Monthly Healthcare Review March 2015 IPOs The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month. Company Name Last Financing Date HQ Location Cerenis Therapeutics (CEREN) 05-Mar-2015 Labege, France Redx Pharma (REDX) 26-Mar-2015 SteadyMed (STDY) 20-Mar-2015 Liverpool, United Kingdom San Ramon, CA Description Last Financing Size ($ millions) Lead Manager(s) Developer of high density lipoprotein (HDL) compounds for the treatment of cardiovascular and metabolic diseases. The company’s products include Cerenis delta compounds which reverse atherosclerotic disease by enhancing natural cardioprotective mechanism in humans. Developer of drugs for treating increasingly drug-resistant conditions, like influenza, hepatitis C and HIV. 57.87 CM-CIC Securities 22.49 Shore Capital Developer of medical devices for delivering injectable therapeutic drugs. The company’s products are pre-filled drug-infusion patches that will be sold in conjunction with a series of pharma and device companies. 39.95 Wells Fargo Securities, RBC Capital Markets Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 1 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Adient Medical Last Financing Date HQ Location Round 9-Mar-15 Pearland, TX Seed Advanced Catheter Therapies 17-Mar-2015 Aeglea BioTherapeutics Holdings 23-Mar-2015 Alize Pharma 17-Mar-2015 Allergen Research APR Applied Pharma Research Aura Biosciences Auxogyn 12-Mar-15 25-Mar-2015 5-Mar-15 18-Mar-2015 Description Last Financing Size ($ millions) Lead Investor(s) Developer of absorbable medical devices that vanish without Undisclosed TMCx Accelerator intervention after use. The company provides vascular filter for the prevention of pulmonary embolism. Chattanooga, B Developer of medical device and catheter technologies for the 4.50 ACT I Investments, TN treatment of vascular diseases and restenosis. The company focuses on Chattanooga moving the patented Occlusion Perfusion Catheter (OPC), an Renaissance Fund, intravascular agent delivery device, to sale or out-licensing. Maclellan Foundation Austin, TX B Provider of drugs for the treatment of cancer. The company engages in 44.00 Lilly Ventures, clinical development of engineered human enzymes and developing Novartis Venture therapeutic enzymes for oncology. Its lead drug candidate AEB1102 is Fund being developed as an enzyme replacement therapy in patients with the inborn errorofmetabolism hyperargininemia that isand caused by Arginase Ecully, France Later Developer biopharmaceutical drugs, proteins peptides. The I 1.95 Sofimac Partners, company develops therapeutic products for the treatment of diabetes, Octalfa, Sham cancer and metabolic diseases. Innovation Santé San Mateo, CA B Developer of immunotherapy for food allergies. The company 80.00 Foresite Capital develops treatments to protect children with food allergies from the consequences of accidental exposure. Balerna, PE Growth Developer of healthcare products. The company engages in the Undisclosed HBM Partners Switzerland development of oral and topical formulations, OTC pharmaceuticals, nutraceuticals, dermocosmetics and medical devices. It also offers consumer healthcare products for acute pain, cough & cold, insect repellent, intimate care, legs healthcare, pediatric, pregnancy and proctology. Cambridge, MA B Developer of nanotechnology drug delivery systems for the treatment 21.02 Advent Life of cancer. The company has developed a platform based on viral Sciences nanoparticles for the treatment of cancer. Menlo Park, CA B Developer of a medical technology for advancing women’s 34.32 Undisclosed reproductive health through scientific and clinical knowledge of early human developmental biology. The company provides quantitative information regarding embryo development to assist IVF clinicians in optimizing the treatment path for their patients. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 2 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Size ($ millions) Lead Investor(s) 17.98 Undisclosed Last Financing Date HQ Location Round Balance Therapeutics 18-Mar-2015 San Bruno, CA B Beta-O2 Technologies 30-Mar-2015 Rosh-Haayin, Israel Later BioWink 18-Mar-2015 Berlin, Germany Early Developer of a fertility tracking application. The company enables users to track their monthly cycle by entering data on various segments. BrainCheck 9-Mar-15 Houston, TX Seed Brainstage 26-Mar-2015 Carnegie, PA A Cadence Biomedical 24-Mar-2015 Seattle, WA Later Cardiac Dimensions 11-Mar-15 Kirkland, WA Tenth Caribou Biosciences 24-Mar-2015 Berkeley, CA A Catabasis Pharmaceuticals 17-Mar-2015 Cambridge, MA B 3-Mar-15 Redmond, WA Fifth Developer of a brain diagnosis device. The company develops a device Undisclosed TMCx Accelerator that helps in measurement of brain function designed to aid in the diagnosis of traumatic brain injury. Provider of process and cost improvements to the pharmacopeia and 2.20 Undisclosed healthcare industries. The company is focused to provide innovative and advanced technologies for gene expression and cell diagnostics, toxicity analysis, personalized genomic medicine, drug discovery and development biomedical Developer of and medical devices.bioinformatics. The company offers the Kickstart 0.96 Undisclosed Walking System, a neurorehabilitation system to retrain walking following stroke, incomplete spinal cord injury, and many other neurological conditions. Manufacturer of devices for the treatment of heart failure and related 43.70 Life Sciences conditions. The company develops minimally invasive implantable Partners, Aperture products to treat mitral valve regurgitation associated with congestive Venture Partners, heart failure. also provides technology CARILLON Contour System, Arboretum Developer ofItCRISPR-Cas9 forMitral precision cell engineering. 11.55 Fidelity Biosciences The company offers technology-based services for cellular engineering and analysis based on the CRISPR-Cas9 technology platform. Developer of drugs to treat inflammatory condition and metabolic 12.41 Undisclosed diseases. The company's technology enables the discovery and development of small molecules that simultaneously target pathways in the inflammatory Developer of toolsresponse. for the treatment of ischemic stroke and other 11.38 Undisclosed vascular disorders. The company develops treatment for acute ischemic stroke using a combination therapy, known as sonothrombolyis. Company Name Cerevast Therapeutics Description Developer of therapeutics for Down's Syndrome and Alzheimer’s disease. The company provides therapeutics to address conditions of intellectual disability. Provider of a proprietary implantable bioartificial pancreas. The company provides a proprietary implantable bioreactor to be used as a treatment and cure for type 1 diabetes. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Undisclosed Sherpa Innoventures 2.00 Brigitte Mohn, French Groupe Arnault, DR. KADE 3 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round Description Last Financing Size ($ millions) Lead Investor(s) Undisclosed TMCx Accelerator Clear Ear 9-Mar-15 San Francisco, CA Seed Developer of medical devices for cleaning ears. The company offers medical devices that soften and remove ear wax. Collegium Pharmaceutical 10-Mar-15 Canton, MA Ninth Convergent Dental 31-Mar-2015 Natick, MA B1 Daktari Diagnostics 2-Mar-15 Cambridge, MA D 19-Mar-2015 Plano, TX Later Developer of treatments for chronic pain. The company also develops 50.00 TPG Biotech and commercializes products for skin and skin related illnesses and disorders. Developer of a computer-guided tooth preparation system. The 9.00 Long River company is a dental equipment and technology company and developer Ventures, George of Solea, a computer-aided, CO2 laser system for both hard and soft Gund Foundation tissue indications. Developer of products that provide diagnostic information to clinicians 15.50 Eastern Capital and patients. The company is developing CD4, a handheld instrument Limited and Merck that offers electrical reading and reports of test results. Global Health Fund Developer of a dental diagnostic technology. The company develops Undisclosed Innovation Undisclosed diagnostic technology that integrates LEDs, advanced optics and digital electronics into devices to improve and advance the care of dental patients. 12-Mar-15 Hillsboro, OR C 24-Mar-2015 San Carlos, CA A1 DentLight DiabetOmics Eiger BioPharmaceuticals Developer of applications and technology to improve the diagnosis and monitoring of diabetes and its complications. The company's tests and services include gestational diabetes profile and personalized wellness profile withoflaboratory tests toagainst identify problem areas. Developer antiviral agents novel targets in the treatment of hepatitis. The company focuses on the development of treatments for strains of hepatitis. The company's pipeline includes preclinical new chemical entities (NCEs)that is shown to possess antiviral activity against Hepatitis C, Hepatitis D, and a wide array of other viruses. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 5.00 Ventureast and KI Varaprasad Reddy 14.46 Undisclosed 4 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Date HQ Location Round 12-Mar-15 Berkeley, CA Third Emergency Medicine Scribe Systems EndoChoice 31-Mar-2015 El Segundo, CA A2 5-Mar-15 Alpharetta, GA Seventh Fitbit 27-Mar-2015 San Francisco, CA Later Flower Orthopedics 23-Mar-2015 Horsham, PA C Gauss Surgical 9-Mar-15 Los Altos, CA Seed Genprex 4-Mar-15 Austin, TX Second 18-Mar-2015 Boston, MA A Company Name Eko Devices Ginkgo Bioworks Description Last Financing Size ($ millions) Lead Investor(s) Developer of an application to record heart sound. The company 2.00 Founder.org allows doctors to visualize the audio waveform, record and playback heart sounds and export them through email or electronic health records. It helps doctors diagnose heart defects by transforming the stethoscope into a powerful tool that can share, annotate and analyze heart sounds Provider of staff scribing services to hospitals and physicians. The 1.05 Undisclosed company is a professional scribe staffing and training service for healthcare providers. Its services include transcriptions(GI) of medical Developer of technologies focused on gastrointestinal endoscopy. 57.00 Deerfield The company provides devices, diagnostics, infection control and imaging for specialists treating of gastrointestinal diseases. Developer of digital health and fitness devices. The company is the 17.82 Undisclosed developer of a family of mobile devices enabling users to make fitness goals and track their progress, sharing their achievements with an online community of users. The products include wireless trackers, a WI-Fipowered scale and a suite of mobile-application tools. Developer and manufacturer of implants for orthopedic surgery 4.50 Undisclosed products. The company develops pre-sterilized, bone-fixation and implant products for orthopedic surgery. Developer of a mobile computer vision platform to monitor surgical Undisclosed TMCx Accelerator blood loss in real time. The company is developing mobile applications, cloud based computing and artificial intelligence to provide information to assist the clinician in intraoperative fluid management and blood transfusion. Developer of clinical-stage bio-pharmaceutical products for cancer 0.16 Undisclosed therapy. The company's leading product is Oncoprex and is a pankinase inhibitor that works to induce apoptosis in cancer cells and control cell inflammatory pathways to treat cancer at the Provider of signaling biologicaland engineering services. The company provides 9.00 Felicis Ventures, OS biology technologies to design, build and test new organisms across a Fund, Data range of industries from fuels to pharmaceutical production. Collective, iGlobe Partners, Vast Ventures Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 5 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Size ($ millions) Last Financing Date HQ Location Round Description Glooko 17-Mar-2015 Palo Alto, CA B 16.50 Medtronic, Canaan Partners GrayBug 5-Mar-15 Baltimore, MD Fouth Creator of diabetes-management application. The company provides an HIPPAA-compliant diabetes management system enabling users to download data from their glucose meters into their mobile device, creating intelligence that can be shared and notated. Information uploaded patient cansystems be shared providerThe through the Developerbyofthe drug delivery to with treat their eye diseases. company’s lead product is a polymer-drug biomolecular conjugate for the treatment of neovascular diseases, including age-related macular degeneration (AMD). 1.74 Hatteras Venture Partners Guardant Health 27-Mar-2015 Redwood City, CA C 55.90 Lightspeed Venture Partners Healint 31-Mar-2015 Singapoore, Singapore Seed 1.00 Wavemaker Pacific Health Catalyst 17-Mar-2015 Salt Lake City, UT D Provider of digital sequencing technology for blood tests. The company develops a blood test for cancer that helps identify tumor genomic alterations in real time. Developer of a remote monitoring system for physicians. The company's technology allows doctors and health stakeholders to take advantage of mobile devices, sensors, machine learning and big data for the management of chronic diseases. Provider of healthcare data warehousing and analytics. The company provides an analytics platform, data warehousing and process improvement services for healthcare organizations and health systems. 70.00 Northwest Venture Partners Healthentic 19-Mar-2015 Seattle, WA Later Operator of a health care analytics company. The company offers data analytic services that identifies health savings for employers. 3.75 HealthFinch 16-Mar-2015 Madison, WI Later Developer of a platform of applications to help doctors address inefficiencies with their workflow that are not being addressed by the current EMR solutions. The company's product allows physicians to define custom protocols for medication refills allowing subsequent access by their team. 2.40 Corvesta, Hawaii Dental Service, WDS Holdings, WYSSTA Jumpstart Ventures Company Name Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Lead Investor(s) 6 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round Description Provider of a communication platform connecting doctors to patients. The company provides a cloud-based platform that automates followup care and is designed to keep doctors, patients and caregivers connected between visits, with actionable clinical information. The company's peer-reviewed follow-up plans automate the routine aspects of care while tracking patient progress and monitoring clinical areas ofon Provider of healthcare informatics services. The company is focused bringing evidence-based imaging analysis to the point of care. 13.15 Canvas Venture Fund 4.50 Venture Investors and 4490 Ventures Provider of a healthcare application. The company offers a mobile application which enables users to manage their medical records and share them online with the doctors. Developer of orthopedic medical devices. The company develops products which includes a surgical tool that measures the position and orientation of hip implants and provides a digital readout. Developer of therapies to treat chronic venous insufficiency. The company has developed a non-implantable, catheter based therapy, that creates new valves out of the patient's native vein wall tissue. 1.30 Resolute Ventures 0.55 FedDev Ontario 5.92 Boston Scientific Developer of surgical visualization and illumination technology for applications in minimally invasive surgeries. The company offers BriteField Port System that provides illumination and visualization during minimally invasive procedures; and BriteField McCulloch retractor, which allows physicians to achieve visualization during surgery while traditional techniques. Operator of a using healthcare-information services company. The company provides a platform and device for long-term continuous cardiac monitoring, to enable diagnosis earlier in the clinical pathway. The company'sofwearable products can monitor heart rhythms forNASA up to 14 Provider balance diagnostics devices. The company uses technology to develop a scale that can track balance and is designed to Developer of chronic disease therapeutics. The company is focused on the discovery and development of molecules that modulate key regulatory networks associated with chronic disease. 22.89 Wellington Management Company 27.34 Novo A/S Undisclosed 5.50 TMCx Accelerator Polaris Partners HealthLoop 11-Mar-15 Mountain View, CA A HealthMyne 10-Mar-15 Madison, WI A 26-Mar-2015 Tel-Aviv, Israel Early 5-Mar-15 Waterloo, Canada Third 19-Mar-2015 Mountain View, CA A Invuity 9-Mar-15 San Francisco, CA Sixth iRhythm Technologies 12-Mar-15 San Francisco, CA E iShoe KinDex Pharmaceuticals 9-Mar-15 6-Mar-15 Houston, TX Seattle, WA Seed A Hello Doctor (Mobile Application) Intellijoint Surgical InterVene Last Financing Size ($ millions) Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Lead Investor(s) 7 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round Description 4-Mar-15 Aachen, Germany Second 26-Mar-2015 Oakland, CA B Lucigen 13-Mar-15 Middleton, WI Angel Provider of software products for image processing in biology and medicine. The company provides an automatic detection and analysis software tool to find number of collembols after flotation along with Microbiology, an automatic detection and analysis tool for the detection of colonies and colony counters. Provider of cloud-based information feedback technology to save energy and water in buildings. The company pioneered behavioral efficiency and occupant engagement technology in commercial buildings and the first vendor-neutral “operating system” for commercial buildings with BuildingOS. The cloud-based software creates a central information hub for building system, meter, and device data while reducing integration costs. Developer of life science research products and technologies for genetic cloning. The company develops technologies for advancements in DNA cloning, sequencing, amplification, and protein expression. Luneau Technology 5-Mar-15 Madison Vaccines 10-Mar-15 Medical Adhesive Revolution 9-Mar-15 Mersana Therapeutics 2-Mar-15 LemnaTec Lucid Design Group Last Financing Size ($ millions) Lead Investor(s) 5.60 Anterra Capital 14.12 Formation 8 2.23 Undisclosed Pont de l’Arche, PE Growth Developer of ophthalmic diagnostic equipment. The company Undisclosed MML Capital France manufactures and distributes equipment from the visual diagnosis to Partners, BNP the manufacture of optical glass, used by ophthalmologists and Paribas, Amundi and opticians. Credit Agricole Madison, WI A Developer of DNA-vaccine products for the treatment of prostate 11.00 Venture Investors cancer. The company is developing treatments designed to stimulate a prostate cancer patient's immune system to destroy residual tumor cells before they develop into overt bone metastases and to delay the need for castration therapies. Aachen, Seed Manufacturer of medicinal adhesives. The company develops and Undisclosed TMCx Accelerator Germany commercializes biodegradable surgical adhesive that can be used on the skin and inside the human body to close wounds. Cambridge, MA B1 Developer of biodegradable and bio inert material for drug protection. 35.00 New Enterprise The company's products conjugate for the treatment of multiple tumor Associates types and various preclinical oncology compounds. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 8 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round MHB Labs 18-Mar-2015 Chestnut Hill, MA Seed Microscopy Innovations 19-Mar-2015 Marshfield, WI Later MindMaze 4-Mar-15 Ecublens, Switzerland Angel Minimally Invasive Devices 6-Mar-15 Columbus, OH C Modernizing Medicine 20-Mar-2015 Boca Raton, FL D MSI Methylation Sciences MuscleSound 23-Mar-2015 Burnaby, Canada Later 11-Mar-15 Denver, CO Seed MySugr 11-Mar-15 Vienna, Austria Seed NanoLinea 9-Mar-15 Houston, TX Seed Description Last Financing Size ($ millions) Lead Investor(s) Developer of medical products for management of erectile dysfunction. 1.10 Romulus Capital The company develops pharmaceutical products for the management of erectile dysfunction and anorgasmia. Developer of novel products for microscopy laboratories. The 0.75 Undisclosed company offers tools for the life science market lowering total processing costs, improving turn-around time, and reducing error rates, chemical usage and disposals. Developer of a virtual reality (VR), augmented reality and motion 8.50 Undisclosed capture game system, MindLeap. The company develops a product that combines immersive virtual reality, motion capture and neurophysiological recording technologies to build novel interfaces for neurorehabilitation, game training andvision threesystem. dimensional imaging in real Developer of FloShield laparoscopic The company 11.70 Canaan Partners, develops a device that prevents loss of vision during laparoscopic Charter Life surgery due to obscuration of the optics. Sciences Developer of a cloud-based specialty-specific electronic medical record 20.00 Summit Partners, system. The company's Electronic Medical Assistant product is used Pentland Group and built by practicing physicians to gather healthcare information and improve outcomes It also provide additional facilities like specialtyspecific billing, inventory management purchasing services. Operator of a biotechnology company. and Thegroup company develops and 0.02 Undisclosed markets a prescription drug used as a dietary supplement. Developer of a technology to measure muscle glycogen. The company 4.30 Undisclosed develops software, technology and methodology for measurement of muscle glycogen levels and generates muscle-specific data reflective of current muscle glycogen levels. Developer of a diabetes monitoring application for smartphones. The 4.80 XLHealth, Roche company offers an application that uses optical character recognition Ventures, and iSeed (OCR) software to use the smartphone’s camera to read the glucose Ventures reading number off the display screen of a connected blood glucose meter and save it to the application. Provider of therapeutic implant treatment for cardiac ventricular Undisclosed TMCx Accelerator arrhythmia. The company creates medical devices based on carbon nanotube fiber technology. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 9 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Date HQ Location Round Neurovance 24-Mar-2015 Cambridge, MA A1 NGM Biopharmaceuticals 26-Mar-2015 South San Francisco, CA D Nightingale App 24-Mar-2015 Boston, MA Seed Nimbus Therapeutics 18-Mar-2015 Cambridge, MA Ninox Medical 29-Mar-2015 Novan NuScriptRX Company Name Description Developer of a norepinephrine and dopamine-preferring reuptake inhibitor for attention deficit hyperactivity disorder. The company develops EB-1020 for adult attention deficit hyperactivity disorder (ADHD) and a pipeline of research compounds for other CNS disorders. Developer of transformational biologics for the treatment of diabetes, obesity and other cardio-metabolic diseases. The company develops biotherapeutics to identify and validate novel targets that impact the underlying etiology of metabolic diseases. Last Financing Size ($ millions) Lead Investor(s) 20.00 Novartis Venture Fund 257.50 Merck Provider of a mobile application to manage prescriptions. The company offers a mobile application for patients and their caregivers that learns the patient's schedule and reminds them to take their prescriptions. 0.66 Maverick Capital, Stanford-StartX fund, Y Combinator, Keith Rabois and Jaan Tallinn B Developer of biopharmaceutical products. The company is developing biopharmaceutical products to diffuse large B-cell lymphoma, an aggressive blood cancer, inflammatory disorders and metabolic disease. 43.00 Pfizer Venture Investments, Lightstone Ventures Rishon LeZion, Israel Early 10.00 Xenia Venture Capital 27-Mar-2015 Durham, NC Later 50.00 Malin Corporation 18-Mar-2015 Nashville, TN D1 Developer of a device for treating obstructive sleep apnea. The company's device is designed to be effective, comfortable to use and without the side effects. Developer of therapeutic agents. The company develops products that tap the anti-bacterial properties of nitric oxide by encapsulating the compound in nano-particles that deliver therapeutic agents to desired body location. Provider of institutional pharmacy services. The company offers medication dispensing model which has an utomated robotic system for dispensing pharmaceuticals on a short cycle basis, providing medications in specialized unit dose patient packaging. 3.85 Undisclosed Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 10 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Date HQ Location Round 12-Mar-15 Louisville, KY Second ODOS Industries 18-Mar-2015 Mansfield Center, CT Angel OrthoSensor 23-Mar-2015 Dania Beach, FL C Ovid Therapeutics Oxitone Medical 16-Mar-2015 9-Mar-15 New York, NY Kfar Saba, Israel Angel Seed Patient Route Systems 26-Mar-2015 Newton, MA A Pear Therapeutics 19-Mar-2015 Boston, MA Early Perceptimed 25-Mar-2015 Mountain View, CA A2 Company Name NX Pharmagen Description Last Financing Size ($ millions) Lead Investor(s) Developer of blood-based molecular diagnostic testing products for 1.81 XLerate Health cancer, prenatal care and various other conditions. The company provides NeXosome, a prenatal and oncology diagnostics proteomics platform that permits analysis of protein biomarkers shed specifically from placental or tumor cells within protected exosomes (or microvesicles) and harvested from blood samples. Developer of electronic medical records system. The company's 0.28 Undisclosed technology helps to maintain documenting patient encounters and managing clinical information. 19.00 Bridger Healthcare Developer of orthopedic implants and sensor-assisted surgery systems. Ltd, Tullis Growth The company’s sensor platform helps in external and implanted sensors Fund which can detect and monitor various functions in the musculoskeletal system. Developer of drugs for orphan diseases of the brain. 5.06 Undisclosed Developer of wrist worn health monitoring system without fingertip Undisclosed GEFEN Biomed probe. The company's product enables continuous monitoring Investments, anywhere, anytime and alerting in emergency situations. StartUp Health, and TMCx Accelerator Provider of a healthcare operations platform. The company offers an 7.00 Black Granite online platform that enables doctors to schedule their surgeries, Capital, Pierpoint collaborate with patients and optimize resource utilization in hospitals. Capital Developer of digital health interventions to enhance the efficacy of Undisclosed pharmaceutical preparations. The company provides an online platform designed for patients to access while they are taking their prescriptions. The platform provides patients with information about their prescription, with patient feedback to physicians, fine tune the Developer ofalong an advanced pill identification system. Thetocompany 5.36 provides IdentRx, a small device that determines the medication and dosage of individual pills in real-time, checks each pill in a medication pass against the doctor’s prescription. It also offers products for prescription drug verification, pharmacy remote verification and will- Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 5AM Ventures Undisclosed 11 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name PhaseBio Pharmaceuticals Pherecydes Pharma PhoreMost Portsmouth Regional Ambulatory Surgery Center Provista Diagnostics Pulmokine Last Financing Date HQ Location Round Description 12-Mar-15 Malvern, PA C 18-Mar-2015 Romainville, France Early 11-Mar-15 Cambridge, United Kingdom Seed 24-Mar-2015 Portsmouth, NH Angel 16-Mar-2015 New York, NY Later 4-Mar-15 Rensselaer, NY First Developer of biopharmaceuticals for metabolic and specialty cardiopulmonary disorders. The company has developed once-weekly insulin for type 2 diabetes and once-weekly Vasoactive Intestinal Peptide for heart failure and cardiomyopahty in Duchenne and Becker muscular dystrophy. Developer of new products against emerging bacteria, combining surveillance, detection and therapeutic tools based on phage technology. The company develop new tools to rapidly detect and treat people and their environment against a large range of biothreat agents, including multi-resistant, emergent or previously uncharacterized bacteria. Developer of targeted drug therapies. The company is focused on discovering drug therapies for disease targets intractable to current drugdiscovery technology. The company is the developer of a live-cell phenotypic assay system that can rapidly identify unexpected, or “cryptic” druggable sites in specific disease-driving targets and pathways be center. readily The seencompany using conventional non-cellsurgical based Operator that of a can’t surgery offers ambulatory healthcare services in the areas of orthopedic, ophthalmology, ears, Provider of oncology-based nose, throat, gynecology anddiagnostic podiatry. tests and clinical laboratory services to the pharmaceutical and biotechnology industries. The company offers blood-based diagnostic tests for early oncology-related disease state recognition and detection purposes. Its dtectDx-Breast detects biomarkers using a blood sample which, when used in Developer of new therapies for lung conditions like pulmonary arterial hypertension (PAH) and related disorders. The company offers their proprietary discoveries and solutions to other companies in their field, and iss also developing a novel class of kinase inhibitors through insilico modeling and in-vitro screening. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Last Financing Size ($ millions) Lead Investor(s) 40.00 AstraZeneca 2.82 ACE Management Equity Partners 3.80 Jonathan Milner, Sunil Shah, Prashant Shah and Amadeus Capital Partners 0.64 Undisclosed 3.87 Undisclosed 1.00 Broadview Ventures 12 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Financing Size ($ millions) Last Financing Date HQ Location Round Description 10-Mar-15 Hayward, CA B Developer of solid-state ultraviolet (SSUV) LED technology. The company provides patent-protected UV LED technology and materials, with application for UV disinfection of water and air, and for UV medical treatment devices. 9.30 RightClinic 19-Mar-2015 London, United Kingdom Early 0.37 Rigontec 24-Mar-2015 Bonn, Germany A Developer of an online booking platform for health and beauty clinics. The company offers an online platform using which its users can book appointments for laser eye surgery, cosmetic surgery, dental clinics, browse deals and offers, check ratings and reviews of the people and ask their queries in a forum. Operator of a biotechnology company. The company develops proprietary retinoic acid inducible gene I (RIG-I) activators for the treatment of cancer. Secure EDI 27-Mar-2015 Charlotte, NC Later Semma Therapeutics 24-Mar-2015 Cambridge, MA A Silicone Arts Laboratories 24-Mar-2015 Memphis, TN A 9-Mar-15 La Jolla, CA Seed Company Name Rayvio Skylit Provider of software that interfaces among healthcare and dental providers and payers. The company develops web-based services that increases efficiency and helps to reduce costs through real-time adjudication of claims, electronic funds transfers, on-line reconciliation and data mining and informatics. Developer of transformative therapies for type 1 diabetes patients. The company offers a device to provide replacement for the missing beta cells in a diabetic immunosuppression. Manufacturer of apatient topicalwithout filler called Dermaflage. The company uses silicone to simulate skin and instantly conceal recessed imperfections. Developer of a phototherapy device. The company develops a phototherapy device that helps in the treatment of patients with psoriasis, vitiligo and eczema diseases. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Lead Investor(s) Applied Ventures, Augment Ventures, New Ground Ventures, Tolero Ventures, DCM Ventures Forward Partners 15.44 Wellington Partners, Boehringer Ingelheim Venture Partners 8.81 Undisclosed 44.00 MPM Capital 1.50 Innova Memphis Undisclosed EvoNexus, Founder.org, and TMCx Accelerator 13 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round Sonormed 31-Mar-2015 Hamburg, Germany A StratoScientific 20-Mar-2015 Seattle, WA Angel Svelte Medical Systems 19-Mar-2015 New Providence, NJ Later Swallow Solutions 13-Mar-15 Madison, WI A TeleSkin 10-Mar-15 Belgrade, Serbia Second 31-Mar-2015 Montreal, Canada D Thrasos Therapeutics Description Developer of a therapy for treatment of tinnitus. The company develops an audiology technology that offers neuroacoustic treatment for ringing in the ears. Developer of medical devices. The company develops devices that are used in medical practices. The portfolio of products includes the StethIO, a smartphone stethoscope for visualizing and hearing heart sounds and the LesionSizer, a device to decrease stents in angioplasty due to inaccurate lesion length measurement. Developer of balloon expandable stents. The company designs and develops non thrombogenic and non inflammatory drug eluting stents for the treatment of atherosclerosis. Operator of life sciences company with a dysphagia treatment platform. The company focuses on two areas related to dysphagia – therapeutic devices for diagnosing and treating swallowing disorders and nutritional food products tailored to the patient’s diagnosed level of swallowing difficulty. Provider of a clinical skin cancer analysis platform. The company offers hardware and software services with a clinical multi-spectral dermascope for the medical practioner to conduct a detailed dermascopic analysis of moles and other skin lesions. Developer of therapies for the prevention and treatment of severe organ failure with a principal focus on kidney disease. The company's lead therapeutic program, THR-184, is focused on the prevention and treatment of acute kidney injury (AKI). It also has a preclinical development program for treating chronic kidney disease (CKD). Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Last Financing Size ($ millions) Lead Investor(s) Undisclosed High-Tech Gründerfonds, Innovationsstarter Fonds Hamburg, Quotas Beteiligungs and Heiko Hubertz 0.70 Undisclosed 38.00 CNF Investments 2.06 Venture Management 0.94 SEED Capital Denmark and Accelerace 21.00 SR One, BDC Capital 14 Monthly Healthcare Review March 2015 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Company Name Last Financing Date HQ Location Round Description Operator of a bio-pharmaceutical company. The company focuses on the discovery and development of first-in-class therapeutics for kidney diseases. Developer and provider of medical devices. The company provides a mobile-connected 12-lead ECG. The 12 leads role up into a package and, combined with the app, are designed to allow doctors to take ECG readings on the go — in home care settings, in transit between care settings, or of in an global health contexts. Developer immunotherapy treatment for the treatment of brain and kidney cancers. The company is focused on cancer cell vacination and T-cell cancer treatment. Operator of a biotechnology company. The company is a provider of translational genomics services. Operator of a medical device company that engages in developing, manufacturing and marketing stents to treat chronic venous diseases. The company offers Vici Venous Stent System that is used to treat venous outflow obstruction in the lower extremities. Tricida 4-Mar-15 South San Francisco, CA B Triomi Medical Innovations 9-Mar-15 Miami, FL Seed 30-Mar-2015 Lenexa, KS Later UberSeq 10-Mar-15 Palo Alto, CA Seed Veniti Medical 10-Mar-15 St. Louis, MO C TVAX Biomedical Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Last Financing Size ($ millions) Lead Investor(s) 30.00 OrbiMed 0.12 Sprint Accelerator 2.00 Undisclosed 0.38 Undisclosed 17.00 Baird Capital, Tekla Healthcare, and Tekla Life Science Investors 15 Monthly Healthcare Review March 2015 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Acquirer Target HQ Location 3M Ivera Medical San Diego, CA 4d pharma GT Biologics Aberdeen, United Kingdom Amplifon Dilworth Hearing Auckland, New Zealand Baxter International SuppreMol Munich, Germany Becton Dickinson & Company Crisi Medical Systems San Diego, CA Biosafe Group Biosafe Brasil Distribuidora Brazil CreatiVasc Medical Greenville, SC Marlin Equity Partners Austin, TX Brookhaven Medical e-MDs Date Target Description Transaction Value ($ millions) 13-Mar-2015 Developer and seller of disinfection products to reduce hospital acquired Undisclosed infections. The company specializes in the design, development, manufacturing, marketing and selling of the Curos line of products including passive disinfection port protectors that disinfect and then cover needleless valves to prevent contamination between venous accesses. 30-Mar-2015 Developer of Biotherapeutics for the treatment of autoimmune diseases. The 1.2 company develops approved Biotherapeutic products with proven efficacy for the treatment and management of debilitating paediatric inflammatory bowel diseases and other autoimmune diseases. 19-Mar-2015 Provider of hearing products and services. The company provides hearing-aids Undisclosed and related products such as batteries, accessories, spare parts and services. 04-Mar-2015 Developer of therapeutics for the treatment of autoimmune diseases and allergic 225.00 diseases. The company is focused on development of soluble Fc-gamma receptors (FcyRs), which are recombinant autologous therapeutic proteins with a specific immunoregulatory potential. 02-Mar-2015 Developer of drug-delivery systems. The company's products are designed to Undisclosed improve clinical outcomes and lower healthcare costs by making the delivery of intravenous injectable drugs safer and more accurate. 30-Mar-2015 Distributor of cell processing systems. The company is primarily engaged in Undisclosed distribution of regenerative medicine, stem cells banking and automated cell processing systems for the medical industry. 10-Mar-2015 Developer of medical devices for the treatment of end stage renal diseases. The company develops vascular technologies that addresses the problems of kidney dialysis connectivity. 31-Mar-2015 Developer of integrated electronic health records and practice management software. The company is an industry leader for usable, connected software that enables physician productivity and a superior clinical experience. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Undisclosed Undisclosed 16 Monthly Healthcare Review March 2015 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Acquirer Target HQ Location InKaryo Mountain View, CA CUI International Leicester, United Kingdom Healthstream HealthLine Systems San Bernardino, CA Hinduja Global Solutions Limited Colibrium Partners Roswell, GA Impax Laboratories Amedra Pharmaceuticals Horsham, PA Impax Laboratories CorePharma Middlesex, NJ Impax Laboratories Lineage Therapeutics Horsham, PA Intelligent Hospital Systems Amerisource Bergen Technology Group Buffalo Grove, IL Esperite H&R Healthcare Date Target Description 19-Mar-2015 Provider of cytogenetic analysis services. The company's experimental protocol and proprietary bioinformatics analysis cover the full genome evenly with specific and accurate digital sequence output thus providing next generation sequencing platforms, sequencing reagents, sequencing applications, genomic diagnostics, and bioinformatics. 23-Mar-2015 Manufacturer of specialist medical support products. The company designs and develops parastomal hernia support products and specialist stoma underwear. 17-Mar-2015 Provider of credentialing software, contact center software and quality management software to hospitals and healthcare organizations. The company also provides web-based credentialing software. 30-Mar-2015 Provider of software products to the healthcare industry. The company offers CRM systems, management consulting, database software, health plan automation and wellness automation platform software and services. 10-Mar-2015 Provider of prescription products in the United States. The company offers an emergency injection of epinephrine used for the treatment of life-threatening allergic reactions known as anaphylaxis. 10-Mar-2015 Developer and manufacturer of solid dose generic pharmaceuticals, including prescription and over-the-counter products. The company focuses on solid oral dosage forms, both modified and immediate release dosage forms and controlled drug products.ofIt pharmaceutical manufactures and handlesThe C-II, C-III, C-IV and C-V 10-Mar-2015 Manufacturer products. company develops and drugs, as manufactures injections, capsules and tablets used for severe swelling, breathing problems and loss of blood pressure. 09-Mar-2015 Provider of pharmacy and medical automation services. The business unit offers pharmacies dispensing, multi-facility health systems, streamline medication management processes and control costs. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Transaction Value ($ millions) 40 Undisclosed 88 Undisclosed Undisclosed Undisclosed Undisclosed Undisclosed 17 Monthly Healthcare Review March 2015 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Acquirer Target HQ Location XO1 Cambridge, United Kingdom Kite Pharma Kite Pharma EU Haarlem, Netherlands Meadowlark Optics Cambridge Research & Instrumentation (Product line) Streamline (Healthcare) Frederick, CO Janssen Pharmaceuticals Medovex Medtronic Sophono Merry X-Ray Corporation Lupica Medical Systems NTC Pharma Wise SGR Paragon Partners Medentech Pharmalink Prestium Pharma Synartro Zonalon (MEDICATED SKIN CREAM) Date Target Description Developer of anticoagulant drugs to prevent heart attack and stroke without 19-Mar-2015 causing bleeding. The company develops ichorcumab drugs and operates virtually by engaging contract research and development specialists in Europe and the US, managed by a small team of experienced drug developers. 18-Mar-2015 Provider of gene therapy services. The company specializes in providing gene therapy platforms for the treatment of cancer. 26-Mar-2015 Provider of multi-spectral diagnostic imaging services. The business division designs and manufactures liquid crystal 1x128 and 1x640 spatial light modulator. It is an electrically programmable device that modulate light in a fixed spatial Developer of medical intravenous transport system. The company provides the (pixel) pattern. Eden Prairie, MN 26-Mar-2015 Streamline IV (intravenous) Suspension System (ISS), a multipurpose transport system that combines the advantages of both stand-alone and bed-mounted IV poles in one system. The ISS pole is designed to attach and lock to any transport Boulder, CO 26-Mar-2015 Developer of implantable bone conduction hearing devices. The company provides hearing devices for individuals suffering from severe to profound hearing loss and impairment. North Royalton, OH 23-Mar-2015 Supplier of healthcare imaging equipment. The company provides x-ray equipment and film-processor accessories to hospitals, orthopedics, imaging centers, podiatrists, chiropractors and veterinarians. Milan, Italy 20-Mar-2015 Operator of an international pharmaceutical company. The company is active in the fields of niche generic pharmaceuticals and over-the-counter (OTC) drugs, as well as medical devices and food supplements. Wexford, Ireland 03-Mar-2015 Manufacturer of disinfection products. The company offers water purification tablet to prevent cholera, typhoid, dysentery and other water borne diseases. It also provides disinfectants, sterilizers and other related products for hospital, livestock and machinery markets. Uppsala, Sweden 18-Mar-2015 Developer of anti-inflammatory drug using the drug delivery technology. The company is involved in developing a pipeline of repositioned drug candidates for important medical needs. Hitchin, United Kingdom 18-Mar-2015 Rights to a pharmaceutical skin cream. The skin cream, Zonalon (doxepin hydrochloride) is used to treat itching from a range of skin conditions, including atopic cermatitis, eczema and neurodermatitis. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Transaction Value ($ millions) Undisclosed 20 Undisclosed Undisclosed Undisclosed Undisclosed Undisclosed Undisclosed Undisclosed Undisclosed 18 Monthly Healthcare Review March 2015 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Acquirer Target HQ Location HalioDx Marseille, France RoundTable Healthcare Partners Tower Holdings Horsham, PA Simplify Medical M.H. Carnegie & Co. Mountain View, CA Ranbaxy Laboratories (7666) Gurgaon, India Indus Meditech Delhi, India H-Net Zürich, Switzerland Whole You Respire Medical Holdings Brooklyn, NY WS Rothband Seneca Partners Rossendale, United Kingdom Qiagen Marseille Sun Pharmaceuticals Sunrise Asian Swisscom Date Target Description 23-Mar-2015 Provider of diagnostic services. The company develops, produces and markets a portfolio of diagnostic products focused on immuno-oncology. It also offers new treatments in the field of immuno-oncology. 10-Mar-2015 Developer of complex branded and generic pharmaceutical products. The Companies specialize in high value generic formulations including extendedrelease, delayed-release and DEA controlled substances 23-Mar-2015 Developer of cervical artificial disc that optimizes MRI imaging. The company operates several outpatient physical therapy clinics throughout Las Vegas Valley. Its simplify disc incorporates advanced materials to provide a metal free service, optimum imaging capability and kinematics. 25-Mar-2015 Owner and operator of a multinational pharmaceutical company. The company manufactures and markets generic, branded generic, value-added and over-thecounter products, anti-retrovirals, active pharmaceutical ingredients and intermediates. 25-Mar-2015 Seller and distributor of medicines to the pharmaceutical industry. The company is engaged in the clinical research, development and distribution of medicines to healthcare professionals and patients. 23-Mar-2015 Developer of database management software for the healthcare sector. The company provides digital data exchange and electronic invoicing services to hospitals, cantons, radiologists, physicians, laboratories and home care. 18-Mar-2015 Manufacturer of oral appliances. The company offers functional and aesthetic devices to help treat patients who snore, have Obstructive Sleep Apnea and Temporomandibular Joint Disorder symptoms. 24-Mar-2015 Manufacturer of equipment for radiology departments. The company manufacturers a range of lead-shielding products and equipment for radiology darkrooms and processing areas. Its products include lead aprons. mitts & protective curtains, as well as patient-positioning sets, imaging chairs and darkroom furniture. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com Transaction Value ($ millions) Undisclosed 700.00 Undisclosed 4,000 Undisclosed Undisclosed Undisclosed Undisclosed 19 Monthly Healthcare Review March 2015 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Acquirer ZeOmega Target HQ Location HealthUnity Bellevue, WA Date Target Description Transaction Value ($ millions) 23-Mar-2015 Provider of software products and services for health information exchange. The Undisclosed company provides a health information network that enables integrated delivery networks to create a longitudinal view of the patient's clinical information. Compiled By: Randall Hoyle Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, FinSMEs.com, fiercebiotech.com, PE HUB, and biospace.com 20