MECHANISMS SPECIALTY SECTION
SOCIETY OF TOXICOLOGY
ANNUAL REPORT
2003/2004
I. Introduction
Officers for the year of this report (2003-2004) and for the current year (20042005) are shown below:
President
Vice-President
Vice-President Elect
Secretary/Treasurer
Councilors
2003-2004
Robin Goldstein
Serrine Lau
Daniel Liebler
Gary Rankin
Mike Aleo
John Richburg
Past President
Terry Monks
2004-2005
Serrine Lau
Daniel Liebler
Ken Ramos
Monica Valentovic
John Richburg
Dennis Petersen
Tiffany Bredfeldt
Robin Goldstein
Committees for 2003-2004:
Nominations: Mike Aleo (Chair)
John Richburg
Robin Goldstein
Serrine Lau
Daniel Liebler
Gary Rankin
Annual Meeting Symposium: Serrine Lau for 2004 Annual Meeting
Carl C. Smith Graduate Student Awards
Chair:
John Richburg
Screening Committee:
Dr. George B. Corcoran
Dr. Kamin Johnson
Dr. Mary Kanz
Judging Committee:
Dr. Kerry Blanchard, Jr.
Dr. Andrea Hubbard
Dr. Thomas Sutter
II. Activities
Business Meeting Minutes
The Business Meeting of the Mechanisms Specialty Section was held on
Wednesday, March 24, 2004 in Room 337 at the Baltimore Convention Center,
Baltimore, MD.
The meeting was called to order by Vice-President Dr. Serrine Lau at 6:30 PM.
She welcomed all in attendance and introduced the officers in attendance: Dr.
Terrence Monks, Past President; Dr. Dan Liebler, Vice-President Elect; Dr. Gary
Rankin, Secretary/Treasurer; and Dr. John Richburg, Junior Councilor. She
indicated that current President Dr. Robin Goldstein could not be in attendance
due to business obligations.
Secretary/Treasurer Gary Rankin gave the Treasurer’s Report for the General
Budget and Carl Smith Fund. He indicated that the balance starting July 1, 2003
was $16,831 and that based on projections of income from interest, dues and
meeting income (total estimated to be $8,526) minus projected expenses from
meeting expenses, plaques, non-labor expenses and miscellaneous expense
(total estimated to be $5,880), the Mechanisms income at the end of the fiscal
year should be ~$19,477. He indicated that the Executive Committee was
currently exploring ways to use the growing balance of funds to enhance the
activities of the Mechanisms Specialty Section. He then indicated that based on
figures from the Mechanisms total budget reported by SOT and funds from
members sent to him, the current balance in the Carl Smith Fund is at least
$45,238.
Dr. Lau reviewed the symposia, workshops and Continuing Education courses
sponsored by the Mechanisms Specialty Section at the 2004 Annual Meeting.
She indicated that Mechanisms is sponsoring one CE course, one workshop and
seven symposia (two as primary sponsor indicated below by an *).
Continuing Education Courses
Basic Neurotoxicology
Evelyn C. Tiffany-Castiglioni and William Slikker, Jr.
Sunday, 8:15 AM
Workshops
Nutraceuticals as Double-edged Swords: Weighing Benefits and Risks of Dietary
Chemicals to Human Health
Roger Coulombe and James Pestka
Monday, 1:30 PM
Symposia
Steroid Inactivation: Alternative Mechanisms of Endocrine Toxicity
Gerald LeBlanc and Li You
Monday, 9:30 AM
Gene Expression Influences on Metal Immunomodulation
David Lawrence and Michael Lynes
Monday, 1:30 PM
Mechanisms of Cardiovascular Toxicity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
and Related Halogenated Aromatic Hydrocarbons*
Nigel Walker and Mary Walker
Tuesday, 8:30 AM
New Developments in Oxidative Phospholipid Signaling in Apoptosis and
Phagocytic Regulation of Inflammatory Response*
Valerian Kagan and Dean Jones
Tuesday, 8:30 AM
Arsenic Disruption of Cell Cycle: Mechanisms and Effects on Apoptosis,
Differentiation and Carcinogenesis
Michael McCabe and J. Christopher States
Wednesday, 8:30 AM
Use of Molecular Approaches to Examine Mechanisms of Neurotoxicity
Gary Miller and William Atchison
Wednesday, 1:30 PM
Molecular Profiling and Computer Modeling in Early Detection and Treatment of
Cancer
Craig Marcus and David Eaton
Thursday, 8:30 AM
Vice-President Elect Dan Liebler called for the submission of Continuing
Education Course, Workshop and Symposium proposals by members for the
2005 SOT Annual Meeting in New Orleans, LA. The deadline for submission of
proposals is April 15, 2004, with recommendations from the Mechanisms
Specialty Section due at SOT Headquarters April 30, 2004.
Dr. Lau introduced the new officers for the Mechanisms Specialty Section who
will assume their duties May 1, 2004. These officers are: Vice-President Elect –
Dr. Ken Ramos; Secretary/Treasurer – Dr. Monica Valentovic; Junior Councilor –
Dr. Dennis Petersen; and Student Councilor – Ms. Tiffany Bredfeldt.
Plaques were then presented by Dr. Liebler to outgoing officers: Past President
Dr. Terrence Monks and Secretary/Treasurer Dr. Gary Rankin. Outgoing Senior
Councilor Dr. Michael Aleo was unable to attend the meeting and Dr. Liebler
indicated that he will send Dr. Aleo’s plaque to him.
Junior Councilor John Richburg presented a short history of the Mechanisms
Specialty Section and the Carl Smith Award. He indicated that the history is
available on-line at the SOT website by going to the Mechanisms Specialty
Section page. He also indicated that over the years 258 awards and $18,850
have been presented to winners in the Carl Smith Graduate Student Award
competition. For the 2004 competition, 27 applications were received. Initial
screening by a panel of Screening Judges reduced this number to 12
applications. Following the submission of a full length manuscript, the twelve
applications were reviewed by a panel of Final Judges and the winners selected.
Dr. Richburg acknowledged the judges involved in the screening and final
selection process. He then thanked Taylor & Francis for their generous support
of the Carl Smith Fund ($500 donation) and for presenting the First, Second and
Third Place winners with gift certificates. Ms. Nicole Johnson from Taylor &
Francis was on hand to present the Taylor & Francis Gift Certificates to the
winners. The panels of judges and winners are listed below.
Screening Judges
Dr. George B. Corcoran
Wayne State University
Detroit, MI
Dr. Mary Kanz
UT Medical Branch
Galveston, TX
Dr. Kamin Johnson
CIIT
Research Triangle Park, NC
Final Judges
Dr. Kerry Blanchard, Jr.
Boehringer Ingelheim Pharmaceuticals, Inc.
Ridgefield, CT
Dr. Thomas Sutter
University of Memphis
Memphis, TN
Dr. Andrea Hubbard
University of Connecticut
Storrs, CT
Carl C. Smith Graduate Student Award Winners
First Place
WINNIE JENG and P.G. Wells. Department of Pharmacology, Faculty of
Pharmacy, University of Toronto, Toronto, ON, Canada. “FREE RADICAL
DETERMINANTS
OF
AMPHETAMINE
NEURODEGENERATION:
PROSTAGLANDIN H SYNTHASE (PHS)-CTALYZED FREE RADICAL
FORMATION AND REACTIV EOXYGEN SPECIES (ROS)-MEDIATED
OXIDATIVE DNA DAMAGE IN NEURAL DEGENERATION AND FUNCTIONAL
DEFICITS.”
Second Place
GARY D. MINSAVAGE, G.S. Bedi and T.A. Gasiewicz. Toxicology Training
Program, Dept. Environmental Science, University of Rochester School of
Medicine and Dentistry, Rochester, NY. “PROTEIN KINASE C (PKC)-ELICITED
PHOSPHORYLATION OF THE ARYL HYDROCARBON RECEPTOR (AhR) IS
INHIBITED BY MUTATION OF AhR TYROSINE 9.”
Third Place (tie)
JING DONG, Sampath Ramachanduran, Serrine S. Lau and Terrence Monks.
Depart. Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ. “A ROLE FOR p38 MAPK IN ROS-INDUCED ONCOTIC
CELL DEATH IN RENAL CELLS.”
STEFFAN T. NAWROCKI, Jennifer S. Carew and David McConkey. University of
Texas M. D. Anderson Cancer Center, Houston, TX. “THE PROTEASOME
INHIBITOR, BORTEZOMIB, STIMULATES APOPTOSIS BY INDUCING
ENDOPLASMIC RETICULAR STRESS AND PROTEOTOXICITY.”
Honorable Mention
(Listed Alphabetically)
IRIS A. CAMACHO, Mitzi Nagarkatti and Prakash S. Nagarkatti. Virginia
Commonwealth University, Richmond, VA. “ IN VIVO MOLECULAR
MECHANISMS OF TCDD-INDUCED CELL DEATH IN THE THYMUS:
EVIDENCE FOR AHR-DEPENDENT APOPTOSIS VIA ACTIVATION OF
MITOCHONDRIAL AND DEATH-RECEPTOR PATHWAYS.”
KARI A. COX, A.H. Palmer, S.S. Lau, K.N. Dalby and T.J. Monks. Division of
Pharmacology and Toxicology and Medicinal Chemistry, University of Texas at
Austin and Department of Pharmacology and Toxicology, College of Pharmacy,
University of Arizona, Tucson, AZ. “DNA DAMAGE-INDUCED HISTONE H3
PHOSPHORYLATION DOES NOT INVOLVE SITES NORMALLY ASSOCIATED
WITH MITOTIC CHROMOSOMAL CONDENSATION.”
YINGYING GUO, Helmut Zarbl, Linda L. Breeden, Bradley D. Preston and David
L. Eaton. Department of Environmental and Occupational Health Sciences,
University of Washington, Seattle, WA. “CHARACTERIZATION OF DNA
REPAIR MECHANISMS FOLLOWING AFLATOXIN B1 TREATMENT IN YEAST
EXPRESSING HUMAN CYTOCHROME P450 (CYP) 1A2.”
JERRY E. JOHNSON, JR., K. Choski and W.R. Widger. Department of
Optometry, University of Houston, Houston, TX. “A MODEL OF TOXICANTINDUCED OXYGEN FREE RADICAL PRODUCTION FROM ISOLATED
BOVINE REPIRATORY CHAIN COMPLEX I.”
MIDHUN C. KORRAPATI, E.A Lock and H. M. Mehendale. College of Pharmacy,
University of Louisiana at Monroe, Monroe, LA. “NF-Kb MEDIATED
TRANSACTIVATION
MECHANISMS
OF
G1-TO-S
CELL
CYCLE
PROGRESSION IN AUTOPROTECTION AGAINST S-1,2-DICHLOROVINYL-LCYSTEINE INDUCED ACUTE RENAL FAILURE.”
JENNIFER L. MARLOWE and Alvaro Puga. Department of Environmental
Health, University of Cincinnati, Cincinnati, OH. “TCDD-MEDIATED
ACTIVATION OF THE AROMATIC HYDROCARBON RECEPTOR DISPLACES
p300 FROM E2F-DEPENDENT PROMOTERS.”
VICTORIA E. RICHARDS, B. Chau and C.A. McQueen. Department of
Pharmacology and Toxicology, College of Pharmacy, University of Arizona,
Tucson, AZ. “GENE EXPRESSION PROFILE OF HEPATIC STEATOSIS IN
PPARa DEFICIENT MOUSE LIVER AFTER EXPOSURE TO HYDRAZINE.”
LYNETTE K. ROGERS, Toshiya Tamura, Byran J. Rogers, Thomas N. Hansen,
Stephen E, Welty and Charles V. Smith. Columbus Children’s Research Institute,
Columbus,
OH.
“MOLECULAR MECHANISMS
OF
SUBCELLULAR
LOCALIZATION OF HUMAN GLUTATHIONE REDUCTASE.”
Dr. Lau announced three future meetings. (1) The 2004 Gordon Research
Conference, “Mechanisms of Toxicity” will be held July 25-30, 2004 at Colby
College in Waterville, ME. Chair for the meeting is Dr. Kenneth Ramos and Vice
Chair is Dr. Charlene McQueen. Meeting information can be obtained at
http://www.grc.org. (2) A Joint Specialty Symposium on Renal Toxicology and
Toxicologic Pathology entitled “An Integration of Mechanistic and Morphological
Evaluation” will be hosted by the Society of Toxicology and the European Society
of Toxicologic Pathology September 27 – October 1, 2004 in Lindau/Bodensee,
Germany. The Symposium organizers are Dr. Ulrich Deschi and Prof. Dr. Daniel
Dietrich.
More
information
can
be
obtained
at
http://www.toxicology.org/memberservices/meetings/nephrotoxicity.html. (3) A
Biological Reactive Intermediates meeting, chaired by Dr. Terrence Monks, will
be held in 2006 in Tucson, AZ. Details will be available in the near future.
No other business was brought forth, and the meeting was adjourned at 7:05 PM.
III. Financial Status (07/01/03 – 06/30/04)
The revenue figures are based on estimates. Exact figures are not available from
SOT at this time.
Estimated (E.) Revenue
E. Dues
E. Meeting Registration
Interest as of 03/31/04
$3,360
$4,324
$ 574
E. Total estimated income
$8,258
Expenses
Executive meeting
Reception Ann. Meeting
Plaques
Misc.
$ 278
$4,864
$ 245
$ 136
Total expenses
$5,523
Excess of revenue over expenses
$2,735
Net Assets beginning 07/01/03
$16,831
Estimated Assets as of 06/30/04
$19,566
These numbers are based on dues and meeting revenue estimates provided in
the annual meeting planner document and the interest and expenses provided in
the March 31, 2004 financial statement for the Mechanisms Specialty Section.
The March statement is the current (9/29/04) and most recent posted statement.
Additional deposits in interest should be added to these figures when available
from SOT.
Carl C. Smith Award Fund Balance:
The balance in the Carl Smith Fund is again an estimate. The balance as of
07/01/03 was $44,563. Contributions made through the Secretary/Treasurer
were $675 as of 03/15/04. An additional $500 was contributed by Taylor &
Francis at the Annual Meeting. It is unclear how much was contributed directly to
SOT for the Carl Smith Fund as those figures have not been provided. Awards
totaling $900 were made to students at the annual meeting. Thus, the balance in
the Carl Smith Fund is estimated to be ~ $44,838.
IV. Future Plans
In 2004-2005 the Mechanisms Specialty Section will:
1. Promote excellence by the development of high quality symposia, workshops
and CE courses for the upcoming annual SOT meetings.
2. Work to strengthen the support for the Carl C. Smith graduate student award
from the membership of the Mechanisms Specialty Section and to increase
student submissions for these awards.
3. Encourage more student involvement in the Mechanisms Specialty Section.
4. Work with SOT to improve the timeliness of accounting reporting for the
Mechanisms Specialty Section general account and Carl C. Smith Fund.
5. Work on development of the web page for the Mechanisms Specialty Section.