Contact:
Franco Mantero MD
Professor of Endocrinology and Medicine
Div. of Endocrinology, Department of Medical Sciences, University of Padua,
Via Ospedale 105, 35128 Padua, Italy
franco.mantero@unipd.it
Staff
Maria Verena Cicala(Clinical Research)
Beatrice Rubin & Raffaele Pezzani (Biologists)
Research interests
Clinical: Confirmatory tests for diagnosis of Primary Aldosteronism, Evaluation of AVS, Long term
cardiovascular effect of medical or surgical treatment of primary Aldosteronism.
Basic: Somatic mutations, aberrant receptors, Wnt/Beta cathenin pathway in APA.
Recent publications
Response to Effectiveness of adrenalectomy and aldosterone antagonists for long-term treatment of
primary aldosteronism.
Rossi GP, Cesari M, Cuspidi C, Maiolino G, Cicala MV, Bisogni V, Mantero F, Pessina AC.
Hypertension. 2013 Oct;62(4):e14.
Long-term control of arterial hypertension and regression of left ventricular hypertrophy with treatment
of primary aldosteronism.
Rossi GP, Cesari M, Cuspidi C, Maiolino G, Cicala MV, Bisogni V, Mantero F, Pessina AC.
Hypertension. 2013 Jul;62(1):62-9.
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary
hypertension.
Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR,
Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B,
Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R,
Vilsen B, Zennaro MC, Strom TM, Reincke M.
Nat Genet. 2013 Apr;45(4):440-4, 444e1-221.
Unilateral adrenal hyperplasia: a novel cause of surgically correctable primary hyperaldosteronism.
Iacobone M, Citton M, Viel G, Boetto R, Bonadio I, Tropea S, Mantero F, Rossi GP, Fassina A, Nitti D,
Favia G.
Surgery. 2012 Dec;152(6):1248-55
Select item 2301239223.
Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of
primary aldosteronism by adrenal vein sampling.
Seccia TM, Mantero F, Letizia C, Kuppusamy M, Caroccia B, Barisa M, Cicala MV, Miotto D, Rossi GP.
J Clin Endocrinol Metab. 2012 Dec;97(12
Prospective appraisal of the prevalence of primary aldosteronism in hypertensive patients presenting
with atrial flutter or fibrillation (PAPPHY Study): rationale and study design.
Rossi GP, Seccia TM, Gallina V, Muiesan ML, Leoni L, Pengo M, Ragazzo F, Caielli P, Belfiore A, Bernini G,
Cipollone F, Cottone S, Ferri C, Giacchetti G, Grassi G, Letizia C, Maccario M, Olivieri O, Palumbo G,
Rizzoni D, Rossi E, Sechi L, Volpe M, Mantero F, Morganti A, Pessina AC.
J Hum Hypertens. 2013 Mar;27(3):158-63
Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models.
Mariniello B, Rosato A, Zuccolotto G, Rubin B, Cicala MV, Finco I, Iacobone M, Frigo AC, Fassina A,
Pezzani R, Mantero F.
Endocr Relat Cancer. 2012 Jul 22;19(4):527-39.
Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical
cells.
Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV, Pezzani R, Auchus RJ, Ghayee
HK, Shibata H, Kurihara I, Williams TA, Giri JG, Bollag RJ, Edwards MA, Isales CM, Rainey WE.
J Clin Endocrinol Metab. 2012 Aug;97(8):E1567-72. doi: 10.1210/jc.2011-3132. Epub 2012 May 24.
36.
Primary aldosteronism: the role of confirmatory tests.
Salvà M, Cicala MV, Mantero F.
Horm Metab Res. 2012 Mar;44(3):177-80. doi: 10.1055/s-0032-1304661. Epub 2012 Mar 6. Review.
Related citations
Select item 2227552738.
Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.
Boulkroun S, Beuschlein F, Rossi GP, Golib-Dzib JF, Fischer E, Amar L, Mulatero P, Samson-Couterie B,
Hahner S, Quinkler M, Fallo F, Letizia C, Allolio B, Ceolotto G, Cicala MV, Lang K, Lefebvre H, Lenzini L,
Maniero C, Monticone S, Perrocheau M, Pilon C, Plouin PF, Rayes N, Seccia TM, Veglio F, Williams TA,
Zinnamosca L, Mantero F, Benecke A, Jeunemaitre X, Reincke M, Zennaro MC.
Hypertension. 2012 Mar;59(3):592-8. doi: 10.1161/HYPERTENSIONAHA.111.186478. Epub 2012 Jan 23.
A clinical phenotype mimicking essential hypertension in a newly discovered family with Liddle's
syndrome.
Rossi E, Farnetti E, Nicoli D, Sazzini M, Perazzoli F, Regolisti G, Grasselli C, Santi R, Negro A, Mazzeo V,
Mantero F, Luiselli D, Casali B.
Am J Hypertens. 2011 Aug;24(8):930-5. 48.
A case of primary aldosteronism in pregnancy: do LH and GNRH receptors have a potential role in
regulating aldosterone secretion?
Albiger NM, Sartorato P, Mariniello B, Iacobone M, Finco I, Fassina A, Mantero F.
Eur J Endocrinol. 2011 Mar;164(3):405-12
Primary aldosteronism: what consensus for the diagnosis.
Cicala MV, Mantero F.
Best Pract Res Clin Endocrinol Metab. 2010 Dec;24(6):915-21
The aldosterone-renin ratio based on the plasma renin activity and the direct renin assay for diagnosing
aldosterone-producing adenoma.
Rossi GP, Barisa M, Belfiore A, Desideri G, Ferri C, Letizia C, Maccario M, Morganti A, Palumbo G,
Patalano A, Roman E, Seccia TM, Pessina AC, Mantero F; PAPY study Investigators.
J Hypertens. 2010 Sep;28(9):1892-9
The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosteroneproducing adenomas.
Nogueira EF, Gerry D, Mantero F, Mariniello B, Rainey WE.
Clin Endocrinol (Oxf). 2010 Jul;73(1):22-9.
Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society
clinical practice guideline.
Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M, Young WF Jr, Montori
VM; Endocrine Society.
J Clin Endocrinol Metab. 2008 Sep;93(9):3266-81.