PHYSO 2A SG-1 Cara Burres-Jones, PCC Unit 1 – Study Guide Intro, Cell & Mitosis, Histology, Integumentary System (+ some biochemistry and genetics) Identify, Define, Describe or Give the Significance of the Following: CHAPTER 1: Anatomy gross histology regional systemic embryology Physiology comparative Pathology Dissection Cadaver Palpation Galen & Vesalius Hooke & Leeuwenhoek First microscopes Schleiden & Schwann Cell theory Scientific Method Fact vs Law vs Theory Evolution Natural Selection Primate adaptations Bipedal vs Quadripedal Hominids Atom Molecule-->Macromolecules Cell Tissue Organ Organ System Organism Emergent property Characteristics of Life: Cellularity Metabolism Catabolism & Anabolism Responsiveness Growth Reproduction Homeostasis “Reference Man” Equilibrium Feedback: Negative & Positive Anatomical terminology&eponyms EXAMPLES OF LATIN SINGULAR to PLURAL: syllabus syllabi humerus humeri cactus cacti radius radii lumen lumina diagnosis diagnoses appendix appendices ulna ulnae tibia fibula plura femur auditorium pericardium medium peritoneum ganglion phalanx calyx tibiae fibulae plurae femora auditoria pericardia media peritonea ganglia phalanges calyces ATLAS A: Anatomical position Supine vs Prone Longitudinal sections Sagittal planes/section -Mid- & Parasagittal Frontal (coronal) plane/section Transverse (cross) plane/section Oblique section Cranial-Caudal Superior-Inferior Ventral-Dorsal Anterior-Posterior Medial-Lateral Superficial-Deep Parietal-Visceral Proximal-Distal Ipsilateral-Contralateral Axial Region: cephalic frontal orbital nasal oral buccal (cheek) lingual (tongue) mental otic (ear region) occipital cervical thoracic pectoral mammary sternal scapular vertebral abdominal the 9 subdivisions* umbilical coxal or iliac pubic 1 lumbar sacral gluteal perineal Appendicular Region: acromial axillary brachial antecubital cubital or olecranal antebrachial manus (or manual region) carpal metacarpal (palmar=anterior metacarpal) phalangeal (or digital) pollex (=thumb, or digit I) inguinal femoral patellar popliteal crural sural peroneal or fibular pes (or pedal region) tarsal calcaneal metatarsal (plantar=ventral metatarsal) phalangeal (or digital) hallux (=great toe) 9 Abdominal Regions* Umbilical Epigastric Hypogastric Lumbar Iliac (or Inguinal) Hypochondriac Body cavities dorsal spinal cranial ventral thoracic mediastinum pericardial pleural diaphragm abdominal pelvic Serous membrane (serosa) pericardia, visceral & parietal plurae, visceral & parietal peritonea, visceral & parietal mesentary PHYSO 2A Organ Systems: •List all 11 •Know basic function •Name at least 3 organs from •ID organs on models CHAPTER 2: (Much of Chapter 2 will be covered on a take home assignment. The following you need to know for your lecture exam:) pH acidic vs basic (alkaline) potential energy vs kinetic energy monomer vs polymer hydrolysis vs dehydration synthesis carbohydrates mono, di, polysaccharides glucose vs glycogen (animals) glucose vs starch vs cellulose (plants) lipids fatty acids saturated vs unsaturated triglycerides phospholipids steroids eicosanoids proteins amino acids 1º, 2º, 3º & 4º structure enzymes nucleic acids nucleotides ATP DNA & RNA CHAPTER 3: Cell & Cell Theory Cytoplasm vs Cytosol Intracellular fluid (ICF) Extracellular fluid (ECF) Cell (plasma) membrane (=plasmalemma) Phospholipids Transmembrane proteins Peripheral proteins Receptors Enzymes Channel proteins Ligand-gated Voltage-gated Mechanically-gated Carriers and Pumps Glycoprotein Identity Marker CAMs Second-messenger systems G-Proteins Microvilli (“brush border”) Cilia Flagella SG-1 Filtration Diffusion Concentration gradient Osmosis Aquaporins Osmole Tonicity Hypotonic Hypertonic Isotonic Carrier-mediated transport Uniport Symport Antiport Facilitated transport Active transport Sodium-potassium pump Secondary active transport Na+-K+ & SGLT Vesicular transport Endocytosis Phagocytosis Pseudopods Pinocytosis Pinocytotic vesicles Exocytosis Transcytosis Nucleus Mutinucleate Uninucleate Nuclear envelope (membrane) Chromatin Nucleoli Endoplasmic reticulum Rough & Smooth Ribosomes Golgi Complex Secretory vesicles Lysosome Peroxixomes Mitochondria Cristae Centrioles Cytoskeleton Microtubules Centrioles & Spindle Cilia & Flagella Intermediate filaments Microfilaments CHAPTER 4: DNA Chromatin Chromosomes Gene Nucleotides Nitrogenous bases Cytosine Thymine Adenine Guanine Uracil 2 Cara Burres-Jones, PCC RNA m-RNA t-RNA r-RNA Protein synthesis (translation) Base triplet Codon Anti-codon Transcription Translation Polyribosomes Replication Mutation Cell Cycle G1, S, G2, M (itosis) Interphase vs Mitosis Replication Mitosis Prophase Metaphase Anaphase Telophase Cytokinesis Heredity Homologous Autosomes vs Sex chromosomes Somatic cells vs Germ cells Diploid vs Haploid Homozygous vs Heterozygous Genotype vs Phenotype Dominant vs Recessive Codominant, Incomplete dominance Sex-linked traits CHAPTER 5: Histology Tissue Organ Epithelial tissue Connective tissue Muscle tissue Nervous tissue Embryonic germ layers Ectoderm Mesoderm Endoderm Simple vs. Stratified Pseudostratified Transitional Apical surface Basal surface Basement membrane basal lamina reticular lamina “Free space” Lumen Avascular Squamous Cuboidal Columnar PHYSO 2A Goblet cell Microvilli Cilia Simple squamous Simple cuboidal Simple columnar Pseudostratified ciliated columnar Stratified squamous Keratinized Non-keratinized Stratified cuboidal Stratified columnar Transitional Mesenchyme Connective Tissue Proper Loose C.T. Areolar (“loose irregular”) Adipose Reticular Dense C.T. Dense irregular Dense regular Elastic Other Connective Tissues Cartilage Bone Blood Matrix ground substance protein fibers collagen elastin reticular collagen fibers Glucosaminoglycans (GAGs) Chondroitin sulfate Hyaluronic acid Heparin Proteoglycans Fibroblast Macrophage Mast cell Adipocyte Chondrocyte Osteocyte Lacuna Erythrocyte Leukocyte Platelet Neurons Neuroglial cells Smooth Muscle Skeletal Muscle Cardiac Muscle Tight junction Anchoring junction (desmosome) Gap junction Endocrine gland Exocrine gland Multicellular gland SG-1 Simple vs Compound Tubular Alveolar Tubuloalveolar Merocrine Apocrine Holocrine Unicellular gland Goblet cell Mucus & Mucin vs. Mucous Endothelium Mesothelium Serous membrane Mucous membrane Lamina propria Cutaneous membrane Stem cells Pluripotent vs Unipotent Regeneration Fibrosis Granulation tissue Remodeling Atrophy Hypertrophy Necrosis Infarction Apoptosis CHAPTER 6: Integument Skin Cutaneous membrane Epidermis Dermis Hypodermis (superficial fascia or subcutaneous layer) Exfoliation Dander (dandruff) Stratum corneum Stratum lucidum Stratum granulosum Stratum spinosum Stratum germinativum (basale) Keratinocyte Keratin Melanocyte Melanin, Eumelanin, Pheomelanin Albinism Jaundice Friction ridges (‘finger prints’) Flexion lines Tactile (Merkel) disc Dendritic (Langerhans) cells Dermal papilla (pl.=papillae) Epidermal ridges Papillary layer Reticular layer Meissner’s corpuscle Pacinian corpuscle Root hair plexus (hair receptor) 3 Cara Burres-Jones, PCC Pilus Terminal hair Vellus hair Lanugo Pilosebaceous apparatus -Hair follicle -Hair (w/bulb, root & shaft) -Sebaceous gland Sebum -Arrector pili muscle Hair medulla, cortex & cuticle Alopecia (baldness) (male) Pattern baldness Nail root Nail matrix Nail plate (body & free edge) Nail bed Eponychium = cuticle Hyponychium Lunule (or lunula) Dermatology Sudoriferous (sweat) gland Eccrine sweat gland Apocrine sweat gland Myoepithelial cells Insensible vs Sensible perspiration Ceruminous gland Cerumen Mammary glands Holocrine gland (‘whole cell’) Apocrine gland (orig. ‘apex of cell’, now just name of gland) Merocrine gland (‘liquid’ only) Skin cancer Basal cell carcinoma Squamous cell carcinoma Melanoma Rule of Nines 1st, 2nd & 3rd degree burns Debridement Acid mantle OTHER: Biology & Modern Synthesis: -Evolution -Structure & function of DNA -Evo-devo Modular design Regulatory DNA & Hox genes **Importance Hierarchy** Atlas A & Chapter 5 Chapter 3 & Chapter 6 Chapter 1, Chapter 4 & Chapter 2