Autumn 2013
News from the Florey Institute
of Neuroscience & Mental Health
A winning
combination
florey.edu.au
Director’s message
Dear friends of the Florey,
Welcome to a new look Brain
Matters and, to supporters of the
former Mental Health Research
Institute, a warm acknowledgement
of your interest and commitment
to brain and mind health.
As the Florey grows, we thought it was time we called on friends
to help us prepare for the future and to design a new look for
our amalgamated institute. Sincere thanks to the team at Emery
Design for their generous support
of the Florey and the beautiful new logo that will represent us
with a degree of gravitas for years to come.
The cover of this edition says a lot about the Florey right
now. Join us as we celebrate the career advancement of our
young researchers who are so ably mentored by our senior
neuroscientists. Awards provide a regular reminder of our place
in the international world of neuroscience – as do the number
of times our scientific publications are cited by colleagues
around the globe. I am pleased to report to you, our supporters,
that the Florey is now the third most cited neuroscience institute
internationally, a stunning achievement given our geographical
position and the constant struggle for funding.
You may have seen some media recently when I joined
with colleagues from the University of Melbourne (Prof Jim
McCluskey) and the Walter and Eliza Hall Institute (Prof Doug
Hilton) to call on the Federal Minister of Health, Tanya Plibersek,
to release and commit to the Strategic Review of Health and
Medical Research in Australia. At the time of going to press,
we are still waiting for Simon McKeon’s 15-month review to be
released. It was delivered to the Minister on February 28. Both
sides of politics will need to embrace medical research as a key
election issue and commit to Mr McKeon’s 10-year plan. We
will keep reminding them that for every $1 invested in medical
research, $2.17 is returned to the Australian economy in the form
of drug discoveries, better long-term health and, as a result, less
reliance on our overstretched healthcare system.
Warm regards,
Prof Geoffrey Donnan, AO
Director, the Florey Institute of Neuroscience & Mental Health
How’s your memory?
A new research project in Melbourne focuses on a subject that
is of concern to many of us – the worry that our memory seems
to be getting worse as we age.
While an increasing number of Australians are living with dementia,
most people who worry about their memory don’t actually have
the condition. A new study known as TREAD aims to detect people with very
early signs of problems with memory, but no significant disability.
The aim is to identify individuals who are suitable to participate
in clinical trials of promising therapies to prevent progression to
Alzheimer’s disease.
The study involves answering some questions from home, via the
internet, and then repeating this process on a monthly basis for a
few months or for the duration of the study. Each round of questions
should take about 15 minutes.
The study tests memory and thinking and uses games that don’t
require language skills. A person’s speed and accuracy is measured
every month for six months followed by every three months for up
to three years.
If you are aged 50 or over this project could an opportunity to
monitor cognitive changes in your memory and thinking. Anyone
who is detected to have significant memory decline problems will
be offered more detailed medical assessment in Melbourne or
advised how to access it if they wish.
Early detection and early treatment may one day prevent the
development of significant memory and thinking deterioration
and help reduce the burden of this terrible disease.
The study investigators are Associate Professors David Darby and
Amy Brodtmann of the Florey Institute of Neuroscience & Mental
Health and the University of Melbourne. Other collaborators
are Associate Professor Michael Woodward, director, Aged
and Residential Care Services, Austin Health, CogState Ltd and
Alzheimer’s Australia Vic.
If you or someone you know might be interested,
visit tread.florey.edu.au to find out more.
A winning combination
Florey neuroscientists are an enterprising
bunch, spurred-on by a stimulating work
environment and a desire to benefit
humanity. Their careers are punctuated
by moments of scientific discovery,
community engagement and the occasional
award for their commitment to brain
research. As you will read, the recognition
comes from around the world and helps
position the Florey as a major international
contributor to neuroscientific discovery.
Meet some members of our team who
have recently received awards for their
achievements.
The award crowned a number of
achievements in Ben’s career. Earlier in
2012, Ben was also awarded the Australian
Neuroscience Society’s AW Campbell
Award for early career excellence. The Florey
welcomed Ben back to Parkville following
an NHMRC CJ Martin fellowship where he
worked at Stanford University in the US.
Ben identified the myelin-gene regulatory
factor, which he has since shown is a master
regulator of myelination within the central
nervous system. This work was published
in Cell and has led to a single author review
in Science.
Emma Burrows
Each year,
the Victorian
Government
celebrates
excellence in science
and innovation by
awarding 12 Victoria
Fellowships to
early career researchers. The Florey’s own
Dr Emma Burrows, a talented postdoctoral
researcher specialising in models of brain
disease, is about to fly to Cambridge
University in England having won one of the
coveted awards.
Study missions offer the fellows the
opportunity to broaden their experience,
develop networks and better understand
how their work rates internationally. The
fellowship also provides an opportunity for
recipients to develop commercial ideas.
Emma hopes to bring home several new
ways to measure cognition after three
months abroad.
Emma studies brain disorders such as
dementia, schizophrenia, autism spectrum
disorders and drug addiction, each of which
can lead to major cognitive problems. Being
able to measure changes in cognition is vital
in the search for effective drug therapies.
Ben Emery
Multiple sclerosis
researcher, Dr Ben
Emery has a position
with the Florey
and the Centre
for Neuroscience
Research. He
has received
a prestigious Young Tall Poppy award,
recognising his significant results and
passion to engage with the community.
Shawna
Farquharson
Florey radiographer,
Shawna Farquharson
is a key talent at the
Florey’s Heidelberg
campus where
she produces and
analyses MRI scans
for patients who have a range of serious
neurological disorders including stroke
and epilepsy.
In an international first, Shawna has, for
the second time, won the President’s award
for producing the best scientific paper
offered to the Section Magnetic Resonance
Technologists. The International Society
for Magnetic Resonance in Medicine is
the leading international forum for education
and research in MRI for radiographers in
the world.
Importantly, this is the third time in the past
five years the Florey has won this award.
It recognises the high standard of imaging
and diagnosis offered to Australians involved
in neurological research at the Florey.
Jee Hyun Kim
Another talented
Florey scientist
is Dr Jee Hyun
Kim received two
awards in 2012.
The Australian
Psychological
Society Early Career Research Award
recognises excellence in scientific
achievement in psychology among
psychologists who are at early stages of their
research careers in Australia. This national
recognition was awarded to only two
Australians in 2012, and Dr Kim will be
presenting her body of work at APS conference
2013, her travel fully paid for by APS.
Jee also won the American D. G. Marquis
Behavioral Neuroscience Award for ‘best
paper published’ in the journal, Behavioral
Neuroscience. This international award is
sponsored by the American Psychological
Association. In the publication, Jee and her
colleagues showed that a different neural
circuitry underlies fear regulation early in
life, and that the lack of prefrontal cortical
involvement may reflect a less flexible
emotional regulation system in infant animals.
Jee holds an Australian Research Council
‘Discovery Early Career Research’
fellowship which is awarded to support
and advance promising early career
researchers and to enhance opportunities
for diverse career pathways. The award is
given to those working in high quality and
supportive environments.
Elizabeth
Manning
In 2012, the
University of
Melbourne’s
Graduate Student
Association awarded
the inaugural
Graduate Student
of the Year Award to PhD candidate Lizzie
Manning from the Florey. Lizzie researches
the highly addictive drug known as ‘ice’ and
its links to schizophrenia and psychosis.
Lizzie is a founding member of the
Students of Brain Research group which
encourages collaborative links across
scientific institutions, and in 2011 she was
a student representative of the University
of Melbourne Neuroscience Learning and
Training Committee. She often volunteers
her time to the community by presenting
research in mental health disorders and the
brain to VCE psychology students through
the Florey’s Mindfields program. As well,
in late 2012, Elizabeth was selected as a
member of the Australian Academy of
Science Early-Mid Career Researcher Forum
where she discussed policy to encourage
and develop scientific careers.
To support one of these talented researchers,
please call Ross Johnstone on 03 8344 1822.
Autumn 2013
Brain Matters3
Keeping watch
over Parkinson’s
research
There is currently no cure for Parkinson’s
disease but Florey scientists are tackling
it from several angles. This awful disease
affects one in every 350 Australians.
Parkinson’s disease is a progressive and
degenerative condition that impairs
movement and thinking. It is Australia’s
second most common neurological disease
and has grown by 17 per cent over the last
six years. Its prevalence will increase as the
population ages.
Research is vital as the disease is more
common than prostate, bowel and many
other cancers. According to Parkinson’s
Australia, the estimated burden of the
disease for last financial year was $7.6 billion
with 20 per cent of Parkinson’s sufferers of
working age.
The Florey’s research takes a wide-ranging
approach. We are trying to find the causes
of Parkinson’s and different ways to identify
it before symptoms appear. Researchers are
at the cutting edge – looking at the birth and
development of a neuron through to stem
cell investigations, new drug therapies and
a novel wristwatch device to help better
manage a patient’s medication regime.
We also run the Australian Parkinson’s
Disease Registry.
Keeping watch…
Senior researcher and neurologist, Professor
Malcolm Horne, is the brains behind an
Australian-first invention, a wristwatch-like
device called the Kinetigraph system. It is now
on the international market and is significantly
improving the treatment of people with
Parkinson’s disease. The watch and computer
software allow patients and neurologists to
accurately measure how the disease affects
movements. The device is worn on the wrist
and records data for a few weeks prior to
a visit to the neurologist. A sensor records
data about symptoms and a computer unit
receives the data and analyses it.
4
Autumn 2013
Prof Home says the system is the first in the
world to successfully provide Parkinson’s
specialists with accurate information about
the symptoms experienced by their patients.
The device is particularly useful for patients
at the intermediate stage of the disease,
when the effectiveness of drugs that control
the symptoms are beginning to wane.
“There are about three stages in Parkinson’s,”
he says. “The first major problems are to
do with slower, restricted movements, and
medication works well for about three and
five years. At first it’s just three tablets a day,
Stem cells are responsible for repair and
regeneration of damaged and ageing tissues.
Our scientists are very interested in whether
they can harness the regenerative potential
of stem cells to be able to grown new
cells for treatments to replace diseased or
damaged tissue in the body.
Dr Clare Parish and Dr Lachlan Thompson
are aiming to eventually implant embryonic
stem cells into the brains of people with
Parkinson’s disease, perhaps one day
replacing medication as the best way to
alleviate symptoms.
The Florey’s research takes a wide-ranging
approach. We are trying to find the causes
of Parkinson’s and different ways to identify
it before symptoms appear.
but then the problem in the middle stage is
that the dose of the medication doesn’t last
as long any more – it wears off more quickly
and becomes unreliable.”
Until now, neurologists have relied on the
patient to explain their symptoms and the
neurologist has had to work out how to treat
them, but the Kinetigraph system gives them
a much clearer view, allowing medication
use to be adjusted, based on more accurate
information. The high-tech measuring device
will also allow specialists to use major
interventions like surgery in a more sensible
and cost- effective way.
Stem cell hopes
Stem cell science is an extremely fast moving
field of research with new breakthroughs
being reported almost daily. This swiftly
changing landscape has seen many different
stem cell types and technologies capture the
public’s imagination including embryonic
stem cells, tissue stem cells, umbilical cord
blood stem cells, and more recently, induced
pluripotent stem cells.
People with Parkinson’s gradually lose
dopamine-producing neurons, affecting their
motor skills and causing their limbs to shake.
The team is working to reprogram
embryonic stem cells so they can act as the
dopamine neurons would normally. While
the technique needs to be refined before
clinical trials start, Dr Thompson hopes one
day transplanted cells will help Parkinson’s
patients.
“There is still a lot of basic research to do
to develop this technology to a point where
it would be safe to proceed with trials in
patients, however, there’s no reason to think
that it couldn’t happen within the next five
to 10 years with the proper funding,”
Dr Thompson says.
For enquiries about the Kinetigraph system,
please contact: Andrew Maxwell
at Global
Kinetics
03 9605 0034 .
Would you like to help fund the Florey’s
Parkinson’s researchers? Please call Ross
Johnstone to discuss how you might be able
to contribute: 03 8344 1822.
The Michael J. Fox Foundation
The American actor, Michael J. Fox,
52, was diagnosed with young-onset
Parkinson’s disease in 1991. After going
public in 1998, he committed himself to
a campaign for increased Parkinson’s
research. He set-up the Michael J. Fox
Foundation and to date, it has provided
$US313 million to medical research.
Three Florey scientists are recent
recipients of a $125,000 grant. Dr Scott
Ayton, Assoc Prof David Finkelstein
and Professor Ashley Bush will study
alpha-synuclein, a key protein involved
in Parkinson’s disease.
Attempts have been made with drugs
to lower the amount of this protein in
the brain as a potential treatment for
Parkinson’s disease. However, neither
the normal function of this protein nor
the consequences of its reduction,
by using drugs for example, are well
understood. The Florey researchers aim
to investigate pre-clinical models with
no alpha-synuclein and models with
half the amount of alpha synuclein
to determine if they develop adverse
symptoms. While many potential
therapeutic strategies have been devised
to lower the amount of alpha-synuclein
in the body of patients with Parkinson’s
disease, this project will investigate
whether lowering alpha-synuclein is a
safe approach as a therapeutic strategy
for Parkinson’s disease.
Parkinson’s lecture with
Professor Mal Horne
Topic: Cognitive and psychological
issues in Parkinson’s
Where: Auditorium, Melbourne Brain
Centre, 30 Royal Parade, Parkville.
When: April 11 at 6.30pm for one hour.
Please note: for those unable to attend,
we will put a video of the session on our
website in the days following.
Enquiries: Anna on 03 9035 7006.
There is plenty of disabled parking
under the building.
Proudly supported by Parkinson’s Victoria.
Professor Malcolm Horne wearing the Kinetigraph
– a device he has been working on for 23 years.
Autumn 2013
Brain Matters5
Do illicit
drugs cause
psychosis?
A/Prof Maarten van den Buuse is studying the link between drug abuse and psychosis
Associate Professor Maarten van den Buuse has been studying
the link between drug abuse and psychosis for a long time.
Recently, members of his team published a well-received review
of the available research findings on the link between drug abuse
(particularly cannabis and methamphetamine) and psychosis
development. Their review is certainly timely given current drug
policy debates.
This brief summary, of course, oversimplifies the issue, and the
review also highlights the complex and often conflicting nature of
the evidence. For instance, the incidence or prevalence of psychosis
has remained stable over the last two decades, despite significant
increases in use of cannabis and stimulants. Nevertheless, multiple
large-cohort studies have found that drug use remains a risk factor
for psychosis, supporting a link between drugs and psychosis which
may involve both direct causative effects and shared vulnerabilities.
“Our overview showed increasing evidence that illicit drugs play
a causal role in at least some individuals with psychosis and/or
schizophrenia,” Maarten said. “Firstly, animal studies demonstrating
the effects of cannabis or stimulant administration show that these
effects are greatest when exposure to drugs occurs during critical
developmental stages. There is also a “dose effect”, where a greater
quantity of drug use is associated with more psychotic symptoms
in experimental and clinical studies with recreational drug users.
Among other findings, research also demonstrates that cannabis
use may double the risk of schizophrenia development in vulnerable
individuals – in fact, it has been estimated that from 7% to 25% of
incident cases of schizophrenia may be attributable to cannabis.”
The relationship between stimulants and psychosis is probably at
least as strong as that for cannabis. Amphetamines effects are linked
to dopamine in the brain, and unlike many other drugs, these effects
sensitise rather than habituate with repeated use. However, because
of their less frequent use and almost universal overlap with cannabis
and other substances, they have been less systematically studied,
underlining the particular need for further research on stimulants.
In short, cannabis and stimulants do appear to play a causal role in
psychosis. Evidence about the impact of drug use on psychosis is
relevant to current debates on drug policy, and this review may help
to inform some of the difficult trade-offs inherent in any position on
this complex problem.
Postcard from Gippsland
Donor and Alumni Relations officer Hazel Westbury enjoyed a visit
to several Gippsland-based friends of the Florey recently. Each had
their own story to tell about how they came to be engaged with
the Florey, but all agreed that the connection adds meaning and
relevance to their lives.
Gwen Webb OAM of Sale was the founding director of Sale Regional
Art Gallery and is a true regional pioneer. She was inspired by
Professor Fred Mendelsohn’s visit to the region several years ago, and
was delighted that the Florey had sent a staff member all the way
to see her. Jean Mathews, also from Sale, recently lost her husband
Tom who suffered Parkinson’s for the last four years of his life. Evelyn
Fawcett of Leongatha also remembers Prof Mendelsohn’s moving talk
to the local Probus Club several years ago, and is further inspired to
support the Florey because her grandson suffers from epilepsy.
6
Autumn 2013
Trafalgar-based Enid Telford’s late husband Kel died several years ago
after a long decline into Alzheimer’s. To keep alive the memory of
Kel’s love of photography, verse and their combined creative talents,
Enid and her daughter Sue decided to make and sell cards to raise
funds for research
into Alzheimer’s.
Enid’s home is now
a cottage business
where cards are
conceived and
assembled, ready
for sale at local
markets and fairs.
This remarkable pair
has raised more than
$10,000 so far!
Vitamin D’s role
in multiple sclerosis
Please turn my support
into hope for Alzheimer’s
disease, stroke, Parkinson’s
disease, depression and
other mental illnesses.
A world first clinical trial in Australia and New Zealand will test
the role of Vitamin D in those at risk of developing multiple
sclerosis (MS). Tasmania, with the highest incidence of MS in
Australia, is playing a key role in the trial, with Florey researchers
in Melbourne also involved.
First name:
Three out of four MS sufferers are women who are usually
diagnosed in their 20s and 30s. Though the causes of MS are
unknown, a deficiency of Vitamin D (which is primarily synthesized
in the skin by exposure to UV light) is now thought to play a major
role in some patients.
Surname:
Address:
This trial will test whether using vitamin D supplements can prevent
a diagnosis of MS following a person’s presentation with the first
symptoms. It will also test appropriate dosage levels and safety,
information that may in time lead to an effective prevention strategy
for MS.
Known as PrevANZ, the trial is being funded by MS Research
Australia through the support of state-based MS societies, especially
from Western Australia, Queensland and Tasmania. Trial subjects will
be recruited solely through neurologists. People already diagnosed
with MS who are concerned about their vitamin D status should
discuss this with their GP or neurologist.
Helping our research
to flourish
State:
Postcode:
Email:
I would like more information about remembering the
Florey Institute of Neuroscience & Mental Health in my will.
I would like more information about making automatic
reguar donations.
Enclosed is my
cheque
money order.
or debit my
Mastercard
Many of you will know
about the organisation
One in Five; they
have been a great
supporter of mental
health research over
many years, running a
range of events to raise
money. Since 2004
they have raised over
$1.6 million.
One in five Australians suffers from mental illness. On top of the
misery it creates for sufferers and their families, mental illness comes
at an enormous cost to the Australian economy: six million working
days are lost and 30 million working days are affected by reduced
productivity due to depression.
One in Five is supporting research led by the Florey’s Associate
Professor Suresh Sundram: “This last year has been replete with
intriguing and complex findings that are both unexpected and
somewhat serendipitous,” says Suresh. “We have proposed that
a particular signalling system in the brain… may be disrupted in
psychotic disorders like schizophrenia and bipolar disorder. An
unusually effective (but toxic) medication, clozapine, may exert
some of its beneficial effects through this system.”
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Thank you for your valuable support. All donations are
tax deductable.
I would like to donate $
Call our freecall credit card donation line
on 1800 063 693
Or fax your donation to us on (03) 9035 3107
Or send your donation to the Florey Institute of Neuroscience
& Mental Health, 30 Royal Parade, Parkville, VIC 3052
You can also donate online at www.florey.edu.au
The Florey Institute of Neuroscience & Mental Health records information about
its supporters that includes address and donation details. This information is used
solely by the Institute and is not sold, traded or passed on to any third parties. If
you no longer wish to receive further information, please tick this box and return
this coupon by mail.
One in Five’s support and the many individuals who fundraise
through team and individual events help to ensure Suresh’s research
can continue. Many thanks from all at the Florey. If you would like
to become involved, please visit: www.oneinfive.com.au
Autumn 2013
Brain Matters7
News & events
Funny neuroscience?
The Florey is holding an event as part of the
Melbourne International Comedy Festival.
Several of our researchers have volunteered
to deliver a stand-up routine when they will
draw on their scientific careers to talk on the
topic of “my first time”. Guest comedians
Catherine Deveny and Ben McKenzie will
support the motley crew.
To book: comedyfestival.com.au/2013/season/shows/brains-collide-thinky-stuff
The event will take place at 6pm on April 2 at the Melbourne Brain Centre, 30 Royal Parade, Parkville.
Ketocooking – new cook book for sale
Child neurologist, Professor Ingrid Scheffer has helped write a
cookbook for children who are unable to tolerate conventional
anti-epileptic drugs. A ketogenic diet is a medically managed,
metabolic diet with proven benefits – some 50 per cent of
children will experience some remission of their symptoms
and 10 per cent will become seizure-free. The book explains
the diet and offers simple and tasty recipes to help parents.
All profits will go to the Florey.
Order on-line at www.florey.edu.au , order by phone through
(03) 9035 7012, or purchase your copy from the Florey’s Austin
campus at 245 Burgundy Street, Heidelberg, Victoria.
English Channel Crossing
for Mental Health
Parkinson’s warriors
on the move
Mental health research supporter Matt Harry
is preparing for his charity swim across the
English Channel in August! You can help
Matt to reach his goal and through his blog
you can experience his “mind marathon”
and raise vital funds for the Florey. Go Matt!
Rob Sadler was diagnosed with Parkinson’s
in 2004 and has been trialling the Florey’s
Kinetigraph system (see page 4-5) with
his neurologist Dr Kate Kotschek. Rob
is planning to drive up the east coast of
Australia with his teenage son, Linden,
from September to November 2013. He is
arranging events and speaking engagements
along the way to raise funds for Parkinson’s
research at the Florey.
Read Matt’s blog here marathonforthemind.
wordpress.com
To support Matt visit everydayhero.com.au/
matt_harry
For more information contact the Editor,
Amanda Place: amanda.place@florey.edu.au
or +61 411 204 526
Visited the Florey website lately?
Go to florey.edu.au
Find us on Facebook and Twitter
at our website: florey.edu.au
The Florey Institute of Neuroscience & Mental
Health is the amalgamation of the Howard Florey
Institute, the Brain Research Institute, The Mental
Health Research Institute and the National Stroke
Research Institute.
Articles and photographs that appear in this
publication remain the property of the Florey
Institute of Neuroscience & Mental Health and
may not be reproduced without permission.
Copyright © 2013.
Another person heading for the road again
(but in a different vehicle this time) is our
Parkinson’s pedaller Kieran Donlon who has
sold the family home and will soon take to
the road with wife Julie to explore Australia.
We hope Kieran, Julie and Rob meet-up
along the way. Getting these solid gold
Aussies together to talk about Parkinson’s
from the perspectives of patient and carer
would be an amazing experience!
The Florey thanks our
recent major donors:
The William Angliss (Vic) Charitable Fund
Australian Communities Foundation
David Barkley
Terence Bates
Walter Beale
Besen Family Foundation
Jean Bowles
Georgia Burns
C M Carrigan
Estate of the late Anne D Carroll
Ce Soir Lingerie
Christian College Highton
John Collingwood
Cotton On Foundation Pty Ltd
Ernest F Dawes OBE FTS
Disha
David & Karen Dowdle
Craig Drummond
Andrew Erikson
Equity Trustees Limited
Fairlane Images
The Marian & E H Flack Trust
Foresters Friendly Society
A K Fryday
The Greatorex Foundation Pty Ltd
The Grocer
Joy Guerin
Ronda Hall
Professor Phillip Hamilton
Geoff & Helen Handbury Foundation
George R & J M James
H & K Johnston Family Foundation
J F Kearney
A P Kelly
Margaret Livermore
Lord Mayor’s Charitable Foundation
The Eirene Lucas Foundation
Margarete Pty Ltd
Joel Marsden
Mrs Judith Moore
S Baillieu Myer AC
The Myer Foundation
Dennis & Fairlie Nassau
Mark & Louise Nelson
One in five Association Inc
Sue O’Neill & Enid Telford
Judith Overbeek
Parkinson’s Victoria Inc
Perfect Events
Reece Australia Ltd
Ralph & Ruth Renard
Joan Russell
Scope
Mark Simcocks
P Smart
Russell Stewart
R E Swanson
Dr Christine Sweeney
Gregory & Wendy Taggart
Robert C Thrower
Trust Company Ltd
UK Fund for Charities
The Urquhart Charitable Fund
David Vernon
Wendy Wagstaff
Mr Harrison Young
Donations in memory of:
Murray Black
Sigrid Halasz
Joan Margaret James
Christopher Barr Mallen
Thomas Hugh Matthews
Brent Proctor
Elizabeth Anne Smyth
Michael (Mick) Wardlaw
Gifts in celebration of:
50th wedding anniversary of Diana & Ed Cherry
florey.edu.au