Brain Injury, September 2009; 23(10): 800–808 Hope, dispositional optimism and severity of depression following traumatic brain injury GIL PELEG1, OHR BARAK1,2, YERMI HAREL3,4, JUDITH ROCHBERG3, & DAN HOOFIEN2,5 Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. 1 The Tel-Aviv-Jaffa Academic College, Tel Aviv, Israel, 2The National Institute for the Rehabilitation of Persons with Brain Injuries, Tel Aviv, Israel, 3Loewenstein Hospital Rehabilitation Centre, Raanana, Israel, 4Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, and 5The Hebrew University of Jerusalem, Jerusalem, Israel (Received 7 April 2009; revised 8 July 2009; accepted 20 July 2009) Abstract Primary objective: To investigate the extent in which two coping variables—hope and dispositional optimism—are related to depression severity amongst individuals who have sustained traumatic brain injury (TBI). Methods and procedures: Sixty-five participants were administered the Beck Depression Inventory (BDI), the Adult Hope Scale (AHS), the Life Orientation Test-Revised (LOT-R) and a demographic and injury-related data questionnaire. In addition, relevant injury-related data was collected from the medical records. Main outcomes and results: High levels of depression were experienced in the study sample, while hope and dispositional optimism were significantly lower in comparison to the general population. The correlation patterns indicate that both hope and dispositional optimism negatively correlated with participants’ depression levels and that they showed significant positive correlations with each other. In the case of mild depression, the hope-Pathways sub-scale of the AHS was the only variable negatively correlated to it, while in moderate-to-severe depression all coping variables were negatively correlated to it. Regression analysis revealed that the AHS and LOT-R, but not the demographic and injury-related variables, predicted depression severity. Conclusions: Clinical implications in referring persons with TBI with mild vs. severe depression to rehabilitation programmes are discussed. Keywords: Adult Hope Scale, Beck Depression Inventory, depression, hope, Life Orientation Test Revised, optimism, traumatic brain injury Introduction The functional and psychological repercussions of traumatic brain injury (TBI) are diverse and can manifest in profoundly debilitating and wide ranged disabilities, which may affect the person’s every aspect of life. Mood disorders are among the most common post-TBI psychiatric disabilities [1]. Regardless of the severity of injury, individuals who have sustained TBI are at a high risk for the development of a mood disorder [2]. The prevalence of depression following TBI reaches significantly higher frequencies in comparison to traumatic injuries of comparable severity, but without involvement of the central nervous system [3], and it is certainly higher than in the general population [4, 5]. For example, Kreutzer et al. [5] found a 41.9% prevalence of major depressive disorder evaluated at an average of 2.5 years post-injury. Psychological reactions to the injury are the most probable aetiological derivations of the high Correspondence: Ohr Barak, Department of Behavioural Sciences, Tel-Aviv-Jaffa Academic College, 14 Rabenu Yerucham Street, Tel Aviv Jaffa 68182, Israel. E-mail: obar@mta.ac.il ISSN 0269–9052 print/ISSN 1362–301X online ß 2009 Informa Healthcare Ltd. DOI: 10.1080/02699050903196696 Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. Hope, optimism and depression in TBI depression rates among persons with TBI [3]. The disabilities and deficits following TBI force the recovering person to face many losses, be it the cognitive impairments, the functional disabilities or the loss of previous life fantasies and goals [6]. The coping strategies that were employed prior to the injury may no longer be available, which may exacerbate the difficulties [7]. These immediate and long-term losses are often followed by a period of mourning. The prolonged process of grief following TBI has been described as ‘partial death’, parts of the self that have lost their function but continue to exist as constant reminders of the past, thus causing a process of mobile mourning in which the grief continues indefinitely [8]. Many studies have demonstrated an association between major depression and poor psychosocial functioning and rehabilitation outcomes following TBI. For example, participants with prolonged major depression showed poor psychosocial and activities of daily living outcomes [9]. Even following mild TBI, participants with major depression had poorer outcome on the neurobehavioural rating scale and the Glasgow Outcome Scale than mild TBI participants without depression [10]. Despite these detrimental effects, depression is still inadequately conceptualized in the TBI population, as it represents a heterogeneous category comprised of multiple aetiologic and clinical implications. The present study explored the role of two coping variables that may elucidate aspects in depression severity following TBI. Hope is considered as one of the most crucial theoretical constructs to explicate a person’s way of coping with life’s challenges. It is described as an inner feeling that a problem will ultimately be solved or as the person’s evaluation of self-abilities to achieve goals [11]. In recent years a more holistic and integrated concept of hope has emerged [12, 13]. In addition to defining hope as the positive expectation of goal attainment, Snyder et al. [12, 13] expanded its definition to include two inter-related cognitive dimensions: agency and pathways. Agency refers to the person’s perceived inner resources which are required in order to proceed in a chosen path. Pathways refers to the possible routes a person is able to conceive while contemplating a desired destination; a person high in this element is characterized by the ability to conceive several alternative pathways. Arnau et al. [14] noted that the two dimensions of hope commonly, but not always, co-occur, indicating that both agency and pathways are necessary for the maintaining of hope. It was shown in numerous studies that high hope individuals had higher academic and sports achievements [for example 15, 16]. Hope has been found to be negatively related to general maladjustment [17] 801 and suicidal ideation [18] and it is also a crucial factor in dealing with major life stressors and traumas, such as cancer [19] and old age [20]. The impact of hope on depression and psychosocial adjustment was studied in persons with traumatic spinal cord injuries, where higher hope was associated with less depression and greater overall psychosocial adjustment, even after controlling for the time post-injury [21]. In another study, it was found that hope was negatively correlated with severity of depressive symptoms and that the relationship was moderated by mature defence styles [22]. Optimism is another concept that is referred to often when relating to a person’s way of coping. As does hope, it refers to the person’s future orientation, but more in tune with a general expectancy that good rather than bad will happen [23]. Thus, the optimist looks towards the future, attaching positive explanations even to negative outcomes. Indeed, optimists tend to use more problem-focused coping strategies than do pessimists. When problemfocused coping is not a possibility, optimists turn to more adaptive emotion-focused coping strategies such as acceptance and use of humour. Pessimists tend to cope through overt denial and by mentally and behaviourally disengaging from the goals with which the stressor is interfering [24]. Dispositional optimism was originally conceptualized as a unitary trait representing a single bipolar continuum, with optimism at one end of the spectrum and pessimism at the other [23]. Accordingly, Scheier and Carver’s [24] Life Orientation Test (LOT), one of the most popular measures for this trait, is typically considered to be a unidimensional measure of optimism [25]. However, other work suggests that dispositional optimism may consist of two separate sub-traits reflecting positively-framed optimism and negatively-framed pessimism. For example, Dember et al. [26] proposed a bidimensional model of optimism, in which people have both a level of optimism and a level of pessimism. Within this theoretical perspective, the rejection of pessimism is not the same as the endorsement of optimism. Empirical research supports this two-factor model, although there remains a disagreement as to how inter-correlated optimism and pessimism are [27]. Optimism plays an important role in the adjustment to stressful life events. Greater optimism was associated with fewer mood disturbances in response to a variety of stressors. For example, participants who were hospitalized for acute myocardial infarction experienced greater satisfaction with the treatment regime in accordance with higher scores in dispositional optimism and low depression scores [28]. Optimism was also found to be an important moderator of the association between Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. 802 G. Peleg et al. hopelessness and suicidal ideation; the study which encompassed 284 college students showed that higher dispositional optimism was strongly correlated to lowered degrees of experienced depression and suicidal ideation [29]. At times, dispositional optimism and hope are used as interchangeable constructs in popular discourse as in scientific journals. In recent research [27] it was stated that although the two concepts have a good correlational relationship they are still adhering to different theoretical constructs. More specifically it is argued that hope, as depicted by Snyder, focuses directly on expectations about the personal attainment of specific goals, whereas optimism, as depicted by Carver and Scheier, focuses on expected quality of future outcomes in general. Their theoretical point of contact being that a lack of agency in pursuit of a goal gives rise to the likelihood of pessimism about reaching that goal; whereas an absence of pathways towards a goal but a continued commitment for it (i.e., agency) does not necessarily promote such pessimism [27]. The present study explored these theoretical correlations among hope-agency, hope-pathways and optimism in the TBI population. The prolonged process of grief and loss in this population makes it a suitable test-case for the differential roles of the coping constructs. In particular, this study examined whether persons high in one or both coping variables may show better resilience to post-injury depression; in addition, whether this resilience is effective for both mild and severe depression. If so, then hope and optimism may play a role in better coping and improved rehabilitation sequel following TBI. participants were approached by either their therapist or attending psychiatrist in order to obtain informed consent. Sixty-five participants gave informed consent and were recruited to the research. The group comprised of 72.3% males, with a mean age of 28.8 years (SD9.0, range ¼ 18–55) and a mean of 12.9 years of education (SD ¼ 1.8, range ¼ 8–18); 67.7% were single, 27.7% married and 4.6% divorced; 67.7% of this group was unemployed, 23.1% employed and 9.2% students. Injury severity was determined based on Glasgow Coma Scale (GCS) scores: 31% sustained a mild injury, 8% a moderate injury and 61% a severe injury (mean ¼ 8.7, SD ¼ 4.2, range ¼ 3–15). Participants were on average 2.9 years post-injury (SD ¼ 2.3, range ¼ 0.5–9.7). In terms of aetiology, 75.4% were victims of road accidents, 12.3% of war accidents and 12.3% of falls. Measures Beck Depression Inventory (BDI) [30]. The questionnaire includes 21 self-report items in which the participant is asked to circle the item which best describes how they had been feeling in the past week. Subjects rate the severity of each symptom on a 4-point scale ranging between 0–3. A total score (range 0–63) is obtained by summing individual items’ scores. The questionnaire has been found to have both good reliability ( ¼ 0.87) and validity in assessing depression following TBI [31]. The Hebrew version of the BDI has a good internal reliability as well ( ¼ 0.78) [32]. Internal reliability in the present group was also good (Cronbach’s ¼ 0.9). Methods Participants The participants were recruited from the National Institute for the Rehabilitation of Persons with Brain Injuries and the Loewenstein Hospital Rehabilitation Centre, two of the largest brain injury rehabilitation facilities in Israel. Possible candidates for the research were selected from all consecutive admissions to recruitment institutes over a period of 18 months, based on examination of medical files for inclusion and exclusion criteria: medically documented TBI that occurred at least 6 months prior to the study; between the ages of 18–60 years old; able to give consent for participation; cognitively apt to answer the different questionnaires (as assessed by their therapist); non-psychotic; no reports of depression prior to TBI onset (pre-morbid depression was determined by the examiner, using the detailed anamneses in participants’ medical files). Following initial file examination, 82 potential Adult Hope Scale (AHS) [33]. The questionnaire includes 12 self-report items in which the participant is asked to circle the degree of agreement he has with the statement given on a 4-point scale (1–4). A total score is obtained by summing the items’ scores and reducing the scores of fillers (items number 3, 5, 7 and 11). The total hope score ranges from 8–32, with larger scores indicating higher levels of hope. The agency score is comprised of items 2, 9, 10 and 12 and the pathways score of items 1, 4, 6 and 8; in each the total score ranges from 4–16. A total score of 25.64 (SD ¼ 2.93) is the mean hope score in the healthy population. The mean agency score is 12.83 (SD ¼ 1.69) and the mean pathways score is 12.81 (SD ¼ 1.75) [32]. The AHS was translated to Hebrew and showed high internal consistency ( ¼ 0.8) [34]. Internal reliability in the present group was also good (Cronbach’s ¼ 0.8). Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. Hope, optimism and depression in TBI Life Orientation Test Revised (LOT-R) [24]. This instrument measures dispositional optimism. The questionnaire includes 10 self-report items in which the participant is asked to circle his or her degree of agreement with the statement given on a 5-point scale (0–4). A total score is obtained by summing the items’ scores, after reversing negative items (items number 3, 7 and 9) and reduction of four filler items (items number 2, 5, 6 and 8). The sum score ranges from 0–24, with larger scores indicating higher levels of optimism. A score of 14.33 (SD ¼ 4.28) is the mean score in the healthy population [24]. The LOT-R was translated to Hebrew [35] and showed a fair internal consistency ( ¼ 0.62). Internal reliability in the present group was similar (Cronbach’s ¼ 0.7). Participants’ demographic and injury related data questionnaire. This questionnaire included information regarding age, years of formal education, vocation and marital status. In addition, relevant injury-related data, including GCS score, aetiology of injury and time since occurrence of injury, was collected from the medical records. Procedure Participants were administered the questionnaires individually, in the order presented in the measures section. Participants who encountered difficulties in comprehending or filling the questionnaires were assisted by the examiner (assistance consisted solely of reading the questions aloud to the participant). The administration time was 20 minutes and was carried out at the rehabilitation centres the participants were attending at the time. Results Descriptive statistics Table I illustrates descriptive statistics of the participants’ scores in the three questionnaires. Table I. Participants’ depression levels, rates of hope and dispositional optimism in comparison to healthy adults (n ¼ 65). Study sample Mean (SD) BDI AHS AHS agency AHS pathways LOT-R 19.32 (11.7) 23.1 (5.0) 11.3 (2.9) 11.9 (2.7) 12.6 (5.2) Healthy adults Mean (SD) 6.18 25.64 12.83 12.81 14.33 (6.82) (2.93) (1.69) (1.75) (4.28) BDI ¼ Beck Depression Inventory; AHS ¼ Adult Hope Scale; LOT-R ¼ Life Orientation Test Revised. Healthy adults-see text for references. 803 The Kolmogorov-Smirnov tests of normality indicated that the BDI, the AHS and the LOT-R had normal distributions (d(65) ¼ 0.9, 1.2 and 0.7, respectively, p > 0.05). Therefore, all further analyses were performed using parametric tests. The BDI mean score indicates an overall moderate–evere level of depression [30]. Distribution of depression severity shows that 17 participants (26.2%) had a non-clinical depression level, 19 participants (29.2%) had a mild depression level, 15 (23.1%) had a moderate depression level and 14 (21.5%) a severe depression level. Using a one sample t-test, the obtained mean score was significantly higher (t(64) ¼ 9.1, p ¼ 0.000) than mean BDI scores of healthy adults [36]. The AHS mean score reflects medium–low levels of hope in the study group. In a one sample t-test, the obtained mean score was significantly lower (t(64) ¼ 4.0, p ¼ 0.000) in comparison to the general population norms [33]. The AHS agency and pathways mean scores were also significantly lower (t(64) ¼ 4.3, p ¼ 0.000; t(64) ¼ 2.8, p ¼ 0.006, respectively) in comparison to a sample of the general population. The LOT-R mean score was found to be in the lower regions of the possible range, reflecting low levels of optimism in the study group. In a one sample t-test, the obtained mean score was significantly lower (t(64) ¼ 2.7, p ¼ 0.009) in comparison to the general population norms [24]. Correlation analysis of depression, hope and dispositional optimism In order to examine the relations between depression and the coping variables in the study population, Pearson correlations were calculated between depression, hope and dispositional optimism scores. Results revealed significant negative yet moderate correlations between AHS and BDI scores (r ¼ 0.59, p ¼ 0.000), as well as between LOT-R and BDI scores (r ¼ 0.53, p ¼ 0.000). The AHS agency and pathways sub-scores also showed significant negative yet moderate correlations with the BDI (r ¼ 0.49, p ¼ 0.000 and r ¼ 0.57, p ¼ 0.000, respectively). Regarding the two coping variables, AHS and LOT-R scores correlated significantly in a moderate level (r ¼ 0.56, p ¼ 0.000) and the same pattern was evident between the LOT-R and the AHS agency and pathways subscores (r ¼ 0.44, p ¼ 0.000 and r ¼ 0.57, p ¼ 0.000, respectively). Depression severity and its correlations with hope and dispositional optimism In order to examine whether the correlation pattern found between depression and the coping variables Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. 804 G. Peleg et al. is the same across depression severity levels, the participants were divided to two groups, based on the original depression severity criteria defined by Beck et al. [30]: minimal–mild depression (0 < BDI score < 18); moderate–severe depression (19 < BDI score < 63). The minimal–mild group included 36 participants and the moderate–severe group 29 participants. In terms of demographic and injury-related variables, the moderate–severe group included significantly older participants (F(1, 64) ¼ 5.4, p < 0.05), a higher frequency of women (37.9 vs 19.4) and married people (34.5 vs 22.2). There were no statistically significant differences between the groups in severity of GCS, time since injury, years of education and employment status. Pearson correlations between depression and the coping variables were examined for each depression severity level, as outlined in Table II. The moderate–severe group’s correlations presented a similar pattern to the overall effect shown in the whole group, i.e. the BDI score showed significant negative correlations with the AHS and the LOT-R total scores. In addition, the BDI score showed significant negative correlations with the AHS agency and pathways sub-scores. However, in the case of the minimal–mild depression group, the correlation pattern was different. The BDI score showed a significant negative correlation with the AHS total score, but not with the LOT-R total score. This pattern is due to the correlation between BDI score and the AHS pathways sub-score, but not with the AHS agency sub-scale score. Prediction of depression severity—a regression analysis In order to examine the relative contribution of the coping, demographic and injury-related variables of the sample, a stepwise regression analysis was conducted. The BDI score served as the dependent variable and the AHS total score, the LOT-R total score, time since injury, injury severity (GCS score), employment status and age as predicting variables. Employment status is a categorical predictor and it was re-coded into two categories (participants in the ‘employed’, ‘volunteer’ or ‘student’ categories were re-assigned into one category, ‘occupied’, while unemployed participants were kept in a separate category). As can be seen in Table III, the model summary included the AHS and LOT-R scores [F(2, 62) ¼ 21.23, p ¼ 0.000] and accounted for 40.6% of the shared variance. However, it was the AHS score that contributed the majority of explained variance. The remaining variables, time since injury, injury severity, employment status and age, were excluded from the model. Discussion The present study investigated the potential role of positive coping constructs in depression following TBI. In replication of previous studies, it was found that high levels of depression were experienced in the study sample [3, 37]. Around 45% of the participants reported depressive symptoms in clinically significant levels, ranging from moderate-tosevere. A substantial number of studies show high rates of depression in the TBI population. These were found regardless of the specific tool used to evaluate depression levels, including the DSM Symptom Checklist [5], the SCL-90-R [4] and the BDI-II [38]. The depression scores of this study, as well as of the aforementioned TBI samples, are much higher than those reported in studies of healthy adults [36]. With respect to these high depression rates and the relative lack of known mediating factors, the present research explored the potential role of positive personality assets on postTBI depression. The degree of hope, as measured by the Adult Hope Scale, was found to be significantly lower in this sample as compared to norms reported in the Table II. Pearson correlation coefficients between depression, hope and dispositional optimism, following division to two depression severity sub-groups. AHS AHS pathways AHS agency LOT-R Minimal-to-mild depression levels (BDI ¼ 0–18), n ¼ 36 BDI 0.35* p < 0.05 0.43* p ¼ 0.01 AHS 0.86* p ¼ 0.000 AHS pathways AHS agency 0.19 0.88* 0.51* p > 0.1 p ¼ 0.000 p < 0.005 0.19 0.57* 0.60* 0.40* Moderate-to-severe depression levels (BDI ¼ 19–64), n ¼ 29 BDI 0.62* p ¼ 0.000 0.62* p ¼ 0.000 AHS 0.88* p ¼ 0.000 AHS pathways AHS agency 0.50* 0.91* 0.59* p < 0.01 p ¼ 0.000 p < 0.001 0.43* p < 0.05 0.334 p > 0.05 0.36 p > 0.05 0.25 p > 0.1 p > 0.1 p ¼ 0.000 p ¼ 0.000 p < 0.05 *Statistically significant correlations. BDI ¼ Beck Depression Inventory; AHS ¼ Adult Hope Scale; LOT-R ¼ Life Orientation Test Revised. Hope, optimism and depression in TBI Table III. Stepwise regression-the contribution of coping, demographic and injury severity variables in predicting depression severity (BDI). Step 1 Constant AHS Step 2 Constant AHS LOT-R B se B R2 50.86 1.36 5.59 0.24 0.59* 0.35 50.42 0.98 0.67 5.37 0.27 0.27 0.42* 0.30** 0.41 Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. AHS ¼ Adult Hope Scale; LOT-R ¼ Life Orientation Test Revised. *p < 0.005; **p < 0.05. general population [33, 39]. In fact, these results are low even in comparison to other health-challenged populations, such as women diagnosed with cancer [19] and traumatic spinal cord injury [21]. Dispositional optimism levels, as measured by the Life Orientation Test-Revised, were also low when compared to norms in the general population [24], as well as to health-challenged populations, including sickle-cell disease [40] and head and neck cancer [41]. As low levels of hope [14] and optimism [41] are known predictors of poor psychosocial outcomes and health quality-of-life, these findings provide further evidence to the claim prevalent in the TBI literature, that the effects of head trauma are often associated with poor long-term psychosocial outcomes, which decrease the individuals’ qualityof-life [42]. The correlation patterns between hope, dispositional optimism and depression indicate that both coping measures negatively correlated with participants’ depression levels. These findings accord with studies performed in the general population for hope [43]. Similarly, dispositional optimism and depression levels correlated negatively in students [44], as well as in middle-aged participants [45]. It seems that, despite the fact the individuals with TBI express high rates of depression and low coping abilities, still the correlation patterns are similar to those in non-injured samples and other healthchallenged populations. This may serve as an indication that similar affective processes are at work, thus supporting the claim that therapeutic methods employed with traumas and life changes in people without brain damage can be applicable for individuals who sustained TBI as well [46]. The correlations between depression and the coping variables also indicate that hope and optimism are not merely the phenomenological reversal of depression. Snyder et al. [33] showed that even when controlling for ‘negative affectivity’ (highly associated with depression), the hope score still preserved discriminant predictive power with regard 805 to problem-focused coping. With regard to optimism, in a longitudinal study, young adults with a ‘pessimistic cognitive style’ were more likely to develop clinical depression and clinical anxiety, thus showing optimism’s predictive potency in regard to these psychopathologies [47]. The two coping constructs showed a positive moderate correlation with each other. A similar pattern was described in two large samples of undergraduate students [27, 33]. There the correlation patterns were used to examine whether hope and optimism should be conceived as two separate constructs or as reflections of the same global underlying trait. Supporting a unitary conceptualization, hope and optimism share a sizeable portion of their variance and a single global factor provides a reasonable and parsimonious goodness-of-fit to the data. Indeed, both constructs share many things in common. Fundamentally, both stem from an expectancy-value approach to motivation and both were designed to assess individual differences in what are thought to be stable characteristics reflecting general expectations about the future [48]. On the other hand, Bryant and Cvengros [27] support a distinct construct approach to hope and optimism, claiming that separate hope and optimism factors had greater explanatory power than did a single global ‘super’ factor and that the two constructs showed divergent patterns of association with coping and self-efficacy. Their findings accord with the claim that, in comparison to optimism, the hope scales have provided unique and augmenting variance in predicting outcome [48]. The correlation pattern in the present study suggests that hope and optimism may contribute distinctively to a person’s coping following a major life trauma. This despite the fact that the coping strategies employed by TBI clients prior to their injury may no longer be available to them. Next was analysed the relationship between depression severity and the coping variables. In the case of participants who exhibited mild depression, hope-pathways was the factor which contributed to the negative correlation between hope and depression. Hope-pathways is assumed to reflect a direct, goal-oriented way of coping with challenges, as it refers to an individual’s perceived ability to find one or more effective ways to reach his or her goals, as well as the perceived ability to formulate alternative plans when obstacles get in the way of goal attainment [14]. These findings may indicate that, in the case of mild depression following TBI, the focus of concern is the difficulty of envisioning ways of coping with the trauma, rather than a loss in the internal locus of control. One possible clinical implication is to refer persons following TBI who manifest mild depression to therapies directed Brain Inj Downloaded from informahealthcare.com by Hebrew University on 03/29/11 For personal use only. 806 G. Peleg et al. towards enhancing explicit problem-solving strategies. In the case of moderate-to-severe depression, it was found that personality variables (hopeagency and optimism) now play a significant role, in addition to the goal-oriented coping which was observed in mild depression. This is in accordance with previous findings which indicated that hopeagency is a good predictor of severe psychopathology. For example, in a study that examined the correlations between the agency and pathways subscales and the clinical scales of the Minnesota Multiphasic Personality Inventory–II, it was found that the agency sub-scale was a stronger predictor of psychological maladjustment than the pathways sub-scale score [17]. In another study, the agency sub-scale was found to be the strongest predictor of suicidal ideation in college students [18]. The regression analysis indicates that the two coping variables, but not the demographic and injury-related variables, predicted depression severity in the current sample. The lack of impact of the latter variables on prediction of mood disorders is in accordance with the TBI literature, where persons with depression are no different from non-depressed individuals with respect to age, sex, race, socioeconomic status, marital status, educational level, type or severity of brain injury, family history of psychiatric disorder or the degree of physical or cognitive impairment [1, 3, 37]. Of more interest is the finding that of the two coping variables, hope is the more dominant in predicting depression severity. Although both hope and optimism are associated with positive expectations, those associated with hope are specifically oriented on the perceived ability to sustain action towards goal attainment. Optimism, on the other hand, is a more general expectation of positive events, is not specifically centred on the individual as the initiator of such events and is not focused on particular actions that may bring about those positive events [14]. The latter can prove to be a challenging task for individuals with TBI, dealing with everyday and chronic difficulties. The relationship between hope and depression was examined in greater detail by Chang and DeSimone [49]. They found that hope had both direct and indirect effects on severity of depressive symptoms, as measured by the BDI. The indirect effects were mediated via hope’s effect on coping style and secondary appraisals of control and effectiveness. However, hope still had a significant direct relationship with depression after the indirect effects were ruled out. This finding may account for another conception of hope’s dominance in accounting for depressive symptoms in TBI, through its relation to locus of control. It was shown that in cases of a dominant external locus of control, depression is more prevalent in participants post-stroke [50]. Persons with HIV, who attributed the quality of their health status to externally controlled variables (e.g. fate), also showed higher levels of depression [51]. Higher hope levels may represent a more internal dominant locus of control, the perception that one has the ability and the ways to control his or her own goal attainment. In conclusion, the present results replicate various findings in the TBI literature concerning the rate and severity of depression post-injury. In addition, it was shown that the levels of two coping variables, hope and dispositional optimism, were low in comparison to healthy adults. It seems that, in the TBI population, people characterized by worse coping skills are prone to exhibit higher levels of depression following the injury. However, this hypothesis should be further supported in future studies, via exploration of personal history or with functional variables such as vocational and educational success. Clearly, the fact that all of the participants were active participants in a rehabilitation programme hampers the ability to generalize from the current findings. The sample is comprised of persons during therapy and rehabilitation on average 2.9 years postinjury and thus may represent a biased sample of the TBI population. One may suspect that these participants are already in the process of therapeutic hope-induction or being treated for their depression. In the future, the authors expect to try and replicate these findings in a sample of persons with TBI who are not in the course of rehabilitation. Acknowledgements This research was facilitated by a grant from the Tel-Aviv Jaffa academic college and support from the research and development funding of the national institute for the rehabilitation of persons with brain injuries in Israel. Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper. References 1. Gordon WA, Zafonte R, Cicerone K, Cantor J, Brown M, Lombard L, Goldsmith R, Chandna T. Traumatic brain injury rehabilitation: State of the science. American Journal of Physical Medicine Rehabilitation 2006;85:343–382. 2. Mooney G, Speed J. The association between mild traumatic brain injury and psychiatric conditions. Brain Injury 2001;15: 865–877. 3. Jorge RE, Robinson RG, Moser D, Tateno A, CrespoFacorro B, Arndt S. Major depression following traumatic brain injury. Archives of General Psychiatry 2004;61:42–50. 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