1) Refractometry - is the method of analysis that is based on measurement of:
A. Refractive index of the test solution
B. Concentrations of substances in solution
C. Angle of polarization plane rotation
D. Optical activity of substances
E. Intensity of incident light
ANSWER: A
2) PH indication of value the solution of thiamine hydrochloride can be in the range of 2,7-3,3. To
measure this laboratory specialist uses:
A. Viscometer
B. Refractometer
C. Potentiometer
D. Polarimeter
E. Conductometer
ANSWER: C
3) Specific optical conversion of 2% methionine solution can vary from +22, 50 ° to + 24,00 °. To
calculate this quantity one should experimentally measure:
A. Optical density of the solution
B. Melting temperature of the substance
C. The rotation angle of the polarization plane
D. The solution viscosity
E. Refractive index
ANSWER: C
4) One of the tests that confirm the identity of diсhlothiazide pills is the identification of the maximum
absorption at 275 nm. Analyst of drugs quality control of the laboratory conducts this test using the
following device:
A. Refractometer
B. Photoelectrocolorimeter
C. Infrared spectrophotometer
D. UV-specrophotometer
E. Potentiometer
ANSWER: D
5) Test substance is identified by a maximum absorption at a wavelength of 232 nm, comparing with
standard sample preparation. Specify which physical chemical method is used then.
A. Refractometry
B. UV-spectrophotometry
C. Polarimetry
D. Infared spectrophotometry
E. Polarography
ANSWER: B
6) At the chromatography of novocaine in a thin layer of sorbent after the plate reveal one got a spot, the
distance to which from the start line is 3 cm and the length of the solvent front - 10 cm. What is the
value of novocaine Rf ?
A. 0,4
B. 0,5
C. 0,6
D. 0,3
E. 0,7
ANSWER: D
7) The substance identity in the TLC is determined by the value of Rf. Rf - it is:
A. Ratio of the traveled by a substance distance to the distance traveled by solvent
B. Ratio of the traveled by a substance distance to the distance traveled by the solvent at 10cm
C. The distance traveled by the substance during a certain period of time
D. Ratio of the distance traveled by the solvent to the distance traveled by a substance
E. The value of the distance traveled by a substance from the starting line.
ANSWER: A
8) Analytical chemist of control and analytical laboratory after the study of unknown medical
preparation solubility found out that the solubility of this medium is 0.2 g in 5.2 ml of water. Indicate
to which group of solubility belongs this remedy.
A. Very easily soluble
B. Easily soluble
C. Soluble
D. Moderately soluble
E. Little soluble
ANSWER: C
9) Glycerin is used in pharmaceutical practice as a base for ointments. For the experimental
determination of this substance viscosity laboratory assistant uses such device:
A. Viscometer
B. Polarimeter
C. Potentiometer
D. Refractometer
E. Conductometer
ANSWER: A
10) Melting point – is an important physical constant of drug substances. Determination of melting
temperature in pharmaceutical analysis makes it possible to confirm:
A. Number of volatilizing matters and water in substance
B. Loss in weight after drying substance
C. The quantitative content of substance
D. The identity and purity degree of substanc
E. Substance resistance to the influence of external factors
ANSWER: D
11) Definition of melting temperature is carried out by different methods. To determine the melting
temperature of solids, which have an amorphous structure, the following method is used:
A. Capillary
B. Distillation
C. Open capillary
D. Potentiometry
E. Conductometry
ANSWER: C
12) Levomycetin identification according to SPHLL X is based on determining the rotation angle of the
polarization plane of polarized light by the solution of the drug in 95% alcohol and ethyl acetate.
Specify which physical chemical method is used for this purpose.
A. Refractometry
B. Spectrophotometry in the visible spectral region
C. Polarimetry
D. Spectrophotometry in the UV-spectrum
E. Polarography
ANSWER: C
13) In case of need for drug substances identification by infrared spectroscopy laboratory is to have the
following:
A. Pharmacopoeial standard sample of the substance
B. Sample of the substance of a similar pharmacological action
C. Different dosage forms of the substance
D. Sample of a similar chemical structure substance
E. The substance firm-manufacturer permission
ANSWER: A
14) Photometric titration curve is built on the basis of photometric titration results and its coordinates are:
A. A - V titrant
B. I, mк A - V titrant
C. E, B - V titrant
D. I - V titrant
E. E - V titrant
ANSWER: A
15) Absorption spectrophotometry is a modern physical chemical method of medicines purity research.
What law is in the base of this method:
A. The passage of polarized light through the solution of optically active substance
B. Light scattering law of Buguer-Lambert-Beer
C. Nernst distribution law
D. Raley light scattering
E. Joint light absorbance law of Buguer-Lambert-Beer
ANSWER: E
16) The salt of Sodium, wetted by chloride acid and brought in a colourless flame, paints it in colour:
A. Black
B. Violet
C. Yellow
D. Green
E. Red
ANSWER: C
17) One reaction of identification for Calcium-cations in the calcium lactate is reaction with such
reagents:
A. BaCl2, HCl
B. Na2CO3, H2C4H4O6
C. CH3COOH, Na3[Co(NO2)6]
D. K[Sb(OH)6], K2CO3
E. (NH4)2C2O4, CH3COOH
ANSWER: E
18) For identification of Citrate-ions in the sodium citrate add KMnO4 solution in the medium of H2SO4
to its decolouration. A product oxidation of citric acids is:
A. Acetaldehyde
B. Ethanol
C. CO2
D. Propanol
E. Acetone
ANSWER: E
19) As initial substances for synthesis of potassium citrate use:
A. Glycerol and potassium
B. Prophanol and potassium carbonate
C. Citric acid and sodium carbonate
D. Glycerol and potassium hydroxide
E. Citric acid and potassium carbonate
ANSWER: E
20) What analytical effect of pirochemical reaction for Sodium cations in the sodium hydroxybutyrate?
A. Orange flame
B. Violet flame
C. Red flame
D. Green flame
E. Yellow flame
ANSWER: E
21) Pharmacopoeial method of assay for calcium gluconate is chelatometry, direct titration.As titrant use:
A. KMnO4
B. HCl
C. NaOH
D. ICl
E. Na-EDTA
ANSWER: E
22) Calcium gluconate in the medical practice use as agent:
A. Antimicrobial
B. Anticancer
C. Antituberculosis
D. Antiviral
E. Antiallergic
ANSWER: E
23) For identification of lactate-ion in the calcium lactate pentahydrate use reaction with potassium
permanganate solution and sulphatic acid. What analytical effect this reaction?
A. Black precipitate
B. Brown steam
C. White curde precipitate
D. Intensive violet-crimson colour
E. Decolouration of solution and smell of fresh apples
ANSWER: E
24) The chemist-analyst makes pyrochemical reaction for Calcium-cations in the calcium lactate
pentahydrate. What colour of flame he observes?
A. Yellow
B. Violet
C. Blue
D. Green
E. Orange-red
ANSWER: E
25) The method of assay for potassium acetate is acidimetry, direct titration. As titrant use:
A. CH3COOH
B. HClO4
C. H2SO4
D. HNO3
E. HCl
ANSWER: E
26) One product of reaction sodium citrate with bromine water is pentabromoacetone such colour:
A. Green
B. Grey
C. Colourless
D. Black
E. White
ANSWER: E
27) Calcium gluconate is:
A. Colourless gas
B. Crystal powder of grey colour
C. Clear liquid with yellowish shade
D. Yellow powder
E. White crystalline or the granulated powder
ANSWER: E
28) The Pharmacopoeial method of assay for calcium gluconate is:
A. Iodometry
B. Acidimetry
C. Alkalimetry
D. Chelatometry, back titration
E. Chelatometry, direct titration
ANSWER: E
29) For assay of sodium citrate use acidimetry, non-aqueous titration. Shot of sodium citrate dissolves in
the such solvent:
A. Acetic acid
B. Chloroform
C. Water
D. Perchloric acid
E. Anhydrous acetic acid
ANSWER: E
30) One method of assay for sodium hydroxybutyrate is acidimetry, non-aqueous titration. As titrant use:
A. CH3COOH
B. HNO3
C. HCl
D. H2SO4
E. HClO4
ANSWER: E
31) The method of assay for calcium lactate is chelatometry, direct titration. Equivalent weight (Em) of
calcium lactate is:
A. М m./3
B. М m./4
C. 2М. m.
D. М m./2
E. М m
ANSWER: E
32) The one possible method of assay for glutamic acid is formol titration (Serens method). As titrant
use:
A. Sodium nitrite
B. Formaldehyde solution
C. Hydrogen peroxide solution
D. Hydrochloric acid
E. Sodium hydroxide
ANSWER: E
33) The general method of assay for all amino acids is Keldal method. As titrant in this method use:
A. AgNO3
B. KBrO3
C. KMnO4
D. H2SO4
E. HCl
ANSWER: E
34) For identification of glutamic acid use polarimetry. What doing in this method?
A. Index of refraction
B. Degree of turbidity
C. Melting point
D. Osmotic pressure
E. Define a ange of rotation
ANSWER: E
35) Glutamic acid is:
A. Muddy liquid
B. A red gas
C. A colourless liquid
D. A blue amorphous powder
E. A white, crystalline powder
ANSWER: E
36) The chemical name of 2-aminopentane-1,5-dioic acid is correspond the such drug:
A. Aminalone
B. Acetylcysteine
C. Cysteine
D. Methionine
E. Glutamic acid
ANSWER: E
37) For assay of glutamic acid use alkalimetry, direct titration. As titrant use:
A. Potassium hydroxide
B. Hydrogen peroxide solution
C. Hydrochloric acid
D. Iodine solution
E. Sodium hydroxide
ANSWER: E
38) For identification of Glutamic acid use:
A. Methoxyphenyacetic acid reagent
B. Silver nitrate, nitric acid
C. Barium chloride in presence of HCl
D. Phenol in presence of HCl concentrated
E. Resorcinol in presence of H2SO4 concentrated
ANSWER: E
39) For identification of glutamic acid use:
A. Silver nitrate, nitric acid
B. Potassium permanganate
C. Solution of iron chloride
D. Nessler reagent
E. Copper sulfate with sodium hydroxide
ANSWER: E
40) Glutamic acid is:
A. Gas with characteristic smell
B. A colourless liquid
C. A yellow, crystalline powder freely soluble in cold water
D. A white, amorphous powder freely soluble in in alcohol and in ether
E. A white, crystalline powder freely soluble in boiling water
ANSWER: E
41) The chemical name of glutamic acid is:
A. 3-aminopentane-1,2-dioic acid
B. 4-aminopentane-1,5-dioic acid
C. 3-aminopentane-1,5-dioic acid
D. 2-aminohexane-1,5-dioic acid
E. 2-aminopentane-1,5-dioic acid
ANSWER: E
42) The one method of assay for methionine is iodometry, back. As indicator use:
A. Eosine
B. Potassium chromate
C. Methyl orange
D. Phenolphthalein
E. Starch solution
ANSWER: E
43) The method of assay for aminalone is acidimetry, non-aqueous titration. What solvent use for
disilution of aminalone?
A. Dioxane
B. Chloroform
C. Ether
D. Water
E. Anhydrous acetic acid
ANSWER: E
44) The chemical name of acetylcysteine is:
A. Acetic ether of glutamic acid
B. 2-Amino-3-mercaptopropanoic acid
C. 4-Aminobuturic acid
D. 2-Amino-4-methylthiobuturic acid
E. 2-Acetamino-3-mercaptopropanoic acid
ANSWER: E
45) The equivalent weight (Em) of methionine at assay by means of formol titration is:
A. М m./3
B. М m./4
C. 2 М m.
D. М m./2
E. М m.
ANSWER: E
46) Methionine belongs to group of amino acids:
A. Diaminomonocarboxylic acids
B. Diaminocarboxylic acids
C. Monoaminodicarboxylic acids
D. Diaminodicarboxylic acids
E. Monoaminocarboxylic acids
ANSWER: E
47) In the medical practice glutamic acid use for treatment of such diseases:
A. Heart
B. Nephros
C. Liver
D. Eyes
E. CNS
ANSWER: E
48) The general reaction of identification for all amino acids is reaction with:
A. Potassium hexahydroxostibate
B. Methoxyphenylacetic acid reagent
C. Ammoniac solution of AgNO3
D. Nessler reagent
E. Ninhydrin
ANSWER: E
49) What reagents used for identification of mercapto group in the molecule of acetylcysteine?
A. Barium chloride, chloride acid
B. Tartaric acid, water
C. Methoxyphenylacetic reagent
D. Silver nitrate, nitric acid
E. Sodium nitroprusside solution, ammonia solution concentrated
ANSWER: E
50) Action and use of acetylcysteine:
A. Antiseptic
B. Purgative
C. Anticancer
D. Antiviral
E. Mucolitic
ANSWER: E
51) Amino acids are structural elements:
A. Carbons
B. Fats
C. Hormones
D. Phospholipids
E. Proteins
ANSWER: E
52) The method of assay methionine is acidimetry, non-aqueous titration. Equivalence point fixed,
according to Pharmacopoeia:
A. By means of starch solution
B. By means of tropeolin 00
C. By means of potassium chromate
D. By means of idicatorless method
E. Potentiometric
ANSWER: E
53) For assay of aminalone use acidimetry, non-aqueous titration. The equivalent weight (Em) of
aminalone is:
A. 1/6 М m.
B. 2/3 М m.
C. 3 М m.
D. 2 М m.
E. М m.
ANSWER: E
54) For assay of methionine use acidimetry, non-aqueous titration. As titrant use:
A. CH3COOH
B. H2SO4
C. NaOH
D. HCl
E. HClO4
ANSWER: E
55) The method of assay for hexamethylentetramine is iodochlorometry, back titration. As titrant use:
A. NaI
B. KI
C. I2
D. ICl
E. Na2S2O3
ANSWER: E
56) The method of assay for chloral hydrate is acid-base, back titration. As titrant use:
A. HClO4
B. KOH
C. HNO3
D. H2SO4
E. HCl
ANSWER: E
57) Glycerine can be synthesed by means of hydrolysis of:
A. Acrolein
B. Ethylene
C. Propanol
D. Ethanol
E. Oils
ANSWER: E
58) The reaction of identification for aldehyde group is aurine dye formation. What reagents are used?
A. Na-nitroprussidate in the alkaline medium
B. Barium chloride in the medium of HCl
C. Ammoniacal solution of AgNO3
D. Solution of potassium ferricyanide
E. Salicylic acid in the presence of concentrated H2SO4
ANSWER: E
59) Another name of diphenhydramine hydrochloride is:
A. Ascophen
B. Piracetam
C. Analgesine
D. Metapyrin
E. Dimedrol
ANSWER: E
60) For assay of chloral hydrate use iodometry, back titration. As indicator use:
A. Starch solution
B. Tropeolin 00
C. Methyl red
D. Methyl orange
E. Phenolphthalein
ANSWER: A
61) What reagents can be used for revealing of Chloride-anions in the diphenhydramine hydrochloride?
A. КОН, HCl
B. H2O, H2SO4
C. BaCl2,HCl
D. NaOH, H2O
E. AgNO3, HNO3
ANSWER: E
62) As a medical drugt use glycerine:
A. 40 %
B. 70 %
C. 93 %
D. 100 %
E. 85 %
ANSWER: E
63) What chemical name of aether anaesthesicus (ether for a narcosis)?
A. Dimethyl ether
B. Trimethoxyboron ( methyl borate)
C. Triethoxyboron ( ethyl borate)
D. Aceto-ethyl ester
E. Diethyl ether
ANSWER: E
64) The reaction for formaldehyde synthesis is:
A. Dehydration of ethanol
B. Hydration of ethylene
C. Oxidation of methane
D. Reduction of methanol
E. Catalytic oxidation of methanol
ANSWER: E
65) For identification of formaldehyde solution use reaction with Tollens reagent. What is formed?
A. Yellow colouring
B. Intensive of dark blue colouring
C. Blue colouring
D. Red precipitate of coppper ( ) oxide
E. The dark grey precipitate of silver
ANSWER: E
66) For assay of hexamethylenetetramine use argentometry, back titration. As titrant use:
A. Barium chloride
B. Silver nitrate
C. Iron(III) ammonium sulphate
D. Silver chloride
E. Ammonium thiocyanate
ANSWER: E
67) What preparation of ethanol are pharmacopoeial (SPU)?
A. 1%
B. 9%
C. 100%
D. 10%
E. 96%
ANSWER: E
68) For identification of Potassium cations in the potassium acetate the pharmacist-analyst can used such
reagents:
A. Zinc sulphate, barium chloride
B. Sodium hydroxide, Nessler reagent
C. Sulphatic acid, acetic acid
D. Amonium oxalate, ninhydrin
E. Tartaric acid, sodium hexanitrocobaltate
ANSWER: E
69) For analysis of cysteine the chemist-analyst defined angle of rotation of polarization plane. What
instrument he used?
A. Polarograph
B. Spectrometer
C. Potentiometer
D. Refractometer
E. Polarimeter
ANSWER: E
70) The pharmacist-analyst of a drugstore makes assay for cysteine by means of iodometry, direct
titration. As indicator use:
A. Potassium chromate
B. Methyl red
C. Phenolphthalein
D. Tropeolin 00
E. Starch solution
ANSWER: E
71) The Pharmacist-analyst of a drugstore makes assay for acetylcysteine by means of iodometry, direct
titration. As titrant use:
A. KI
B. NaI
C. ICl
D. Na2S2O3
E. I2
ANSWER: E
72) The chemist-laboratorian makes the analysis of cysteine. For identification of cysteine he used
reaction with ninhydrin. What analytical effect this reaction?
A. Yellow colouring
B. White precipitate
C. Red steams
D. Black precipitate
E. Red-violet colouring
ANSWER: E
73) The chemist-analyst for the analysis cysteine used polarimeter. What value he defined?
A. Angle of light-absorption
B. Refraction angle
C. Melting point
D. рН of medium
E. Angle of rotation of polarization plane
ANSWER: E
74) The pharmacist-analyst of a drugstore makes assay for cysteine by means of iodometry, direct
titration. As titrant use:
A. KI
B. Na2S2O3
C. NaI
D. ICl
E. I2
ANSWER: E
75) The pharmacist-analyst mixed glycerol with nitric acid and superimposed potassium dichromate
solution. A color ring develops at the interface of the liquids. What colour of this ring?
A. Red
B. Black
C. White
D. Orange
E. Blue
ANSWER: E
76) The pharmacist-analyst add to water solution of diphenhydramine hydrochloride nitric acid and silver
nitrate solution. What analytical effect this reaction?
A. Yellow curde precipitate
B. Blue solution
C. Characteristic smell
D. Red gas
E. White curde precipitate
ANSWER: E
77) The pharmacist-analyst makes reaction identification of ethanol. As a result this reaction is a smell of
pears. What product of reaction have smell of pears?
A. Acetylene
B. Acetone
C. Acetate acid
D. Acetaldehyde
E. Acetic-ethyl ether
ANSWER: E
78) The pharmacist-analyst for identification of ethanol use iodoform test. As a result of reaction it is
formed:
A. Sodium iodate
B. Iodine
C. Chloroform
D. Acetaldehyde
E. Iodoform
ANSWER: E
HOH2C
79) The structural formula corresponds to a drug:
A. Calcium acetate
B. Calcium lactate
C. Calcium citrate
D. Calcium chloride
E. Calcium gluconate
ANSWER: E
OH
OH
H
OH
C
C
C
C
H
H
OH
H
COO
2+
-
Ca , H2O
2
80) The structural formula corresponds to a drug:
A. Thymol
B. Formaldehyde
C. Chlorethanol
D. Сhloramine
E. Chloral hydrate
ANSWER: E
O
H3C
CH
Ca * 5 H2O
C
O
81) The structural formula corresponds to a drug:
A. Thymol
B. Chloramine
C. Chloral hydrate
D. Formaldehyde
E. Calcium lactate
ANSWER: E
82) The structural formula corresponds to a drug:
A. Thymol
B. Chloramine
C. Chloral hydrate
D. Formaldehyde
E. Hexamethylene tetramine
OH
2
ANSWER: E
83) Determine the molecular mass of the ascorbic acid equivalent at its assay by alkalimetry, direct
titration:
A. М.m.
B. М.m./2
C. М.m./4
D. М.m./8
E. 2 М.m.
ANSWER: A
84) Choose the reagent for ascorbic acid identification:
A. Silver nitrate solution, nitrate acid
B. Dragendorff’s reagent
C. Barium chloride solution
D. 2,4-dinitrochlorbenzene
E. Hydroxylamine hydrochloride
ANSWER: A
85) Calcium ion in the calcium pangamate can be detected with following reagent:
A. Silver nitrate
B. Ammonium oxalate
C. Hydrochloric acid
D. Hydrogen peroxide
E. Potassium dichromate
ANSWER: B
86) Assay of calcium pantothenate is conducted by the following method:
A. Argentometry
B. Iodometry
C. Permanganatometry
D. Complexonometry
E. Alkalimetry
ANSWER: D
87) What compound does belong to vitamins of the alicyclic row?
A. Thiamine bromide
B. Retinol acetate
C. Vikasol
D. Ascorbic acid
E. Nicotinic acid
ANSWER: B
88) What reagents can be used for ergocalciferol identification?
A. 2,4-dinitrochlorobenzene, potassium hydroxide alcohol solution
B. Sodium nitrite, β-naphthalene alkaline solution
C. Chloral hydrate, chloroform
D. Acetylchloride, antimony (ІІІ) chloride, chloroform
E. Cerium sulfate, diphenylamine
ANSWER: D
89) Calcium pantothenate is a vitamin preparation, in the medical practice it is used under the name –
vitamin:
A. В5
B. В15
C. ВС
D. В6
E. В3
ANSWER: A
90) Retinol acetate by the chemical method can be obtained from:
A. Ergosterine
B. Fructose
C. L-streptose
D. Citral
E. Maltose
ANSWER: D
91) Ergocalciferol is used in the medical practice for the treatment of:
A. Blood diseases
B. Goiter
C. Cataract
D. Atherosclerosis
E. Rachitis
ANSWER: E
92) Assay of ascorbic acid according to the SPhU requirements is conducted by the following method:
A. Complexonometry
B. Acidimetry in non-aqueous environment
C. Alkalimetry in aqueous environment
D. Iodatomerty
E. Iodomerty
ANSWER: E
93) Ascorbic acid in industry is obtained from:
A. Furfural
B. Fructose
C. L-streptose
D. D-glucose
E. Maltose
ANSWER: D
94) Gluconic acid residue in the calcium pangamate molecule is detected by the following solution:
A. Silver nitrate
B. 2,6-dichlorophenolindophenol
C. Ammonium oxalate
D. Iron (ІІІ) chloride
E. Sodium hydroxide
ANSWER: D
95) Calcium pangamate belongs to the vitamins of:
A. Alicyclic row
B. Aromatic row
C. Aliphatic row
D. Heterocyclic row
E. Polyene row
ANSWER: C
96) Ergocalciferol also can be named as vitamin:
A. В5
B. В2
C. Е
D. D2
E. А
ANSWER: D
97) For calcium-ion detection in the calcium pangamate molecule the following reagent is used:
A. Silver nitrate
B. Glyoxal hydroxyanil
C. Hydrochloric acid
D. Hydrogen peroxide
E. Potassium dichromate
ANSWER: B
98) What medical product corresponds to the structural formula?
CH3
OH
CH
H 3C
CH3
A. Camphor
B. Midantan
C. Terpingidrat
D. Validol
E. Menthol
ANSWER: E
99) What medical product corresponds to the structural formula?
CH3
CH3
+
O
OH
O
CH
H3C
C
CH
CH3
H3C
CH3
A. Camphor
B. Medantan
C. Terpingidrat
D. Validol
E. Tropatsin(Diphenyltropine)
ANSWER: D
100) What medical product corresponds to the structural formula?
H2C
SO2OH
O
H3C
A. Terpingidrat
B. Sulfokamfokain
C. Sulfocamforic acid
D. Validol
E. Boromentol
ANSWER: C
CH3
* H2O
CH3
C
H2
CH
CH3