EUROPE UK USA ACROS ORGANICS Geel West Zone 2 Janssen Pharmaceuticalaan 3a 2440 Geel Belgium FISHER SCIENTIFIC UK LTD Bishop Meadow Road Loughborough Leicestershire LE11 5RG United Kingdom ACROS ORGANICS 500 The American Road Morris Plains, NJ 07950 The United States of America Tel +32 (0)14 57 52 11 Fax +32 (0)14 59 34 34 Tel (01509) 231 166 Fax (01509) 231 893 info@acros.com http://www.acros.com info@fisher.co.uk http://www.fisher.co.uk/acros For all your fine and custom chemistry needs, please contact Acros Organics: Tel +1 973 753 1940 Fax +1 973 644 9369 http://www.fishersci.com For all your fine and custom chemistry needs, please contact: Tel (01509) 555 806 Fax (01509) 555 015 chemicals@fisher.co.uk Welcome! Think Acros Organics, think Chemistry… Customized. EXAMPLE TECHNOLOGY CAPABILITIES: i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i Acetylation Acylation Alcoholysis Alkoxylation Alkylation Amidation Amination Aromatic iodination (and deiodination) Aromatic hydroxymethylation Asymmetric synthesis Bromination Carbomethylation Carboxylation Chiral synthesis Chlorination Chlorosulfonation Condensation Cyanation Cyclization Dealkylation Decarboxylation Dehalogenation Dehydrogenation Diazotisation Diels alder reaction Epoxidation Esterification Friedel crafts reactions Grignard reactions Halide exchange i i i i i i i i i i i i i i i i i i i i i i i i i i i i i Halogenation Hoffman reaction Hydroformylation Hyrogenation Hydroxylation Isomerisation Mannich reaction Metathesis Methylation Nitration Nitrosation Organometallic reactions Oxidation Peptide synthesis Phosphination Phosphorylation Quaternization Reduction Reactions with enzymes Reaction with liquid ammonia Resolution of racemates Sandmeyer reaction Saponification Schmidt reaction Sulphonation Thioester formation Tosylation Tranesterification Transfer phase reactions Leverage our vast knowledge and experience in organic chemistry to meet your challenges. At Acros Organics, we offer contract research, process development and manufacturing services from initial route selection and optimization, to process scale up and the production of novel molecules in commercial quantities. Exclusive custom synthesis and contract manufacture are undertaken for clients in complete confidentiality within Acros Organics’ own kilolab, pilot scale and multi-purpose production facilities located in the UK, Belgium and the USA. Products can be supplied in milligram to ton quantities and can be manufactured to ISO 9001:2000 and cGMP quality standards. Where appropriate, production can also be managed through technical transfer to specialist third party manufacturers. Specialist expertise in heterocyclic and nucleic acid chemistries is also available through the Acros Organics affiliate organizations, Maybridge and Pierce Nucleic Acid Technologies. PROCESS DEVELOPMENT AND SCALE UP Not only does our Process R&D Department has access to over 120,000 proprietary synthetic chemistry processes developed within Acros Organics and Fisher Scientific, but it continually develops diverse and complex chemistries to meet the unique requirements of our customers globally. Process research and scale up resources include development laboratories, cGMP and ISO:9000:2000 compliant kilolabs containing over 20 fume hoods with equipment up to 50 liters, and pilot scale facilities. Senior development chemists oversee these custom projects and communicate directly with customers providing progress and project reports. Expert teams of dedicated analytical chemists support both process development and manufacturing activities, ensuring quality at every step of the process. See the table opposite for a partial listing of our technology capabilities. CUSTOM SYNTHESIS AND CONTRACT MANUFACTURE Acros Organics Fine and Custom Chemistry business specializes in the exclusive manufacture of chemicals for which either the entity or specification is not commercially available. Our vast process knowledge and experience of manufacturing thousands of different chemicals makes us ideally qualified to develop specialty products for customers. Our team of organic chemists, chemical engineers and project managers keenly understands the customized service necessary to produce novel compounds. Our extensive facilities enable us to provide a fast, accurate turnaround of full scale specialist chemicals to the most exacting requirements either as a single synthesis or as contract manufacture on an ongoing basis. Our operations can handle most requirements. Laboratory, pilot scale and multi-purpose production facilities contain glass, glass-lined and stainless steel vessels with capacities up to 5,000 liters allowing production of quantities from milligrams to tons and to ISO9000:2000 and cGMP quality standards as required. Think Acros Organics, think chemistry…customized. Custom Synthesis and Contract Manufacture ACROS FINE AND CUSTOM CHEMISTRY