Helicase Wiki Research Project The speed at which molecular biology moves often makes certain aspects of textbooks obsolete within a few years. The aim of this project is to keep our course up to date with the latest findings in molecular biology and look at their impact on our understanding of the fundamental underpinnings of the central dogma: DNA to RNA to Protein. Rather than have you write a research paper that gets filed away in some filing cabinet, the result of this project will be a public document that anyone can access to get information on your topic. Future students in the class will read them and others may add new information to your work. Think of it as a dynamic textbook that you will be contributing chapters to. The second goal of the project is to encourage you to realize the potential of using web-based technologies so that you can design a truly interactive entry on our wiki. I want the topics to be driven by your interests not mine, so I will give you relatively free reign in determining your subject matter. The only constraint is that there has to be some connection to an aspect of the central dogma. Here are three broad topic areas you might consider: Human Disease Genes: This wiki page would have an in-depth description of the particular disease and it symptoms. It would then describe what gene, when mutated, causes the disease including what is know about its function how that may cause the disease. The only requirement here is that you must pick a disease about which a fair bit is known about the mutation that causes it. New Therapeutics: This wiki page would have an in depth description of particular medicines, how they work, and what diseases they are used for. This can include RNA interference, antibiotics, anti-virals, new chemotherapeutics, gene therapy approaches, and antibody based therapies New Lab Technologies: This wiki page would have an in depth description of cutting edge techniques in molecular biology, how they work, and how they have helped us understand some aspect of molecular biology. This could include new DNA sequencing technologies, new microarray based technologies, gene-chips for genotyping humans, gene-chips for tracking pathogens, single molecule microscopy, and the use fluorescent proteins. No matter which topic you choose, you must have 20 peer-reviewed references. We will have a discussion about peer-review issues and web-based resources on September 23rd. If you have an idea, but you are unsure if it is appropriate, just stop by and we can discuss it. Grading: I have attached the grading rubric that I will use to evaluate your wiki project. It outlines exactly what I am looking for and how many points will be assigned for each requirement. As you can see, I will be grading on content but also wiki design and interactivity. Since we are working in pairs, I ask that you divide the work equally between the two partners and indicate in your initial outline/wiki development plan which partner is responsible for particular parts of the wiki. Ultimately, as administrator of the wiki, I will be able to see who has added which sections of your page. You will have the opportunity to anonymously critique the contributions of your partner. This will be taken into account when I assign the final grade. Project Timeline and Due Dates (You will receive a 1 point deduction from your final grade for each day past the due date an assignment is turned in) Topic Approval: Topic must be approved by September 23rd Wiki Page Activated and Detailed Outline: Due on October 7th This must include a break down of each partner’s responsibilities Final Draft of Wiki Page: Due on November 4th Anonymous Peer-review: Due on November 11th Final Wiki Due: Due on November 25th The complete project is worth 125 points: 10 points assigned based on the final draft 5 points assigned based on usefulness of your peer-review 10 points assigned based on your contribution to project 100 points assigned as outlined in the grading rubric Note: It is possible for two partners to receive different grades based on their overall contribution to the project.