SIGMA-ALDRICH
sigma-aldrich.com
SAFETY DATA SHEET
Version 5.3
Revision Date 07/09/2014
Print Date 07/09/2014
1. PRODUCT AND COMPANY IDENTIFICATION
1.1
1.2
Product identifiers
Product name
:
Isobutyl alcohol
Product Number
Brand
Index-No.
:
:
:
W217905
Aldrich
603-108-00-1
CAS-No.
:
78-83-1
Relevant identified uses of the substance or mixture and uses advised against
Identified uses
1.3
1.4
:
Laboratory chemicals, Manufacture of substances
Details of the supplier of the safety data sheet
Company
:
Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Telephone
Fax
:
:
+1 800-325-5832
+1 800-325-5052
Emergency telephone number
Emergency Phone #
:
(314) 776-6555
2. HAZARDS IDENTIFICATION
2.1
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 3), H226
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
Specific target organ toxicity - single exposure (Category 3), Respiratory system, Central nervous system, H335, H336
Acute aquatic toxicity (Category 2), H401
Chronic aquatic toxicity (Category 2), H411
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2
GHS Label elements, including precautionary statements
Pictogram
Signal word
Danger
Hazard statement(s)
H226
H315
H318
H335
H336
H411
Flammable liquid and vapour.
Causes skin irritation.
Causes serious eye damage.
May cause respiratory irritation.
May cause drowsiness or dizziness.
Toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P210
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
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P233
P240
P241
P242
P243
P261
P264
P271
P273
P280
Keep container tightly closed.
Ground/bond container and receiving equipment.
Use explosion-proof electrical/ ventilating/ lighting/ equipment.
Use only non-sparking tools.
Take precautionary measures against static discharge.
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
Wash skin thoroughly after handling.
Use only outdoors or in a well-ventilated area.
Avoid release to the environment.
Wear protective gloves/ protective clothing/ eye protection/ face
protection.
IF ON SKIN (or hair): Remove/ Take off immediately all contaminated
clothing. Rinse skin with water/ shower.
IF INHALED: Remove victim to fresh air and keep at rest in a position
comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/ physician.
Specific treatment (see supplemental first aid instructions on this label).
If skin irritation occurs: Get medical advice/ attention.
Take off contaminated clothing and wash before reuse.
In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for
extinction.
Collect spillage.
Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.
Dispose of contents/ container to an approved waste disposal plant.
P303 + P361 + P353
P304 + P340
P305 + P351 + P338
P310
P321
P332 + P313
P362
P370 + P378
P391
P403 + P233
P403 + P235
P405
P501
2.3
Hazards not otherwise classified (HNOC) or not covered by GHS - none
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1
Substances
Synonyms
:
Isobutanol
2-Methyl-1-propanol
Isobutyl alcohol
Formula
Molecular Weight
CAS-No.
EC-No.
Index-No.
:
:
:
:
:
C4H10O
74.12 g/mol
78-83-1
201-148-0
603-108-00-1
Component
Classification
Concentration
iso-Butanol
Flam. Liq. 3; Skin Irrit. 2; Eye
Dam. 1; STOT SE 3; Aquatic
Acute 2; Aquatic Chronic 2;
H226, H315, H318, H335,
H336, H411
For the full text of the H-Statements mentioned in this Section, see Section 16.
-
4. FIRST AID MEASURES
4.1
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
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If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.
4.2
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3
Indication of any immediate medical attention and special treatment needed
no data available
5. FIREFIGHTING MEASURES
5.1
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2
Special hazards arising from the substance or mixture
Carbon oxides
5.3
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4
Further information
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES
6.1
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all
sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive
concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
6.3
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations (see section 13).
6.4
Reference to other sections
For disposal see section 13.
7. HANDLING AND STORAGE
7.1
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
For precautions see section 2.2.
7.2
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
resealed and kept upright to prevent leakage.
7.3
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
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8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1
Control parameters
Components with workplace control parameters
Component
CAS-No.
Value
Control
parameters
iso-Butanol
78-83-1
TWA
50 ppm
Remarks
Basis
USA. ACGIH Threshold Limit Values
(TLV)
Skin & eye irritation
TWA
50 ppm
150 mg/m3
TWA
100 ppm
300 mg/m3
USA. OSHA - TABLE Z-1 Limits for
Air Contaminants - 1910.1000
USA. Occupational Exposure Limits
(OSHA) - Table Z-1 Limits for Air
Contaminants
The value in mg/m3 is approximate.
TWA
50 ppm
USA. NIOSH Recommended
150 mg/m3
Exposure Limits
8.2
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method:
EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the
supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an
industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It
should not be construed as offering an approval for any specific use scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of
protective equipment must be selected according to the concentration and amount of the dangerous substance
at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
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Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1
9.2
Information on basic physical and chemical properties
a)
Appearance
Form: liquid
b)
Odour
no data available
c)
Odour Threshold
no data available
d)
pH
no data available
e)
Melting point/freezing
point
Melting point/range: -108 °C (-162 °F) - lit.
f)
Initial boiling point and
boiling range
108 °C (226 °F) - lit.
g)
Flash point
28 °C (82 °F) - closed cup
h)
Evapouration rate
0.6
i)
Flammability (solid, gas) no data available
j)
Upper/lower
flammability or
explosive limits
Upper explosion limit: 10.6 %(V)
Lower explosion limit: 1.7 %(V)
k)
Vapour pressure
8 hPa (6 mmHg) at 20 °C (68 °F)
10 hPa (8 mmHg) at 22 °C (72 °F)
l)
Vapour density
2.55
m) Relative density
0.803 g/cm3 at 25 °C (77 °F)
n)
Water solubility
no data available
o)
Partition coefficient: noctanol/water
no data available
p)
Auto-ignition
temperature
427 °C (801 °F)
q)
Decomposition
temperature
no data available
r)
Viscosity
4.00 mm2/s at 20 °C (68 °F) -
s)
Explosive properties
no data available
t)
Oxidizing properties
no data available
Other safety information
Relative vapour density
2.55
10. STABILITY AND REACTIVITY
10.1
Reactivity
no data available
10.2
Chemical stability
Stable
Stable under recommended storage conditions.
10.3
Possibility of hazardous reactions
Vapours may form explosive mixture with air.
10.4
Conditions to avoid
Heat, flames and sparks.
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10.5
Incompatible materials
Strong oxidizing agents, Acid chlorides, Acid anhydridesStrong oxidizing agents, Acid chlorides, Acid anhydrides
10.6
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5
11. TOXICOLOGICAL INFORMATION
11.1
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 2,460 mg/kg
LD50 Oral - rat - 2,500 - 6,400 mg/kg
LC50 Inhalation - rat - 4 h - 8000 ppm
LD50 Dermal - rabbit - 3,400 mg/kg
LD50 Dermal - rabbit - 4,240 mg/kg
LD50 Intraperitoneal - mouse - 544 mg/kg
LD50 Intravenous - mouse - 417 mg/kg
LD50 Intraperitoneal - rabbit - 323 mg/kg
LD50 Intraperitoneal - guinea pig - 1,201 mg/kg
LD50 Intraperitoneal - Hamster - 1,401 mg/kg
Skin corrosion/irritation
Skin - guinea pig
Result: Mild skin irritation
Serious eye damage/eye irritation
Eyes - rabbit
Remarks: Moderate eye irritation
Eyes - rabbit
Result: Moderate eye irritation
Respiratory or skin sensitisation
Dermatitis
Germ cell mutagenicity
no data available
Carcinogenicity
Carcinogenicity - rat - Oral
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages: Other: Tumors. Leukaemia
Carcinogenicity - rat - Subcutaneous
Tumorigenic:Carcinogenic by RTECS criteria. Gastrointestinal:Tumors. Liver:Tumors.
IARC:
No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
ACGIH:
No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP:
No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA:
No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
no data available
no data available
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Specific target organ toxicity - single exposure
May cause respiratory irritation.
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: NP9625000
Cough, Shortness of breath, Headache, Nausea, Vomiting, Central nervous system depression, To the best of our
knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Stomach - Irregularities - Based on Human Evidence
Stomach - Irregularities - Based on Human Evidence
12. ECOLOGICAL INFORMATION
12.1
Toxicity
Toxicity to fish
LC50 - Pimephales promelas (fathead minnow) - 1.220 mg/l - 96 h
12.2
Persistence and degradability
no data available
12.3
Bioaccumulative potential
no data available
12.4
Mobility in soil
no data available
12.5
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6
Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Toxic to aquatic life.
no data available
13. DISPOSAL CONSIDERATIONS
13.1
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a
licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
UN number: 1212
Class: 3
Proper shipping name: Isobutanol
Reportable Quantity (RQ): 5000 lbs
Marine pollutant: No
Poison Inhalation Hazard: No
IMDG
UN number: 1212
Class: 3
Proper shipping name: ISOBUTANOL
Marine pollutant: No
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Packing group: III
Packing group: III
EMS-No: F-E, S-D
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IATA
UN number: 1212
Class: 3
Proper shipping name: Isobutanol
Packing group: III
15. REGULATORY INFORMATION
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
iso-Butanol
CAS-No.
78-83-1
Revision Date
1993-04-24
CAS-No.
78-83-1
Revision Date
1993-04-24
CAS-No.
78-83-1
Revision Date
1993-04-24
Pennsylvania Right To Know Components
iso-Butanol
New Jersey Right To Know Components
iso-Butanol
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other
reproductive harm.
16. OTHER INFORMATION
Full text of H-Statements referred to under sections 2 and 3.
Aquatic Acute
Aquatic Chronic
Eye Dam.
Flam. Liq.
H226
H315
H318
H335
H336
H401
H411
Skin Irrit.
Acute aquatic toxicity
Chronic aquatic toxicity
Serious eye damage
Flammable liquids
Flammable liquid and vapour.
Causes skin irritation.
Causes serious eye damage.
May cause respiratory irritation.
May cause drowsiness or dizziness.
Toxic to aquatic life.
Toxic to aquatic life with long lasting effects.
Skin irritation
HMIS Rating
Health hazard:
Chronic Health Hazard:
Flammability:
Physical Hazard
2
*
3
0
NFPA Rating
Health hazard:
Fire Hazard:
Reactivity Hazard:
2
3
0
Further information
Copyright 2014 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
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product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling
or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing
slip for additional terms and conditions of sale.
Preparation Information
Sigma-Aldrich Corporation
Product Safety – Americas Region
1-800-521-8956
Version: 5.3
Aldrich - W217905
Revision Date: 07/09/2014
Print Date: 07/09/2014
Page 9 of 9