7ème PCRD : recherches de partenaires - thématique santé – call 2 Project title : Rapid Prion Sensor Partner Search ID: 10 Acronym: RPS Project Type: Small or medium-scale focused research collaborative project Status: Planned for submission Keywords: prion, BSE, TSE, mad cow, scrapie, rapid, detection, diagnostics, food, feed, safety, blood, brain, sensor, biosensor Project Description: Biosensor Systems Design (BSD) has developed a proprietary novel biosensor technology, that can rapidly (<150 seconds) and inexpensively detect specific targets, such as diseasecausing microorganisms and poisons. BSD's technology overcomes the problems associated with traditional biosensors. The biosensor is not dependent on any specific chemistries, optical effects, or electrical properties associated with the binding agents or targets. The technology is suitable for all binding agents ranging from enzymes to antibodies to antigens, synthetic binding agents, receptors and nucleic acids. Call Topics •HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and technologies for high-throughput research Project Details Call references: Call 2nd Main Research Areas: 1. BIOTECHNOLOGY, GENERIC TOOLS AND MEDICAL TECHNOLOGIES FOR HUMAN HEALTH 1.1. HIGH-THROUGHPUT RESEARCH Profile of SME sought Role: technology development, dissemination Country / region: All Europe Start of Partnership: mid-term Expertise required: Target partners will have expertise in (some of) the following areas: food/feed pathogens, animal and human diagnostics, bacteriology, virology, strong knowledge of prion and mutated prion related disease, general food and veterinary science/health, product development and ramp-up, finger on market needs and distribution capabilities. Contact information Mr. Joshua Hexter Biosensor Systems Design, Ltd. P.O.Box 37223 91371 Jerusalem (Israel) Email: jhexter@gmail.com phone: 972-2-6242473 - fax: 972-2-6242797 website: www.biosd.com ----------------------------------------------------------------------------Project title : Understanding the brain’s building blocks Partner Search ID: 59 Acronym: NeuResearch Project Type: Small or medium-scale focused research collaborative project Status: Planned for submission Keywords: functional transformation information complex neuron large scale screening mapping complex neuronal networks Project Description: Only a thorough understanding of the brain’s building blocks will allow building valid models of higher brain functions. The proposed project touches one of the basic yet still unresolved questions in neuroscience. How do neurons process information? What is the neuronal code at the cellular level? Call Topics HEALTH-2007-2.2.1-10: Childhood and adolescent mental disorders. HEALTH-2007-2.2.1-7: Restorative approaches for therapy of neurodegenerative diseases. HEALTH-2007-2.2.1-8: From mood disorders to experimental models. HEALTH-2007-2.2.1-9: Neuronal mechanisms of vision and related diseases. Project Details Call references: Call 2nd Main Research Areas: ii) COMBATING MAJOR DISEASES a) APPLICATIONS-ORIENTATED GENOMIC APPROACHES TO MEDICAL KNOWLEDGE AND TECHNOLOGIES • Studying the brain and combating diseases of the nervous system Profile of SME sought Role: research Country / region: Enlarged Europe & ACC Start of Partnership: mid-term Expertise required: Experimentalists: Cellular neurophysiologists, neuro-biophysicists; Theoreticians: experts in minimization algorithms, experts in artificial neural networks; Industrialists: interested in complex neural networks Contact information Mr. Yoram Lev-Yehudi Beacon Tech Ltd. - dept: International Projects P.O.B. 53040 61530 Tel-Aviv (Israel) Email: info@beacontech.eu phone: +972-52-5216600 - fax: +972-50-8961228 website: http://www.beacontech.eu ----------------------------------------------------------------------------Project title : High throughput protein structure determination Partner Search ID: 76 Acronym: protein-structure-prediction Project Type: Small or medium-scale focused research collaborative project Status: Planned for submission Keywords: Protein structure prediction, nmr, x-ray, high-throughput Project Description: The project is aimed to develop approaches for high-throughput determination of protein structure involving experimentally and bioinformatics approaches. BioLog has a unique, highly flexible computational platform technology which can be used to design and implement different algorithmic solutions which are adapted to different type of protein families. Call Topics • HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and technologies for high-throughput research Project Details Call references: Call 2nd Main Research Areas: 1. BIOTECHNOLOGY, GENERIC TOOLS AND MEDICAL TECHNOLOGIES FOR HUMAN HEALTH 1.1. HIGH-THROUGHPUT RESEARCH Profile of SME sought Role: technology development, research Country / region: Any Start of Partnership: start-up phase Expertise required: Expression of proteins Experimental determination of protein structure (X-ray, Nmr) Contact information Dr. Doron Chema BioLog Technologies Hagavish 4A, P.O. Box 8027 42101 Netaniya (Israel) Email: doron@biolog-tech.com phone: +972-52-222977 - fax: +972-9-8851090 website: www.biolog-tech.com ----------------------------------------------------------------------------Project title : Development of high throughput genomics microfluid platform Partner Search ID: 269 Acronym: HTPDNA Project Type: Research for the benefit of SMEs Status: Planned for submission Keywords: HTP, High-throughput, DNA, gene, expression, deletion, methylation, microRNA, Project Description: Development of a highthroughput and inexpensive platform for gene expression, methylation profiling, microRNA profiling and deletion profiling Call Topics • HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and technologies for high-throughput research Project Details Call references: Call 2nd Main Research Areas: Integration of the best technologies into a new second inexpensive generation genomics platform Budget: 3,000,000.00€ Budget reserved for SMEs: 1,600,000.00€ Profile of SME sought Role: technology development, research, demonstration Country / region: any except Denmark Start of Partnership: start-up phase Expertise required: 1) Optimization of enzyme reactions 2) Development of detection platform (microfluid chip) 3) Development of software 4) Test of chip for the following applications: • expression profiling, • methylation profiling, • micro deletion profiling, • miRNA profiling, 5) Comparing results to state-of-the-art within array and SAGE technologies Contact information Mrs Gitte Pedersen Genomic Expression Postbox 636 DK-2200 Copenhagen (Denmark) Email: glp@genomicexpression.com phone: +45 36960526 - fax: website: http://www.genomicexpression.com ----------------------------------------------------------------------------- Project title: Early processes in the pathogenesis of chronic inflammatory diseases Partner Search ID: 290 Project Type: Large-scale integrating collaborative project Status: Planned for submission Keywords: chronic inflammation, allergy, asthma, autoimmunity Project Description: Chronic immune-mediated diseases constitute a group of non-lethal disorders that have high impact on life quality. Allergic and autoimmune diseases manifested as chronic inflammation are progressive and can lead to end organ damage. It is, therefore, important to elucidate the mechanisms early in disease pathogenesis of chronic inflammatory conditions before irreversible tissue and organ destruction ensues. Our aims have been to investigate the factors governing the initiation and perpetuation of allergic asthma. Afflicted individuals have intermittent and recurrent or chronic-unremitting exacerbations of asthma associated with allergen exposure. These exacerbations progressively destroy the respiratory tract, leaving individuals in their later years chronically disabled. We have established mouse models of allergic asthma in which the focus is on acute-remission-exacerbation phases of disease. We discovered that mice recovered from an initial acute episode of allergic asthma harbor memory CD4+ Th2 lymphocytes within lung infiltrates for their lifetime. These pathogenic cells respond rapidly to allergen exposure and induce disease exacerbation. We hypothesize that lung Th2 memory lymphocytes play a central role in the initiation and perpetuation of exacerbations of allergic asthma and propose to further explore this central hypothesis and build upon our results thus far on the involvement of memory Th2 cells in the lung during remission, allergen-induced exacerbation, during resolution of active inflammation, and unrelenting chronic inflammation. Our goals for this project are to identify and validate molecular networks that define early disease pathogenesis before persistent, chronic inflammation causes irreversible tissue damage and reduced life quality as well as the development of novel and specific antiinflammatory treatments for allergic asthma. Allergic asthma constitutes just one of many chronic inflammatory disorders that are connected to one another by overzealous immune reactions to harmless antigens. We would like to include partners in this project who study chronic immune-mediated inflammatory diseases with the intention of discovering basic mechanisms underlying and linking dysfunctional chronic immune-inflammatory responses in a variety of diseases. Call Topics • HEALTH-2007-2.4.5-12: Early processes in the pathogenesis of chronic inflammatory diseases. Project Details Call references: Call 2nd Main Research Areas: 2.4.5. Other chronic diseases The focus will be on non-lethal diseases with a high impact on the quality of life at old age such as functional and sensory impairment and other chronic diseases (e.g. arthritis, rheumatic and musculo-skeletal diseases and respiratory diseases including those induced by allergies). Expected impact: Collaborative research in this area will develop improved diagnostics and/or intervention strategies with the expected impact of delaying the onset of chronic diseases and improving quality of life. Profile of SME sought Role: technology development, research, dissemination Country / region: member and associated states Start of Partnership: start-up phase Expertise required: We are looking for immunologists, cell biologists, molecular biologists, bioinformaticians, and scientists who use of animal models amenable to genetic testing and manipulation and who are involved with studies in chronic inflammation, allergy, and autoimmunity. Contact information Dr. Michelle Epstein Medical University of Vienna - dept: Department of Dermatology Lazarettgasse 19 A1090 Vienna (Austria) Email: Michelle.Epstein@meduniwien.ac.at phone: +43 1 40160 63012 - fax: +43 1 40160 963012 website: http://www.meduniwien.ac.at/immundermatologie/?main=fors⊂=52〈=en