DATA SHEET
®
XDM Quad™ Single-Use Mixing System
The Xcellerex XDM Quad Mixing System is designed for convenient and
efficient mixing of buffer, media, product, and other process fluids. The single-use
system eliminates the hassle of time-consuming and costly clean-in-place (CIP),
steam-in-place (SIP), and cleaning validation. The result is more efficient processing
and rapid batch-to-batch turnover time.
The XDM Quad is comprised of a full-featured and integrated rigid containment
system complete with motor and controls, and an irradiated USP Class VI, singleuse LDPE fluid contact layer bag equipped with a disposable bottom-mounted
impeller. The engagement between motor and disposable impeller is via a robust
magnetic coupling, and agitation is driven through stainless steel bearings within
the impeller, imparting high torque and rapid mixing to the system.
The system delivers flexibility with the availability of two
standard bag types that include varying numbers of tubing lines
The XDM Quad Mixing System is
available in 50L, 100L , 200L, 500L and 1000L sizes.
Key Features
and connections, and sampling and sensing capabilities to ac-
l Powerful integrated magnetic agitator with compact VFD and AC motor
commodate a wide array of applications. Key features of the bag
l Optimized, disposable impeller
and rigid container also permit seamless transitioning between
powder-liquid and liquid-liquid mixing applications. The XDM
l Square configuration offers enhanced mixing efficiency through natural
baffling effect.
Quad Mixing System is available in either polypropylene, single-
l Workable heights and low center of gravity increase level of safety
wall stainless steel or or jacketed stainless steel (for heating and
l Bottom is slanted on two planes for extremely low bag hold-up volume
cooling applications).
l Compact unit with handles and casters for ease of mobility
l Fitted square bag minimizes bag wrinkles
l Real-time sensing and sampling capability via mixer window and bag probe
ports, sampling port and thermowell for non-invasive temperature sensing
l Integrated holders for 50ml conical buffer tubes
l Bags have integrated 3” Tri-clamp port for powder addition
l Translucent lid is included for protection of bag and is equipped with securing
feature for bag powder addition port and hopper
l 500L and 1,000L systems equipped with removable door for easy bag loading
l Two standard bag types: BASIC and PLUS (additional lines, probe ports, and connections)
l System also available in either polypropylene, single-wall stainless steel or
jacketed stainless steel (for heating and cooling applications).
l Fully wash-down rated
www.xcellerex.com • 1-866-Xcellerex
www.xcellerex.com • 1-866-Xcellerex
MOTOR/VFD
MATERIAL OF
CONSTRUCTION
WEIGHT
DIMENSIONS
NA
Jacket Volume
0.26
197
0-200
HP
Watts
RPM
Run/Stop, Forward/Break/Reverse
10 ft.
Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified
Power Cord
Washdown
304 lbs.
40.5 x 46.5 x 48
33 x 33 x 33
500 Liter
Functionality
115V or 230V: (50/60 Hz)
AC Motor
Electrical
183 lbs.
SS / Polyurethane (Non-Marring)
Type
Casters
Acrylic
NA
Insulation
Lid
Polypropylene
Container
143 lbs.
4x2
System Weight
(empty)
32.5 x 38 x 40
25 x 25 x 25
200 Liter
~0.5 per foot Cross-Section
27.5 x 33 x 41
20 x 20 x 20
100 Liter
Caster Dimensions
(ø x W)
115 lbs.
22.5 X 27 X 45
Exterior
(Inches LxWxH)
Slope to Drain
15.5 x 15.5 X 15.5
Container Interior
(Inches LxWxH)
50 Liter
XDM QUAD (Polypropylene) Systems
XDM Quad™ Mixers: SYSTEM SPECIFICATIONS
150 lbs.
21.375 X 33.375
X 42
15.5 x 15.5 X 15.5
50 Liter
10 ft.
Run/Stop, Forward/Break/Reverse
115V or 230V: (50/60 Hz)
0-200
197
0.26
AC Motor
33 x 33 x 33
500 Liter
397 lbs.
35.25 x 48.25 x
56.75
SS / Polyurethane (Non-Marring)
Acrylic
NA
304 Stainless Steel
309 lbs.
NA
4x2
~0.5 per foot Cross-Section
26.5 x 37 x 42
25 x 25 x 25
200 Liter
Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified
181 lbs.
24 x 33.5 x42
20 x 20 x 20
100 Liter
XDM QUAD-S (Stainless Steel) Systems
606 lbs.
43.25 x 55.25
x 56.75
41 x 41 x 41
1000 Liter
200 lbs.
1.2 L
236 lbs.
2L
26.75 X37x 42
20 x 20 x 20
100 Liter
38 .375 x 50.375
x 56.75
33 x 33 x 33
500 Liter
304 Stainless Steel
381 lbs.
2.65 L
4x2
503 lbs.
5.8 L
~0.5 per foot Cross-Section
26.75 x 38.5 x 42
25 x 25 x 25
200 Liter
Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified
10 ft.
Run/Stop, Forward/Break/Reverse
115V or 230V: (50/60 Hz)
0-200
197
0.26
AC Motor
SS / Polyurethane (Non-Marring)
Acrylic
792 lbs.
9.1 L
47.5 x 58.625 x
56.75
41 x 41 x 41
1000 Liter
Insulation is non-asbestos, chloride free and coated with Thurmalox mastic material
21.375 X 33.375
X 42
15.5 x 15.5 x 15.5
50 Liter
XDM QUAD-T (Jacketed Stainless Steel) Systems
All specifications are subject to change without notice.
SINGLE-USE BAG SPECIFICATIONS
All specifications are subject to change without notice.
50 Liter
100 Liter
200 Liter
500 Liter
1000 Liter
DIMENSIONS
Dimensions (inches LxWxH)
15.5 x 15.5 x 14.5
20 x 20 x 19
25 x 25 x 24
33 x 33 x 32
41 x 41 x 37
VOLUME
Maximum
55L
125 L
246 L
571 L
1019 L
Nominal
50L
100 L
200 L
500 L
1000 L
Minimum (Mix)
17 L
28 L
44 L
76 L
117 L
Hold Up
<20ml
< 20 mL
< 20 mL
< 20 mL
< 20 mL
FILM
Fluid Contact Layer
PRESSURE RATING
Maximum, operating
IMPELLER
# of Blades
LDPE (USP Class VI)
2 psi, 1 psi
3
Diameter
7.5”
Blade Height x Width
4.2” x 2.5”
Blade Pitch
57º
Material of Construction
Molded HDPE impeller with 316 SS bearing
TEMPERATURE RANGE
POWDER PORT
2º ­– 60ºC
Dimensions
3” TC
STERILIZATION
Gamma Irradiated
Bag Assembly DetailS
The XDM QUAD disposable impeller assembly is
welded to the bottom of the bag.
XDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS
SINGLE-USE BAG SPECIFICATIONS
BASIC BAG ASSEMBLY
Port
Description
A
Fill Port: 3 inch tri-clamp powder addition port, capped
B
C-flex® tubing, 4’ with clamp, plugged (ID indicated)
C
D
E, F
50L
100L
200L
500L
PLUS BAG ASSEMBLY
1000L
50L
100L
200L
500L
1000L
•
•
•
•
•
•
•
•
•
•
½ inch
½ inch
½ inch
½ inch
¾ inch
¾ inch
¾ inch
¾ inch
¾ inch
¾ inch
½ “ ID C-flex® tubing, 4’ with clamp, female MPX connector, plugged
NA
NA
NA
NA
NA
•
•
•
•
•
Sample Line: 1/8” ID sample line with clamp, and luer lock connection
NA
NA
NA
NA
NA
•
•
•
•
•
Probe Port: Female Kleenpack® Connector port for probe connection
NA
NA
NA
NA
NA
•
•
•
•
•
F
Female Kleenpack® Connector port for probe connection
NA
NA
NA
NA
NA
•
•
•
•
•
G
Thermowell: for non-invasive temperature sensing
NA
NA
NA
NA
NA
•
•
•
•
•
H
Sample Line: 1/8” ID sample line with clamp, and luer lock connection
•
•
•
•
•
•
•
•
•
•
I
Harvest/Drain: C-flex® tubing, 6’ with clamp, plugged (ID indicated)
½ inch
½ inch
½ inch
½ inch
¾ inch
½ inch
½ inch
½ inch
½ inch
¾ inch
XDM QUAD OPTIONS & ACCESSORIES
The following options are available for all XDM Quad Mixing Systems:
u Dual pH/Conductivity Monitoring System
u pH probe
u Conductivity probe
u RTD probe
u Probe sheath assemblies
u Level indication (floor scale or load cells for stainless steel units)
u Temperature Control Unit for heating and cooling of jacketed stainless steel systems
NOTE: All probes and instrumentation are GMP compliant.
www.xcellerex.com • 1-866-Xcellerex
XDM Quad Mixer System Details
uMotor controller (fully wash down rated)
vConvenient buffer tube holders (4)
wAC motor and magnetic drive (fully wash down
rated)
x
u
v
xHandles for ease of mobility
y
yNotches for supporting bag tubing (polypro. units)
zProbe port window and support bar for
(A) pH/Conductivity, (B) inline sampling, and
(C) temperature.
A
z
B
C
w
Detail of probe port window and support bar for inline sampling
and sensing, such as pH, conductivity and temperature.
{
}
{ Removable lid with integrated support for powder
addition port and hopper
| Hopper and 3-inch triclamp for easy powder
addition
} Removable door for easy bag installation and
removal (500L and 1000L only)
~ Mixer bottom is slanted on two planes toward
drain for minimal holdup volume; Magnetic
impeller drive is easily accessible
|
~
www.xcellerex.com • 1-866-Xcellerex
Applications and Performance Data
6g/L NaCL, XDM500
1% NaCL in Corn Syrup, XDM200
11.5
100%
80%
% Dissolved
Conductivity (mS/cm)
11.0
10.5
10.0
60%
75% Corn Syrup, 274 cp
40%
85% Corn Syrup, 561 cp
20%
9.5
90% Corn Syrup, 1000 cp
0%
9.0
0
60
120
180
240
300
0
20
40
Time (seconds)
The XDM Quad demonstrates rapid mixing of common salt solutions.
SODIUM TREND
100
L-Gln (mmol/L)
Glucose (g/L)
Component Concentration
9
8
7
6
5
4
3
2
1
Component Concentration [mmol/L]
Glucose & L-Gln Trends
10
0
60
POTASSIUM TREND
120
180
240
Mix Time (Seconds)
XDM500
DMEM/F-12 Medium Mixing Study
Potassium Trend
100
XDM500
DMEM/F-12 Medium Mixing Study
Sodium Trend
90
Na+ (mmol/L)
80
70
60
50
40
30
20
10
0
300
0
60
120
180
240
300
MixXDM500
Time (Seconds)
DMEM/F-12 Medium Mixing Study
Osmo Trend
Osmolarity Trend
400
10
9
K+ (mmol/L)
Osmo (mOsm/kg)
350
8
300
7
[mOsm/kg]
Component Concentration [mmol/L]
80
The XDM Quad demonstrates effective mixing even at high viscosities
XDM500
DMEM/F-12 Medium, XDM500
DMEM/F-12 Medium Mixing Study
Glucose & L-Gln Trends
0
60
Minutes
6
5
4
250
200
150
3
100
2
50
1
0
0
0
60
120
180
240
300
0
60
Mix Time (Seconds)
120
180
240
300
Mix Time (Seconds)
The XDM Quad demonstrates effective mixing of common cell culture media.
VIDEO demonstration
Base & Acid Addition /
Phenolphthalein Dye Test, XDM500
u
XDM Quad
Applications
A video demonstration of this
mixing test is available at www.xcellerex.com/mixerdemo
www.xcellerex.com • 1-866-Xcellerex
u Buffer and Media Prep
u pH adjustments
u Resuspension
u Chromatography pooling
u Viral inactivation
u UF/DF
u Formulation
u Product Mixing
Ordering Information
XDM Quad System Ordering Codes*
Product Code
Size
Type
XDM-50
50L
Standard Polypropylene
XDM-100
100L
Standard Polypropylene
XDM-200
200L
Standard Polypropylene
XDM-500
500L
Standard Polypropylene
XDM-50-S
50L
Stainless Steel
XDM-100-S
100L
Stainless Steel
XDM-200-S
200L
Stainless Steel
XDM-500-S
500L
Stainless Steel
XDM-1000-S
1,000L
Stainless Steel
XDM-50-S-LC
50L
Stainless Steel with Load Cells
XDM-100-S-LC
100L
Stainless Steel with Load Cells
XDM-200-S-LC
200L
Stainless Steel with Load Cells
XDM-500-S-LC
500L
Stainless Steel with Load Cells
XDM-1000-S-LC
1,000L
Stainless Steel with Load Cells
XDM-50-T
50L
Jacketed Stainless Steel
XDM-100-T
100L
XDM-200-T
XDM-500-T
XDM Quad Bag Assembly Ordering Codes
Product Code
Size
Type
888-0141
50L
Basic
888-0351
50L
Plus
888-0164
100L
Basic
888-0154
100L
Plus
888-0165
200L
Basic
888-0155
200L
Plus
888-0166
500L
Basic
888-0156
500L
Plus
888-0167
1,000L
Basic
Jacketed Stainless Steel
888-0157
1,000L
Plus
200L
Jacketed Stainless Steel
Ask about our made-to-order bags for UF/DF.
500L
Jacketed Stainless Steel
XDM-1000-T
1,000L
Jacketed Stainless Steel
XDM-50-T-LC
50L
Jacketed Stainless Steel with Load Cells
XDM-100-T-LC
100L
Jacketed Stainless Steel with Load Cells
XDM-200-T-LC
200L
Jacketed Stainless Steel with Load Cells
XDM-500-T-LC
500L
Jacketed Stainless Steel with Load Cells
XDM-1000-T-LC
1,000L
Jacketed Stainless Steel with Load Cells
* Various electrical requirements can be accommodated. Please specify at time of order.
To order XDM Quad systems,
bag assemblies or components,
please call
1.866.XCELLEREX
(1.866.923.5537)
Accessory Ordering Codes
Product Code
Description
888-0138
Probe Sheath Assemblies
XDM-Q-HH
Hopper (includes fitting for fastening to 3”
tri-clamp port)
XDM-Q-PB
pH Probe
XDM-Q-CB
Conductivity Probe
XDM-MTR-P-C
pH/Conductivity Monitoring System
XDM-Q-RTD
RTD for Temperature Measurement
1.508.480.9235
For information on Xcellerex’s other innovative single-use technology, including XDR single-use
bioreactors and the FlexFactory biomanufacturing platform, please visit www.Xcellerex.com
TM
Xcellerex, Inc.
170 Locke Drive Marlborough, MA 01752 USA
Toll Free: 1-866-Xcellerex
Tel: 508-480-9235
info@xcellerex.com
www.xcellerex.com
rev. xdmQ-010711