Online Appendix for the following JACC article
TITLE: A Prospective, Randomized, Evaluation of a Novel Everolimus-Eluting Coronary Stent:
The PLATINUM (A Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting
Coronary Stent System [PROMUS Element] for the Treatment of up to two De Novo Coronary
Artery Lesions) Trial
AUTHORS: Gregg W. Stone, MD, Paul S. Teirstein, MD, Ian T. Meredith, MBBS, PhD, Bruno
Farah, MD, Christophe L. Dubois, MD, PhD, Robert L. Feldman, MD, Joseph Dens, MD, PhD,
Nobuhisa Hagiwara, MD, Dominic J. Allocco, MD, Keith D. Dawkins, MD, for the PLATINUM
Trial Investigators
Appendix
PLATINUM Trial organization and list of participating investigators:
Steering Committee – G.W. Stone (Principal Investigator), Columbia University Medical
Center/New York-Presbyterian Hospital and the Cardiovascular Research Foundation, New
York, NY; P.S. Teirstein (Co-Principal Investigator), Scripps Clinic, Division of Cardiovascular
Diseases, La Jolla, CA; I.T. Meredith (Co-Principal Investigator), MonashHEART, Southern
Health, Monash Medical Centre, Clayton, Victoria, Australia; K. D. Dawkins, E. Rose, D. J.
Allocco, P. Maurer, Boston Scientific Corporation, Natick, MA.
Data Safety and Monitoring Committee – W.D. Weaver (Chair), Henry Ford Heart and Vascular
Institute, Detroit, MI; S.R. Bailey, University of Texas, San Antonio, TX; D.P. Faxon, Brigham
and Women's Hospital, Boston, MA; D.J. Moliterno, University of Kentucky Medical Center,
Lexington KY; J.G.P. Tijssen, University of Amsterdam, Amsterdam, The Netherlands; A
Greenbaum, Henry Ford Hospital, Detroit, MI.
Data Management, Biostatistical Analysis, Safety Monitoring – Boston Scientific Corporation,
Natick, MA.
Clinical Events Adjudication Committee – D.G. Hurrell (Chair, Minneapolis Cardiology
Associations, Minneapolis, MN); J. Chambers (Metropolitan Cardiology Consultants, P.A.,
Minneapolis, MN); D.D. Laxson (Minnesota Heart Clinic, P.A., Edina, MN); Y.L. Wang
(Cardiovascular/Peripheral Vascular Interventions Minneapolis Heart Institute, Minneapolis,
MN); R.F. Wilson (University of Minnesota Cardiovascular Division, Minneapolis, MN).
Angiographic Core Laboratory – Beth Israel Deaconess Medical Center, Boston, MA; J. J.
Popma (Director).
Pharmacokinetic Core Laboratory – Eurofins Medinet B.V., Breda, The Netherlands; G.A.J.M.
Wouters (Study Director).
Study Sites, Principal Investigators, and Primary Study Coordinators (number of enrolled
patients) – Clinique Pasteur, Toulouse, France, Bruno Farah, Frederic Petit (54); University
Hospital Leuven, Leuven, Belgium, Christophe Dubois, Gina van Oosterwijck (51); Mediquest
Research Group, Inc. at Munroe Regional Medical Center, Ocala, FL, Robert Feldman, Deb
McIntyre (41); Ziekenhuis Oost Limburg, Genk, Belgium, Joseph Dens, Caroline Swijsen (36);
Baptist Medical Center Princeton, Birmingham, AL, Alain Bouchard, Wesley Wade (35); Centre
Hôpital Universitaire Rangueil, Toulouse, France, Didier Carrié, Jacqueline Cahuzac (35);
Kerckhoff Klinik, Bad Nauheim, Germany, Helge Moellmann, Cornelia Kisselbach (35); Golden
Jubilee National Hospital, Clydebank, UK, Keith Oldroyd, Joanne Kelly (33); St. Vincent's
Hospital, Indianapolis, IN, Jack Hall, Marylynn Burkert (32); Baylor Heart and Vascular Hospital,
Dallas, TX, Robert Stoler, Lucy Kang (29); Tokyo Women's Medical University Hospital, Tokyo,
Japan, Nobuhisa Hagiwara, Miyoko Naganuma (29); TexSan Heart Hospital, San Antonio, TX,
Abram Rabinowitz, Susan Meier (28); Mercy St. Vincent Medical Center, Toledo, OH, Ameer
Kabour, Michelle Hickam (27); Ohio State University Medical Center, Columbus, OH, Vincent
Pompili, Luba Mazanec (27); Moses H. Cone Memorial Hospital/LeBauer Cardiovascular
Research Foundation, Greensboro, NC, Thomas Stuckey, Donna Ricks (25); Southampton
University Hospital, Southampton, UK, Nicholas Curzen, Zoe Nicholas (24); St. John's
Hospital/Southern Illinois University Memorial Medical Center, Springfield, IL, Gregory Mishkel,
Jennifer Jones and Robin Swinford (24); P. Stradins University Hospital, Riga, Latvia, Andrejs
Erglis, Alona Grave (23); Shonan Kamakura General Hospital, Kanagawa, Japan, Shigeru
Saito, Izumi Kobayashi (23); Clinique du Millénaire, Montpellier, France, Gilles Levy, Chrystel
Leperchois (22); CHU de Besancon, Besancon, France, François Schiele, Gerald Sergent (21);
Medical Center of the Rockies (Loveland), Loveland, CO, Thomas Downes, Scott Kaczkowski
(21); The Christ Hospital Heart and Vascular Center/The Lindner Center for Research and
Education at The Christ Hospital, Cincinnati, OH, Dean Kereiakes, Ersela McGary (21); Wake
Medical Center, Raleigh, NC, Tift Mann, Sarah Mulkey (21); Alvarado Hospital, San Diego, CA,
Maurice Buchbinder, Heather Nielsen (20); Sakakibara Heart Institute, Japan Research
Promotion Society for Cardiovascular Diseases, Tokyo, Japan, Ryuta Asano, Tomoko Tajima
(20); Sisters of Charity Providence Hospital, Columbia, SC, Michael Foster, Jacqueline SheriodScott (20); SPZOZ Szpital Uniwersytecki w Krakowie, Krakow, Poland, Dariusz Dudek, Elzbieta
Kolny (20); Jackson-Madison County General Hospital, Jackson, TN, Henry Lui, Pam Gibbons
(19); Academisch Ziekenhuis Middelheim, Antwerpen, Belgium, Paul Vermeersch, Nancy Aerts
(17); St. Vincent's Hospital, Fitzroy, Victoria, Australia, Robert Whitbourn, John Gough and
Jenny Wilson (17); Abbott Northwestern Hospital, Minneapolis, MN, Michael Mooney, Holly
MacDonald (16); Florida Hospital, Orlando, FL, Andrew Taussig, Delores Barnes (16); Medical
Center of Central Georgia, Macon, GA, Mark Dorogy, Carrie Knott (16); Oulu University
Hospital, Oulu, Finland, Matti Niemelä, Eija Niemelae (16); Scripps Clinic, La Jolla, CA, Paul
Teirstein, Divina Fanning (16); Herzzentrum Universität Leipzig, Leipzig, Germany, Sven
Moebius-Winkler, Carola Doehnert (15); Our Lady of Lourdes Medical Center, Camden, NJ,
Hans Bauer, Donna Palazzo (15); Sacred Heart Medical Center, Spokane, WA, Michael Ring,
Sharon Fulton (15); Szpital Uniwersytecki, Bydgoszcz, Poland, Jacek Kubica (15); Cardiac &
Vascular Research Center of Northern Michigan, Petoskey, MI, Louis Cannon, Jennifer
LaLonde (14); CaRE Foundation, Inc., Wausau, WI, Timothy Grady, Jeff Kaliebe (14);
Bakersfield Memorial Hospital, Bakersfield, CA, Tommy Lee, Jenny Marsh (13); Catharina
Ziekenhuis, Eindhoven, The Netherlands, Jacques Koolen, Linda van Leur (13); John Radcliffe
Infirmary II, Oxford, UK, Adrian Banning, Bernadette Moreby (13); Tufts Medical Center, Boston,
MA, Carey Kimmelstiel, Vilma Castaneda (13); Herz-Kreislauf-Zentrum Segeberger Kliniken
GmbH, Bad Segeberg, Germany, Gert Richardt, Daniela Schuermann-Kuchenbrandt (12);
Maine Medical Center, Portland, ME, Mirle Kellett, Claire Berg (12); South Denver Cardiology
Associates, PC, Littleton, CO, Joseph Burchenal, Mary Soltau (12); Tallahassee Memorial
Hospital, Tallahassee, FL, Wayne Batchelor, Patty Knap (12); North Mississippi Medical Center,
Tupelo, MS, Barry Bertolet, Terri Tutor (11); Swedish Medical Center, Seattle, WA, Amish
Desai, Lauren Braam (11); Turku University Hospital, Turku, Finland, Juhani Airaksinen, Tuija
Vasankari (11); Hokkaido Social Insurance Hospital, Hokkaido, Japan, Keiichi Igarashi, Yukiko
Oshima (10); Krannert Institute of Cardiology, Indianapolis, IN, Jeffrey Breall, Judy Foltz (10);
Saiseikai Yokohama-City Eastern Hospital, Kanagawa, Japan, Toshiya Muramatsu, Yoshie
Kanbe (10); The Cardiovascular Institute Hospital, Tokyo, Japan, Junji Yajima, Kazumi Matsuda
(10); Heart Hospital of Austin, Austin, TX, Roger Gammon, Mary Robison (9); Institut
Cardiovasculaire - Paris Sud/Institut Hospitalier Jacques Cartier, Massy, France, Thomas
Hovasse, Marion Baudry (9); St. Luke's Episcopal Hospital, Houston, TX, Emerson Perin,
Gilberto DeFreitas (9); University of California, Davis Medical Center, Sacramento, CA,
Reginald Low, Janine Carlson (9); Ascot Angiography, Auckland, New Zealand, Warwick Jaffe,
Mary-Anne Lindesay and Ian Summerscales (8); Deaconess Medical Center, Spokane, WA,
Philip Huber, Jillian Ciccarello (8); James Cook University Hospital, Middlesbrough, UK, Mark
De Belder, Gill Smith (8); Kokura Memorial Hospital, Fukuoka, Japan, Hiroyoshi Yokoi, Keiko
Inoue (8); Mercy General Hospital, Sacramento, CA, Joseph Kozina, Christie Hogan (8);
Military Hospital, Wroclaw, Poland, Krzysztof Reczuch (8); Monash Medical Centre, Clayton,
Victoria, Australia, Ian Meredith, Mauro Baldi and Julie Plunkett (8); Oklahoma Foundation for
Cardiovascular Research, Oklahoma City, OK, Thomas McGarry, Stacie Hanes (8);
Rigshospitalet Copenhagen, Copenhagen, Denmark, Henning Kelbaek, Lene Kloevgaard (8);
St. Antonius Ziekenhuis, Nieuwegein, The Netherlands, Maarten Suttorp, Conny Feirabend (8);
Universitair Ziekenhuis Gent, Gent, Belgium, Yves Taeymans, Patrick Verdegem (8);
Universitatsklinik Charite Berlin, Berlin, Germany, Michael Laule, Claudia Kuhn (8); Washington
Adventist Hospital, Takoma Park, MD, Mark Turco, Denise Pond (8); Mercy Hospital Medical
Center, Des Moines, IA, Magdi Ghali, Heather Barnes (7); Nebraska Heart Institute, Lincoln,
NE, Steven Martin, Corey Godfrey (7); Providence St. Vincent Medical Center, Portland, OR,
Todd Caulfield, Ellen Muir (7); Toho University Ohashi Medical Center, Tokyo, Japan, Masato
Nakamura, Yoshiko Mori (7); Wake Forest University School of Medicine, Winston-Salem, NC,
Michael Kutcher, Teresa Young (7); Allgemeines Krankenhaus AKH, Vienna, Austria, Thomas
Neunteufl, Markus Vertesich (6); Arkansas Heart Hospital, Little Rock, AR, David Mego, Melody
Thomas (6); National Institute of Cardiology, Warsaw, Poland, Adam Witkowski (6); Sarawak
General Hospital, Sarawak, Malaysia, Kui Hian Sim, Danny Day Dudu (6); Skejby Sygehus,
Aarhus, Denmark, Leif Thuesen, Lars Joergensen (6); Amphia Ziekenhuis, Breda, The
Netherlands, Jeroen Vos, Monique de Craen-de Moor (5); Columbia University Medical
Center/New York-Presbyterian Hospital, New York, NY, Jeffrey Moses, John Kim (5); Firelands
Regional Medical Center, Sandusky, OH, Charles O'Shaughnessy, Amy Walton (5); Mayo
Clinic, Rochester, MN, Gurpreet Sandhu, Rebekah Herrmann (5); Sakurabashi Watanabe
Hospital, Osaka, Japan, Kenshi Fujii, Motoko Uehara (5); Washington University School of
Medicine, St. Louis, MO, Alan Zajarias, Michelle Myers (5); Wellington Hospital, Wellington, NZ,
Scott Harding, Diane Middleditch (5); Banner Good Samaritan Regional Medical Center,
Phoenix, AZ, Akil Loli, Hope Mangum (4); Cooper Hospital/University Medical Center, Camden,
NJ, Sanford Gips, Nancy Markiewicz (4); Genesys Regional Medical Center, Grand Blanc, MI,
David Dobies, Sandra Watt (4); Good Samaritan Hospital, Los Angeles, CA, Steven Burstein,
Cecile Mayoralgo (4); Guys and St. Thomas NHS Foundation Trust, St. Thomas Hospital,
London, UK, Martyn Thomas, Karen Wilson (4); Penn State Milton S Hershey Medical Center,
Hershey, PA, Ian Gilchrist, Patricia Frey (4); St. Luke’s Hospital/Mid America Heart Institute,
Kansas City, MO, Charles Barth III, Cheryl Rutherford (4); Sentara Norfolk General Hospital,
Norfolk, VA, Paul Mahoney, Melinda Bullivant (4); The Prince Charles Hospital, Chermside,
Queensland, Australia, Darren Walters, Lee Clement (4); Baptist Memorial Hospital, Memphis,
TN, David Wolford, Wyvonia Harris (3); Good Samaritan Hospital, Cincinnati, OH, Dogan
Temizer, Deborah Kathman (3); Lynchburg General Hospital, Lynchburg, VA, Thomas Nygaard,
Joyce White (3); Main Line Health Heart Center, Bryn Mawr, PA, Sean Janzer, Catherine
Pensyl (3); Medisch Centrum Alkmaar, Alkmaar, The Netherlands, Johannes de Swart, Yvonne
van der Meij (3); National Heart Centre Singapore, Singapore, Aaron Wong, Ding Ying Law (3);
Pinnacle Health at Harrisburg Hospital, Harrisburg, PA, Rajesh Dave, Stephanie McMullen (3);
University of California, San Diego Medical Center, San Diego, CA, Ehtisham Mahmud, Cecilia
Judd (3); Baystate Medical Center, Springfield, MA, Marc Schweiger, Judy Fleurent (2); Herzund Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany, Marcus Wiemer,
Carola Pape (2); Holy Cross Hospital, Ft. Lauderdale, FL, Alan Niederman, Sandra Vujanic (2);
Institut Jantung Negara, Kuala Lumpur, Malaysia, Robaayah Zambahari, Sabian Intan Safarinaz
(2); Jewish Hospital and St. Mary's Healthcare, Louisville, KY, Nicholaos Xenopoulos, Nancy
McDonald (2); Kaleida Health, Buffalo, NY, A.R. Zaki Masud, Theresa Giambra (2); Maimonides
Medical Center, Brooklyn, NY, Robert Frankel, Maureen Stokes-McCarthy (2); Mount Sinai
School Medical Center, New York, NY, Annapoorna Kini, Michael Fusilero (2); Missouri Baptist
Medical Center, St. Louis, MO, Clark McKenzie and Stuart Higano, Cathy Castner (2); Riverside
Methodist Hospital, Columbus, OH, Steven Yakubov, Tammy Terry (2); Royal Perth Hospital,
Perth, WA, Australia, Jamie Rankin, Clare Venn-Edmonds (2); St. Mary's Duluth Clinic Regional
Heart Center, Duluth, MN, Albert Deibele, Christine Leone (2); Teikyo University Hospital,
Tokyo, Japan, Takaaki Isshiki, Katsumasa Misawa (2); Union Memorial Hospital, Baltimore, MD,
John Wang, Judith Raqueno (2); University Hospital, Heart Centre, Tampere, Finland, Kari
Niemelä, Hannaleena Nappila (2); Universität Heidelberg, Heidelberg, Germany, Wolfgang
Rottbauer, Christiane Selter (2); Clinique St. Augustin, Bordeaux, France, Olivier Darremont,
Laetitia Reuter (1); Hospital De Santa Cruz, Lisbon, Portugal, Rui Teles, Paulo Simao (1);
Middlemore Hospital, Centre for Clinical Research and Effective Practice, Otahuhu, Auckland,
NZ, Douglas Scott, Diane Caveney (1); Royal Victoria Hospital, Belfast, UK, Ganesh
Manoharan, Bernie Smith (1); Spectrum Health Hospitals, Grand Rapids, MI, David Wohns,
Jeanine Holens (1); St. Francis Hospital, Roslyn, NY, Richard Shlofmitz, Elizabeth Haag (1);
Trinity Mother Frances Health System, Tyler, TX, Thaddeus Tolleson, Cheryl Rasor (1); William
Beaumont Hospital, Royal Oak, MI, Simon Dixon, Dorothy Richardson (1).