April 26, 2012 pinna to ear drum filled with air ear drum to oval window(cochlea) filed with air cochlea (oval window to auditory nerves) filled with fluid channel sound wave (variations in air pressure) to ear drum vibrate in resonance with sound wave to drive the ossicles Equalize pressure on both sides of eardrum d) hammer anvil and stirrup – malleus, incus, and stapes vibrate the oval window causing fluid in cochlea to vibrate e) vibration of cochlear fluid causes hairs (cilia) to vibrate which creates electrical impulse different hairs resonate with different frequencies transform vibrations of fluid into electrical impulses f) send electrical impulses to brain to allow sound to be interpreted April 26, 2012 Longitudinal, mechanical wave – variations in pressure (eg. Air) Produced by vibration of object producing sound Frequency of sound is frequency of object’s vibration – forced oscillation – driving frequency force per unit area \ mechanical advantage that turns a small force at tympanic membrane into a larger force at oval window (1.5:1) – force multiplier small area of eardrum and smaller area of oval window (20:1) Lever action of ossicles increases force which then acts on a smaller area Sound pressure is amplified by inner ear PO > P T since F increases and A decreases (30:1) Transmission not reflection Mechanism for pressure transformation between media of different densities (air and fluid) Without it, most sound would be reflected from cochlear fluid rather transmitted – when densities are very different at a boundary (impedance matching) April 26, 2012 response of the ear to intensity response of ear to intensity is logarithmic – doubling intensity does not double loudness – relationship is logarithmic Intensity is well-defined Loudness is not well-defined Same intensity does not seem as loud at different frequencies – perceived loudness varies from person to person and frequency to frequency April 26, 2012 ten times the common logarithm of the ratio of the sound intensity of a sound to the sound intensity at the threshold of hearing April 26, 2012 10 dB for every factor of 10 in intensity, an increase of 10 dB logarithmic response – approx. doubles the perceived loudness threshold of pain = approx 120 dB I/I0 = 1012 = twelve orders of magnitude more intense April 26, 2012 Reduced frequency range – greater loss at higher frequencies – increased intensity needed at all frequencies April 26, 2012 electrons boiled off a filament due to heating electrons accelerated through a high potential difference strike a metal target – tungsten inner shell target electrons jump to high energy level and emit x-ray photons when relax X-rays pass through person and fall on a photographic film which darkens when x-rays hit it Bone absorbs more of x-rays than soft tissue so tissue is darker and bone is lighter fluorescent screens surround photographic plate to intensify image Scattered x-rays are absorbed by lead plates before photographic film – reduces blurring – increases sharpness April 26, 2012 lessening of radiation in intensity spreading out of beam – we only look at parallel beams being absorbed by a material (eg. Bone) thickness of material needed for a beam of X-rays to be attenuated (reduced in intensity) by 50% ratio of the natural log of 2 to the half-value thickness April 26, 2012 attenuation coefficient greater for bone than for muscle/tissue so intensity of X-ray less for section of film where bone is =lighter image for bone good contrast to darker image for muscle April 26, 2012 April 26, 2012 April 26, 2012 an attempt to balance the risk of exposure to ionizing radiation with the benefits of its use in diagnosis and treatment of illness April 26, 2012 a quartz crystal that changes shape when a potential difference is applied across it apply an AC voltage to generate a vibration at desired frequency received sound wave causes it to vibrate and generate an AC voltage that can be measured April 26, 2012 size of smallest object that can be imaged. Ultrasound is a wave so diffraction effects must be minimized. Use smallest wavelength possible absorption of signal. Attenuation increases as frequency increases. High frequency ultrasound will be absorbed and not reflected back to receiver. High frequency can’t scan organs deep in body – poor depth penetration between two extremes – choose frequency so body part being imaged is about 200 wavelengths from probe product of the density of a substance and the speed of sound in that substance April 26, 2012 the greater the difference between the two media, the more reflection occurs Prevents reflections of ultrasound at skin surface because most reflection occurs at air/skin boundary amplitude-modulated scan – one-dimensional – not usually used graph of signal strength versus time April 26, 2012 brightness-modulated scan – two-dimensional – most frequent – uses the signal strength to affect the brightness of a dot on the screen many B-scans are combined to give an image of the internal organs/baby nuclear magnetic resonance magnetic resonance imaging low-energy radiation in radio region of EM spectrum magnetic fields imaging blood flow and soft tissue in the body Preferred for the brain and central nervous system Detecting tumors, strokes, infections in brain, spine, joints April 26, 2012 April 26, 2012 April 26, 2012 radiation used for imaging radiation used for treatment techniques for the measurement of amounts of ionizing radiation ratio of total charge of air ionized by radiation to mass of air attempt to measure total amount of ionization produced by radiation – limited application since doesn’t measure ability of body tissue to absorb radiation total energy absorbed per unit mass of tissue difficult to measure directly – attempts to measure amount of radiation tissue absorbs type, intensity, time roentgen April 26, 2012 for the same absorbed dose, this measures the relative effectiveness of different radiations in destroying cells other radiations measured against X-rays– alpha particles are 10 times more damaging per dose than X rays product of quality factor and absorbed dose attempts to measure the radiation damage that actually occurs in tissues Effect depends on amount of ionization Alpha causes more ionization per unit length of its track Takes into account density of ionization/deposition of energy April 26, 2012 quality factor April 26, 2012 time taken for half the number of ingested radioactive nuclei in the body to be removed by natural bodily (chemical) processes time taken for the number of radioactive nuclei present in the body to halve April 26, 2012