Douglas W. Selinger, Ph.D.
Computational Biologist
Education
• Harvard University - Ph.D. in genetics with Prof. George M. Church on, "High-resolution
microarray analysis of RNA degradation in Escherichia coli." (Ph.D. awarded Nov '02).
• Fulbright Scholar, Madrid, Spain - studied DNA-protein interactions (Sep '95 - May '96).
• Rutgers University - B.A. from Rutgers College Honors Program, graduated with honors,
GPA 3.7/4.0 Major: Molecular Biology and Biochemistry, Minor: Philosophy (Class of '95).
• Bristol University, England - Junior Year Study Abroad (Oct '93 - Jun '94).
• Bloomfield (NJ) High School - Graduated as Salutatorian, Phi Beta Kappa (Jun '91).
Research Experience
• Novartis Institutes for Biomedical Research (Cambridge, MA) I am currently a Senior
scientist/Lab head in the Life Sciences Informatics unit of the Functional Genomics
Department. I am involved in the analysis of high-throughput siRNA knockdown and cDNA
over-expression screens in mammalian cells. I am developing algorithms for data
normalization, analysis, and for the integration of multiple functional genomic data types.
(Aug '03 - Present)
• Harvard Medical School, Dept. of Genetics (Boston, MA) Developed experimental
technologies and computational analyses for subgenic resolution DNA microarray analysis.
Conducted exhaustive, detailed surveys of transcription and patterns of RNA decay in E. coli.
(Sep '97 - Aug '03).
• Kyoto Encyclopedia of Genes and Genomes, KEGG (Kyoto, Japan) Funded by the NSF
Monbusho program (Jul - Aug '01), hosted by Dr. Minoru Kanehisa at Kyoto University.
Conducted bioinformatic analysis of microarray data, interacted with KEGG database
scientists.
• Harvard Rotations: Comparative genomics (Dr. George M. Church), Bioinformatics for
large-scale two-hybrid analysis (Dr. Roger Brent), Yeast genetics (Dr. Fred Winston).
• Centro de Investigaciones Biológicas (CIB) (Madrid, Spain) Awarded Fulbright scholarship
to study Protein-DNA interactions in E. coli with Dr. Manuel Espinosa (Sep '95 - May '96).
• Hoffman-La Roche (Nutley, NJ) Lab tech, KO mouse development (Jun '95 - Aug '95).
• Waksman Institute, Rutgers University (New Brunswick, NJ) Henry Rutgers Honors
Thesis in prokaryotic transcription under Dr. Richard H. Ebright (Jun '94 - May '95).
• Merck Research Labs (Rahway, NJ) Research Internship (Summer '92 and '93).
• Structural Biology (Rutgers Univ.) Lab of Dr. Helen Berman (Mar '92 - Apr '92).
• Hoffman-La Roche (Nutley, NJ) Lab tech, Molecular Genetics Dept (Sep '90 - Aug '91).
Skills
• Unix/Linux, Perl, MATLAB, Mathematica, R, basic C++, web design.
• Fluent in Spanish (I am comfortable giving scientific lectures in Spanish.)
Teaching Experience
• Head teaching fellow, Genomics and Computational Biology, Prof. George M. Church,
Harvard & MIT (Fall '01). This graduate level course, with over 100 students, covered
experimental and computational topics in genomics, including sequence analysis, clustering,
hidden markov models, proteomics, and systems modeling.
• Teaching fellow, as above (Fall '00).
• Volunteer lecturer for "Science in the News" public lecture series (Fall '00, '01).
• Supervisor for Harvard undergraduate research (Summer '99 and '00).
• Volunteer for Boston Partners in Education, HS science class (Oct '99 - Jun '00).
Publications
• Selinger DW, Wright MA, and Church GM. "On the complete determination
of biological systems" Trends Biotechnol. Jun;21(6):251-4.
• Selinger DW, Saxena RM, Cheung KJ, Church GM, Rosenow C. Global RNA
half-life analysis in Escherichia coli reveals positional patterns of transcript
degradation. Genome Research 2003 Feb;13(2):216-23.
• Cheung KJ, Badarinarayna V, Selinger DW, Janse D, Church GM. A
microarray-based antibiotic screen identifies a regulatory role for supercoiling
in the osmotic stress response of Escherichia coli. Genome Research 2003
Feb;13(2):206-15.
• Selinger DW, Cheung KJ, Mei R, Johansson EM, Richmond CS, Blattner FR,
Lockhart DJ, Church GM. RNA expression analysis using a 30 base pair
resolution Escherichia coli genome array. Nat Biotechnol. 2000
Dec;18(12):1262-8.
• Software: Genome Array Processing Software, GAPS©, developed for high
resolution microarray analysis described in Selinger et al. (2000).
• Patel M, Selinger D, Mark GE, Hickey GJ, Hollis GF. Sequence of the dog
immunoglobulin alpha and epsilon constant region genes. Immunogenetics.
1995;41(5):282-6.
Invited Appearances & Scientific Contributions
• Invited Lecturer: International Course on the use of DNA Microarrays in Basic and Applied
Research in Mexico City, Mexico (Sep 23-27, 2002).
• Invited Speaker: Mini-symposium on "DNA Microarrays in Biology and Medicine" in
Lausanne, Switzerland (Sep 13, 2002).
• E. coli Model Cell Consortium (Emc2): represented Church lab at 1st and 2nd meetings
(Chicago - Dec '01, Mar '02). Presented E. coli genomics/bioinformatics research, helped set
goals for planned national initiative, chaired by Dr. Barry Wanner.
• CRC book proposal review: Reviewed a proposal for a bioinformatics book for CRC press.
• Invited Speaker: ASM General Meeting 2001, Orlando, Affymetrix Microbiology Workshop
(May 19, 2001).
• NSF Grant Review Panelist: Served on NSF review panel for small business grants
(SBIR/STTR) in the area of biotechnology sensing and arrays. (Mar 27-28, 2001).
• Invited Speaker: Conference enititled, "Biochemical Systems Theory and Modeling in the
Post Genomic Era: Principles of Design to Designed Benefits." in honor of Dr. Michael
Savageau (University of Michigan, Dec 2, 2000).
• Invited Panelist: NSF Workshop on "Quantitative Systems Biotechnology". Spoke on DNA
microarray design/analysis, helped draft workshop proceedings. (NSF, Sep 13-14, 2000).
• Invited Speaker: Pasteur Institute "Seminar on Algorithmics and Biology" (Pasteur Institute,
France, Mar 13-15, 2000).
Hobbies & Interests
International travel, languages, philosophy, cycling, camping, public science outreach.
Contact Info
e-mail: selinger@post.harvard.edu
web: http://genetics.med.harvard.edu/~selinger
Last updated 11-2-03
phone: (617) 617-474-9506