Veterinary Program at University Health Network, Toronto
CCAC Workshop
Montreal
November 1, 2007
1
The Research Hospital: Inspire. Innovate. Impact.
Veterinary Program at
University Health Network
Toronto
CCAC Workshop
Montreal
November 1, 2007
ARC, UHN
PMH-R
MaRS-MS
STTARR
CBS-M
MBG-MS
MBB-M
TWG-MS
UHN Programs
• PROGRAMS
• PRIORITY TECHNOLOGIES
• Advanced Medicine &
Surgery
• Community & Patient Health
• Heart & Circulation
• Musculoskeletal Health &
Arthritis
• Neural & Sensory Sciences
• Oncology & Blood Disorders
• Transplantation
• Genomics/Proteomics &
Patients ~ Genes, Protein &
People
• Clinical Informatics ~ Health
Informatics
• Regenerative Medicine ~
Regenerative Medicine
• Advanced Clinical
Technologies ~ Medical
Technology Innovations
UHN RESEARCH:
SIZE AND SCOPE 2006
Research Space 637,000 sq ft
Publications 1284
Total Funding $189,257,000
150 - 200 PIs
20K mouse cages
1+K rat cages
Large animal models
Staff and Students (excludes Senior
Scientists 156
Scientists 51
Affiliate Scientists 49
CSRC/CRU Members 222
Total Researchers 478
Fellows 430
Graduate Students 368
Total Trainees 798
Technical and Support Staff 1170
HR component 60-65 FTP
Includes 2 vets
Veterinary Care Program
•
Objectives
– Moral & ethical obligations
• Well being of the animal model
– Regulatory & Institutional requirements
– Integrity and validated data from the animal model
• Phenotype & study
• Induced model, care & humane endpoints Vs Experimental timelines
•
Stakeholders
– Animal
– Investigators & Lab staff
– Animal care staff
– Institution
– Community
– Members of the Public
•
Integration
– Animal Care program
– Study protocol
•
Responsibility of a Veterinarian – CALAM Statement on Adequate
Veterinary Care, CCAC, ARA, Other
Veterinary Program
• Animal Care Committee
•
•
•
•
•
–
–
–
–
–
Pre-study
Pre-screening
Review
Pilots
Support & oversight
Clinical cases
Anaesthesia & Analgesia
Surgery – Rodent & LA models
Imaging modalities
Alternatives
Veterinary Program
• Health status
– Recognised commercial suppliers
– Non-commercial imports; Industrial partnerships; Other
Institutions
– Quarantine
• Laboratory diagnostics
–
–
–
–
–
–
–
Hospital laboratories
RADIL ~ value added [AALAS]; Charles River Labs
University of Guelph & Animal Health Laboratory
Bio-Reliance
Georgia State University
Vita-Tech
In house
• iStat
• Cultures
Veterinary Program
•
•
•
•
•
•
•
•
Regulations, Policies & Guidelines + CS
Standard Operating Procedures
Policy development
Animal care program
Training
Biosafety
Technical Services
Facility design, renovations, new buildings
– New technology
– Literature
– Publications
stakeholder
1
Principal
Investigator
Presubmission
meeting
+
2
AUPF
C
4
Vet prescreening
A&B
3
Animal Care
Committee
Admin
ACC SubCommittee
5
Animal Care Committee
Interim
Approval
20
Approved
Provisional
Not Approved
Clarification
requested
Not approved
Pilot
+ support
Pre-study
meeting
VP
Research
6
Limited or
Full Animal
Model Use
+/- CEO for
VP Research
Modification
Not Approved
Animal
Ordering
Census
Month
End
Billing
1
Principal
Investigator
Presubmission
meeting
+
2
AUPF
C
4
Vet prescreening
A&B
3
Animal Care
Committee
Admin
ACC SubCommittee
5
Animal Care Committee
Interim
Approval
Approved
Provisional
Not Approved
Clarification
requested
Pilot
+ support
Not approved
5
Animal Care Committee
Approved
Provisional
Pilot
+ support
Not Approved
Clarification
requested
Not approved
Pre-study
meeting
VP
Research
6
Limited
or
Full Animal
Model Use
+/- CEO for
VP Research
Modification
Not Approved
Emergency
Page/call Vet
Page/call lab
TDx, Dx
Tx, Rx
Open # case report
Case # on cage card
Sick Case
Site visits
Non-Emergency
AA/Lab Flags cage card
Advise AHT/Supv
Veterinary
Examination:
A
Consultative
Process
AHT Exam + data
On-line AUP
Open # case report
History;
Information from
Staff
Case # on cage card
+ Mtg with PI/lab
TDx, Dx
Page/call Vet
+ Advise Lab
Track
Tx, Rx
Euthanasia
Necropsy + Histo
Euthanasia
Closed case
Necropsy + Histo
TREATMENT CARD
Case #
Investigator
Date:
Problem:
TREAT with:
Date
Initials
Date
Initials
Treatment
Sheet
In
Medical
Cases
Binder
Weekly
Case
Master
Sheet
Shared
Online
File
Updated
“Daily”
By Site
Supv
Training
• Critical component
• Animal Care Short Course
– CCAC modules
• #s to date
– Institutional focus
–
–
–
–
–
• Critical areas
Species specific wet lab module
Facility Orientation
Mentoring
Support
Oversight
Common Problems in Mice
and Rats
Finding and reporting sick