DIVISION OF GASTROENTEROLOGY NIDDK CENTER FOR MOLECULAR STUDIES IN DIGESTIVE & LIVER DISEASES RESEARCH SEMINAR SERIES January—June 2012 1/5 JANUARY 2012 1/12 1/19 1/26 FEBRUARY 2012 2/2 2/9 2/16 2/23 MARCH 2012 3/1 3/8 3/15 3/22 29 4/5 APRIL 2012 4/12 4/19 4/26 5/3 MAY 2012 5/10 5/17 5/24 5/31 6/7 JUNE 2012 6/13 6/21 6/28 Lawrence B. Holzman, MD, Professor & Chief of Renal Division, UPENN, “From the Podocyte Intercellular Junction to Regulation of its Cytoskeleton” Nabeel M. Bardeesy, PhD, Assistant Professor of Medicine, MA General Hospital, Harvard Med. School, “Transcriptional Programs in Pancreatic Cancer” Douglas J. Epstein, PhD, Associate Professor of Genetics, UPENN, “Long Range Regulation of Sonic Hedgehog Expression in Brain Development and Disease” Ling Qin, PhD, Assistant Professor of Orthopedic Surgery, UPENN, “EGFR, A Novel Mediator of the Anabolic Frédéric Lemaigre, MD, PhD, Professor of Microbiology; Université Catholique de Louvain; Transcription Factor-microRNA Networks in Liver and Pancreatic Cell Differentiation” ; Kaufman Lecture Todd Ridkey, MD, Assistant Professor of Dermatology; UPENN; “Engineering Three-dimensional Invasive Human Cancers in Vitro” Ken Zaret, PhD, Joseph Leidy Professor of Cell & Developmental Biology; UPENN; “Induced Pluripotent Stem Cells from Human Pancreatic Cancer that Recapitulate Early Stages of the Disease” TBA TBA Michael Ostap, PhD, Director Penn Muscle Institute; UPENN; “Motors Moving Membranes—From Molecules to Cells” Joseph Kissil, PhD, Associate Professor; Molecular & Cellular Oncogenesis Program; Wistar Institute; “"The Opposing Roles of Notch in Cancer" ” E. John Wherry, PhD, Associate Professor of Microbiology; UPENN; “Regulation of T Cell Responses to Persisting Infections” Erica Golemis, PhD, Adjunct Associate Professor of Cell & Development; UPENN; “NEDD 9 in Tumor Initiation, Progression and Metastasis” Ellen Pure, PhD, Professor, Molecular & Oncogenesis Program; Wistar Institute; “Defining Stromal Cells and their Function in the Tumor Microenvironment” Susan J. Baserga, MD, PhD, Professor of Molecular Biophysics & Biochemistry, of Genetics and of Therapeutic Radiology; Yale University; “New Insights Into How We Make Ribosomes” Maureen Murphy, PhD, Professor and co-Leader Molecular & Cellular Oncogenesis Program; Wistar Institute; “Coding Region Polymorphisms in p53 that Regulate Inflammation, Apoptosis & Metabolism” Susan Janicki, PhD, Assistant Professor; Wistar Institute; “Mechanistic Insights into Gene Regulation using Single-Cell Imaging” Jonathan Brody, PhD, Director Surgical Research; Thomas Jefferson University; “Proto-Oncogene 2.0: HuR Regulates Multiple-core Signaling Pathways in Pancreatic Ductal Adenocarcinoma” Jean-Pierre Issa, MD, Professor of Medicine; Director of Fels Institute for Cancer & Molecular Biology; “Genetic and Epigenetic Interactions in Colon Cancer.” DDW Meeting DDW Meeting Eric Fearon, MD, PhD, Chief, Molecular Medicine & Genetics; Professor Oncology; Internal Medicine; Human Catherine Lee May, PhD; Assistant Professor of Pathology & Laboratory Medicine; CHOP; “Endocrine Cell Development in the Digestive System” Center Symposium and Retreat, Constitution Center Kathryn Wellen, PhD, Assistant Professor, Department of Cancer Biology; UPENN / Abramson; “Nutrientsensing through Acetylation ” George Cotsarelis, MD; Chairman, Milton B. Hartzell Professor; UPENN; “TBD” MeeƟngs are held in CRB 702 and begin promptly at 12 NOON each Thursday, unless noted. Refreshments will be served.