Curriculum Vitae
Lars Erik Olson, Ph.D.
Current Address
(Business)
Marquette University
Department of Biomedical Engineering
P.O. Box 1881
Milwaukee, WI 53201-1881
(Home)
4305 North Farwell Avenue
Shorewood, WI 53211
Date and Place of Birth:
September 18, 1965, Nashville, TN
Marital Status:
Married, Three Children
Fields of Specialization:
Mathmatical Modeling
Biomedical Instrumentation and Optics
Cell Engineering/Cardiopulmonary Physiology
Computing
Biological Fluid and
Mass Transport
Education:
Ph.D.
1993
Biomedical Engineering, Vanderbilt University, Nashville, TN
Dissertation title: An Optical Multiple Indicator Dilution Method for
Measuring Lung Microvascular Permeability-Surface Area
M.S.
1989
Biomedical Engineering, Vanderbilt University, Nashville, TN
Thesis title: The Assessment of Lung Microvascular Permeability by Multiple
Indicator Dilution: the Use of 14C-1,4-Butanediol and 14C-Urea as BarrierLimited Tracers
B.S.E.
1987
Electrical Engineering, Tulane University, New Orleans, LA
Honors:
Marquette University College of Engineering Outstanding Teacher Year Award, 1996, 2003.
Proctor and Gamble American Physiological Society Graduate Student Award, 1991.
Vanderbilt University Graduate Student Research Day Award (Science), 1989.
Harold Stirling Vanderbilt Scholar.
Professional Experience:
2000 to Present
Associate Professor, Department of Biomedical Engineering, Marquette
University, Milwaukee, WI.
1993 to 2000
Assistant Professor, Department of Biomedical Engineering, Marquette
University, Milwaukee, WI.
1988 to 1993
Pre-doctoral Fellow, Department of Biomedical Engineering, Graduate
School, Vanderbilt University, Nashville, TN.
1987 to 1988
Graduate Research Assistant, Department of Electrical and Biomedical
Engineering, School of Engineering, Vanderbilt University, Nashville, TN.
1987
Graduate Teaching Assistant, Department of Electrical and Biomedical
Engineering, School of Engineering, Vanderbilt University, Nashville, TN
Professional Societies:
Biomedical Engineering Society.
American Physiological Society.
Sigma Xi.
Scholarly Works:
Refereed Journal Publications
Olson, L.E., A. Pou, and T.R. Harris. Surface-area independent assessment of lung microvascular
permeability using an amphipathic tracer. J. Appl. Physiol. 70:1085-1096, 1991.
Olson, L.E., D.J. Staton, M. Young, R.L. Galloway, and T.R. Harris. Sulfhemoglobinated
erythrocytes as an optical intravascular tracer in the lung. Annals of Biomed. Eng. 22:319-327, 1994.
Olson, L.E., T.R. Harris, A. Pou, M.N. Sayed-Ahmed, and R.L. Galloway., An optical multiple
indicator dilution technique to measure lung permeability-surface area: calibration and baseline
measurement. IEEE Trans. Biomed. Eng. 42:451-463, 1995.
Feiring, A.J., and L.E. Olson. Coronary stent and over-the-wire catheter exchange using standard
length guide wires; jet exchange "JEX" practice and theory. Catheterization and Cardiovascular
Diagnosis, 42:457-466, 1997.
Olson, L.E., M.P. Merker, R.D. Bongard, B.M. Brantmeier, S.H. Audi, J.H. Linehan, and C.A.
Dawson. Kinetics of plasma membrane electron transport in a pulmonary endothelial cell-column.
Annals of Biomed. Eng. 26:117-127, 1998.
Merker, M.P., L.E. Olson, R.D. Bongard, M.K. Patel, J.H. Linehan, and C.A. Dawson.
Ascorbate - mediated transplasma membrane electron transport in pulmonary arterial endothelial
cells. Am. J. Physiol. (Lung Cell Mol. Physiol.) 274:L685-L693, 1998.
DeMarino, S., L.E. Olson, N.A. Pou, S.U. Adams, and T.R. Harris. Optical and radioisotope
indicator dilution measurements in pulmonary edema. Annals of Biomed. Eng. 26: 417-430, 1998.
Olson, L.E., Merker, M.P., Patel, M.K., Bongard, R.D., Daum, J.D., Johns, R.A., and C.A. Dawson.
Cyanide increases reduction but decreases sequestration of methylene blue by endothelial cells.
Annals of Biomed. Eng. 28(1):85-93, 2000.
Audi, S.H., Olson, L.E., Bongard, R.D., Roerig, D.L., Schulte, M.L., and C.A. Dawson.
Toluidine blue O and methylene blue as endothelial redox probes in the intact lung. Am. J. Physiol.
(Heart Circ. Physiol) 278(1):H137-H150, 2000.
Dawson, C.A., Audi, S.H., Bongard, R.D., Okamato, Y., Olson, L.E., and M.P. Merker. Transport
and reaction at endothelial plasmalemma: Distinguishing intra- from extracellular events. Annals of
Biomed. Eng. 28:1010-1018, 2000.
Effros RM. Hogan G. Wahlen Hoagland K. Olson L. and W. Lin. Protection of the lungs from acid
during aspiration. American Journal of Medicine. 111 Suppl 8A:56S-59S, 2001.
LaDisa, J.F., Hettrick, D.A., Olson, L.E., Guler, I., Gross, E.R., Kress, T.T., Kersten, J.R., Warltier,
D.C., and P.S. Pagel. Stent implantation alters coronary artery hemodynamics and wall shear stress
during maximal vasodilation. J. Appl. Physiol. 93(6):1939-46, 2002.
Gross, E.R., LaDisa, J.F., Weihrauch D, Olson, L.E., Kress, T.T. Hettrick, D.A., Pagel, P.S. Warltier,
D.C. and J.R. Kersten. Reactive oxygen species modulate coronary wall shear stress and endothelial
function during hyperglycemia. Am. J. Physiol. (Heart Circ. Physiol.) 284(5):H1552-9, 2003.
LaDisa, J.F., Guler, I, Olson, L.E., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and P.S. Pagel.
Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear
stress produced by stent implantation. Ann. Biomed. Eng. 31(8):972-80, 2003.
R.M. Effros, Olson, L.E., Lin, W., Audi, S.H., Hogan, R., Shaker, R., Hoagland, K., and B. Foss.
Resistance of the pulmonary epithelium to movement of buffer ions. Am J. Physiol. (Lung Cell Mol.
Physiol.) 285:L476-83, 2003.
Savla, U., Olson, L.E. and C.M. Waters. Mathematical modeling of airway epithelial wound closure
during cyclic mechanical strain. J. Appl. Physiol. 96(2):566-74, 2004.
LaDisa, J.F., Olson, L.E., Guler, I., Hettrick, D.A., Audi, S.H., Kersten, J.R., Warltier, D.C., and P.S.
Pagel. Stent design properties and deployment ratio influences indexes of wall shear stress: a threedimensional computational fluid dynamics investigation with a normal artery. J. Appl. Physiol.
97(1): 424-30, 2004.
LaDisa, J.F.*, Olson, L.E., Guler, I., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and P.S. Pagel.
Circumferential stress evaluated using time-dependent 3D computational fluid dynamics models.
J. Appl. Physiol. 97(1):424-430, 2004.
Ladisa, J.F., Olson, L.E., Guler, I., Hettrick, D.A., Kersten, J.R., Warltier, D.C., Pagel, P.S.
Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with
time-dependent 3D computational fluid dynamics models. J. Appl. Physiol. 98(3): 947-57, 2005.
Ladisa, J.F. Olson, L.E., Molthen, R.C., Hettrick, D.A., Pratt, P.F. Hardel, M.D., Kersten, J.R.,
Warltier, D.C., Pagel, P.S. Alterations in wall shear stress predict sites of neointimal hyperplasia
after stent implantation in rabbit iliac arteries. Am. J. Physiol. Heart Circ. Physiol. 288(5):H2465-75,
2005.
Ladisa, J.F., Olson, L.E., Ropella, K.M., Molthen, R.C., Haworth S.T., Kersten, J.R., Warltier, D.C.,
Pagel, P.S. Microfocal X-Ray computed tomography post-processing operations for optimizing
reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling.
Comput. Methods Programs Biomed. 79(2):121-134, 2005.
LaDisa JF Jr.* Olson LE. Hettrick DA. Warltier DC. Kersten JR. Pagel PS.
Axial stent strut angle influences
wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of
stent foreshortening. Biomedical Engineering Online. 4:59, 2005.
LaDisa JF Jr.* Olson LE. Douglas HA. Warltier DC. Kersten JR. Pagel PS.
Alterations in regional vascular
geometry produced by theoretical stent implantation influence distributions of wall shear stress:
analysis of a curved coronary artery using 3D computational fluid dynamics modeling. Biomedical
Engineering Online. 5:40, 2006.
Book Chapter
Dawson, C.A., R.D. Bongard, D.L. Roerig, M.P. Merker, Y. Okamoto, S.H. Audi, L.E. Olson, G.S.
Krenz, and J. H. Linehan. Pulmonary Endothelial Surface Reductase Kinetics. Whole Organ
Approaches to Cellular Metabolism, Permeation, Cellular Uptake, and Product Formation.
J.B. Bassingthwaighte, C.A. Goresky and J. H. Linehan, Eds. New York, Springer-Verlag, 1998.
Invited Paper
Olson, L.E., R.D. Bongard, M.P. Merker, J.H. Linehan, and C.A. Dawson. Endothelial transplasma
electron transport. Annals of Biomed. Eng. 25:S-19, 1997.
Refereed Conference Proceedings
Olson, L.E., Galloway, R.L., Harris, T.R. Real-time assessment of lung microvascular permeability:
Use of a CO2 laser aids measurement of 1,2-propanediol concentration. Proc. IEEE/EMBS
13(1):281-2, 1991.
Olson, L.E., and Goldberg, J.R., International Service Learning Senior Design Projects: Human
Power and Medical Devices., Proceedings of FIE, F4B, 2007.
Conference Sessions Organized and Presented
Olson L.E. Session on International Service Learning, BMES annual meeting, 2006. Presented
“Service learning solutions for appropriate respiratory technology in Central America.”
Olson, L.E., Glucksberg, M.R., Malkin, R.A., and Poluta, M. Special Session-Biomedical
Engineering Ethics and Standards in the Developing World. FIE Conference, 2007.
Conference Presentations
Harris, T.R., Olson, L.E., Pou, A. Lipid Solubility increases the sensitivity of indicators for
endothelial damage in the lung. Proceedings of the World Congress on Medical Physics and
Biomedical Engineering 33(1):351, San Antonio, TX, 1988.
Olson, L.E., Pou, A., Harris, T.R. Measurements of amphipathic and hydrophilic indicator-dilution
tracers in the lung provide a surface area independent assessment of permeability changes. FASEB J.
3:A1140, New Orleans, LA, 1989.
Olson, L.E., Pou, A., Harris, T.R. Evidence for the validity of 14C-1,4-butanediol (B) as a barrierlimited, multiple indicator dilution (MID) tracer in the lung. FASEB J. 4:A1181, Washington, DC,
1990.
Olson, L.E., Galloway, R.L., Pou, A., Harris, T.R. Optical measurements in whole blood of tracers
for lung microvascular permeability. FASEB J. 5:A754, Atlanta, GA, 1991.
Olson, L.E., Pou, A., Syed - Ahmed, M.N., Galloway, R.L., Harris, T.R. On-line, optical
measurement of lung permeability surface area (PS) is sensitive to hypoxia and alloxan injury.
FASEB J. 7(3):A2924, New Orleans, LA, 1993.
Olson, L.E., R.D.Bongard, C.A. Dawson, and J.H. Linehan. On-Line detection of reduction and
sequestration of thiazine dyes by the lung. FASEB J. 8:A916, Anaheim, CA, 1994
Krenz, G.S., C.A. Dawson, J.H. Linehan, R.D. Bongard, M.P. Merker, and L.E. Olson. A simple
model of methylene blue reduction in the lung. Annals of Biomed. Eng. 22:44, Tempe, AZ, 1994.
Olson, L.E., M.P. Merker, R.D. Bongard, J.H. Linehan, and C.A. Dawson. Effect of hypoxia and
potassium ferricyanide on thiazine dye reduction and uptake in a cell-column model of the
pulmonary microvasculature. Annals of Biomed. Eng. 23:S-12, Boston, MA, 1995.
Olson, L.E., M.P. Merker, J.H. Linehan, and C.A. Dawson. Effect of flow on thiazine dye reduction
and uptake in a cell-column model of the pulmonary microvasculature. FASEB J. 10:A719, Atlanta,
GA, 1995.
Olson, L.E., R.D. Bongard, S.H. Audi, D.L. Roerig, J.H. Linehan, and C.A. Dawson. Plasma protein
binding and Toluidine Blue O (TBO) reduction in the pulmonary circulation. FASEB J. 11:A100,
University Park, PA, 1996.
Olson, L.E., R.D. Bongard, M.P. Merker, S.H. Audi, M.L. Schulte, J.H. Linehan and C.A. Dawson.
Comparison of transplasma membrane electron transport by pulmonary endothelial cells in situ and
in cell culture. Annals of Biomed. Eng. 24:S-27, University Park, PA, 1996.
Olson, L.E. and A.J. Feiring. Analysis of dynamics of a novel technique for over-the-wire balloon
catheter exchange during stent deployment. Annals of Biomed. Eng. 24:S-27, University Park, PA,
1996.
Dembowski, E.T., L.E. Olson, G.S. Krenz, S.H. Audi, C.A. Dawson, and J.H. Linehan. Effect of online sampling and dye properties on optical measurements in a flow-through endothelial cell system.
Annals of Biomed. Eng. 24:S-54, University Park, PA, 1996.
Olson, L.E., R.D. Bongard, M.P. Merker, M.K. Patel, J.H. Linehan, and C.A. Dawson. Endothelial
redox status and transplasma membrane electron transport. FASEB J. 11:A136, New Orleans, LA,
1997.
Bongard, R.D., L.E. Olson, M.K. Patel, J.H. Linehan, C.A. Dawson, and M.P. Merker.
Dehydroascorbate stimulates pulmonary arterial endothelial cell transplasma membrane electron
transport. FASEB J. 12:A182, San Francisco, CA, 1998.
Olson, L.E., R.D. Bongard, M.P. Merker, M.K. Patel, J.H. Linehan, and C.A. Dawson. Effect of
cyanide on kinetics of extracellular reduction and intracellular reoxidation of Methylene Blue (MB)
by endothelium. FASEB J. 12:A182, San Francisco, CA, 1998.
Olson, L.E., Merker, M.P., Bongard, R.D., Linehan, J.H., and C.A. Dawson. Cell column studies of
endothelial transplasma membrane electron transport (ETMET) mechanisms. Annals of Biomed.
Eng. 26(S):S-51, 1998.
Vosniak, K.J., Olson, L.E., Clough, A.V., Linehan, J.H., and C.A. Dawson. Computational fluid
dynamics model study of transit time through arterial trees. Annals of Biomed. Eng. 26(S):S-65,
1998.
Olson, L.E., Audi, S.H., Lin, N., Lin, W., and C.A. Dawson. Adaptation to hyperoxia results in
pulmonary sequestration of toluidine blue O (TBO+). FASEB J. 13:A184, 1999.
Clough, A.V., Haworth, S.T., Vosniak, K.J., Dawson, C.A., and L.E. Olson. Transit time through
the pulmonary arterial tree: Experimental and modeling observations. FASEB J. 13:A428, 1999.
Olson, L.E. Yakubovich, O., Clough, A.V., and C.A. Dawson. A fast algorithm for predicting transit
times through arterial trees. FASEB J. 14:A168, 2000.
Olson, L.E., Effros, R.M., Hogan, G., and W. Lin. Alveolar pH changes and trans-alveolar transport.
Annals of Biomed. Eng. 28(S):S-48, 2000.
Gross, E.R., Olson, L.E., Weihrauch, D., Kersten, J.R., Hettrick, D.A., Pagel, P.S., and D.C.
Warltier. Acute hyperglycemia alters shear and oxidant stress in coronary arteries in vivo. Annals of
Biomed. Eng. 28(S):S-63, 2000.
LaDisa, J.F., Olson, L.E., DiCaprio, F., Guler, I., and D.C. Warltier. In vivo measurement and fluid
dynamics modeling of hemodynamic changes produced by coronary stenting. FASEB J. 2001.
LaDisa, J.F., Olson, L.E., Hettrick, D.A., Guler, I., DiCaprio, F., Pagel, P.S., Kersten, J.R., and D.C.
Warltier. Computational fluid dynamics modeling of hemodynamic changes caused by coronary
stenting in vivo. Ann. Biomed. Eng., 2001.
LaDisa, J.F., Olson, L.E., Guler, I., Gross, E.R., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and
P.S. Pagel. Coronary stent implantation alters wall shear stress during maximal vasodilation. IEEE
Engineering in Medicine and Biology Proceedings v2 2002:1228-9, 2002.
Schedgick, D.J., Olson, L.E., Bigelow, L.K. and W.E. Brower. Cryopreservation of erythrocytes
without a cryoprotectant by rapid quenching and rewarming. Cryobiology, 2002.
LaDisa, J.F., Warltier, D.C., Olson, L.E., Kersten, J.R., and P.S. Pagel. Shear-modulated neointimal
hyperplasia after stent implantation. FASEB J. 2003.
Ladisa, J.F., Olson, L.E., Kersten, J.R., Warltier, D.C., and P.S. Pagel, Wall shear stress varies with
stent properties and correlates with sites of neointimal hyperplasia. Ann. Biomed. Eng., 2003.
Zitomer, D., Olson, L.E., Borg, J. International Service Learning at Marquette University. Role of
Engineering at Catholic Universities (RECU) Conference in Dayton, OH 2005.
Olson, L.E., LaDisa, J.F. A model of Shear-Dependent neointimal growth of stented vessels, Ann.
Biomed. Eng. 2007.
Olson, L.E. One-dimensional approximations do not predict pressure and flow in bifurcations with
parameterized geometries. Annals of Biomed. Eng. 36(S), 2008.
Graduate Student Interaction
Thesis Advisor:
Student
Involvement
Sejal Patel
M.S. Thesis Advisor
FA96 - FA98
Title: A Model of Pulmonary Endothelial Transplasma Membrane
Electron Transport: Inclusion of Plasma-Protein Binding.
Meha Patel
M.S. Thesis Advisor
FA96 – SP99
Title: The Effect of Cyanide on Methylene Blue Reduction and
Uptake in Cell Columns
Kenneth Vosniak
M.S. Thesis Advisor
SP98 – FA99
Title: Computational Fluid Dynamic Studies of Transit Time
Through Arterial Bifurcations
John Ladisa
M.S. Thesis Advisor
SP00-SU01
Title: Computational Fluid Dynamic Study of Coronary Arterial Stents
John LaDisa
Semesters
Ph.D. Dissertation Advisor
FA01-SP04
Title: Computational Fluid Dynamics Estimations of
Wall Shear Stress
Alterations Influencing Neointimal Hyperplasia After Stent Implantation.
Jason Clyne
M.S. Thesis Advisor
FA03-F05
Distensibility of Coronary and Intestine Arterioles in Relation to Heart
Disease.
Ankit Shah
M.S. Thesis Advisor
SP04-F05
Development of an In Vitro Vascular Flow Model to Determine the
Pharmacokinetics of Locally Delivered Therapeutics: A Comparison of Drug Physiochemical
Properties and Modes of Delivery.
Thesis Committees:
Student
Involvement
Semesters
Amir Al-Tinawi
Junghwa Hong
Mary Spilker
Todd Schmeling
Jason Daum
Ushma Savla
Ph.D. Committee Member
Ph.D. Committee Member
M.S. Committee Member
M.S. Committee Member
M.S. Committee Member
Northwestern University, Ph.D.
Committee Member
Ph.D. Committee Member
M.S. Committee Member
Ph.D. Committee Member
Ph.D. Committee Member
M.S. Committee Member
Fall 1993 – Fall 1994
Fall 1994 – Spring 1996
Fall 1995 – Fall 1998
Spring 1998 – Fall 1998
Spring 1998 – Fall 1998
David Schedgick
Michael Stineman
Moses Darpoalarr
Darryl Mazzari
Andrew Williams
Fall 2003-Spring 2004
Fall 2001 - Summer 2004
Fall 2004 -Fall 2005
2005-2006.
2007-Present.
2008.
Invited Lectures
Olson, L.E. Endothelial transplasma membrane electron transport: measurement and modeling.
National Simulation Resource on Mathematical Modeling Symposium, 1997.
Olson, L.E. "Optical Probes of Vascular Anti-Oxidant Mechanisms" Northwestern University
Biomedical Engineering Departmental Seminar, February 13, 1998.
Olson, L.E. "Bioreactor Studies and Vascular Anti-Oxidant Mechanisms" Pennsylvania State
University Biomedical Engineering Departmental Seminar, November 11, 1999.
Olson, L.E. “A better method for Cryopreserving Cells: Case Study of Erythrocytes” Medical
College of Wisconsin, September 26, 2002
Research Projects Funding
Principal Investigator - Marquette Research Challenge Grant: "Analysis of Functional Brain
Magnetic Resonance Images using Fiber - optic Cortical Measurements", for $10,000 in 1994/95.
Co–Investigator (J.H. Linehan P.I.) – National Institutes of Health, Heart Lung and Blood Institute:
“Lung Metabolism of Vasoactive Hormones”, for $132,062 per year from 1995 – 1999.
Role: Develop mathematical models and numerical solution methods for identification of parameters
of endothelial function. Develop new optical methods for investigation of lung metabolism.
Principal Investigator - Anthony J. and Rose E. Bagozzi Medical Research Fellowship: “Equipment
and Supplies for Endothelial Cell Investigation”, for $9,300 from 1996 – 1999.
Co–Investigator (. J.H. Linehan, P.I.) - Ralph and Marion Falk Medical Research Trust:
“Primary Pulmonary Hypertension”, for $360,000 from 1997 – 1998.
Role: Develop probes of endothelial function, which influence the pulmonary hypertension. Use
computation fluid mechanics to study mechanical aspects of pulmonary.
Functional Imaging Faculty-Whitaker Foundation Special Opportunity Award: “Ph.D. Degree
Program in Functional Imaging”, for $331,000 per year from 1996-1999.
Role:Consultant—Participate in functional imaging training.
Principal Investigator-American Heart Association Beginning Grant-in-Aid: “Endothelial
Transplasma Membrane Electron Transport: Mechanisms and Roles in Intracellular Signaling” for
$69,992 from 1999-2001.
Principal Investigator-Scimed Life Systems Graduate Industrial Fellowship: “In vivo Computational
Fluid Dyanamics Modeling of Coronary Stent Mechanics and Dynamics” for $39,910 from 20002002.
Investigator, NSF Grant, “Acquision of a Linux Cluster to Support College-wide Research and
Teaching Activities” 2006.
Other Scholarly Activities
Reviewer, Journal of Applied Physiology
Reviewer, Annals of Biomedical Engineering
Reviewer, Biochimica et Biophysica Acta\
Reviewer, Journal of Biomechanical Engineering.
Service Activities
College of Engineering Service
Biomedical Engineering Department Graduate Committee, 1993-1998
Mechanical Engineering Curriculum Committee, Fluid Mechanics Area, 1994-present
Instructor for the Marquette University Young Scholars Program, 1994.
College of Engineering Task Force on Computer Aided Design, 1995-present
Advisor for the Biomedical Engineering Society (BMES) Marquette University Graduate Student
Chapter, 1995-present
Engineering College Computer Resources Committee, 1995
Biomedical Engineering Department Undergraduate Committee, 1998-present
Chair, Biomedical Engineering Department Undergraduate Committee 2000-2004
Faculty Advisor, Student Chapter of BMES 2000-Present
Member, Health Environment and Infrastructure in Latin America.
Co-director, 2004 Spring International Service Learning Guatemala Trip.
Director, 2005 Spring International Service Learning Guatemala Trip.
Professional Service
1997, Served on National BMES Student Awards Committee
1996, Organizer/Chair of session of annual National BMES meeting.
2005 Organizer/Chair of session of annual National BMES meeting.
2006 Organizer/Chair of session of annual FIE meeting.