Central Research Forum Tuesday March 10, 2009 Program 12:00 Noon – 2:00 p.m. Apollo (Multipurpose) Room 160 Student Union 2:00 p.m. – 2:10 p.m. Discovery Room 163 Student Union 2:10 p.m. – 3:15 p.m. Discovery Room 163 Student Union Poster Set-up Howard Part, M.D. Dean, Boonshoft School of Medicine SESSION 1: NEW INVESTIGATORS AT WRIGHT STATE UNIVERSITY David Ladle, Ph.D. Assistant Professor of Neuroscience, Cell Biology, and Physiology “Transcriptional Regulation of Synaptic Connectivity to Motor Neurons” Yong-Jie Xu, Ph.D. Assistant Professor of Biochemistry and Molecular Biology “Molecular Mechanism of the DNA Replication Checkpoint in Fission Yeast” Rosalyn Scott, M.D. Professor of Surgery “Collaborating with the College of Engineering - Initial Strategies and Early Outcomes” 3:15 p.m. – 3:30 p.m. Break 3:30 p.m. – 4:40 p.m. Discovery Room 163 Student Union SESSION 2: TRANSLATIONAL RESEARCH AT WRIGHT STATE UNIVERSITY Steven Berberich, Ph.D. Professor and Chair of Biochemistry and Molecular Biology KEYNOTE PRESENTATION “Translational Research: From Bench to Bedside” Michael Johnson, M.D. Associate Professor of Surgery “Translational Research in Regenerative Medicine” 4:40 p.m. – 5:00 p.m. Discovery Room 163 Student Union 5:00 p.m. – 7:00 p.m. Apollo (Multipurpose) Room 160 Student Union Sonia Michail, M.D. Associate Professor of Pediatrics “The Human Gut Microbiome” Data Blitz Robert W. Putnam, Ph.D. Professor of Neuroscience, Cell Biology and Physiology Reception and Poster Session Posters/Alpha Listing Poster # Name Patricia Abboud 37 26, 27, 28, 29 Lawrence S. Amesse 5 Ana Benito Gonzalez 64 Nicole Borges 48 Subbaraju Budharaju Poster # Name Shihong Mao 47 57 Erin McConnell 22 Kelly Miller 30 Marvin Miller 52, 53 Ann Morrison 21 Katie Bullinger 58 Gary Nieder 43 Ruth Chambers-Turner 36 Oleg Paliy 41 Richard Chou 59 John Pearson 39 Raminta Daniulaityte 25 Lawrence Prochaska 7 Avik Das 54 Brenda Roman 1 Adam Deardorff 14 Eric Romer 32, 33 Mauricio Di Fulvio 13 Douglas Downey 12 David Ellis 49 Tharu Fernando 46 Shannon Romer 42 Richard Salisbury 60, 61, 62, 63 Nathaniel Schlicher 3 Alok Sharma 44 Ryan Finnan 50 Valerie Siembab 16 Gordana Gataric 38 Patrick Sonner 56 Donald Gronbeck 9 Chanel Hagler 2 Adrienne Stolfi 65, 66 Raymond Ten Eyck 55 David Hart 4 Amber Todd 18 Heidi Jordan 8 Brian Tucker 23 Kevin Kelley 40 Rebecca Tuttle 34 Michael Kent 11 Christopher Vaiana 19 J. Ashot Kozak 45 Sapna Varia 20 Kashmira Kulkarni-Datar 15 Gary Ventolini 35 Miryoung Lee 6 Andrew Whitlatch 31 Mary Leonard 10 Chris Wyatt 17 Guangze Li 51 Zhongyu Yan 24 Ke-yong Li Poster Session 1. Adam Deardorff (Neuroscience, Cell Biology, and Physiology) R. Tracy, J. Roebel, B. Walmsley and R.E.W. Fyffe Calcium Binding Proteins in Brainstem Auditory Nuclei of Normal and Deaf (dn/dn) Mice 2. Adrienne Stolfi (Pediatrics) Jonathan C. Labbe, Sara E. Thompson, S. J. Gentry and Arthur S. Pickoff The Relationship Between Physical Fitness and Body Habitus in School Age Children- The "Partners for School Health" Program, Cleveland, Ohio 3. Alok Sharma (Biomedical Sciences Ph.D. Program) Sapna Varia, Athanasios Bubulya and Paula A. Bubulya Probing Functions for SON in Nuclear Structure and Gene Expression 4. Amber Todd (Biochemistry and Molecular Biology) Kevin Kelley, Kelly Miller and Steven Berberich YPEL3 Expression is Induced by the p53 Family 5. Ana Benito-Gonzalez (Neuroscience, Cell Biology and Physiology) Maria C. Berrocal, Martyn Goulding and Francisco J. Alvarez Renshaw Cells are V1-Derived Neurons with a Very Early Birth Date 6. Andrew Whitlatch (Biochemistry and Molecular Biology) Ramakrishna Kommagani and Madhavi Kadakia p73 is Essential for Vitamin D Mediated Osteoblastic Differentiation 7. Avik Das (Pharmacology and Toxicology) Shuzhen Chen,Wenfeng Zhang, Jinju Wang, Mariana Morris and Yanfang Chen Enlarged Ischemic Damage and Decreased Expression of SDF-1a in the Brain of db/db Diabetic Mice 8. Brian Tucker (Neuroscience, Cell Biology and Physiology) James Olson The Role of Glutamate on Hippocampal Tissue Swelling During Oxidative Stress 9. Chanel Hagler (Neuroscience, Cell Biology and Physiology) Kashmira Kulkarni-Datar, Jonathan Stamper, David Cool, Daniel Ketcha and Thomas L. Brown Effect of Methylation on Anti-apoptotic Activity of Cell Death Inhibitors 10. Chris Wyatt (Neuroscience, Cell Biology and Physiology) Drew C. Burlon, Heidi L. Jordan, Barbara L. Barr and Andrew W. Jenkins Presynaptic Regulation of Isolated Neonatal Rat Carotid Body Type I Cells by Histamine 11. Christopher Valana (Biochemistry and Molecular Biology) Athanasios Bubulya, Madhavi Kadakia, Larry Drummy and Rajesh Naik Functional Nanoparticles for Wound Healing Applications 12. David Ellis (Pharmacology and Toxicology) Tharu Fernando and Courtney Sulentic TCDD Inhibits Transcriptional Activation of the 3'IgHRR and hs3a/hs1,2 Enhancers in a Transgenic Lymphoma Cell Line 13. Douglas Downey (Surgery) Benjamin Monson, Karyn Butler, Gerald Fortuna, Ronald Markert and Jonathon Saxe Does Administration of Platelets Change Outcomes in Head Injured Patients Receiving Antiplatelet Therapy? 14. Eric Romer (Pharmacology and Toxicology) Courtney Sulentic Hydrogen Peroxide Modulates IgH Transcription via a 3' Regulatory Region 15. Gary Ventolini (Obstetrics and Gynecology) R. Neiger and T.J. Genrich Pregnancy Outcome After Placement of "Rescue" Shirodkar Cerclage 16. Gordana Gataric (Geriatrics) Amy Sipp, Blair Rowley and Larry Lawhorne Efficacy of a New Gyroscope-based Sensor in Detecting Pre-fall Postural Sway 17. Guangze Li (Emergency Medicine) Shuzhen Chen, Wenfeng Zhang, Yanfeng Chen and James E. Olson Increased Brain Swelling and Cell Death Following In Vitro Ischemia in Human Rennin and Angiotensinogen Double Transgenic Mice 18. Heidi Jordan (Neuroscience, Cell Biology and Physiology) Barbara L. Barr, Benoit Viollet, A. Mark Evans and Christopher N. Wyatt Knockout of AMP-Activated Protein Kinase Alpha 2 Subunits Disrupts the Hypoxic Ventilatory Response in Mice 19. J. Ashot Kozak (Neuroscience, Cell Biology and Physiology) Cation Channels Expressed In Human Lymphocytes 20. Kashmira Kulkami-Datar (Neuroscience, Cell Biology and Physiology) Amy Gultice and Thomas L. Brown Hypoxia Inducible Factor-1alpha Mediates Oxygen-dependent Inhibition of Trophoblast Cell Differentiation 21. Katie Bullinger (Neuroscience, Cell Biology and Physiology) Paul Nardelli, Qing-Bo Wang, Mark Rich and Timothy Cope Oxaliplatin Chemotherapy Alters Encoding Behavior of Proprioceptive Afferents 22. Kelly Miller (Biochemistry and Molecular Biology) Steven Berberich HdmX Overexpression Inhibits Oncogenic Ras Induced Premature Senescence 23. Kevin Kelly (Biochemistry and Molecular Biology) Kelly Miller, Amy Kelley, Amber Rosenberg, Rebecca Tuttle, Meldrick Mpagi, Katherine Heminger and Steven J. Berberich YPEL3, a Novel p53 Regulated Gene with Growth Suppressive Activity 24. Ke-yong Li (Neuroscience, Cell Biology and Physiology) Robert W. Putnam Multiple pH-sensitive Potassium Channels in Chemosensitive Neurons from the Locus Coeruleus 25. Lawrence Prochaska (Biochemistry and Molecular Biology) Teresa Cvetkov and Robert Gennis Functionality of Single-Cytsteine Mutants in Subunit III of Rhodobacter sphaeroides Cytochrome c Oxidase 26. Lawrence S. Amesse (Obstetrics and Gynecology) Teresa Pfaff-Amesse and Thomas Brown HOX Gene Expression in Transforming Growth Factor Beta-Induced Differentiation of Labyrinthine Trophoblast Stem Cell Line SM-10 27. Lawrence S. Amesse (Obstetrics and Gynecology) James A. French, Zaira Moreno, Nancy Duffy and Teresa Pfaff-Amesse Early Natural History of Menorrhagia in Adolescents with Platelet Function Disorders and Their Treatment Outcomes 28. Lawrence S. Amesse (Obstetrics and Gynecology) Austin Findlay and Teresa Pfaff-Amesse Endometrial Ablation for Menorrhagia Control in Developmentally Delayed Adolescents: A Case Series Comparison of Techniques and Outcomes 29. Lawrence S. Amesse (Obstetrics and Gynecology) Teresa Pfaff-Amesse, William T. Gunning, Nancy Duffy, Philip Jones and James A. French Menorrhagia in Adolescents with Platelet Function Disorders: Family History Suggests Further Investigations 30. Marvin Miller (Pediatrics) Laurence Kleiner Klüver-Bucy Syndrome in a Child with Neurofibromatosis-type 1 31. Mary Leonard (Biochemistry and Molecular Biology) Vandana Payal, Ramakrishna Kommagani, Lindsey Mayo and Madhavi P. Kadakia PTEN Expression is Negatively Regulated by DeltaNp63alpha 32. Mauricio Di Fulvio (Pharmacology and Toxicology) T. Garzon-Muvdi, S. Mao and F. Javier Alvarez-Leefmans 5'-UTR Splicings of NKCC2 Transcripts and an Additional Promoter in the NKCC2 Gene 33. Mauricio Di Fulvio (Pharmacology and Toxicology) T. Garzon-Muvdi, B. Raval and F. Javier Alvarez-Leefmans Cloning of NKCC2A Expressed in Dorsal Root Ganglia and its Heterologous Expression in Cell Lines 34. Michael Kent (Biochemistry and Molecular Biology) M.K. Makley, G.L. Jahns, N. DelRaso, D. Boverhof, L. Burgoon, D. Jump, T. Zacharewski and NV Reo TCDD Effects on Hepatic Metabolites - Mouse vs. Rat 35. Miryoung Lee (Community Health) Ramzi W. Nahhas, Audrey C. Choh, Ellen W. Demerath, Wm. Cameron Chumlea, Dana L. Duren, Richard J. Sherwood, Kimberly D. Williams, Bradford Towne, Roger M. Siervogel and Stefan A. Czerwinski Longitudinal Analysis of Calcaneal Quantitative Ultrasound Measures During Childhood 36. Oleg Paliy (Biochemistry and Molecular Biology) Harshavardhan Kenche, Frank Abernathy and Sonia Michail Community Microarray for Quantitative Analysis of Human Intestinal Microflora 37. Patricia Abboud (Pediatrics) Deena Kemper, Abigail Reidel and Adrienne Stolfi Established Protocols in Pediatric DKA Management Improve Morbidity 38. Patrick Sonner (Neuroscience, Cell Biology and Physiology) Maria C. Berrocal, Martyn Goulding and Francisco J. Alvarez Differences in Firing Properties Between V1-derived Renshaw and non-Renshaw Cells 39. Raminta Daniulaityte (Community Health) Robert Carlson, Russel Falck and Jichuan Wang Non-Medical Use of Pharmaceutical Opioids Among MDMA Users in Ohio 40. Rebecca Tuttle (Biochemistry and Molecular Biology and Surgery) Paual M. Termuhlen, Daniel Hood and Steven Berberich Epigenetic Downregulation of YPEL3 in Cancer Cell Lines and Human Colonic Adenocarcinoma 41. Richard Chou (Surgery) Drew M. Nedderman, Parviz H. Goshtasby, R. Michael Johnson and Andrea Hoffmann Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells (ADSCs) into Hematopoietic Lineages as Anti-Cancer Therapy for Melanoma 42. Richard Salisbury (Pharmacology and Toxicology) Eric J. Romer and Courtney E.W. Sulentic Role of NF-kappaB/Rel proteins in Mediating the Repressive Effects of TCDD on 3'alpha IgH RR Activation 43. Ruth Chambers-Turner (Pharmacology and Toxicology) Tharu Fernando and Courtney E.W. Sulentic Characterization of the Human IM-9 B-Cell Line; a Potential Model for Evaluating Chemical-Induced Modulation of the Human hs1,2 Enhancer 44. Ryan Finnan (Orthopaedic Surgery and Biological Sciences) Lynn A. Crosby, Christopher G. Anderson, Jon Gozdanovic and Mill W. Miller Tetracycline Labeling as a Measure of Humeral Head Viability after Three- and FourPart Proximal Humerus Fractures 45. Sapna Varia (Biological Sciences) Zhihui Deng, Alok Sharma, Athanasios Bubulya and Paula A. Bubulya Elucidating a Role of Btf in pre-mRNA Transcription and Splicing 46. Shannon Romer (Neuroscience, Cell Biology and Physiology) K. Dominguez, R. Fecher, Z. Deng, P. Nardelli, L. Goss, T.C. Cope and R.E.W. Fyffe Redistribution of Somatic Membrane Kv2.1 Ion Channels on Spinal Motoneurons Following Peripheral Nerve Injury 47. Shahong Mao (Pharmacology and Toxicology) F.J. Alvarez, M. Di Fulvio, K. Flues, T. Garzon-Muvdi, E. Delpire and F.J. Alvarez-Leefmans Changes in Intracellular Cl- Regulation in Primary Sensory Neurons During Postnatal Maturation are Independent of KCC2 Expression 48. Subbaraju Budharaju (Surgery) Curtis J. Wozniak, Rebecca J. Darner, Lawrence J. Prochaska, Scott A. Kerns, Shawn M. Gargac, Anthony J. Pothoulakis and Mark P. Anstadt Diastolic Augmentation During Direct Mechanical Ventricular Actuation 49. Tharu Fernando (Pharmacology and Toxicology) Roger Fecher and Courtney E.W. Sulentic TCDD-induced Modulation of the Human Polymorphic hs1,2 Enhancer within the 3'IgH Regulatory Region 50. Valerie Siembab (Neuroscience, Cell Biology and Physiology) D. S. Richards, M. C. Berrocal, M. Goulding and F. J. Alvarez Distinct Synaptic Development in 1a Inhibitory Interneurons Compared to Renshaw Cells 51. Zhongyu Yan (Pharmacology and Toxicology) William C. Grunwald Jr. and David R. Cool Chlorpyrifos Induces Inhibition of Insulin Signaling via DAG-lipase and Protein Kinase C Pathways 52. Ann Morrison (Psychiatry) B. Roman, N. Borges and J.M. Ballester Preliminary Results of a Study of Attitudes Towards Homeless Persons Among Medical Students During Psychiatry and Emergency Medicine Clerkships 53. Ann Morrison (Psychiatry) B. Roman Program Evaluation of the Psychiatric Experience of a Homeless Clinic 54. Brenda Roman (Psychiatry) Reza Khavari and David Hart Examining the Impact of a Chief Resident in Medical Student Education 55. David Hart (Psychiatry) A. Reza Khavari and Brenda Roman Combating Stigma: A Psychiatric Assessment Exercise at a State Psychiatric Hospital During 2nd Year Neuroscience 56. Donald Gronbeck (Emergency Medicine) Nathaniel Schlicher and Raymond Ten Eyck Critical Event Recall Following a Simulated Cardiac Arrest Resuscitation Does Not Differ at Two Weeks versus Six Weeks of Follow-Up 57. Erin McConnell (Internal Medicine and Pediatrics) Elvira Jaballas, Adrienne Stolfi, Carla Clasen and Dustin Anderson Community Service and the Pediatric Exam: An Introduction to Clinical Medicine via a Partnership Between First Year Medical Students and a Community Elementary School 58. Gary Nieder (Neuroscience, Cell Biology and Physiology) John C. Pearson, Nicole J. Borges and Dean X. Parmelee Characterization of High Level and Low Level Users of Online Lectures: Patterns of Use and Learning Styles 59. John C. Pearson (Neuroscience, Cell Biology and Physiology) Implementation of a Team-based Learning Module that Effectively Teaches Neurologic Localization Skills 60. Nathaniel Schlicher (Emergency Medicine) Raymond P. Ten Eyck and Melissa Schloneger Utilization of Simulation in Evaluation of Resuscitation Skills in Emergency Medicine and Internal Medicine Residents 61. Nathaniel Schlicher (Emergency Medicine) Thomas Proctor, Holly Long and Jessica Rutschilling Physician in Triage: An Experimental Approach for Improving Patient Care Times, Satisfaction, and Left Without Treatment Rates 62. Nathaniel Schlicher (Emergency Medicine) Raymond P. Ten Eyck Medical Malpractice: Identifying the Knowledge Gap 63. Nathaniel Schlicher (Emergency Medicine) Raymond P. Ten Eyck Medical Malpractice: Utilization of Layered Simulation for Resident Education 64. Nicole Borges (Community Health) R. Stephen Manuel and Carol L. Elam Millennial Medical School Students: Perspectives on Service 65. Raymond Ten Eyck (Emergency Medicine) Matthew Tews and John M. Ballester Improved Medical Student Satisfaction and Test Performance with a SimulationBased Emergency Medicine Curriculum: A Randomized Controlled Trial 66. Raymond Ten Eyck (Emergency Medicine) Matthew Tews and John M. Ballester Improved Medical Student Emergency Medicine Team Leader Skills Following a Simulation-Based Curriculum Office of Research Affairs