CRS Chapter Report Hawaii 2013 – Canada Chapter
Chapter Name: Canadian Chapter of the Controlled Release Society (CC-CRS)
Date Established: 2009
Board of Directors (list names and positions):
President: Michael R. Doschak
University of Alberta
Faculty of Pharmacy & Pharmaceutical Sciences
Edmonton, Alberta, Canada
E-mail: mdoschak@ualberta.ca
Vice President: Laurent Lecanu
McGill University, Department of Medicine
The Research Institute of the McGill University Health Centre
Royal Victoria Hospital
Montreal, Quebec, Canada
E-mail: Laurent.lecanu@mcgill.ca
Secretary: Todd Hoare
McMaster University
Department of Chemical Engineering
Hamilton, Ontario, Canada
E-mail: hoaretr@mcmaster.ca
Treasurer: Larry Unsworth
University of Alberta
Department of Chemical and Materials Engineering
National Institute for Nanotechnology (NRC-NINT)
Edmonton, Alberta, Canada
E-mail: larry.unsworth@ualberta.ca
Past President: Jake Barralet
Professor
McGill University
Montreal, Quebec, Canada
E-mail: jake.barralet@mcgill.ca
Member-at-Large (Quebec): Mircea-Alexandru Mateescu
Université Du Quebec
Montreal, Quebec, Canada
Email: mateescu.m-alexandru@uqam.ca
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CRS Chapter Report Hawaii 2013 – Canada Chapter
Member-at-Large (Maritimes): Amyl Ghanem
Dalhousie University
Process Engineering and Applied Science
Halifax, Nova Scotia, Canada
Email: amyl.ghanem@dal.ca
Webmaster: Marta Cerruti
McGill University
Materials Engineering
Montreal, Quebec, Canada
E-mail: marta.cerruti@mcgill.ca
Meeting Coordinator: Marc Thibault
Ecole Polytechnique
Department of Chemical Engineering
Montreal, Quebec, Canada
E-mail: marc.thibault@polymtl.ca
Student Board Members:
Patricia Comeau - Publications
Dalhousie University
Email: tacomeau@gmail.com
Scott Campbell - Assistant Secretary
McMaster University
Email: campbesb@mcmaster.ca
Total number of chapter members: 208
2012-2013 Chapter Activities:
o Event name (1): 2012 Canadian Micro-Computed Tomography Workshop
Event dates: June 12-14, 2012; University of Alberta, Edmonton, Alberta Canada
o Attendee total: 40
o Event Highlights: The Canadian CRS chapter partnered with the micro-CT imager
manufacturer Bruker-Skyscan in order to convene a 3-day workshop. The workshop
included formal podium presentations, poster sessions and hands-on interactive
scanning sessions and computer labs to increase participants micro-CT skill levels.
New chapter members were signed.
o Sharing Success: The Chapter had a CRS membership booth on-site, with our
Chapter banner, promotional materials and staffed by graduate students at all times.
New members were recruited, and advertising was available regarding both local
chapter events as well as the upcoming Annual Meeting & Exposition of the
Controlled Release Society.
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CRS Chapter Report Hawaii 2013 – Canada Chapter
o Event name (2): Workshop on Ocular Drug Delivery ("Preserving and Enhancing
Vision via Ophthalmic Drug Delivery" – held at the 2012 Annual Meeting & Exposition,
Quebec City, Canada.
o Event date: Sunday July 15, 2012
o Attendee total: 30
o Event Highlights: The Canadian CRS chapter organized its first Workshop as part of
the CRS national meeting & exposition. That workshop brought together industrial
researchers, clinicians, and research scientists to discuss the current state-of-the-art
technology in ophthalmic drug delivery (at both the front and the back of the eye) and
the opportunities and challenges for future developments. The event was attended by
over 30 conference participants.
o Sharing Success: The Canadian CRS chapter continues to increase its involvement
with our CRS parent body.
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Event name (3): CC-CRS/CSPS Montreal Fall Networking Event
Event date: Tuesday October 30, 2012; Montreal, Quebec Canada
Attendee total: 60
Event Highlights: The Canadian CRS held a joint Networking Event with the Canadian
Society for Pharmaceutical Sciences in Montreal on October 30. Attendees were
privileged to hear talks given by Prof. Dusica Maysinger (McGill University;
Experimental Medicine) on the topic of “Microglia; The Unsung Heroes”, and Dr.
Stephen J. Klein (IRICoR) on the subject of “IRICoR; A New Model of Partnership
with The Biopharmaceutical Sector”. This event was well attended by CC-CRS
members and further provided a social forum for interacting with local industrial
representatives after the talks.
o Sharing Success: Linking academia with local industry! The meeting event gave us
the opportunity to invite and interact with several local industrial speakers. It also
served as a forum to welcome many new members to the Canadian CRS Chapter,
who joined that evening and in the days that followed.
o Event name (4): Chapter Presentation at the University of Calgary, Alberta Canada
o Event date: Wed May 1, 2013
o Event Highlights: The first Canadian CRS chapter event took place at the University
of Calgary. Reaching out to the Biomedical Engineering community there, President
Dr. Mike Doschak outlined the fit of drug delivery from engineered biomedical devices
and was successful with the first CRS Chapter memberships at that institution.
o Event name (5): 2013 Annual Meeting of the Canadian Chapter of CC-CRS
Title: “Personalized Medicine and Individualized Drug Delivery”
o Event date: University of British Columbia, Vancouver, Canada; June 11-14, 2013
o Attendee total: 300
o Event Highlights: The Canadian CRS continues to partner with the Canadian Society
for Pharmaceutical Sciences (CSPS) to hold an Annual Conference. . The Canadian
chapter of CRS will be organizing 2 consecutive academic sessions on the topics of
“Protein Drug Delivery Systems and Devices” and “Nanomedicine and Gene
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CRS Chapter Report Hawaii 2013 – Canada Chapter
Delivery”. The session chairs will be tasked with announcing the upcoming 40th
Annual Meeting & Exposition of the Controlled Release Society, to be held July 2124, 2013 at the Hawaii Convention Center, Honolulu, Hawaii, U.S.A. That meeting
schedule is attached and the Canadian Chapter organized 2 sessions highlighting the
name and work of the CRS.
o Sharing Success: As we are partnering with a like-minded academic societies to cohost the event, we attract a portion of their membership to the CRS academic
sessions (2 concurrent sessions planned), and further sign them up as members at
our dedicated CRS chapter booth. The meeting further serves to bring together the
national membership of our chapter from distant provinces, in order to hold our
Annual General meeting.
2014 (future) Chapter Activities:
o Planned event name:
2014 Annual Meeting of the Canadian Chapter of CC-CRS
o Planned event dates: May 2014, Montreal Quebec
Chapter’s involvement with CRS
o teleconferences and CRS annual conference
The Canadian CRS Chapter participates in the CRS chapter teleconferences, when
possible.
o
publication in the CRS newsletter
The Canadian CRS Chapter continues to provide written materials of upcoming
chapter events to the CRS Capsule.
Report submitted by Michael Doschak (Canada Chapter President, 2011-13).
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B
ruker and SOQUELEC representatives, as well as researchers from
across Canada, gathered at the University of Alberta to attend the first
Canadian Skyscan Users’ Meeting (CA-SUM). The meeting, hosted by the
laboratory of Honorary CA-SUM President Dr. Michael Doschak, lasted for
two days, from June 12th to June 14th.
O
ver the course of three days, the CASUM users meeting showcased the cutting-edge research of several laboratories at
universities all over Canada, as well as the implementation of SkyScan Micro-CT technology. The first day of the conference consisted
of presentations by Skyscan users sharing their
successes in applying Skyscan technology.
Presentations selected were invited for a free
three night stay at the Crowne Plaza Chateau
Lacombe, overlooking the River Valley.
P
articipants were served a delicious catered lunch and then shown the four Skyscan Micro-CT scanners on campus. They
were guided to Biological Sciences and the
Centennial Centre for Interdisciplinary Sciences (CCIS) to see the ex-vivo scanners: the
Skyscan 1174 in Dr. Alison Murray’s laboratory, the Skyscan 1176, owned by Dr. Murray
Gingras. Lionel Wolniewicz from Soquelec
and Dr. Phil Salmon from Bruker-Skyscan
presented both ex-vivo scanners.
1) 2) and 7) Lionel Wolniewicz and Phil Salmon present the 1174 and 1172 in-vivo scanners, owned by Dr. Allison Murray and
Dr. Murray Gingras respectively. In 3), 4), 5) and 6) Dr. Michael Doschak, Dr. Andre Rochon, Marinne Cotineau, and Dr.
David Cooper present their research, specifically pertaining to their usage of Skyscan Micro-CT technology.
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Interactive Scanner sessions 1172 @ CCIS Building + 1176 @ KATZ Building
1172/1174 Session
1176 Session
@ CCIS Building, Meet in south lobby, upon Quad
@ Katz Building East, Meet in room 2‐003
1:15 PM
Part A
Break (time for rotation) 3.00‐3.15 pm
Part B
5:00 PM
Groups will be
announced during the
meeting. We will try to
respect every
participant choices.
@ Wildflower Restaurant
Dinner 7 pm: Rendez-vous at WildFlower Restaurant
Wednesday 13
CTan workshop 9.00 am:
@ ECHA Building - L1 250 (lower basement-level floor)
1st part (http://www.labs.ualberta.ca/locations/building.html?id=108)
10.45-11.00 am: Coffee break + poster viewing @ ECHA Building – L1 190
11.00 am:
2nd part
1.00 - 2.00 pm: Lunch
Award ceremony + closing speech 2.00 pm:
@ ECHA Building – 1 190 (main floor)
Poster Challenge Awards
2.30-3.00 pm: Closing Speech (Bruker-SkyScan + Soquelec)
3-6 pm:
Facilities available to conduct additional scans or CTan analysis
Thursday 14
Jasper National Park tour •
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Departure at 7 am from the hotel entrance, Crowne Plaza – Chateau LaCombe.
Visit in the park, lunch in the park.
Maligne Lake 90 minute boat cruise available (Adult: 55.00, Youth: 27.62) (or free time) in the afternoon.
http://www.malignelake.com/
Dinner in Jasper at 5:00 pm.
Return by 10:00 pm
Coach sponsored by:
Canadian Chapter of the Controlled Release Society,
http://www.cc-crs.com/
Osteometabolix (OMX) Micro-CT Imaging services,
http://www.osteometabolix.com/
W
ednesday morning began with the CT-An workshop, where Jeroen Hostens and Phil
Salmon gave an overview on Post-Scanning image processing software. Participants
were guided through the inner workings of the DataViewer, CT-Analyzer and CT-Vox programs, used for image analysis and 3D rendering, respectively. The workshop lasted all morning, and gave participants a chance to try out data processing and analysis.
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1) and 2) Phil Salmon explains the functions of DataViewer and CTAn respectively. 3) Participants follow along with Jereon
and Phil’s presentations. 4) Michael Sullivan, from McGill University, explains his poster to Jereon Hostens.
A
fter having lunch, the winner of the poster presentation competition, Dominique Behrends
from McGill University, was awarded an IPad. Dr. Doschak and Lionel Wolniewicz of
from Soquelec gave closing speeches and ended the meeting.
At 7:00 AM the next morning the tour of the beautiful Jasper National Park began! We departed
by Greyhound from Edmonton and drove about four hours westward. At noon the busses arrived in the town of Jasper for a brief stop before departing once more. After an hours drive, we
arrived at the scenic Maligne Lake, and some participants took a boat tour of the lake as well as
Liberty Island.
1) Maligne Lake, still a very scenic view despite the overcast weather. 2) Jasper National Park, the largest national park in the
Canadian Rockies, includes the Miette Hot Springs, and Columbia Icefields, as well as a lot of Wildlife. 3) The town of Jasper
is a specialized municipality and the commercial centre of the park. 4) A mule deer. Deer, Elk and Bears are very common
throughout Jasper.
A
fterwards, we were bussed off to the Miette hot springs, the final stop on our journey before boarding the bus and heading home, and the first annual CA-SUM meeting was over!
Thank you to all who attended and participated!
Pictures taken by Yuchin Wu
Report by Nelson Cao
Rev. 2013Jun7
Conference Program
TUESDAY, JUNE 11, 2013 (Room 1101 Pharmaceutical Sciences Building, UBC) Time Event Speaker
7:00 AM 8:00 AM Title
Registration and Coffee/Tea PLENARY LECTURE 1: Dan Roden, Vanderbilt University Engineering a Healthcare System to Deliver Personalized Medicine Ronnie Miller Graduate Scholarship in Personalized Medicine, presented by Dr. Roger Brownsey, Faculty of Medicine, UBC, Ronnie Miller, President & CEO, Roche Canada, and John Willow, BC Director, Rx&D
9:00 ‐
12:00 NOON INDUSTRY‐SPONSORED WORKSHOP I Personalized Medicine: The Pharma Perspective ‐ Engaging the Community Chair: Robert Young, Simon Fraser University Ronnie Miller, Roche Pharmaceuticals
The Role of Personalized Heath Care in Driving Canada’s Economy
Rav Kumar, GlaxoSmithKline Canada
Making Canada a Powerhouse in Pharmaceutical R&D in the New World of Personalized Medicine Fred Van Goor, Vertex Pharmaceuticals Science and Challenges Behind the Personalized Medicine Canada Approach with Kalydeco
Refreshment and networking break Simon Pimstone, Xenon Pharmaceuticals
Drug Target Selection: Lessons from Human Genetics
Richard Cheung, Fasken Martineau DuMoulin Karimah Es Sabar, Centre for Drug Research and Development Brad Popovich, Genome BC Personalized Medicine: A Legal and Regulatory Perspective
Transforming Discovery into Opportunity: The CDRD Bridge Between Industry and Academia Genome BC: Regional Perspectives on Personalized Medicine in British Columbia, Canada
Roundtable Discussion Lunch and networking break (box lunches) 12:00‐1:00 INDUSTRY‐SPONSORED WORKSHOP II 1:00 ‐ 2:30 Personalized Medicine: The Diagnostic/ Information Technology Company Perspective PM Chair: Pieter Cullis, University of BC
Alex Yong, Illumina Companion Diagnostic Partnership with Illumina
Frederick Lee, Oracle Paul Kearney, Integrated Diagnostics
James Taylor, Precision NanoSystems
2:30‐3:00 Rev. 2013Jun7
Big Data Analytics Accelerating the Emergence of Personalized Healthcare
The Development and Validation of High Value Molecular Diagnostics Intended for Clinical Use: A Case Study in Lung Cancer
The NanoAssemblr ‐ A Platform for the Translation of Genomic Information from Bench to Bedside Refreshment and networking break TUESDAY, JUNE 11 (Room 1101 Pharmaceutical Sciences Building, UBC) 3:00 ‐ 5:30 PM INDUSTRY‐SPONSORED WORKSHOP III Personalized Medicine: The Biotech Perspective Chair: Ron Boch, BIOTECanada, Ottawa
James Mansi, Novartis Pharmaceuticals Canada Ali Tehrani, Zymeworks Nathan Yoganathan, Kalgene Scott Patterson, Amgen Russell Weiner, Merck Christopher Jowett, Abbott Molecular
Panel Discussion 6:00 to 7:30 PM Fostering Effective Industry, Public Health, Academic Collaborations ‐ Optimising health Care Interventions Towards Improving the Health of Canadians Zymeworks – Designing Bispecifics and other Next‐Generation Protein Therapeutics
Pathways to Personalized Medicine Translational Biomarker Research in Drug Development: Challenges and Opportunities
Successful Implementation of Global Biomarker Strategies: Pre‐Analytics Matters (But is Often Ignored) Companion Diagnostics Success from Biomarker Discovery to Global Commercialization
Industry‐sponsored Networking, Welcome Reception, and Poster Viewing ‐ Poster Session 1 WEDNESDAY, JUNE 12 ‐ MORNING Time Event/ Speaker 7:00 to 8:00 AM Title Event Speaker
Title Registration and Coffee/Tea and Poster Set‐Up 8:00 to PLENARY LECTURE 2: Buddy Ratner, University of Washington 9:00 AM The Personalized Medicine/Tissue Engineering/Cancer/ Drug Delivery Intersection (Room 1101 Pharmaceutical Sciences Building) SESSION 1: Personalized Medicine and Cancer Chair: David Huntsman, BC Cancer Agency (Room 1101 Pharmaceutical Sciences Building) SESSION 2: Protein Drug Delivery Systems and Devices Co‐Chairs: Michael Doschak, U of Alberta & Brian Amsden, Queen's U (Room 1201 Pharmaceutical Sciences Building)
9:00 David Huntsman, Genomic Driven Personalized Robert Farra,
UBC/BC Cancer Agency Cancer Control: Ready to Hit MicroCHIPS the Runway? 9:30 Sohrab Shah, UBC/ BC Cancer Agency 10:00 Rev. 2013Jun7
Evolutionary Dynamics of High‐grade Serous Ovarian Cancers: Implications for Personalized Medicine
Mark Tomai, 3M Drug Delivery Systems Enabling Remote Medicine: Implantable, Wirelessly‐
Controlled Microchip Drug Delivery Intradermal Delivery of Small Molecules, Proteins, Peptides and Vaccines using Microneedle Technologies
Refreshment and networking break and poster viewing ‐ Poster Session 1 WEDNESDAY, JUNE 12 ‐ MORNING (Cont'd) 10:30 11:00 11:30 ‐
12:10 Christian Steidl, UBC/BC Cancer Agency Lymphoma Genomics: Diagnostic Precision Tools for Guiding Treatments
Poul Sorensen, UBC/BC Functional Validation: Linking Cancer Agency Genomic Alterations to New Treatment Opportunities
Robert Gurny, University of Geneva The Challenges of Protein and Peptide Delivery Brian Amsden, Queen's University Formulation Strategies Around Osmotically‐driven Therapeutic Protein Release
CSPS Lifetime Achievement Award Lecture: John McNeill, Faculty of Pharmaceutical Sciences, UBC Fructose Ingestion, Hypertension and the Metabolic Syndrome (Room 1101 Pharmaceutical Sciences Building)
12:10 to 2:00 PM Lunch break, networking and poster viewing ‐ Poster Session 1 WEDNESDAY, JUNE 12 ‐ AFTERNOON 2:00 to PLENARY LECTURE 3: Lawrence Lesko, University of Florida 3:00 PM A Landscape Analysis of Pharmacogenomics (Room 1101 Pharmaceutical Sciences Building) 3:00 3:30 SESSION 3: Personalized Medicine and Pharmacogenomics Chair: Bruce Carleton, BC Children’s Hospital (Room 1101 Pharmaceutical Sciences Building) Bruce Carleton, BC The Two Pharmacos: Children's Hospital Vigilance and Genetics ‐ A Powerful Partnership to Improve the Safe Use of Drugs Richard Kim, University Implementation of of Western Ontario Personalized Medicine (PM): From PM Clinics to Inpatient Care 4:00 SESSION 4: Nanomedicine and Gene Delivery SPONSORED BY: NORTHERN LIPIDS Co‐Chairs: Larry Unsworth, U. of Alberta, & Emmanuel Ho, U of Manitoba (Room 1201 Pharmaceutical Sciences Building)
Emmanuel A. Ho, University of Manitoba Intravaginal Delivery of siRNA as Potential Microbicides Michael Buschmann, École Polytechnique Nucleic Acid Delivery using Chitosans Refreshment and networking break and poster viewing ‐ Poster Session 1 4:30 Richard Weinshilboum, Breast Cancer Mayo Clinic Pharmacogenomics: Beyond Biomarkers Larry Unsworth, University of Alberta 5:00 Colin Ross, UBC Suzie Pun, University of Washington 5:30 to 7:00 PM 6:30 PM Development of Novel Tools for Personalized Genomic Medicine to Improve Drug Safety in Children
Networking and Poster Viewing ‐ Poster Session 2 CSPS Board of Directors Meeting (Room 3110 Pharmaceutical Sciences Building) Rev. 2013Jun7
Programming Biomaterials for Personalized, On‐
Demand Medicine: A Nanomedicine Approach
Peptide‐Targeted Polycations for Nucleic Acid Delivery