ME300.713 Basic Mechanism of Disease (updated 8/20/13)
Course Director: Kathy Gabrielson kgabriel@jhmi.edu and Ralph Hruban rhruban@jhmi.edu
KG Office: 410-955-4584 Cell: 410-493-5808
This overview human disease course uses an organ system approach: includes lectures that will present basic biology,
anatomy, histology and pathology using human clinical cases.
Students will be expected to have reviewed basic histology before the class begins- There are many website to help
you with this- some listed at the end of the syllabus.
Teaching Assistants:
Paweena Chalugun;
Ana Cordova
Jaeyeun Lee:
Xuan Pham:
Devin Sabin:
Michael Urbanowski:
Jane Welch:
Breann Yanagisawa:
Shu-Han Yu:
Brian Tanaka
pchalug1@jhmi.edu
ana@jhmi.edu
jlee461@jhmi.edu
xpham2@jhmi.edu
devin.sabin@gmail.com
murbano1@jhmi.edu
jwelch17@jhmi.edu
bwoelfe1@jhu.edu
zxcvbnm61304@gmail.com
btanaka@jhsph.edu
Breann Yanagisawa Test 1 and Ana Cordova Test 2 will collect (by email) 2 questions and your answers per
lecture slot and per microscope session per diagnosis game from each student. Only use material from lecture
notes and add the slide number and page number where you found this information for your question. These Qs and
As are due within 48 hours of the class. For example, for the day of August 26, 8 Qs and As will be due to represent
key material you learned that day. It will be due at or before 5 pm on August 28 th. Use the template format Breann
sends you to write questions so all students are using a compatible format. Many of these questions will be
used on the two take home exams.
A teaching assistant will be at the beginning lecture for each day and at each diagnosis game. All of the TAs
previously took this course. TAs will be present at the beginning of each class and diagnosis games on the assigned
days
Week 1
Monday, August 26, 2013 – 8 questions due
Time
8:30 - 12:00
1:00 - 2:00
2:15 - 3:15
3:30 - 4:30
Title
Breakfast and overview of class goals,
Diagnosis game, assign groups, microscope
introduction
Cell death
Inflammation
Tissue Repair Inflammation
Instructor
Location
K. Gabrielson
West Room – Turner
Weinberg 2224 (microscope)
A. DeMarzo
Sarah Beck
Bob Anders
West Room
West Room
West Room
Wednesday, August 28, 2013 – 6 questions due
Paweena
Time
8:30- 10:30
10:45 - 12:15
1:30 - 3:00
Title
Review of Infectious Diseases
Review of Infectious Diseases - histopath
Immune system
Instructor
T.C. Wu
Lisa Mangus
W. Matsui
Location
West Room - Turner
Weinberg 2224 (microscope)
West Room
1
ME300.713 Basic Mechanism of Disease (updated 8/20/13)
Course Director: Kathy Gabrielson kgabriel@jhmi.edu and Ralph Hruban rhruban@jhmi.edu
KG Office: 410-955-4584 Cell: 410-493-5808
Time
9:00 - 10:30
10:45 - 12:00
1:00 - 2:15
2:30 - 4:00
Friday, August 30, 2013 – 8 questions due
Ana
Title
Instructor
Neoplasia
E. Gabrielson
Dx Game 1-TAs Brian and Jaeyeun
E. Gabrielson
Pathology of Genetic Diseases
D. Valle
Pathology of Genetic Diseases
K. Burns
Location
West Room - Turner
West Room
West Room
West Room
Week 2
*** NO CLASS ON MONDAY, SEPTEMBER 2, LABOR DAY HOLIDAY ***
Wednesday, September 4, 2013 – 4 questions due
Jaeyeun
Time
Title
9:00 - 12:00
Microscope Review of week 1
1:30 - 2:30
Molecular Pathology
Instructor
Brian Simons, Ralph
Hruban
J. Eshleman
Location
Weinberg 2224 (microscope)
CRB II 1st Floor, Room 111
Friday, September 6, 2013 – 6 questions due
Xuan
Time
9:00 - 10:30
10:30 - 11:30
2:30 - 3:30
Title
Mammary Gland
CNS Lecture Diseases I
Bone Diseases
Instructor
S. Sukumar
C. Eberhart
E. McCarthy
Location
G 03 – Turner
G 03 – Turner
West Room - Turner
Week 3
Monday, September 9, 2013 – 6 questions due
Devin
Time
Title
9:00 – 10:45
Histology Review
10:50-11:55
1:00 - 2:30
Dx Game 2-TAs (2 cases) Xuan and Devin
Eye Pathology
Instructor
Bak Karim, Tasha
Crawford
Petros Karakousis
J. Doyle, G. Shaw
Location
Weinberg 2224
(2nd floor- in surgical path)
Carnegie 489 & Path Library
G07 - Turner
Wednesday, September 11, 2013 – 6 questions due
Michael
Time
9:00 - 10:00
10:00 - 11:45
Muscle Disease
CNS Lecture II
Title
1:15 - 2:30
Brain cutting
Instructor
K. Wagner
J. Troncoso
J. Troncoso,
O. Pletnikova
Location
CRB I, 3M41
CRB I, 3M41
PCTB – G8 Lab
2
ME300.713 Basic Mechanism of Disease (updated 8/20/13)
Course Director: Kathy Gabrielson kgabriel@jhmi.edu and Ralph Hruban rhruban@jhmi.edu
KG Office: 410-955-4584 Cell: 410-493-5808
Friday, September 13, 2013
No class
Take home Test 1- (for week 1, 2 and 3) multiple choice take home will be emailed Sept 13
Week 4
Monday, September 16, 2013 – 6 questions due
Jane
Time
Title
Instructor
9:30 - 10:30
Histology Review
R. Hruban, C. Eberhart
10:30-11:30
1:00 – 3:00
Dx Game 3-TA’s (2 cases) Michael and Jane
Renal Disease
B. Crane K. Burns
L. Arend
Location
Weinberg 2224
(2nd floor- in surgical path)
Ross 503 & 525
West Room - Turner
Wednesday, September 18, 2013 – 6 questions due
Breann
Time
9:00 - 10:30
11:00 - 12:00
1:30 - 3:00
Title
Heart Diseases
Circulatory Diseases
Endocrine
Instructor
C. Steenbergen
C. Steenbergen
P. Caturegli
Location
G 03 – Turner
G 03 – Turner
G 03 – Turner
Friday, September 20, 2013 – 4 questions due
Shu-Han
Time
9:00 – 11:00
1:30 - 3:00
Title
Lung Diseases
GI Disease I and II
Instructor
R. Damico
R. Anders
Location
CRB II, Rm. 111
CRB II, Rm. 111
Week 5
Monday, September 23, 2013 – 2 questions due
Brian
Time
Title
9:00 - 10:45
Histolpathology Review
10:45-11:45
Keep open – make up day
Instructor
L. Arend, R. Anders, M.
Halushka
Location
Weinberg 2224
(2nd floor- in surgical path)
Wednesday, September 25, 2013 – 4 questions
Time
10:00 - 11:30
Title
Dx Game 4-TA’s (2 cases) Breann Shu-Han
and Ana
Instructor
Haluska, Valle
Location
G 03 – Turner
Friday, September 27, 2013 – 4 questions
3
ME300.713 Basic Mechanism of Disease (updated 8/20/13)
Course Director: Kathy Gabrielson kgabriel@jhmi.edu and Ralph Hruban rhruban@jhmi.edu
KG Office: 410-955-4584 Cell: 410-493-5808
Paweena
Time
10:00 – 12:00
1:00 – 3:00
Title
Male Reproductive Pathology
Female Reproductive Pathology
Instructor
G. Netto
I. Shih
Location
G03 – Turner
G03 – Turner
Take home Test 2- (for week 4 and 5) multiple choice take home will be emailed Sept 27,
due October 1
Week 6
Monday, September 30, 2013 Write one question for each dx game and ppt – submit by sept 30 by 11pm
Time
9:00 – 12:00
1:00 – 4:30
Title
Final Diagnosis game
8 groups all TAs to help- arrive at 10am
7 minute-PPT organ system presentations on
any organ system or disease Xuan
Instructor
K. Gabrielson
K. Gabrielson
Location
West Room & Miles Room Turner
West Room
Wednesday, October 2, 2013
Time
9:00 - 12:00
Title
Closed book Final - In class 5% of grade
Instructor
K. Gabrielson
Location
Ross 503 & 525
Suggested reading Text Book- Robbins and Cotran
Pathologic Basis of Disease
8th edition
Chapter 1-8
Book available on line from Welch
Grading Summary:
 2 take-home exams using notes and open book. Each exam is 25% of final grade.
Exams consist of multiple choice questions that cover 2-3 weeks of class. Exams are distributed by email
approximately one week prior to due date. Expect histopathology and gross pathology knowledge testing.
 Review questions and answers- 20% of final grade
Directions: Review questions and answers are designed to help you review material. Write 2 review questions with
answers from the lecture (discussion or notes) and 2 review questions from each microscopic session and 2 review
questions from each diagnosis game. Email these to Bree (test 1) and Ana (test 2) by 48 hours after lecture. Some of
these questions may be picked for the take home exams. ONLY use the template we send you. It is on the website
too. Include as much histopathology and gross pathology knowledge testing questions. ONLY use good quality
pictures.
Website
http://www.hopkinsmedicine.org/mcp/Education/courses.html
Above link has one more step so should be easier
You may have to do a control click to follow the link from the email
Look down the list of class to find my class
2013 is current
You can also look at last year’s notes if you want to look ahead
4
ME300.713 Basic Mechanism of Disease (updated 8/20/13)
Course Director: Kathy Gabrielson kgabriel@jhmi.edu and Ralph Hruban rhruban@jhmi.edu
KG Office: 410-955-4584 Cell: 410-493-5808
 Diagnosis games and ppt- 25% of grade. This exercise is a team learning exercise and a review of the entire
course. There will be multiple sessions. Groups are randomly assigned and consist of 3 or 4 student teams who work
together to diagnose and answer questions about each clinical case. Some of these cases are provided by pathology
residents and faculty. Each student team will also submit one case that could be mentored by a faculty member or
could be based on textbook cases. Cases presentation may consist of the following information: clinical signs and test
results, gross pathology, histopathology and clinical pathology. The game consists of clinical cases in a ppt form
printed in color each in its own notebook. Notebooks are rotated between the teams for 10-15 minutes/case. Each
team answers a series of questions about the case on an answer sheet that is turned in for grading during the exam.
These answers are scored by the faculty and TAs. The team that come in first, second and third place will be given
extra credit points towards any exam. The correct answers are reviewed for the class by the submitter in the second
half of the exercise. These exercises could also be used for potential test questions for the exams.
 The alternative to the ppt above is the educational art project. Read Xuan’s ppt for details (on the website)
 Final exam 5% of final grade. This will be an in class- closed notebook exam. The questions will come from the
lecturers. The format is multiple choice questions. Expect images or cartoons from your notes to be used to test you
on each lecture.
Resources
2013 lecture notes on…
http://www.hopkinsmedicine.org/mcp/
Education
MCP courses
ME300.713 Basic Mechanism of Disease
Some Histology and Pathology websites:
http://basichistology.blogspot.com/2010/01/visual-online-histology-atlas.html
http://www.lab.anhb.uwa.edu.au/mb140 (human histo)
http://www.deltagen.com/target/histolog ... Atlas.html (mouse histo)
http://www.cldavis.org/cgi-bin/download.cgi?pid=799 (mouse necropsy)
5