CV Dominique Langin
1
CURRICULUM VITAE
LANGIN Dominique, D.V.M. Ph.D.
Professor of Nutrition and Medical Biochemistry
Obesity Research Laboratory, INSERM U858, Rangueil Institute of Molecular Medicine, I2MR Inserm
U858, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4.
Tel: + 33 5 61 32 56 28 FAX: + 33 5 61 32 56 23 E-mail: dominique.langin@inserm.fr
Date and place of birth: 13 Dec. 1962, Annecy, France
Degrees
1993
1990
1988
1987
1986
Capacity to Direct Research Programs, Paul Sabatier University, Toulouse
Doctor of Science (Ph.D.), Paul Sabatier University, Toulouse. With honors
Doctor in Veterinary Medicine (D.V.M.) National Veterinary School of Nantes.
Faculty of Medicine, Nantes. With honors.
Diploma for Advanced Level Studies (M.Sc.+1 year)
University of Rennes. National Agronomic School of Rennes. Ranked first
Certificate of Veterinary Medicine Practice
Positions held
2006Professor of Nutrition and Medical Biochemistry, Purpan Faculty of Medicine
2004-2006 Hospital Interface Contract, Inserm-Toulouse University Hospitals
2000-2006 Director of Research at Inserm (National Institute of Health and Medical Research)
1993-2000 Established Investigator at CNRS (National Center for Scientific Research)
1990-1993 Visiting Scientist of the Swedish Medical Research Council
Research Associate in Molecular Endocrinology, Faculty of Medicine, Lund University
1987-1990 Research Assistant, National Institute of Agronomic Research (INRA)
1986-1987 Assistant, Department of Nutrition, National Veterinary School of Nantes
Direction of Research Laboratories
2011-
Deputy director of the Institute of Metabolic and Cardiovascular Medicine, InsermPaul Sabatier University. Head of the Obesity Research Laboratory
2006-2010 Head of the Obesity and Metabolism Department and of the Obesity Research
Laboratory at the Rangueil Institute of Molecular Medicine
2003Co-director with Prof. Vladimir Stich of the Franco-Czech Laboratory for Clinical
Research on Obesity, Inserm-3rd Faculty of Medicine, Charles University, Prague
2003-2006 Director of the Obesity Research Unit, Inserm-Paul Sabatier University
2000-2003 Coordinator of the team ‘Metabolism of adipose tissue and skeletal muscle and obesity’
Management and evaluation of research programs
2007-2011 Project board of the 7th framework project "ADAPT : Adipokines as Drug Targets to
Combat Adverse Effects of Excess Adipose Tissue "
2005-2010 Project board of the 6th framework project "Hepadip : Hepatic and adipose tissue and
functions in the metabolic syndrome"
2005-2009 Group leader for Functional Genomics in the Integrated Project DIOGENES ‘Diet,
Obesity and genes’ (6th framework).
2005
Scientific board of the Cardiovascular, Obesity and Diabetes program of the French
Agency for Research
2004-2008 Partner in the Integrated Project MolPAGE 'Molecular Phenotyping to Accelerate
Genomic Epidemiology' (6th framework).
2001-2004 Group leader for Gene Expression in the Shared-Cost Action NUGENOB ‘Nutrient-gene
interaction in human obesity’ (Key Action 1 of the 5th framework RTD program of the EU).
2003Member of the board of the Louis Bugnard Institute (also between 1994 and 1998)
2001-2006 Expert for the Department of Nutrition, Nestle Research Center, Lausanne, Switzerland
1999-2001 Coordinator of the Concerted Action FATLINK ‘Dietary fat, body weight control and
links between obesity and cardiovascular disease’ (FAIR program of the EU).
1998-2004 Head with Dr. Luc Pénicaud of the Rangueil animal core facility
CV Dominique Langin
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1996-
Reviewer of European and foreign research projects (European Commission Framework 6;
National Institutes of Health, Medical research Council, Danish Research Agency,
Wellcome Trust, Netherlands organization for scientific research NWO, Natural Sciences
and Engineering Research Council of Canada, Grant Agency of the Czech Republic,
Genome Austria, Belgium Welbio excellence program)
1998-2000 Member of the Physiology Study Section of Paul Sabatier University
1994-1997 Coordinator with Dr. Max Lafontan of the Concerted Action EUROLIP 'Impairment of
adipose tissue metabolic regulation as a generator of risk factors for cardiovascular
disease' (BIOMED I program of the EU)
Training and Teaching
Training of 11 PhD students and 17 MSc (1-year research projects) students
2006European courses on nutrigenomics and obesity (France, Netherlands, Austria)
2004Faculty of Medicine, Paul Sabatier University 'Molecular biology & Biochemistry' &
‘Nutrition’
1994Diploma for Advanced Level Studies and M.Sc. courses (Paul Sabatier University)
1990-93 Faculty of Medicine, Lund University 'Molecular and cellular biology'
1986-87 National Veterinary School of Nantes, 'Animal nutrition'
Societies and publications
International Association for the Study of Obesity
European Association for the Study of Obesity
French Association for Research and Study on Obesity (AFERO)
French speaking Association for the Study of Diabetes and Metabolic Diseases
Editorial boards of Diabetes, International Journal of Obesity, Obesity Reviews and Journal of
Nutrigenetics and Nutrigenomics
159 original publications and 52 review articles & book chapters. 6100 citations, h-index 43. Complete
list at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=langin+d[au]
Meeting organization
2012
2010
2010
2009
2008
2003
2002
2001
1997
European Congress on Obesity 2012, Lyon, France : Vice President
11th International Congress on Obesity, Stockholm, Sweden : Scientific Committee
Symposium “Adipose Tissue: a key target for prevention of the metabolic syndrome”,
Toulouse, France : Organizer
Satellite congress on Prevention of weight (re)gain of the European Congress on Obesity,
Amsterdam, The Netherlands, Scientific Committee
Symposium on adipose tissue lipolysis, Toulouse, France : Organizer
European Congress on Obesity 2003, Helsinki, Finland : Scientific Committee
9th International Congress on Obesity, Sao Paulo, Brasil : International Advisory Board
Final workshop of the Concerted Action FATLINK, Toulouse, France : Organizer
Final workshop of the Concerted Action EUROLIP, Toulouse, France : Organizer
Awards
2009
1998
1996
Laboratory award from the Fondation pour la Recherche Médicale
Andre Mayer Award of the International Association for the Study of Obesity
Young Investigator Award of the European Association for the Study of Obesity
CV Dominique Langin
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List of publications
Original articles
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Viguerie, N., Montastier, E., Roussel, B., Combes, M., Maoret, J.J., Astrup, A., Saris, W.H., Holst,
C., Clement, K., and Langin, D. 2010. Large-scale quantitative analysis of human adipose tissue
gene expression reveals biomarkers of metabolic profiles during dietary weight loss intervention.
Submitted.
Girousse, A., Tavernier, G., Monbrun, L., Bezaire, V., Moro, C., Prunet-Marcassus, B., Waget, A.,
Roussel, B., Caspar-Bauguil, S., Holm, C., et al. 2010. Impairment of Adipose Tissue Lipolysis
Due to Hormone-Sensitive Lipase Haploinsufficiency Reduces Fatty Acid Fluxes and Improves
Insulin Sensitivity Submitted.
Klimcakova, E., Roussel, B., Kovacova, Z., Kovacikova, M., Siklova-Vitkova, M., Combes, M.,
Hejnova, J., Decaunes, P., Maoret, J.J., Vedral, T., et al. 2010. Macrophage gene expression is
related to obesity and metabolic syndrome in human subcutaneous fat as well as in visceral fat.
Diabetologia in press.
Siklova-Vitkova, M., Polak, J., Klimcakova, E., Vrzalova, J., Kovacikova, M., Kovacova, Z.,
Rossmeislova, L., Hnevkovska, Z., Langin, D., and Stich, V. 2010. Effect of hyperinsulinemia and
very-low-calorie diet on interstitial cytokine levels in subcutaneous adipose tissue of obese
women. Am J Physiol Endocrinol Metab in press.
Kovacikova, M., Sengenes, C., Kovacova, Z., Siklova-Vitkova, M., Klimcakova, E., Polak, J.,
Rossmeislova, L., Bajzova, M., Hejnova, J., Hnevkovska, Z., et al. 2010. Dietary interventioninduced weight loss decreases macrophage content in adipose tissue of obese women. Int J
Obes in press.
Klimcakova, E., Roussel, B., Marquez-Quinones, A., Kovacova, Z., Kovacikova, M., Combes, M.,
Siklova-Vitkova, M., Hejnova, J., Sramkova, P., Bouloumie, A., et al. 2010. Worsening of Obesity
and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral
Adipose Tissue: Decreased Metabolism and Increased Immune Response. J Clin Endocrinol
Metab in press.
Jocken, J.W., Moro, C., Goossens, G.H., Hansen, D., Mairal, A., Hesselink, M.K., Langin, D., van
Loon, L.J., and Blaak, E.E. 2010. Skeletal Muscle Lipase Content and Activity in Obesity and
Type 2 Diabetes. J Clin Endocrinol Metab in press.
Aguilar, V., Annicotte, J.S., Escote, X., Vendrell, J., Langin, D., and Fajas, L. 2010. Cyclin G2
Regulates Adipogenesis through PPAR{gamma} Coactivation. Endocrinology in press.
Koppo, K., Larrouy, D., Marques, M.A., Berlan, M., Bajzova, M., Polak, J., Van de Voorde, J.,
Bulow, J., Lafontan, M., Crampes, F., et al. 2010. Lipid mobilization in subcutaneous adipose
tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides. Am J
Physiol Endocrinol Metab 299:E258-265.
Grau, K., Cauchi, S., Holst, C., Astrup, A., Martinez, J.A., Saris, W.H., Blaak, E.E., Oppert, J.M.,
Arner, P., Rossner, S., et al. 2010. TCF7L2 rs7903146-macronutrient interaction in obese
individuals' responses to a 10-wk randomized hypoenergetic diet. Am J Clin Nutr 91:472-479.
Marquez-Quinones, A., Mutch, D.M., Debard, C., Wang, P., Combes, M., Roussel, B., Holst, C.,
Martinez, J.A., Handjieva-Darlenska, T., Kalouskova, P., et al. 2010. Adipose tissue
transcriptome reflects variations between subjects with continued weight loss and subjects
regaining weight 6 mo after caloric restriction independent of energy intake. Am J Clin Nutr
92:975-984.
Corpeleijn, E., Petersen, L., Holst, C., Saris, W.H., Astrup, A., Langin, D., MacDonald, I.,
Martinez, J.A., Oppert, J.M., Polak, J., et al. 2010. Obesity-related polymorphisms and their
associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.
Obesity 18:1369-1377.
Ribet, C., Montastier, E., Valle, C., Bezaire, V., Mazzucotelli, A., Mairal, A., Viguerie, N., and
Langin, D. 2010. PPARα control of lipid and glucose metabolism in human white adipocytes.
Endocrinology 151:123-133.
Moro, C., Galgani, J., Luu, L., Pasarica, M., Mairal, A., Bajpeyi, S., Schmitz, G., Langin, D.,
Liebisch, G., and Smith, S. 2009. Influence of gender, obesity, and muscle lipase activity on
intramyocellular lipids in sedentary individuals. J Clin Endocrinol Metab. 94:3440-3447.
Kovacova, Z., Vitkova, M., Kovacikova, M., Klimcakova, E., Bajzova, M., Hnevkovska, Z.,
Rossmeislova, L., Stich, V., Langin, D., and Polak, J. 2009. Secretion of adiponectin multimeric
complexes from adipose tissue explants is not modified by very low calorie diet. Eur J Endocrinol
160:585-592.
CV Dominique Langin
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16. Grau, K., Hansen, T., Holst, C., Astrup, A., Saris, W.H., Arner, P., Rössner, S., Macdonald, I.,
Polak, J., Oppert, J.M., et al. 2009. Macronutrient-specific effect of FTO rs9939609 in response to
a 10-week randomized hypo-energetic diet among obese Europeans. Int J Obes 33:1227-1234.
17. Girousse, A., Tavernier, G., Tiraby, C., Lichtenstein, L., Iacovoni, J.S., Mairal, A., Villarroya, F.,
and Langin, D. 2009. Transcription of the Human Uncoupling Protein 3 Gene Is Governed by a
Complex Interplay between the Promoter and Intronic Sequences. Diabetologia 52:1638-1646.
18. de Glisezinski, I., Larrouy, D., Bajzova, M., Koppo, K., Polak, J., Berlan, M., Bulow, J., Langin, D.,
Marques, M.A., Crampes, F., et al. 2009. Adrenaline but not noradrenaline is a determinant of
exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol 587:33933404.
19. Chavey, C., Lazennec, G., Lagarrigue, S., Clape, C., Iankova, I., Teyssier, J., Annicotte, J.S.,
Schmidt, J., Mataki, C., Yamamoto, H., et al. 2009. CXC ligand 5 is an adipose-tissue derived
factor that links obesity to insulin resistance. Cell Metab 9:339-349.
20. Capel, F., Klimcakova, E., Viguerie, N., Roussel, B., Vitkova, M., Kovacikova, M., Polak, J.,
Kovacova, Z., Galitzky, J., Maoret, J.-J., et al. 2009. Macrophages and Adipocytes in Human
Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity during Calorie Restriction and
Weight Stabilization. Diabetes 58:1558-1567.
21. Bezaire, V., Mairal, A., Ribet, C., Lefort, C., Girousse, A., Jocken, J., Laurencikiene, J., Anesia,
R., Rodriguez, A.M., Ryden, M., et al. 2009. Contribution of Adipose Triglyceride Lipase and
Hormone-sensitive Lipase to Lipolysis in Human hMADS Adipocytes. J. Biol. Chem. 284:1828218291.
22. Bezaire, V., Mairal, A., Anesia, R., Lefort, C., and Langin, D. 2009. Chronic TNFalpha and cAMP
Pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and
stimulated lipolysis. FEBS Lett. 583:3045-3049.
23. Bajzova, M., Kovacikova, M., Vitkova, M., Klimcakova, E., Polak, J., Kovacova, Z., Viguerie, N.,
Vedral, T., Mikulasek, L., Sramkova, P., et al. 2009. Retinol-binding protein 4 expression in
visceral and subcutaneous fat in human obesity. Physiol Res 57:927-934.
24. Skogsberg, J., Dicker, A., Ryden, M., Astrom, G., Nilsson, R., Bhuiyan, H., Vitols, S., Mairal, A.,
Langin, D., Alberts, P., et al. 2008. ApoB100-LDL acts as a metabolic signal from liver to
peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3:e3771.
25. Polak, J., Kovacova, Z., Holst, C., Verdich, C., Astrup, A., Blaak, E., Patel, K., Oppert, J.M.,
Langin, D., Martinez, J.A., et al. 2008. Total adiponectin and adiponectin multimeric complexes in
relation to weight loss-induced improvements in insulin sensitivity in obese women: the
NUGENOB study. Eur J Endocrinol 158:533-541.
26. Mazzucotelli, A., Ribet, C., Castan-Laurell, I., Daviaud, D., Guigne, C., Langin, D., and Valet, P.
2008. The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse
adipocytes. Regul Pept 150:33-37.
27. Laurencikiene, J., Stenson, B.M., Arvidsson Nordstrom, E., Agustsson, T., Langin, D., Isaksson,
B., Permert, J., Ryden, M., and Arner, P. 2008. Evidence for an important role of CIDEA in human
cancer cachexia. Cancer Res 68:9247-9254.
28. Larrouy, D., Barbe, P., Valle, C., Dejean, S., Pelloux, V., Thalamas, C., Bastard, J.P., Le Bouil,
A., Diquet, B., Clement, K., et al. 2008. Gene expression profiling of human skeletal muscle in
response to stabilized weight loss. Am J Clin Nutr 88:125-132.
29. Kovacikova, M., Vitkova, M., Klimcakova, E., Polak, J., Hejnova, J., Bajzova, M., Kovacova, Z.,
Viguerie, N., Langin, D., and Stich, V. 2008. Visfatin expression in subcutaneous adipose tissue
of pre-menopausal women: relation to hormones and weight reduction. Eur J Clin Invest 38:516522.
30. Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C.,
Basdevant, A., Stich, V., Viguerie, N., et al. 2008. Adipose tissue transcriptomic signature
highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol
9:R14.
31. Cauchi, S., Choquet, H., Gutierrez-Aguilar, R., Capel, F., Grau, K., Proenca, C., Dina, C., Duval,
A., Balkau, B., Marre, M., et al. 2008. Effects of TCF7L2 polymorphisms on obesity in European
populations. Obesity (Silver Spring) 16:476-482.
32. Capel, F., Viguerie, N., Vega, N., Dejean, S., Arner, P., Klimcakova, E., Martinez, J.A., Saris,
W.H., Holst, C., Taylor, M., et al. 2008. Contribution of energy restriction and macronutrient
composition to changes in adipose tissue gene expression during dietary weight-loss programs in
obese women. J Clin Endocrinol Metab 93:4315-4322.
33. Vitkova, M., Klimcakova, E., Kovacikova, M., Valle, C., Moro, C., Polak, J., Hanacek, J., Capel,
F., Viguerie, N., Richterova, B., et al. 2007. Plasma levels and adipose tissue mRNA expression
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of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not
related to diet-induced changes in insulin sensitivity. J. Clin. Endocrinol. Metab. 92:2330-2335.
Tiraby, C., Tavernier, G., Capel, F., Mairal, A., Crampes, F., Rami, J., Pujol, C., Boutin, J.A., and
Langin, D. 2007. Resistance to high fat diet-induced obesity and sexual dimorphism in metabolic
responses of transgenic mice with moderate uncoupling protein-3 overexpression in glycolytic
skeletal muscles. Diabetologia 50:2190-2199.
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L.M., Uldry, M., Tavernier, G., Langin, D., and
Spiegelman, B.M. 2007. Transcriptional control of brown fat determination by PRDM16. Cell
Metabolism 6:38-54.
Ryden, M., Jocken, J., van Harmelen, V., Dicker, A., Hoffstedt, J., Wiren, M., Blomqvist, L.,
Mairal, A., Langin, D., Blaak, E.E., et al. 2007. Comparative Studies of the Role of Hormone
Sensitive Lipase and Adipose Triglyceride Lipase in Human Fat Cell Lipolysis. Am J Physiol
Endocrinol Metab 292:E1847-E1855.
Polak, J., Moro, C., Klimcakova, E., Kovacikova, M., Bajzova, M., Vitkova, M., Kovacova, Z.,
Sotornik, R., Berlan, M., Viguerie, N., et al. 2007. The atrial natriuretic peptide- and
catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid
and hyperthyroid patients. Am J Physiol Endocrinol Metab 293:E246-251.
Pillard, F., Moro, C., Harant, I., Garrigue, E., Lafontan, M., Berlan, M., Crampes, F., de
Glisezinski, I., and Riviere, D. 2007. Lipid Oxidation According to Intensity and Exercise Duration
in Overweight Men and Women. Obesity (Silver Spring) 15:2256-2262.
Mutch, D.M., Temanni, M.R., Henegar, C., Combes, F., Pelloux, V., Holst, C., Sorensen, T.I.,
Astrup, A., Martinez, J.A., Saris, W.H., et al. 2007. Adipose gene expression prior to weight loss
can differentiate and weakly predict dietary responders. PLoS ONE 2:e1344.
Moro, C., Klimcakova, E., Lolmede, K., Berlan, M., Lafontan, M., Stich, V., Bouloumie, A.,
Galitzky, J., Arner, P., and Langin, D. 2007. Atrial natriuretic peptide inhibits the production of
adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous
adipose tissue. Diabetologia 50:1038-1047.
Mazzucotelli, A., Viguerie, N., Tiraby, C., Annicotte, J.S., Mairal, A., Klimcakova, E., Lepin, E.,
Delmar, P., Dejean, S., Tavernier, G., et al. 2007. The Transcriptional Coactivator PGC-1 and
the Nuclear Receptor PPAR Control the Expression of Glycerol Kinase and Metabolism Genes
Independently of PPAR Activation in Human White Adipocytes. Diabetes 56:2467-2475.
Laurencikiene, J., van Harmelen, V., Arvidsson Nordstrom, E., Dicker, A., Blomqvist, L., Naslund,
E., Langin, D., Arner, P., and Ryden, M. 2007. NF-kappa B is important for TNF-alpha -induced
lipolysis in human adipocytes. J Lipid Res 48:1069-1077.
Klimcakova, E., Moro, C., Mazzucotelli, A., Lolmede, K., Viguerie, N., Galitzky, J., Stich, V., and
Langin, D. 2007. Profiling of adipokines secreted from human subcutaneous adipose tissue in
response to PPAR agonists. Biochem Biophys Res Commun 358:897-902.
Jocken, J.W., Langin, D., Smit, E., Saris, W.H., Valle, C., Hul, G.B., Holm, C., Arner, P., and
Blaak, E.E. 2007. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is
decreased in the obese insulin-resistant state. J Clin Endocrinol Metab 92:2292-2299.
Boon, N., Hul, G.B., Stegen, J.H., Sluijsmans, W.E., Valle, C., Langin, D., Viguerie, N., and Saris,
W.H. 2007. An intervention study of the effects of calcium intake on faecal fat excretion, energy
metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins. Int J Obes
(Lond) 31:1704-1712.
Blaak, E.E., Hul, G., Verdich, C., Stich, V., Martinez, J.A., Petersen, M., Feskens, E.F., Patel, K.,
Oppert, J.M., Barbe, P., et al. 2007. Impaired fat-induced thermogenesis in obese subjects: the
NUGENOB study. Obesity (Silver Spring) 15:653-663.
Taleb, S., Van Haaften, R., Henegar, C., Hukshorn, C., Cancello, R., Pelloux, V., Hanczar, B.,
Viguerie, N., Langin, D., Evelo, C., et al. 2006. Microarray profiling of human white adipose tissue
after exogenous leptin injection. Eur J Clin Invest 36:153-163.
Sorensen, T.I., Boutin, P., Taylor, M.A., Larsen, L.H., Verdich, C., Petersen, L., Holst, C.,
Echwald, S.M., Dina, C., Toubro, S., et al. 2006. Genetic Polymorphisms and Weight Loss in
Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets. PLoS Clin Trials
1:e12.
Santos, J.L., Boutin, P., Verdich, C., Holst, C., Larsen, L.H., Toubro, S., Dina, C., Saris, W.H.,
Blaak, E.E., Hoffstedt, J., et al. 2006. Genotype-by-nutrient interactions assessed in European
obese women : A case-only study. Eur J Nutr 45:454-462.
Polak, J., Klimcakova, E., Moro, C., Viguerie, N., Berlan, M., Hejnova, J., Richterova, B., Kraus,
I., Langin, D., and Stich, V. 2006. Effect of aerobic training on plasma levels and subcutaneous
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abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor
necrosis factor alpha in obese women. Metabolism 55:1375-1381.
Mairal, A., Langin, D., Arner, P., and Hoffstedt, J. 2006. Human adipose triglyceride lipase is not
regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia 49:16291636.
Langin, D. 2006. Adipose tissue lipolysis as a metabolic pathway to define pharmacological
strategies against obesity and the metabolic syndrome. Pharmacol. Res. 53:482-491.
Klimcakova, E., Polak, J., Moro, C., Hejnova, J., Majercik, M., Viguerie, N., Berlan, M., Langin, D.,
and Stich, V. 2006. Dynamic strength training improves insulin sensitivity without altering plasma
levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin
Endocrinol Metab 91:5107-5112.
Boon, N., Hul, G.B., Sicard, A., Kole, E., Van Den Berg, E.R., Viguerie, N., Langin, D., and Saris,
W.H. 2006. The effects of increasing serum calcitriol on energy and fat metabolism and gene
expression. Obesity (Silver Spring) 14:1739-1746.
Blaak, E.E., Hul, G., Verdich, C., Stich, V., Martinez, A., Petersen, M., Feskens, E.F., Patel, K.,
Oppert, J.M., Barbe, P., et al. 2006. Fat oxidation before and after a high fat load in the obese
insulin-resistant state. J Clin Endocrinol Metab 91:1462-1469.
Viguerie, N., Vidal, H., Arner, P., Holst, C., Avizou, S., Astrup, A., Saris, W.H.M., MacDonald, I.A.,
Klimcakova, E., Clément, K., et al. 2005. Adipose tissue gene expression in obese subjects
during low-fat and high-fat hypocaloric diets. Diabetologia 48:123-131.
Tavernier, G., Gimenez, M., Giacobino, J.P., Hulo, N., Lafontan, M., Muzzin, P., and Langin, D.
2005. Norepinephrine induces lipolysis in 1/ 2/ 3-adrenoceptor knockout mice. Mol
Pharmacol 68:793-799.
Taleb, S., Lacasa, D., Bastard, J.P., Poitou, C., Cancello, R., Pelloux, V., Viguerie, N., Benis, A.,
Zucker, J.D., Bouillot, J.L., et al. 2005. Cathepsin S, a novel biomarker of adiposity: relevance to
atherogenesis. FASEB J. 19:1540-1542.
Polak, J., Moro, C., Klimcakova, E., Hejnova, J., Majercik, M., Viguerie, N., Langin, D., Lafontan,
M., Stich, V., and Berlan, M. 2005. Dynamic strength training improves insulin sensitivity and
functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose
tissue of obese subjects. Diabetologia 48:2631-2640.
Poitou, C., Viguerie, N., Stich, V., Liu, Y.-M., Gauthier, E., Courtine, M., Zucker, J.D., Barsh, G.S.,
Saris, W.H.M., Basdevant, A., et al. 2005. Serum amyloid A and obesity. Diabetologia 48:519528.
Petersen, M., Taylor, M.A., Saris, W.H.M., Verdich, C., Toubro, S., MacDonald, I.A., Rössner, S.,
Stich, V., Guy-Grand, B., Langin, D., et al. 2005. Randomised, multi-centre trial of two
hypoenergetic diets with different fat content in obese subjects. Int J Obes 30:552-560.
Langin, D., Dicker, A., Tavernier, G., Hoffstedt, J., Mairal, A., Ryden, M., Arner, E., Sicard, A.,
Jenkins, C.M., Viguerie, N., et al. 2005. Adipocyte lipases and defect of lipolysis in human
obesity. Diabetes 54:3190-3197.
Kaaman, M., Rydén, M., Axelsson, T., Nordström, E.A., Sicard, A., Bouloumié, A., Langin, D.,
Arner, P., and Dahlman, I. 2005. ALOX5AP expression is dependent on body weight but gene
haplotypes are not associated with obesity or insulin resistance. Int. J. Obesity 30:447-452.
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux,
V., Hugol, D., Bouillot, J.L., et al. 2005. Reduction of macrophage infiltration and chemoattractant
gene expression changes in white adipose tissue of morbidly obese subjects after surgeryinduced weight loss. Diabetes 54:2277-2286.
Boon, N., Hul, G.B.J., Viguerie, N., Sicard, A., Langin, D., and Saris, W.H.M. 2005. The effects of
three diets with various calcium contents on 24-hour energy-expenditure, fat oxidation and
adipose tissue mRNA expression of lipid-metabolism related proteins. Am J Clin Nutr 82:12441252.
Abella, A., Dubus, P., Malumbres, M., Rane, S.G., Kiyokawa, H., Sicard, A., Vignon, F., Langin,
D., Barbacid, M., and Fajas, L. 2005. Cdk4 promotes adipogenesis through PPAR gamma
activation. Cell Metabolism 2:239-249.
Viguerie, N., Clement, K., Barbe, P., Courtine, M., Benis, A., Larrouy, D., Hanczar, B., Pelloux, V.,
Poitou, C., Khalfallah, Y., et al. 2004. In vivo epinephrine-mediated regulation of gene expression
in human skeletal muscle. J. Clin. Endocrinol. Metab. 89:2000-2014.
Vallet-Erdtmann, V., Tavernier, G., Contreras, J.A., Mairal, A., Rieu, C., Touzalin, A.M., Holm, C.,
Jégou, B., and Langin, D. 2004. The testicular form of hormone-sensitive lipase HSLtes confers
rescue of male infertility in HSL-deficient mice. J. Biol. Chem. 279:42875-42880.
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69. Richterova, B., Stich, V., Moro, C., Polak, J., Klimcakova, E., Majercik, M., Harant, I., Viguerie, N.,
Crampes, F., Langin, D., et al. 2004. Effect of endurance training on adrenergic control of lipolysis
in adipose tissue of obese women. J Clin Endocrinol Metab 89:1325-1331.
70. Liu, Y.-M., Moldes, M., Bastard, J.P., Bruckert, E., Viguerie, N., Hainque, B., Basdevant, A.,
Langin, D., Pairault, J., and Clément, K. 2004. Adiponutrin: A new gene regulated by energy
balance in human adipose tissue. J. Clin. Endocrinol. Metab. 89:2684-2689.
71. Lindvall, H., Nevsten, P., Strom, K., Wallenberg, R., Sundler, F., Langin, D., Winzell, M.S., and
Holm, C. 2004. A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells. J.
Biol. Chem. 279:3828-3836.
72. Garaulet, M., Viguerie, N., Porubsky, S., Klimcakova, E., Clement, K., Langin, D., and Stich, V.
2004. Adiponectin gene expression and plasma values in obese women during very-low calorie
diet. Relationship with cardiovascular risk factors and insulin resistance. J. Clin. Endocrinol.
Metab. 89:756-760.
73. Clément, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C.A., Sicard, A., Rome, S.,
Benis, A., Zucker, J.D., et al. 2004. Weight loss regulates inflammation-related genes in white
adipose tissue of obese subjects. FASEB J. 18:1657-1669.
74. Arvidsson, E., Viguerie, N., Andersson, I., Verdich, C., Langin, D., and Arner, P. 2004. Effects of
different hypocaloric diets on protein secretion from adipose tissue of obese women. Diabetes
53:1966-1971.
75. Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D., and Langin, D. 2003.
Acquirement of brown fat cell features by human white adipocytes. J. Biol. Chem. 278:3337033376.
76. Tavernier, G., Toumaniantz, G., Erfanian, M., Heymann, M., Laurent, K., Langin, D., and
Gauthier, C. 2003. 3-adrenergic stimulation produces ex vivo a decrease of cardiac contractility
in mice overexpressing the human 3-adrenergic receptor. Cardiovasc. Res. 59:288-296.
77. Tan, G., Debard, C., Tiraby, C., Humphreys, S., Frayn, K.N.F., Langin, D., Vidal, H., and Karpe,
D. 2003. A "futile cycle" induced by thiazolidinediones in adipose tissue ? Nature Med. 9:811-812.
78. Ray, H., Beylot, M., Arner, P., Larrouy, D., Langin, D., Holm, C., and Large, V. 2003. The
presence of a catalytically inactive form of hormone-sensitive lipase is associated with decreased
lipolysis in abdominal subcutaneous adipose tissue of obese subjects. Diabetes 52:1417-1422.
79. Mauriege, P., Martel, C., Langin, D., Lacaille, M., Despres, J.P., Belanger, A., Labrie, F., and
Deshaies, Y. 2003. Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism.
Metabolism 52:264-272.
80. Lucas, S., Tavernier, G., Tiraby, C., Mairal, A., and Langin, D. 2003. Expression of human
hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but
does not enhance in vitro lipolysis. J. Lipid Res. 44:154-163.
81. Liu, Y.-M., Lacorte, J.M., Viguerie, N., Poitou, C., Pelloux, V., Guy-Grand, B., Langin, D.,
Basdevant, A., and Clément, K. 2003. Adiponectin gene expression in subcutaneous adipose
tissue of obese women in response to short-term very low calorie diet and refeeding. J. Clin.
Endocrinol. Metab. 88:5181-5186.
82. Grober, J., Lucas, S., Sörhede-Winzell, M., Zaghini, I., Mairal, A., Contreras, J.A., Besnard, P.,
Holm, C., and Langin, D. 2003. Hormone-sensitive lipase is a cholesterol esterase of the
intestinal mucosa. J. Biol. Chem. 278:6510-6515.
83. Viguerie, N., Millet, L., Avizou, S., Vidal, H., Larrouy, D., and Langin, D. 2002. Regulation of
human adipocyte gene expression by thyroid hormone. J Clin Endocrinol Metab 87:624-629.
84. Stich, V., Marion-Latard, F., Hejnova, J., Viguerie, N., Lefort, C., Suljkovicova, H., Langin, D.,
Lafontan, M., and Berlan, M. 2002. Hypocaloric diet reduces exercise-induced 2-adrenergic
antilipolytic effect and 2-adrenergic receptor mRNA levels in adipose tissue of obese women. J.
Clin. Endocrinol. Metab. 87:1274-1281.
85. Smih, F., Rouet, P., Lucas, S., Mairal, A., Sengenes, C., Lafontan, M., Vaulont, S., Casado, M.,
and Langin, D. 2002. Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose.
Diabetes 51:293-300.
86. Mairal, A., Melaine, N., Laurell, H., Grober, J., Stenson Holst, L., Guillaudeux, T., Holm, C.,
Jégou, B., and Langin, D. 2002. Characterization of a novel testicular form of human hormonesensitive lipase. Biochem Biophys Res Commun 291:286-290.
87. Clément, K., Viguerie, N., Diehn, M., Alizadeh, A., Barbe, P., Thalamas, C., Storey, J.D., Brown,
P.O., Barsh, G.S., and Langin, D. 2002. In vivo regulation of human skeletal muscle gene
expression by thyroid hormone. Genome Res. 12:281-291.
88. Raclot, T., Holm, C., and Langin, D. 2001. A role for hormone-sensitive lipase in the selective
mobilization of adipose tissue fatty acids. Biochim Biophys Acta 1532:88-96.
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89. Raclot, T., Holm, C., and Langin, D. 2001. Fatty acid specificity of hormone-sensitive lipase and
its implication in the selective hydrolysis of adipose tissue triacylglycerols. J. Lipid Res. 42:20492057.
90. Moniotte, S., Vaerman, J.L., M., K.M., D., L., Langin, D., Noirhomme, P., and Balligand, J.L.
2001. Real-time RT-PCR for the detection of beta-adrenoceptor messenger RNAs in small
human endomyocardial biopsies. J. Mol. Cell. Cardiol. 33:2121-2133.
91. Karlsson, M., Reue, K., Xia, Y.R., Lusis, A.J., Langin, D., Tornqvist, H., and Holm, C. 2001. Exonintron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene
272:11-18.
92. Blaise, R., Guillaudeux, T., Tavernier, G., Daegelen, D., Evrard, B., Mairal, A., Holm, C., Jégou,
B., and Langin, D. 2001. Testis hormone-sensitive lipase expression in spermatids is governed by
a short promoter in transgenic mice. J. Biol. Chem. 276:5109-5115.
93. Barbe, P., Larrouy, D., Boulanger, C., Chevillotte, E., Viguerie, N., Thalamas, C., Oliva Trastoy,
M., Roques, M., Vidal, H., and Langin, D. 2001. Triiodothyronine-mediated upregulation of UCP2
and UCP3 gene expression in human skeletal muscle without coordinated induction of
mitochondrial respiratory chain genes. FASEB J. 15:13-15. 10.1096/fj.1000-0502fje.
94. Mauriège, P., Langin, D., Montminy, V., Martel, C., Després, J.P., Bélanger, A., Labrie, F., and
Deshaies, Y. 2000. Effect of a long-term percutaneous adrenal steroid treatment on rat adipose
tissue metabolism. Int J Obes 24(S2):S148-S150.
95. Laurell, H., Contreras, J.A., Castan, I., Langin, D., and Holm, C. 2000. Analysis of the
psychrotolerant property of hormone-sensitive lipase through site-directed mutagenesis. Protein
Eng 13:711-717.
96. Khalfallah, Y., Fages, S., Laville, M., Langin, D., and Vidal, H. 2000. Regulation of uncoupling
protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal
muscle and subcutaneous adipose tissue. Diabetes 49:25-31.
97. Gauthier, C., Leblais, V., Moniotte, S., Langin, D., and Balligand, J.L. 2000. The negative
inotropic action of catecholamines: role of beta3- adrenoceptors. Can J Physiol Pharmacol
78:681-690.
98. Viguerie-Bascands, N., Saulnier-Blache, J.S., Dandine, M., Dauzats, M., Daviaud, D., and
Langin, D. 1999. Increase in uncoupling protein-2 mRNA expression by BRL49653 and
bromopalmitate in human adipocytes. Biochem Biophys Res Commun 256:138-141.
99. Vidal, H., Langin, D., Andreelli, F., Millet, L., Larrouy, D., and Laville, M. 1999. Lack of skeletal
muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects. Am
J Physiol 277:E830-E837.
100. Pizzinat, N., Marti, L., Remaury, A., Leger, F., Langin, D., Lafontan, M., Carpene, C., and Parini,
A. 1999. High expression of monoamine oxidases in human white adipose tissue: evidence for
their involvement in noradrenaline clearance. Biochem Pharmacol 58:1735-1742.
101. Montastruc, J.L., Verwaerde, P., Pelat, M., Galitzky, J., Langin, D., Lafontan, M., and Berlan, M.
1999. Peripheral cardiovascular actions of SR 58611 A, a beta 3-adrenoceptor agonist, in the
dog: lack of central effect. Fundam Clin Pharmacol 13:180-186.
102. Mauriege, P., Imbeault, P., Langin, D., Lacaille, M., Almeras, N., Tremblay, A., and Despres, J.P.
1999. Regional and gender variations in adipose tissue lipolysis in response to weight loss. J
Lipid Res 40:1559-1571.
103. Leblais, V., Demolombe, S., Vallette, G., Langin, D., Baro, I., Escande, D., and Gauthier, C. 1999.
beta3-adrenoceptor control the cystic fibrosis transmembrane conductance regulator through a
cAMP/protein kinase A-independent pathway. J Biol Chem 274:6107-6113.
104. Larrouy, D., Vidal, H., Andreelli, F., Laville, M., and Langin, D. 1999. Cloning and mRNA tissue
distribution of human PPARgamma coactivator-1. Int J Obes Relat Metab Disord 23:1327-1332.
105. Large, V., Reynisdottir, S., Langin, D., Fredby, K., Klannemark, M., Holm, C., and Arner, P. 1999.
Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat
cells of obese subjects. J Lipid Res 40:2059-2066.
106. Langin, D., Larrouy, D., Barbe, P., Millet, L., Viguerie-Bascands, N., Andreelli, F., Laville, M., and
Vidal, H. 1999. Uncoupling protein-2 (UCP2) and uncoupling protein-3 (UCP3) expression in
adipose tissue and skeletal muscle in humans. Int J Obes 23 Suppl 6:S64-S67.
107. Gauthier, C., Tavernier, G., Trochu, J.N., Leblais, V., Laurent, K., Langin, D., Escande, D., and Le
Marec, H. 1999. Interspecies differences in the cardiac negative inotropic effects of beta3adrenoceptor agonists. J Pharmacol Exp Ther 290:687-693.
108. Clément, K., Dina, C., Basdevant, A., Chastang, N., Pelloux, V., Lahlou, N., Berlan, M., Langin,
D., Guy-Grand, B., and Froguel, P. 1999. A sib-pair analysis study of 15 candidate genes in
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French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.
Diabetes 48:398-402.
109. Blaise, R., Grober, J., Rouet, P., Tavernier, G., Daegelen, D., and Langin, D. 1999. Testis
expression of hormone-sensitive lipase is conferred by a specific promoter that contains four
regions binding testicular nuclear proteins. J Biol Chem 274:9327-9334.
110. Barbe, P., Galitzky, J., Thalamas, C., Langin, D., Lafontan, M., Senard, J.M., and Berlan, M.
1999. Increase in epinephrine-induced responsiveness during microgravity simulated by headdown bed rest in humans. J Appl Physiol 87:1614-1620.
111. Raclot, T., Dauzats, M., and Langin, D. 1998. Regulation of hormone-sensitive lipase expression
by glucose in 3T3- F442A adipocytes. Biochem Biophys Res Commun 245:510-513.
112. Millet, L., Vidal, H., Larrouy, D., Andreelli, F., Laville, M., and Langin, D. 1998. mRNA expression
of the long and short forms of uncoupling protein-3 in obese and lean humans. Diabetologia
41:829-832.
113. Magré, J., Laurell, H., Fizames, C., Antoine, P.J., Dib, C., Vigouroux, C., Bourut, C., Capeau, J.,
Weissenbach, J., and Langin, D. 1998. Human hormone-sensitive lipase: genetic mapping,
identification of a new dinucleotide repeat, and association with obesity and NIDDM. Diabetes
47:284-286.
114. Large, V., Arner, P., Reynisdottir, S., Grober, J., Van Harmelen, V., Holm, C., and Langin, D.
1998. Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells. J
Lipid Res 39:1688-1695.
115. Klannemark, M., Orho, M., Langin, D., Laurell, H., Holm, C., Reynisdottir, S., Arner, P., and
Groop, L. 1998. The putative role of the hormone-sensitive lipase gene in the pathogenesis of
Type II diabetes mellitus and abdominal obesity. Diabetologia 41:1516-1522.
116. De Glisezinski, I., Crampes, F., Harant, I., Berlan, M., Hejnova, J., Langin, D., Riviere, D., and
Stich, V. 1998. Endurance training changes in lipolytic responsiveness of obese adipose tissue.
Am J Physiol 275:E951-E956.
117. Contreras, J.A., Danielsson, B., Johansson, C., Osterlund, T., Langin, D., and Holm, C. 1998.
Human hormone-sensitive lipase: expression and large-scale purification from a
baculovirus/insect cell system. Protein Expr Purif 12:93-99.
118. Bonnet, M., Faulconnier, Y., Flechet, J., Hocquette, J.F., Leroux, C., Langin, D., Martin, P., and
Chilliard, Y. 1998. Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and
hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows. Reprod Nutr
Dev 38:297-307.
119. Barbe, P., Millet, L., Larrouy, D., Galitzky, J., Berlan, M., Louvet, J.P., and Langin, D. 1998.
Uncoupling protein-2 messenger ribonucleic acid expression during very-low-calorie diet in obese
premenopausal women. J Clin Endocrinol Metab 83:2450-2453.
120. Stich, V., Harant, I., De Glisezinski, I., Crampes, F., Berlan, M., Kunesova, M., Hainer, V.,
Dauzats, M., Riviere, D., Garrigues, M., et al. 1997. Adipose tissue lipolysis and hormonesensitive lipase expression during very-low-calorie diet in obese female identical twins. J Clin
Endocrinol Metab 82:739-744.
121. Reynisdottir, S., Dauzats, M., Thorne, A., and Langin, D. 1997. Comparison of hormone-sensitive
lipase activity in visceral and subcutaneous human adipose tissue. J Clin Endocrinol Metab
82:4162-4166.
122. Reynisdottir, S., Angelin, B., Langin, D., Lithell, H., Eriksson, M., Holm, C., and Arner, P. 1997.
Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial
combined hyperlipidemia and insulin resistance syndrome. Arterioscler Thromb Vasc Biol
17:2287-2292.
123. Raclot, T., Langin, D., Lafontan, M., and Groscolas, R. 1997. Selective release of human
adipocyte fatty acids according to molecular structure. Biochem J 324:911-915.
124. Raclot, T., Groscolas, R., Langin, D., and Ferre, P. 1997. Site-specific regulation of gene
expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 38:19631972.
125. Millet, L., Vidal, H., Andreelli, F., Larrouy, D., Riou, J.P., Ricquier, D., Laville, M., and Langin, D.
1997. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean
humans. J Clin Invest 100:2665-2670.
126. Laurell, H., Grober, J., Vindis, C., Lacombe, T., Dauzats, M., Holm, C., and Langin, D. 1997.
Species-specific alternative splicing generates a catalytically inactive form of human hormonesensitive lipase. Biochem J 328:137-143.
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127. Grober, J., Laurell, H., Blaise, R., Fabry, B., Schaak, S., Holm, C., and Langin, D. 1997.
Characterization of the promoter of human adipocyte hormone-sensitive lipase. Biochem J
328:453-461.
128. Galitzky, J., Langin, D., Verwaerde, P., Montastruc, J.L., Lafontan, M., and Berlan, M. 1997.
Lipolytic effects of conventional beta 3-adrenoceptor agonists and of CGP 12,177 in rat and
human fat cells: preliminary pharmacological evidence for a putative beta 4-adrenoceptor. Br J
Pharmacol 122:1244-1250.
129. Tavernier, G., Barbe, P., Galitzky, J., Berlan, M., Caput, D., Lafontan, M., and Langin, D. 1996.
Expression of beta3-adrenoceptors with low lipolytic action in human subcutaneous white
adipocytes. J Lipid Res 37:87-97.
130. Stenson Holst, L., Langin, D., Mulder, H., Laurell, H., Grober, J., Bergh, A., Mohrenweiser, H.W.,
Edgren, G., and Holm, C. 1996. Molecular cloning, genomic organization, and expression of a
testicular isoform of hormone-sensitive lipase. Genomics 35:441-447.
131. Shimada, F., Makino, H., Hashimoto, N., Iwaoka, H., Taira, M., Nozaki, O., Kanatsuka, A., Holm,
C., Langin, D., and Saito, Y. 1996. Detection of an amino acid polymorphism in hormonesensitive lipase in Japanese subjects. Metabolism 45:862-864.
132. Plée-Gauthier, E., Grober, J., Duplus, E., Langin, D., and Forest, C. 1996. Inhibition of hormonesensitive lipase gene expression by cAMP and phorbol esters in 3T3-F442A and BFC-1
adipocytes. Biochem. J. 318:1057-1063.
133. Hellström, L., Reynisdottir, S., Langin, D., Rössner, S., and Arner, P. 1996. Regulation of lipolysis
in fat cells of obese women during long-term hypocaloric diet. Int. J. Obesity 20:745-752.
134. Hellström, L., Langin, D., Reynisdottir, S., Dauzats, M., and Arner, P. 1996. Adipocyte lipolysis in
normal weight subjects with obesity among first-degree relatives. Diabetologia 39:921-928.
135. Gauthier, C., Tavernier, G., Charpentier, F., Langin, D., and Le Marec, H. 1996. Functional beta3adrenoceptor in the human heart. J Clin Invest 98:556-562.
136. Fortun-Lamothe, L., Langin, D., and Lafontan, M. 1996. Influence of prolactin on in vivo and in
vitro lipolysis in rabbits. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 115:141-147.
137. Atgie, C., Tavernier, G., D'Allaire, F., Bengtsson, T., Marti, L., Carpene, C., Lafontan, M.,
Bukowiecki, L.J., and Langin, D. 1996. Beta3-adrenoceptor in guinea pig brown and white
adipocytes: low expression and lack of function. Am J Physiol 271:R1729-R1738.
138. Tavernier, G., Galitzky, J., Valet, P., Remaury, A., Bouloumie, A., Lafontan, M., and Langin, D.
1995. Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in
rat adipocytes. Am J Physiol 268:E1135-E1142.
139. Reynisdottir, S., Langin, D., Carlstrom, K., Holm, C., Rossner, S., and Arner, P. 1995. Effects of
weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity.
Clin Sci 89:421-429.
140. Remaury, A., Laurell, H., Grober, J., Reynisdottir, S., Dauzats, M., Holm, C., and Langin, D. 1995.
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29.
Biochem Biophys Res Commun 207:175-182.
141. Laurell, H., Grober, J., Holst, L.S., Holm, C., Mohrenweiser, H.W., and Langin, D. 1995. The
hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1-- >13.2 is not duplicated
on 19p13.3. Int J Obes 19:590-592.
142. Holm, C., Belfrage, P., Osterlund, T., Davis, R.C., Schotz, M.C., and Langin, D. 1994. Hormonesensitive lipase: structure, function, evolution and overproduction in insect cells using the
baculovirus expression system. Protein Eng 7:537-541.
143. Langin, D., Laurell, H., Holst, L.S., Belfrage, P., and Holm, C. 1993. Gene organization and
primary structure of human hormone-sensitive lipase: possible significance of a sequence
homology with a lipase of Moraxella TA144, an antarctic bacterium. Proc Natl Acad Sci U S A
90:4897-4901.
144. Langin, D., and Holm, C. 1993. Sequence similarities between hormone-sensitive lipase and five
prokaryotic enzymes. Trends Biochem Sci 18:466-467.
145. Frayn, K.N., Langin, D., Holm, C., and Belfrage, P. 1993. Hormone-sensitive lipase: quantitation
of enzyme activity and mRNA level in small biopsies of human adipose tissue. Clin Chim Acta
216:183-189.
146. Cousin, B., Casteilla, L., Lafontan, M., Ambid, L., Langin, D., Berthault, M.F., and Penicaud, L.
1993. Local sympathetic denervation of white adipose tissue in rats induces preadipocyte
proliferation without noticeable changes in metabolism. Endocrinology 133:2255-2262.
147. Langin, D., Portillo, M., Dauzats, M., and Lafontan, M. 1992. Drop in the "atypical" betaadrenergic response and modification of the beta/alpha 2-adrenoceptor balance in fat cells from
aging rabbits. Endocrinology 130:307-315.
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148. Langin, D., Ekholm, D., Ridderstrale, M., Lafontan, M., and Belfrage, P. 1992. cAMP-dependent
protein kinase activation mediated by beta 3-adrenergic receptors parallels lipolysis in rat
adipocytes. Biochim Biophys Acta 1135:349-352.
149. Lafontan, M., Langin, D., Portillo, M., and Paris, H. 1992. Imidazoline binding sites in fat cells.
Localization and pharmacological differentiation from alpha2-adrenergic receptors. Am J
Hypertens 5:72S-79S.
150. Portillo, M., Reverte, M., Langin, D., Senard, J.M., Tran, M.A., Berlan, M., and Montastruc, J.L.
1991. Effect of a 7-day treatment with idazoxan and its 2-methoxy derivative RX 821002 on alpha
2-adrenoceptors and non-adrenoceptor idazoxan binding sites in rabbits. Br J Pharmacol
104:190-194.
151. Langin, D., Portillo, M.P., Saulnier-Blache, J.S., and Lafontan, M. 1991. Coexistence of three
beta-adrenoceptor subtypes in white fat cells of various mammalian species. Eur J Pharmacol
199:291-301.
152. Langin, D., Portillo, M., Saulnier-Blache, J.-S., and Lafontan, M. 1991. Functional demonstration
of the coexistence of three -adrenergic receptor subtypes in mammal white fat cells with
BRL37344 and CGP12177. In The pharmacology of adrenoceptors. E. Szabadi, and C.
Bradshaw, editors. Basel: Birkhauser Verlag. 305-306.
153. Senard, J.M., Langin, D., Estan, L., and Paris, H. 1990. Identification of alpha 2-adrenoceptors
and non-adrenergic idazoxan binding sites in rabbit colon epithelial cells. Eur J Pharmacol
191:59-68.
154. Paris, H., Voisin, T., Remaury, A., Rouyer-Fessard, C., Daviaud, D., Langin, D., and Laburthe, M.
1990. Alpha-2 adrenoceptor in rat jejunum epithelial cells: characterization with [3H]RX821002
and distribution along the villus-crypt axis. J Pharmacol Exp Ther 254:888-893.
155. Langin, D., Paris, H., and Lafontan, M. 1990. Binding of [ 3H]idazoxan and of its methoxy
derivative [3H]RX821002 in human fat cells: [3H]idazoxan but not [3H]RX821002 labels additional
non-alpha 2-adrenergic binding sites. Mol Pharmacol 37:876-885.
156. Langin, D., Paris, H., Dauzats, M., and Lafontan, M. 1990. Discrimination between alpha 2adrenoceptors and [3H]idazoxan-labelled non-adrenergic sites in rabbit white fat cells. Eur J
Pharmacol 188:261-272.
157. Carpene, C., Galitzky, J., Larrouy, D., Langin, D., and Lafontan, M. 1990. Non-adrenergic sites
for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304
in rat adipocytes. Biochem Pharmacol 40:437-445.
158. Saulnier-Blache, J.S., Carpene, C., Langin, D., and Lafontan, M. 1989. Imidazolinic radioligands
for the identification of hamster adipocyte alpha 2-adrenoceptors. Eur J Pharmacol 171:145-157.
159. Langin, D., Nguyen, P., Dumon, H., and Malek, A. 1989. Aldehydes and ketones in silage:
quantitative analysis by high performance liquid chromatography. Ann Rech Vet 20:119-127.
160. Langin, D., Lafontan, M., Stillings, M.R., and Paris, H. 1989. [3H]RX821002: a new tool for the
identification of alpha 2A- adrenoceptors. Eur J Pharmacol 167:95-104.
161. Langin, D., and Lafontan, M. 1989. [3H]idazoxan binding at non-alpha2-adrenoceptors in rabbit
adipocyte membranes. Eur J Pharmacol 159:199-203.
Review articles
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8.
Langin, D. 2010. Adipose tissue lipolysis revisited (again!): lactate involvement in insulin
antilipolytic action. Cell Metab 11:242-243.
Langin, D. 2010. Recruitment of brown fat and conversion of white into brown adipocytes:
Strategies to fight the metabolic complications of obesity? Biochim Biophys Acta 1801:372-376.
Kolditz, C.I., and Langin, D. 2010. Adipose tissue lipolysis. Curr Opin Clin Nutr Metab Care
13:377-381.
Klimcakova, E., Kovacikova, M., Stich, V., and Langin, D. 2010. Adipokines and dietary
interventions in human obesity. Obes Rev 11:446-456.
Lafontan, M., and Langin, D. 2009. Lipolysis and lipid mobilization in human adipose tissue. Prog
Lipid Res 48:275-297.
Henegar, C., Taleb, S., Langin, D., Zucker, J.D., and Clément, K. 2009. Application of ‘Omic’
strategies to Obesity Research. In Peptides in Energy Balance and Obesity. G. Frühbeck, editor.
Bezaire, V., and Langin, D. 2009. Regulation of adipose tissue lipolysis revisited. Proc. Nutr. Soc.
68:350-360.
Frayn, K.N., Langin, D., and Karpe, F. 2008. Fatty acid-induced mitochondrial uncoupling in
adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative
capacity is increased. Diabetologia 51:394-397.
CV Dominique Langin
9.
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Clement, K., and Langin, D. 2007. Regulation of inflammation-related genes in human adipose
tissue. J. Intern. Med. 262:422-430.
10. Arner, P., and Langin, D. 2007. The role of neutral lipases in human adipose tissue lipolysis. Curr
Opin Lipidol 18:246-250.
11. Mazzucotelli, A., and Langin, D. 2006. La mobilisation des acides gras et leur utilisation dans le
tissu adipeux :
une nouvelle donne. J Soc Biol 200:83-91.
12. Langin, D., and Arner, P. 2006. Importance of TNFalpha and neutral lipases in human adipose
tissue lipolysis. Trends Endocrinol Metab 17:314-320.
13. Langin, D. 2006. Control of fatty acid and glycerol release in adipose tissue lipolysis. C R
Biologies 329:598-607.
14. Langin, D. 2006. Adipose tissue lipolysis as a metabolic pathway to define pharmacological
strategies against obesity and the metabolic syndrome. Pharmacol. Res. 53:482-491.
15. Viguerie, N., Poitou, C., Cancello, R., Stich, V., Clement, K., and Langin, D. 2005.
Transcriptomics applied to obesity and caloric restriction. Biochimie 87:117-123.
16. Tiraby, C., and Langin, D. 2005. PGC-1alpha, un co-activateur transcriptionnel impliqué dans le
métabolisme. médecine/sciences 21:49-54.
17. Kaput, J., Ordovas, J.M., Ferguson, L., van Ommen, B., Rodriguez, R.L., Allen, L., Ames, B.N.,
Dawson, K., German, B., Krauss, R., et al. 2005. The case for strategic international alliances to
harness nutritional genomics for public and personal healthdagger. Br J Nutr 94:623-632.
18. Langin, D., and Lafontan, M. 2004. Lipolysis and lipid mobilization in human adipose tissue. In
Handbook of obesity. Etiology and Pathology. G. Bray, and C. Bouchard, editors. New York:
Marcel Dekker. 515-532.
19. Frayn, K.N., and Langin, D. 2004. Triacylglycerol metabolism in adipose tissue. In Lipobiology. G.
van der Vusse, editor. Amsterdam: Elsevier. 337-356.
20. Viguerie, N., and Langin, D. 2003. Effect of thyroid hormone on gene expression. Curr Op Nutr
Metab Care 6:377-381.
21. Valet, P., Boucher, J., Lucas, S., Tavernier, G., Castan-Laurell, I., and Langin, D. 2003. Etude
des tissus adipeux par transgenèse. In Pour une approche scientifique de l'obésité. A.
Basdevant, and D. Ricquier, editors. Paris: Elsevier. 159-174.
22. Tiraby, C., and Langin, D. 2003. Conversion from white to brown adipocytes: a strategy for the
control of fat mass? Trends Endocrinol Metab 14:439-441.
23. Langin, D., Viguerie, N., Barbe, P., Larrouy, D., and Clement, K. 2003. Regulation of human
adipose tissue and skeletal muscle gene expression by thyroid hormone. In Progress in Obesity
Research 9. G. Medeiros-Neto, A. Halpern, and C. Bouchard, editors. London: John Libbey
Eurotext. 117-121.
24. Langin, D. 2003. The role of uncoupling protein 2 in the development of type 2 diabetes. Drugs
Today 39:287-295.
25. Valet, P., Tavernier, G., Castan-Laurell, I., Saulnier-Blache, J.S., and Langin, D. 2002.
Understanding adipose tissue development from transgenic animal models. J Lipid Res 43:835860.
26. Langin, D., and Lafontan, M. 2001. Fat cell lipolysis in the new millenium. Obesity Matters 4:7-10.
27. Langin, D. 2001. Nouvelles pistes dans l'étude de la lipolyse adipocytaire chez l'homme. Journ
Annu Diabetol Hotel Dieu:119-127.
28. Langin, D. 2001. Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J
Med 345:1772-1774.
29. Langin, D., Lucas, S., and Lafontan, M. 2000. Millenium fat cell lipolysis reveals unsuspected
novel tracks. Horm. Metab. Res. 32:443-452.
30. Lafontan, M., Sengenes, C., Galitzky, J., Berlan, M., De Glisezinski, I., Crampes, F., Stich, V.,
Langin, D., Barbe, P., and Riviere, D. 2000. Recent developments on lipolysis regulation in
humans and discovery of a new lipolytic pathway. Int J Obes Relat Metab Disord 24:S47-52.
31. Lafontan, M., Langin, D., Galitzky, J., Berlan, M., Gauthier, C., and Tavernier, G. 2000. 3adrenoceptor-mediated responses in heart and vessels. In The 3-adrenoceptor. A. Strosberg,
editor. London: Taylor & Francis. 87-96.
32. Gauthier, C., Langin, D., and Balligand, J.L. 2000. 3-Adrenoceptors in the cardiovascular
system. Trends Pharmacol Sci 21:426-431.
33. Langin, D. 1999. Control of hormone-sensitive lipase and uncoupling protein expression. In
Progress in Obesity Research. B. Guy-Grand, and G. Ailhaud, editors. London: John Libbey. 97104.
CV Dominique Langin
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34. Lafontan, M., Langin, D., Valet, P., Saulnier-Blache, J.-S., Galitzky, J., Carpéné, C., and Berlan,
M. 1999. Adrenergic receptors in brown and white adipocytes : structure, function and regulation.
In Progress in Obesity Research. B. Guy-Grand, and G. Ailhaud, editors: John Libbey. 365-371.
35. Lafontan, M., and Langin, D. 1998. Régulation neuro-humorale de la lipolyse : aspects
physiologiques et pathologiques. médecine/sciences 8-9:865-876.
36. Galitzky, J., Langin, D., Montastruc, J.L., Lafontan, M., and Berlan, M. 1998. On the presence of
a putative fourth beta-adrenoceptor in human adipose tissue [letter; comment]. Trends Pharmacol
Sci 19:164-166.
37. Langin, D., and Gauthier, C. 1997. Le poids des faits: réponse. Médecine/Sciences 13:285-286.
38. Lafontan, M., Barbe, P., Galitzky, J., Tavernier, G., Langin, D., Carpene, C., Bousquet-Melou, A.,
and Berlan, M. 1997. Adrenergic regulation of adipocyte metabolism. Hum Reprod 12 Suppl 1:620.
39. Holm, C., Langin, D., Manganiello, V., Belfrage, P., and Degerman, E. 1997. Regulation of
hormone-sensitive lipase activity in adipose tissue. Methods Enzymol 286:45-67.
40. Langin, D., Holm, C., and Lafontan, M. 1996. Adipocyte hormone-sensitive lipase: a major
regulator of lipid metabolism. Proc Nutr Soc 55:93-109.
41. Langin, D., and Gauthier, C. 1996. Le récepteur 3-adrénergique humain: le coeur et la raison.
Médecine/Sciences 12:1253-1256.
42. Fortun-Lamothe, L., Langin, D., and Lafontan, M. 1996. Influence of prolactin on lipolysis in
rabbits. In 6th World Rabbit Congress. F. Lebas, editor. Lempdes: Association Française de
Cuniculture. 167-170.
43. Langin, D., Tavernier, G., and Lafontan, M. 1995. Regulation of beta 3-adrenoceptor expression
in white fat cells. Fundam Clin Pharmacol 9:97-106.
44. Lafontan, M., and Langin, D. 1995. Cellular aspects of fuel mobilization and selection in white
adipocytes. Proc Nutr Soc 54:49-63.
45. Lafontan, M., Bousquet-Melou, A., Galitzky, J., Barbe, P., Carpene, C., Langin, D., Berlan, M.,
Valet, P., Castan, I., Bouloumie, A., et al. 1995. Adrenergic receptors and fat cells: differential
recruitment by physiological amines and homologous regulation. Obes Res 3 Suppl. 4:507S514S.
46. Lafontan, M., Bouloumié, A., Valet, P., Castan, I., Langin, D., Galitzky, J., Carpéné, C., Barbe, P.,
Tavernier, G., Saulnier-Blache, J.-S., et al. 1995. Differential activation and regulation of fat cell
adrenoceptors controlling hormone-sensitive lipase activation. In Progress in obesity research 94.
G. Bray, editor. London: John Libbey & Co Ltd. 95-102.
47. Lafontan, M., Langin, D., and Tavernier, G. 1994. Thyroid hormones and adipose tissues. In The
thyroid and tissues. J. Orgiazzi, J. Leclère, and U. Hostalek, editors. Stuttgart, Germany:
Schattauer. 79-85.
48. Langin, D. 1993. Organisation du gène de la lipase hormono-sensible et adaptation au froid de
l'enzyme. médecine/sciences 10:126.
49. Lafontan, M., Saulnier-Blache, J.-S., Carpene, C., Langin, D., Galitzky, J., Portillo, M., Larrouy,
D., and Berlan, M. 1991. Fat cell adrenergic receptors: from molecular approaches to therapeutic
strategies. In Obesity in Europe. G. Ailhaud, B. Guy-Grand, M. Lafontan, and D. Ricquier, editors:
John Libbey & Company Ltd. 141-153.
50. Lafontan, M., Langin, D., Portillo, M., Saulnier-Blache, S., Quideau, N., and Valet, P. 1991.
Regulation of lipolysis by catecholamines and neuropeptides: Recent developments. In Progress
in Obesity Research 1990. Y. Oomura, S. Tarui, S. Inoue, and S. T, editors. London: John Libbey
& Company Ltd. 245-246.
51. Lafontan, M., Galitzky, J., Saulnier-Blache, J.-S., Mauriège, P., Taouis, M., Langin, D., Carpene,
C., Valet, P., and Berlan, M. 1990. Recent developments in human fat cell adrenergic-receptor
characterization: interests and limits of animal and cellular models for regulation studies. In
Obesity: towards a molecular approach. I. Alan R. Liss, editor. 173-188.
52. Langin, D., Dumon, H., NGuyen, P., Malek, A., and Fromageot, D. 1988. Composés carbonylés
dans les ensilages: potentialités toxiques. Une revue. Revue Méd. Vét. 139:407-415.