Institut Pasteur: health research and
intervention world-wide
Paul Brey
Japan Science and Technology Forum
5 October 2007
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Institut Pasteur ’s creation
1887: Established by international fund raising (Russia, Brazil,
Japan, France) following L. Pasteur’s Rabies vaccine success
« Our institute will be both a health center for treating rabies, a
research center for infectious diseases and a learning center »
Louis Pasteur
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Institut Pasteur and Japan :
a long lasting relationship
• In 1886, when Pasteur raised funds to
create the Institute, the personnel from
a company from Yokohama participated
• The first Japanese student in the
Silk worm
microbiology course was Dr Yabe, in
1897
• In 1922, for centennial of Pasteur’s
birth, Japan donated 2 magnificent
vases. They now are in
the crypt, where Pasteur is buried.
•In 2005, the creation of the
Association Pasteur Japon
To help promote Institut Pasteur in
Japan
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Institut Pasteur
The founding vision of Institut Pasteur is to improve human health and
welfare through scientific discovery.
Challenge Today: is to translate this vision into twenty first century science and
technology within a complex global framework confronted with environmental change,
emerging infectious disease and non-infectious diseases. Aim: is to is to continue to
improve human health and welfare through scientific discovery by having a better
understanding of the underlying mechanisms of environmental change on pathogens and
their reservoirs as related to their mode of transmission, persistence and adaptation to
humans. To integrate the most cutting edge technologies along with traditional natural history
studies on pathogens, as well as to better understand the mechanisms leading to cancer and
neurological diseases.
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Institut Pasteur in 2007
• Research
Study of infectious diseases, immune, genetic and neurological
diseases for both prevention and cure.
• Public health
Reference Centers, WHO Collaborating Centers, Outpatient Medical
center
• Education and training
1,100 students and trainees from 63 Countries
• International Network
30 Institutes on 5 continents
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Institut Pasteur in 2007
A PRIVATE FOUNDATION
Public Funding
Donations & Legacies
32%
33 %
35 %
Business Development : fees, royalties, expert appraisals
Annual budget (2006): 217 M €
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Biomedical Research
and Public Health
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Institut Pasteur: Research
130 laboratories
20 cutting-edge core facilities
Genomics and Proteomics, Microarrays,
Molecular Cryo-microscopy, TEM, Dynamic Imaging, etc.
More than half of research is devoted to infectious diseases
Increasing efforts on neglected and emerging diseases.
New labs and projects: Viruses (Avian Flu, Chik, …), Malaria,
Leishmania, Trypanosoma, Buruli ulcer
Institut Pasteur: biomedical research
Global Health and infectious diseases
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Viral diseases
AIDS, Flu, dengue, rabies, hepatitis,
poliomyelitis, yellow fever, SARS,
haemorrhagic fevers,...
Bacterial diseases
Tuberculosis, enteric diseases, plague,
whooping cough, meningitis, anthrax,
resistance to antibiotics,...
Parasitic diseases
Malaria, leishmaniasis, amibiasis, Chagas
disease, sleeping sickness...
Fungal diseases
Cryptococcosis, candidiasis, aspergillosis,...
Institut Pasteur: biomedical research
y Cancers, genetic diseases
y Neuroscience and Neurodegenerative disease:
autism, deafness, Alzheimer’s
y Development of heart muscle
y Genomics and post- genomics
y etc...
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Institut Pasteur
Technology transfer
¾Vaccines
¾Diagnostic tests
¾Drugs
¾Environment
¾Incubator for startup companies several successful
IPOs
Public Health
Services
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National Reference and WHO
Collaborating Centers
20 Reference Centers and 8 WHO Collaborating Centers
monitor epidemics; provide technical advice at the
national and international level.
For example : WHO reference center for Influenza and
Rabies…
CIBU : emergency intervention unit for unknown pathogens
on call 24 hours, 7 days/week, 365 days/year
For example : SARS outbreak in China and Vietnam
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The Medical Center
ya Center for international
vaccination and travel medicine
yan outpatient clinic, including
tropical medicine, dermatology,
parasitology, mycology and
allergic reactions
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International
collaborations
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The International Collaborations
• To strengthen the scientific relations with
the other international organizations
• To develop projects in partnership with
other foundations or international actors:
World Health Organization (WHO)
GAVI (Global Alliance for Vaccines and Immunization)
Bill & Melinda Gates Foundation
DNDi (Drugs for Neglected Diseases initiative)
Bellagio Forum
Wellcome Trust - Oxford Tropical Medicine Unit
U.S. Department of Health and Human Services
• To promote the development of regional
poles : Asia, Europe, Africa, Middle-East, Latin
America
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Scientific collaborations JapanInstitut Pasteur in 2007
1. Collaborations with RIKEN
• Center for Developmental Biology, Kobe
• Research Center for Allergy & Immunology (RCAI),
Yokohama
• RIKEN Tsukuba
• Research Institute for Microbial diseases (BIKEN),
Osaka
• Brain Science Institute (BSI), Wako
2. Osaka University
3. Tokyo University (IMSUT)
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Institut Pasteur International
Network
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Origin of the International Institut
Pasteur Network
Three years after the establishment of
Institut Pasteur in Paris, Louis Pasteur
decided to establish Institut Pasteur
outside of metropolitan France sending
his most talented young scientists to
vaccinate populations against rabies and
smallpox and to study infectious diseases
“The future belongs
to those who help
suffering humanity”
Louis Pasteur
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Le Réseau International des
Instituts Pasteur
In 1891, Albert Calmette founded the first
Institut Pasteur outside of metropolitan
France in Saigon
Today the network
includes 30 institutes
spanning five
continents.
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The International network of
Pasteur Institutes
30 Institutes
Institut Pasteur Laos 2009
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Institut Pasteur International
Network
Missions
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•
•
•
•
•
•
Public Health
Research
Teaching & Training
Services
Vaccine Production
Technology transfer
¾ To improve research capacity
¾ To improve the public health in
the countries where these
institutes are located
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Health and Sustainable development
A few examples of activities and programs addressing global
health challenges
• Avian flu diagnosis and surveillance (Cambodia, Laos,
Vietnam and China)
• Development of rapid diagnosis “dip-sticks” for plague,
cholera, meningitis (IPs in Africa)
• Distribution of bed nets and malaria surveillance
• Remote Sensing Surveillance studies to help predict
outbreaks of Vector borne and Avian borne diseases
• Food safety and Environmental hygiene
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Institut Pasteur
Network in ASIA
Instituts Pasteur in Asia
• Korea
• Shanghai
• Hong-Kong
• Vietnam
• Cambodia
• Laos
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Institut Pasteur of Korea
Created in 2003
Staff : up to 250 people
RESEARCH :
• Cancer, hepatitis, inflammation
• Therapeutics targets (malaria, AI)
• Enabling technology development
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Synergies between:
•IP Paris: competence in Biological research & Therapy
development and
•IP Korea: competence in Information technology, Robotics,
Nanotechnology, Enabling Technology/Research & Development
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Institut Pasteur de Shanghai
/Chinese Academy of Sciences
Created in 2004
Staff : up to 160 people
RESEARCH :
• Virology : Emerging viral
diseases : SARS, bird flu,
HIV/AIDS, hepatitis
• encephalitis, hemorrhagic
fevers
• Immunology
• Epidemiology
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Hong-Kong University - Pasteur
Research Centre
Created in 2000
Staff : 20 people
RESEARCH :
• Emerging viral diseases:
SARS, bird flu
•Hepatitis C & HIV
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Instituts Pasteur in Vietnam
IP Saigon 1891 (A. Calmette)
IP Nha Trang 1895 (A. Yersin)
IP Hanoi 1926 (N. Bernard) -> NIHE
Staff : >500 people Vietnamese Ministry
of Health
RESEARCH :
• Prevention and treatment of infectious
diseases
• Emerging viral diseases: SARS, Avian
Influenza (H5N1), Encephalitis
•Bacterial diseases
•Dengue Fever/Medical Entomology
• Hepatitis C HIV/AIDS
•Vaccine production
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Institut Pasteur of Cambodia
Created in 1927
Staff : 100 people
RESEARCH :
• Prevention and treatment of infectious
diseases
• Emerging viral diseases: SARS, bird flu
• HIV/AIDS
•Dengue
•Mycobacterium spp. Infections
•Malaria
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Institut Pasteur Laos within Lao National Biomedical Campus
z IP Laos is a Lao National Research
Institute
z Research mandate on Emerging
Viruses, Vector-Borne Disease and
Environmental Impact on Human
Disease
z Institut Pasteur Laos is funded by
Institut Pasteur and the International
Donor Community: European
Commission, Luxembourg
Government, French Government,
Asian Development Bank.
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Institut Pasteur Network in Asia
Installation of Level 3 Bio-security laboratories
in IP Network Institutes in Asia:
Installation of BSL3
facilities provides necessary
bio-security to identify and
investigate
dangerous
infectious agents
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A task force on severe acute respiratory
infections and emerging viruses
Objectives :
1/ Novel diagnostics tools for Acute Respiratory
Infections
2/ Surveillance, identification, characterization and
epidemiology of newly emerging viruses
in human populations
3/ New antiviral drugs
4/ New candidate vaccines
5/ Teaching and training
Instituts Pasteur Paris, Cambodia, Korea,
Hong Kong, Shanghai, Vietnam, Laos,
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Research-driven Response to Acute
Respiratory Infections”, acronym RESPARI.
•This research program aims to study
the following aspects of acute
respiratory infections (ARI) of viral
origin (H5N1, SARS etc.)
•(1) standardized diagnosis and surveillance
in humans and animals
• (2) epidemiology & natural history of
infectious agents (Risk Factors, Reservoirs,
Modes of Transmission).
• (3) the development of new diagnostic
tools, based on biotechnologies (pseudoparticles, quantum dots, molecular beacons)
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IP Network is reinforcing Avian
Influenza research in the region
•Cambodia, Laos, Vietnam and
China
• REINFORCING
DIAGNOSTICS, SURVEILLANCE
& RAPID RESPONSE
Ability to detect and contain an outbreak at the source
•DATA COLLECTION / DATA MANAGEMENT /
H5N1 SAMPLE SHARING/DATA SHARING
Working closely with Regional Ministries of Health and
WHO for Data Collection/ Data Management and Data
and Sample sharing.
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IP Network is reinforcing Avian
Influenza research in the region
•Cambodia, Laos, Vietnam and
China
•ENHANCING RESEARCH CAPACITY
BUILDING
We are actively participating in capacity building throughout the region through training and participative research
projects not just sample collection.
•PUBLIC AWARENESS
IP Network encourages media campaigns to improve public
awareness
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Putative Biotechnological Applications may be
derived from IP Network RESPARI program
•National Institute of Hygiene and Epidemiology, (NIHE) Hanoi
in collaboration with IMSUT Tokyo University
•Institut Pasteur Ho Chi Minh City (IPHCMC)
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Vaccine Production
AI H5N1
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Biotechnological Applications derived from IP
Network RESPARI program
• Institut Pasteur Shanghai (IPS)
- RAPID DIAGNOSTICS
- DRUG SCREENING
• Centre Pasteur at Hong Kong University (HKU-PRC)
• Institut Pasteur Korea (IPK, South Korea)
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Avian Influenza A H5N1
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Teaching and Training
worldwide
Teaching and training
Institut Pasteur has always been a pioneer in teaching new
scientific disciplines
1889 : First course on Microbiology
Today : 12 Master’s courses every year
800 students and interns
from over 60 countries are
trained each year in the
Institute laboratories.
Teaching and capacity building
Training and teaching of personnel within Institut
Pasteur Network
Examples of courses in 2006-2007
• Pasteur-Asia Virology Course :HKU-Pasteur,Hong-Kong
• Malaria course : Institut Pasteur Madagascar
• Bio-Safety
and
BSL3
level
pathogenic
Institut Pasteur Shanghai
• Bioinformatics Institut Pasteur Dakar
• Rabies Diagnostics Institut Pasteur Ho Chi Minh City
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agents:
Institut Pasteur : 2008-2011
In 2008 : celebration of 120 years of
Institut Pasteur
In 2009 : Institut Pasteur Laos operational
In 2010-2011 : project to create a new
research center devoted to:
« Integrative Biology of Emerging Diseases »
www.pasteur.fr
www.pasteur-international.org
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