Choose the reagent for ascorbic acid identification:
A. Silver nitrate solution, nitrate acid
B. Dragendorff’s reagent
C. Barium chloride solution
D. 2,4-dinitrochlorbenzene
E. Hydroxylamine hydrochloride
ANSWER: A
Calcium ion in the calcium pangamate can be detected with following reagent:
A. Silver nitrate
B. Ammonium oxalate
C. Hydrochloric acid
D. Hydrogen peroxide
E. Potassium dichromate
ANSWER: B
Assay of calcium pantothenate is conducted by the following method:
A. Argentometry
B. Iodometry
C. Permanganatometry
D. Complexonometry
E. Alkalimetry
ANSWER: D
What compound does belong to vitamins of the alicyclic row?
A. Thiamine bromide
B. Retinol acetate
C. Vikasol
D. Ascorbic acid
E. Nicotinic acid
ANSWER: B
What reagents can be used for ergocalciferol identification?
A. 2,4-dinitrochlorobenzene, potassium hydroxide alcohol solution
B. Sodium nitrite, β-naphthalene alkaline solution
C. Chloral hydrate, chloroform
D. Acetylchloride, antimony (ІІІ) chloride, chloroform
E. Cerium sulfate, diphenylamine
ANSWER: D
Retinol acetate by the chemical method can be obtained from:
A. Ergosterine
B. Fructose
C. L-streptose
D. Citral
E. Maltose
ANSWER: D
Ergocalciferol is used in the medical practice for the treatment of:
A. Blood diseases
B. Goiter
C. Cataract
D. Atherosclerosis
E. Rachitis
ANSWER: E
Assay of ascorbic acid according to the SPhU requirements is conducted by the
following method:
A. Complexonometry
B. Acidimetry in non-aqueous environment
C. Alkalimetry in aqueous environment
D. Iodatomerty
E. Iodomerty
ANSWER: E
Ascorbic acid in industry is obtained from:
A. Furfural
B. Fructose
C. L-streptose
D. D-glucose
E. Maltose
ANSWER: D
Gluconic acid residue in the calcium pangamate molecule is detected by the
following solution:
A. Silver nitrate
B. 2,6-dichlorophenolindophenol
C. Ammonium oxalate
D. Iron (ІІІ) chloride
E. Sodium hydroxide
ANSWER: D
Calcium pangamate belongs to the vitamins of:
A. Alicyclic row
B. Aromatic row
C. Aliphatic row
D. Heterocyclic row
E. Polyene row
ANSWER: C
Routine is present in the following tablets content:
A. Papazol
B. No-spa
C. Ascoroutine
D. Reoperin
E. Citramone
ANSWER: C
Nicotinic acid belongs to the vitamins group of:
A. Piperidine
B. Pyrimidine
C. Pyridine
D. Pyrazolone
E. Pyrazol
ANSWER: C
What smell do you fell during the nicotineamide heating with crystalline
sodium carbonate?
A. Aniline
B. Ammonium
C. Acetoacetic ether
D. Fresh apples
E. Bitter almond
ANSWER: B
At the pyridoxine hydrochloride assay by acidimetry in non-aqueous
environment Hg(CH3CОO)2 is added for:
A. Halogen bonding in low-dissociated compound
B. Enhance hydrolysis of the final product
C. Inhibition of the final product hydrolysis
D. Displacement of the reaction equilibrium to the right
E. Displacement of reaction equilibrium to the left
ANSWER: A
Pyridine cycle in the nicotinic acid is detected with:
A. Potassium permanganate solution
B. 2,6-dichlorophenolindophenol
C. 2,4- dinitrochlorobenzene
D. Iodostarch paper
E. Felling reagent
ANSWER: C
Assay of nicotinamide according to the SPhU requirements is conducted by the
following method:
A. Acidimetry in non-aqueous environment
B. Iodometry
C. Permanganatometry
D. Acidimetry in aqueous environment
E. Alkalimetry in non-aqueous environment
ANSWER: A
Which of the following methods is not used for the thiamine hydrochloride
assay?
A. Gravimetry
B. Alkalimetry
C. Acidimetry in non-aqueous environment
D. Bromatometry
E. Fluorimetry
ANSWER: D
Choose medical form of cocarboxylase?
A. Powder for parenteral insertion
B. Powdering
C. Powder for per oral insertion
D. Tablets
E. Injection solutions
ANSWER: A
Source of obtaining cardiac glycosides are different types of:
A. Belladonna
B. Poppy
C. Digitalis
D. Hemp
E. Ephedrine
ANSWER: C
Quantitative determination of cardiac glycosides according to the procedures
DF X is carried out by the method of:
A. Photocolorimetry
B. Acidimetry
C. Infrared spectroscopy
D. Alkalimetry
E. Biological method
ANSWER: E
Steroid cycle in the molecules of cardiac glycosides is revealed by the reaction
of:
A. Rosenheim
B. Legalov
C. Keller-Kilian
D. Pezets
E. Balet
ANSWER: A
Pentamerous lactone cycle in the molecules of cardiac glycosides is revealed by
the reaction of:
A. Lieberman-Burhardt
B. Raymond
C. Rosenheim
D. Keller-Kilian
E. Pezets
ANSWER: B
2-deoxysaccharides in the molecule of cardiac glycosides is revealed by the
reaction of:
A. Legalov
B. Raymond
C. Pezets
D. Rosenheim
E. Lieberman-Burhardt
ANSWER: C
Quantitative determination of cardiac glycosides is carried out by the method
of:
A. Photocolorimetry
B. Acidimetry
C. UV- spectroscopy
D. Alkalimetry
E. Precipitation titration
ANSWER: C
Pentamerous lactone cycle in the cardiac glycosides molecule is revealed by the
reaction of:
A. Raymond
B. Sakagush
C. Lugol
D. Ovchinnikov
E. Rosenkheim
ANSWER: A
Steroid cycle in the structure of cardiac glycosides is revealed by the reaction
of:
A. Legalov
B. Raymond
C. Balet
D. Lieberman-Burhardt
E. Keller-Kilian
ANSWER: D
The drug ouabain is also known as:
A. Strophanthin-G
B. Strophanthin-K
C. Korglikon
D. Adonisid
E. Kardiovalen
ANSWER: A
What glucose properties determine the reaction with ammonia solution of silver
nitrate:
A. The ability to rotate the polarization plane of polarized light
B. Regenerative
C. Oxidative
D. The ability to polymerization
E. The ability to absorb light in the UV-area spectrum
ANSWER: B
The sodium bromide maintenance in the medicinal form: the 20 % sodium bromide
solution can be defined by physical method...
A. chelatometry
B. refractometry, argentometry
C. nitritometry
D. bromatometry
E. permanganatometry
ANSWER: B
The potassium iodide maintenance in the medicinal form: the 10 % potassium
iodide solution can be defined by physical method...
A. nitritometry
B. refractometry
C. chelatometry
D. electrogravimetry
E. permanganatometry
ANSWER: B
The calcium chloride maintenance in the medicinal form: the 5 % calcium
chloride solution can be defined by physical method...
A. refractometry
B. iodometry
C. nitritometry
D. electrogravimetry
E. polarimetry
ANSWER: A
In infra-red spectroscopy the spectrum region is applied to identification of
substances....
A. 200-400 nanometers
B. Ultra-violet region
C. Visible region
D. 400-800 nanometers
E. "Prints of fingers"
ANSWER: E
Refractometry is based on measurement:
A. Absolute index of refraction
B. Relative index of refraction
C. Optical density
D. Transmission factor
E. Specific rotation
ANSWER: B
The absolute index of refraction is the relation of speed of dissemination of
light in... to speed of dissemination of light in...
A. To the given environment; vacuum
B. Vacuum; air
C. Vacuum; to the given environment
D. Air; to the given environment
E. To the given environment; air
ANSWER: C
Absorption spectra in spectrum IR-region are called:
A. The vibration
B. The rotary
C. The electronic
D. The magnetic
E. The paramagnetic
ANSWER: A
Validation - actions in accordance with the principles of GMP argue that any
method, process, equipment, activity or system actually leads to:
A. To expected results
B. To unpredictable results
C. To positive results
D. To very good results
E. To comprehensible results
ANSWER: A
Validation of analytical methods - is experimental evidence that the technique:
A. Very good and easy
B. Suited for the task
C. It is characterised by necessary metrological characteristics
D. Theoretically scientifically proved
E. Practical and rational
ANSWER: B
Validation an analytical technique or process is:
A. Theoretical justification of methods or processes
B. Verification methodology or process logically
C. The experimental proof of their suitability
D. Scientifically based evidence of their ability to provide acceptable
quality
E. Feasibility study of their suitability
ANSWER: C
Validation characteristic “accuracy” is typical for tests:
A. Only quantitative definition
B. Quantitative definition and quantitative test for the maintenance of
impurity
C. Identifications
D. Identification and quantitative definition
E. Identifications and tests for the limiting maintenance of impurity
ANSWER: B
Validation characteristic “accuracy” means that received results are:
A. Are close to true value
B.
C.
D.
E.
Are close to average arithmetic value
Are close to true or average arithmetic value
Highly selective and very specific
Are close among themselves - not so differ
ANSWER: C
Studying of “accuracy” of an analytical technique spend a method:
A. It is entered – it is found
B. The least square method
C. Fisher
D. Student's method
E. Dispersion and an excess
ANSWER: A
Method it is entered-is found, with use of standard samples of components
defined by a given technique, it is applied to studying validation characteristic:
A. Accuracy
B. Convergence
C. Linearity
D. Application range
E. Accuracy and precision
ANSWER: E
The validation characteristic "accuracy" specifies that received results are:
A. Are close to true value
B. Are close to average arithmetic value
C. Close to true or average arithmetic value
D. Highly selective and very specific
E. Close to each other are slightly different
ANSWER: E
Accuracy and precision are metrological characteristics which are investigated
at test validation:
A. Identifications by chemical methods
B. Identifications by physical and physical and chemical methods
C. Quantitative definition of an active pharmaceutical component and
impurity
D. Limiting tests for the maintenance of impurity
E. Definitions quantitative only biological methods
ANSWER: C
As result of testing of a technique on validation characteristic “linearity”,
provide data:
A. The equation of a straight line with all its factors
B. Factors of the equation of a straight line and correlation factor
C. Correlation factor
D. Tangent of a angle of an inclination of a straight line and all
standard deviations for equation factors
E. All listed
ANSWER: E
At the uncertainty forecast of sample preparation which spend for
spectrophotometric definition, consider uncertainty of everything, except:
A. Chemical utensils
B. Pipettes
C. Weight
D. Spectrophotometer
E. Measured flask
ANSWER: D
At the forecast of uncertainty of final analytical operation which spend at
spectrophotometric definitions, consider uncertainty:
A. Chemical utensils
B. Pipettes
C. Weight
D. Spectrophotometer
E. Measured flask
ANSWER: D
At the uncertainty forecast of sample preparation which spend before
chromatographic definition, consider uncertainty of everything, except:
A. Chemical utensils
B. Pipettes
C. Weight
D. Chromatograph
E. Measured flask
ANSWER: D
At the uncertainty forecast of sample preparation which spend before
chromatographic definition, consider uncertainty of everything, except:
A. Chemical utensils
B. Pipettes
C. Weight
D. Cells
E. Measured flask
ANSWER: D
The normalized coordinates of concentration and the analytical response
(physical size) at validation the techniques of the analysis which are carried out
by various methods are represented in units:
A. Percent
B. mg/ml
C. mmol/l
D. mol/l
E. g/ml
ANSWER: A
The normalized coordinates of concentration and the analytical response
(physical size) at validation the techniques of the analysis which are carried out
by various methods have arisen because it was necessary:
A. To unify a way of expression of concentration
B. To unify a way of measurement (direct or relative)
C. To unify a sort of measured physical sizes
D. To unify the size of measured physical sizes
E. To unify criteria requirements for all methods
ANSWER: E
At studying of the metrological characteristic "linearity", count the correlation
factor which value should be:
A. From-2 to +2
B. From -1 to +1
C. From -3 to +3
D. Less than 1
E. More than 2
ANSWER: B
Depending on the nature of substance interaction with electromagnetic radiation
optical methods of the analysis divide on:
A. chromatographic
B. kinetic
C. emission and absorption
D. conductometric
E. voltammetric
ANSWER: C
Decrease of intensity of light which has passed through a solution is connected:
A. With absorption, dispersion, light reflexion
B. Only with light absorption by investigated substance
C. Only with light dispersion
D. Only with light reflexion
E. Intensity of light does not vary
ANSWER: A
Transmission factor it is:
A. Optical density of solution
B. The relation of intensity of falling light to intensity of light which
has passed through a solution
C. The relation of intensity of light which has passed through a
solution to intensity of falling light
D. The relation of intensity of absorbed light to intensity of falling
light
E. The relation of intensity of reflected light to intensity of absorbed
light
ANSWER: C
With what decrease of intensity of light which has passed through a solution is
connected:
A. With absorption, dispersion, light reflexion
B. Only with light absorption by investigated substance
C. Only with light dispersion
D. Only with light reflexion
E. Intensity of light does not vary
ANSWER: A
Absorption optical methods of the analysis are used for the analysis of some
pharmaceutical preparations. What law use in absorption optical methods of the
analysis?
A. Laws of polarised light passage through a optical active substance
solution.
B. The law of light dispersion by environment.
C. Characteristic law for carbon asymmetric atoms.
D. Bouguer-Lambert-Beer law.
E. Law of light refraction.
ANSWER: D
The maintenance of some substance define by spectrophotometric method,
knowing optical density of an investigated solution of substance and a standard
solution of defined substance and concentration of a standard solution. For
calculation of the quantitative maintenance it is necessary to use:
A. Method of additives
B. Method of calibration chart
C. Comparison method
D. Method of molar and specific absorptivity
E. Method of limiting solutions
ANSWER: C
The maintenance of some substance defines by spectrophotometric method,
knowing the equation of linear dependence of optical density from
concentration. For calculation of the quantitative maintenance it is necessary to
use:
A. Method of additives
B. Method of calibration chart
C. Comparison method
D. Method of molar and specific absorptivity
E. Method of limiting solutions
ANSWER: B
To obtaining of monochromatic radiation apply:
A. Optical filters;
B. Photocells;
C. Diffraction grating;
D. System of lenses;
E. Light source.
ANSWER: C
Optical density of an investigated solution measure in relation to one solution
which is called:
A. The control
B. The compensatory
C. The blank
D. The second investigated
E. Control or blank
ANSWER: B
The size of refraction index in refractometric method of the analysis depends:
A. With all factors
B. The substance nature
C. Solution density
D. Lengths of falling light
E. Temperatures and pressure
ANSWER: A
The refractometric method is used in drugstores for:
A. Qualitative definition of cations
B. Quantitative definition of medicinal substances
C. Qualitative definition of anions
D. Definitions of impurity in substances
E. Definition of very small concentration of substances
ANSWER: B
In refractometric method of the analysis the size of refraction index depends
from:
A. Lengths of falling light
B.
C.
D.
E.
The substance nature
Solution density
From all factors
Temperatures and pressure
ANSWER: D
The refractometric method is widely used in drugstores and analytical
laboratories for quantitative definition of medicinal substances, and also their
mixes, as one of the most convenient express methods of the analysis. In basis
refractometric measurements bases dependence between:
A. Electric conductivity of a solution and its concentration.
B. Concentration of substance solution and in its optical density.
C. Concentration of substance solution and its angle rotation.
D. Concentration of substance solution and its refraction index.
E. Quantity of the visible light absorbed by a solution and its
concentration.
ANSWER: D
Relative refraction index define in a method which is called...
A. Polarimetry
B. The thermal analysis
C. Pefractometry
D. Polarography
E. Gravimetry
ANSWER: C
The substances, capable to rotate a polarisation plane of light ray, name optical
active substances. Optical activity of substance can be connected with:
A. Electrolitic dissosiation of investigated substance
B. In temperature a solution
C. Concentration of substance
D. Solvent in which the investigated substance is dissolved
E. Features of crystal lattice of substances, features of molecules
structure
ANSWER: E
The polarisation plane is:
A. The plane is perpendicular to a fluctuation plane of the polarised
light ray
B. The plane of fluctuation of the polarised light ray
C. Planes which are perpendicular to a direction of distribution of
light
D. Parallel to fluctuation plane of the polarised light ray
E. Planes which are parallel to a direction of distribution of light
ANSWER: A
Polarimetric method of the analysis is one of instrumental methods of the
analysis, used for the analysis of some pharmaceutical preparations. Definition
of substances by this method is based on...
A. Measurement of polarisation of electrodes in a cell filled by
investigated solution
B. Potential difference measurement between electrodes poles in the
course of titration
C. Power failure measurement in a cell filled by investigated solution
D. Ionic exchange between an analyzed solution and cationite
E. Measurement of a angle rotation of polarisation plane of the
polarised light which has passed through the optical active
environment
ANSWER: E
What substances can be defined by two methods: polarimerty and
refractometry?
A. Ascorbic acid
B. Sodium benzoate
C. Potassium bromide
D. Sodium thiosulfate
E. Magnesium sulphate
ANSWER: A
At definition of the substances maintenance by polarimetric method define:
A. Molar concentration
B. Titre
C. Volume concentration
D. Mass-volume fraction in solution
E. Mass fraction in solution
ANSWER: D
Physical methods of the medicinal substances analysis it...
A. polarimetric and refractometric
B. nitritometry and mercurometry
C. chelatometry, complexymetry
D. argentometry, mercurometry
E. fluoridometry, acidimetric
ANSWER: A
Physical constants which is the qualitative characteristic of substance in
physical methods of the analysis:
A. Index of refraction, melting temperature
B. Fugitiveness, a smell, colouring
C. Modular condition, smell
D. Solubility
E. Fugitiveness, solubility
ANSWER: A
The medicinal substance maintenance defines in refractometry which help the
measured size of ...
A. Specific rotation
B. Optical density
C. Electromotive power
D. Refraction factor
E. Refraction index
ANSWER: E
The medical product maintenance defines in polarimetry which help constant of
A. Specific rotation
B. Refraction index
C. Electromotive power
D. Optical density
E. Boiling temperature
ANSWER: A
Most essentially such factors, as influence on of solution index refraction...
A. Temperature, pressure, solution density
B. Concentration of a solution, the substance nature, wave length of
light, temperature
C. Solution colouring, рН value
D. Hydrolysis degree, ionic force of a solution;
E. Degree complexing, solution colouring.
ANSWER: B
The calcium chloride quantity in 5 % calcium chloride solution defines by
physical method...
A. alcalimetry
B. refractometry
C. nitritometry
D. cerimetry
E. polarimetry
ANSWER: B
The refractometric method in the drugstore conditions can be applied to the
quantitative analysis:
A. Chemist's preparations, powders, liquid medicinal forms with the
maintenance of components not below 3-5 %
B. Liquid medicinal forms with the maintenance of components not
above 1 %
C. Firm medicinal forms with the maintenance not above 0,1 %
D. Liquid medicinal forms with the maintenance not above 1 %
E. Exclusively soft medicinal forms
ANSWER: A
The magnesium sulphate maintenance in the medicinal form: the 25 %
magnesium sulphate solution can be defined by physical method...
A. refractometry
B. acidimetry
C. bromatometry
D. titanometry
E. polarimetry
ANSWER: A
The sodium bromide maintenance in the medicinal form: the 20 % sodium
bromide solution can be defined by physical method...
A. chelatometry
B. refractometry, argentometry
C. nitritometry
D. bromatometry
E. permanganatometry
ANSWER: B
The potassium iodide maintenance in the medicinal form: the 10 % potassium
iodide solution can be defined by physical method...
A. nitritometry
B. refractometry
C. chelatometry
D. electrogravimetry
E. permanganatometry
ANSWER: B
The calcium chloride maintenance in the medicinal form: the 5 % calcium
chloride solution can be defined by physical method...
A. refractometry
B. iodometry
C. nitritometry
D. electrogravimetry
E. polarimetry
ANSWER: A
The physical method of glucose quantitative definition in the medicinal form: a
25 %glucose solution is...
A. refractometry
B. chelatometry
C. nitritometry
D. electrogravimetry
E. iodometry
ANSWER: A
The aminocaproic acid quantitative definition in 5 % solution spends by
refractometric method, using settlement reception of the quantitative analysis.
In it n0 it is a refraction index of...
A. Ethanol
B. Water
C. Any liquid
D. Any organic solvent
E. Aminocaproic acid
ANSWER: B
The aminocaproic acid quantitative definition in 5 % solution spends by
refractometric method, using settlement reception of the quantitative analysis.
In it n it is a refraction index of...
A. Ethanol
B. Water
C. Any liquid
D. Any organic solvent
E. Investigated aminocaproic acid solution
ANSWER: E
Property on which define the medicinal substance maintenance in polarimetry...
A. Refraction index
B. Optical rotation
C. Absorption of electromagnetic radiation
D. Density
E. Viscosity
ANSWER: B
What physical method of the analysis is based on measurement of optical
properties of investigated system?
A. The chromatographic method
B. The refractometric method
C. The potentiometric method
D. The thermal method
E. The radiometric method
ANSWER: B
What physical method is based on measurement of optical properties of
investigated system?
A. The conductometry
B. The voltammetry
C. The polarography
D. The polarimetry
E. The gas chromatography
ANSWER: D
Energy of infra-red radiation is spent on:
A. Electron transfer to excited vibrational levels
B. Electron transfer between nuclear orbital
C. Electron transfer between molecular orbital
D. Electron transfer from complexing to ligand
E. Electron transfer from ligand to complexing
ANSWER: A
In infra-red spectroscopy active molecules:
A. In the vibration process which changes the electric dipole moment
B. Nonpolar molecules
C. Molecules with odd mass number
D. Molecules with even mass number
E. Molecules with heavy nucleus
ANSWER: A
In infra-red spectroscopy substance molecules are inactive:
A. Methylamine
B. Water
C. Oxygen
D. Dimethylamine
E. Phenylamine
ANSWER: C
In infra-red spectroscopy substance molecules are inactive:
A. CH3NH2;
B. H2O;
C. N2;
D. (CH3)2NH;
E. C6H5NH2.
ANSWER: C
What fluctuations are not shown in an infra-red spectrum?
A. The deformation
B. The symmetric stretching
C. The asymmetric stretching
D. The rocking
E. The nuclear
ANSWER: E
Stretching vibrations in the IR-spectroscopy method are connected with:
A. Change of a valency condition of atom;
B. Change of length of communication;
C. Change of a valency corner;
D. Change of corners between communications;
E. Change of degree of oxidation of an element.
ANSWER: B
Deformation vibrations in IR-spectroscopy method are connected with:
A. Change the valence state of the atom
B. Changes in bond length
C. Change in bond angle
D. Change in the bond angles
E. Change in the degree of oxidation of the element
ANSWER: B
In infra-red spectroscopy use region spectrum:
A. 200 - 400 nanometers
B. 400 - 780 nanometers
C. 4000 - 700 sm-1
D. 700 - 4000 nanometers
E. 200 - 800 nanometers
ANSWER: C
In infra-red spectroscopy the spectrum region is applied to identification of
substances....
A. 200-400 nanometers
B. Ultra-violet region
C. Visible region
D. 400-800 nanometers
E. "Prints of fingers"
ANSWER: E
The spectrum region is applied to identification of substances in infra-red
spectroscopy..., which is called "prints of fingers" and is in limits
A. 1500-700 sm-1
B. 4000-1500 sm-1
C. 4000-2000 sm-1
D. 2000-1500 sm-1
E. 5000-1500 sm-1
ANSWER: A
The region of "prints of fingers" is applied in infra-red spectroscopy to
identification of substances as in this region the absorption connected with
fluctuation is shown:
A. Hydroxy-groups
B. Amino groups
C. Skeleton of the molecule
D. All functional groups
E. Benzene rings
ANSWER: C