Supplemental Table 1 – Breakdown of recruitment by centre
Country
Centre
BRCA1+
BRCA1-
BRCA2+
BRCA2-
Grand Total
Australia
Peter MacCallum Cancer Centre, Victoria
27
18
32
21
98
Repatriation General Hospital, Adelaide
24
27
16
11
78
Prince of Wales Hospital, NSW
8
6
13
5
32
Westmead Hospital, Sydney
8
4
9
9
30
Monash Medical Centre, Victoria
10
3
7
9
29
Royal Melbourne Hospital, Victoria
10
8
3
7
28
Genetic Health Queensland
6
9
4
8
27
King Edward Memorial Hospital, WA
12
1
8
4
25
Hunter New England, NSW
7
2
10
3
22
Tasmanian Clinical Genetics Service, Hobart
0
6
4
2
12
Canada
Montreal General Hospital & Jewish General Hospital
16
5
18
7
46
Denmark
Vejle Hospital
38
1
44
2
85
Germany
University of Cologne
12
3
11
7
33
Iceland
University Hospital of Iceland, Reykjavik
0
0
6
9
15
India
Tata Memorial Cancer Centre, Mumbai
3
4
0
0
7
Ireland
Mater Hospital, Dublin
1
0
0
0
1
Israel
Chaim Shema Medical Center, Tel-Hashomer
10
0
5
0
15
Kaplan Medical Center, Rehovot
2
3
4
4
13
Italy
Istituto Nazionale dei Tumori, Milan
5
0
0
0
5
Malaysia
Cancer Research Initiatives Foundation, Kuala Lumpur
2
0
2
1
5
Norway
Norwegian Radium Hospital, Oslo
2
0
96
3
101
Poland
Pomeranian Medical University, Szczecin
77
20
0
0
97
Portugal
Portuguese Oncology Institute, Porto
10
8
13
16
47
Slovakia
National Cancer Institute, Bratislava
7
1
0
0
8
Slovenia
Institute of Oncology Ljubljana
13
4
5
6
28
Spain
Catalan Institute of Oncology, Barcelona
16
21
18
17
72
Hospital de Sant Pau, Barcelona
7
3
9
8
27
Hospital Vall d'Hebron, Barcelona
8
7
8
2
25
Sweden
Karolinska University Hospital, Stockholm
8
5
6
2
21
The Netherlands
Erasmus Medical Centre, Rotterdam
47
50
16
19
132
University Medical Centre Radboud, Nijmegen
35
45
7
20
107
University Medical Centre Groningen
25
19
15
16
75
University Medical Centre, Utrecht
15
26
9
6
56
Leiden University Medical Centre
12
17
11
11
51
Netherlands Cancer Institute
20
14
4
7
45
University Hospital Maastricht
11
15
5
14
45
Vrije University Medical Centre, Amsterdam
14
6
5
10
35
Academic Medical Centre, Amsterdam
9
6
4
3
22
Royal Marsden Hospital, London
34
18
34
13
99
St Mary’s Hospital, Manchester
28
18
27
17
90
Wessex Clinical Genetics Service, Southampton
19
19
20
9
67
Sheffield Children’s Hospital & Royal Hallamshire
Hospital
Birmingham Women’s Hospital
16
11
19
16
62
10
9
22
14
55
South East Thames Genetics Service, London
9
6
19
6
40
Yorkhill Hospital, Glasgow
4
8
15
12
39
Churchill Hospital, Oxford
15
0
19
1
35
South West Thames Genetics Service, London
8
0
21
1
30
Northern Centre for Cancer Care, Newcastle
11
2
13
3
29
Addenbrookes Hospital, Cambridge
9
2
12
5
28
North East Thames Genetics Service, London
9
1
9
1
20
United Kingdom
United States
Grand Total
Royal Devon & Exeter Hospital, Exeter
5
2
5
7
19
North West Thames Genetics Service, London
St Michael’s Hospital, Bristol
9
0
7
2
18
3
5
4
5
17
Leicester Royal Infirmary
0
2
4
2
8
The Royal Children’s Hospital & The Royal Hospital,
Liverpool
West Cumberland Hospital & Cumberland Infirmary
2
2
1
0
5
1
0
1
0
2
Derriford Hosptial, Plymouth
1
0
0
1
2
NorthShore University HealthSystem, Evanston
26
28
16
23
93
University of Utah, Salt Lake City
17
16
15
12
60
Abramson Cancer Centre, Philadelphia
12
14
18
8
52
Fox Chase Cancer Center, Philadelphia
5
0
2
1
8
MD Anderson Cancer Center, Houston
1
1
1
0
3
791
531
731
428
2481
Supplement – The IMPACT Collaborators
Coordinating Centre, Institute of Cancer Research, London: Rosalind Eeles (PI), Elizabeth
Bancroft, Elizabeth Page, Elena Castro, Natalie Taylor, Jenny Pope, Sibel Saya, Sue Martin,
Diana Keating.
Australia (*more than 1 affiliation)
Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, VIC: Gillian
Mitchell*, Kate Drew, Joanne McKinley, Lara Petelin, Morgan Murphy, Rebecca Doherty,
Sarah Pratt
The Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC: Gillian
Mitchell
Department of Urology, Peter MacCallum Cancer Centre, East Melbourne, VIC: Declan
Murphy, Laurence Cleeve
Department of Urology, Repatriation General Hospital, Daw Park, SA: Jimmy Lam, Louise
Taylor, Cathy Miller, Alan Stapleton, Michael Chong
SA Clinical Genetics Service, SA Pathology (at Women's & Children's Hospital), North
Adelaide, SA: Graeme Suthers
Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW: Katherine Tucker*,
Lesley Andrews, Jessica Duffy
Faculty of Medicine, UNSW, Sydney NSW: Katherine Tucker
Department of Urology, Prince of Wales Hospital, Randwick, NSW: Richard Millard
Hereditary Cancer Clinic, Prince of Wales Clinical School, Faculty of Medicine, UNSW,
Sydney, NSW: Robyn Ward, Rachel Williams
St Vincent's Clinic, Sydney, NSW: Phillip Stricker
Familial Cancer Service, Westmead Hospital, Wentworthville, Sydney, NSW: Judy Kirk*,
Michelle Bowman
Sydney Medical School (University of Sydney) at Westmead Millennium Institute, NSW:
Judy Kirk
Westmead Hospital, Wentworthville, Sydney, NSW: Manish Patel
Familial Cancer Centre, Monash Health , Clayton, VIC: Marion Harris, Shona O'Connell, Clare
Hunt, Courtney Smyth
Monash Medical Centre, VIC: Mark Frydenberg
Familial Cancer Centre, The Royal Melbourne Hospital, Grattan St, Parkville, VIC: Geoffrey
Lindeman*, Kylie Shackleton
Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research,
Parkville, VIC: Geoffrey Lindeman
Department of Medicine, The University of Melbourne, Parkville, VIC: Geoffrey Lindeman
Genetic Health Queensland, Royal Brisbane & Women's Hospital, Herston, QLD: Rachel
Susman, Julie McGaughran, Melanie Boon
Genetic Services of WA, King Edward Memorial Hospital, Subiaco, WA: Nicholas Pachter*,
Sharron Townshend, Lyn Schofield
Dept of Paediatrics, University of Western Australia, Perth, WA: Nicholas Pachter
Hunter Family Cancer Service, Waratah, NSW: Allan Spigelman*, Margaret Gleeson
University of New South Wales, St Vincent’s Clinical School, NSW: Allan Spigelman
Hereditary Cancer Clinic , The Kinghorn Cancer Centre, St Vincent's Hospital, Sydney, NSW:
Allan Spigelman
School of Biomedical Sciences and Pharmacy, University of Newcastle, NSW: Rodney Scott
Tasmanian Clinical Genetics Service, Hobart, TAS: David Amor*, Jo Burke, Briony Patterson,
Sonya Bacic
Murdoch Childrens Research Institute, Parkville, VIC: David Amor
Department of Paediatrics, University of Melbourne, Parkville, VIC: David Amor
Mater Private Hospitals, QLD: Peter Swindle
Victorian Cancer Biobank, Carlton, VIC
Canada
McGill University, Montreal: William Foulkes, Marc Tischkowitz, Nassim Taherian, Armen
Aprikian.
Denmark
Vejle Hospital, Vejle: Anne-Bine Skytte, Anders Bojeson, Dorthe Cruger
Fredericia and Kolding Hospital, Fredericia: Palle Osther
Odense University Hospital, Odense: Anne-Marie Gerdes
Germany
Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne:
Rita Schmutzler, Kerstin Rhiem, Kerstin Luedtke-Heckenkamp, Nicole Ochsendorf, Kerstin
Fiddike.
Iceland
University Hospital of Iceland, Reykjavik: Oskar Johannsson, Vigdis Stefansdottir
India
Tata Memorial Centre, Mumbai: Vedang Murthy, Rajiv Sarin, Kasturi Awatagiri, Sujata
Ghonge, Pradnya Kowtal, Gouri Mulgund
Ireland
Mater Private Hospital, Dublin: David Gallagher, Richard Bambury, Michael Farrell, Fergal
Gallagher
Israel
Chaim Shema Medical Center, Tel-Hashomer: Eitan Friedman
The Genetic Institute and the Urology Department, Kaplan Medical Centre, Rehovot:
Rakefet Chen-Shtoyerman, Sagi Josefsberg Ben-Yehoshua, Rachel Nissani, Zvi Appelman and
Evyatar Moriel
Italy
Istituto Nazionale dei Tumori, Milan: Nicola Nicolai, Paolo Radice, Riccardo Valdagni, Tiziana
Magnani
Malaysia
Cancer Research Initiatives Foundation, Subang Jaya Medical Centre, Selangor Darul
Ehsan: Soo Hwang Teo, Hui Meng Tan, Sook-Yee Yoon
University of Malaya, Kuala Lumpur: Soo Hwang Teo, Meow Keong Thong
The Netherlands
STOET: Stichting Opsporing Erfelijke Tumoren, Leiden
Leiden University Medical Centre, Leiden: Christi van Asperen.
Radboud University Nijmegen Medical Centre: Bart Kiemeney. Wendy van Zelst-Stams
University Medical Center Utrecht: Margreet G.E.M. Ausems, Rob B. Van der Luijt
Academic Medical Center , Amsterdam: Theo van Os
Netherlands Cancer Institute, Amsterdam: Mariëlle W.G. Ruijs
VU University Medical Center, Amsterdam: Muriel A. Adank
Erasmus Medical Center, Rotterdam: Rogier A. Oldenburg
University Hospital Maastricht : A. (Paula) T.J.M. Helderman- van den Enden
University Medical Centre Groningen: Jan C. Oosterwijk
Norway
Norwegian Radium Hospital, Oslo: Lovise Maehle, Pal Moller, Bjorn Brennhovd, Heidi
Medvik, Eldbjørg Hanslien,
Poland
International Hereditary Cancer Centre, Szczecin: Cezary Cybulski, Jan Lubinski, Dominika
Wokolorczyk
Portugal
Portuguese Oncology Institute, Porto: Manuel Teixeira, Sofia Maia, Ana Peixoto, Rui
Henrique, Jorge Oliveira, Nuno Gonçalves, Luís Araújo, Manuela Seixas, João Paulo Souto,
Pedro Nogueira
Slovakia
National Cancer Institute, Bratislava: Lucia Copakova.
Slovenia
Institute of Oncology, Ljubljana: Janez Zgajnar, Mateja Krajc, Alenka Vrecar.
Spain
Hereditary Cancer Program, Catalonian Institute of Oncology, Barcelona: Ignacio Blanco,
Mónica Salinas, Gabriel Capella
Hospital de Sant Pau, Barcelona: Teresa Ramón y Cajal, David Fisas
Hospital Vall d'Hebron, Barcelona: Judith Balmaña, Neus Gadea, Juan Morote
Sweden
Karolinska Univesity Hospital, Stockholm: Annelie Liljegren, Marie Hjälm - Eriksson, KarlJohan Ekdahl, Stefan Carlsson.
United Kingdom
Royal Marsden NHS Foundation Trust: Helen Hanson, Susan Shanley, Chee Goh, Emma
Killick, Audrey Ardern-Jones, Jennifer Wiggins, Kelly Kohut, Vincent Khoo, Nicholas Van As,
Alan Thompson, Chris Ogden, Nigel Borley, Christopher Woodhouse, Pardeep Kumar.
Manchester Regional Genetics Service, Manchester: D Gareth Evans, Barbara Bulman,
Jeanette Rothwell.
Wessex Clinical Genetics Service, Southampton: Diana Eccles, Catherine Mercer, Donna
McBride, Philandra Costello.
East Anglian Regional Genetics Service, Cambridge: Marc Tischkowitz, Joan Paterson,
Virginia Clowes, Amy Taylor, Barbara Newcombe.
Oxford Regional Genetics Service, Oxford: Lisa Walker, Dorothy Halliday, Barbara Stayner, D
Fleming-Brown
South West Thames Regional Genetics Service, London: Shirley Hodgson, Glen Brice, Tessa
Homfray, Carrie Hammond.
Peninsula Clinical Genetics Service. Exeter: Carole Brewer, Alison Potter, Caroline Renton,
Anne Searle, Kathryn Hill, Selina Goodman, Lynda Garcia, Gemma Devlin, Sarah Everest,
Maria Nadolski.
Northern Clinical Genetics Service, Newcastle: Fiona Douglas, Irene Jobson, Edgar Paez.
South West Regional Genetics Service, Bristol: Alan Donaldson, Sue Tomkins.
South East Thames Regional Genetics Service, Guys Hospital London: Louise Izatt, Gabriella
Pichert, Chris Jacobs, Caroline Langman, Michelle Weston.
North West Thames Regional Genetics Service, Harrow: Angela Brady, Virginia Clowes, Huw
Dorkins, Athalie Melville, Monika Kosicka-Slawinska, Carole Cummings, Vicki Kiesel, Marion
Bartlett, Kashmir Randhawa, Natalie Ellery
North East Thames Regional Genetics Service, NE Thames: Lucy Side, Alison Male, Kate
Simon, Katie Rees, Cecilia Compton, Lizzie Tidey.
North Trent Clinical Genetics Service, Sheffield: Jackie Cook, Louise Nevitt, Stuart Ingram
Academic Urology Unit, Sheffield: Derek Rosario, James Catto, Joanne Howson.
West Midlands Regional Clinical Genetics Service, Birmingham: Dr Kai-Ren Ong, Cyril
Chapman, Trevor Cole, Tricia Heaton, Jonathan Hoffman, Lucy Burgess
West of Scotland Genetics Service, Glasgow: Rosemarie Davidson, Mark Longmuir, Cathy
Watt, Alexis Duncan
Leicester Royal Infirmary: Julian Barwell, Roger Kockelbergh, Ayisha Sattar, Beckie Kaemba,
Zahirah Sidat, Nafisa Patel, Kas Siguake
North Cumbria University Hospitals Trust: Alex Henderson, Angela Birt, Una Poultney, Nkem
Umez-Eronini, Jaswant Mom
Royal Liverpool Children’s Hospital, Liverpool: Lynn Greenhalgh, Gillian Roberts, Anthony
Woodward, Vivienne Sutton
Royal Liverpool and Broadgreen Hospital NHS Trust, Liverpool: Philip Cornford, Katy
Treherne, Julie Griffiths
Derriford Hospital, Plymouth: Carole Brewer, Lyn Cogley
United States
NorthShore University HealthSystem, Evanston: Christina Selkirk, Peter Hulick, Wendy
Rubinstein, Charles Brendler, Brian Helfand, Michael McGuire, Karen Kaul, Daniel Shevrin,
Scott Weissman, Anna Newlin, Kristen Vogel, Shelly Weiss
Salt Lake City, Utah: Saundra Buys, David Goldgar, Tom Conner, Vickie Venne, Robert
Stephenson, Christopher Dechet
University of Pennsylvania, Philadelphia: Susan Domchek, Jacquelyn Powers
MD Anderson, Texas: Sara Strom, Banu Arun, John W. Davis, Yuko Yamamura
Fox Chase Cancer Center: Veda Giri, Laura Gross