Curriculum Vitae
David E. Coleman
Last Update:12/18/09
CURRICULUM VITAE
David Emmett Coleman, Assistant Professor of Chemistry
Dec. 18, 2009
14615 Swale
San Antonio, TX 78248
Hm. ph.: (210) 479-2715
Off. ph.: (210) 829-3158
email: colemand@uiwtx.edu
Degrees
• Ph.D. - Biochemistry and Biophysics, 1989, University of North Carolina at Chapel Hill (UNC-CH),
Chapel Hill, NC
• B.S. - Chemistry, 1976, Emory University, Atlanta, GA
• A.A. - 1974, Oxford College of Emory University, Oxford, GA
Professional Experience
• Assistant Professor of Chemistry, University of the Incarnate Word (UIW), 2007 - present, San Antonio,
TX
• Chemistry Laboratory Coordinator, University of the Incarnate Word (UIW), 2004 - 2007, San Antonio, TX
• Assistant Professor (non-tenure track), Univ. of Texas Southwestern Medical Center (UTSW), 2001 - 2002,
Dallas, TX
• Instructor, UTSW, 1999 - 2001
• Research Associate, UTSW, 1994 - 1999
• Research Associate, Howard Hughes Medical Inst. (HHMI), 1990 - 1993, Dallas, TX
• Physical Education Instructor, UNC-CH, 1989, Chapel Hill, NC
• Post-doctoral research associate, UNC-CH, 1989
• Graduate research assistant, UNC-CH, 1978 - 1988
Courses Taught and Teaching Experience
Courses taught, UIW (overall, 2004 - 2009)
• Biological Chemistry I (CHEM 1310); Biological Chemistry II (CHEM 1320); Biological Chemistry II Lab
(CHEM 1320L); Chemical Principles II Lab (CHEM 1102); Biochemistry I (CHEM/BIOL 4351);
Biochemistry Lab (CHEM 4151); Independent Study/Protein Structure; Silk protein chemistry (CHEM
4398); Chemistry Research (CHEM 4260)
Courses taught, UTSW (overall, 1999 - 2002)
• Medical Biochemistry: (Course instructor/administrator for team-taught course for 200 medical students duties included assisting course coordinator and faculty, lecturing, editing and production of course text,
website publication of course text, development of exam questions, construction and maintenance of exam
question database, and exam administration (1999-2002))
• Protein X-ray Crystallography: (Course instructor / coordinator for team-taught graduate level course duties included course design, lecturing, editing and production of course materials, development of
computer exercises, and exam preparation and administration (2001)).
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Curriculum Vitae
David E. Coleman
Last Update:12/18/09
Other Teaching Experience
• Directed 16 undergraduate and high school student research projects as part of UIW Welch Program, UIW,
2004 - 2009
• Trained and supervised Work-Study students in chemistry laboratory techniques relevant to their duties
operating chemistry teaching labs, UIW, 2004 -2007
• Directed undergraduate research projects, UTSW, 1990-1995
• Taught physical education courses (martial arts), UNC-CH 1989
Scholarship
Publications, Abstracts, and Presentations
Davila, Elena, Lemley, Nickolas, Peigler, Rick, and Coleman, David "Chemical Analysis of Silk Fibroin
Proteins: A Set of Laboratory Exercises for Exploring Protein Science Suitable for Undergraduate Courses
in Biological and Organic Chemistry", (2010) Abstract accepted for the 113th Annual Meeting of the Texas
Academy of Science, Edinburg, TX, March 4-6, 2010.
Richter, Elizabeth, Campos, Jacob, Coleman, David, Gonzalez, Edward, and Chaudhuri, Alakananda Ray
"Inhibition of Malic Enzyme from Ascaris Suum", (2005) presented at the 108th Annual Meeting of the
Texas Academy of Science, Edinburg, TX, March 3-5, 2005.
Chavez, Felix, Sibley, Joseph, Coleman, David, Gonzalez, Edward, and Chaudhuri, Alakananda Ray
"Homology Model of Malic Enzyme of C. Elegans based on A. Suum Malic Enzyme", (2005) presented at the
108th Annual Meeting of the Texas Academy of Science, Edinburg, TX, March 3-5, 2005.
G.S. Jagannatha Rao, Coleman, D.E., Karsten, W.E., Cook, P.F. & Harris, B.G. (2003) "Crystallographic
Studies on Ascaris suum NAD-Malic Enzyme Bound to Reduced Cofactor and Identification of an Effector
Site", J. Biol. Chem. 278, 38051-38058.
Coleman, D.E., G.S. Jagannatha Rao, Goldsmith, E.J., Cook, P.F. & Harris, B.G. (2002) "Crystal Structure
of the Malic Enzyme from Ascaris suum Complexed with Nicotinamide Adenine Dinucleotide at 2.3 Å
Resolution", Biochemistry, 41, 6928-6938.
G.S. Jagannatha Rao, Coleman, D.E., Kulkarni, G.., Goldsmith, E.J., Cook, P.F. & Harris, B.G. (2000),
"NAD-Malic Enzyme from Ascaris suum: Sequence and Structural Studies", Protein and Peptide Letters, 7,
297-304.
Coleman, D.E. & Sprang, S.R. (1999), "Structure of Gi1•GppNHp: Autoinhibition in a G ProteinSubstrate Complex", J.Biol. Chem. 274, 16669.
Coleman, D.E. & Sprang, S.R. (1999), "Reaction Dynamics of G-protein Hydrolysis of GTP Viewed by
Crystallographic Snapshots of Gi1", Methods in Enzymology, (Enzyme Kinetics and Mechanism, Part E.),
308:70-92, V.L. Schramm & D.L. Purich, ed., Academic Press, San Diego.
Sprang, S.R. & Coleman, D.E. (1998), "Invasion of the Nucleotide Snatchers: Structural Insights into the
Mechanism of G Protein GEFs", Cell, 95, 155-159.
Coleman, D.E. & Sprang, S.R. (1998), "Crystal Structures of the G-protein Gi1 complexed with GDP and
Mg2+: A Crystallographic Titration Experiment", Biochemistry, 37, 14376-14385.
Raw, A, Coleman, D.E., Gilman, A.G. & Sprang, S.R. (1997), "Structural and Biochemical
characterization of the GTPS, GDP+Pi, and GDP bound forms of a GTPase deficient Gly42-Val Gi1
Mutant", Biochemistry, 36, 15660-15669.
Coleman, D.E. & Sprang, S.R. (1996), "How G Proteins Work: a continuing story." TIBS, 21, 41-44.
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Curriculum Vitae
David E. Coleman
Last Update:12/18/09
Wall, M.A., Coleman, D.E., Lee, E.L., Iñiguez-Lluhl, J.A., Posner, B.A., Gilman, A.G, & Sprang, S.R.
(1995), "The Structure of the G Protein Heterotrimer Gi112", Cell, 83, 1047-1058.
Mixon, M.B., Lee, E.L., Coleman, D.E., Berghuis, A.M., Gilman, A.G. & Sprang, S.R. (1995), "Tertiary
and Quaternary Structural Changes in Gi1 Induced by GTP Hydrolysis", Science, 270, 954-960.
Coleman, D.E., Berghuis, A.M., Lee, E.L., Linder, M.E., Gilman, A.G. & Sprang, S.R. (1994), "Structures
of Active Conformations of Gi1 and the Mechanism of GTP Hydrolysis", Science, 265, 1405-1412.
Coleman, D.E., Lee, E.L., Mixon, M.B., Linder, M.E., Berghuis, A.M., Gilman, A.G. & Sprang, S.R.
(1994), "Crystallization and Preliminary Crystallographic Studies of Gi1 and Mutants of Gi1 in the GTPand GDP-bound States" J. Mol. Biol., 238, 630-634.
Carter, C.W. Jr., Doublie, S. & Coleman, D.E. (1994), "Quantitative Analysis of Crystal Growth:
Tryptophanyl-tRNA Synthetase Crystal Polymorphism and its Relationship to Catalysis.", J. Mol. Biol., 238,
346-365.
Carter, C.W. Jr., Crumley, K., Coleman, D., Hage, F, 7 Bricogne, G. (1990), "Direct Phase Determination
for the Molecular Envelope of Tryptophanyl-tRNA Synthetase from Bacillus stearothermophilus by X-ray
Constrast Variation." Acta Crystallographica, A46, 57-68.
Carter, C.W. Jr. & Coleman, D.E. (1984) "Crystallization of Substrate and Product Analog Complexes of
Tryptophanyl-tRNA Synthetase from Bacillus stearothermophilus" Federation Proceedings, 43:15, 29812983.
Coleman, D.E. & Carter, C.W. Jr. (1984) "Crystals of Bacillus stearothermophilus Tryptophanyl tRNA
Synethetase Containing Enzymatically Formed Acyl Transfer Product TRP-ATP, an Active Site Marker for
the 3'(CCA) Terminus of TRP-tRNA" Biochemistry 23:381-384.
Educational Interests
• Integration of structural biology concepts into biology, biochemistry, and preprofessional courses
• Development of curriculum and testing materials for chemistry and biochemistry courses.
Scientific Interests
• Characterization of the structure and function of silk proteins
• Structure and function of Malic Enzyme
• Structure, mechanism and function of G-proteins
• Cellular signal transduction systems
• Structural biology - structure elucidation and analysis of biological molecules by the method of x-ray
crystallography
Service
UIW
• MSE United Way representative (2009)
• Moved and reconfigured CHEM 4151 and CHEM 1320L labs (2009)
• Participated and advised in PASS program for Biological Chemistry courses (1/2009 - present)
• Served on Biology Master's thesis committees, (two students, 2009)
• Faculty advisor for UIW Chemistry / Biochemistry majors (1/2009 - present)
• Served on Feik School of Pharmacy Faculty Hiring committee (1/2008 - present)
• Primary author of Biochemistry Degree Program for Chemistry Program, (in concert with Chem. faculty)
(2008)
• In concert with other Chem. faculty, assisted in developing Chemistry Program review (2008)
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Curriculum Vitae
David E. Coleman
Last Update:12/18/09
• In concert with other Chem. faculty (Dr. Julian Davis), and in consultation with Nursing School faculty,
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began major assessment and review of the chemistry sequence for pre-nursing students (CHEM
1310/1320/1320L), including redefinition and extension of course content and emphasis, and adoption of
new textbook (2008-2009)
Began redesign of the Biochemistry Laboratory including implementation of new experiments for Fall
2008-2009
In concert with Chem., Biol., and Nutrition faculty, modified prerequisites and catalog descriptions for the
upper level Biochemistry courses (CHEM / BIOL 4351, 4352, 4151L) (2008)
Assisted with new student advising during summer advising sessions (Summer, 2008)
Served on University Safety Committee (1/2007 - 8/2007) and continued to advise on development of
proposed University Chemical Hygiene Plan.
Chaired search committee for hiring new MSE Chemistry Laboratory Coordinator (Summer 2007)
Assisted in hiring adjunct chemistry faculty for Fall 2007 session
Professional Activities
• Attended Welch 52nd Conference on Chemical Research (Biological Macromolecules: from Structure to
Function) (Fall 2008)
Professional Affiliations
• Member, American Chemical Society, 2009
• Member, The Texas Academy of Sciences, 2009
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