CARDIOVASCULAR SCIENCES
COLLABORATIVE PROGRAM
Faculty of Medicine, University of Toronto
ANNUAL REPORT
2007 – 2008
FitzGerald Bldg., 150 College Street, Room 88, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: cv.program@utoronto.ca
Web site: www.cscp.utoronto.ca
CONTENTS
DIRECTOR’S REPORT………………………………………………………………………………….2
MISSION STATEMENT………………………………………………………………………………….3
COLLABORATING DEPARTMENTS…………………………………………………………………..3
COMMITTEES…………………………………………………………………………………………….4
- Executive
- Program
COURSES OFFERED…………………………………………………………………………………...5
PROGRAM SPONSORED ACTIVITIES……………………………………………………………….5
- Annual Student Research Day
- Student Forum Night
- Cardiovascular Summer Initiative - CSI
AWARDS…………………………………………………………………………………………………10
- Medtronic Travel Award
- Bigelow Book Prize
- Lorne Phenix Graduate Award
- Ontario Student Opportunity Trust Funds (OSOTF) Award
- Ontario Graduate Scholarships in Science and Technology (OGSST)
ADVERTISING MATERIAL…………………………………………………………………………….13
ACKNOWLEDGEMENTS………………………………………………………………………………13
STUDENTS………………………………………………………………………………………………14
- Currently Enrolled
- Convocated/Follow-Up
- Awards and Honors
- Publications
STUDENT ASSOCIATION SPONSORED ACTIVITY………………………………………………20
- Circulation Rounds
FACULTY………………………………………………………………………………………………...21
- Members
- Peer Reviewed Funding
- Awards and Honors
- Publications
1
DIRECTOR’S REPORT
Once again, it gives me great pleasure to provide this annual
report highlighting the Cardiovascular Sciences Collaborative
Program (CSCP) activities and accomplishments of our students
and faculty over the 2007-2008 academic year. Thanks are also
extended for the financial support from the Heart & Stroke
Foundation of Ontario, Medtronic Canada, and the university which
allowed the CSCP to continue to serve the university community,
enhancing the graduate student experience for all our member
Departments and Faculties.
The CSCP has shown a continued and sustained enrolment since
its inception in 1992 (see graph below), where we began with a
grand total of 5 students! The success of our recruitment initiative
is clearly shown as we now have a total of 56 (37 MSc and 19 PhD) enrolled students. The
level of student satisfaction with the Program continues to be high as expressed during their
annual meeting with the CSCP Student Affairs Committee Chair and the exit surveys we
conduct. It is very satisfying to witness the growth and development of the CSCP over the past
15 years and seeing its’ entrenchment as a successful educational initiative of the Faculty of
Medicine.
60
55
50
45
40
35
30
25
20
15
10
5
0
MSc
PhD
Total
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
Talks continue with our ongoing partnership with the University of Waterloo. We await the
Faculty legal minds to provide us with a final draft of a Memorandum of Agreement and it is my
fervent wish that the upcoming year will see this initiative become a reality.
We continue to experience increased enrolment in our graduate course offerings and now have
fully established web-based learning for the JCV3000 series of graduate courses. Live and
archived seminars are now fully integrated into our JCV3000 level courses, providing state-ofthe-art learning technology for our trainees. I welcome this direction, as do all the students, and
anticipate that this will also dove-tail nicely with our ongoing partnership initiatives.
With the progress made over the past year, our objectives for 2008-2009 are to continue with
the momentum established and to redouble our efforts in areas that have been slow to advance
– as detailed below:
2







Finalize the agreement and launch the joint initiative with the University of Waterloo
Further develop innovative curriculum to more appropriately serve the diverse nature of
this now multi-Faculty graduate training initiative
Continue developing endowments to provide permanent infrastructure support
Maintain active student recruitment
Graduate training grant applications for both local and external agencies
Further develop CME programs in cardiovascular sciences
Maintain high standards of our full web-based courses
As you read through this report, you will see that the Program continues to enrich our trainee’s
experiences. Specific details on all activities can be found on our web site at
www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Victoria
Simpson, our Business Officer, as well as the Executive Committee for their hard work and
contributions that have made the Cardiovascular Sciences Collaborative Program the success it
is today. And finally, I would like to take this opportunity to thank all our faculty and students for
another successful year and to those individuals who have continued to provide both moral and
tangible support for this Program.
Dr. Carin Wittnich, O.Ont.
Director, CSCP
Professor of Surgery & Physiology
Northrop Frye Scholar
MISSION STATEMENT
“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario
Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate
Studies, exists to give formal, organized expression to cardiovascular studies and research at
the graduate level. It builds on the strengths of all participating academic units, and other
agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative,
interdisciplinary training and research.”
The above mission is achieved by advertising and promoting the importance of, and
opportunities in, cardiovascular studies, by making known the results of such studies, by
recruitment of excellent students, and by coordinating the graduate collaborative program in
cooperation with the academic units in which they are registered. Students in this collaborative
program must fulfill the requirements of their home units as well as the Program. Upon
graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s
academic transcript and the Program will present the student with a certificate and gift.
COLLABORATING FACULTIES
Dentistry
Medicine
Nursing
Pharmacy
Physical Education and Health
3
COLLABORATING GRADUATE UNITS
Biomaterials and Biomedical Engineering
Dentistry
Exercise Sciences
Health Policy, Management & Evaluation
Laboratory Medicine and Pathobiology
Medical Biophysics
Medical Science
Nursing
Pharmaceutical Sciences
Pharmacology
Physiology
Public Health Sciences
Rehabilitation Science
SUPPORTING CLINICAL DEPARTMENTS
Anesthesia
Medicine
Surgery
COMMITTEES
Executive
The Executive Committee consists of 4 members of the Program Committee representing as
wide a range of disciplines as possible and includes the Director. They also act as Chairs of the
various subcommittees as noted beside their name. The Executive Committee provides student
counseling, screens applicants, provides advice and acts as a Steering Committee.
Dr. C. Wittnich (Fundraising)
Dr. M. Rand (Scholarships & Awards)
Dr. V. Rao (Membership/Curriculum)
Dr. S. Thomas (Student Affairs)
Program
The Program Committee consists of a representative from each collaborating department as
well as two student representatives. It administers the Program, selects the Director, and
generally meets twice per year.
C. Wittnich (Chair)
D. Brooks (Rehabilitation Science)
S. Wu (Pharmaceutical Sciences)
D. Mazer (Anesthesia)
J. Parker (Pharmacology)
S. Heximer (Physiology)
D. Steinman (Institute of Biomaterials and Biomedical Engineering)
M. Rand (Laboratory Medicine and Pathobiology)
V. Rao (Institute of Medical Science)
H. Tenenbaum (Dentistry)
4
S. Thomas (Exercise Sciences)
J. Tu (Health Policy, Management and Evaluation)
J. Watt-Watson (Nursing)
G. Wright (Medical Biophysics)
President, CSCP Student Association
Vice-President, CSCP Student Association
COURSES OFFERED
EXS5508H
JCV1060H
JCV3060H*
JCV3061H*
JCV3062H*
JCV3063H*
JEB1365H
JTC1331H
LMP1015H
LMP1504H
PSL1462H
Cardiovascular Disease and Exercise
Developmental Cardiovascular Physiology
Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal
Transduction
Advanced Topics in Cardiovascular Sciences – Hormones
Advanced Topics in Cardiovascular Sciences – Heart Function
Advanced Topics in Cardiovascular Sciences – Vascular
Ultrasound: Theory and Applications in Biology and Medicine
Biomaterials Science
Vascular Pathobiology
Cell and Molecular Biology of Cardiovascular Diseases
Molecular Aspects of Cardiac Function
* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating
departments.
Suggested Courses (Considered valuable but does not fulfill Program requirements)
CHL5201
Introducing Biostatistics for Students in Biological Sciences
LMP1404S
Cellular and Molecular Mechanisms of Disease
PSL1052H
Fundamentals on Ion Channel Function
PROGRAM SPONSORED ACTIVITIES
Annual Student Research Day
On February 21, 2008, the Cardiovascular Sciences Collaborative Program held its 9th Annual
Student Research Day. This was a fun-filled day that was attended by All CSCP trainees. Dr.
Wittnich began the day with her welcoming remarks. Selected students then presented their
research concepts, designs or results in a series of 10 minute presentations followed by a 5
minute question period. The presentations were especially polished and professional this year,
and covered a broad range of hot topics in cardiovascular research.
5
SESSION I: Chair -- Shathiyah Kulandavelu
9:15 Elissa Tepperman (MSc- Institute of Medical Science)
“Tacrolimus Preserves Endothelial-Dependent Vasomotor Function and Decreases
Sensitivity to Vasospasm”
9:30 Mitesh Badiwala (PhD – Institute of Medical Science)
“Donor Pretreatment with Hypertonic Saline Improves Coronary Artery Vascular
Function Post-Cardiac Transplantation”
9:45 Maral Ouzounian (PhD – Institute of Medical Science)
“Biomarkers to Distinguish Systolic from Diastolic Heart Failure”
10:00 Lara Gotha (MSc – Institute of Medical Science)
“Arterial Injury & Intimal Hyperplasia in Heparan Sulfate-Deficient Perlecan Mice: The
Effects of Induction of Perlecan”
10:15 Meghan Sauve (MSc – Institute of Medical Science)
“The Role DPP-4 Inhibition in the Cardiovascular System”
10.30 Geoffrey de Couto (MSc – Institute of Medical Science)
“cFLIP Modulates the Cardiac Hypertrophic and Fibrotic Response After PressureOverload and Angiotensin II Infusion”
SESSION 2: Chair -- Michael Ward
11:00 Tenille Ragoonanan (MSc – Department of Physiology)
“Acute Beta 1 Adrenergic Antagonism Inhibits Cerebral Oxygen Delivery Following
Severe Hemodilution in Rodents”
11:15 Luka Srejic (MSc – Department of Physiology)
“Spontaneous and Evoked Cortical Potentials in a Rat Focal Stroke Model In Vivo”
11:30 Katharine Currie (MSc – Department of Exercise Sciences)
“The Effects of Short-Term Endurance Exercise Training on Vascular Function in Young
Males”
11:45 Christy Hamilton (MSc – Department of Exercise Sciences)
“NF-kB Activation in Peripheral Blood Mononuclear Cells Following Short Term
Endurance Training”
12:00 Kumar Perampaladas (MSc – Department of Pharmacology)
“Effect of Rosiglitazone on Nitroglycerin-induced Endothelial Function”
12:15 Kieran Quinn (MSc – Department of Physiology)
“Human Neutrophil Peptides Induce Endothelial-Leukocyte Interaction and Accelerate
Foam Cell Formation”
The afternoon component of the Research Day was highlighted by our Visiting Guests, Dr.
Margaret Rand (R) and Dr. Saeid Babaei (L) -- two successful individuals in academia and
industry. An informal presentation was held where they
shared the highs and lows of their career paths and life
experiences with the students. Students were very
delighted to meet Drs. Rand and Babaei, and this session
was filled with enthusiastic discussions about their insights
into the possible career paths for the students.
6
Winners of the Bigelow Book Prize (Dr. Mitesh Badiwala, PhD/IMS, Supervisor: Dr. V. Rao), and
the Phenix Graduate Award (Emma O’Donnell, PhD/EXS, Supervisor: Dr. J. Goodman) were
announced. We were honoured to have the Bigelow and Phenix families present to hand out the
awards.
Dr. Bigelow’s daughter, Pixie (left), was present to award
the Bigelow Book Prize to Dr. Mitesh Badiwala (center)
with Dr. Carin Wittnich (right)
Mrs. Phenix’s daughter, Karthryn (left), was present to
award the Lorne Phenix Gradaute Award to Emma
O’Donnell (center) with Dr. Carin Wittnich (right)
Certificates and gifts were presented to those students who had successfully completed the
Cardiovascular Sciences Collaborative Program over the past year.
Adam Gwozda, MSc/IMS, Supervisor: Dr. M. Rand
Kirsteen Burton, MSc/CHL, Supervisor: Dr. G. Tomlinson
Danny Ramzy, PhD/IMS, Supervisor: Dr. V. Rao
This year's Research Day was again a successful event due to the combined efforts of many
people. The members of the Planning Committee (Albert Tsui, Tenille Ragoonanan, and Laura
Voicu) would like to thank everyone involved in making this day a success, including Drs. Rand
and Babaei, the student presenters, the session Chairs, Shathiyah and Mike, the CSCP
Business Officer, Ms. Victoria Simpson, and Dr. Wittnich, CSCP Director.
Student Forum Night
This event is an excellent opportunity for new students of the CSCP to meet one another and for
senior students to catch up with old friends, and develop relationships with the up and comers.
Discussions range from basic research, laboratory trials and triumphs, to future
academic/career directions. Connections for research collaboration, as well as friendships are
developed, and all those in attendance thoroughly enjoy the festive dinner and the change to
meet other students. Due to a lack of funding we were unable to provide the CSCP student
body with the 2007 CSCP Forum and Dinner. We hope to resume this event in 2008.
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Cardiovascular Summer Initiative (CSI) 2008
This summer, the CSCPSA once again organized and ran the very exciting and successful
Cardiovascular Summer Initiative. The series was targeted at undergraduate students involved
in cardiovascular summer research, and aimed to give students a more inclusive feel for the
field and to provide a broader frame of reference than just lab experience alone.
We began with an orientation session that outlined the role
of the CSCP and the goals of our student association.
Altogether, 18 students signed up for the Cardiovascular
Summer Initiative with great student representation from
research hospitals around the Toronto area (TGH, SMH,
Sick Kids, PMH).
The next event was a mini-symposium showcasing the
diversity of research within the CSCP. Six students within
the collaborative program gave presentations: Mike Sellan,
Kieran Quinn, Melanie Henriques, Christy Hamilton, Elissa Tepperman, and Andrew
Ramadeen. The students really enjoyed the talks and demonstrated interest by posing
meaningful questions about research methods and graduate studies in general.
CSI Mini Symposium 2008:
Mike Sellan – ‘The effects of iron-overload on heart function’
CSI Mini Symposium 2008:
Elissa Tepperman – ‘Tacrolimus preserves vasomotor
function and decreases sensitivity to vasospasm’
CSI Mini Symposium 2008:
Andrew Ramadeen – ‘The effect of fish oils on vulnerability in
atrial arrythmias’
8
The following three events were field trips/lab tours. Based on the feedback the CSCPSA
obtained from the graduating students from the year previous, the committee attempted to
structure this year’s outings in such a way that they would incorporate a diverse spectrum of
material relevant to cardiovascular research.
The first event planned by the committee was set for the Surgical Skills Centre at the Mount
Sinai Hospital. Students were kindly greeted by the staff and were informed, in a didactic
lecture, about the complexities of surgical training and the state-of-the-art resources found at
the Mount Sinai teaching hospital. Students were next taken for a tour of the facility, given the
opportunity to watch some medical students dissect various tissues, and provided with the
chance to ask questions on their facilities. Overall this day was well received by both staff and
students.
The second event comprised a tour of the exercise laboratories in the Athletic Centre at the
University of Toronto. Katharine Currie and Marc Busato,
current graduating master’s students in the CSCP, kindly
agreed to provide us with a tour of their research equipment
and materials. Students were split into two groups: in Marc’s
group students learned about VOmax and cardiac output
using a stationary bicycle (CSI students, Anne Battisti [L],
Tommy Rohani [M], with Mark Busato [R]), while in
Katharine’s group
(left) students learned
about blood pressure
and wave forms while she recorded a student's
cardiovascular function (Judy Qiang) while lying
stationary on a bed.
Once again, this tour was very successful. Students
provided excellent feedback and were genuinely
interested in the hands-on aspect of this outing.
The third event organized by the CSCPSA was a tour of the Imaging Centre at St. Michael’s
Hospital. Upon the organization of this event we were fortunate to have the opportunity to have
two physicians, Dr. Louis Wu and Dr. Vikram Prabhudesai, provide lectures and tours of their
facilities. The organization and willingness of the staff to cooperate with the CSCPSA was
excellent. They were timely and extremely generous in providing everyone with a hot lunch,
drink and dessert during the lecture sessions. Subsequent tours of the MRI and CT facilities
were extremely informative. Although both imaging departments were busy, both physicians
went out of their way to give an informative session with Q&As. At the end of the session, both
physicians were presented with a certificate from the CSCPSA in gratitude of their help with the
program.
The summer program wrapped up with student presentations of the work completed during
each of their summer research sessions. Students were able to interact, learn and question the
diversity of research performed by each field incorporated in the summer program.
Subsequently students were presented with certificates and asked to provide feedback on this
year’s program.
9
The overall impression of the summer program was that it was very good. It provided an
enjoyable learning environment and an opportunity to interact with several students outside of
their lab. Each session was informative and well received. The major modification that was
suggested by the student body was to have the sessions spaced out once every week rather
than once every two weeks as done this year. We look forward to seeing this group as well as
some new faces next summer.
AWARDS
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This award,
established in 1995, helps to defray costs of travel for Program students presenting their
research work at recognized scientific meetings. Students supported by this award this
academic year were:
Fall 2007:
No applications received.
Spring 2008:
Rohit Sheshgiri, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao)
International Society for Heart & Lung Transplantation 28th Annual Meeting, Boston,
Massachusetts, April 2008.
“Soluble HLA-G is Negatively Associated With Allograft Rejection Following Heart
Transplantation”
Elissa Tepperman, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao)
International Society for Heart & Lung Transplantation 28th Annual Meeting, Boston,
Massachusetts, April 2008.
“The Effect of Calcineurin Inhibition on Vasomotor Function and Visfatin Expression”
Bigelow Book Prize
This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to
recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences.
Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific
integrity. The award is given in every year that a qualified student is identified. Qualifications
include sustained academic scientific excellence, innovative experimental approaches, original
discoveries and good scientific productivity. Some weight is given to work that has recognizable
clinical relevance, especially that which promises to improve patient care. The Bigelow Book
Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious
Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are
identified and the final decision is made by the Program Committee.
1995 – Dr. John S. Ikonomidis
1996 – Ms. Shona M. Torrance
1997 – Dr. Vivek Rao
1998 – Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
2000 – Dr. Michael Borger
2001 – Dr. Saeid Babaei
2002 – Mr. Wm. Jack Wallen
2003 – Dr. Paul W.M. Fedak
2004 – Dr. Nathalie Lapointe
2005 – Dr. Karim Bandali
2006 – Mr. Danny Ramzy
2007 – Ms. Patricia Rose
2008 – Dr. Mitesh Badiwala
10
L-R: Pixie Currie, Dr. Mitesh, Badiwala,
Dr. Carin Wittnich
A heart transplant is a priceless gift to a fortunate patient with end-stage heart failure.
Regrettably, transplanted hearts develop a diffuse vasculopathy that limits their longevity. Dr.
Badiwala is dedicated toward a career as a cardiac surgeon-scientist with an interest in
developing novel strategies to preserve endothelial function and prevent cardiac allograft
vasculopathy after heart transplantation. His PhD thesis focuses on evaluating novel
endothelial protective strategies in the context of immunosuppressive therapy, on preventing
neointimal hyperplasia after vascular injury. Dr. Badiwala is also defining the role of a novel
endothelial chemoattractant protein, EGFL7, on the vascular endothelial response to hypoxiareperfusion injury to determine whether it is a novel target for therapeutic intervention. His other
research interests include investigating novel cardiac and endothelial protection strategies
during donor heart preservation and cardiac transplantation.
Lorne Phenix Graduate Award
This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by
Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart
disease – which is still the #1 killer of both men and women in Canada. In addition, women who
have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes
that this award will serve to encourage trainees to pursue this area of research to address this
particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis
of research and academic excellence. The award consists of a cash prize and certificate and is
presented to the recipient at the Annual Student Research Day. Appropriate candidates are
identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This
award is presented at the Annual Student Research Day.
2001 – Wm. Jack Wallen
2002 – Wm. Jack Wallen
2003 – Shathiyah Kulandavelu
2004 – Rachel Mitchell
2005 – Nesime Askin
2006 – Danny Quaglietta
2007 – Emma O’Donnell
L-R: Ms. Kathryn Phenix, Emma
O’Donnell, Dr. Carin Wittnich
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Emma O’Donnell is a PhD candidate in the Department of Exercise Sciences at the University
of Toronto. Under the supervision of Dr. Jack Goodman and Dr. Paula Harvey, Emma’s thesis
work is looking at estrogenic mechanisms of cardiovascular regulation in estrogen deficient
premenopausal women.
Discordance between the known biology of estrogen and the results of clinical trials of
postmenopausal hormone therapy underscore the need to better characterize, in controlled
mechanistic studies, estrogens multiple actions in human health and disease. Exerciseassociated amenorrhea (EAA) is a common and reversible cause of estrogen deficiency in
premenopausal women thought to be due to energy deficiency. Importantly, premenopausal
women with EAA have estrogen deficiency similar to postmenopausal women and thus provide
a unique model for examining the cardiovascular effects of estrogen independent of the effects
of aging and the presence of other co-morbidities.
Emma's previous work has shown that the women with EAA have disordered regional blood
flow, blood pressure and heart rate when compared to exercising normally menstruating
women. Her research will go on to examine: 1) the effects of estrogen on vascular function and
oxidative stress, as well as neurohumoral mechanisms of vascular function and blood pressure
regulation; and 2) to compare these responses in women with EAA in an estrogen deplete and
replete environment. This will be achieved by testing women with EAA both before and after 4
weeks of transdermal estrogen therapy. Her work will also investigate whether estrogen
deficiency due to EAA obviates the widely recognized cardiovascular benefits of habitual
aerobic exercise and premenopausal status, and whether this might contribute to premature
development of a cardiovascular phenotype more typically seen in postmenopausal women.
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards that have resulted from the Ontario government’s
“matching” program. Under the program every dollar of donation received for student
assistance has been matched by the government as well as the university on a dollar-for-dollar
basis. The Cardiovascular Sciences Collaborative Program participates in this program. There
are two major conditions for all OSOTF awards; recipients must be Ontario residents and
demonstrate financial need. However, the Program has additional eligibility criteria that must be
adhered to, including excellence in science and academic performance. One competition is
held per academic year. The applications are handled centrally through the Office of the
Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are
sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand.
Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of
Medicine). Three applications were received for this competition. Unfortunately, two of the
applications were ineligible. This year’s recipient was Nesime Askin, PhD candidate,
Department of Physiology.
Ontario Graduate School Science and Technology (OGSST)
The OGSST program is designed to encourage excellence in graduate studies in science and
technology. The program is supported through funds provided by the Ministry of Training,
Colleges and Universities and by funds raised by the University of Toronto and the Heart &
Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto
who are pursuing cardiovascular/stroke research. Students must have maintained an overall Aaverage over the last two years of study at the post-secondary level and exhibit research
ability/potential, good communication skills and interpersonal/leadership abilities. The following
students were ranked and offered an award:
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Name
Mark David
Michael Sellan
Steven Gu
Erin Mueller
Cindy Yip
Joshua Bell
Charlene Reynolds
Alexandra Rowland
Jason Wasserman
Degree
MSc
MSc
PhD
PhD
PhD
PhD
PhD
PhD
PhD
Dept.
PSL
PSL
PSL
LMP
BME
IMS
IMS
IMS
PSL
Supervisor
P. Backx
P. Backx
S. Heximer
M. Husain
C. Simmons
A. Baker
W. McIlroy
S. Black
L. Schlicter
ADVERTISING MATERIAL
The CSCP maintains and updates its web site (www.cscp.utoronto.ca). Faculty information is
updated whenever we are notified of relevant changes. Collaborating departments are
encouraged to provide hypertext links to the CSCP on their web site.
ACKNOWLEDGEMENTS
The Cardiovascular Sciences Collaborative Program would like to thank the following sponsors
for their generous support: Heart & Stroke Foundation of Ontario, Medtronic Canada, Biovail
Pharmaceuticals Canada, Bristol-Myers Squibb Company, Aventis Pharma.
13
STUDENTS
Name
Supervisor
Degree
Department
I. Eser Adiguzel
Jenna Adleman
Nesime Askin
Mitesh Badiwala
Laura Banks
Jessica Bronsoiler
Gian-Marco Busato
Carlo Cifelli
Geoff de Couto
Katharine Currie
Talha Farid
Lara Gotha
Nazanin Hakimzadeh
Christy Hamilton
Melanie Henriques
Judith Hoefer
Sonya Hui
Jessica (Jackman) Prodger
Zobia Jawed
Galina Kichigina
Mila Kisilevsky
Shathiyah Kulandavelu
Shawn Lacombe
Michael Lekas
Jane MacIver
Vaska Micevski
Anton Mihic
Forough Mohammadzadeh
Mark Moon
Emma O’Donnell
Mark Ormiston
Maral Ouzounian
Kumar Perampaladas
Kieran Quinn
Tenille Ragoonanan
Andrew Ramadeen
Patricia Rose
Meghan Sauve
Mike Sellan
Rohit Sheshgiri
Alexandra Smith
Stjepan Soric
Carly Spragg
Luka Srejic
Renee Suen
Luke Tan
Elissa Tepperman
M. Bendeck
C. Hudson
C. Wittnich
V. Rao
J. Goodman
M. Hough
J. Goodman
S. Heximer
P. Liu
J. Goodman
K. Nanthakumar
B. Strauss
D. Courtman
M. Locke
H. Zhang
M. Husain
M. Husain
V. Rao
M. Letarte
G. Gross
C. Hudson
L. Adamson
S. Thomas
D. Stewart
V. Rao
D. Stewart
R. Tsushima
T. Parker
P. Liu
J. Goodman
D. Courtman
P. Liu
J. Parker
H. Zhang
G. Hare
P. Dorian
C. Hudson
D. Drucker
P. Backx
V. Rao
H. Leong-Poi
C. Wittnich
S. Thomas
W. Hutchison
D. Stewart
C. Wittnich
V. Rao
PhD
MSc
PhD
PhD
MSc
PhD
MSc
PhD
MSc
MSc
MSc
MSc
MaSc
MSc
MSc
MSc
MSc
MSc
MSc
MSc
MSc
PhD
MSc
PhD
PhD
PhD
MSc
PhD
MSc
PhD
PhD
PhD
MSc
MSc
MSc
PhD
PhD
MSc
MSc
MSc
MSc
MSc
MSc
MSc
PhD
MSc
MSc
LMP
IMS
PSL
IMS
EXS
IMS
EXS
PSL
PSL
EXS
IMS
IMS
BME
EXS
PSL
IMS
PSL
IMS
MBP
IMS
IMS
PSL
EXS
IMS
IMS
IMS (inactive status)
PSL
IMS
PSL
EXS
BME
IMS
PCL
PSL
PSL
PCL
IMS
IMS
PSL
IMS
IMS
PSL
EXS
PSL
IMS
PSL
IMS
14
Megan Thompson
Sam Tirgari
Albert Tsui
Laura Voicu
Michael Ward
Cindy Yip
Jeff Yoo
S. Mital
S. Heximer
G. Hare
D. Mazer/G. Hare
D. Stewart
C. Simmons
R-K. Li
MSc
MSc
MSc
MSc
PhD
PhD
MSc
IMS
PSL
PSL
IMS
IMS
BME
IMS
Convocated Students/Follow-Up
Kirsteen Burton, MSc, Public Health Sciences (Supervisor: Dr. G.
Tomlinson): A Comparison of the Efficacy of Radiotherapy Alone Versus
Ratiotherapy Combined with Embolization in the Obliteration of Brain
AVMS in Canadian Patients: A Propensity Score Approach”
(Radiology, McMaster University)
Adam M. Gwozdz, MSc, Institute of Medical Science (Supervisor: Dr.
M. Rand): “Platelet Procoagulant Surface Expression: Persistence and
Relation to Apoptosis”
(Medical School – University College London, UK)
Danny Ramzy, PhD, Institute of Medical Science (Supervisor: Dr. V.
Rao): “Endothelial Injury in Cardiac Transplantation: The Role of
Endothelin Antagonism and Protein Kinases”
(Cardiac Surgeon)
Note: Should discrepancy arise between total number of students enrolled and the number convocated, it can be
accounted for students that are incomplete or terminate graduate studies.
15
Awards and Honors
Jenna Adleman
Vision Health Research Training Grant, Medical Sciences
(Ophthalmology), York University
Open Fellowship Award, University of Toronto, Medical Sciences
(Ophthalmology)
Nesime Askin
Gonul Anginer Award
Mitesh Badiwala
Starr Medal, Faculty of Medicine, University of Toronto, 2008
Edward Christie Stevens Fellowship, Faculty of Medicine,
University of Toronto, 2008
Joseph M. West Family Memorial Fund Award, Faculty of
Medicine, University of Toronto, 2008
Bigelow Book Prize, Cardiovascular Sciences Collaborative
Program, University of Toronto, 2008
Wellesley Surgeons OGSST, 2007
Johnson & Johnson Medical Products Surgeon Scientist Program
Fellowship, 2007
Carlo Cifelli
Upstate New York Cardiac Electrophysiological Society – Gordon
K. Moe Young Investigator Award, 2008
HSRLCE Annual Cardiovascular Scientific Day Poster
Competition, 3rd Place, 2008
Dr. John Hepburn Award, 2008
CIHR Graduate Scholarship, Doctoral Award, 2007-10
Christy Hamilton
Bertha Rosenstadt Ontario Graduate Scholarship, 2007-08
Melanie Henriques
NSERC Scholarship, 2008-09
HSFO Studentship, 2008 (declined)
OGS, 2008 (declined)
Top Trainee Idea Proposal, Runner-Up, St. Michael’s Hospital
Research Centre, 2007
Federation of Portuguese Canadian Business and Professionals
Award, 2007
University of Toronto Fellowship, 2007-08
HSFO John D. Schultz Science Student Scholarship, 2007-08
Sonya Hui
HSRLCE Masters Studentship, 2008
Department of Physiology Fellowship, University of Toronto, 2007
Shawn Lacombe
Glenn H. Carter Fellowship, 2007
Deans Student Leadership Award, 2007
Jane MacIver
Graduate Fellowship, CIHR Strategic Training Program in
Regenerative Medicine, 2007-09
Anton Mihic
HSRLCE Studentship, 2007-08
Mark Moon
Department of Physiology, University of Toronto Fellowship, 2007
Vice-President, CSCP Student Association
16
Emma O’Donnell
CIHR: Institute of Gender and Health in partnership with the
Ontario Women’s Health Council, Doctoral Res Award, 2008-10
Glenn Carter Exercise Intervention and Disease Prevention
Fellowship, University of Toronto, 2008
Lorne Phenix Graduate Award, Cardiovascular Sciences
Collaborative Program, University of Toronto, 2008
Bertha Rosenstadt Ontario Graduate Student Award, 2007
Maral Ouzounian
Canadian Institute of Health Research Fellowship
Wilfred G. Bigelow Prize, Terrence Donnelly Day, Canadian
Cardiac Surgery Residents’ Research Day, 2008
Andrew Ramadeen
University of Toronto Entrance Fellowship, 2007-08
Meghan Sauvé
Banting and Best Diabetes Centre, Novo Nordisk Studentship,
2007-09
Samuel Lunenfeld Research Institute Fellowship, 2007-09
Alexandra Smith
Dean’s Honour List, Queen’s University, 2007
Stjepan Soric
Department of Physiology Fellowship, UofT
NSERC Postgraduate Scholarship
Carly Spragg
Track & Field Junior Development Program, Assistant Coach,
University of Toronto, 2005-07
Luka Srejic
Unilever/Lipton Graduate Fellowship in Neuroscience, 2007-08
Department of Physiology, Fellowship, UofT
Renée Suen
Bigelow Book Prize Nomination, CSCP, UofT, 2008
International Travel Award, 2007
Sam Tirgari
HSRLCE Studentship, 2008
Albert Tsui
CIHR Doctoral Research Award (3 yrs), 2008
Best Poster Award, Critical Care Medicine, 2007
A.C. Bryan Award for Best Poster, Shields Day, 2007
Laura Voicu
Ontario Graduate Scholarship, 2007-08
Mary H. Beatty Scholarship, 2008
University of Toronto Fellowship, 2007-09
Michael Ward
Finalist, Alan Wu Poster Competition, IMS Research Day, 2008
Best Young Investigator Poster, Canadian Society for Clinical
Investigation, Young Investigators Forum, 2007
Cindy Yip
Vasculata Student Travel Award, North American Vascular
Biology Organization (declined), 2007
University of Toronto IBBME Fellowship, 2007-08
Heart & Stroke Foundation OGSST 2007-08
17
Society for Physical Regulation in Biology and Medicine Travel
Award, 2008
A.D. Sobel, American Society of Investigative Pathology
Education Fund Scholar, 2008
Publications
Adiguzel E, Ahmad PJ, Franco C, Bendeck MP: Collagens in atherosclerosis and its
complications. Vasc Med, 2008;1-17.
Badiwala MV, Ross HJ, Rao V: An unusual and fatal complication of mechanical circulatory
support with a continuous flow assist device. N Engl J Med, 2007;357:936-7.
Chan CL, Ouzounian M, Lee DS, Liu P: Diastolic heart failure: Treatment based on
mechanisms. Perspect Cardiol, 2008;24(1):28-31.
Cifelli C, Rose RA, Hangjun Z, Voigtlaender-Bolz J, Bolz S-S, Backx PH, Heximer SP: RGS4
regulates parasympathetic signalling and heart rate control in the sinoatrial node. Circ Res,
2008;103(5):527-35.
Cifelli C, Boudreault L, Gong B, Bercier JP, Renaud JM: Contractile dysfunctions in KATP
channel deficient mouse FDB muscle during fatigue involves excessive depolarization and Ca2+
influx through L-type Ca2+ channels. Exp Physiol, 2008;93(10):1126-38.
Gu S, Tirgari S, Heximer S: The RGS2 gene product from a candidate hypertension allele
shows decreased plasma membrane association and inhibition of Gq. Mol Pharacol,
2008;73(4):1037-43. [Epub Jan 29, 2008]
Kisilevsky M, Hudson C, Mardimae A, Wong T, Fisher J: Concentration-dependent
vasoconstrictive effect of hyperoxia on hypercarbia-dilated retinal blood vessels. Microvasc Res,
2008;75:263-8
Lad VS, Rao V, Badiwala MV, Jackman J: Stem-cell therapy for ischaemic cardiomyopathy.
Indian Heart J, 2007;59:B133-42.
Laurent G, Moe G, Hu X, Leong-Poi H, Connelly K, So PP, Ramadeen A, et al: Experimental
studies of atrial fibrillation: comparison of two pacing models. Am J Physiol Heart Circ Physiol,
2008;294:H1206-15.
Laurent G, Moe G, Hu X, So PP, Ramadeen A, Leong-Poi H, et al: Simultaneous right
atrioventricular pacing: a novel model for the study of atrial remodeling and fibrillation in the
setting of heart failure. J Card Fail, 2008;14(3):254-62.
Li HL, Liu C, de Couto G, Ouzounian M, Sun M, et al: Curcumin prevents and reverses
cardiac hypertrophy. J Clin Invest, 2008;118(3):879-93.
Maekawa Y, Ouzounian M, Opavsky MA, Liu PP: Connecting the missing link between dilated
cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity. Circulation,
2007;115(1):5-8.
18
O’Donnell E, Harvey PJ, De Souza MJ: Relationships between vascular resistance and energy
deficiency, nutritional status and oxidative stress in oestrogen deficient physically active women.
Clin Endocrinol, August 2008. [E-publication ahead of print]
Ouzounian M, Hassan A, Johnstone DEJ, Cox J, HowlettJ: the effect of spironolactone use on
heart failure mortality: a population-based study. J Card Fail, 2007;13(3):165-9.
Ouzounian M, Lee DS, Liu PP: Cardiovascular biomarkers: a risky business. Curr Cardiovasc
Rep, 2007;1:177-9.
Ramzy D, Tumiati LC, Tepperman E, Sheshgiri R, Jackman J, Badiwala MV, Rao V: Dual
immunosuppression enhances vasomotor injury: interactive effect between endothelin-1 and
nitric oxide bioavailability. J Thorac Cardiovasc Surg, 2008;135:938-44.
Rennie MY, Whiteley KJ, Kulandavelu S, Adamson SL, Sled JG: 3D visualization and
quantification by microcomputed tomography of late gestational changes in the arterial and
venous feto-placental vasculature os the mouse. Placenta, 2007;28(8-9):833-40.
Rigamonti A, LcLaren AT, Mazer CD, Nix K, Ragoonanan T, et al: Storage of strain specific rat
blood limits cerebral tissue oxygen delivery during acute fluid resuscitation. Br J Anaesth,
2008;100:357-64.
Soric S, Belanger MP, Askin N, Wittnich C: Impact of femal sex hormones on liver tissue lactic
acidosis during ischemia. Transplantation, 2007;84(6):763-70.
Soric S, Belanger MP, Wittnich C: A method for decontamination of animals involved in
floodwater disasters. J Am Vet Med Assoc, 2008;232:364-70.
Sztajer H, Lemme A, Vilchez R, Schulz S, Geffers R, Yip CYY, Levesque CM, Cvitkovitch DG,
Wagner-Dobler I: Autoinducer-2 regulated genes in streptococcus mutans UA159 and global
metabolic effect of the luxS mutation. J Bacteriol, 2008;190(1):401-15.
Teoh H, Quan A, Nesher N, Lovren F, Wang G, Tirgari S, et al: Impaired endothelial function in
C-reactive protein overexpressing mice. Atherosclerosis, 2008. [Epub ahead of print]
Ward MR, Stewart DJ, Kutryk MJ: Stent and Non-Stent-Based Cell Therapy for Vascular
Disease. IN: Endothelial Biomedicine. (Ed: Aird WC), Cambridge University Press, 2007.
Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG: Inhibition of cholesterol
biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic
β-cells. Endocrinology, 2008;149(10):5136-45.
Yip CYY, Chen JH, Simmons CA: Engineering Substrate Mechanics to Regulate Cell
Response. IN: Micro- and Nanoengineering of the Cell Microenvironment: Technologies and
Applications. (Eds. Khademhossein A, et al), Artech House Publishing, Boston, MA, 2007.
19
CSCP STUDENT ASSOCIATION SPONSORED ACTIVITIES
Circulation Rounds
The CSCP Student Association organizes and runs this event which highlights the diverse
nature of research carried out by our faculty. These academic rounds rotate through the various
research sites at the University of Toronto and each event is hosted by a faculty member where
their research focus is the topic of the day. The goal of this event is to provide graduate
students, post-doctoral fellows, research associates, undergraduates and project/summer
students with the chance to develop an appreciation of the vast range of excellent research
being conducted in our widespread community.
The first Circulation Rounds for the 2007-2008 academic year was given by Dr. SteffenSebastian Bolz where he talked on “Light and Shadow - The Effects of Sphingosine-1Phosphate (S1P) in Terminal Arteries”. Dr. Bolz’ primary research interests lie in understanding
the mechanisms that control smooth muscle cell tone in terminal arteries, which is of
considerable importance, as it directly relates to the regulation of systemic blood pressure and
tissue perfusion. His lecture focused on the mechanisms of blood pressure regulation by
sphingosine-1-phosphate (S1P) in terminal arteries. Dr. Bolz previously identified the S1P
signaling pathway as a prominent regulator of vascular tone, and he currently investigates the
role of this pathway in several types of terminal arteries, including those isolated from skeletal
muscle, the mesentery, the cerebral circulation, and the inner ear. Dr. Bolz is an intriguing and
extremely entertaining speaker. It brought about plenty of discussion among the attendees, who
were particularly curious about the potential clinical applications of targeting the S1P pathways.
The second speaker was Dr. Bradley Strauss, the Reichmann Research Chair at the University
of Toronto and Sunnybrook Health Sciences Centre. As an interventional cardiologist, Dr.
Strauss’ research interests lie in the field of vascular biology and include chronic total
occlusions, restenosis, smooth muscle cell function, and experimental arterial response to
injury. The seminar, entitled “Researching Chronic Total Occlusions: Shedding Light on a Dark
Place”, began with an introduction to the practice of interventional cardiology and the difficulties
that many cardiologists face due to the limitations of current 2D imaging. Consequently, novel
coronary imaging techniques designed in response to this problem were described. The
seminar also included a discussion of Dr. Strauss’ research, including angiogenic therapy and
the use of collagenases to help treat patients with luminal occlusions. Many of the attendees
enjoyed the clinical relevance of the seminar.
The third speaker was Dr. Scott Heximer, Assistant Professor and Tier II Canada Research
Chair in Cardiovascular Pathology, where he talked on “Mind the GAP: The Role of RGS
Proteins in the Control of Cardiovascular Pathology”. Dr. Heximer’s research focuses on the
mechanisms by which cardiovascular tissues regulate hetero-trimeric G-protein signaling. His
talk defined the functions of an important class of G-protein regulatory proteins, called RGS
proteins, in the cardiovascular system. Dr. Heximer began by giving an overview of RGS
proteins and their general function as negative modulators of G-protein activity. He then
discussed his lab’s work elucidating the molecular mechanisms and cardiovascular implications
of different RGS proteins through the use of gene knock-outs and physiological measures.
Specifically, the Heximer lab has discovered a role for RGS2 in the control of blood pressure
and vasoconstriction, RGS4 in parasympathetic signaling and heart rate control and hopes to
clarify the cardiovascular role of RGS5. The seminar and following discussion were wellattended and received.
20
FACULTY
Faculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research
interests and contact information are available on the web site. Departmental affiliations listed
are those within the CSCP.
Name
Full
Departmental Affiliation(s)
Location
Lee Adamson
Khosrow Adeli
Peter Backx
Jaques Belik
Michelle Bendeck
Sandra Black
Douglas Bradley
Dina Brooks
BME/IMS/PSL
LMP
Medicine/PSL
IMS/PSL
LMP/Medicine
IMS
IMS/Medicine
REH
John Coles
Philip Connelly
David Courtman
Paul Dorian
Daniel Drucker
C. Ross Ethier
IMS/Surgery
LMP/Medicine
BME/Surgery
IMS/Medicine/PCL
IMS/LMP
BME
John Flanagan
John S. Floras
Christopher Forrest
Stephen Fremes
Eser Fuller-Thomson
Adria Giacca
Jack M. Goodman
Len S. Goodman
Avrum I. Gotlieb
Aleksander Hinek
David Hampson
Margaret Hough
Chris Hudson
Mansoor Husain
K. Wayne Johnston
Peter G. Kalman
Fred Keeley
B. Lowell Langille
Michelle Letarte
Gary F. Lewis
Ren-Ke Li
Peter Liu
Marius Locke
Peter McLaughlin
Alan Moody
David Naylor
IMS
IMS/Medicine
IMS/Surgery
IMS/Surgery
Social Work
PSL
EXS
EXS
LMP
IMS/LMP
Pharmaceutical Science
IMS
IMS
IMS/LMP/Medicine
BME/IMS/Surgery
IMS/Surgery
LMP
LMP
MBP
IMS/Medicine
IMS/LMP/Surgery
IMS/Medicine
EXS/CHL
IMS/Medicine
BME/IMS
IMS/Medicine/CHL/Surgery
Mount Sinai Hospital
Hospital for Sick Children
UofT – FitzGerald Bldg.
Hospital for Sick Children
UofT – MSB
Sunnybrook Health Centre
Toronto General Hospital
UofT – Rehabilitation
Science
Hospital for Sick Children
St. Michael’s Hospital
St. Michael’s Hospital
St. Michael’s Hospital
Mount Sinai Hospital
UofT – Mechanical
Engineering
Toronto Western Hospital
Mount Sinai Hospital
Hospital for Sick Children
Sunnybrook Health Centre
UofT
UofT - MSB
UofT - Physical Ed & Health
Def & Civil Inst Environ Med
Toronto General Hospital
Hospital for Sick Children
UofT – Pharmacy
Sunnybrook Health Centre
Toronto Western Hospital
Toronto General Hospital
Toronto General Hospital
Community
Hospital for Sick Children
Toronto General Hospital
Hospital for Sick Children
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
UofT – Physical Ed & Health
Toronto General Hospital
Sunnybrook Health Centre
UofT – MSB
21
Heyu Ni
Peter O’Brien
John Parker
Tom Parker
Margaret Rand
Vivek Rao
Michael Sefton
Craig Simmons
LMP
PHM
IMS/Medicine
IMS/Medicine
IMS/LMP
IMS/Surgery
BME
BME
Arthur S. Slutsky
David Steinman
Donna E. Stewart
Duncan Stewart
Bradley Strauss
Howard Tenenbaum
Scott G. Thomas
Jack Tu
Robert Wald
Richard D. Weisel
Peter Wells
Gregory Wilson
Carin Wittnich
Graham Wright
Shirley Wu
Burton Yang
Terry Yau
Erik L. Yeo
Yeni Yücel
Haibo Zhang
IMS/Medicine/Surgery
BME
Anesthesia/IMS/Surgery/Medicine
IMS/LMP/Medicine
LMP/Medicine
Dentistry
EXS/PSL
HPME
IMS/Medicine
IMS/Surgery
PHM
IMS/LMP/PSL/Surgery
IMS/PSL/Surgery
MBP
PHM
LMP
IMS/Surgery
IMS/Medicine
LMP
IMS/PSL
St. Michael’s Hospital
UofT - Pharmacy
Mount Sinai Hospital
Toronto General Hospital
Hospital for Sick Children
Toronto General Hospital
UofT – Wallberg Bldg.
UofT – Mechanical
Engineering
Mount Sinai Hospital
UofT – Wallberg Bldg.
Toronto General Hospital
St. Michael’s Hospital
St. Michael’s Hospital
UofT - Dentistry
UofT – Physical Ed & Health
Sunnybrook Health Centre
Mount Sinai Hospital
Toronto General Hospital
UofT - Pharmacy
Toronto General Hospital
UofT - MSB
Sunnybrook Health Centre
UofT - Pharmacy
Sunnybrook Health Centre
Toronto General Hospital
Toronto General Hospital
St. Michael’s Hospital
St. Michael’s Hospital
Anesthesia
IMS
PSL
PSL
PSL
CHL
IMS
LMP
IMS/Surgery
IMS
IMS
PSL
Toronto General Hospital
Hospital for Sick Children
St. Michael’s Hospital
UofT - MSB
Toronto Western Hospital
Toronto General Hospital
St. Michael’s Hospital
St. Michael’s Hospital
Toronto General Hospital
Hospital for Sick Children
Toronto General Hospital
UofT - MSB
LMP/Medicine
Surgery
Surgery
Anesthesia/IMS
Anesthesia
Toronto General Hospital
Sunnybrook Health Centre
Toronto General Hospital
St. Michael’s Hospital
Toronto General Hospital
Associate
Joel Fisher
Gil Gross
Gregory Hare
Scott Heximer
William Hutchison
Jane Irvine
Howard Leong-Poi
Valery Leytin
Tom Lindsay
Seema Mital
Kumar Nanthakumar
Steffen-Sebastian Bolz
Affiliate
Jagdish Butany
Gideon Cohen
Chris M. Feindel
David Mazer
Patricia Murphy
22
PEER REVIEWED FUNDING
Name
Adamson, L
Agency
CIHR-Maintenance
CIHR-Group
CIHR-Equip
/Maintenance
CIHR-Operating
CIHR-Operating
CIHR-Resource
CIHR-Operating
CIHR-Healthy
Pregnancy Program
CIHR-Group
HSFC-Grant-in-Aid
Belik, J
CIHR-Operating
CIHR-Group
HSFO-Operating
Black, SE
HSFO
CIHR
HSFO
NIH
HSFO
HSFC
CIHR
CIHR
NIH
CIHR
Alzheimer Society of
Canada
Ontario Stroke System
Ontario Mental Health
Foundation
PSI Foundation
Title
Maintenance of the advanced bioimaging centre (2006-11)
Development and fetal health (2005-10)
Cardiovascular phenotyping in embryonic and newborn mice
(2005-10)
Generation and physiological analysis of genome-wide
mutations in mice (2004-09)
Cardiovascular phenotyping in embryonic and newborn mice
(2004-08)
Canadian mouse mutant repository: a core resource for mouse
models of human disease (2006-11)
A murine model to investigate the mechanisms underlying
DOHαD (2006-09)
Fetal growth restriction: mechanisms and outcomes (2005-10)
Centre for modeling human disease (2004-09)
Three dimensional quantification of the placenta vascular tree:
relationship with normal and abnormal fetal growth and
hemodynamics (2006-08)
Airway modulation of pulmonary vascular tone during
development and following pulmonary hypertension (2004-09)
Group in lung development (2004-09)
Endothelial eNOS uncoupling and role of BMP-9 in the
regulation of pulmonary vascular tone during development and
following pulmonary hypertension (2007-09)
Neuropsychological profiles and neuroanatomic correlates of
limb apraxia (2007-12)
The language impairment in progressive aphasia: a longitudinal
neuropsychological and imaging study (2007-12)
Role of cytokine-serotonin interactions in post-stroke
depression and cognitive symptoms (2007-10)
Validation of the NINDS VCI neuropsychological protocols
(2007-10)
Role of cytokine-serotonin interactions in post-stroke
depression (2006-08
In vivo characterization of subcortical vascular cognitive
impairment using advanced high field MR techniques (2005-08)
In vivo brain mapping in the dementias: a longitudinal brainbehaviour study with a focus on cerebrovascular disease
(2003-08)
A multi-centre, blinded, randomized, controlled trial comparing
different regimens of the antibiotics doxycycline and rifampin
for treatment of Alzheimer’s Disease (DARAD) (2006-10)
ADNI (Alzheimer’s Disease Neuroimaging Initiative) (2005-09)
Canadian Alzheimer’s Disease quality of life study (2002-09)
Assessing driving performance in persons with mild cognitive
impairment and mild dementia (2008-10)
Infrastructure revision of the collaborative affect, cognition and
behavior database tool (ABC’s) (2007-08)
Theory of mind in Alzheimer’s Disease and frontotemporal
dementia (2007-09)
Relationship between neuropsychological deficits and
hippocampal volume in coronary artery disease (2007-09)
23
Name
Black, SE
(cont’d)
Agency
Bell Labs, UofT
CIHR
CIHR
HSFO
NSERC / CIHR
CIHR
Alzheimer Soc Canada
Can Stroke Network
CIHR Maintenance/
equipment grant
CIHR Program Grant
Brooks, D
NCR Can Stroke
Network
HSFO
Ont. Lung Assoc.
CIHR
CIHR
CIHR
Physicians Services
Inc.
Physiotherapy Fdnt/
Can. Lung Assoc.
Start-up Award
CIHR
Ont Research Fund/
Can Fdtn of Innovation
CIHR
Lung Association
Ontario Lung Assoc.
Ontario Lung Assoc.
Butany, J
Connelly, P
CIHR Team Grant
NSERC/CIHR/CHRP
HSFO
Title
Context-aware mobile devices and wireless services as
cognitive aids for senior citizens (2007-08)
Determinants of safe mobility in the elderly who use assistive
mobility devices (2007-08)
Parietal and temporal contributions to the neglect syndrome
(2006-09)
Feasibility and effects of cardiac rehabilitation for individuals
after stroke (2006-09)
Personal therapist: a smart ambulatory monitoring system to
facilitate recovery following stroke (2006-09)
Early exercise intervention after stroke: improving
cardiovascular health, functional capacity and sensorimotor
control (2006-09)
Function and behavioural and psychological symptoms of
frontotemporal dementia (2006-08)
Stroke Canada optimization of rehabilitation by evidence –
implementation trial (SCORE-IT) (2006-08)
Centre for research using magnetic resonance (2005-10)
Brain and aging group at the Rotman Research Institute (200308)
Canadian Stroke Registry (2001-08)
Cardiac rehabilitation for individuals after stroke (2006-09)
Evidence-based suctioning: A systematic review (2007-08)
The personal therapist: A smart ambulatory monitoring system
to facilitate recovery following stroke (2006-09)
Timely access and seamless transitions in rural palliative/end
of life care (2006-11)
Improving sensorimotor recovery, aerobic capacity and
functional walking (2006-09)
Investigating the relationships between measures of functional
exercise capacity, symptoms and physical activity during daily
life in subjects with COPD (2007-09)
Effects of course layout on 6-minute walk distance (6MWD) in
COPD: A prospective within subject study (2007-08)
Research aimed at muscle performance (2008-11)
Theatre-based intervention for increasing exercise participation
by older adults requiring chronic hemodialysis (2007-08)
Cardiopulmonary rehabilitation laboratory: Infrastructure to
generate knowledge to maximize daily function in individuals
with chronic obstructive pulmonary disease (2007-08)
Concensus Meeting: Quality indicators for end of life care in
COPD (2008)
Unsupported arm exercise and breathing strategies in patients
with COPD (2008-09)
Survey of suctioning practice in Ontario (2008-09)
The six-minute walk test: Responses in healthy Canadians
aged 45-85 years (2008-09)
Chronic total occlusion (2006-09)
Local tissue changes in dilated ascending aortas (2005-08)
Molecular mechanisms for oxidation of high density lipoproteins
(2006-08)
24
Name
Connelly, P
(cont’d)
Agency
HSFO
CIHR
Can Diabetes Assoc.
Dorian, P
Pfizer
HSFC
HSFC
CIHR
Can Stroke Network
Fisher, JA
CIHR
Floras, J
CIHR
HSFO
HSFO-Program
CIHR
CIHR
HSFO
CIHR
Giacca, A
HSFC
HSFC
CDA
CIHR
CIHR
CIHR
NSERC
NSERC
NSERC
Gotlieb, AI
HSFO
CIHR
HSFO
Title
Comparative studies of paraoxonase 1 and paraoxonase 3
(2005-08)
Role of adipokines and inflammatory proteins in the early
pathophysiology of type 2 diabetes in women with a history of
gestational diabetes (2007-12)
Role of adipokines and inflammatory proteins in the early
pathophysiology of type 2 diabetes in women with a history of
gestational diabetes (2007-10)
Nitrosation of apolipoprotein A1 (2007)
Drivers with implantable cardioverter defibrillators (ICDs) in
Ontario: database linkage feasibility – a pilot project (2008-10)
Improving teaching of basic life support: a randomized pilot
study of real-time feedback in CPR performance (2008-09)
Centre for global clinical trials – CANNeCTIN (2008-10)
Event monitoring belt for recording atrial fibrillation after a
cerebral ischemic event: a RCT (EMBRACE) (2008-10)
Multi-modal imaging studies of the relationship between age,
physical activity level, cerebral physiology, and cognitive
performance (2007-11)
CIHR Tier I Chair (2004- )
Career investigator Award (2001-09)
Multidisciplinary group for the investigation and therapy of
human cardiovascular disease (2003-08)
Cardiovascular, autonomic and neurohormonal impact of
nocturnal hemodialysis (2005-10)
Pathophysiology sleep apnea in heart & renal failure (2007-12)
Effects of continuous positive airway pressure on myocardial
energetics and sympathetic nerve function in patients with
heart failure and obstructive sleep apnea (2005-08)
Effects of HMG-co-A reductase inhibitor therapy on neural
control of the heart and circulation in human heart failure
(2007-08)
Anti-atherogenic effect of insulin (2005-08)
Vasculoprotectie effect of insuln in vivo (2008-11)
Mechanisms of fat-induced hepatic insulin resistance (2006-08)
Interaction between lipotoxicity and glucotoxicity on glucose
stimulated insulin secretion (2004-07)
Glucose toxicity: prevention of complications and preservation
of beta cell function (2002-07)
Mechanisms of oxidative stree-mediated beta cell glucotoxicity
and lipotoxicity in vivo (2007-12)
Investigation of the biological effects of the polyphenol
resveratrol on skeletal muscle glucose transport (2004-07)
MEMS-based closed loop drug delivery devices integrating
stimulus-responsive nanohydrogels: design, fabrication, and
testing (2007-10)
Investigation of the biological effects of the polyphenol
resveratrol on insulin producing and insulin target tissues
(2007-09)
Cell biology of atherosclerosis (2005-10)
The endothelium in atherogenesis: Influences of hemodynamic
stresses (2007-12)
Cell biology of heart valve interstitial cells (2007-09)
25
Name
Gramolini, A
Agency
HSFO
CIHR
Gross G
Can Fdtn for Innovation
CIHR
HSFO
HSFO
CIHR
HFSO
CIHR
Hinek, A
CIHR-Operating
HSFO-Operating
Human Matrix Sciences
HSFC
CIHR-Group
HSFC-Operating
HSFC-Operating
Hudson, C
Glaucoma Res. Society
CIHR-Operating
Husain, M
CIHR-Operating
HSFO-Operating
CIHR- Operating
CIHR-Operating
HSFO-Operating
CIHR-Operating
HSFO-Operating
CIHR-Operating
HSFO-Group
CIHR-Group
HSFO
CIHR
Title
Molecular basis of PLN regulation and function in cardiac
muscle (2006-08)
Molecular regulation and function of ryanodine receptors
(RyR1) in skeletal muscle (2007-12)
Cardiovascular proteomics & molecular theapeutics (2007-12)
Characterization of circulating effectors and temporal profiling
of remote ischaemic preconditioning (2006-09)
Ventricular repolarization in complete heart block (2004-07)
Contractile and electrophysiologic adaptations to constrained
heart rate conditions (2006-08)
Molecular expression and physiology in developing
atrioventricular nodal cells (2006-09)
Ventricular repolarization in bradycardic electrical remodeling
(2007-10)
Contractile adaptations to constrained heart rate conditions
(2008-12)
Elastin and elastin receptor in pathobiology of cardiovascular
disease (2006-11)
Elastin and elastin receptor in control of cellular proliferation
(2003-08)
Comparison of biological effects of different preparations of
elastin-derived peptides on skin fibroblasts (2004-10)
Career Investigator Award (2004-07)
Pathobiology of intimal plaques
Aldosterone receptor and non-receptor based mechanism of
repair and remodeling following cardiac injury (2005-08)
Elastin and elastin receptor as crucial factors modulating
cellular functions in cardiovascular development and disease
(2008-13)
Retinal vascular reactivity in response to isoxic hypercapnia in
primary open-angle glaucoma (2007-09)
Sight-threatening retinal complications in type 2 diabetes
(2005-10)
Vascular reactivity in primary open angle glaucoma (2006-10)
Role of glucagons-like peptides in cardiac health and disease
(2006-09)
c-Myb-dependent vascular smooth muscle cell proliferation
(2004-09)
The role of plasma membrane Ca2+-ATPase isoforms in
vascular smooth muscle cell biology (2003-08)
Controlling bioreactor condition to optimize regenerative
potential of cardiomyocytes (2007-09)
Pathophysiological relevance of endothelin-1 (2005-10)
Targeted over-expression of inducible NO synthase: relevance
for the pathogenesis of cardiovascular disease (2005-08)
Role of ACE2 in the regulation of cardiac and vascular function
(2003-08)
Cell biology of atherosclerosis (2005-10)
Determinants of host susceptibilities of heart failure (2003-08)
Molecular regulation of vascular smooth muscle cell
proliferation and contractility (2004-09)
Development of an anti-proliferative therapeutic that disrupts
CaM-cyclin E interactions (2007-08)
26
Name
Agency
Langille, L
CIHR-Operating
HSFO-Operating
HSFO-Operating
CIHR
Letarte, M
HSFO-Group
CIHR-Group
CIHR-Operating
HSF
CIHR-Operating
HSFO
United States Army
Leytin, V
HSFC
CIHR
Li, R-K
CIHR
Ont Min Agriculture and
Food/Univ. of Guelph
Food Res. Program
CIHR
CIHR
CIHR
HSFO
HSFO
HSFO
Can Fdnt for Innovation
CIHR
Lindsay, T
Physicians’ Services
Inc.
Mazer, CD
PSI
HSFO
Title
Influence of hemodynamics on arterial endothelium (2007-12)
Arterial responses to hemodynamic stresses (2007-10)
Cadherins and regulation of smooth muscle cell function (200712)
A new concept underlying the control of myometrial contractility
during pregnancy (2005-10)
Cell biology of atherosclerosis (2005-10)
Development and fetal health (2005-10)
Endoglin, ALK-1 and BMPRII networks: role in vascular
disorders (2005-10)
Role of endoglin in the normal vasculature and in the pathology
of hereditary hemorrhagic telangiectasia (2005-09)
Functional characterization of androgen-altered genes with a
putative role during early events in ovarian carcinogenesis
(2005-09)
eNOS uncoupling and role of bone morphogenetic protein in
the regulation of pulmonary vascular tone during development
and following pulmonary hypertension (2007-09)
Characterization of hereditary serous cancer precursors in
fallopian tube epithelium (2006-09)
Platelet apoptosis induced by chemical agonists and shear
stresses (2005-08)
Use of normal physiologic inhibitors of matrix metallopro-teinases to improve viability and function of platelet concentrates
(2006-09)
Autologous tissue-engineered grafts for congenital heart
surgery (2003-08)
Functionality of resistant starch and bioactive peptides in
preventing chronic diseases and promoting gut functions in
studies with the pig model (2004-08)
The interplay of recruited stem cells and the matrix after
myocardial infarction: shifting balance toward repair (2004-09)
The cardiac regeneration project: quantitative cell tracking and
response for cardiac regenerative approaches (CARE project)
(2006-11)
Inflammation, infection, trauma and repair cluster (2006-13)
Matrix modulation is required to restore cardiac function after
cell therapy (2007-09)
Peptide modified photocrosslinkable chitosan for cell therapy in
myocardial infarction (2007-10)
Restoration of cardiac function: cellular regeneration and matrix
reconstruction (2007-11)
The Regenerative Medicine Project (REMEDI) (2007-12)
An angiogenic progenitor cell niche in the uterus: potential
implications for cell therapy (2008-13)
Complement activation following ruptured abdominal aortic
aneurysm: combining human observation with animal
experimentation to establish a framework for human therapy
(2007-09)
High fidelity simulation versus traditional didactic seminars for
teaching trainees separation from cardiopulmonary bypass
(2006-08)
Unravelling the black box of adverse events in cardiac surgery
(2006-09)
27
Name
Mazer, CD
(cont’d)
Agency
PSI Foundation
AO Research Fund
CIHR
CIHR
Can Anesth Society
Can Blood Services
Soc Cardiovasc Anesth
IREF
Mital, S
Moody, A
NIH/NLHBI Pediatric
Heart Network
NIH/NLHBI Pediatric
Heart Network
Research Endowment
Labatt Family Heart Ctr
Innovation Funds
Labatt Family Heart Ctr
Innovation Funds
CIHR-Team
MRI
CIHR-Operating
CIHR-Team
CIHR-Operating
Pfizer Global Res/Dev
CIHR
CIHR
Ont Ministry of Health
Ni, H
CIHR
CIHR-Cdn Blood
Services
CIHR/Cdn Blood
Services
Title
Genetic biomarkers of renal injury after cardiopulmonary
bypass and anemia in the rat (2007-08)
Sternal closure stability using the sternal fixation system (200708)
Does nutrient supplementation influence cardiac function,
structure and survival by altering energy metabolism? (200507)
Blood conservation using antifibrinolytics: a randomized trial in
a cardiac surgery population – the BART study (2002-08)
Renal gene expression following cardiopulmonary bypass and
anemia in the rat (2006-07)
Transfusion triggers in cardiac surgery (2006-08)
Impact of cardiopulmonary bypass and cardiac surgery on
lymphocyte energetics and immune function in patients with
non insulin dependent diabetes mellitus (2005-07)
Clinical outcomes and predictors of prolonged length of stay in
the intensive care unit after cardiac surgery. Analysis from the
multicenter EPI 2 study (2006-08)
Genetic polymorphisms in pediatric cardiomyopathy (2006-11)
Single ventricle reconstruction-2 trial (2006-11)
Developmental biology and congenital heart research (2007)
Genetics of heart disease in children (2007-10)
VEGF signaling in HLHS (2007-2008)
Canadian atherosclerosis imaging network (CAIN) (2008-13)
Imaging for cardiovascular therapeutics (2008-13)
Magnetic resonance imaging for ischemia (2005-10)
CIHR team in occlusive vascular disease (2007-09)
The development of an in vivo animal model and non-invasive
high resolution imaging techniques for the study of
atherosclerotic intraplaque haemorrhage (2006-09)
A methodology study to investigate MRDTI for assessment of
lesion response to standard treatment in endometriosis (200709)
In vivo detection of early diabetic vessel wall disease – a
possible role for the RAGE-AGE RBC-Endothelial (RARE)
complex at the micro- and macrovascular levels (2007-09)
PROTECT: Prophylaxis for thromboenbolism in critical care
trial (2005-09)
The Ontario multidetector computed tomography (MDCT)
coronary angiography study (OMCAS) (2006-08)
Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanism of action of IVIG in a novel mouse
model (2007-11)
Investigation of pathogenesis of immune thrombocytopenia and
efficacy and mechanism of action of intravenous IgG (OVOG)
(2006-09)
Mechanism of action of IVIG in a murine model of fetal and
neonatal alloimmune thrombocytopenia: role of neonatal Fc
receptor (FcRn) (2007-09)
28
Name
Parker, T
Agency
CIHR
CIHR
HSFO
CIHR
CIHR-Team
HSFC
Rand, M
HSFO
Sefton, M
ORDCF
CIHR
NSERC
CIHR
CIHR
CIHR STIHR Program
CFI
NIH
Simmons, C
CIHR
NSERC-CIHR
NSERC-Discovery
CFI-ORF
CRC
Ont Early Researcher
AAOF Center
HSF
HSF
NSERC RTI
NSERC RTI
CIHR
Slutsky, AS
Ont. Res Comm Prog
CIHR
CIHR/HSFC
Stewart, DE
Ont Min Health Long
and Term Care
CIHR
CIHR
Title
Role of S100B-dependent pathways in the cardiac response to
disease (2005-10)
EF-hand proteins, S100A1 and S100A6, in cardiovascular
pathophysiology (2007-09)
EF-hand proteins, S100A1 and S100A6, in cardiovascular
pathophysiology (2008-13)
Coordinated original research in elucidation of mechanisms in
heart failure (CORE-CHF) (2003-08)
Dysfunctional endothelial cell repair in diabetes: pathogenetic
mechanisms and regenerative strategies (2006-11)
Endothelial progenitor cell modification to improve left
ventricular function post myocardial infarction (2008-11)
Procoagulant surface of activated platelets: Persistence in vivo
and in vitro
Establishment of an advanced reconstructive tissue
engineering centre (2003-09)
Tissue engineering: Immune response and vascularisation
(2004-07)
Tissue engineering (2008-13)
Training program in regenerative medicine (2002-08)
Quantum dot-based biomolecular imaging (2005-10)
The cardiac regeneration (CARE) project (2006-11)
The regenerative medicine (REMEDI) project (2006-11)
Modular tissue engineering components for vascularized 3-D
constructs (2007-10)
Modular tissue engineering for islet transplantation (2007-08)
Investigation of mesenchymal progenitor cell response to
mechanobiological stimuli using a novel MEMS-based array
platform (2006-09)
Heart valve cell biomechanics and mechanobiology (2006-11)
IMchanobiology lab (2006-09)
Canadian Research Chair in mechanobiology (2006-11)
Tissue engineered heart valves (2006-11)
3D model to study orthodontic tooth movement (2007-08)
ECM biomechanics in aortic valve sclerosis (2007-08)
Myofibroblast mechanoregulation (2007-10)
Non-contact plotter for precise patterning of proteins on novel
microdevices (2008-09)
A polscope for non-invasive visualization of meiotic spindle
(2008-09)
Multi-user equipment for molecular and cell biological analysis
(2006-11)
Bioreactor for urinary bladder regeneration (2008-09)
Biotrauma: mechanisms of lung injury and distal organ
dysfunction (2004-09)
Clinical research consortium to improve resuscitation
outcomes: from bench to bedside to curbside (2004-09)
Improving health and promoting equity for the women of
Ontario (2006-09)
International comparisons of the perinatal health and care of
migrant women (2006-08)
Cardiovascular secondary prevention for vulnerable
populations: an interdisciplinary approach to improving access
to services and outcomes (2006-11)
29
Name
Stewart, DE
(cont’d)
Agency
CIHR
CIHR
CIHR
Int Dev Res Centre
Public Health Agency
CIHR
Can Diabetes Assoc.
CIHR
CIHR
CIHR
CIHR
Tu, J
HSFO
HSFO
CIHR
CIHR
CIHR
CIHR
CIHR
CIHR
CIHR
Ministry of Health
CIHR
HSFO
CIHR
WattWatson, J
CIHR
CAN
CAN
CIHR/HSFC
Title
Assessing the feasibility to measure and compare gendersensitive mental health indicators in Peru, Colombia and
Canada (2006-08)
Neurochemical aspects of depression in women: monoamine
oxidase A in the postpartum period (2007-10)
Measuring and understanding gender equity in access to care
(2006-09)
Political violence, natural disasters and mental health
outcomes: developing innovative health policies and
interventions (2007-11)
Health indicator research (2006-08)
Comparing paper vs electronic transmission of cardiac
rehabilitation summaries to primary care physicians: a multi-site
multi-method study of information flow and content (the
CR2DoC study) (2008-11)
Food insecurity in Canadians with diabetes mellitus (2007-08)
Mood changes and daily life (2005-08)
The childbearing health and related service needs of
newcomers (CHARSNN) (2004-08)
An RCT to evaluate the effectiveness of peer support for PPD
(2004-08)
Contribution of patient and physician factors to cardiac
rehabilitation referral and participation: a prospective, multilevel study (2005-08)
Drivers with implantable cardioverter defibrillators (ICDs) in
Ontario: database linkage feasibility: a pilot project (2008-10)
Indicators of quality stroke care associated with clinical
outcomes (2008-10)
Emergent care and outcomes of acute heart failure (2008-10)
Statistical methods for health services research (2008-10)
A population-based analysis of the effectiveness and adverse
effects of medications in patients with atrial fibrillation (2007-10)
Evaluating and improving the quality of care and outcomes of
percutaneous coronary interventions in Canada (2007-09)
Canada Research Chair in Health Services Tier 1 (2007-13)
Care gaps among high-risk cardiovascular patients: Evaluating
the inappropriateness and clinical significance of the “treatment
–risk paradox” (2006-09)
Access to quality cardiac care (2006-11)
The Ontario implantable cardioverter defibrillator (2006-11)
Canada Research Chair in Health Services Tier 2 (2006-08)
Improving the quality of acute myocardial infarction care in
Canada (2005-10)
Gender and sex determinants of cardiovascular disease: from
bench to beyond (2004-09)
Prevalence and predictors of non-ischemic chest pain following
successful percutaneous coronary intervention (2007-08)
How do providers manage pain in hip fracture patients after
they are educated about the RNAO best practice guidelines
(2007-08)
Concept analysis and feasibility study of an adapted non-verbal
pain assessment tool (2007-08)
Training program for cardiovascular nurse scientists (2003-09)
30
Name
Weisel, RD
Wells, PG
Agency
HSF
CIHR
CFI & ORS
HSF
Methanol Fdtn (USA)
CIHR
CIHR
Wittnich, C
Wright, GA
NIH
HSFO
HSFO
CIHR-Operating
Ont Innovation Trust
CIHR
CIHR
CIHR
CIHR-Operating
CIHR
Cdn Fdtn Innovation
Cdn Fdtn Innovation
Ont Research Fund
Ont Research Commercialization Program
CIHR-Operating
NSERC
Wu, S
Yang, B
CHRP-Operating
NSERC
BioDiscovery Toronto
CIHR
HSFO
Yau, T
CIHR
Yücel, YH
Glaucoma Res Society
Int Glaucoma Review
CIHR
Can Glaucoma Clinical
Research Council
Guacoma Res Society
Title
Cardiac regeneration by cell transplantation (2006-09)
The cardiac regeneration project: Quantitative cell tracking and
response for cardiac regenerative approaches (CARE project)
(2007-11)
The regenerative medicine (REMEDI) project (2006-10)
Cardiac regeneration: improving response to injury(2007-10)
Molecular basis of methanol developmental toxicity (2006-10)
Toxicology of drugs bioactivated to a reactive intermediate
(2007-12)
Free radical determinants of meurodegenerative diseases
(2005-10)
Fetal DNA oxidation and repair in neurodegeneration (2006-08)
Oxygen stress in newborn hearts (2003-07)
Impact of gender on myocardial pathology & ischemia
reperfusion (2004-08)
Magnetic resonance imaging ischemic heart disease (2003-10)
Imaging research centre for cardiac intervention (2002-08)
Microvessel formation in chronic total occlusions:
pathophysiology and role in successful guide-wire crossing
(2005-08)
Centre for research using magnetic resonance (2005-10)
Magnetic resonance imaging for ischemia (2005-10)
Development of an in vivo animal model and non-invasive high
resolution imaging techniques for the study of atherosclerotic
intraplaque haemorrhage (2006-09)
CIHR team in occlusive vascular disease (2007-10)
Biomedical multimodality hybrid imaging (2007-11)
Regenerative medicine project (REMEDI) (2007-11)
Imaging for cardiovascular therapeutics (2007-13)
Bi-directional 3D assistive tool for medical image acquisition
and visualization (2008)
Therapeutic strategies for chronic total occlusion
revascularization (2008-11)
Forward-viewing Doppler optical coherence tomography with
artifical muscle actuation for interventional intravascular
imaging (2006-09)
(2007-10)
(2008-13)
(2008)
IGH Mid-Career Award – denied (2006-11)
Roles of miR-17-5p in endothelial wounding healing and
angiogenesis (2008-11)
Predictors of massive blood loss in cardiac surgery: value of
intraoperative coagulation testing (2006-08)
A new lymphatic outflow pathway as a novel target for
glaucoma treatment (2008-09)
Best Article Award 2006 (2007-08)
An outflow perspective on aqueous humor exit from the eye:
implications for glaucoma (2007-08)
Multifocal ERG in patients with glaucoma (2007-08)
Can a vaccine for multiple sclerosis prevent glaucoma injury in
the central visual system? (2007-08)
31
AWARDS AND HONORS
NAME
Black, SE
Brooks, D
Butany, J
Gotlieb, AI
Gramolini, A
Gross, G
Hudson, C
Husain, M
Leytin, V
Li, R-K
Lindsay, T
Mital, S
Rand, M
Sefton, MV
Stewart, DE
Wittnich, C
Wu, XY
Yücel, YH
HONORS AND AWARDS
- Practice-based Research Award, Sunnybrook Health Sciences Centre (2007-09)
- Deborah Ivy Christiani Brill Chair in Neurology, Sunnybrook Foundation, UofT
- SRI Merit Pool Award, Sunnybrook Research Institute
- Canada Research Chair – Tier 2 (2007-12)
- President, International Society for Cardiovascular Pathology (2007-09)
- President, Canadian Association of Pathologists (2006-09)
- Invited Guest Co-Editor, Seminars in Diagnostic Pathology: Issue on Cardiac Tumors.
Published (2008)
- William Boyd Lectureship, Canadian Association of Pathology
- Canada Research Chair Tier 2 (2007-12)
- New Investigator Award, Heart & Stroke Foundation of Canada (2006-11)
- Schwartz-Reisman Visiting SickKids Scholarship, Hospital for Sick Children, 2008
- Promoted to Professor (both UW and UofT)
- Career Investigator Award, Heart & Stroke Foundation of Ontario (2004-09)
- Associate Professor, Dept. of Laboratory Medicine and Pathobiology, UofT
- Canada Research Chair in Cardiac Regeneration, Tier 1
- Career Investigator Award, HSFC
- Vincenzo Panagia Distinguished Lecture Award
- Promotion to Professor, University of Toronto
- Wightman Berris Academy, Individual Teaching Award, 2008
- Roma and Marvin Auerbach Professor of developmental biology and congenital heart
disease research, 2007
- Member, Board of Directors, Heart and Stroke Foundation of Ontario
- Killam Prize, Canada Council for the Arts
- Founders Award, Society for Biomaterials, USA
- Hall of Distinction, UofT, Faculty of Applied Science & Engineering
- CIHR/Royal Society of Canada Visiting Women Scientist to Japan (WiSET)
- Co-Chair, International Committee to Review Abuses of Psychiatry, World Psychiatric
Association (2006-12)
- Inaugural Honorary Fellow, Canadian Psychiatric Association (2006-Present)
- Elected to AOA, Faculty Member (2006-Present)
- Institutional Advisory Board of CIHR Institute of Gender and Health (2006-09)
- Senior Advisor to World Health Organization on Women’s Mental Health (2007-Present)
- Commission on the Status of Women of the United Nationa (2005-Present)
- University Professor (2004-Present)
- President, International Association of Women’s Mental Health (2004-08)
- Excellence in undergraduate teaching, Life Sciences Award, UofT, 2008
- Provincial Innovation Award, Ontario Research & Commercialization Program, 2008
- American Academy of Opthalmology. Tau Pathology in Human Glaucomas, Top 10
paper, 2007
- American Glaucoma Society. Tau Pathology in Human Glaucomas, Top 10 paper, 2007
- Nominee, Lewis Rudin Glaucoma Prize, 2007
- Global Association of International Glaucoma Societies Award, 2007
32
PUBLICATIONS
Abdekhodaie MJ, Wu XY: Drug release from ion-exchange microspheres: mathematical
modeling and experimental verification. Biomaterials, 2008;29:1654-63. (Web publication:
doi:10.1016/j.biomaterials.2007.11.044)
Abdel-Malek N, Chiarelli AM, Sloan M, Stewart DE, Mai V, Howlett RI: Influence of physician
and patient characteristics on adherence to breast cancer screening recommendations. Eur J
Cancer Prev, 2008;17(1):48-53.
Ahmad F, Hogg-Johnson S, Stewart DE, Levinson W: Violence involving intimate partners:
prevalence in Canadian family practice. Can Fam Physician, 2007;53:460-8.
Ahmad K, Dorian P: Drug-induced QT prolongation and proarrhythmia: An inevitable link?
Europace, 2007;9:iv16-22.
Al-Attar SA, Pollex RL, Ban MR, Young TK,… Connelly PW, Huff MW, Hegele RA: Association
between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian
multi-ethnic sample. Cardiovasc Diabetol, 2008;7:5. doi:10.1186/1475-2840-7-5
Al-Kwifi O, Wright GA: Comparing the limits of 3D contrast enhanced MRA at 1.5 and 3T to
achieve high spatial resolution. Neurosci Imaging, 2007;2(2):91-9.
Al-Kwifi O, Wright GA: Rapid estimation of motion blur for real-time optimization of high
resolution imaging. Neurosci Imaging, 2007;2(2):101-6.
Altaf N, Beech A, Goode SD, Gladman JR, Moody AR, Auer DP, Macsweeney ST: Carotid
intraplaque hemorrhage detected by magnetic resonance imaging predicts embolization during
carotid endarterectomy. J Vasc Surg, 2007;46(1):31-6.
Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, Moody AR, Gladman JR: Detection
of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to
moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg, 2008;47(2):33742.
Amfilochiadis AA, Backx PH, Floras JS: Adrenomedullary catecholamine, pressor and
chronotropic responses to human coagulation β-FXIIa mediated by endogenous kinins. J
Hypertens, 2008;26:61-9.
Aufderheide TP, Kudenchuk PJ, Hedges JR, Nichol G, Kerber RE, Dorian P, Davis DP,… for
the ROC Investigators: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial
methods, Part 1: rationale and methodology for the impedance threshold device (ITD) protocol.
Resuscitation, 2008;78(2):179-185.
Baker JE, Mazer CD: Anticoagulation and regional anesthesia in cardiac surgery: safety
considerations. Tech Reg Anesth Pain Manag, 2008;12(1):17-25.
Baker AJ, Park E, Hare GMT, Liu E, Sikich N, Mazer CD: Effects of resuscitation fluid on
neurological physiology after cerebral trauma and hemorrhage. J Trauma, 2008;64(2):348-57.
33
Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M: Cardioprotective and
vasodilatory actions of GLP-1 are mediated through both GLP-1 receptor-dependent and
independent pathways. Circulation, 2008;117(18):2340-50. [Epub 2008 Apr 21]
Bansal V, Hill K, Dolmage TE, Brooks D, Woon LJ, Goldstein RS: Modifying track layout from
straight to circular has a modest effect on the six-minute walk distance. Chest, 2008,133:115560.
Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, Smith W, Dorian P, et al, for the
HAT Investigators: Rationale and design of the Home Automatic external defibrillator Trial
(HAT). Am Heart J, 2008;155(3):445-54.
Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, Smith W, Dorian P, et al, for the
HAT Investigators: Home use of automated external defibrillators for sudden cardiac arrest. N
Engl J Med, 2008;358(17):1793-804.
Bauwens CL, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M, Zandstra
PW: Control of human embryonic stem cell colony and aggregate size heterogeneity
influences differentiation trajectories. Stem Cells, 2008 June 26. [Epub ahead of print]
Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS, Sinderby C: Non-invasive nurally
adjusted ventilatory assist in rabbits with acute lung injury. Intensive Care Med, 2008;34(2):31623.
Behrmann M, Avidan G, Gao FQ, Black S: Structural imaging reveals anatomical alterations in
inferotemporal cortex in congenital prosopagnosia. Cereb Cortex, 2007;17:2354-63.
Belik J, Shehnaz D, Pan J, Grasemann H: Developmental changes in arginase expression and
activity in the lung. Am J Physiol Lung Cell Mol Physiol, 2008;294:L498-504.
Bergman B, Ahmad F, Stewart DE: Work family balance, stress and salivary cortisol in men
and women academic physicians. Int J Behav Med, 2008;15(1):54-61.
Bernstein D, Williams GE, Eisen H, Mital S, Wohlgemuth JG, Klingler TM, Fang KC,
Kobashigawa J: Gene expression profiling distinguishes a molecular signature for grade 1B
mild acute cellular rejection in cardiac allograft recipients. J Heart Lung Transplant,
2007;26(12):1270-80.
Best G, Dennis M, Hudson C, Lee R and Smit H: Optometric care of the patient with diabetes a core document of the Canadian Association of Optometrists. Can Assoc Optometrists, 2008
(http://portal.opto.ca/committees-administration/cao-committees/diabetes-committee/).
Black SE, Doody R, Li H, McRae T, et al: Donepezil preserves cognition and global function in
patients with Alzheimer Disease. Neurology, 2007;69(5):459-69
Black SE: PiB PET and cerebral amyloid angiopathy detection. J Watch Neurol, 2008, Review.
Blackmore ER, Munce SE, Weller I, Zagorski BM, Stansfeld SA, Stewart DE, Cain ED, Conwell
Y: Psychosocial and clinical correlates of suicidal acts: results from a national population
survey. Brit J of Psychiatry, 2008;192:279-84.
34
Blackmore ER, Stansfeld SA, Weller I, Munce SE, Zagorski BM, Stewart DE: Major depressive
episodes and work stress: results from a national population survey. Am J Public Health,
2007;97:2088-93.
Blair M, Kertesz A, Davis-Faroque N, Hsiung GY, Black SE, et al: Behavioural measures in
frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural
inventory and the neuropsychiatric inventory in a national cohort study. Dement Geriatr Cogn
Disord, 2007;23(6):406-15.
Bocti C, Black S, Frank C: Management of dementia with a cerebrovascular component.
Alzheimer’s and Dementia, 2007;3(4):398-403.
Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS, et al: Twenty-year experience with heart
transplantation for infants and children with restrictive cardiomyopathy: 1986-2006. Am J
Transplant, 2008;8:201-7.
Bouchentouf M, Benabdallah BF, Bigey P, Yau TM, Tremblay JP: Vascular endothelial growth
factor reduced hypoxia induced death of human myoblasts and improved their engraftment in
SCID mouse muscles. Gene Ther, 2007;15:404-14.
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