT HSC at Houston George Zouridakis Haptic Breast Biopsy Simulation with Patient Specific Data $160,000 Texas Tech University Bharti Temkin $20,000 Texas Tech University HSC Sammy Deeb The METABuffer: Combining Realtime Parallel Graphics VR Display $161,040 UT at Austin Donald Fussell; Chandrajit Bajaj Programming Models for Wireless-based Nomadic Application Systems $146,286 UT at Austin James Browne Integrated Approaches to Digital Hardware Verification: Theory and Tools $133,760 UT at Austin Adnan Aziz; E. Allen Emerson C-4 Design and Analysis of Combinatorial Algorithms $123,318 UT at Austin Vijaya Ramachandran C0PE: Consistent 0-Administrator Personal Environment $120,638 UT at Austin Michael Dahlin; Lorenzo Alvisi 3-D Cellular Automata Models for Tissue Engineering and their Parallel Implementation $111,744 University of Houston Pauline Markenscoff A Temporal Object Query Language and an Optimization Framework $109,120 UT at Arlington Leonidas Fegaras; Ramez Elmasri Multiscale Techniques for Model Development for Groundwater Remediation and their Efficient Solution $106,593 Texas A&M University Richard Ewing; Xuejun Zhang Content Based Indexing and Retrieval of Images and Video $105,300 UT at Dallas Haim Schweitzer Optical Psuedo Channels: Using the Optical Layer to Minimize Queing Delays for Real-Time Traffic $101,150 UT at Dallas Andrea Fumagalli Efficient Broadcasting of Compressed Video for Video on Demand Services $87,586 University of Houston Jehan-Francois Paris Earth Sciences Multi-Shooting Method for Stimulating and Acquiring Seismic Data $152,550 Texas A&M University Luc Ikelle Refining the Geologic Time Scale: Integrated Biostratigraphy, Chemostratigraphy, and Sequence Stratigraphy $92,633 UT at Austin Stephen Ruppel $53,622 Southwest Texas State University Lance L. Lambert Contaminants from South Texas Uranium Mines: Environmental Fate from Molecular to Watershed Scales $83,630 Texas A&M University Bruce Herbert $35,501 Texas A&M University - Corpus Christi Patrick Michaud Characterizing Turbulence During Extreme Wind Events $68,757 Texas Tech University Richard Peterson; Xiaoning Gilliam $41,233 Stephen F. Austin State University Gregory Miller Formation and Evolution of Proterozoic Crust in West Texas and Eastern New Mexico $39,488 UT at El Paso Kate C. Miller $55,810 Texas Tech University Calvin G. Barnes Mueller Matrix Imaging: The Consummate Approach to Underwater Object Detection and Identification $74,052 Texas A&M University George Kattawar $15,550 Stephen F. Austin State University William D. Bruton A Cooperative Geophysical Study of Lithospheric Structure in Central Europe $83,864 UT at El Paso G. Randy Keller Investigation to Refine the Application of Geophysical Instruments to Ground Water Problems $70,583 Texas Tech University Harold Gurrola; George Asquith Geochemical Fractionation of Dust at the Surface of a Wind-Eroding Playa $55,125 Texas Tech University Thomas Gill Engineering Phytoremediation of Soils Contaminated by Chlorinated Hhydrocarbons $99,225 Texas Engineering Experiment Station M. Yavuz Corapcioglu $79,425 Texas Agricultural Experiment Station Malcolm C. Drew Vision Enhancement to Improve Early Cancer Detection $143,100 UT at Austin Rebecca Richards-Kortum $27,900 UT M.D. Anderson Cancer Center Ann Gillenwater The Development of a Novel Room-Temperature Electrically-Induced Resistance Effect in CMR Films $169,100 University of Houston Shangqing Liu Multigigahertz Super-Electrooptic Light Modulation $154,880 Texas Engineering Experiment Station Ohannes Eknoyan; Henry F. Taylor Flexible, High Speed Electro-Optic Modulator $154,440 UT at Dallas Dale Byrne Voxel-Based Haptic Modelling for Laparascopic Surgery Simulation $149,774 UT at Arlington Venkat Devarajan C-5 Low Damage, High Density Plasma Etching Studies for Single-mode, Mid-Infrared Lasers $144,900 University of Houston J. C. Wolfe; C. Horton Behavior of Natural Gas Hydrates in Porous Media $141,845 Texas Engineering Experiment Station Yuri Makogon Pulsed-Laser Interaction with Nanoparticles on a Solid Surface: Removal and Manipulation $141,780 UT at Austin Dongsik Kim Nitric Oxide Removal from Exhaust Gases Using Augmented Gas-Phase and Catalyst Technologies $141,680 Texas Engineering Experiment Station Jerald Caton The Role of Rate-Limited Mass Transfer in Surfactant Enhanced Aquifer Remediation $139,400 UT at Austin Mojdeh Delshad; Gary A. Pope Enhanced Transmissions of Light Through Tissue for Diagnostic and Therapeutic Applications $133,450 UT at Austin A. J. Welch In Situ Ion-Exchange/Biological Removal of Perchlorate from Groundwater $131,680 University of Houston Deborah Roberts; Dennis Clifford Advanced Annealing Strategies for Ultra-Shallow Junctions $131,087 UT at Austin Sanjay Banerjee Development of Forced Convection Micro Heat-Spreaders $127,980 Texas Engineering Experiment Station Ali Beskok; Robert Lucht Synchronous-Illumination Lock-In Detection of Phonon-Tagged Photons for Imaging Biological Tissues $125,588 Texas Engineering Experiment Station Lihong Wang Intelligent (Smart) Concrete-Polymer Composite Materials $124,080 UT at Austin David Fowler; Mircea D. Driga The Effects of Implant Surface Composition on Cellular Biomechanical Characteristics $123,575 UT HSC at San Antonio Daehwan Shin Multi-Scale Analysis Theory and Applications to Chemical Engineering Processes $115,740 UT at Austin Joe Qin Beam Delivery Configuration for Treatment of Irregularly Shaped Targets $82,806 Texas Agricultural Experiment Station Rosana G. Moreira; M. Elena Castell-Perez $30,772 Texas Engineering Experiment Station Leslie A. Braby Oscillatory Networks for Classification $112,307 University of Houston Ben Jansen Joint Source-Channel Coding for ad hoc Networks $105,597 UT at Dallas Aria Nosratinia; Kamran Kiasaleh A Reduced Order Model of Unsteady Flows in Turbomachinery $100,889 Texas Engineering Experiment Station Paul Cizmas Error Estimation and Adaptive Numerical Modeling of Unbounded Domains $98,330 UT at Austin John Tassoulas Smart Sandwich Composite Pipes for Corrosive Resistance, Durability and Rapid Installation $96,600 University of Houston Cumaraswamy Vipulanandan A New Approach for Modeling Fracture in Ductile Solids $95,427 Texas Engineering Experiment Station David Allen Long-Term Multiaxial Durability and Life Prediction of Polymer-Matrix Composites with Aging and Damage $90,000 University of Houston Su Su Wang Engine Friction Reduction for Improved Fuel Economy and Wear $89,228 UT at Austin Ron Matthews; S.P. Nichols Shock Physics Simulation for Aerospace Engineering Design $87,278 UT at Austin Eric Fahrenthold A New Framework for the Run-Time Engine for Discrete-Event Simulation $83,970 Texas Engineering Experiment Station Bryan Deuermeyer Investigation of a Non-Intrusive Method to Detect Defects in Metal Pipelines $72,400 Texas Tech University Klaus W. Zieher Monte Carlo Sampling Methods for Time-Dynamic Stochastic Optimization Models $57,728 UT at Austin David Morton Materials Science Self-assembly Growth of Oriented Organic Thin Films and Nanostructures by Molecular Beam Deposition $219,769 University of Houston Chengzhi Cai; Scott Perry C-6 Improvement of Performance of Thermoplastic Polymers and Thermosets by Addition of Fluoropolymers $96,800 University of North Texas Witold Brostow $96,240 Southwest Texas State University Patrick E. Cassidy Novel Laser and X-ray Surface Scattering from Functional Materials with Structural Transformations $188,200 University of Houston Simon Moss; Lowell Wood Mechanical, Chemical and Electrical Properties of Nanoscale Strucutres . $174,780 UT at Austin Angela Belcher; Mike White Implantable Microparticles for Intracellular and Extracellular Glucose Sensing $171,486 Texas Engineering Experiment Station Michael Pishko; Gerard Cote (G,In)(As,N) Strain Balanced Short Period Superlattices $146,200 University of Houston Alex Freundlich Synchrotron Radiation Based Ultrahigh Resolution M-Resolved Photoemission Spectroscopy of Materials $135,000 UT at Austin James Erskine Low Cost Superplastic Ceramics $121,536 UT at Austin Desiderio Kovar; Eric M. Taleff Second Harmonic Spectroscopy of Surface-Adsorbate Systems: Experiment Meets ab initio Theory $100,320 UT at Austin Michael Downer Heteroepitaxial Self-Assembled Quantum Dots for Si-Based Optoelectronics $85,833 UT at El Paso Jeff Drucker Field Emission from Room Temperature Grown Diamond Coated Microtips $66,225 University of North Texas David E. Golden Mathematics Analysis of a Stochastic Host-Parasite Model for Bees and Mites $63,272 Texas A&M University James Matis; Thomas R. Kiffe $25,025 UT - Pan American Ben Onofa Global Topology and Physics from Local Structure $76,075 UT at Austin Charles Radin; Lorenzo Sadun The Numerical Analysis of Stochastic Models in Finance $75,741 Texas Tech University Dean Victory; Edward J. Allen Modeling the Human Muscular Control System $70,203 Texas Tech University W.P. Dayawansa Computational Number Theory $49,360 UT at Austin Fernando Rodriguez-Villegas Adaptive Recursive Filters for Data Mining $44,820 UT at Austin Elmira Popova Multi-Scale Charged Particle Transport and Applications to Sub-micron Semiconductor Models $43,965 UT at Austin Irene Gamba Segregation Analysis in Genetic Epidemiology Using Generalized Estimating Equations $36,950 Texas Tech University Song Yang Multidimensional Continued Fractions and Simultaneous Rational Approximations $35,634 University of North Texas Luca Zamboni Research in Birational Geometry $35,499 UT at Austin Sean Keel The Trace Formula and the Length Spectrum on Nilmanifolds $34,670 Texas Tech University Ruth Gornet Multivariate Wavelet Component Selection in Near-Infrared Calibration Problems $34,325 Texas A&M University Marina Vannucci Modeling Methods for Large Data Sets $34,320 UT at Austin Edward George Occurrence, Frequency, Duration, Size, and Spread of Epidemics in Stochastic Structured Models $33,618 Texas Tech University Linda Allen Mathematical Analysis of Fluid Fingering Problems in Porous Media $17,684 UT at Arlington Jianzhong Su Physics and Astronomy Development of CW Lasers in the Vacuum Ultraviolet $161,458 Texas A&M University C-7 Edward Fry; Robert A. Kenefick Quantum Transport Phenomena in Charge Density Waves $159,000 University of Houston John Miller; Jia-Rui Liu Physics of Kinetic Confinement in Semiconductor Quantum Wells $65,450 University of Houston Terry Golding $71,485 University of North Texas Christopher Littler Search for New Physics via Rare Charm Procceses $113,200 University of Houston Kwong Lau; Joerg Pyrlik Effective Lagrangians Description of Low-energy Quantum Chromodynamics $109,013 University of Houston Carlos Ordonez Stochastic Cooling of Atoms Using Lasers $101,200 UT at Austin Mark Raizen; Toshiki Tajima Study of Metal-Insulator Transition in Manganites with Colossal Magneto-Resistance $99,000 University of Houston Chin-Sen Ting Relativistic Heavy Ion Collisions $96,800 Texas A&M University Che-Ming Ko Nanoparticle Tracking: Normal and Anomalous Diffusion in Liquid Crystal Monolayers $96,750 UT at Austin Josef Kas An Investigation of the Physical Properties of Protoplanetary Disks $95,580 UT at Austin John Lacy; Neal J. Evans Structure and Properties of Bone $95,010 University of Houston Kevin Bassler; Gemunu Gunaratne The Texas Distant Cluster Survey $89,675 UT at Austin Gary Hill The Equilibrium Structure of Galaxies and Clusters in the Cold Dark Matter Cosmology $83,622 UT at Austin Paul Shapiro; Hugo Martel Lithium Isotopes and the Baryon Density of the Universe $56,395 UT at El Paso Verne Smith A Search for Heavy Flavored Baryons and Their Decays $44,000 UT - Pan American Akhtar Mahmood The Isotopic Composition of Argon in the Solar Wind $30,800 Sam Houston State University Russell Palma Social and Behavioral Sciences Play Intervention for Children with Autistic Symptoms $144,000 UT at Dallas Nira Granott Evaluation of Auditory and Speech Perceptual Skills in Subjects with Low Serotonin Levels $100,000 University of North Texas Kamakshi V. Gopal; Raymond G. Daniloff Uninsured Adult Working-Age Population in Tarrant Co.: Access, Cost of Care, and Health Status $77,430 University of North Texas Susan Brown Eve; Kenneth Koelln $12,605 University of North Texas HSC at Fort Worth Fernando M. Trevino $10,115 UT Southwestern Medical Center at Dallas Joane Baumer The Gault Site: Art and Archeology of the Earliest Texans $49,725 UT at Austin Michael Collins; Thomas R. Hester $36,513 Texas A&M University Harry J. Shafer Neural and Biochemical Mechanisms Associated with the Affective/Motivational Determinant of Pain $80,502 UT at Arlington Perry N. Fuchs Lead Exposure and Polydrug Self-Administration $73,482 Texas A&M University Jack Nation Liquor Consumption: The Relative Importance of Different Social Control Devices $72,800 Texas A&M University James Griffin; Badi H. Baltagi A Fuzzy-based Human Reliability Analysis System for Web-based ACLS Training and Performance $76,138 UT - Pan American Jen-Gwo Chen; Miguel Gonzalez Monetary Policy Asymmetry and Bank Portfolio Composition $42,680 Texas A&M University Dennis Jansen $26,220 Southwest Texas State University Ruby P. Kishan Infant Health in the Texas Border Region $71,414 University of North Texas R. Todd Jewell; Jeffrey J. Rous C-8 A Longitudinal Study of Marriage from Mid Life through Old Age $66,900 University of Houston - Clear Lake Linda Bell AI, Psychological and Decision Theoretic Predictors of Child Abuse $63,200 University of Houston Roy Lachman A General Equilibrium Model for Economies with Both Private and Public Ownerships $43,200 Texas A&M University Guoqiang Tian C-9 Advanced Technology Program 1999 Funded Projects Aerospace Control of Pressure Oscillations in Supersonic Fighter Weapons Bays $244,635 UT at Austin David Dolling; Noel T. Clemens Cockpit Data Fusion with Fixed-Base Simulation Validation for Free-Flight Guidance $208,061 Texas Engineering Experiment Station John Painter; John Valasek Ejector-Augmented Pulse Detonation Rocket $201,800 UT at Arlington Donald R. Wilson; Frank K. Lu Optimal Control of Flow Induced Noise $201,317 Rice University S. Scott Collis; Matthias Heinkenschloss Thrust and Exhaust Diagnostics for the Variable Specific Impulse Magnetoplasma Rocket $198,500 University of Houston Edgar Bering A New Sensor Concept for Vision-Based Navigation of Spacecraft, Aircraft, and Robots $191,911 Texas Engineering Experiment Station John Junkins; John L. Crassidis A Novel Benign Technology for the Direct Fixation of Nitrogen Oxides $73,600 University of Houston - Clear Lake Ramiro Sanchez Optimum Design for Hole-Pattern Annular Seals $53,100 Texas Engineering Experiment Station Dara Childs Agriculture/Aquaculture/Agricultural Biotechnology Microbial Pathogens and Multi-Drug Resistant Bacteria in Irrigation Water and on Vegetables $160,168 Texas Agricultural Experiment Station Suresh D. Pillai; Steven C. Ricke $74,832 Sul Ross State University Keith Sternes Role of Production Practices on Microbial Contamination of Cabbage and Cantaloupes $171,000 Texas Agricultural Experiment Station Elsa A. Murano; Gary Acuff $63,000 UT - Pan American Luis Materon Restoration of Rice Transgene Expression by Inactivation of Polycomb Proteins or Methylation $221,452 Texas A&M University Timothy Hall TERMITINATORBDesign of a Structure-Based Biocontrol Agent for Termites $209,720 Texas Agricultural Experiment Station Linda A. Guarino; Edgar Meyer Risk of Salmonella and Campylobacter Contamination of Cattle During Transport to Slaughter $206,284 Texas Agricultural Experiment Station Gary Acuff; Elsa A. Murano Molecular Mapping and Functional Genomics of Sorghum Adaptation to Stress Environment $200,000 Texas Tech University Henry Nguyen Strategic Approaches for Analysis and Manipulation of Genomes and Genes $199,500 Texas Agricultural Experiment Station David M. Stelly; H. James Price Leptospirosis in Texas Cattle and Wildlife $83,750 UT Medical Branch at Galveston Joseph Vinetz $55,000 Texas A&M University A. Konrad Eugster $57,500 Texas Tech University Carleton J. Phillips Genome Technology and Gene Discovery for Texas Agriculture $194,000 Texas Agricultural Experiment Station John E. Mullet; Patricia Klein Genes for Insecticidal Proteins Inducing Mortality and Apoptosis in the Cotton Boll Weevil $186,700 Texas Tech University Shan Bilimoria Parallel Radiation Hybrid Mapping for Isolating Economically Important Genes in Cattle $180,963 Texas Agricultural Experiment Station James E. Womack Vibrio parahaemolyticus and Texas Oysters: Biology and Public Health Significance $180,000 Texas A&M University at Galveston John Schwarz Improved Profitability of Peanut with Multiple Disease Resistance $178,500 Texas Agricultural Experiment Station Charles E. Simpson; James L. Starr Analysis and Field Test of Transgenic Cotton Plants that Express Arabidopsis Antioxidant Genes $175,628 Texas Tech University Hong Zhang; A. Scott Holaday Contributions of Agronomically Valuable Refuges to Integrated Pest Control in Texas Cotton $170,655 Texas Agricultural Experiment Station Kevin M. Heinz; James W. Smith C-10 A Virus-Mediated Plant Expression System for Rapid Purification of Foreign Proteins $162,000 Texas Agricultural Experiment Station Herman Scholthof Development of Stress Tolerant Cotton Seeds $147,000 Texas Tech University Randy Allen; David Tissue Engineering Plant Herbicide Resistance $146,800 UT at Austin Alan Lloyd; Stanley Roux Elimination of Gossypol from Cottonseed via Biotechnology $143,660 Texas Agricultural Experiment Station Chauncey R. Benedict; Clint Magill Candidate Gene for Reproductive Sterility in Pinus Taeda L. $130,000 Texas Agricultural Experiment Station Claire G. Williams Antioxidants and Other Cereal Components for Functional Foods $102,500 Texas Agricultural Experiment Station Lloyd W. Rooney Heat Stress and Production Efficiency at Cattle Feedyards $100,000 Texas Tech University Michael Galyean Native or Naturalized Legumes and Nutritional Supplements for Pasture and Range-Based Goat Nutrition $69,170 Texas Agricultural Experiment Station James P. Muir $29,610 Tarleton State University Timothy F. Brown Molecular Diagnostic Assays for the Detection of Babesia Equi in Horses $92,282 Texas Agricultural Experiment Station Patricia Holman; Judith Ball Peptide Spawning Pheromone for Commercial Oyster Production in Texas $62,540 UT Medical Branch at Galveston Gregg Nagle; Sherry D. Painter $26,906 Texas A&M University at Galveston Sammy M. Ray Value-Enhanced High Oil Corn for Feedlot Cattle $68,521 Texas Tech University Reed Richardson Ocean Freight Futures for Risk Management to Enhance the Global Competitiveness of Texas Ports $49,528 Texas Agricultural Experiment Station Michael S. Haigh; Stephen W. Fuller Dietary Modulation of Health in Morone Hybrids for Increased Production Efficiency in Aquaculture $49,500 Texas Agricultural Experiment Station Delbert M. Gatlin Biomedicine Redesign of a Genetics Tracking Program to Improve Ease of Use and Reduce Errors $188,474 UT HSC at Houston Todd Johnson; Jiajie Zhang $36,526 UT M.D. Anderson Cancer Center Margaret Spitz Polyethlyenimine Gene Therapy Given by Aerosol: A Novel Treatment for Pulmonary Metastases $108,490 Baylor College of Medicine Charles Densmore $116,510 UT M.D. Anderson Cancer Center Eugenie Kleinerman Molecular Classification of Human Gliomas by Gene Expression Profiling $225,000 UT M.D. Anderson Cancer Center Wei Zhang; Gregory N. Fuller Discovery and Development of Src Inhibitors for Treating Ovarian Cancer $225,000 UT M.D. Anderson Cancer Center Raymond Budde; Robert Newman An Orally-Regulable Gene Therapy for Advanced Cancers $225,000 Baylor College of Medicine Bert O'Malley A Strategy to Eliminate the Latent Reservoir of HIV $225,000 UT Southwestern Medical Center at Dallas Ellen Vitetta; Octavio Ramilo A Novel Approach for Myocardial Protection and Revascularization $225,000 UT Medical Branch at Galveston Massoud Motamedi; Marschall Runge A Highly Sensitive Blood Test for Early Detection of Carcinoma Cells $225,000 UT Southwestern Medical Center at Dallas Jonathan Uhr Mouse Models for Human Cardiac Hypertrophy and Heart Failure $225,000 UT Southwestern Medical Center at Dallas Eric Olson Use of Telomerase for the Immortalization of Normal and Pre-Malignant Human Cells $225,000 UT Southwestern Medical Center at Dallas Carmela Morales; Jerry W. Shay Controlling Protein Stability as a Mechanism of Drug Design $224,818 Baylor College of Medicine Stephen Elledge C-11 Rapid Repair of Chronically Severed Spinal and Sciatic Axons in Mammals $102,000 UT at Austin George Bittner; Timothy Schallert $43,000 UT Medical Branch at Galveston Harvey M. Fishman $59,000 Southwest Texas State University Joseph R. Koke $12,000 Huston-Tillotson University Kathy Wylie Schwab Exploring the Phenotypic Traits Associated with the Formation of Candida albicans Biofilms $198,830 UT HSC at San Antonio Jose Lopez-Ribot; Brian L. Wickes Beta Cell Specific Cytotoxicity Using a Rat Insulin Promoter Thymidine Kinase Construct $197,744 Baylor College of Medicine F. Charles Brunicardi; Manas K. Ray Generation of an Expression cDNA Microarray to Study Complex Metabolic Diseases $197,000 UT Southwestern Medical Center at Dallas Jay Horton; Joachim Herz High-Throughput Screening of CNS Signal Transduction Pathways $196,852 Baylor College of Medicine John David Sweatt Tumor Vaccine in Allogeneic Bone Marrow Transplantation $194,000 UT M.D. Anderson Cancer Center Craig Mullen Development of Thromboresistant Vein Grafts by Somatic Gene Transfer $193,149 UT HSC at Houston Pierre Zoldhelyi; James T. Willerson Noninvasive Glucose Sensing with a Novel Optical Technique $192,200 UT Medical Branch at Galveston Rinat Esenaliev; Wayne F. March Ribozyme Treatment for Atherosclerosis $191,000 UT HSC at Houston Ba-Bie Teng New Strategy for a Syphilis Vaccine $183,472 UT Southwestern Medical Center at Dallas Michael Norgard Isolation and Genetic Engineering of Myogenic Stem Cells $181,000 UT Southwestern Medical Center at Dallas Daniel Garry Microarray Analysis of Doxorubicin Cardiomyopathy $180,000 UT Southwestern Medical Center at Dallas Ralph V. Shohet Alteration of FGFR-1 RNA Splicing in Glioblastoma Cells by Antisense Oligoribonucleotides $176,000 UT M.D. Anderson Cancer Center Gilbert Cote; Wei Jin Antimetastatic Therapy by Combined Use of a Novel uPA-derived Peptide (A6) plus Cyclophosphamide $173,100 University of North Texas HSC at Fort Worth Ronald Goldfarb; Richard P. Kitson p202, An Interferon-Inducible Protein, in Cancer Gene Therapy $170,000 UT M.D. Anderson Cancer Center Duen-Hwa Yan Identification of a Gene Essential for Human Tooth Formation $134,467 Baylor College of Medicine Pragna Patel $30,000 UT HSC at Houston Rena D'Souza Lung Radioprotection by Stimulation of Pneumocyte Proliferation with Keratinocyte Growth Factor $160,049 UT M.D. Anderson Cancer Center Nicholas Terry; R. Allen White DNA Based Vaccine Against Melanoma $153,700 University of North Texas HSC at Fort Worth Jerry Simecka Development of Heparin with Enhanced Clinical Efficacy Utilizing HIP Peptide-1 $144,000 Texas A&M University System HSC Magnus Hook Interior Cleavage Fragments of the Retinoblastoma Tumor Suppressor Protein $138,015 UT M.D. Anderson Cancer Center Hong-Ji Xu; Shi-Xue Hu, Development of New Assays for Broad-Spectrum Anti-Microbial Drugs Against Cell Division Proteins $118,000 UT HSC at Houston William Margolin Bifunctional b-Lactamase Inhibitors to Simultaneously Target Serine and Metallo-beta-Lactamases $102,594 Southern Methodist University John Buynak Computer and Information Engineering Validating Secure Network Protocols For Electronic Commerce $179,670 UT at Austin Jacob Abraham $92,366 Southern Methodist University Sukumaran V. S. Nair Architecture Evaluation Using Commercial Workloads $211,750 Texas Engineering Experiment Station Laxmi Bhuyan Geometric Reasoning Methods for Molecular Docking and Computer-Aided Drug Discovery $209,800 Rice University Lydia Kavraki; George Phillips C-12 Distributive Adaptive Network Caching $206,000 University of Houston Jaspal Subhlok; Martin Herbordt NextGen: A Programming Environment for Generic Java $192,104 Rice University Robert Cartwright; Matthias Felleisen Compiling for Energy Efficiency in Embedded Systems $174,567 Rice University Keith Cooper; Devika Subramanian VLIW ASIPs for Embedded Multimedia and Signal Processing Applications $170,240 UT at Austin Margarida Jacome; Gustavo DeVeciana High Performance Multimedia Processors $108,667 UT at Austin Lizy John; Earl Swartzlander $49,133 UT - Pan American Eugene B. John Internet and Component-Based Modeling System for Lake Water Quality and Fish Habitat Projections $76,493 Lamar University Xing Fang; We-Ran Zhang $45,282 University of Houston Theodore G. Cleveland $31,359 Southwest Texas State University Alan W. Groeger DSP Systems Using Wavelet-Based Image Compression for Multimedia $151,760 Texas Tech University Sunanda Mitra; David J. Mehrl Implementation of Automated Multi-Level Substructuring for Industrial Frequency Response Analysis $149,000 UT at Austin Jeffrey Bennighof Speedy Delivery - A New Approach for VLSI and Broadband Packaging Interconnect Design $148,972 UT at Austin Robert Flake Resource Management for Cluster-Based Web Servers $148,696 Rice University Peter Druschel; Willy Zwaenepoel A Library for Network Optimization $143,000 Rice University David Applegate; William Cook A Flexible and Robust Global Data Infrastructure $142,604 UT at Austin Michael Dahlin; Harrick Vin Secured Real-Time Communications in High Performance Networks $79,226 Texas Engineering Experiment Station Wei Zhao; Riccardo Bettati $41,480 University of Houston - Clear Lake Sadegh Davari Support for Adaptive Multi-Criteria Transaction Processing in E-Commerce Applications $117,800 UT at Dallas I-Ling Yen Scan Vector Compression/Decompression for Testing Systems-on-a-Chip $109,880 UT at Austin Nur Touba Telecommunication Software Testing and Quality Assurance $95,672 Southern Methodist University Jeff Tian Dynamic Scene Update in Virtual Environment by Parsing MPEG-4 Video Data and Mapping with 3D Objects $62,500 Texas Engineering Experiment Station Amarnath Banerjee Energy Control System for Advanced, Energy Efficient, and Low Emission Vehicles $231,000 Texas Tech University Micheal Parten; Jon Bredeson Vortex Aluminum Fuel Cell $168,784 University of Houston Hyder Husain $47,600 Texas Southern University Gerald Hill Improved Catalytic Membrane Reactors for Synthesis Gas Generation $185,800 University of Houston James T. Richardson A Novel Five-Phase Electric Motor Drive for Electric/Hybrid Vehicles $185,000 Texas Engineering Experiment Station Hamid Toliyat Numerical Prediction of Flow-Structure Interactions for Designing Deepwater Platforms in the Gulf of Mexico $130,600 UT at Austin John Kallinderis $52,800 UT at San Antonio Anthony T. Chronopoulos Computation of Transport Properties from Petrographic Images $127,000 University of Houston K. K. Mohanty $51,200 University of Houston - Clear Lake L. Shih Next Generation Subsurface Simulator for Distributed Computer Networks $161,426 UT at Austin Mukul Sharma; Steven Bryant C-13 Power System Reliability Analysis Including Dynamics and Control Effects $159,504 Texas Engineering Experiment Station Garng Huang; Chanan Singh Automating Refinery Optimization Using the Adaptive Critics Design $158,700 Texas Tech University James Riggs New Techniques for Maintaining Reliability in the Restructured Electric Utility Industry $156,200 Texas Engineering Experiment Station Karen Butler; B. Don Russell Mechanisms and Kinetics of Gas Hydrate Decomposition $150,000 Rice University Walter Chapman; Joe Hightower A 3-D Forward and Inverse Model for the Virtual Assembly and Deconstruction of Carbonate Platforms $123,322 Texas A&M University Rene O. Thomsen; Steven L. Dorobek Development of Low Cost and Environmentally Benign Electrodes for Rechargeable Lithium Batteries $116,000 UT at Austin Arumugam Manthiram Co-Firing Coal: Biowaste Blends in Boiler Burners $88,200 Texas Engineering Experiment Station Kalyan Annamalai $25,400 Texas A&M University John Sweeten High-Efficiency Shell-and-Tube Heat Exchangers with Porous Baffles $72,240 Texas Engineering Experiment Station Sai Lau; T. Lalk Environmental Science and Engineering, Recycling, and Water Resources Multi-Purpose Water Management Technology for the Texas-Mexico Border $165,986 University of Houston Hanadi Rifai $129,224 Rice University Philip Bedient $138,171 Texas A&M University - Kingsville Andrew Ernest $53,521 Texas A&M International University Sushma Krishnamurthy $63,097 UT at Brownsville William Berg A Portable Remote Sensor for Hydrocarbon Gas Leakage Detection $257,800 University of Houston Han Le Environmental and Industrial Monitoring of Trace Gases with Novel Quantum Cascade Lasers $236,265 Rice University Frank Tittel; Robert F. Curl Surfactant Remediation of Recalcitrant Groundwater Contaminants $234,716 UT at Austin Gary Pope; Russell T. Johns Novel Caged Crown Ligands for Waste Remediation: Toxic Heavy Metals in the Rio Grande River $110,860 UT at Austin Jennifer Brodbelt $110,860 University of North Texas Alan P. Marchand Field Scale Evaluation of Phytostabilization for Closure of Waste Impoundments $198,031 UT at Austin Raymond Loehr Enhancing Efficiency of Ruminant Protein Utilization and Recycling to Minimize Environmental Impact $186,595 Texas Agricultural Experiment Station William C. Ellis $10,000 Texas A&M University James H.Matis Electron-Beam Technology for Remediation of Chemical and Biological Contamination of Water $196,200 Texas A&M University Peter McIntyre Integrated Multifunctional Fluorescence Sensors for Real Time Environmental Effluents and Water Analysis $194,702 University of Houston David Starikov; Nasr-Eddine Medelci Fiber-Based Fourier Transform Raman Spectrometer for Pollutant Detection $193,320 UT at Austin Philip Varghese Thermocatalytic Conversion of Tires, Plastics and Other Organic Materials to Chemical Feedstock $187,974 Texas Engineering Experiment Station James Holste Foam-Enhanced Sweep in Surfactant Subsurface Remediation $155,224 UT at Austin William Rossen; Mojdeh Delshad Super-Porous Titania/NLO-Coated Fiber Optic Photoreactor for Enviornmental Applications $154,000 Lamar University Daniel Chen; Kuyen Li Developing Portable Integrated Membrane Systems for Producing Drinking Water in Texas Border Areas $149,760 University of Houston Dennis Clifford; Shankar Chellam An in situ Catalytic Process for the Remediation of MTBE in Groundwater $140,360 University of Houston William Rixey Experiments and Model Development for Biomass Combustion $135,000 UT at Austin Bill Gardiner C-14 Degradation of Halogenated Aromatic Hydrocarbons in Soils and Sediments $130,904 Texas Engineering Experiment Station Bill Batchelor On-Board Distillation of Gasoline for Decreased Hydrocarbon Emissions from Gasoline Vehicles $126,545 UT at Austin Ron Matthews; Tom Kiehne Mitigation of Heave and Shrinkage Distress of Expansive Soils Using Recycled Waste $58,258 UT at Arlington Anand J. Puppala $58,374 University of North Texas Nandika Anne D'Souza Determining the Impacts of Evaporative Cooling Systems on Indoor Air Quality $115,489 UT at El Paso Wen-Whai Li; Russell R. Chianelli Novel Catalysts and Reactors for Air Pollution Control $110,000 University of Houston Vemuri Balakotaiah Environmentally Safe, Simple and Rapid Disposal of Animal Carcasses by Aerobic Thermophile Digestion $101,650 Texas Agricultural Experiment Station Billy M. Hargis; John Carey Geohazards Associated with Seafloor Erosion on the Continental Slope of the Gulf of Mexico $69,700 University of Houston Seiichi Nagihara Manufacturing Technology Laser Beam Guided by Waterjet in Cutting Thin and Heat Sensitive Materials $83,500 UT at Arlington Heather E. Beardsley $158,436 Southern Methodist University David Johnson Hypervelocity Powder Deposition by Magnetic Flux Compression Devices $223,642 UT at Austin Mircea Driga; Raymond Zowarka Integration of Computer Aided Design and Manufacturing with Computer Simulation of Human Body $210,601 UT Medical Branch at Galveston William Buford; Rita M. Patterson Insertion of Legacy Design and Analysis into a Collaborative Virtual Prototyping Environment $198,658 UT at Arlington Venkat Devarajan; John Mills Study of Mechanical Interactions in Centrifugally Cast Interfaces $171,126 LeTourneau University Yoni Adonyi High Speed Liquid Metal Jetting for Metal Parts and Electronic Interconnects $159,600 UT at Arlington John W. Priest Development of Hybrid Rapid Prototyping Process Based on 3D Welding and CNC Milling $149,152 Southern Methodist University Radovan Kovacevic Reliability in Electronic Packaging: A New Design-Testing Paradigm $145,700 UT at Austin Glenn Masada; Tess J. Moon Behavior of Heat Exchange Fluid Aerosols Leaking from Manufacturing Processes $143,350 Texas Engineering Experiment Station Sam Mannan; Ken D. Kihm Reflow Processes for Flip-Chip Solder Connections $143,000 UT at Austin Ronald Panton Manufacturing Processes for Adhesive Bonding Structural Steel Frames and Panels $142,183 LeTourneau University William Schroeder Dynamic Configuration of Agent-based Decision-Making Systems for Manufacturing Enterprises $134,396 UT at Austin K. Suzanne Barber Scanning SQUID Microscope for Nondestructive Imaging of Subsurface Defects $133,400 University of Houston John Miller; Wu-Pei Su Defect Detection and Prevention in Printed Circuit Board Assembly via Information Integration $124,100 Texas Engineering Experiment Station Daniel Apley Imaging Polarimetry for High-Throughput Screening $123,465 University of Houston Richard Willson Automated Assessment of the Health and Functionality of Machinery $100,888 UT at Austin Benito Fernandez; Michael Bryant Third Party Warehousing for Effective Manufacturing Logistics $100,700 Texas Engineering Experiment Station Chung-Yee Lee; Sila Cetinkaya Broad Modeling of Grinding Thermal Damage for Precision Gear Materials $95,447 Texas Engineering Experiment Station John Mayer; Angie Hill Price PID Controller Design for Industrial Applications: A Novel Approach $87,000 Texas Engineering Experiment Station Aniruddha Datta; S. P. Bhattacharyya Colorimetric and Fluorescent Diagnostics for Industrial Mixing Processes $66,000 UT at Dallas Lynn Melton C-15 X-ray Microtomographic Image Analysis for Identification and Measurement of Cotton Contaminants $64,000 Texas Tech University Hamed Sari-Sarraf; Eric F. Hequet Surface Roughness Quantification of Pharmaceutical Dosage Forms $58,975 Texas Tech University HSC Mansoor Khan A Generic Thermal Signature Library for Circuit Card Inspection $51,124 Texas Engineering Experiment Station Sheng-Jen Hsieh Powder Compaction Mechanisms in Manufacturing of Pharmaceutical Solid Products $30,000 University of Houston Yi-chao Chen; Kamel Salama Materials Technology Preparation and Applications of Derivatized Carbon Nanotubes $325,000 Rice University John L. Margrave Production of Functionalized Fullerene Nanotubes $293,000 Rice University Richard E. Smalley Mechanochemical Synthesis of Nanocomposite Materials for Superior Mechanical and Chemical Behavior $198,820 Lamar University Malur Srinivasan; David L. Cocke Polymer Nanocomposites by Melt Processing $197,000 UT at Austin Donald Paul Ultrathin Gate Dielectric ZrO2 and Zr-Silicate for Advanced Si and SiGe Device Application $196,520 UT at Austin Jack Lee New Materials Technology Research and Development for the Texas Leather Industry $151,040 Texas Tech University Dennis Shelly $39,000 Texas State Technical College Kirk P. Hunter Thermal Resists for Next Generation Electron-Beam Mask Patterning $190,000 UT at Austin Grant Willson Development of High-Resolution Moire Interferometry for Electronic Packaging Applications $190,000 UT at Austin Paul Ho; David R. Kincaid Electromagnetically Induced Transparency and Lasing without Inversion in Rare Earth Doped Compounds $146,500 Texas A&M University Olga Kocharovskaya $38,450 Prairie View A&M University Cleo Bentley Innovative Materials for High Speed Semiconductor Devices $180,000 University of North Texas Richard F. Reidy; Dennis W. Mueller Megatubes and Nanotubes: New Dimensions in the Synthesis and Structure of Carbonaceous Materials $170,000 UT at Austin R. Malcolm Brown, Jr.; Richard Lagow New Bio-Compatible Silicon Electronic Devices for Drug Delivery and DNA Sensing $150,511 Texas Christian University Jeff Coffer Melt Processable Polyaniline: Commercially Important Environmentally Benign Synthesis and Processing $147,300 UT at Arlington Martin Pomerantz Diamond-Silicon Carbide Composites for Drill Bits $137,358 Texas Christian University T. Waldek Zerda Development of Large-Area Nanostructured Carbon Films for Flat Panel Display Applications $127,067 University of North Texas Jose M. Perez Switchable Mirrors Using Metal Hydride Films $118,000 UT at Austin John Markert Medical Biotechnology Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis $221,300 UT at Austin H. Grady Rylander; Thomas Milner Thin Film Optical Microdetectors for Retinal Implantation: A ABionic@ Eye $120,600 University of Houston Alex Ignatiev $97,000 UT HSC at Houston Charles Garcia Targeted Gene Expression in Areas of Low Flow in Vascular Cells $205,118 Rice University Larry McIntire Creating Biosensors from Massively Parallel Addressable Arrays of Planar Supported Biomembranes $202,692 Texas A&M University Eric Simanek; Paul Cremer Development of Multiphoton NSOM for Studying Local Neurotransmitter Kinetics at Individual Synapses $202,000 UT at Austin David Vanden Bout; Jason Shear C-16 High-Throughput Cloning of Restriction Enzymes and DNA Methylases for Medical Diagnostics $126,656 Texas Agricultural Experiment Station Michael Kladde $70,500 Texas A&M University Lisa Campbell Optimization of Antibodies for Use in Biotechnology Research $193,100 UT at Austin Brent Iverson; George Georgiou Steroid Receptor RNA Activator as a Diagnostic/Therapeutic Factor in Endocrine Tissue Malignancies $191,454 Baylor College of Medicine Rainer Lanz; Kent C. Osborne Development of Novel IL-5 Antagonists for Therapy of Allergic Inflammation $191,000 Baylor College of Medicine David Huston; David B. Corry New Strategies for Immune Manipulation $187,474 UT Southwestern Medical Center at Dallas Stephen Johnston An Open Reading Frame Vector for the Isolation of Genes $181,000 UT Southwestern Medical Center at Dallas Irene Rombel Biochip Microarrays Synthesized Using a Novel Photochemistry $176,115 University of Houston Xiaolian Gao Functional Mimics of Tumor Necrosis Factor-Alpha $175,000 Texas A&M University Kevin Burgess; Scott Linthicum Non-Fouling, Timed-Release Antimicrobial Coatings to Combat Implant-Centered Infections $170,000 UT at Arlington Richard Timmons Development of Adenovirus Vector Specifically Replicated in Cancer Cells for Gene Therapy $163,680 Baylor College of Medicine Heshan Zhou; Malcolm Brenner Defined DNA Tertiary Structures for Drug Target Screening $161,168 UT at Dallas Stephen Levene Stochastic Sensing of Medically Relevant Organic Analytes $159,076 Texas A&M University System HSC Hagan Bayley Controllable Neurotrophin Gene Therapy for Age-Associated Memory Impairments $149,800 Baylor College of Medicine Keyi Yang Analysis of Sequence Determinants of Antisense DNA $147,650 UT at Dallas Donald Gray Rapid Screening of Libraries of Genetically Engineered Cells Using Micropatterned Biomaterials $74,492 Texas Engineering Experiment Station Michael Pishko $68,753 Texas A&M University Richard M. Crooks Development of Lysostaphin as a Control Prophylaxis for S. aureus Infections $130,000 UT at Dallas Ronald Yasbin Bacteriophage Genes as the Basis for New Antibiotics $121,957 Rice University Charles Stewart VlsE as an Immunodiagnostic and Immunoprotective Reagent for Lyme Disease $118,000 UT HSC at Houston Steven Norris Microelectronics Novel High-Permitivity Gate Dielectric Materials for Advanced Microelectronics $176,239 University of North Texas Robert M. Wallace; Bruce E. Gnade $120,302 Texas Engineering Experiment Station Wiley P. Kirk Development of Advanced MOS Gate Stack for Deep Sub-100nm CMOS Technology $218,000 UT at Austin Dim-Lee Kwong; Mike White Improving Chemical Mechanical Planarization through Determination of Fundamental Polishing Mechanism $124,673 Southwest Texas State University Heather Galloway $76,272 University of Houston Scott S. Perry Exploring New High Dielectric Constant (High k) Thin Film $185,000 Texas Engineering Experiment Station Yue Kuo UV Raman Studies of Ultrashallow Ion Implantation, Stress, and Alloying in Silicon $178,600 Texas Tech University Mark Holtz Ultra Shallow Junction Formation by Cluster Beam Ion Implantation in Silicon $166,451 University of Houston Wei-Kan Chu High-Power Coherent Arrays of Vertical Cavity Surface-Emitting Semiconductor Lasers $160,894 Southern Methodist University Gary Evans Deposition and Process Integration of Low-k Porous Fluorocarbon ILD Films for ULSI Circuits $151,000 Texas Tech University Shubhra Gangopadhyay; Sindee Simon C-17 High Density Plasma Source Technology $78,805 UT at Dallas Lawrence Overzet; Matthew Goeckner Telecommunications Development of Wideband Vector Channel Models and Testbed for 3rd Generation Wireless Mobile Systems $159,759 UT at Austin Guanghan Xu; Hao Ling $69,648 UT - Pan American Heinrich Foltz High Speed Wireless Local Area Network $205,216 Rice University Behnaam Aazhang; Richard G. Baraniuk Foveated Wireless Video Communication $198,700 UT at Austin Alan Bovik; Brian Evans Routing and Resource Allocation with the Challenge of Mobile Wireless Networks $152,763 Texas Engineering Experiment Station Mi Lu Effective Resource Management for Differentiated Services $96,700 UT at Dallas Biao Chen; SiQing Zheng $52,400 Texas Engineering Experiment Station Wei Zhao Photonic Band Gap Antennas for Wireless Communications $142,000 University of Houston David Jackson Analysis of Group Decision Support Systems and Consensus Building for Electronic Commerce $109,000 Texas Tech University Mario Beruvides; Dean Fontenot Universal Signal Separation for Teleconferencing and Wireless Communications $101,719 Southern Methodist University Scott Douglas Advanced Coding Techniques and Low Complexity Decoding for Wireless Data Networks $72,600 Texas Engineering Experiment Station Krishna Narayanan Transportation A Sensor for Remote Detection of Alcohol Vapors $109,608 UT at Arlington Siamak A. Ardekani; Theresa A. Maldonado $57,892 Texas Christian University Edward S. Kolesar $12,500 Texas Southern University Carol L. Lewis The Design of a New Generation of Traffic Noise Barriers $178,200 UT at Austin David Blackstock Dynamic Optimization of Logistics and Transportation Operations $125,000 UT at Austin Hani Mahmassani; Patrick Jaillet Advanced Control Algorithm Development and Testing for Off-Road Vehicle Active Suspension Systems $120,000 UT at Austin Joseph Beno Development of a Wireless Integrated Moisture Sensor for Pavement Moisture Content Monitoring $114,900 University of Houston Richard Liu; Wallace L. Anderson Transportation System Modeling Using High Level Architecture $100,000 Texas Engineering Experiment Station Robert Shannon Forecasting Traffic Parameters by Classification of Patterns $92,687 Texas Transportation Institute Laurence Rilett; Steve Liu A Multipoint Optical Rolling Wheel Deflectometer $72,804 University of Houston Tony King C-18 Advanced Technology Development and Transfer 1999 Funded Projects Aerospace Smart Structures Technologies in Industrial Environments $175,000 Texas Engineering Experiment Station Match: $100,000 NAL Research Corporation $85,000 Aeroprobe Corporation $40,000 National Instruments Dimitris Lagoudas; Othon Rediniotis Agriculture/Aquaculture/Agricultural Biotechnology Cloning Transgenic Cattle Resistant to Bovine Spongiform Encephalopathy (BSE, Mad Cow Disease) $194,000 Texas Agricultural Experiment Station Mark E. Westhusin; Patrick Dunne Match: $200,000 Ultimate Genetics, LLC Biomedicine A High Resolution Convertible PET Camera for Functional Imaging and Diagnosis $225,000 UT M.D. Anderson Cancer Center Wai-Hoi Wong; Jorge Uribe Match: $420,000 Siemens/CTI, Inc. Commercialization of New Sulfated Cyclodextrins for Electrophoretic Biomedical and Drug Separations $140,000 Texas A&M University Gyula Vigh Match: $140,216 J&W Scientific, Inc. Computer and Information Engineering Large Scale Mixed-Integer Programming $83,000 Rice University Match: $100,000 Compaq Computer Corporation William Cook; Robert Bixby Energy Development of Thick Superconducting Tapes for High Current Applications by Photo-Assisted MOCVD $304,290 University of Houston Pen-Chu Chou $45,710 Sam Houston State University Gan Liang Match: $600,000 Metal Oxide Technologies, Inc. $20,000 Epichem Development of an Industrial Grade Active Filter to Cancel 5th, 7th, 11th, 13th Harmonic Currents $227,000 Texas Engineering Experiment Station Prasad Enjeti Match: $175,000 Current Technology, Inc. $120,000 Lucent Technologies Increased Energy Efficiency from Novel Labyrinth Seals and Discouragers $173,800 Texas Engineering Experiment Station David Rhode Match: $650,000 Pratt & Whitney Environmental Science and Engineering, Recycling, and Water Resources Modeling and Computer Simulation of Environmental Remediation Using Parallel Finite Elements on PC Clusters $247,600 UT at Austin Mary F. Wheeler; Graham Carey Match: $1,000,000 Schlumberger Commercialization of Semiconductor Etch Tool Emission Control Technology $200,000 Texas A&M University John Bevan; Robert R. Lucchese Match: $119,000 Rf Environmental Systems, Inc. $100,000 Motorola $60,000 SEMATECH Manufacturing Technology Laser-Aerosol Manufacturing of Nanoparticle Electronic Materials $125,200 UT at Austin Match: $160,000 The DuPont Company C-19 John Keto; Michael F. Becker An Innovative Management System for End-of-Life Electronic Product Disassembly and Recycling $120,000 Texas Tech University Hong-Chao Zhang Match: $194,800 System Service International, Inc. $30,000 Compaq Computer Corporation Development of Photonic Antenna Technology $100,000 UT at Arlington Robert Magnusson; Theresa Maldonado Match: $100,000 Raytheon Systems Company Materials Technology Advanced Antennas Using Artificial Magnetodielectrics $393,000 UT at Austin Rodger Walser Match: $100,000 Grant Associates $70,000 Bell Helicopter Textron $70,000 The Boeing Company $70,000 Northrop-Grumman $70,000 General Electric $70,000 Raytheon/TI Systems $70,000 Lockheed Martin Corp. $70,000 Sierra Nevada Corp. Scale-Up of Ceramic Composite Components for Advanced Mining and Aerospace Applications $390,000 University of Houston Ken White; L. Wheeler Match: $350,000 Valvtechnologies, Inc. $80,000 Lockheed Martin Vought Systems Medical Biotechnology Hyperspectral Microscopic Imaging $285,500 UT Southwestern Medical Center at Dallas Match: $1,100,000 Immunicon Corporation Roger Schultz; Harold R. Garner Microelectronics Packaging-Compatible Chip-to-Chip Optoelectric Interconnects for Board-Level System Bus $298,000 UT at Austin Ray Chen; Jack Lipovski Match: $400,000 Radiant Research, Inc. $200,000 LightPath $180,000 3M Corporation $150,000 New Century Consulting $150,000 Texas Instruments, Inc. $100,000 Honeywell $100,000 SEMATECH $50,000 AMP Incorporated $42,500 Dell Computer Company Early Failure Detection for Reliability Evaluation of On-Chip Interconnects $220,000 UT at Austin Paul Ho; Ennis Ogawa Match: $654,000 Motorola $430,000 SEMATECH $72,000 Texas Instruments, Inc. $20,000 Bell Labs/Lucent Technologies Development of 2-D Dopant Profiling Tools for Sub-100 nm Devices $128,500 UT at Austin Chih-Kang Shih Match: $312,000 Motorola $75,000 Advanced Micro Devices $46,560 SEMATECH Nonvolatile Memory Cell Consisting of One Ferroelectric Gate Transistor $100,000 Rice University Thomas Rabson; Marc Robert Match: $100,000 Motorola, Inc. C-20 Telecommunications Implementation of W-CDMA Networks: Advanced Mobile and Basestation Receiver Prototyping $211,148 Rice University Joseph Cavallaro; Don H. Johnson Match: $160,000 Texas Instruments, Inc. $120,000 NOKIA Corporation Development of Integrated Multimedia Wireless Networks $180,000 Rice University Edward Knightly; Behnaam Aazhang Match: $240,000 NOKIA Corporation $160,000 Texas Instruments, Inc. Electrooptics Technology for Fiber Optic Networks $160,000 Texas Engineering Experiment Station Henry Taylor; Ohannes Eknoyan Match: $207,000 3M Corporation C-21 Appendix D Funding by Institution Number of Projects* Institution Angelo State University Baylor College of Medicine Huston-Tillotson College Lamar University LeTourneau University Prairie View A&M University Rice University Sam Houston State University Southern Methodist University Southwest Texas State University Stephen F. Austin State University Sul Ross State University TAMU System Health Science Center Tarleton State University Texas A&M International University Texas A&M University Texas A&M University-Corpus Christi Texas A&M University-Galveston Texas A&M University-Kingsville Texas Agricultural Experiment Station Texas Christian University Texas Engineering Experiment Station Texas Southern University Texas State Technical College Texas Tech University TTU Health Sciences Center Texas Transportation Institute Texas Woman's University University of Houston University of Houston-Clear Lake University of North Texas UNT Health Science Center at Fort Worth The University of Texas at Arlington The University of Texas at Austin The University of Texas at Brownsville The University of Texas at Dallas The University of Texas at El Paso The University of Texas-Pan American The University of Texas at San Antonio UT Health Science Center at Houston UT Health Science Center at San Antonio UT M. D. Anderson Cancer Center UT Medical Branch at Galveston UT Southwestern Medical Center at Dallas TOTALS Dollars 1 10 1 3 2 1 18 2 7 8 2 1 5 2 1 34 1 2 1 31 3 42 2 1 31 2 1 1 55 4 13 3 15 87 1 13 5 7 2 12 6 15 10 20 55,232 1,783,305 12,000 429,313 313,309 38,450 3,309,412 76,510 860,833 510,389 56,783 74,832 609,986 78,160 53,521 3,650,610 35,501 206,906 138,171 4,020,107 345,761 5,232,221 60,100 39,000 3,316,164 78,975 92,687 58,930 7,718,289 233,180 1,270,568 339,405 1,825,604 12,119,570 63,097 1,516,610 381,069 400,157 109,800 1,357,765 764,092 2,444,850 1,467,847 3,515,020 484 $61,064,091 *Joint proposals are counted multiple times -- once for each institution participating in the proposed project. The number of funded projects is 410. Appendix E Comparison of Awards in 1995, 1997, and 1999 Number of Proposals Funded by Area Advanced Research Program Astronomy Atmospheric Sciences Biological Sciences Chemistry Computer/Information Sciences Earth Sciences Engineering Marine Sciences Materials Science Mathematics Physics Social/Behavioral Sciences Advanced Technology Program Aerospace Agriculture and Aquaculture Biomedicine Biotechnology Computer/Information Engineering Energy Environmental Sciences/Engineering Manufacturing Technology Marine Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications Transportation ATP Development and Transfer Aerospace Agriculture and Aquaculture Biomedicine Biotechnology Computer/Information Engineering Energy Environmental Sciences/Engineering Manufacturing Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications 1995 4 3 47 17 11 9 23 5 11 17 13 15 175 1997 4 4 37 18 13 8 26 7 10 15 14 12 168 1999 49 18 13 9 32 11 15 16 13 176 9 32 31 23 17 21 23 20 4 16 11 6 213 8 24 29 29 15 24 13 16 3 20 12 7 200 8 28 33 20 15 23 24 16 23 9 9 8 216 1 2 3 5 1 2 1 3 4 3 1 5 4 3 4 1 4 3 3 2 1 1 1 2 1 3 2 3 2 1 4 3 TOTALS 26 414 30 398 23 415 Comparison of Awards in 1995, 1997, and 1999 Funding Allocations by Research Area Advanced Research Program Astronomy Atmospheric Sciences Biological Sciences Chemistry Computer/Information Sciences Earth Sciences Engineering Marine Sciences Materials Science Mathematics Physics Social/Behavioral Sciences Advanced Technology Program Aerospace Agriculture and Aquaculture Biomedicine Biotechnology Computer/Information Engineering Energy Environmental Sciences/Engineering Manufacturing Technology Marine Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications Transportation ATP Development and Transfer Aerospace Agriculture and Aquaculture Biomedicine Biotechnology Computer/Information Engineering Energy Environmental Sciences/Engineering Manufacturing Technology Materials Technology Medical Biotechnology Microelectronics Telecommunications E-1 1995 260,328 220,686 6,350,426 2,217,463 1,463,260 886,314 3,322,045 629,630 1,537,912 789,596 1,463,585 1,095,585 20,236,830 1997 273,357 329,652 5,744,110 2,221,727 1,714,714 916,642 3,572,523 702,577 1,428,757 747,549 1,418,142 995,410 20,065,160 6,865,320 2,202,707 1,715,153 922,398 3,903,961 1,602,389 711,161 1,568,438 1,046,924 20,538,451 1,446,906 4,434,080 5,864,135 4,315,188 2,887,698 3,154,822 3,541,183 3,007,546 697,859 3,422,463 1,966,024 1,316,490 36,054,394 1,565,183 3,941,835 5,194,244 4,635,717 2,183,157 3,359,187 3,031,427 2,722,802 565,248 3,495,187 1,872,488 1,292,633 33,859,108 1,372,924 4,348,669 6,295,990 3,138,021 2,390,776 4,172,586 3,098,443 2,995,566 4,005,585 1,636,236 1,360,505 983,591 35,798,892 249,576 338,332 372,680 737,761 235,588 374,762 173,360 646,000 559,541 500,000 50,000 4,237,600 568,727 731,227 313,737 981,625 156,216 821,522 845,447 462,940 443,396 201,336 5,526,173 175,000 194,000 365,000 83,000 750,800 447,600 345,200 783,000 285,500 746,500 551,148 4,726,748 1999 Appendix F TOTALS Fund - Priority 1 Fund - Priority 2 Do Not Fund Revise Budget $60,528,824 $59,450,441 Advanced Research Program - 1999 Rank Proposal Evaluation Form (Fund - Priority 1 Proposals only) 61,064,091 Merit and soundness of the proposal (50%) A. Scientific Base/Importance Possible Reviewer Comments: Research of far-reaching significance and based on quality, adequately referenced, scientific work Research important to development of discipline and based on quality, adequately referenced work Research important to development of discipline but based on more speculative research Research is significant in only a narrow area Research not significant within the boundaries of this competition B. Originality Possible Reviewer Comments: Original idea that looks feasible Established technique applied to new area Idea previously investigated C. Research Plan and Budget Possible Reviewer Comments: Well documented research plan with appropriate budget and time schedule Feasible plan but proposed budget or schedule is 25% over or under what is needed to do the job Feasible plan but proposed budget or schedule is 50% over or under what is needed to do the job Poorly thought out research plan Capability of the investigator(s) (25%) D. Staff Possible Reviewer Comments: Principal investigator(s) capable of conducting outstanding research in the proposed area and qualified support personnel listed Principal investigator(s) with some experience in this area and qualified support personnel listed Principal investigator(s) with qualified support staff needed but not included Principal investigator(s) with thus far little demonstrated potential for research in this area Adequacy of institutional commitment and resources (10%) E. Institutional Priority and Available Laboratory Equipment Possible Reviewer Comments: Clear institutional priority with significant institutional support and needed equipment in place Clear institutional priority with significant institutional support and equipment can reasonably be expected to be in place when needed A departmental priority with modest support and equipment can reasonably be expected to be in place when needed A topic of interest primarily to the investigator(s) and/or proposed facilities inadequate to do the job Effect on the infrastructure of science and engineering (15%) F. Education/Training Possible Reviewer Comments: E-3 Research designed to attract, retain, and enhance the qualifications of the best students and researchers Research involves few students and provides modest training for research or innovation No student involvement in proposed research F-2 Fund - Priority 1 Fund - Priority 2 Do Not Fund Revise Budget Advanced Technology Program - 1999 Proposal Evaluation Form Rank (Fund - Priority 1 Proposals only) Merit and soundness of the proposal (50%) A. Importance/Effect on Science and Technology Base Possible Reviewer Comments: Research of far-reaching significance, important to Texas, based on quality, adequately referenced work Research important and based on quality, adequately referenced work Research important but based on more speculative technology Research is significant in only a narrow area Research not significant within the boundaries of this competition B. Originality Possible Reviewer Comments: Original idea that looks feasible Established technique applied to new area Idea previously investigated C. Research Plan and Budget Possible Reviewer Comments: Well documented research plan with appropriate budget and time schedule Feasible plan but proposed budget or schedule is 25% over or under what is needed to do the job Feasible plan but proposed budget or schedule is 50% over or under what is needed to do the job Poorly thought out research plan D. Leveraged Funds and Technology Transfer Possible Reviewer Comments: An idea with a 70% chance of creating a major marketable product in five years and project funds are substantially leveraged from other sources An idea with a 50% chance of producing a marketable product in ten years and project funds are leveraged Prospects for leveraging of funds and/or meaningful industrial collaboration exists Project includes a meaningful collaboration An idea that is unlikely to yield a commercial product; there is no leveraging of funds and no meaningful collaboration exists Capability of the Investigator(s) (15%) E. Staff Possible Reviewer Comments: Principal investigator(s) capable of conducting outstanding research in the proposed area and qualified support personnel listed Principal investigator(s) with some experience in this area and qualified support personnel listed Principal investigator(s) with qualified support staff needed and not included Principal investigator(s) with thus far little demonstrated potential for research Student Involvement and Research Training Opportunities (15%) F. Education/Training Possible Reviewer Comments: Proposed research designed to increase number and quality of scientists and engineers in Texas Proposed research involves few students and provides modest training for research or innovation No student involvement in proposed research Adequacy of institutional commitment and resources (10%) 7. Institutional Priority and Available Laboratory Equipment Possible Reviewer Comments: Clear institutional priority with significant institutional support and needed equipment in place A departmental priority with modest support and the equipment necessary can reasonably expected to be in place when needed A topic of interest primarily to the investigator(s) and/or proposed facilities inadequate to do the job F-3 Fund - Priority 1 Fund - Priority 2 Do Not Fund Technology Development and Transfer Program- 1999 Revise Budget Proposal Evaluation Form Rank (Fund - Priority 1 Proposals only) Technical Merit and Soundness of the Proposal (45%) A. Potential Impact Possible Reviewer Comments: A new technology with wide application that will create new markets A technology that will be important in a narrow range of applications A technology that is interesting but which will have a relatively narrow range of applications Little or no potential impact B. Technological Importance Possible Reviewer Comments: A technologically sophisticated breakthrough technology Interesting but technologically unsophisticated Minimal technological importance C. Plan, Budget and Schedule Possible Reviewer Comments: Well documented research plan with appropriate budget and time schedule Feasible research plan, but proposed budget or schedule is 25% over or under what is needed to do the job Feasible research plan, but proposed budget or schedule is 50% over or under what is needed to do the job Poorly thought out research plan Personnel and Physical Resources Available to the Project (20%) D. Staff Possible Reviewer Comments: Principal Investigator has proven record in developing and transferring technology Staff has good records as scientists but little experience in technology transfer Staff inadequately prepared to undertake project E. Facilities Possible Reviewer Comments: Excellent facilities to undertake project Appropriate facilities to undertake project Inadequate facilities to undertake project Technology Transfer Plan (35%) F. Intellectual Property Possible Reviewer Comments: Ownership of intellectual property well-defined and protected Legal protection of intellectual property initiated Inadequate protection for intellectual property to allow commercialization G. Industrial Collaborator Possible Reviewer Comments: Strong industrial collaborator willing to commercialize in Texas Industrial collaborator only marginally interested in commercializing in Texas No significant industrial collaboration H. Collaboration Plan F-4 Possible Reviewer Comments: Collaborator intimately involved in project with both personnel and financial support Collaborator moderately involved in project with both personnel and financial support Unrealistic collaboration plan Related reports available: Research Assessment Program, Final Report; July 1998 Advanced Research Program/Advanced Technology Program, Progress Report; November 1998 Evaluation of the Advanced Research and Advanced Technology Programs; January 1999 Advanced Research Program/Advanced Technology Program 1999 Program Announcements, April 1999 Research Expenditures September 1, 1997 - August 31, 1998; April 1999 Related information is also available on the web site of the Texas Higher Education Coordinating Board at: http://www.thecb.state.tx.us or the web site of the Coordinating Board=s Research Office in Finance, Campus Planning and Research Division at: http://www.thecb.state.tx.us/divisions/research/research.htm For information about this program contact: Dr. Linda Domelsmith Texas Higher Education Coordinating Board Division of Finance, Campus Planning and Research P.O. Box 12788 Austin, Texas 78711 (512) 483-6150 Internet: domelsmila@thecb.state.tx.us The Texas Higher Education Coordinating Board does not discriminate on the basis of race, color, national origin, gender, religion, age or disability in employment or the provision of services.