Material Safety Data Sheet
EMERGENCY NUMBERS:
(USA) CHEMTREC : 1(800) 424-9300 (24hrs)
(CAN) CANUTEC : 1(613) 996-6666 (24hrs)
(USA) Anachemia : 1(518) 297-4444
(CAN) Anachemia : 1(514) 489-5711
WHMIS
Protective Clothing
TDG Road/Rail
WHMIS CLASS: E D-1A B-6 F
TDG CLASS: 8
PIN: UN1810 PG: II
Section I. Product Identification and Uses
Product name
PHOSPHORUS OXYCHLORIDE
CI#
Not available.
CAS#
10025-87-3
Chemical formula
POCl3
Synonyms
Phosphorus oxytrichloride, Phosphoryl trichloride, Code
Trichlorophosphine oxide, Trichorophosphorus oxide,
AC-7454, 70196
Formula weight
Supplier
Anachemia Canada.
255 Norman.
Lachine (Montreal), Que
H8R 1A3
Material uses
For laboratory use only.
AC-7454
153.35
Supersedes
Section II. Ingredients
Name
CAS #
%
TLV
1) PHOSPHORUS OXYCHLORIDE
10025-87-3
100
Exposure limits: ACGIH TWA 0.1 ppm
(0.63 mg/m3)
Toxicity values of the
hazardous ingredients
PHOSPHORUS OXYCHLORIDE:
ORAL (LD50): Acute: 36 mg/kg (Rat). 327 mg/kg (Mouse).
VAPOR (LC50): Acute: 48 ppm (Rat) (4 hour(s)). 53 ppm (Guinea pig) (4 hour(s)).
Section III. Physical Data
Physical state and
appearance / Odor
pH (1% soln/water)
Colorless to pale yellow liquid. Pungent irritating odor.
Odor threshold
Not available.
Percent volatile
100% (V/V)
Freezing point
1.17°C
Boiling point
105 to 109°C
Specific gravity
1.68 at 60/60°C (Water = 1)
Vapor density
5.3 (Air = 1)
Vapor pressure
35 (104) mm of Hg @ 25°C (50°C)
Water/oil dist. coeff.
Not available.
Evaporation rate
Not available.
Solubility
Reacts violently with water.
PHOSPHORUS OXYCHLORIDE
page 2/4
<7
Section IV. Fire and Explosion Data
Flash point
Not applicable.
Flammable limits
Not applicable.
Auto-ignition temperature Not applicable.
Fire degradation
products
Phosphorus oxides, phosphine, hydrogen chloride, chlorine.
Fire extinguishing
procedures
Use dry chemical powder or carbon dioxide. Moisture reactive material. DO NOT use water. Wear adequate personal
protection to prevent contact with material or its combustion products. Self contained breathing apparatus with a full
facepiece operated in a pressure demand or other positive pressure mode. Move containing vessels from fire if without
risk.
Fire and Explosion
Hazards
Moisture reactive material. Reacts violently with water. Flammable/explosive hydrogen gas may be formed upon
contact of this product with metals in the presence of moisture. Contact with water gives off toxic, highly flammable
gas. Do not allow water to get inside container because of violent reaction. Container explosion may occur under
fire conditions or when heated. Contact with other material may cause fire and/or explosion. When heated to
decomposition it emits highly corrosive and highly toxic fumes. The sensitivity to static discharge is not available.
The sensitivity to impact is not available.
Section V. Toxicological Properties
Routes of entry
Ingestion and inhalation. Eye contact. Skin contact.
Effects of Acute
Exposure
May be fatal by ingestion, inhalation, or by skin absorption. Corrosive. Target organs: liver, kidneys, eyes, skin,
respiratory system, lungs, central nervous system.
Eye
Skin
Vapors, liquids and mists are extremely corrosive to the eyes. Brief contact of the vapors will be severely irritating. Brief
contact of the liquid or mist will severely damage the eyes and prolonged contact may cause permanent eye injury which
may be followed by blindness. Lachrymator.
Liquid is extremely corrosive to the skin and rapidly cause severe chemical burns. May cause sensitization by skin
contact. Readily absorbed through skin.
Inhalation
Highly toxic. Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract.
Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical
pneumonitis and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, laryngitis,
dyspnea, headache, nausea, vomiting, dizziness, bronchopneumonia, and nephritis. Can cause liver, kidney, and
lung damage. May cause delayed lung injury.
Ingestion
Highly toxic. Burns in mouth, pharynx and gastrointestinal tract. May cause nausea, vomiting, abdominal pain,
dysphagia, edema and possibly death. See inhalation. If a small amount of the liquid is aspirated into the lungs, very
severe lung damage or death could result.
Section V. Toxicological Properties
Effects of Chronic
Overexposure
PHOSPHORUS OXYCHLORIDE
page 3/4
Erosion of the teeth and jaw. Can cause liver, kidney, brain, bone, and lung damage. Exposure may cause asthma,
dermatitis, conjunctivitis, bronchitis and pulmonary oedema; effects may be delayed. Carcinogenic effects: Not
available. Mutagenic effects: Not available. Teratogenic effects: Not available. Toxicity of the product to the
reproductive system: Not available. To the best of our knowledge, the chemical, physical, and toxicity of this substance
has not been fully investigated. Medical conditions which may be aggravated: Individuals with preexisting diseases of
the skin, eye, or respiratory system may be more susceptible to the toxicity of overexposure to this product.
Section VI. First Aid Measures
Eye contact
Immediate first aid is needed to prevent eye damage. Washing within 1 minute is essential to achieve maximum
effectiveness. IMMEDIATELY flush eyes with copious quantities of water for at least 15 minutes holding lids apart to
ensure flushing of the entire surface. If irritation persists, repeat flushing. Get prompt medical attention, perferably
from an opthamologist.
Skin contact
Immediate first aid is needed to prevent skin damage. Immediately flush skin with plenty of water and soap for at
least 15 minutes while removing contaminated clothing and shoes. Seek immediate medical attention. Discard
contaminated clothing and shoes.
Inhalation
Remove patient to fresh air. Administer approved oxygen supply if breathing is difficult. Administer artificial respiration
or CPR if breathing has ceased. Seek immediate medical attention.
Ingestion
If conscious, wash out mouth with water. Have conscious person drink several glasses of water or milk. DO NOT
induce vomiting. If spontaneous vomiting occurs, have victim lean forward with head down to avoid breathing in of
vomitus, rinse mouth and administer more water. Never give anything by mouth to an unconscious or convulsing
person. Seek immediate medical attention. NOTE TO PHYSICIAN: There is no specific antidote. Treatment of
overexposure should be directed at the control of symptoms and the clinical condition of the patient.
Section VII. Reactivity Data
Stability
Unstable. Moisture sensitive! Conditions to avoid: High temperatures, sparks, open flames and all other sources
of ignition, contamination.
Hazardous decomp.
products
Hydrogen chloride, phosphine, phosphorus oxides, phosphoric acid.
Chlorure d'hydrogène, phosphine, oxydes de phosphore, acide phosphorique.
Incompatibility
Explosive/violent reaction with with water, alcohols, combustible materials, organic acids, moisture, acids, alkalis,
alkali metals (sodium, potassium, etc..), nitric acid, bases, ammonia, amines, dimethylsulfoxide, carboxylic acids
(acetic acid, etc..), aluminum, organic materials, powdered metals, carbon disulfide, dimethylformamide,
2,5-dimethylpyrrole, 2,6-dimethylpyridine n-oxide, pyridine n-oxide, zinc, ferrocene-1,1-dicarboxylic acid, phenols,
boron triiodide. Flammable/explosive hydrogen gas may be formed upon contact of this product with metals in the
presence of moisture. May attack some forms of plastics, rubbers and coatings.
Reaction Products
Readily hydrolyzed by moisture, with the liberation of hydrochloric and phosphoric acid. Corrosive to metals.
Reacts exothermicaly with water. Hazardous polymerization will not occur.
Section VIII. Preventive Measures
PHOSPHORUS OXYCHLORIDE
page 4/4
Protective Clothing in Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Wear disposable coveralls and
case of spill and leak discard them after use.
Spill and leak
Evacuate and ventilate the area. Stay upwind: Keep out of low areas. Absorb on sand or vermiculite and place in a
closed container for disposal. Wash spill site after material pick up is complete. DO NOT empty into drains. DO NOT
touch damaged container or spilled material. Avoid contact with a combustible material (wood, paper, oil, clothing...).
DO NOT direct water at spill or source. DO NOT get water inside container.
Waste disposal
Consult your local or regional authorities. According to all applicable regulations. Harmful to aquatic life at low
concentrations. Can be dangerous if allowed to enter drinking water intakes. Do not contaminate domestic or irrigation
water supplies, lakes, streams, ponds, or rivers.
Storage and Handling
Store in a cool place away from heated areas, sparks, and flame. Store in a well ventilated area. Store away from incompatible
materials. Do not add any other material to the container. Do not wash down the drain. Do not breathe gas/fumes/vapor/spray.
In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from direct sunlight or strong incandescent
light. Keep container tightly closed and dry. Manipulate under an adequate fume hood. May react in presence of moisture.
Never add water to this product. Empty containers may contain a hazardous residue. Handle and open container with care.
Take off immediately all contaminated clothing. Do not allow water to get inside container because of violent reaction. Avoid
contact with a combustible material (wood, paper, oil, clothing...). Store in a glass container. This product must be
manipulated by qualified personnel. Do not get in eyes, on skin, or on clothing. Wash well after use. In accordance with good
storage and handling practices. Do not allow smoking and food consumption while handling. Keep above freezing point. In
case of accident or if you feel unwell, seek medical advice immediately (show the label when possible.).
Section IX. Protective Measures
Protective clothing
Face shield and splash goggles. Impervious rubber gloves, apron, coveralls, and/or other resistant protective clothing. Sufficient to protect
skin. Have available and use as appropriate: rubber suits and boots. Wear appropriate MSHA/NIOSH approved chemical cartridge
respirator. If more than TLV, do not breathe vapor. Wear self-contained breathing apparatus. Do not wear contact lenses. Make eye bath
and emergency shower available. Ensure that eyewash station and safety shower is proximal to the work-station location.
Engineering controls
Use in a chemical fume hood to keep airborne levels below recommended exposure limits. Use adequate ventilation.
Ventilation should be corrosion proof. Do not use in unventilated spaces.
Section X. Other Information
Special Precautions or Corrosive! Highly toxic! Dangerously reactive material! Causes severe burns! Risk of
comments
serious damage to eyes. Possible risks of irreversible effects. Do not breathe vapor. Avoid
all contact with the product. Avoid prolonged or repeated exposure. Use in a chemical
fume hood. Reacts violently with water. Never add water to this product. Do not allow
water to get inside container because of violent reaction. Reacts violently with water,
liberating highly flammable gases. Contact with other material may cause fire and/or
explosion. Handle and open container with care. Container should be opened only by a
technically qualified person.
Synergistic materials: Not available.
RTECS NO: TH4897000 (Phosphorus oxychloride).
0
4
W
2
NFPA
Prepared by MSDS Department/Département de F.S..
Validated 15-Oct-2014
EMERGENCY NUMBERS:
(USA) CHEMTREC :
1(800) 424-9300 (24hrs)
(CAN) CANUTEC :
1(613) 996-6666 (24hrs)
(USA) Anachemia :
1(518) 297-4444
(CAN) Anachemia :
1(514) 489-5711
While the company believes the data set forth herein are accurate as of the date hereof, the company makes no warranty with respect thereto
and expressly disclaims all liability for reliance thereon. Such data are offered solely for your consideration, investigation and verification.