Principles of Medical Physiology
Course Syllabus
Course Number:
GMS 6400c
Credit Hours:
6 credit hours
Course Format:
This online course is tailored for asynchronous distance learners.
COURSE DESCRIPTION
Principles of Medical Physiology (GMS6400c) teaches the functions of the human body at a level required for
clinical medicine. The course covers normal physiology, as well as selected diseases. Concepts are organized by
systems: Endocrine, Cardiovascular, Respiratory, Renal and Gastrointestinal. Additional content includes an
introductory section on the cell and autonomic nervous system and a final integration across the organ systems.
The ultimate goal is for students to develop an understanding of the integrated functions of the normal body and
“problem solving” and “critical thinking” skills in evaluating clinical situations.
TARGET AUDIENCE
This course is designed to meet the needs of individuals wanting to pursue a career in medicine or medical
research. This course will provide a foundation for students who have not met the entry requirements for
medical school and for those wishing to enhance their applications into Masters and PhD programs in the
medical sciences.
PREREQUISITES
This course requires a BA or BS and a strong science foundation with at least 5 full semester courses related to
Biology, chemistry and/or physics. A minimum undergraduate GPA = 2.0 is required for admission.
CONTACTS
Bruce R. Stevens PhD. Professor of Physiology and Functional Genomics, stevensb@ufl.edu; Tel: 352-3924480.
SCHEDULE
This is a 15 week course that is offered in the spring, fall and summer
COURSE GOALS
Physiology is the science of how the body functions, and is the basis for understanding modern clinical
medicine and the biomedical sciences. This course will 1): Provide a foundation understanding of the basic
functions of the human body. 2): Knowledge of the physiology of the major systems: endocrine,
gastrointestinal, cardiovascular and muscle, respiratory and renal physiology as well, as well as selected
diseases that affect these systems. 3): Integration of these individual facts in order to understand how organ
systems work independently and interdependently in the body. One example of this integration is in the control
of acid base balance. Other examples covered in this course are in the integrated responses to pregnancy and
exercise as well as patho-physiologic responses to aging.
LEARNING OUTCOMES
Upon completion of this course, students will be able to:
1. Understand the normal functions of the individual body systems at a level required for an
understanding of clinical medicine.
2. Understand how these systems act in an integrated manner to regulate overall body functions.
3. Understand how failure of these normal physiologic functions and integrations are associated with
some diseases.
4. Demonstrate the ability to apply physiological principles of clinical relevancy by multiple choice
examinations and Quiz exercises.
LEARNING RESOURCES
1. Recorded lectures with PowerPoint presentations, workshops and virtual laboratory exercises will be
provided on the course website.
2. Recorded clinical correlation(s) and/or case studies relating to the basic science material.
3. Online Q/A bulletin board and discussion website where students can post questions, which faculty will
answer within the bulletin board.
4. Practice on-line quizzes to advance the understanding of the material provided in lectures.
5. Example exam questions to test knowledge and prepare for the 5 examinations.
6. Recorded Pre-Exam Review Sessions for each of the five sections, for the class to review material
covered on each exam.
7. Text: The course textbook is “Berne & Levy Physiology, 6th Edition, Updated”, 2010. Author: Bruce
M. Koeppen & Bruce A. Stanton. ISBN: 9780323073622. In addition, the lecture notes are available as
PDF downloads enabled for direct notetaking.
EXAMINATIONS AND GRADING
There will be 5 multiple choice examinations, which will cover the contents of each module (Introduction +
endocrine, cardiovascular and muscle, respiratory, renal and gastrointestinal + Integrated physiology). All
exams will be monitored by ProctorU, a UF chosen service that allows the students to complete their exams
while still ensuring academic integrity. Students will take all examinations at a computer that meets the
technical requirements of ProctorU including a web cam and microphone. Students will make the arrangements
for exam proctoring. We recommend you make an appointment at least two weeks in advance to the exam date.
The points used to compute final grades will be determined after all exams have been completed, with 20% of
the grade from each of the 5 modular examinations.
In order to be awarded the certificate, students must maintain an average GPA of 3.0 or better.
Grading scale:
A numerical grade will be given at the end of the course and will be scored as follows:
93-100% = A
90-92%= A87-89% = B+
83-86% = B
80-82% = B77-79% = C+
73-76% = C
70-72% = C67-69% = D+
63-66% = D
<63% =E
GRADING POLICY
There are no make-up exams unless otherwise granted by the course coordinator prior to an examination date.
Failure to take an exam without prior permission from the course coordinator will be recorded as 0.
ACADEMIC HONESTY
Please review the complete policy of the University of Florida regarding academic dishonesty, found in the
online student handbook at: http://www.dso.ufl.edu/judicial/pdffiles/handbook 2003.pdf
Students are expected to abide by the University of Florida Academic Honesty Guidelines and to adhere to
the following pledge:
“We, the members of the University of Florida community, pledge to hold ourselves and our peers to the
highest standards of honesty and integrity.
On all work submitted for credit by students at the University of Florida, the following pledge is either required
or implied:
"On my honor, I have neither given nor received unauthorized aid in doing this assignment."
Copyright © 2013 Department of Physiology and Functional Genomics, University of Florida
All course content including faculty lectures are copyrighted, including handouts and spoken audiovisual
representations.
PHYSIOLOGY FOUNDATIONAL BASICS
Section Coordinator Bruce Stevens, Ph.D. (stevensb@ufl.edu)
Introduction to Medical Physiology
Transporters, Pumps, and Channels – Part I
Transporters, Pumps, and Channels – Part II
Physiology of Voltage & Concentration Gradients – Part I
Physiology of Voltage & Concentration Gradients – Part II
Body Fluids I
Body Fluids II
Receptors and Signaling – Part I
Receptors and Signaling – Part II
Autonomic Nervous System – Part I
Autonomic Nervous System – Part II
Autonomic Nervous System – Part III
Quiz
Stevens
Stevens
Stevens
Stevens
Stevens
Baylis
Baylis
Sumners
Sumners
Scheuer
Scheuer
Scheuer
Faculty
ENDOCRINE PHYSIOLOGY
Section Coordinator Kirk Conrad M.D. (kpconrad@ufl.edu )
Introduction to Endocrinology
Hypothalamus and Pituitary – Part I
Hypothalamus and Pituitary – Part II
Adrenal Medulla – Part I
Adrenal Medulla – Part II
Adrenal Cortex – Part I
Adrenal Cortex – Part II
Thyroid Hormones – Part I
Thyroid Hormones – Part II
Clinical Correlation: Thyroid – Part I
Clinical Correlation: Thyroid – Part II
Calcium/Phosphate Regulation - Part I
Calcium/Phosphate Regulation – Part II
Calcium/Phosphate Regulation – Part III
Calcium Phosphate Regulation – Par IV
Fluid Balance & Cardiovascular Control
Quiz 1
Growth Hormone -Part I
Growth Hormone – Part II
Blood Glucose Regulation – Part I
Blood Glucose Regulation – Part II
Reproduction (Sexual Differentiation – Part I)
Reproduction (Sexual Differentiation - Part II)
Reproduction Male – Part I
Reproduction Male – Part II
Reproduction Female – Part I
Reproduction Female – Part II
Reproduction Female – Part III
Reproduction Female – Part IV
Reproduction Pregnancy – Part I
Reproduction Pregnancy – Part II
Reproduction Pregnancy – Part III
Reproduction Pregnancy – Part IV
Clinical Correlation : Assisted Reproductive Technologies – Part I
Clinical Correlation: Assisted Reproductive Technologies – Part II
Quiz II
Review
Multiple Choice Exam on Foundational Basics and Endocrine
Sumners
Sumners
Sumners
Sumners
Sumners
Wood
Wood
Sumners
Sumners
Winter
Winter
Sumners
Sumners
Sumners
Sumners
Sumners
Faculty
Raizada
Raizada
Raizada
Raizada
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Conrad
Rhoton
Rhoton
Faculty
Faculty
MUSCLE AND CARDIOVASCULAR
Section Coordinator Judy Delp Ph.D., (jdelp@ufl.edu)
The Structure of Muscle-Skeletal, Cardiac, Smooth – Part I
The Structure of Muscle-Skeletal, Cardiac, Smooth – Part II
Muscle Function and Regulation – Part I
Muscle Function and Regulation – Part II
Muscle Dysfunction and Disease – Part I
Muscle Dysfunction and Disease – Part II
Clinical Correlation-Muscular Dystrophy – Part I
Clinical Correlation-Muscular Dystrophy – Part II
Walter
Walter
Walter
Walter
Walter
Walter
Walter
Walter
Overview of cardiovascular Physiology
Cardiac Cycle – Part I
Cardiac Cycle – Part II
Electrocardiogram – Part I
Electrocardiogram – Part II
Cardiac Ion Channels – Part I
Cardiac Ion Channels – Part II
Heart Sounds 1
Heart Sounds 2
Quiz 1
Pulmonary Circulation- Part I
Pulmonary Circulation- Part II
Fetal Circulation
Hemodynamics, Arteries – Part I
Hemodynamics, Arteries – Part II
Venous Return – Part I
Venous Return – Part II
Neural Control – Part I
Neural Control – Part II
Neural Control – Part III
Local/humoral control of flow
Modulators of blood flow
Microcirculation – Part I
Microcirculation – Part II
Heart Failure-Clinical correlation – Part I
Heart Failure-Clinical correlation – Part II
Quiz 2
Review
Multiple Choice Exam on Muscle and Cardiovascular
Delp
Delp
Delp
Delp
Delp
Delp
Delp
Gessner
Gessner
Faculty
Scheuer
Scheuer
Wood
Wood
Wood
Wood
Wood
Scheuer
Scheuer
Scheuer
Delp
Delp
Delp
Delp
Delp
Delp
Faculty
Faculty
RESPIRATORY PHYSIOLOGY
Section Coordinator: Peter P. Sayeski, Ph.D. (psayeski@ufl.edu )
Introduction to Respiratory Physiology
Lecture: Functional Anatomy
Lecture: The Respiratory Pump and Lung Volumes
Lecture: Lung Compliance Part I
Lecture: Lung Compliance Part II
Lecture: Airway Resistance Part I
Lecture: Airway Resistance Part II
Lecture: The Work of Breathing Part I
Lecture: The Work of Breathing Part II
Lecture: Alveolar Ventilation and Gas Composition Part I
Lecture: Alveolar Ventilation and Gas Composition Part II
Lecture: Gas Diffusion Part I
Lecture: Gas Diffusion Part II
Lecture: Oxygen Transport Part I
Lecture: Oxygen Transport Part II
Quiz
Lecture: Oxygen Content Part I
Lecture: Oxygen Content Part II
Lecture: CO2 Transport and Content
Clinical Correlation: O2 Assessment
Clinical Correlation: CO2 Assessment
Lecture: Pulmonary Circulation Part I
Lecture: Pulmonary Circulation Part II
Clinical Correlation: Pulmonary Edema Part I
Clinical Correlation: Pulmonary Edema Part II
Lecture: Acid-Base Part I
Lecture: Acid-Base Part II
Lecture: Respiratory Control Part I
Lecture: Respiratory Control Part II
Lecture: High Altitude Respiration
Quiz
Clinical Correlation: Case Studies Part I
Clinical Correlation: Case Studies Part II
Review
Multiple choice Exam on Respiratory Physiology
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
Sayeski
RENAL
Section Coordinator Chris Baylis Ph.D. (baylisc@ufl.edu )
Introduction to Renal Physiology
General Functions of the Kidney. Renal Anatomy
Cl Clearance- Part I
Clearance Part II
Renal Hemodynamics – Part I
Renal Hemodynamics – Part II
Renal Hemodynamics – Part III
Renal Hemodynamics – Part IV
Control of sodium balance – Part I
Control of sodium balance – Part II
Control of sodium balance – Part III
Control of sodium balance – Part IV
Renal epithelial sodium transport – Part I
Renal epithelial sodium transport – Part II
Quiz 1
Renal handling of Calcium and Phosphate- Part I
Renal handling of Calcium and Phosphate- Part I
Renal handling of Potassium - Part I
Renal handling of Potassium - Part II
Concentration and Dilution – Part I
Concentration and Dilution – Part II
Concentration and Dilution – Part III
Concentration and Dilution – Part IV
Clinical Cases Set1: Volume crises – Part I
Clinical Cases Set 1: Volume crises – Part II
Acid/Base Balance – Part I
Acid/Base Balance – Part II
Acid/Base Balance – Part III
Acid/Base Balance – Part IV
Clinical Cases Set 2: Acid Base – Part I
Clinical Cases Set 2: Acid/Base – Part II
Clinical Cases Set 3, Kidney Disease – Part I
Clinical Cases Set 3, Kidney Disease – Part I
Quiz 2
Review
Multiple choice exam on Renal Physiology
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Baylis
Weiner
Weiner
Baylis
Weiner
Weiner
Weiner
Weiner
Baylis
Baylis
Baylis
Baylis
Segal
Segal
Weiner
Weiner
Weiner
Weiner
Weiner
Weiner
Tantravahi
Tantravahi
Baylis
Weiner, Baylis
GASTROINTESTINAL
Section coordinator Bruce Stevens Ph.D. (stevensb@ufl.edu )
Introduction to Gastrointestinal Physiology
GI Enteric Nervous System and Motility -- Part I
GI Enteric Nervous System and Motility -- Part II
GI Enteric Nervous System and Motility -- Part III
GI Enteric Nervous System and Motility – Part IV
Salivary Glands & Exocrine Pancreas – Part I
Salivary Glands & Exocrine Pancreas – Part II
Stomach and Gastric Acid Control – Part I
Stomach and Gastric Acid Control – Part II
Zollinger-Ellison Syndrome of Acid Hypersecretion
Carbohydrate & Protein Digestion/Absorption – Part I
Carbohydrate & Protein Digestion/Absorption – Part II
Gastrointestinal Microbiota
Liver & Gallbladder – Part I
Liver & Gallbladder – Part II
Lipid Digestion; Enterocyte Metabolism & Absorption – Part I
Lipid Digestion; Enterocyte Metabolism & Absorption – Part II
Intestinal Water and Electrolytes Absorption/Secretion – Part I
Intestinal Water and Electrolytes Absorption/Secretion – Part II
Quiz
Review
(Note: GI exam will be included later with Integrated Physiology exam)
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
McGuigan
Stevens
Stevens
Mai
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
Stevens
INTEGRATED PHYSIOLOGY
Section Coordinator Chris Baylis Ph.D. (baylisc@ufl.edu )
Pregnancy Physiology: Maternal – Part I
Baylis
Pregnancy Physiology: Maternal – Part II
Baylis
Pregnancy Physiology: Fetal – Part I
Wood
Pregnancy Physiology: Fetal – Part II
Wood
Aging Physiology: Kidney
Baylis
Aging Physiology: Cardiovascular
Delp
Exercise Physiology and Muscle – Part I
Walter
Exercise Physiology and Muscle – Part II
Walter
Exercise Physiology and Cardiovascular – Part I
Delp
Exercise Physiology and Cardiovascular – Part II
Delp
Exercise Physiology and Lungs
Sayeski
Quiz
Faculty
Review
Faculty
Multiple choice exam on Gastrointestinal and Integrated Physiology