University of Toronto
Cardiovascular Sciences Collaborative Program
ANNUAL REPORT
2001 – 2002
FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: cv.program@utoronto.ca
Web site: www.cscp.utoronto.ca
CONTENTS
DIRECTOR’S REPORT
MISSION STATEMENT
COLLABORATING DEPARTMENTS
COMMITTEES
- Executive
- Program
- Student
COURSES OFFERED
PROGRAM SPONSORED ACTIVITIES
- Annual Student Research Day
- Debate Night
- Human Biology Job Fair
- Summer Activities
AWARDS
- Medtronic Travel Award
- Bigelow Book Prize
- Lorne Phenix Graduate Award
- Ontario Student Opportunity Trust Funds (OSOTF) Award
- Life Sciences Committee Summer Undergraduate Research Fellowships
ADVERTISING MATERIAL
FUTURE DIRECTION
STUDENTS
- Currently Enrolled
- Convocated/Follow-Up
- Awards
FACULTY
- Members
- Awards and Honors
- Peer Reviewed Funding
PUBLICATIONS
- Students
- Faculty
ACKNOWLEDGEMENTS
DIRECTOR’S REPORT
The Cardiovascular Sciences Collaborative Program (CSCP) was officially established and
recognized by Governing Council of the University of Toronto in 1992 and underwent its 7-year
review in 1999 where it received a resounding endorsement from the Ontario Council of
Graduate Schools. Cardiovascular sciences has a rich and illustrious history at the University of
Toronto. Some achievements include contributions to the discovery of atrial natriuretic factor
(ANF), the first clinical use of heparin and more recently the use of gene therapy to treat heart
disease. Faculty were among the first to perform successful open heart surgery and implement
the use of hypothermia to protect hearts during surgery. In order to further encourage graduate
training in such a rich environment, the CSCP was created as an interdisciplinary graduate
training program which also crosses departments and Faculties, thus permitting cross-fertilization
of our student trainees. As each year passes I believe that the Cardiovascular Sciences
Collaborative Program becomes a more important link for the students. I am proud to present
this Annual Report which summarizes the achievements of the Program and its students and
faculty over the past academic year.
Students
In this academic year we had 26 Masters and 14 PhD trainees active in the Program (see graph
below). We also had a number of our trainees who completed and convocated. The PhD
category was counterbalanced by new recruits while at the MSc level enrolment exceeded the
convocated numbers. This is a reflection of initiatives focused in promoting more student
activities and available funding.
50
40
MSc
30
PhD
20
Total
10
0
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
The recently established Student Committee has strived to inform and guide trainees in the
Program. Specifically, their mandate is to (1) enhance trainee interaction through the
organization of both academic and social events and (2) to provide trainees with the tools to
make informed decisions about their graduate work in the form of mentoring and course
assessments. They continue to organize a very successful “Annual Student Research Day”, hold
various social functions, and launched their inaugural “Debate Night” that was well attended by
various faculty and students. It was a lively night and kudos to the students on such an exciting
event.
Our annual student interviews continue to show a high degree of satisfaction with the Program.
The increase in events targeted specifically for students resulted in more effective student
participation. The postgraduate follow-up illustrated that once again the students have gone on to
pursue either academic or research careers (see Convocated section). As part of our ongoing
tradition, bound copies of each graduating student’s thesis is kept in the Program office (total: 27
MSc and 13 PhD).
The student section of the web site is undergoing a revamping and we look forward to their
initiatives on the web. With such an enthusiastic and diverse group of students, it should be very
exciting to follow their initiatives in the upcoming year!
Events:
The Bigelow Book Prize is awarded to an outstanding Program student for sustained academic
excellence, innovative experimental approaches, original discoveries and good scientific
productivity. A plaque in Dr. Bigelow’s honour, mounted on the wall outside the Program
office, was unveiled and a reception held on October 1, 2001. All
the previous awardees and their supervisors were invited to attend
and be honoured with a miniature version of the plaque presented
to them by Dr. Bigelow. A number of distinguished guests and
faculty and students of the Program were invited to share in this
honour. Dean Naylor welcomed everyone on behalf of the
Faculty of Medicine and shared his pleasure in being able to
participate in the recognition of a man of such stature as Dr.
Wilfred G. Bigelow. Dr. Umberto de Boni, Associate Dean,
Division IV, brought greetings from the School of Graduate
Studies, then Dr. Ronald Baird, a personal friend and colleague of
Dr. Bigelow’s, gave an overview of the life of this famous
surgeon, scientist, and Canadian. It was clear to all who attended that Dr. Bigelow is a roll
model to all scientists and clinicians no matter what the specialty.
FR: Dr. Vivek Rao (1997), Dr. Saeid Babaei
(2001), Dr. Michael Borger (2000)
BR: Dr. Richard D. Weisel, Head, Division of
Cardiac Surgery, Dr. Ronald Baird, Dr.
Wilfred G. Bigelow, Dr. Catharine Whiteside,
Associate Dean, Inter-Faculty & Graduate
Affairs, Professor Umberto De Boni, Associate
Dean, Division IV – The Life Sciences, Dr.
Carin Wittnich, Director, CSCP, Dr. John
Ikonomidis (1995)
L-R: Dr. Ronald Baird, Dr. David Naylor, Dean of
Medicine, Dr. Richard D. Weisel, Head, Division of
Cardiac Surgery & Dr. Wilfred G. Bigelow
Education:
Due to their ongoing popularity, the MSC 3060/3061/3062/3063 courses have now been assigned
new joint listing designations “JCV” and approved by the School of Graduate Studies. Ongoing
and frequent review of these courses continues to ensure that leading edge technologies and
research foci are represented. This is considered critical if they are to continue to serve as our
flagship courses for our trainees. Enrolment continues to be strong in these courses and their
popularity is reflected in the strong reviews by the students.
The Program also has an established reputation in the area of Continuing Medical Education,
usually partnering with industry. This year, we hosted the first “Debate Night”, a venue to
discuss contentious issues relevant to both our students and faculty. We anticipate holding a few
of these throughout each academic year.
Financial:
Over the years the Collaborative Program has been very successful in raising an endowment as
well as funds for student travel, bursaries and other student related activity. For example, the
Medtronic Travel Award makes it possible for students to attend scientific meetings and present
their work and the OSOTF bursary provides much needed financial relief to deserving students.
These funds are available on an annual basis to help those with demonstrated academic and
research excellence that are in financial need. Major corporate sponsors such as Merck Frosst
Canada & Co., and Solvay Pharma, are to be recognised, once again, for their outstanding annual
support of education in the cardiovascular sciences at the University of Toronto.
Despite these successes, it is clear that to ensure the Program’s long-term stability, stable
infrastructure for the day-to-day operations is absolutely critical and to that end, the Dean of the
Faculty of Medicine recommended the creation of a task force to review and make
recommendations on its future. This task force consisted of representatives familiar with the
Program but not necessarily intimately involved to ensure an unbiased review of its past activities
and future direction. I am pleased to report that the task force resoundingly endorsed the
Program and clearly identified and agreed with its value-added for the graduate students
interested in the field of cardiovascular sciences. It is heartwarming to realize that the
Cardiovascular Sciences Collaborative Program is highly regarded across the campus. Its
interdisciplinary nature and the fact that faculty and student research crosses the pillars of the
CIHR as well as the departments across the Faculty of Medicine makes this a truly model
program at the University of Toronto. All agreed that it did need to have a stable infrastructure
support to permit it to continue to develop and grow and a number of suggestions and initiatives
were proposed. In order to position the Program to be as successful as possible in this venture it
would be important for the participating groups to provide some financial support. This would
serve to indicate to potential donors that this is an extremely important initiative at the
University. Over the upcoming academic year, we will be addressing the Programs infrastructure
stability.
Summary:
As you continue to read through this report, you will see that it has undergone some modification
and a change in its look to reflect the tremendous growth that has occurred. I would like to thank
Miss Victoria Simpson, our Business Officer, for her hard work and contribution that has made
the Cardiovascular Sciences Collaborative Program the success it is today.
Finally, I would like to take this opportunity to thank all our faculty and students for another
successful year and to those individuals who have continued to provide both moral and tangible
support for this Program.
Dr. Carin Wittnich, O.Ont.
Director, CSCP
Professor of Surgery & Physiology
Northrop Frye Scholar
MISSION STATEMENT
“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario
Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate
Studies, exists to give formal, organized expression to cardiovascular studies and research at the
graduate level. It builds on the strengths of all participating academic units, and other agencies,
to enhance the visibility of cardiovascular studies and to facilitate collaborative,
interdisciplinary training and research.”
The above mission is achieved by advertising and promoting the importance of, and
opportunities in, cardiovascular studies, by making known the results of such studies, by
recruitment of excellent students, and by coordinating the graduate collaborative program in
cooperation with the academic units in which they are registered. Students in this collaborative
program must fulfill the requirements of their home units as well as the Program. Upon
graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s
academic transcript and the Program will present the student with a certificate and gift.
COLLABORATING FACULTIES
Medicine
Physical Education and Health
COLLABORATING GRADUATE UNITS
Department of Exercise Sciences
Department of Laboratory Medicine and Pathobiology
Department of Medical Biophysics
Department of Pharmacology
Department of Physiology
Department of Public Health Sciences
Department of Rehabilitation Science
Institute of Biomaterials and Biomedical Engineering
Institute of Medical Science
SUPPORTING CLINICAL DEPARTMENTS
Department of Anaesthesia
Department of Medicine
Department of Surgery
COMMITTEES
Executive
The Executive Committee consists of 4 members of the Program Committee representing as
wide a range of disciplines as possible and includes the Director. The Executive Committee
provides student counselling, screens applicants, provides advice and acts as a Steering
Committee.
Dr. C. Wittnich (Chair)
Dr. M. Rand (Laboratory Medicine & Pathobiology)
Dr. S. Thomas (Exercise Sciences)
Dr. R. Weisel (Institute of Medical Science)
Program
The Program Committee consists of a representative from each collaborating department as well
as two student representatives. It administers the Program, selects the Director, and generally
meets twice per year.
Dr. C. Wittnich (Chair)
Dr. L. Adamson (Physiology)
Dr. D. Brooks (Rehabilitation Science)
Dr. D. Mazer (Anaesthesia)
Dr. R.I. Ogilvie (Pharmacology)
Dr. M. Ojha (Institute of Biomaterials and Biomedical Engineering)
Dr. M. Rand (Laboratory Medicine and Pathobiology)
Dr. S. Thomas (Exercise Sciences)
Dr. R.D. Weisel (Institute of Medical Science)
Dr. G. Wright (Medical Biophysics)
Nathalie Lapointe (Sr. Student Representative)
Renee Suen (Jr. Student Representative)
Student
The Student Committee was set up by the students and consists of the two student representatives
from the Program Committee (who act as Co-Chairs) and 2 student members. They meet and
oversee all student activities of the Program.
Ms. Nathalie Lapointe (Chair)
Ms. Renee Suen (Co-Chair)
Ms. Nesime Askin (Member)
Ms. Sonja Reichert (Member)
COURSES OFFERED
BME1448H Cardiovascular Fluid Mechanics (BME)
EXS5508H Cardiovascular Disease and Exercise (EXS)
JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal
Transduction (IMS/PSL)
JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular
System (IMS/PSL)
JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function (IMS/PSL)
JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular (IMS/PSL)
JEB1365H
Ultrasound: Theory and Applications in Biology and Medicine (BME)
JTC1331H
Biomaterials Science (BME)
LMP1015H Vascular Pathobiology (LMP)
LMP1504H Biochemistry, Molecular Biology of Cardiovascular Diseases (LMP)
PSL1038H
Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments
(PSL)
PSL1060H
Developmental Cardiovascular Physiology (PSL)
PSL1462H
Molecular Aspects of Cardiac Function (PSL)
* Core Courses for PhD Trainees
Suggested Courses (Considered valuable but does not fulfill Program requirements)
CHL5201
LMP1404S
PSL1052H
Introducing Biostatistics for Students in Biological Sciences (CHL)
Cellular and Molecular Mechanisms of Disease (LMP)
Fundamentals on Ion Channel Function (PSL)
PROGRAM SPONSORED ACTIVITIES
Annual Student Research Day
On Wednesday, February 27, 2002, the Cardiovascular Sciences Collaborative Program held its
3rd Annual Student Research Day in the Medical Sciences Bldg. This was a fun filled day that
was attended by CSCP trainees and faculty. Trainees began the day by giving a ten minute talk
related to their research, followed by a question/answer period as below.
SESSION I: Chair – Renee Suen
Asim Cheema (PhD – Institute of Medical Science)
“Adenoviral Mediated Decorin Overexpression Inhibits Intimal Hyperplasia in a Rabbit
Angioplasty Model”
Roland Leung (MSc – Institute of Medical Science)
“Persistence of Procoagulant Surface Expression by Activated Platelets”
Carol Kolb (MSc – Physiology)
“Effects of Gestational Age and Ultrasound Frequency on the Echogenicity of Structures in the
Developing Mouse Embryo”
Shathiyah Kulandavelu (MSc – Physiology)
“Maternal Cardiovascular Changes During Pregnancy in eNOS Knockout Mice”
Sonja Reichert (MSc – Exercise Sciences)
“Effects of Combined Resistance and Aerobic Training on Muscular Strength, Blood Flow and
Aerobic Power in Patients with Coronary Artery Disease”
Paul Fedak (PhD – Institute of Medical Science)
“Unraveling Aortic Dilatation in Patients with Congenital Aortic Valve Malformations: A Novel
Mechanism”
SESSION II: Chair – Sonja Reichert
Renee Suen (MSc – Institute of Medical Science)
“Role of Endothelin-1 in Accelerated Atherosclerosis and Aortic Aneurysm Formation”
Li Yang (PhD – Laboratory Medicine and Pathobiology)
“Conditional Cardiac Endothelin-1 Over Expression in Transgenic Mice Causes Myocardial
Hypertrophy and Inflammation”
Jennifer Sarjeant (MSc – Institute of Medical Science)
“The Role of Apolipoprotein D in Vascular Smooth Muscle Cell Proliferation”
Anjum Khan (MSc – Institute of Medical Science)
“Atrial Remodeling in Congestive Heart Failure”
Neelesh Jain (MSc – Institute of Medical Science)
“The Role of NF-kB in Human Atherosclerosis”
Nataly Kogan (MSc – Physiology)
“Substance P in the Cardiovascular Actions of ‘New Pressor Protein’ (NPP)”
Sandra Merklinger (MSc – Institute of Medical Science)
“MMP Inhibition and b3 Blockade Induce the Regression of Pulmonary Vascular Disease in
Organ Culture”
In the afternoon trainees were given valuable advice from Drs. Gary Webb and Bill Williams
who also shared with the students how they began their research/clinical careers. This session
was followed by a discussion period in which students had an opportunity to discuss the trials
and tribulations of living a life devoted to education and research with these highly respected and
successful clinicians. The day concluded with a wine and cheese reception where students and
faculty mixed and mingled, after which most of the students continued their interactions at a
student planned social event.
The Student Research Day met with resounding success. This day would not have been possible
without the efforts of the Planning Committee: Nesime Askin (Chair), Sonja Reichert and Renee
Suen (Co-Chairs) and Nathalie Lapointe (Member). Congratulations on a job well done!
Debate Night
The Student Committee organized this exciting event for the cardiovascular community at the
University of Toronto. The goal of this event was to provide graduate students with the chance
to learn and form their own opinions in delicate subject matters that challenge the scientific
community and to provide an opportunity for the faculty to voice their point-of-view. The topic
of the inaugural debate was “Be It Resolved that the Impact Factors is an Important Determinant
of Success in Research”. The debate was moderated by Dr. Peter Liu, who introduced the
protagonist, Dr. Jean Rouleau, and the antagonist, Dr. Dan Osmond. Both debaters passionately
made their case. Despite their eloquence the vote was split fairly even, certainly showing the
controversy that this issue raises and the fixed views held by those in attendance. With the
success of this event, we look forward to organizing future debates.
Lecture Series
For this academic year the lecture series was focused in the two main areas of “Molecular
Biology & Heart Signal Transduction” and “Hormones in the Cardiovascular System”. A
number of interesting speakers contributed their time and knowledge. Both these areas were
covered from the perspective of whole body and organ to the molecular level including genetics,
with a particular emphasis on bridging basic science and clinical approaches to these areas.
Human Biology Student Union Career Fair
The Cardiovascular Sciences Collaborative Program participated in the Human Biology
Undergraduate Student Association Career Fair on November 15, 2001. Various graduate
programs had displays and students in the Collaborative Program manned a table and provided
information to interested future graduate students.
Summer Seminar Series
The Collaborative Program ran another very successful summer program. Applicants included
undergraduate and medical school students from the University of Toronto as well as other
universities. The Program provided a number of summer scholarships to help students who were
unable to procure funding. Over the course of the summer, seminars were presented by graduate
students currently enrolled in the Program and covered a range of topics with both clinical and
basic science relevance (see below). The purpose of the seminar series is to provide a common
and relaxed forum for presentation of timely topics and a review of basic science. As well, the
summer students were given the opportunity to present their summer work. An “end-ofsummer” luncheon was held for both faculty and students. This highly successful program is
enjoyed by all who participate.
May 31st
June 7th
June 14th
June 21st
June 28th
July 5th
July 12th
July 19th
July 26th
August 2nd
August 9th
August 16th
Dr. Carin Wittnich
“Introduction & Video: William Harvey and the Circulation of Blood”
Asim Cheema (Institute of Medical Science – PhD)
“Arterial Repair After Balloon Angioplasty”
Sandra Merklinger (Institute of Medical Science – MSc)
“Matrix Metalloproteinase, Alpha vs. Beta 3 and EGF Receptor Blockade Induce
the Regression of Pulmonary Vascular Disease”
Roland Leung (Institute of Medical Science – MSc)
“Platelets and Their Role in Hemostasis and Thrombosis”
Carol Kolb (Department of Physiology – MSc)
“Effects of Gestational Age and Ultrasound Frequency on the Echogenicity of
Structures in the Developing Mouse Embryo”
Rohan Dharmakumar (Medical Biophysics – PhD)
“Magetic Resonance Imaging Based Intro-Cardiac and Intravascular Pressure
Measurement”
Summer Student Presentations – Project Introductions
Golnaz Karoubi (Biomedical Engineering – MSc)
“Single Cell Gene Expression for Optimization of Cell Therapy”
Shawn Brady (Rehabilitation Science – MSc)
“Predicting Participation in Cardiac Rehabilitation After Coronary Artery
Bypass Surgery”
Mona Shawky (Institute of Medical Science – MSc)
“Chlamydia Pneumonia and Atherosclerosis”
John Esposito (Rehabilitation Science – MSc)
“The Effects of Recombinant Human Growth Hormone on Physical Function in
Patients with HIV Wasting”
I. Eser Adiguzel (Laboratory Medicine & Pathobiology – MSc)
“Type VIII Collagen Functions in Vascular Disease”
Summer Student Presentations – Project Results
AWARDS
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This award,
established in 1995, helps to defray costs of travel for Program students presenting their research
work at recognized scientific meetings. Students supported by this award this academic year
were:
Fall 2001:
Sheila Riazi, MSc, Institute of Medical Science: “The Role of Elastin and Elastin Receptor
Subunit in Modulation of Cellular Proliferation.” Canadian Cardiovascular Congress 2001
(Supervisor: Dr. A. Hinek)
Karim Bandal, PhD, Physiology: “Could High Oxygen Levels (Hyperoxia) in Newborns Alter
Glucose Metabolism and Decrease Heart Function?” Canadian Cardiovascular Congress 2001
(Supervisor: Dr. C. Wittnich)
Jack Wallen, PhD, Physiology: “Does the Presence of LV Hypertrophy Alter Expression of
Estrogen Receptor Isoforms?” Canadian Cardiovascular Congress 2001 (Supervisor: Dr. C.
Wittnich)
Spring 2002:
Renee Suen, MSc, Institute of Medical Science: “Role of Endothelin-1 (ET-1) in Accelerated
Atherosclerosis and Aortic Aneurysm Formation in Response to Angiotensin II (AII).”
Experimental Biology 2002 (Supervisor: Dr. D. Stewart)
Nataly Kogan, MSc, Physiology: “Cardiovascular Actions of ‘New Pressor Protein’ (NPP,
Related to Coagulation -FXIIa) are Influenced by Both ACE and NEP Inhibition” and
“Cardiovascular Effects of Coagulation FXIIa – Related ‘New Pressor Protein’ (NPP) are
Mediated by a Non-Cholinergic Mechanism”, International Society of Hypertension and
European Society of Hypertension (joint meetings). (Supervisor: Dr. D. Osmond)
Akis Amfilochiadis, MSc, Physiology: “Dose-Dependant Effects of ACE-Inhibition on the
Cardiovascular Actions of Human FXIIa-Related ‘New Pressor Protein’ (NPP)”, International
Society of Hypertension and European Society of Hypertension (joint meetings). (Supervisor: Dr.
D. Osmond)
Bigelow Book Prize
The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts”
and “Mysterious Heparin” and a miniature version keeper plaque created to honor Dr. Bigelow.
This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to
recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences.
Awardees should exemplify the personal traits of Dr. Bigelow -- curiosity, drive, and scientific
integrity. The award is given in every year that a qualified student is identified. Qualifications
include sustained academic scientific excellence, innovative experimental approaches, original
discoveries and good scientific productivity. Some weight is given to work that has recognizable
clinical relevance, especially that which promises to improve patient care. Appropriate
candidates were identified and the final decision was made by the Program Committee.
1995 – Dr. John S. Ikonomidis
1996 – Ms. Shona M. Torrance
1997 – Dr. Vivek Rao
1998 – Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
2000 – Dr. Michael Borger
2001 – Dr. Saeid Babaei
2002 – Mr. Wm. Jack Wallen
Lorne Phenix Graduate Award
This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by
Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart
disease – which is still the #1 killer of both men and women in Canada. In addition, women who
have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that
this award will serve to encourage trainees to pursue this area of research to address this
particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of
research and academic excellence. The award consists of a cash prize and certificate and is
presented to the recipient at the Annual Student Research Day. Appropriate candidates are
identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart.
2001 – Wm. Jack Wallen
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards that have resulted from the Ontario government’s
“matching” program. Under the program every dollar of donation received for student assistance
has been matched by the government as well as the university on a dollar-for-dollar basis. The
Cardiovascular Sciences Collaborative Program participates in this program. There are two
major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate
financial need. However, the Program has additional eligibility criteria that must be adhered to,
including excellence in science and academic performance. One competition is held per
academic year.
The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty
and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then
adjudicated by a subcommittee; this year chaired by Professor M. Ojha. Committee
recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine)
where the final decision is made. This competition, normally held in the Spring, was deferred to
the fall of 2002 to capture all needy candidates.
Life Sciences Committee Summer Undergraduate Research Fellowships
These fellowships are awarded to support research at the University of Toronto to assist
undergraduate students seeking training for graduate level research. Funds were awarded to the
Cardiovascular Sciences Collaborative Program for 8 undergraduate trainees. All candidates put
forward by the Program were awarded funding.
Emily Chan – Supervisor: Dr. Stephen Fremes
Michael Charnish – Supervisor: Dr. Greg Wilson
Sarah Munce – Supervisor: Dr. Donna Stewart
Avi Orner – Supervisor: Dr. Vivek Rao
Bheeshma Ravi – Supervisor: Dr. Mansoor Husain
David Santone – Supervisor: Dr. Tom Lindsay
N. Raj Satkunasivam – Supervisor: Dr. John Coles
Nazneen Tata – Supervisor: Dr. Michael Sole
ADVERTISING MATERIAL
The Cardiovascular Sciences Collaborative Program maintains and updates its web site
(www.cscp.utoronto.ca) on a regular basis. Faculty information is updated whenever we are
notified of relevant changes. This year Victoria Simpson revamped the entire website look to
optimize efficient use by visitors. The Program students took an active part in creating their own
sections, including short bios on each student, course summaries/surveys to help other students
pick courses suitable for their needs, and are working on a bulletin board section to keep
everyone updated on cardiovascular activities. Collaborating departments are encouraged to
provide hypertext links to the Collaborative Program on their web site.
The Program distributes brochures at the various campus activities and the collaborating
departments are encouraged to have links with the CSCP’s web site and distribute brochures.
FUTURE DIRECTION
For the 2002-2003 academic year, we plan to continue our current activities and pursue the
following priorities:








Continue developing endowments to provide permanent infrastructure support.
Firm up a 5-year plan for the program.
Create a Cardiovascular Resource Centre
Target recruitment of PhD students.
Recruit clinical residents doing 1-2 years of research into a formal graduate program
where appropriate.
Graduate training grant application (CIHR)
Further develop the student section in the Program’s web site.
Further develop CME programs in cardiovascular sciences.
STUDENTS
Currently Enrolled
Student
I. Eser Adiguzel
Akis Amfilochiadis
Nesime Askin
Karim Bandali
Shawn Brady
Andrew Campbell
Asim Cheema
Rohan Dharmakumar
John Esposito
Paul Fedak
Warren Foltz
Tommaso Gori
Neelesh Jain
Golnaz Karoubi
Anjum Khan
Nataly Kogan
Carol Kolb
Shathiyah Kulandavelu
Nathalie Lapointe
Roland Leung
Negin Liaghati-Nasseri
Sarah McCutcheon
Sandra Merklinger
Vaska Micevski
Peter Papageorgiou
Ali Pourdjabbar
Sonja Reichert
Clea Senechal
Mona Shawky
Renee Suen
Shona Torrance
Jack Wallen
Li Yang
Supervisor
M. Bendeck
D. Osmond
C. Wittnich
C. Wittnich
S. Thomas/D. Brooks
D. Stewart
B. Strauss
G. Wright
S. Thomas
R. Weisel
G. Wright
J. Parker
K.W. Johnston
D. Courtman
B. Strauss
D. Osmond
L. Adamson
L. Adamson
J. Rouleau
M. Rand
S. Fremes
S. Thomas
M. Rabinovitch
D. Stewart
D. Osmond
J. Rouleau
J. Goodman
P. Liu
P. Liu
D. Stewart
C. Wittnich
C. Wittnich
D. Stewart
Degree
MSc
MSc
MSc
PhD
MSc
PhD
PhD
PhD
MSc
PhD
PhD
MSc
MSc
MSc
MSc
MSc
MSc
PhD
PhD
MSc
MSc
MSc
MSc
PhD
MSc
MSc
MSc
MSc
MSc
MSc
PhD
PhD
PhD
Department
LMP
PSL
PSL
PSL
REH
IMS (inactive status)
IMS
MBP
REH
IMS
MBP
IMS
IMS
BME
IMS
PSL
PSL
PSL
IMS
IMS
IMS (inactive status)
REH
IMS
IMS
PSL
IMS
EXS
IMS
IMS
IMS
IMS (inactive status)
PSL
LMP
Convocated Students/Follow-Up
Zakaria Ahmed, PhD, Laboratory Medicine & Pathobiology (Supervisor: Dr. P. Connelly)
“Characterization of Phosphatidylcholine Oxidation Products Obtained by Exposure of High
Density Lipoprotein to Peroxynitrite Donor, SIN-1”
Is working as a Post-Doctoral Fellow in Clinical Chemistry at the University of Louisville.
Saeid Babaei, PhD, Laboratory Medicine & Pathobiology (Supervisor: Dr. D. Stewart)
“Role of Nitric Oxide in Angiogenesis”
Is working as a Research Associate with Dr. Duncan Stewart.
Sloane Hechter, MSc, Institute of Medical Science (Supervisor, Dr. P. Liu)
“Factors that Limit Exercise Performance and the Use of Angiotensin Converting Enzyme
Inhibitors in Adult Survivors of the Mustard Procedure”
Has been accepted into medical school at McMaster University.
Nikolaos Mamalias, MSc, Institute of Medical Science (Supervisor, Dr. P. Dorian)
“Effect of Combination Potassium Channel Blockers on Cardiac Refractoriness in Isolated
Rabbit Hearts and Intact Guinea Pig Hearts”
Has been accepted into medical school at the University of Toronto.
Sheila Riazi, MSc, Institute of Medical Science (Supervisor, Dr. A. Hinek)
“Pathophysiological Links Between Impaired Elastogenesis and Increased Cellular
Proliferation in Development of Cardiovascular Disorders”
Plans on obtaining her medical license and getting more involved in cardiovascular research.
Jennifer Sarjeant, MSc, Institute of Medical Science (Supervisor, Dr. M. Rabinovitch)
“The Role of Apolipoprotein D in Vascular Smooth Muscle Cell Proliferation”
Returning to cardiac surgery residency.
Damir Simic, MSc, Laboratory Medicine & Pathobiology (Supervisor, Dr. A. Hinek)
“Disclosure of Novel Mechanisms in Which Nicotine Triggers Structural and Functional
Alterations of Arterial Smooth Muscle Cells – Implications to Pathogenesis of the Occlusive
Arterial Diseases”
Plans to work in a laboratory setting with a biotech company.
Awards
Zakaria Ahmed
Akis Amfilochiadis
Nesime Askin
Karim Bandali
University of Toronto Fellowship
American Association of Clinical Chemists, Graduate Student Travel
Award, Chicago
University of Toronto Bursary Award
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Heart & Stroke/Richard Lewar Centre of Excellence Fellowship
OERS Volunteer of the Year Award 2001
National Science and Engineering Research Council (NSERC-PGSB)
Scholarship
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Richard Rowe Prize for Excellence in Research, Pediatric Cardiology
Ontario Student Opportunity Trust Fund (OSOTF) Award, Cardiovascular
Sciences Collaborative Program
Department of Physiology, Doctoral Scholarship
Shawn Brady
Asim Cheema
John Esposito
Paul Fedak
Tommaso Gori
Nataly Kogan
S. Kulandavelu
Nathalie Lapointe
Roland Leung
Sarah McCutcheon
Sandra Merklinger
Vaska Micevski
Peter Papageorgiou
Ali Pourdjabbar
Sonja Reichert
Sheila Riazi
Ontario Graduate Scholarship in Science and Technology (OGSST)
Ruth Bradshaw Award
Toronto Rehabilitation Institute Student Award
Heart & Stroke/Richard Lewar Centre of Excellence Fellowship
Connaught Scholarship, Department of Rehabilitation Science
C. Walton Lillehei Research Award Finalist, American Association for
Thoracic Surgery
Trainee Travel Award, American Society of Clinical Investigation and
American Association of Physicians (joint meeting)
Research Fellowship, Heart & Stroke Foundation of Canada
E. McGloin Fellowship for highest rated trainee in Ontario, Heart &
Stroke Foundation of Ontario
Borsa di Ricerca Progetto Giovani Ricercatori, University of Siena
Young Investigator Award, First Place, American College of Cardiology
S.A. Levine’s Young Investigator Award, First Place, American Heart
Association
Ontario Graduate Scholarship in Science and Technology (OGSST), Heart
& Stroke Foundation of Ontario
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Heart & Stroke/Richard Lewar Centre of Excellence Fellowship
Young Investigator’s Award, 13th World Congress International Society
FRSQ (Fonds de la recherche en sante du Quebec) Fellowship
John D. Schultz Science Student Scholarship, Heart & Stroke Foundation
of Ontario
St. Michael’s Hospital Summer Student Scholarship
University of Toronto Open Scholarship
CIHR Burroughs Wellcome Student Award
Ontario Graduate Scholarship in Science and Technology (OGSST), Heart
& Stroke Foundation of Ontario
Studentship Appointment, Research Training Centre, Hospital for Sick
Children
Heart & Stroke Foundation Merit Award, 1st Prize, Nursing
HCFO Research Award Scholarship
AHEPA Scholarship
New England Hellenic Medical & Dental Society Research Award,
Harvard University
University of Toronto Open Scholarship
Ontario Graduate Scholarship in Science and Technology (OGSST), Dr.
Arnie Aberman Award
University of Toronto Fellowship
Terry Kavanagh Award, University of Toronto
Thera-Band® Resistive Band Support Award, The Hygenic Corporation
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Restracomp, Hospital for Sick Children Research Institute Award
Jennifer Sarjeant
Clea Senechal
Mona Shawky
Renee Suen
Jack Wallen
Liz Yang
Research Training Centre Postdoctoral Fellowship, Hospital for Sick
Children
Miriam Neveren Memorial Award, Faculty of Medicine
Elizabeth Arbuthnot Dyson Fellowship, Faculty of Medicine
Research Fellowship, Heart & Stroke Foundation of Canada
University of Toronto Open Fellowship
Ontario Graduate Scholarship in Science and Technology (OGSST)
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Heart & Stroke/Richard Lewar Centre of Excellence Fellowship
Medical Research Council/K.M. Hunter Doctoral Research Award
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Lorne Phenix Graduate Student Award 2001, Cardiovascular Sciences
Collaborative Program
Student Presentation Award, 1st Prize, Canadian Cardiovascular Society
Doctoral Research Award, Heart & Stroke Foundation of Canada
FACULTY
Members
Faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS
status. Details on faculty research interests and contact information are available on the web site.
Departmental affiliations listed are those within the CSCP.
Full
Name
Departmental Affiliation(s)
Location
Lee Adamson
Khosrow Adeli
Peter Backx
Michelle Bendeck
Douglas Bradley
John Coles
Philip Connelly
C. Ross Ethier
John S. Floras
Christopher Forrest
Stephen Fremes
Jack M. Goodman
Avrum I. Gotlieb
Aleksander Hinek
K. Wayne Johnston
Peter G. Kalman
Fred Keeley
B. Lowell Langille
Gary F. Lewis
Ren-Ke Li
C-C. Liew
BME/IMS/PSL
LMP
IMS/Medicine/PSL
LMP/Medicine
IMS/Medicine
IMS/Surgery
LMP/Medicine
BME
IMS/Medicine
IMS/Surgery
IMS/Surgery
EXS
LMP
IMS/LMP
BME/IMS/Surgery
IMS/Surgery
LMP
LMP
IMS/Medicine
IMS/LMP/Surgery
IMS/LMP/Medicine
Mount Sinai Hospital
Hospital for Sick Children
UofT - HSRLCE
UofT - MSB
Toronto General Hospital
Hospital for Sick Children
St. Michael’s Hospital
UofT – Mechanical Engineering
Mount Sinai Hospital
Hospital for Sick Children
SWCHSC - Sunnybrook
UofT - Physical Ed & Health
Toronto General Hospital
Hospital for Sick Children
Toronto General Hospital
Community
Hospital for Sick Children
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
UofT – Banting Institute
Peter Liu
Marius Locke
Peter McLaughlin
Donald A.G. Mickle
Lynda Mickleborough
David Naylor
Matadial Ojha
Tom Parker
Margaret Rand
Jean L. Rouleau
Michael Sefton
Arthur S. Slutsky
Michael J. Sole
Donna E. Stewart
Duncan Stewart
Bradley Strauss
Scott G. Thomas
Richard D. Weisel
Gregory Wilson
Carin Wittnich
Graham Wright
IMS/Medicine
EXS/Public Health
IMS/Medicine
LMP/Surgery
IMS/Surgery
IMS/Medicine/Public Health/Surgery
BME/Surgery
IMS/Medicine
IMS/LMP
IMS/Medicine
BME
IMS/Medicine/Surgery
IMS/Medicine/PSL
Anesthesia/IMS/Surgery/Medicine
IMS/LMP/Medicine
LMP/Medicine
EXS/PSL
IMS/Surgery
IMS/LMP/PSL/Surgery
IMS/PSL/Surgery
MBP
Toronto General Hospital
UofT – Physical Ed & Health
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
UofT - MSB
UofT – Rosebrugh Bldg.
Toronto General Hospital
Hospital for Sick Children
Toronto General Hospital
UofT – Wallberg Bldg.
Mount Sinai Hospital
Toronto General Hospital
Toronto General Hospital
St. Michael’s Hospital
St. Michael’s Hospital
UofT – Physical Ed & Health
Toronto General Hospital
Toronto General Hospital
UofT - MSB
SWCHSC - Sunnybrook
Tai-Wing Wu
Erik L. Yeo
LMP
IMS/Medicine
Toronto General Hospital
Toronto General Hospital
REH
BME/Surgery
IMS/Medicine/PCL
EXS
IMS/LMP/Medicine
Public Health
IMS/Surgery
IMS/Medicine
LMP
IMS/Medicine/PSL
IMS/Medicine
IMS
UofT – Rehabilitation Science
St. Michael’s Hospital
St. Michael’s Hospital
Def & Civil Inst Environ Med
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
Mount Sinai Hospital
Community
UofT - MSB
Mount Sinai Hospital
Hospital for Sick Children
LMP/Medicine
Surgery
Anaesthesia
Anesthesia
Anaesthesia
Medicine/PCL
Medicine
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
St. Michael’s Hospital
Toronto General Hospital
Toronto Western Hospital
Toronto General Hospital
IMS/Medicine/PSL/Surgery
UofT – MSB
Associate
Dina Brooks
David Courtman
Paul Dorian
Len S. Goodman
Mansoor Husain
Jane Irvine
Tom Lindsay
John Parker
Nisar A. Shaikh
Robert Tsushima
Robert Wald
Lori West
Affiliate
Jagdish Butany
Chris M. Feindel
Joel Fisher
David Mazer
Patricia Murphy
Richard I. Ogilvie
Len Schwartz
Retired
Colin E. Bayliss
Flavio Coceani
Daniel H. Osmond
George Steiner
PSL
IMS/Medicine/PSL
IMS/Medicine/PSL
Hospital for Sick Children
UofT – MSB
Toronto General Hospital
New Positions
We would like to wish the following faculty all the best in their new positions:
Davy Cheng, University of Western Ontario
Michael Plyley, Brock University
Marlene Rabinovitch, Stanford University
Awards and Honors
Khosrow Adeli
Simon-Pierre Noel Lectureship Award, Canadian Lipoprotein Award,
presented in October 2001, Digby, Nova Scotia
Paul Dorian
Critical Care Best Abstract Award, AHA Annual Meeting, 2001
C. Ross Ethier
Tier I Canada Research Chair in Computational Technology
Joseph A. Fisher
3rd Prize: Outstanding Scientific and Educational Exhibit, American
Society of Anesthesiologists Annual Meeting, 2001. “2 ways to save O2;
3 ways to isocapnia”
John Floras
Lloyd S.D. Fogler Q.C. Award for Research Excellence (Mount Sinai
Hospital)
President, Canadian Hypertension Society
Mansoor Husain
Clinician-Scientist Award, Phase II. CIHR, 2001-2004
Avrum I. Gotlieb
Award of Merit, 2001, Society for Cardiovascular Pathology, Inc.
Ren-Ke Li
Premier’s Research Excellence Award, Ontario Ministry of Energy,
Science and Technology, 2001
Thomas Lindsay
Wightman-Berris Academy – Award for Individual Teaching
David Naylor
Keynote Lecture, OECD Symposium on Measuring Health System
Performance
Van den Ende Lecturer, University of Cape Town Faculty of Medicine
Margaret L. Rand
Chair, Review Committee, Heart & Stroke Foundation of Ontario,
Research and Development
Michael J. Sole
Robert Beamish Leadership Award, Elected Fellow, AHA
Donna Stewart
Margaret Mead Memorial Lecturer, Sydney, Australia
Robin Hunter Memorial Lecture, University of Toronto
Distinguished Member Award and Lecture, American Psychiatric
Association, New Orleans
Master Educator Clinical Consultation, American Psychiatric Association,
New Orleans
Duncan Stewart
Dexter H.C. Man Chair of Cardiology
MacDonald Lectureship (Queens)
Devornik Lectureship (Edmonton)
Richard D. Weisel
Awarded the Charles Tator Surgeon-Scientist Mentoring Award,
University of Toronto, Department of Surgery Gallie Day, 2002
Carin Wittnich
Carin Wittnich Teaching Assistant of the Year Award, 2001
Order of Ontario, 2001
Valedictorian, Order of Ontario, 2001
Local Hero, Volunteerism, The Barrie Examiner, Barrie, Ontario, 2002
Peer Reviewed Funding
Alter D, Naylor CD, Irvine J, Mustard C, Morgan C, Tu J, Wheaton B, Austin P: The
Relationship Between Socioeconomic Status, Quality of Care, and Outcomes Following Acute
Myocardial Infarction.
Canadian Institutes of Health Research, 2001-2004
Bendeck M: Tetracyclines in the Treatment of Vascular Disease.
Heart & Stroke Foundation of Ontario, 2001-2004
Bendeck M: Responses of Vascular Smooth Muscle Cells to Extracellular Matrix in
Atherosclerosis and Restenosis.
Canadian Institutes of Health Research, 2000-2003
Bendeck M: Ministry of Energy Science and Technology Ontario and Department of Laboratory
Medicine and Pathobiology.
Premier’s Research Excellence Award, 2000-2005
Cernacek P, Rouleau JL, Stewart DJ: Endothelin Blockade in Heart Failure and Hypertrophy:
Which Receptor and when?
Medical Research Council of Canada, 2000-2004
Cheung AM, Cameron JI, Hyman I, Franche RL, Stewart DE: Predicting Emotional Distress in
Family Caregivers: Analysis of the Longitudinal National Population Health Survey Data.
National Health Research and Development Program, 2003
Cheung AM, Cameron J, Stewart DE, Coyte PC, Streiner DL, Feldberg GD: When Home Care
Ends and Institutional Care Begins: A Longitudinal Study of Stroke Survivors and Their Family
Caregivers.
Social Sciences and Humanities Research Council, 2001-2004
Cheung A, Liu P, Abramson B, Stewart DE: Clinical Trial of Raloxifene Use in the Heart
(RUTH).
Eli Lilly, 1998-2003
Cohen J, Ashley MJ, Ferrence R, Stewart DE, Kyle K: Institutional Addiction to Tobacco:
Defining Links Between Canadian Universities and Medical Schools.
National Cancer Institute of Canada, 2000-2002
Coles JG, G Hannigan: Xenogenic Cardiomyocyte Transplantation.
Heart & Stroke Foundation of Ontario, 2000-2002
Coles JG, G. Hannigan: Integrin-Linked Kinase (ILK) Improves Cardiomyocyte Survival.
Canadian Institutes of Health Research, 2002-2005
Connelly PW: The Role of Apolipoproteins in Oxidation and Atherosclerosis.
Heart & Stroke Foundation of Ontario, 2002-2005
Deber R, Halman M, Millson P, Meyers T, Stewart DE, Urowitz S, Walmsley S, Bauman A:
Preferred Role of People with HIV and AIDS in Treatment Decision Making.
Ontario HIV Treatment Network, 1999-2001
Demeules M, Stewart DE (PI’s): Canadian Women’s Health Status Report: A Multidimensional
Look at the Health of Canadian Women.
Canadian Population Health Initiative, 2001-2003
Ethier CR: Computational Hemodynamics
National Science and Engineering Research Council, 2001-2005
Ethier CR: The Hydrodynamics of Aqueous Humor Outflow.
National Institutes of Health (subgrant), 1998-2002
Ethier CR: Protein Profiling in Human Trabecular Meshwork.
Glaucoma Research Society of Ontario, 2001-2002
Ethier CR: Human Anterior Segment Model for Myocilin Perfusion.
Hildegard Dorenhamp-Gerhard Zbinden Foundation, 2000-2001
Ethier CR: Factors Controlling Aqueous Outflow Resistance in Glaucoma.
Canadian Institutes of Health Research, 2001-2004
Feindel CM: Prolonged Storage of Cardiac Allografts with Shed Donor Blood.
Heart & Stroke Foundation of Ontario, 1999-2001
Feindel CM, Borger M: Effect of Vacuum Assist on Cerebral Microemboli During CPB.
The Physicians’ Services Incorporated Foundation, 2000-2001
Feindel CM, Rao V: Preservation of Endothelial Function Following Prolonged Storage of
Cardiac Allografts with Shed Donor Blood.
Heart & Stroke Foundation of Ontario, 2001-2004
Flanagan JG (PI), Ethier CR (Co-Investigator): The Role of Lamina Cribrosa Biomechanics
and Ischemia in Glaucomatous Optic Neuropathy.
Canadian Institutes of Health Research, 2001-2005
Floras J: Career Investigator Award, CI.
Heart & Stroke Foundation of Ontario, 2001-2006
Floras J: Cardiopulmonary Interactions in Health and Disease.
Medical Research Council of Canada, 2000-2005
Floras J: Cardiovascular Regulation in Men and Women with Hypertension of Heart Failure.
Heart & Stroke Foundation of Ontario, 1999-2002
Floras J: Peptidergic and Purinergic Modulation of the Autonomic Nervous System in Humans.
Medical Research Council of Canada, 1997-2002
Floras J (Co-Investigator): Investigations Concerning the Control and Modulation of Cardiac
and Renal Sympathetic Activity in Chronic Heart Failure
Heart & Stroke Foundation of Ontario, 2001-2004
Floras J (Co-Investigator): Multicentre Trial of Continuous Positive Airway Pressure (CPAP)
for Chronic Therapy of Heart Failure.
Medical Research Council of Canada, University-Industry Grant, 1998-2003
Floras J (Co-Investigator): Endothelial Dysfunction in SLE: Its Contribution to Abnormalities
in Coronary Perfusion and the Role of ACE Inhibition.
Heart & Stroke Foundation of Ontario, 2001-2003
Floras J: By What Mechanisms Does Conversion from Conventional Intermittent Dialysis to
Nocturnal Hemodialysis Lower Blood Pressure?
Canadian Institutes of Health Research
Fremes SE, Cohen E, Naylor CD, Fradet G, Buller C, Able J, Carrera R, Gelfand E, Tymchak
W, Menkis A, Almond D, Myers M, Errett L, Watson R, Yau T, Schwartz L, Rubens F,
Higginson L, Carrier M, Cote G, Morin J, Doyle D, Gleeton O: Multi Centre Radial Artery
Patency Study.
Medical Research Council, 2001
Fremes SE, Multi-Centre Radial Artery Study Participants: Multi-Centre Radial Artery Patenty
Study: 5 Year Results.
Canadian Institutes of Health Research, 2006
Gotlieb AI: Studies on Valvular Interstitial Cells and Valvular Repair.
Heart & Stroke Foundation of Ontario, 1999-2002
Gotlieb A (PI), Bendeck M (Co-Investigator): Heart Valve Repair: Regulation by Cells and
Matrix.
Heart & Stroke Foundation of Ontario, 2002-2005
Gotlieb AI, Langille BL (Co-Applicants): The Endothelium in Atherogenesis: Influences of
Hemodynamic Stresses.
Canadian Institutes of Health Research, 2001-2006
Hebert PC, Multi-Centre Study Participants (including Fremes, SE): Blood Conservation Using
Antifibrinolytics: A Randomized Trial in High Risk Cardiac Surgery – The BART Trial.
Canadian Institutes of Health Research, 2005
Henkelman M, Bronskill M, Foster S, Plewes DB, Yaffe M, Rowlands J, Wright GA: Medical
Imaging for Cancer.
National Cancer Institute of Canada, 2001-2006
Hinek A: Elastin Receptor in Pathobiology of Arterial Thickening.
Canadian Institutes of Health Research, 2001-2006
Hinek A (Co-Investigator): Pathobiology of Intimal Plaques.
Canadian Institutes of Health Research, Group Grant, 2001-2006
Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.
Canadian Institutes of Health Research, 2001-2004
Husain M: Conditional Expression of PMCA Isoforms in Arterial Smooth Muscle of
Transgenic Mice.
Heart & Stroke Foundation of Ontario, 2000-2003
Husain M: Molecular Physiology of Vascular Smooth Muscle.
Ontario Research & Development Challenge Fund New Opportunities Matching Grant,
2000-2003
Husain M: Mouse Models of Vascular Injury.
University of Toronto Faculty of Medicine Dean’s Fund, 1999-2002
Husain M: Molecular Physiology of Vascular Smooth Muscle.
Canada Foundation for Innovation New Opportunities Award, 1998-2002
Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.
Medical Research Council of Canada, 1998-2001
Husain M: Molecular Regulation of Vascular Smooth Muscle Cell Proliferation.
Medical Research Council of Canada, 1998-2001
Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.
Heart & Stroke Foundation of Ontario, 1998-2001
Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.
University of Toronto Connaught Foundation & Department of Medicine New Staff Grant
Hyman I, Stewart DE, Williams J, Ferris L, Cohen M, Maher J: Women’s Health Status in
Ontario.
Ontario Ministry of Health, 2001
Jenkins DJA (PI), Connelly PW (Co-Investigator)
Heart & Stroke Foundation of Ontario, 2002-2005
Katz J, Gagliese L, Snijdelaar D, Stewart DE, Macrae H, Taddio A, Sandler P: Gender
Differences in Pain and Analgesic Response to Kappa & Mu Opioids after Surgery.
Medical Research Council, 2000-2003
Langille BL (Director), Bendeck M, Cybulsky M, Husain M, Gotlieb A, Marsden P, Stewart
D, Strauss B, Ward M (Co-Investigators): Cell Biology of Atherosclerosis.
Heart & Stroke Foundation of Ontario Group Grant, 2000-2005
Langille BL (Director), Gotlieb AI (Member): New Frontiers Program in Restenosis after
Interventions: Pathobiology, Genetics and Therapeutics.
Canadian Institutes of Health Research, 2001
Lesperance F (PI), Dorian P (Co-Investigator): A Randomized Controlled Trial of Interpersonal
Psychotherapy and Citalopram for Depression in Coronary Artery Disease.
Canadian Institutes of Health Research, 2001-200.
Leytin V, Freedman J, Blanchette VS, Rand ML (Co-Investigator): Enhanced Diagnosis and
Characterization of von Willebrand Disease by Testing Platelet Activation and Function Under
Shear Rate Conditions
Aventis Behring Canada Research and Education Fund, 2001-2002
Li R-K: Career Investigator Award.
Heart & Stroke Foundation of Ontario, 2001
Li R-K, Weisel RD: Angiogenesis by Uterine Cell Transplantation.
Heart & Stroke Foundation of Ontario, 2001-2003
Li R-K, Weisel RD: Autologous Tissue-Engineered Grafts for Congenital Heart Surgery.
Heart & Stroke Foundation of Ontario, 2001-2003
Li R-K, Weisel RD: Cell Transplantation for Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2001-2006
Li R-K: Cell Transplantation to Improve Heart Function.
Ontario Ministry of Energy, Science and Technology, 2001-2006
Li R-K: Prevention of the Progressive Cardiac Failure of Dilated Cardiomyopathy by GeneTransfected Cell Transplantation.
Canadian Institutes of Health Research, 2001-2004
Li R-K: Cell Transplantation for Diabetic Cardiomyopathy.
Canadian Diabetes Association, 2002-2004
Lindsay T: Mechanistic Studies in Organ Injury After Ruptured Aortic Aneurysm.
Physicians’ Services Incorporated, 2002
Lindsay T: Ruptured Abdominal Aortic Aneurysm: Early Organ Injury Prevention Strategies.
Physicians’ Services Incorporated, 2002
Liu P, Backx P, Husain M, Parker T, Rabinovitch M, Rouleau JL, Sole MJ, Stewart DJ:
The Determinants of Host Response and Sesceptibility in the Development of Health Network.
Canadian Institutes of Health Research Group Grant, 2001-2004
Liu P (Director), Backx P, Parker T, Rabinovitch M, Rouleau JL, Stewart DJ, Husain M:
The Determinants of Host Susceptibilities of Heart Failure.
Canadian Institutes of Health Research Group Grant, 2000-2003
Magee L, von Dadelszen P, Guyatt G, Koren G, Ross S, Stephenson M, Stewart DE: Measuring
Quality of Life in Nausea and Vomiting of Pregnancy (NVP): Assessment of the Measurement of
a New Evaluation Questionnaire.
The Vancouver Foundation, 2001-2002
Mazer D: The Role of Anemia and Red Blood Cell Substitutes in Traumatic Brain Injury.
Anemia Institute for Research and Education, 2002
Mazer D (Co-Investigator): Blood Conservation Using Antifibrinolytics: A Randomized Trial
in a Cardiac Surgery Population – The BART Study.
Canadian Institutes of Health Research, 2002
Mazer D (Co-Investigator): A Randomized Trial of a Lung-Open Ventilation Strategy (LOVS)
in Acute Lung Injury.
Canadian Institutes of Health Research, 2002-2003
Mazer D (Co-Investigator): CABG Surgery in USA, Canada, Germany and the United
Kingdom: Comparison of Timelines and Outcomes.
Ischemia Research and Education Foundation, 2001-2002
Mazer D (Co-Investigator): Atrial Fibrillation Risk Indices for Patients Undergoing CABG.
Ischemia Research and Education Foundation, 2001-2002
Merchant N, Mickleborough LL: Magnetic Resonance Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 2001-2002
Mickleborough LL (for Canada), Multi-Centre Trial across North America: Surgical Treatment
for Ischemic Heart (STICH) Failure Trial.
National Institutes of Health U.S., 2001-2004
Nag S, Stewart DJ: Regulation of Cerebrovascular Homeostasis and Repair by Angiogenic
Factors.
Heart & Stroke Foundation of Canada, 2000-2002
Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s), (Co-Applicants) Angus J, Rouleau JL,
Franche R-L, Rosser W, Alter D, Picard L, Michel I, Crichton T, Haider L, Micevski V, Grace S:
Community Outreach and Heart Health Risk Reduction Trials (COHRT).
Heart & Stroke Foundation of Ontario, 2001-2005
Osmond D: New Hypertensive System Linked to Blood Coagulation FXII.
Heart & Stroke Foundation of Ontario, 2002
Peltier R (PI), Ethier CR (Co-Investigator): PsciNet II Computing Upgrade.
CFI/OIT/Compaq Canada, 2002-2003
Plewes DB (PI), Wright GA (Co-Investigator): Centre for Research Using Magnetic
Resonance at Sunnybrook and Women’s College Health Sciences Centre
Medical Research Council of Canada, 1999-2002
Rabinovitch M (Director), Bruneau B, Hinek A, Husain M, Keely F, Wilson G:
Interdisciplinary Program in Cardiovascular Development and Disease.
Canadian Institutes of Health Research Group Grant, 2000-2005
Rand ML, Freedman J: The Procoagulant Surface of Activated Platelets: Persistence in vitro
and in vivo
Heart & Stroke Foundation of Ontario, 2001-2004
Rowlands J, Keep D, Burns P, Chauhan V, Cohen E, Fort S, Foster S, Fremes SE, Stewart D,
Wilson B, Wright G: Imaging Research Centre for Cardiac Intervention – IRCCI.
Canada Foundation for Innovation, 2005
Roy D (PI), Dorian P (Co-Investigator): AF CHF Trial.
Canadian Institutes of Health Research, 2001
Singer P, Cheung A, Deber R, Dickens B, Flood, Lemmens T, Mullen M, Mykitiuk R, Robertson
A, Stewart DE, Till J: Canadian Program on Genomics and Global Health: International and
Comparative Perspectives on Health Systems and Insurance Implications of New Genetic
Testing.
Genome Canada, 2001-2006
Stamer WD (PI), Ethier CR (Co-Investigator): Role of Aquaporin-1 in the Permeability of
Schlemm’s Canal.
American Health Assistance Foundation, 2001-2002
Slutsky AS: Critical Care Unit for Research Excellence (CCURE) [Group grant including
approximately 20 critical care physicians/specialists from southern Ontario].
Canada Foundation for Innovation and Ontario Innovative Trust, 2002-2006
Sole M: The Genetics of Hypertrophic Cardiopathy.
Heart & Stroke Foundation of Ontario, 2000-2003
Sole M: Molecular Cardiology.
GH Wood Foundation, 2000-2005
Sole M: The Determinants of Host Response and Susceptibility in the Development of Heart
Failure.
Canadian Institutes of Health Research Group Grant, 2001-2004
Sole M (Co-Investigator): The Prevalence of Thiamine Deficiency in Hospital Patients with
CHF.
Canadian Foundation for Dietitic Research, 2000-2001
Stewart D (PI), Husain M (Co-Investigator): Targeted Overexpression of Inducible NO
Synthase: Relevance for the Pathogenesis of Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2002-2005
Stewart D (PI), Husain M (Co-Investigator): Pathophysiological Relevance of Endothelin-1
Overexpression.
Canadian Institutes of Health Research, 2001-2004
Stewart DE, Ahmad F: Popular Health Promotion Strategies Among Chinese and East Indian
Immigrant Women.
Social Sciences and Humanities Research Council, 2001-2003
Stewart DE, Ahmad F: The Use of Community Newspaper to Promote Breast Cancer Screening
Among South Asian Women.
Canadian Breast Cancer Foundation: Ontario Chapter, 2002
Stewart DJ: Biological and Therapeutic Potential of Angiopoietins.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ: Clinical Relevance of Endothelial Dysfunction.
Medical Research Council of Canada, 1995-2002
Stewart DJ, et al: Cardiovascular Gene Therapy Initiative.
Canada Foundation for Innovation, 2001-2004
Stewart DJ, et al: Multicentre Randomized Double Blind Placebo Control Clinical Trial of
DNA for VEGF165 in the Treatment of Angina Pectoris
Canadian Institutes of Health Research/University/Industry, 2001-2004
Stewart DJ, Fitchett DH, Batchelow WB: Controlled Trial of VEGF DNA in Severe Angina.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ, Husain M: Pathophysiological Relevance of Endothelin-1 Overexpression.
Canadian Institutes of Health Research, 2001-2005
Stewart DJ, Monge JC: Differential Expression of Endothelial Factors in Angiogenesis.
Medical Research Council of Canada, 1996-2001
Stewart DJ: New Frontiers Program “Gene and Cell-Based Therapies for Cardio-Respiratory
Disorders”.
Heart & Stroke Foundation of Canada/CIHR, 2001-2002
Tu J, Chan B, Naylor CD: Quality of Acute Myocardial Infarction Care.
Canadian Institutes of Health Research, 2000-2005
Tu J, Fremes SE: Canadian Cardiovascular Outcomes Research Team.
Canadian Institutes of Health Research – Interdisciplinary Health Research Team, 2005
Verma S, Weisel RD: Endothelin Antagonism and Cardiac Surgery in Diabetes.
Physicians’ Services Incorporated Foundation, 2001-2002
Weisel RD: Protection from Perioperative Ischemia.
Heart & Stroke Foundation of Ontario, 1999-2002
Weisel RD: Protection from Perioperative Ischemia.
Heart & Stroke Foundation of Ontario, 2001-2004
Weisel RD: Endothelin, Perioperative Ischemia and Diabetes.
Canadian Diabetes Association, 2001-2003
Wilson GJ, Backx PH: Ischemic Preconditioning of the Myocardium: Role of Chloride
Channels.
Heart & Stroke Foundation of Ontario, 1999-2002
Wilson GJ (PI), Courtman DW (Co-Investigator): Acellular Matrix: Tissue Engineering
Approaches for Pediatric Cardiovascular Reconstruction.
Canadian Institutes of Health Research, 2000-2003
Wittnich C: Chronically Hypoxic Newborn Hearts Response to Stress.
Heart & Stroke Foundation of Ontario, 1999-2002
Wittnich C: Impact of Gender on Myocardial Pathology & Ischemia/Reperfusion.
Heart & Stroke Foundation of Ontario, 2001-2004
Wright GA: Evaluation of Myocardial Ischemia with MRI.
The Premier’s Research Excellence Award, 1999-2002
Wright GA: Magnetic Resonance Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 2000-2005
Wright GA, Burns P, Coates G, Downar E, Fort S, Hendler A, Hu B, McKerlie C, Merchant N,
Mickleborough L, Wittnich C: Magnetic Resonance Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 1999-2003
Wright GA, Merchant N, Rubin BB: Magnetic Resonance Imaging for Ischemia.
Medical Research Council of Canada, 2000-2005
Wright GA, Prato F: Ontario Consortium for Cardiac Imaging.
Ontario Research and Development Challenge Fund, 2000-2005
Yau TM, Weisel RD: Insulin Cardioplegia for Poor Left Ventricular Function.
Heart & Stroke Foundation of Ontario, 2001-2003
PUBLICATIONS
STUDENTS
Ahmed Z, Ravandi A, Maguire GF, Emili A, Draganov D, La Du BN, Kuksis A, Connelly PW:
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite.
Biochem Biophys Res Comm, 2002;290:391-396.
Ahmed Z, Ravandi A, Maguire GF, Kuksis A, Connelly PW: Aminoguanidine forms Schiff’s
base adducts with phosphatidylcholine core aldehydes as part of its antioxidant activity. Clin
Chem, 2001;47(6):A54.
Azakie A, Merklinger S, McCrindle BW, Van Arsdell G, Benson LN, Lee K-J, Coles JG,
Williams WG: Evolving strategies and improving outcomes of the modified Norwood
procedure: A 10-year single-institution experience. Ann Thorac Surg, 2001;72:1349-1353.
Azakie A, Merklinger S, Williams WG, Van Arsdell GS, Coles JG, Adatia I: Improving
outcomes of the Fontan operation in children with atrial isomerism and heterotaxy syndromes.
Ann Thorac Surg, 2001;72:1636-1640.
Bandali KS, Belanger MP, Wittnich: Is hyperglycemia seen in neonates during cardiopulmonary
bypass due to hyperoxia? J Thorac Cardiovasc Surg, 2001;122(4):753-758.
Barolet A, Nili N, Cheema A, O’Blenes S, et al: Arterial elastolytic activity after angioplasty
and the effects of elafin, an elastase inhibitor. Arterioscler Thromb Vasc Biol, 2001;21:12691274.
Belanger MP, Wittnich C, Torrance SM, Juhasz S: Model of normothermic long-term
cardiopulmonary bypass in swine weighing more than eighty kilograms. Comp Med,
2002;52(2):117-121.
Bhagawan K, Merklinger S, Van Arsdell GS, McCrindle BW, Borger MA, Caldarone CA,
Coles JG, Williams WG: Extending the usable size range of homografts in the pulmonary
circulation: Outcome of bicuspid homografts. Ann Thorac Surg, 2002;73:866-870.
Blais Jr, C, Lapointe N, Rouleau JL, Clement R, Bachvarov DR, Adam A: Effect of captopril
and omapatrilat on early post-myocardial infarctions survival and cardiac hemodynamics in rats:
Interaction with cardiac cytokine expression. Can J Physiol & Pharmacol, 2002;80:48-58.
Campbell AIM, Zhao Y, Sandhu R, Stewart DJ: Cell-based transfer of VEGF attenuates
monocrotaline-induced pulmonary hypertension. Circulation, 2001;104:2242-2248.
Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR
measures of pressure with microbubbles. Magnetic Resonance in Medicine, 2002;47:264-273.
Dumont AS, Hyndman ME, Dumont RJ, Fedak PWM, Kassell NF, Sutherland GR, Verma S:
Improvement of endothelial function in insulin-resistant carotid arteries treated with pravastatin.
J Neurosurg, 2001;95:466-471.
Fedak PWM, Verma S, Weisel RD, Mickle DAG, Li R-K: Angiogenesis: Protein, gene or cell
therapy. Heart Surg Forum, 2001;4:301-304.
Gori T, Burstein J, Ahmed S, Miner S, Al-Hesayen A, Parker JD: Folic acid prevents
nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance. Circulation,
2001;104(10:1119-1123.
Gori T, Mak SS, Kelly S, Parker JD: Evidence supporting abnormalities in nitric oxide synthase
function induced by nitroglycerin in humans. J Am Coll Cardiol, 2001;38(4):1096-1101.
Hinek A, Riazi S: The role of elastin in modulation of cellular proliferation. Mol Biol Cell,
2001;12:65a.
Jurt U, Gori T, Ravandi A, Babaei S, Zeman P, Parker JD: Differential effects of pentaerythritol
tetranitrate and nitroglycerin on oxidative stress and nitrate tolerance development. A human in
vivo study. J Am Coll Cardiol, 2001;38(3):854-859.
Koirala B, Merklinger SL, Van Arsdell GS, McCrindle BW, Borger MA, Calderone C, Coles
JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation:
Outcome of “bicuspid homografts”. Ann Thorac Surg, 2002;73(3):866-869; discussion 869-870.
Lapointe N, Rouleau JL: Activation of vascular tissue angiotensin converting enzyme (ACE) in
heart failure: Effects of ACE inhibitors. J Am Coll Cardiol, 2002;39(5):776-779.
Miriuka S, Rao V, Weisel RD, Li SH, Anderson TJ, Maitland A, Fedak PWM, Li R-K, Verma
S: Cyclosporin induced endothelial dysfunction: Effects of the nitric oxide cofactor,
tetrahydrobiopterin. J Heart Lung Transplant, 2002;21(1):130-131.
Nguyen QT, Cernacek P, Sirois MG, Calderone A, Lapointe N, Stewart DJ, Rouleau JL: Longterm effects of non-selective endothelin A and B receptor antagonism in post-infarction rat:
Importance of timing. Circulation, 2001;104:2075-2081.
Parker JD, Gori T: Tolerance to the organic nitrates: New ideas, new mechanisms, continued
mystery. Circulation, 2001;104:2263-2265.
Qi X, Varma P, Newman D, Mamalias N, Dorian P: Terikalant, an IK1 and IKr blocker, decreases
the area of vulnerability to ventricular fibrillation induction by T wave shocks in dogs. J
Cardiovasc Pharmacol, 2002;39(2):242-250.
Riazi S, Chitayat D, Urban Z, Hinek A: The role of elastin in modulation of cellular
proliferation. Can J Cardiol, 2001;17(Suppl C):242C.
Shiono L, Rao V, Weisel RD, Kawasaki M, Li R-K, Mickle DAG, Fedak PWM, Tumiati L,
Verma S: L-arginine protects human heart cells from low-volume anoxia and reoxygenation. Am
J Physiol: Heart Circ Physiol, 2002;282:H805-H815.
Sia YT, Lapointe N, Parker TG, Tsoporis JN, Deschepper CF, Calderone A, Pourdjabbar A,
Jasmin JF, Sarrasin JF, Liu P, Adam A, Butany J, Rouleau JL: Beneficial effects of long-term
use of the antioxidant probucol in heart failure in the rat. Circulation, 2002;105(21):2549-2555.
Torrance SM, Wittnich C: Post ischemic functional recovery in immature hearts is influenced
by performance index and assessment technique. Am J Physiol: Heart & Circ, 2001;281:H2446H2455.
Urban Z, Riazi S, Seidl TL...Boyd CD, Hinek A: Connection between elastin haploinsufficiency
and increased cell proliferation in patients with supravalvular aortic stenosis and WilliamsBeuren Syndrome. Am J Hum Genet, 2002;71(1):30-44.
Van Soeren M, Micevski V: Indicators and barriers to successful role implementation for acute
care nurse practitioners in 4 Ontario hospitals. AACN Clinical Issues, 2001;12(3):424-437.
Verma S, Li S-H, Badiwala MV, Weisel RD, Fedak PWM, Li R-K, Dhillon B, Mickle DAG:
Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of creactive protein. Circulation, 2002;105(16):1890-1896.
Verma S, Maitland A, Weisel RD, Fedak PWM, Li SH, Mickle DAG, Li R-K, Ko L, Rao V:
Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion
impairs coronary vascular reactivity: Reversal by means of endothelin antagonism. J Thorac
Cardiovasc Surg, 2002;123(6):1114-1119.
Verma S, Maitland A, Weisel RD, Fedak PWM, Pomroy NC, Li SH, Mickle DAG, Li R-K, Rao
V: Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation:
Identifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg,
2002;123(6):1074-1083.
Verma S, Maitland A, Weisel RD, Li SH, Fedak PWM, Pomroy NC, Mickle DAG, Li R-K, Ko
L, Rao V: Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury:
Reversal with endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1120-1124.
Verma S, Fedak PWM, Weisel RD, Butany J, Rao V, Maitland A, Li R-K, Dhillon B, Yau TM:
Fundamentals of reperfusion injury for the clinical cardiologist. Circulation, 2002;105:23322336.
Wallen WJ, Belanger MP, Wittnich C: Body weight and food intake profiles are modulated by
sex hormones and tamoxifen in chronically hypertensive rats. J Nutrition, 2002;132:1-5.
Wallen WJ, Belanger MP, Wittnich C: Sex hormones and the selective estrogen receptor
modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult
rats. J Nutrition, 2001;131:2351-2357.
Wittnich C, Belanger MP, Wallen JW, Torrance SM, Juhasz S: A long-term stable
normothermic cardiopulmonary bypass model in neonatal swine. J Surg Res, 2001;101:176-182.
Wong AYH, Kulandavelu S, Whiteley KJ, Qu D, Langille BL, Adamson SL: Maternal
cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol: Heart & Circ,
2002;282:H918-H925.
Yang L, Tuan L, Newman ER: Structure of the LRP-regulated serA promoter of E. coli K-12.
Mol Microbio, 2002;43(2):323-333.
FACULTY
Adeli K, Taghibiglou C, Carpentier A, Lewis GF: Mechanisms of hepatic very low-density
lipoprotein overproduction of VLDL in insulin resistance. Trends in Cardiovasc Med,
2001;11(5):170-176.
Afroze T, Husain M: Cell cycle-dependent regulation of intracellular calcium concentration in
vascular smooth muscle cells: A potential target for drug therapy. Curr Drug Targets –
Cardiovasc & Haematol Dis, 2001;1:23-40
Ahmad F, Gupta H, Rawlins J, Stewart DE: Preferences for gender of family physicians among
Canadian European-descent and South Asian immigrant women. Family Practice, 2002;19:146153.
Ahmed Z, Ravandi A, Maguire GF, Emili A, Draganov D, La Du BN, Kuksis A, Connelly PW:
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite.
Biochem Biophys Res Comm, 2002;290:391-396.
Ahmed Z, Ravandi A, Maguire GF, Kuksis A, Connelly PW: Aminoguanidine forms Schiff’s
base adducts with phosphatidylcholine core aldehydes as part of its antioxidant activity. Clin
Chem, 2001;47(6):A54.
Al-Sannaa N, Forrest CR, Teebi AS: Trigonomicrocephaly, severe micrognathia, large ears,
atrioventricular septal defect, symmetrical cutaneous syndactyly of hands and feet and multiple
cafe-au-lait spots: New acrocraniofacial dysostosis syndrome? Am J Med Gen, 2001;101:279282.
Alter DA, Naylor CD, Austin PC, Tu JV: Factoring socioeconomic status into cardiac
performance profiling for hospitals: Does it matter? Medical Care, 2002;40(1):60-67.
Alter DA, Naylor CD, Austin PC, Tu JV: Long-term MI outcomes at hospitals with or without
on-site revascularization. JAMA, 2001;285(16):2101-2108.
Atkins DL, Dorian P, Gonzalez ER, et al: Treatment of tachyarrhythmias. Ann Emerg Med,
2001;37(4Pt2):S91-S109.
Austin LA, Ahmad F, McNally MJ, Stewart DE: Breast and cervical cancer screening in
Hispanic women: A literature review using health belief model. Women’s Health Issues,
2002;12:122-128.
Azakie A, McCrindle BW, Van Arsdell GS, Benson LN, Coles JG, Hamilton R, Freedom RM,
Williams WG: Extracardiac conduit versus lateral tunnel cavopulmonary connections at a single
institution: Impact on outcomes. J Thorac Cardiovasc Surg, 2001;122(6):1219-1228.
Azakie A, Merklinger S, McCrindle BW, Van Arsdell G, Benson LN, Lee K-J, Coles JG,
Williams WG: Evolving strategies and improving outcomes of the modified Norwood
procedure: A 10-year single-institution experience. Ann Thorac Surg, 2001;72:1349-1353.
Azakie A, Merklinger S, Williams WG, Van Arsdell GS, Coles JG, Adatia I: Improving
outcomes of the Fontan operation in children with atrial isomerism and heterotaxy syndromes.
Ann Thorac Surg, 2001;72:1636-1640.
Azevedo ER, Kubo T, Mak S, Al-Hesayen A, Newton GE, Floras JS, Parker JD: Nonselective
versus selective adrenergic receptor blockade in congestive heart failure: Differential effects on
sympathetic activity. Circulation, 2001;104:2194-2199.
Azevedo ER, Stewart DJ, Parker JD: Increased extraction of endothelin-1 across the failing
human heart. Am J Cardiol, 2001;88(2):180-182.
Bandali K, Belanger MP, Wittnich C: Is hyperglycemia seen in children during
cardiopulmonary bypass a result of hyperoxia? J Thorac Cardiovasc Surg, 2001;122(4):753-758.
Barolet AW, Babaei S, Robinson R, Picard P...Stewart DJ, Strauss BJ: Administration of
exogenous endothelin-1 following vascular balloon injury: Early and late effects on intimal
hyperplasia. Cardiovasc Res, 2001;52(3):468-476.
Belanger MP, Wittnich C, Torrance SM, Juhasz S: Model of normothermic long-term
cardiopulmonary bypass in swine weighing more than eighty kilograms. Comp Med,
2002;52(2):117-121.
Bellingham CM, Woodhouse K, Robson P, Rothstein S, Keeley FW: Self-aggregation
characteristics of recombinantly expressed human elastin polypeptides. Biochim Biophys Acta,
2001;1550:6-19.
Bendeck M, Nakada M: The β3 integrin antagonist m7E3 reduces matrix metalloproteinase
activity and smooth muscle cell migration. J Vasc Res, 2001;38:590-599.
Bendeck MP, Conte M, Zhang M, Nafiseh N, Strauss B, Farwell S: Doxycycline modulates
smooth muscle cell growth, migration and matrix remodeling after arterial injury. Am J Path,
2002;160:1089-1095.
Bendeck MP: Matrix metalloproteinases: Are they anti-atherogenic but pro-aneurysmal? Circ
Res, 2002;90:836-837.
Bhagawan K, Merklinger S, Van Arsdell GS, McCrindle BW, Borger MA, Caldarone CA, Coles
JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation:
Outcome of bicuspid homografts. Ann Thorac Surg, 2002;73:866-870.
Black CE, Huang N, Neligan PC, Levine RH, Lipa JE, Lintlop S, Forrest CR, Pang CY: Effect
of nicotine on vasoconstrictor and vasodilator responses in human skin vasculature. Am J
Physiol: Regul Integr Comp Physiol, 2001;281:R1097-R1104.
Blais Jr, C, Lapointe N, Rouleau JL, Clement R, Bachvarov DR, Adam A: Effect of captopril
and omapatrilat on early post-myocardial infarctions survival and cardiac hemodynamics in rats:
Interaction with cardiac cytokine expression. Can J Physiol & Pharmacol, 2002;80:48-58.
Bonetta C, Cheung AM, Stewart DE: Italian-Canadian women’s views of menopause: How
culture may affect hormone use. Medscape Women’s Health, 2001;6(5).
Bonn V, Cheung RC, Chen B, Taghibiglou C, Van Iderstine S, Adeli K: Simvastatin, an HMGCoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells
and primary hamster hepatocytes. Atherosclerosis, 2002;163:59-68.
Borger MA, Feindel CM: Cerebral emboli during cardiopulmonary bypass: Effect of
perfusionist interventions and aortic cannulas. J Extra Corpor Technology, 2002;34:29-33.
Bradley TD, Lorenzi-Filho G, Floras JS: Pathophysiological interactions between sleep apnea
and the heart. IN: Respiratory-Circulatory Interactions in Health and Disease (Scharf S, Pinsky
M, Magder S, eds), Marcel Dekker, New York, 2001:577-611.
Brockhausen I, Lehotay M, Yang J-M, Wenshen Q, Young D, Lucien J, Coles JG, Paulsen H:
Glycoprotein biosynthesis in porcine aortic endothelial cells and changes in the apoptotic cell
population. Glycobiology, 2002;12:33-45.
Brown AL, Farhat W, Merguerian PA, Wilson GJ, Khoury AE, Woodhouse KA: 22 week
assessment of bladder acellular matrix as a bladder augmentation material in a porcine model.
Biomaterials, 2002;23(10):2179-2190.
Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH: The
influence of C3 deficiency on atherosclerosis. Circulation, 2002;105:3025-3031.
Butany J, Dias B, Iyengar P, Leask R, Brister S: Acute mitral regurgitation due to a torn porcine
bioprosthetic cusp. Circulation, 2002;105(10):e58-e60.
Butany J, Leask R: The failure modes of biological prosthetic heart valves. J Long-Term
Effects of Medical Implants, 2001;11:115-135.
Butany J: Pathogenetic heterogeneity of in-stent lesion formation in human peripheral arterial
disease. J Vasc Surg, 2002;35(4):820-822.
Cameron JI, Franche RL, Cheung AM, Stewart DE: Lifestyle interference and emotional
distress in family caregivers to advanced cancer patients. Cancer, 2002;94:521-527.
Campbell AIM, Zhao Y, Sandhu R, Stewart DJ: Cell-based transfer of VEGF attenuates
monocrotaline-induced pulmonary hypertension. Circulation, 2001;104:2242-2248.
Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart S, Christie DJ, Rand
ML: Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA100®). Br J Haematol, 2002;117:961-964.
Carpentier A, Taghibiglou C, Leung N...Buckingham R, Adeli K, Lewis GF: Ameliorated
hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer
protein expression and reduction in very low density lipoprotein assembly and secretion in the
fructose-fed hamster. J Biol Chem, 2002;277(32):28795-28802.
Chan C, Floras JS, Miller JA, Richardson RMA, Pierratos A: Regression of left ventricular
hypertrophy after conversion to nocturnal hemodialysis. Kidney International, 2002;61:22352239.
Chidambaram M, Duncan JA, Lai VS, Cattran DC, Floras JS, Scholey JW, Miller JA: Variation
in the renin angiotensin system throughout the normal menstrual cycle. J Am Soc Nephrology,
2002;13:446-452.
Clark RH, Gerstmann DR, Jobe AH, Moffitt ST, Slutsky AS, Yoder BA: Lung injury in
neonates: Causes, strategies for prevention and long-term consequences. J Pediatrics,
2001;139(4):478-484.
Cohen G, Christakis GT, Tamariz M...Rao V, Szalai JP, Fremes SE, Goldman BS: Are stentless
valves hemodynamically superior to stented valves? A prospective randomized trial. Ann Thorac
Surg, 2001;73:767-778.
Cohen G, Tamariz MG, Sever JY...Abouzahr L, Goldman BS, Fremes SE: The radial artery
versus the saphenous vein graft in contemporary CABG: A case-matched study. Ann Thorac
Surg, 2001;71:180-186.
Cohen J, Butany J, Leask RL, Desai ND, Lenkei S, Feindel CM: Chronic aortic dissection: 27
years after aortic valve replacement. Can J Cardiol, 2002;18(4):437-438.
Cohen MM, Schei B, Ansara D, Gallop R, Stuckless N, Stewart DE: A history of personal
violence and postpartum depression: Is there a link? Archives of Women’s Mental Health,
2002;4:83-92.
Cook D, Laporta D, Skrobik Y, Peters S, Sharpe M, Murphy P, Chin D, Crowther M:
Prevention of venous thromboembolism in critically ill surgery patients: A cross-sectional study.
J Crit Care, 2001;16(4):161-166.
Cook D, McMullin J, Hodder R, Heule M, Pinilla J, Dodek P, Stewart T, and the Canadian ICU
Directors Group: Prevention and diagnosis of venous thromboembolism in critically ill patients:
A Canadian survey. Crit Care, 2001;5:336-342.
Cunningham CH, Stainsby JA, Wright GA, Wood ML: Partial Discrete Fourier Transform
(PDFT) multiband encoding. Magnetic Resonance in Medicine, 2001;45:118-127.
David TE, Armstrong S, Ivanov J, Feindel CM, Omran A, Webb G: Results of aortic valvesparing operations. J Thorac Cardiovasc Surg, 2001;122(1):39-46.
David TE, Ivanov J, Eriksson MJ, Bos J, Feindel CM, Rakowski H: Dilation of the sinotubular
junction causes aortic insufficiency after aortic valve replacement with the Toronto SPV
bioprosthesis. J Thorac Cardiovasc Surg, 2001;122(5):929-934.
De Durante G, Del Turco M, Rustichini L, Cosimini P, Giunta F, Hudson LD, Slutsky AS,
Ranieri VM: ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive
end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Resp and Crit
Care Med, 2002;165(9):1271-1274.
Degousee N, Stefanski E, Lindsay TF, Rubin BB: p38 MAPK regulates group I1a
phospholipase A2 expression in interleukin – 1B stimulated rat neonatal cardiomyocytes. J
Biological Chem, 2001;276(47):43842-43849.
Dellgren G, Coles JG: Pediatric heart transplantation: Improving results in high-risk patients.
IN: Pediatric Cardiac Surgery Annual 2001 (Coles JG, Williams WG, eds). W.B. Saunders
Company, Philadelphia, 2001:103-113.
Dellgren G, Feindel CM, Bos J, Ivanov J, David TE: Aortic valve replacement with the Toronto
SPV: Long-term clinical and hemodynamic results. Eur J Cardiothorac Surg, 2002;21(4):698702.
Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR
measures of pressure with microbubbles. Magnetic Resonance in Medicine, 2002;47:264-273.
Dias B, Barolet A, Ralph-Edwards A, Graba J, Mohsen B, Butany J: Left atrial mass. Can J
Cardiol, 2002;18(1):82-85.
Dias B, El-Hajj H, Cusimano RJ, Graba J, Velups A, Butany J: Coexisting ventricular septal
aneurysms: Congenital and postmyocardial infarction. Can J Cardiol, 2001;17(11):1193-1196.
Dias B, Parker T, Ralph-Edwards A, Velups S, Butany J: Surgical myectomy in hypertrophic
cardiomyopathy. Can J Cardiol, 2001;17(10):1087-1089.
Dias B, Sassoon Z, Leask R, Yau T, Persaud J, Butany J: Right atrial mass. Can J Cardiol,
2001;17(12):1299-1304.
Dias B, Scully H, Black R, Iwanochko RM, Graba J, Butany J: Actue bacterial endocarditis on
myxomatous mitral valve. Can J Cardiol, 2001;17(9):983-985.
Diaz RJ, Batthish M, Backx PH, Wilson GJ: Chloride channel inihibition does block the
protection of ischemic preconditioning in myocardium. J Mol Cell Cardiol, 2001;33(10):18871889.
Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A: A randomized clinical trial of
amiodarone versus lidocaine in shock resistant out-of-hospital ventricular fibrillation. N Eng J
Med, 2002, March.
Dorian P, Koster RW, Chapman FW, Schmitt PW, O’Grady SG: External cardioversion of
atrial fibrillation with biphasic shocks requires less current and cases less pain discomfort. Acad
Emerg Med, 2001;8(5):543-544.
dos Santos CC, Zhang H, Slutsky AS: From bench to bedside: Bacterial growth and cytokines
(Commentary). Crit Care, 2002;6:4-6.
Durbin AD, Gotlieb AI: Advances towards understanding heart valve response to injury.
Cardiovascular Pathology, 2002;11:69-77.
Egri Z, Floras JS: Role of angiotensin II blockade in therapy of heart failure. IN: Harrison’s OnLine (Braunwald E. ed), McGraw-Hill, Doi.1036/1096/7133.edl3037
Emmett L, Iwanochko RM, Barolet A, Freeman M, Lee D, Husain M: Reversible regional wall
motion abnormalities on exercise Tc-99m gated cardiac SPECT predict high-grade angiographic
stenoses. J Am Coll Cardiol, 2002;39:991-998.
Ethier CR, Chan DW-H: Cationic ferritin changes outflow facility in human eyes while anionic
ferritin does not. Investigative Ophthalmology and Visual Sci, 2001;42:1795-1802.
Ethier CR: The inner wall of Schlemm’s canal. Experimental Eye Res, 2002;74:161-172
(Invited Review).
Exercise and Stress Response: The Role of Stress Proteins. (Locke M, Noble EG, co-eds), CRC
Press, Boca Raton, Florida, 2002.
Farb RI, McGregor C, Kim JK...Schwartz ML, Stainsby JA, Wright GA: Intracranial
arteriovenous malformations: Real-time auto-triggered elliptic centric-ordered 3D gadolinumenhanced MR angiography – initial assessment. Radiology, 2001;220(1):244-251.
Farkas LG, Katie MJ, Forrest CR, Litsas L: Surface anatomy of the face in Down’s Syndrome:
Linear and angular measurements in the craniofacial regions. J Craniofacial Surgery,
2001;12:373-379.
Farkas LG, Katie MJ, Forrest CR: Surface anatomy of the face in Down’s Syndrome:
Anthropometric proportion indices in the craniofacial regions. J Craniofacial Surgery
2001;12:519-524.
Fedak PWM, Verma S, Weisel RD, Mickle DAG, Li R-K: Angiogenesis: Protein, gene or cell
therapy. Heart Surg Forum, 2001;4:301-304.
Fialkov JA, Holy C, Forrest CR, Phillips JH, Antonyshyn OM: Post-operative infections in
craniofacial reconstructive procedures. J Craniofacial Surgery, 2001;12:362-363.
Floras JS, Butler GC, Ando S, Brooks S, Pollard MJ, Picton P: Differential sympathetic nerve
and heart rate power spectral responses to lower body negative pressure. Am J Physiol:
Regulatory Integrative and Comparative Physiol, 2001;281:R468-R475.
Floras JS: Morning activity and blood pressure-a cause for concern? J Hypertension,
2002;20:809-811 (Invited Editorial).
Floras JS: The ‘unsympathetic’ nervous system of heart failure. Circulation, 2002;105:17531755 (Invited Editorial).
Floras JS: Update on the Canadian Hypertension Society: Maintaining our strengths within an
evolving environment. Can J Cardiol, 2002;18:589-590 (Invited Editorial).
Floras JS: Vasopeptidase inhibition: A novel approach to cardiovascular therapy. Can J Cardiol,
2002;18:177-182.
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(This report is based on information provided by faculty and students.)
ACKNOWLEDGEMENTS:
The Cardiovascular Sciences Collaborative Program would like to thank the following for their
generous support:
Industry Sponsors
Bristol-Myers Squibb
Medtronic Canada
Merck Frosst Canada & Co.
Solvay Pharma
Individual Donors
Dr. Wilfred G. Bigelow, who has so generously supported the Program both morally and
financially.
And, the individuals that have given personal donations to support cardiovascular graduate
training at the University of Toronto.
- Michael Morassutti
- Stephen McDonald