7ème PCRD : recherches de partenaires - thématique santé – call 2
Project title : Rapid Prion Sensor
Partner Search ID: 10
Acronym: RPS
Project Type:
Small or medium-scale focused research collaborative project
Status: Planned for submission
Keywords: prion, BSE, TSE, mad cow, scrapie, rapid, detection, diagnostics, food, feed,
safety, blood, brain, sensor, biosensor
Project Description:
Biosensor Systems Design (BSD) has developed a proprietary novel biosensor technology,
that can rapidly (<150 seconds) and inexpensively detect specific targets, such as diseasecausing microorganisms and poisons. BSD's technology overcomes the problems associated
with traditional biosensors. The biosensor is not dependent on any specific chemistries,
optical effects, or electrical properties associated with the binding agents or targets. The
technology is suitable for all binding agents ranging from enzymes to antibodies to antigens,
synthetic binding agents, receptors and nucleic acids.
Call Topics
•HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and
technologies for high-throughput research
Project Details
Call references: Call 2nd
Main Research Areas:
1. BIOTECHNOLOGY, GENERIC TOOLS AND MEDICAL TECHNOLOGIES FOR HUMAN
HEALTH
1.1. HIGH-THROUGHPUT RESEARCH
Profile of SME sought
Role: technology development, dissemination
Country / region: All Europe
Start of Partnership: mid-term
Expertise required:
Target partners will have expertise in (some of) the following areas: food/feed pathogens,
animal and human diagnostics, bacteriology, virology, strong knowledge of prion and
mutated prion related disease, general food and veterinary science/health, product
development and ramp-up, finger on market needs and distribution capabilities.
Contact information
Mr. Joshua Hexter
Biosensor Systems Design, Ltd.
P.O.Box 37223
91371 Jerusalem (Israel)
Email: jhexter@gmail.com
phone: 972-2-6242473 - fax: 972-2-6242797
website: www.biosd.com
----------------------------------------------------------------------------Project title : Understanding the brain’s building blocks
Partner Search ID: 59
Acronym: NeuResearch
Project Type:
Small or medium-scale focused research collaborative project
Status: Planned for submission
Keywords: functional transformation information complex neuron large scale screening
mapping complex neuronal networks
Project Description:
Only a thorough understanding of the brain’s building blocks will allow building valid
models of higher brain functions. The proposed project touches one of the basic yet still
unresolved questions in neuroscience. How do neurons process information? What is the
neuronal code at the cellular level?
Call Topics
HEALTH-2007-2.2.1-10: Childhood and adolescent mental disorders.
HEALTH-2007-2.2.1-7: Restorative approaches for therapy of neurodegenerative diseases.
HEALTH-2007-2.2.1-8: From mood disorders to experimental models.
HEALTH-2007-2.2.1-9: Neuronal mechanisms of vision and related diseases.
Project Details
Call references: Call 2nd
Main Research Areas:
ii) COMBATING MAJOR DISEASES
a) APPLICATIONS-ORIENTATED GENOMIC APPROACHES TO MEDICAL
KNOWLEDGE AND TECHNOLOGIES
• Studying the brain and combating diseases of the nervous system
Profile of SME sought
Role: research
Country / region: Enlarged Europe & ACC
Start of Partnership: mid-term
Expertise required:
Experimentalists: Cellular neurophysiologists, neuro-biophysicists; Theoreticians: experts in
minimization algorithms, experts in artificial neural networks;
Industrialists: interested in complex neural networks
Contact information
Mr. Yoram Lev-Yehudi
Beacon Tech Ltd. - dept: International Projects
P.O.B. 53040
61530 Tel-Aviv (Israel)
Email: info@beacontech.eu
phone: +972-52-5216600 - fax: +972-50-8961228
website: http://www.beacontech.eu
----------------------------------------------------------------------------Project title : High throughput protein structure determination
Partner Search ID: 76
Acronym: protein-structure-prediction
Project Type:
Small or medium-scale focused research collaborative project
Status: Planned for submission
Keywords: Protein structure prediction, nmr, x-ray, high-throughput
Project Description:
The project is aimed to develop approaches for high-throughput determination of protein
structure involving experimentally and bioinformatics approaches. BioLog has a unique,
highly flexible computational platform technology which can be used to design and implement
different algorithmic solutions which are adapted to different type of protein families.
Call Topics
• HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and
technologies for high-throughput research
Project Details
Call references: Call 2nd
Main Research Areas:
1. BIOTECHNOLOGY, GENERIC TOOLS AND MEDICAL TECHNOLOGIES FOR HUMAN
HEALTH
1.1. HIGH-THROUGHPUT RESEARCH
Profile of SME sought
Role: technology development, research
Country / region: Any
Start of Partnership: start-up phase
Expertise required:
Expression of proteins
Experimental determination of protein structure (X-ray, Nmr)
Contact information
Dr. Doron Chema
BioLog Technologies
Hagavish 4A, P.O. Box 8027
42101 Netaniya (Israel)
Email: doron@biolog-tech.com
phone: +972-52-222977 - fax: +972-9-8851090
website: www.biolog-tech.com
----------------------------------------------------------------------------Project title : Development of high throughput genomics microfluid platform
Partner Search ID: 269
Acronym: HTPDNA
Project Type:
Research for the benefit of SMEs
Status: Planned for submission
Keywords: HTP, High-throughput, DNA, gene, expression, deletion, methylation, microRNA,
Project Description:
Development of a highthroughput and inexpensive platform for gene expression, methylation
profiling, microRNA profiling and deletion profiling
Call Topics
• HEALTH-2007-1.1-4: SME-driven collaborative research projects for developing tools and
technologies for high-throughput research
Project Details
Call references: Call 2nd
Main Research Areas:
Integration of the best technologies into a new second inexpensive generation genomics
platform
Budget: 3,000,000.00€
Budget reserved for SMEs: 1,600,000.00€
Profile of SME sought
Role: technology development, research, demonstration
Country / region: any except Denmark
Start of Partnership: start-up phase
Expertise required:
1) Optimization of enzyme reactions
2) Development of detection platform (microfluid chip)
3) Development of software
4) Test of chip for the following applications:
• expression profiling,
• methylation profiling,
• micro deletion profiling,
• miRNA profiling,
5) Comparing results to state-of-the-art within array and SAGE technologies
Contact information
Mrs Gitte Pedersen
Genomic Expression
Postbox 636
DK-2200 Copenhagen (Denmark)
Email: glp@genomicexpression.com
phone: +45 36960526 - fax:
website: http://www.genomicexpression.com
-----------------------------------------------------------------------------
Project title: Early processes in the pathogenesis of chronic inflammatory diseases
Partner Search ID: 290
Project Type:
Large-scale integrating collaborative project
Status: Planned for submission
Keywords: chronic inflammation, allergy, asthma, autoimmunity
Project Description:
Chronic immune-mediated diseases constitute a group of non-lethal disorders that have high
impact on life quality. Allergic and autoimmune diseases manifested as chronic inflammation
are progressive and can lead to end organ damage. It is, therefore, important to elucidate the
mechanisms early in disease pathogenesis of chronic inflammatory conditions before
irreversible tissue and organ destruction ensues.
Our aims have been to investigate the factors governing the initiation and perpetuation of
allergic asthma. Afflicted individuals have intermittent and recurrent or chronic-unremitting
exacerbations of asthma associated with allergen exposure. These exacerbations
progressively destroy the respiratory tract, leaving individuals in their later years chronically
disabled. We have established mouse models of allergic asthma in which the focus is on
acute-remission-exacerbation phases of disease. We discovered that mice recovered from an
initial acute episode of allergic asthma harbor memory CD4+ Th2 lymphocytes within lung
infiltrates for their lifetime. These pathogenic cells respond rapidly to allergen exposure and
induce disease exacerbation. We hypothesize that lung Th2 memory lymphocytes play a
central role in the initiation and perpetuation of exacerbations of allergic asthma and
propose to further explore this central hypothesis and build upon our results thus far on the
involvement of memory Th2 cells in the lung during remission, allergen-induced
exacerbation, during resolution of active inflammation, and unrelenting chronic
inflammation. Our goals for this project are to identify and validate molecular networks that
define early disease pathogenesis before persistent, chronic inflammation causes irreversible
tissue damage and reduced life quality as well as the development of novel and specific antiinflammatory treatments for allergic asthma.
Allergic asthma constitutes just one of many chronic inflammatory disorders that are
connected to one another by overzealous immune reactions to harmless antigens. We would
like to include partners in this project who study chronic immune-mediated inflammatory
diseases with the intention of discovering basic mechanisms underlying and linking
dysfunctional chronic immune-inflammatory responses in a variety of diseases.
Call Topics
• HEALTH-2007-2.4.5-12: Early processes in the pathogenesis of chronic inflammatory
diseases.
Project Details
Call references: Call 2nd
Main Research Areas:
2.4.5. Other chronic diseases
The focus will be on non-lethal diseases with a high impact on the quality of life at old age
such as functional and sensory impairment and other chronic diseases (e.g. arthritis,
rheumatic and musculo-skeletal diseases and respiratory diseases including those induced by
allergies). Expected impact: Collaborative research in this area will develop improved
diagnostics and/or intervention strategies with the expected impact of delaying the onset of
chronic diseases and improving quality of life.
Profile of SME sought
Role: technology development, research, dissemination
Country / region: member and associated states
Start of Partnership: start-up phase
Expertise required:
We are looking for immunologists, cell biologists, molecular biologists, bioinformaticians,
and scientists who use of animal models amenable to genetic testing and manipulation and
who are involved with studies in chronic inflammation, allergy, and autoimmunity.
Contact information
Dr. Michelle Epstein
Medical University of Vienna - dept: Department of Dermatology
Lazarettgasse 19
A1090 Vienna (Austria)
Email: Michelle.Epstein@meduniwien.ac.at
phone: +43 1 40160 63012 - fax: +43 1 40160 963012
website: http://www.meduniwien.ac.at/immundermatologie/?main=fors⊂=52⟨=en