Comparison of VA National Formulary and Formularies of the Highest Enrollment Plans in Medicare Part D and the Federal Employee Health Benefit Program Prepared for: PhRMA Submitted by: The Lewin Group, Inc. December 10, 2008 Comparison of VA National Formulary and Formularies of the Highest Enrollment Plans in Medicare Part D and the Federal Employee Health Benefit Program Prepared for: PhRMA Submitted by: The Lewin Group, Inc. December 10, 2008 The Pharmaceutical Research and Manufacturers of America asked The Lewin Group to compare the formulary status of drugs commonly used by the Medicare population on the Veterans Affairs National Formulary (VA formulary), the two highest enrollment Medicare Part D plans, and the plan with highest enrollment in the Federal Employee Health Benefit Program (FEHBP). Lewin first completed this analysis in January 2007 using the 2007 versions of the VA formulary, Medicare Part D formularies, and FEHBP formulary. This report provides an update to the 2007 analysis. In addition, we analyzed the tier distribution of the drugs covered on the Part D formularies. Lewin identified the drugs most commonly used by the Medicare population by querying Verispan’s Vector One National Audit (VONA) data to compile the 300 drugs with the highest script volumes for the 65 and older population.1 Nineteen of the top 300 drugs are not covered by the Part D program due to statutory or regulatory requirements.2 We conducted the analysis using the remaining 281 Part D covered drugs. Key Findings Overall, coverage of the top Part D covered drugs by the VA formulary, FEHBP formulary, and the formularies of the two highest enrollment Medicare Part D plans remains largely unchanged since the 2007 analysis. The FEHBP and Medicare Part D formularies that we analyzed all provide a greater breadth of drug coverage than the VA formulary. Additionally, both of the Part D formularies placed close to 90 percent of the top 281 Part D covered drugs on either tier one or tier two. Exhibit 1 illustrates the number and percent of scripts covered by the VA, FEHBP, and the two Medicare Part D formularies for all of the general drug categories that are captured by the top Part D covered drugs. Exhibit 2 illustrates the formulary status for each of the top 300 drugs. ⇒ Of the 281 Part D covered drugs, 183 (65%) are included in the VA formulary, compared to 273 (97%) in the FEHBP formulary, 278 (99%) in the highest enrollment Part D plan formulary, and 280 (100%) in the second highest enrollment Part D plan formulary. Of the 116 brand drugs among the 281 Part D covered drugs, 51 (44%) are covered by the VA formulary, compared to 115 (99%) covered by the FEHBP formulary, 114 (98%) covered by the highest enrollment Part D plan formulary, and 116 (100%) covered by the second highest enrollment Part D plan formulary. ⇒ The two highest enrollment Part D plans predominantly place the top 281 Part D covered drugs on tiers one or two. Of the 278 drugs covered by the highest enrollment Part D plan formulary, 242 (87%) are on tiers one or two. Of the 280 drugs covered by the second highest enrollment Part D plan formulary, 248 (89%) are on tiers one or two. 1 The script volume for each drug is from the time period of January 2008 through July 2008. 2 The following drugs excluded from Part D coverage: Alprazolam, Aspirin (enteric-coat), Benzonatate, Cheratussin AC, Cialis, Clonazepam, Cyanocobalamin, Diazepam, Docusate Sodium, Ferrous Sulfate, Folic Acid, Levitra, Lorazepam, Phenobarbital, Promethazine/Codeine, Temazepam, Tussionex, Viagra, Vitamin D. The list of Part D excluded drugs was obtained from: www.cms.hhs.gov/PrescriptionDrugCovContra/Downloads/R2PDB.pdf. 1 471062 ⇒ Of the 569 million scripts analyzed, 72% of the total and 41% of the brand scripts are covered by the VA formulary. In contrast, 99% of all scripts and 100% of brand scripts are covered by the FEHBP plan. The highest enrollment Part D plan covers 99% of all scripts and 99% of brand scripts and the second highest enrollment Part D plan covers 100% of all scripts and 100% of brand scripts. ⇒ VA formulary coverage varies widely among the drug categories due to the partially closed nature of the formulary; for example, while 76% of all scripts are covered in the largest category (cardiovascular), fewer than half of scripts for ear, nose, and throat and urologic disorders are covered. Methodology We downloaded the VA’s National Drug File from the VA pharmacy website3 and checked each of the 281 Part D covered drugs against those covered by the VA formulary. Since the VA formulary is organized by generic entity and only includes the names of brand name drugs when they cannot be substituted due to narrow therapeutic index, all matches were based on the generic name of the drug. For example, if the brand name of a drug appears on the list of top drugs and that drug’s generic name is listed on the VA formulary, the brand drug is counted as being on the VA formulary. In some cases, the VA formulary covers only certain strengths or forms of a particular drug (e.g., IV version is covered but the tablets are not covered). In those cases, we looked at the breakdown of script volume by dosage and form for that drug within the VONA data in order to determine how many scripts are covered on the VA formulary and how many are excluded. For the purposes of Exhibit 1, we only counted scripts for a particular drug when those specific formulations (e.g., capsules, extended release version) were covered. In order to determine formulary coverage for Exhibit 2, we used the percent of the VONA scripts for that drug that were actually covered as a proxy for formulary coverage. If more than 90% of the script volume for a particular drug was covered by the VA formulary, the entire drug was considered as being covered on the VA formulary. If less than 5% of the script volume for a particular drug was covered by the VA formulary, the entire drug was labeled as being excluded from the VA formulary. If between 5% and 90% of the script volume for a particular drug was covered by the VA formulary, the drug was labeled as having “some forms” on the VA formulary. Using this methodology, only three drugs4 were labeled as excluded because the VA formulary covered less than 5% of each drug’s script volume. Drugs meeting the “some forms” or “included” criterion were counted as being covered on the formulary. The FEHBP national plan with highest enrollment is the Blue Cross Blue Shield FEP Basic plan. The FEP basic formulary was obtained from the BCBS Federal Employee Program website.5 Similar to the VA formulary, the FEP Basic formulary does not list all the brand name drugs covered, but instead is organized by generic entity. Therefore, we matched drugs on the FEP 3 http://www.pbm.va.gov/NationalFormulary.aspx 4 Protonix, famotidine, and labetalol 5 http://www.caremark.com/portal/asset/feprx_807.pdf 2 471062 Basic formulary to each of the 281 Part D covered drugs based on the generic form of the drug. The FEP Basic formulary generally covers or excludes all forms of a drug, so if a drug was covered on the formulary, we counted all of the scripts for that drug as being covered. According to CMS data, the two highest enrollment Medicare Part D plans based on October 2008 enrollment are the United AARP MedicareRx Preferred Plan and the Humana Standard Plan. The United AARP MedicareRx Preferred formulary and Humana Standard formulary were obtained from each plan’s respective website.6 Unlike the VA and FEHBP formularies, the format of the Part D formularies allowed us to consider whether the brand form, generic form, or both are on formulary. Therefore, for example, we only counted the brand version as being covered if the specific brand name appeared on the Part D plan formulary. If only the generic name appeared on the plan’s formulary, the brand version was not counted as being on the Part D plan formulary. Only one drug, Nitroquick, was excluded from the count of Part D covered drugs due to this different method of counting formulary coverage for the Part D plans. The United AARP MedicareRx Preferred Plan does not cover Nitroquick, however it does cover the generic form of the drug, nitroglycerin. Like the FEHBP formulary, the Medicare Part D formularies generally either cover or exclude all forms of a drug. If a drug was on the Part D formulary, we counted all of the scripts for that drug as being covered. Beyond inclusion on the formulary, the tier assignment of a particular drug can impact its accessibility for the beneficiary. Both the United AARP MedicareRx Preferred plan and the Humana Standard plan use a four tier formulary structure. In multi-tier formularies, drugs placed on tiers one or two are considered preferred generic and brand drugs and have lower cost share requirements than drugs on higher tiers. United AARP MedicareRx Preferred members pay tiered copayments for drugs on the first three tiers and 33% coinsurance for drugs on the fourth tier. Humana PDP Standard members pay 25% coinsurance for drugs across all tiers. While the Humana PDP Standard has a single coinsurance structure, the four tier formulary structure is the same as those used for Humana’s PDP Enhanced and Complete plans and reflects which drugs Humana considers preferred brand and generic drugs. We examined the tier placement of the 281 Part D covered drugs for both of the Part D formularies to see what percent of these top drugs were placed on a preferred tier. United AARP formulary from https://www.aarpmedicarerx.com/online_documents/ovation/pdf/pdp/en/2009/ FLPDP3023174_XAPE002.pdf and Humana Standard formulary from http://apps.humana.com/marketing/documents.asp?file=906360 6 3 471062 Exhibit 1: Scripts Covered by the VA, FEHBP, and Two Medicare Part D Formularies, by General Drug Category1 VA National Formulary General Drug Category Cardiovascular Agents (High Blood Pressure, Heart Disease) Gastrointestinal Drugs (Stomach and Intestine Disorders) Antimicrobials and Infectious Diseases (Infection) Pain and Inflammatory Diseases (Arthritis, Gout) Psychiatric Eye Respiratory Drugs (Asthma, Emphysema) Neurological Drugs (Migraine, Parkinson's Disease, Alzheimer's Disease) Hormone Therapy/Menopause Ear, Nose and Throat Hormones (Thyroid, Growth Hormones) Urologic Disorders Anticoagulants and Hematopoietics (Blood Modifiers) Benign Prostatic Hyperplasia Skin (Acne, Skin Infection, Psoriasis) Women's Health Antineoplastics and Immunosuppressants Supplements Total - Part D Covered Drugs Total - Brand Drugs Count of Drugs Total Scripts (in 000s) 83 35 22 22 20 15 15 14 11 10 9 8 7 4 2 2 1 1 281 116 245,167 63,361 31,015 46,952 34,042 11,635 21,166 19,106 19,411 7,977 28,323 6,044 21,861 8,817 1,845 1,282 601 483 569,088 183,136 Scripts Covered (in 000s) 185,117 33,273 27,744 33,023 23,072 6,284 14,967 15,473 13,894 3,471 27,705 1,888 20,753 3,788 0 1,282 0 482 412,217 75,143 % Scripts Covered 76% 53% 89% 70% 68% 54% 71% 81% 72% 44% 98% 31% 95% 43% 0% 100% 0% 100% 72% 41% FEHBP with Highest Enrollment Formulary Scripts % Scripts Covered (in Covered 000s) 243,431 99% 63,361 100% 31,015 100% 46,284 99% 34,042 100% 11,635 100% 21,166 100% 17,562 92% 19,411 100% 7,492 94% 28,323 100% 6,044 100% 21,861 100% 8,817 100% 1,845 100% 1,282 100% 601 100% 483 100% 564,653 99% 182,792 100% Highest Enrollment Medicare Part D PDP Scripts % Scripts Covered (in Covered 000s) 237,780 97% 63,361 100% 31,015 100% 46,952 100% 34,042 100% 11,635 100% 21,166 100% 19,106 100% 19,411 100% 7,977 100% 27,707 98% 5,647 93% 21,861 100% 8,817 100% 1,845 100% 1,282 100% 601 100% 483 100% 560,687 99% 181,436 99% 2nd Highest Enrollment Medicare Part D PDP Scripts % Scripts Covered (in Covered 000s) 245,167 100% 63,361 100% 31,015 100% 46,952 100% 34,042 100% 11,635 100% 20,773 98% 19,106 100% 19,411 100% 7,977 100% 28,323 100% 6,044 100% 21,861 100% 8,817 100% 1,845 100% 1,282 100% 601 100% 483 100% 568,695 100% 183,136 100% Scripts associated with the following Part D excluded drugs are not included in this exhibit: Alprazolam, Aspirin (enteric-coat), Benzonatate, Cheratussin AC, Cialis, Clonazepam, Cyanocobalamin, Diazepam, Docusate Sodium, Ferrous Sulfate, Folic Acid, Levitra, Lorazepam, Phenobarbital, Promethazine/Codeine, Temazepam, Tussionex, Viagra, Vitamin D. The list of Part D excluded drugs was obtained from: http://www.cms.hhs.gov/PrescriptionDrugCovContra/Downloads/R2PDB.pdf. 1 4 471062 Exhibit 2: Top 300 Drugs for the 65+ Population by Script Volume, January – July 20081 (highlighted drugs are statutory exclusions from Part D coverage) 65+ Script Ranking 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 Drug Name Generic/Active Ingredient Lisinopril lisinopril Simvastatin simvastatin Furosemide Oral furosemide Lipitor atorvastatin Hydrocodone/APAP hydrocodone/acetaminophen Levothyroxine levothyroxine Amlodipine Besylate amlodipine besylate Hydrochlorothiazide hydrochlorothiazide Atenolol atenolol Metoprolol Succinate metoprolol succinate Metoprolol Tartrate metoprolol tartrate Plavix clopidogrel Warfarin warfarin Metformin metformin Omeprazole omeprazole 4 alprazolam Alprazolam Nexium esomeprazole Triamterene w/HCTZ triamterene/hydrochlorothiazide Klor-Con potassium chloride Diovan valsartan Prednisone Oral prednisone Synthroid levothyroxine Propoxyphene-N/APAP propoxyphene/acetaminophen Lovastatin lovastatin Potassium Chloride potassium chloride Azithromycin azithromycin 4 lorazepam Lorazepam Alendronate alendronate Flomax tamsulosin Gabapentin gabapentin Zolpidem Tartrate zolpidem tartrate Carvedilol carvedilol Isosorbide Mononitrt isosorbide mononitrate Lisinopril/HCTZ lisinopril/hydrochlorothiazide Ciprofloxacin HCl ciprofloxacin hydrochloride Amoxicillin amoxicillin Sertraline sertraline Vytorin ezetimibe Enalapril enalapril Allopurinol allopurinol Pravastatin pravastatin Advair Diskus fluticasone/salmeterol Tramadol tramadol Prevacid lansoprazole Zetia ezetimibe Crestor rosuvastatin Actos pioglitazone Lexapro escitalopram Aricept donepezil Diovan HCT hydrochlorothiazide/valsartan Actonel risedronate Amlodipine Besylate/Benaamlodipine besylate/benazepril Metformin HCl ER metformin Levaquin levofloxacin Cephalexin cephalexin Celebrex celecoxib Xalatan latanoprost Cozaar losartan Singulair montelukast Citalopram HBR citalopram Glyburide glyburide Ranitidine HCl ranitidine hydrochloride Spiriva tiotropium Oxycodone w/APAP oxycodone/acetaminophen Digoxin digoxin Meloxicam meloxicam Clonidine clonidine Glimepiride glimepiride Paroxetine paroxetine Verapamil SR verapamil Spironolactone spironolactone Amitriptyline amitriptyline Lantus insulin glargine Fexofenadine fexofenadine 4 folic acid Folic Acid 4 clonazepam Clonazepam Tricor fenofibrate Fluoxetine fluoxetine Brand/ Generic G G G B G G G G G G G B G G G G B G B B G B G G G G G G B G G G G G G G G B G G G B G B B B B B B B B G G B G B B B B G G G B G G G G G G G G G B G G G B G Highest 2nd Highest FEHBP with Estimated VA Enrollment Enrollment Scripts Sales Highest Sales National Medicare Medicare For 65+ Ranking Enrollment Ranking Formulary PDP PDP (in 000s) (all U.S.) Formulary Formulary Formulary (65+)2 Status3 Status Tier Status Tier Status 17,591 Y Y 1/2 1/2 49 67 15,687 Y Y 1/2 1/2 13 25 14,456 Y Y 1/2 1/2 109 207 13,908 N Y 1/2 1/2 1 1 13,770 Y Y 1/2 1/2 42 17 13,534 Y Y 1/2 1/2 59 89 12,368 Y Y 1/2 1/2 26 58 11,962 Y Y 1/2 1/2 119 157 11,405 Y Y 1/2 1/2 114 162 11,405 Y Y 1/2 1/2 16 34 9,856 Y Y 1/2 1/2 128 210 9,358 Y Y 1/2 1/2 2 3 8,775 Y Y 1/2 1/2 60 147 7,649 Y Y 1/2 1/2 77 105 7,524 Y Y 1/2 1/2 25 39 139 104 5,682 Y Y N N 5,626 N Y 1/2 1/2 3 2 5,369 Y Y 1/2 1/2 184 267 5,052 Y Y 1/2 1/2 140 260 4,881 Y Y 1/2 1/2 12 29 4,786 Y Y 1/2 1/2 183 208 4,763 Y Y 1/2 1/2 80 93 4,722 N Y 1/2 1/2 151 197 4,678 Y Y 1/2 1/2 65 122 4,632 Y Y 1/2 1/2 135 254 4,612 Y Y 1/2 1/2 61 27 120 139 4,611 Y Y N N 4,569 Y Y 1/2 1/2 41 94 4,550 N Y 1/2 1/2 8 33 4,485 Y Y 1/2 1/2 48 54 4,458 N Y 1/2 1/2 63 64 4,326 Y Y 1/2 1/2 84 158 4,048 Y Y 1/2 1/2 173 378 3,974 Y Y 1/2 1/2 165 191 3,952 Y Y 1/2 1/2 194 217 3,939 Y Y 1/2 1/2 217 106 3,884 Y Y 1/2 1/2 99 74 3,855 N Y 1/2 1/2 9 19 3,679 Y Y 1/2 1/2 169 264 3,650 Y Y 1/2 1/2 260 422 3,596 N Y 1/2 1/2 92 140 3,543 N Y 1/2 1/2 4 4 3,489 Y Y 1/2 1/2 157 152 3,459 N Y 1/2 1/2 7 5 3,445 N Y 1/2 1/2 15 30 3,424 N Y 3/4 1/2 14 21 3,402 N Y 1/2 1/2 5 9 3,375 N Y 1/2 1/2 21 10 3,345 Y Y 1/2 1/2 6 35 3,295 N Y 1/2 1/2 23 32 3,084 Y Y 1/2 1/2 24 62 3,060 Y 1/2 1/2 27 43 N 2,972 Y Y 1/2 1/2 180 218 2,872 N Y 1/2 1/2 19 23 2,854 Y Y 1/2 1/2 215 170 2,832 N Y 3/4 1/2 11 22 2,753 N Y 3/4 1/2 45 111 2,733 Y Y 3/4 3/4 36 68 2,717 Y Y 1/2 1/2 22 6 2,712 Y Y 1/2 1/2 216 176 2,642 Y Y 1/2 1/2 187 323 2,574 Y Y 1/2 1/2 195 236 2,567 Y Y 1/2 1/2 10 36 2,563 some forms Y 1/2 1/2 130 73 2,529 Y Y 1/2 1/2 315 610 2,515 N Y 1/2 1/2 200 253 2,501 Y Y 1/2 1/2 275 377 2,500 N Y 1/2 1/2 229 368 2,457 Y Y 1/2 1/2 141 126 2,447 Y Y 1/2 1/2 145 231 2,379 Y Y 1/2 1/2 185 285 2,351 Y Y 1/2 1/2 377 437 2,343 N Y 1/2 1/2 18 24 2,261 N Y 1/2 1/2 75 55 347 492 2,246 Y Y N N 239 160 2,200 Y Y N N 2,172 N Y 1/2 1/2 30 31 2,157 Y Y 1/2 1/2 221 134 5 471062 65+ Script Ranking Drug Name 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 Albuterol Aerosol Doxazosin Glipizide Trazodone HCl Pantoprazole Premarin Tabs 4 Temazepam Namenda Fluticasone Nasal Benazepril Detrol LA 4 Diazepam Ibuprofen Cyclobenzaprine Lyrica Meclizine HCl Acetaminophen w/Cod Digitek Evista Glipizide ER Benicar Naproxen Levoxyl Potassium Chloride E Cartia XT Terazosin Hyzaar Fosamax Avapro Quinapril Diltiazem CD Ramipril Nifedipine ER Trimethoprim/Sulfa Boniva Combivent Finasteride Methylprednis Tabs Doxycycline Effexor XR Cymbalta Lanoxin Coumadin Tabs Amoxicillin/Pot Clav Mirtazapine ProAir HFA Metoclopramide Triamcinln Acet Top Avodart Seroquel Gemfibrozil 4 Viagra Benicar HCT 4 Vitamin D Nitroglycerin Felodipine ER Glybrid/Metfrmin HCl Protonix Carbidopa/Levodopa Januvia Amiodarone Propranolol HCl Nasonex Fentanyl Transdermal Nitroquick Niaspan Aciphex Lumigan Polyethylene Glycol Alphagan P Toprol XL Avalide 4 Aspirin,Enteric-Coat Albuterol Neb Soln Promethazine Tabs Methotrexate Diclofenac Sodium SR Lidoderm Hydralazine Famotidine Hydroxyzine Altace Generic/Active Ingredient albuterol doxazosin glipizide trazodone hydrochloride pantoprazole estrogens, conjugated temazepam memantine fluticasone benazepril tolterodine diazepam ibuprofen cyclobenzaprine pregabalin meclizine acetaminophen/codiene digoxin raloxifene glipizide olmesartan naproxen levothyroxine potassium chloride diltiazem terazosin hydrochlorothiazide/losartan alendronate irbesartan quinapril diltiazem ramipril nifedipine trimethoprim/sulfamethoxazole ibandronate albuterol/ipratropium finasteride methylprednisolone doxycycline venlafaxine duloxetine digoxin warfarin amoxicillin/potassium clavulanate mirtazapine albuterol metoclopramide triamcinolone acetonide dutasteride quetiapine gemfibrozil sildenafil hydrochlorothiazide/olmesartan vitamin D nitroglycerin felodipine glyburide/metformin pantoprazole carbidopa/levodopa sitagliptin amiodarone propranolol mometasone fentanyl nitroglycerin niacin rabeprazole bimatoprost polyethylene glycol brimonidine metoprolol succinate hydrochlorothiazide/irbesartan aspirin albuterol promethazine methotrexate diclofenac sodium lidocaine hydralazine famotidine hydroxyzine ramipril Brand/ Generic G G G G G B G B G G B G G G B G G B B G B G B G B G B B B G G G G G B B G G G B B B B G G B G G B B G B B G G G G B G B G G B G B B B B G B B B G G G G G B G G G B Highest 2nd Highest FEHBP with Estimated VA Enrollment Enrollment Scripts Sales Highest Sales National Medicare Medicare For 65+ Ranking Enrollment Ranking Formulary PDP PDP (in 000s) (all U.S.) Formulary Formulary Formulary (65+)2 Status3 Status Tier Status Tier Status 2,155 2,133 2,123 2,122 2,101 2,081 2,041 2,038 1,950 1,921 1,921 1,838 1,803 1,786 1,786 1,745 1,742 1,723 1,722 1,721 1,712 1,696 1,688 1,672 1,672 1,655 1,648 1,644 1,639 1,618 1,598 1,596 1,572 1,550 1,550 1,535 1,526 1,505 1,488 1,465 1,451 1,422 1,408 1,407 1,387 1,366 1,366 1,345 1,322 1,321 1,316 1,312 1,290 1,282 1,266 1,251 1,201 1,195 1,186 1,180 1,155 1,153 1,139 1,112 1,083 1,082 1,075 1,074 1,072 1,040 1,030 1,019 1,015 1,012 1,010 1,001 991 975 970 969 966 958 156 285 330 324 33 72 296 20 123 279 29 346 401 312 28 379 322 423 44 205 68 343 257 271 125 264 56 53 62 189 133 91 106 367 52 50 82 426 376 34 38 358 137 142 222 154 395 414 55 17 255 66 83 349 259 127 188 51 163 37 210 319 90 35 529 57 46 79 240 104 164 98 742 269 396 292 310 32 247 410 273 118 120 520 511 296 40 85 432 83 81 419 66 333 243 203 28 609 290 748 96 349 113 321 328 462 216 494 92 125 119 293 249 127 180 324 95 86 181 395 339 8 13 676 278 51 317 109 493 458 135 7 350 47 100 498 514 229 269 80 367 52 444 398 46 42 875 77 38 188 357 223 271 133 1106 226 310 389 348 44 460 567 282 168 Y Y Y Y N Y Y Y N Y N Y Y Y N Y Y Y N N N Y Y Y N Y N Y N N some forms N Y Y N Y Y Y Y Y N Y Y Y Y Y Y Y N Y Y N N N some forms Y N N Y N Y Y N Y Y Y N N N Y Y N Y Y Y Y Y N Y N Y N Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y N Y N Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y N Y Y Y Y Y Y Y Y Y 1/2 1/2 1/2 1/2 1/2 1/2 N 1/2 1/2 1/2 1/2 N 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 3/4 1/2 3/4 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 N 1/2 N 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 N 1/2 3/4 1/2 1/2 1/2 3/4 3/4 N 1/2 3/4 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 N 1/2 1/2 1/2 1/2 N 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 3/4 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 N 1/2 N 1/2 1/2 1/2 3/4 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 3/4 1/2 1/2 1/2 3/4 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 6 471062 65+ Script Ranking Drug Name 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 Fluconazole Cosopt Colchicine Fosamax Plus D Ambien CR Clindamycin Systemic 4 Ferrous Sulfate Avandia Bisoprolol/HCTZ Clotrimazl/Betamthsn Glipizide XL Ntrofrntin Mnohy Mcr Oxybutynin Chloride Diltiazem SR Lotrel Sotalol Carisoprodol Risperdal Lunesta Nabumetone Sulfamethoxazole/Tri Atenolol Chlorthal Vigamox Vesicare Aggrenox Fosinopril Sodium Caduet 4 Benzonatate Avelox Requip Nitrofurantoin Mcroc Torsemide Labetalol Metronidazole Tabs Phenytoin Sodium Ext Mirapex 4 Promethazine/Codeine Bumetanide Non-Inj Tramadol HCl/APAP Atacand Timolol Maleate Oph Clobetasol Levothroid Micardis Cilostazol Oxycodone Metolazone Estradiol Oral Thyroid, Armour Travatan 4 Cheratussin AC Oxybutynin Chl ER Coreg CR Buspirone HCl Arimidex Captopril Zymar Dicyclomine HCl 4 Cialis Humulin 70/30 Humulin N Timolol Maleate GFS Fluocinonide Hydroxychloroquine Zyprexa Penicillin VK Lovaza Flovent HFA Humalog Indapamide Mupirocin 4 Cyanocobalamin Nifedical XL Restasis NovoLog Nifedipine Prednisolne Acet Oph Micardis HCT Nortriptyline OxyContin Enablex Chlorhexidine Glucon Generic/Active Ingredient fluconazole dorzolamide/timolol colchicine alendronate/cholecalciferol zolpidem clindamycin ferrous sulfate rosiglitazone bisoprolol/hydrochlorothiazide clotrimazole/betamethasone glipizide nitrofurantoin oxybutynin chloride diltiazem amlodipine/benazepril sotalol carisoprodol risperidone eszopiclone nabumetone sulfamethoxazole/trimethoprim atenolol/chlorthalidone moxifloxacin solifenacin aspirin/dipyridamole fosinopril amlodipine/atorvastatin benzonatate moxifloxacin ropinirole nitrofurantoin torsemide labetolol metronidazole phenytoin pramipexole promethazine/codeine bumetanide tramadol hydrochloride/acetaminophen candesartan timolol clobetasol levothyroxine telmisartan cilostazol oxycodone metolazone estradiol thyroid travoprost guaifenesin oxybutynin chloride carvedilol buspirone anastrozole captopril gatifloxacin dicyclomine tadalafil insulin human insulin human timolol fluocinonide hydroxychloroquine olanzipine penicillin omega 3 acid fluticasone insulin lispro indapamide mupirocin cyanocobalamin nifedipine cyclosporine insulin aspart nifedipine prednisolone/sulfacetamide telmisartan nortriptyline oxycodone darifenacin chlorhexidine gluconate Brand/ Generic G B G B B G G B G G G G G G B G G B B G G G B B B G B G B B G G G G G B G G G B G G B B G G G G B B B G B G B G B G B B B G G G B G B B B G G G G B B G G B G B B G 2nd Highest Highest FEHBP with Estimated VA Enrollment Enrollment Highest Scripts Sales Sales National Medicare Medicare Enrollment For 65+ Ranking Ranking Formulary PDP PDP Formulary (in 000s) (all U.S.) Formulary Formulary (65+)2 Status3 Status Tier Status Tier Status 957 Y Y 1/2 1/2 455 318 946 Y Y 1/2 1/2 71 183 943 Y Y 1/2 1/2 490 736 924 N Y 1/2 1/2 103 186 908 N Y 1/2 3/4 78 50 897 Y Y 1/2 1/2 274 237 638 853 893 Y N N N 886 Y Y 1/2 1/2 54 88 881 N Y 1/2 1/2 434 540 870 N Y 1/2 1/2 305 379 844 N Y 1/2 1/2 320 500 835 Y Y 3/4 1/2 352 406 825 Y Y 1/2 1/2 494 770 798 Y Y 1/2 1/2 301 531 790 N Y 1/2 1/2 94 123 782 Y Y 1/2 1/2 278 530 772 N N 1/2 1/2 393 209 769 Y Y 1/2 1/2 43 16 763 N Y 1/2 3/4 85 60 757 N Y 1/2 1/2 231 257 751 Y Y 1/2 1/2 566 564 749 Y Y 1/2 1/2 541 724 737 Y Y 1/2 3/4 168 190 736 N Y 3/4 1/2 93 165 734 Y Y 1/2 1/2 73 184 731 Y Y 1/2 1/2 340 536 724 N Y 3/4 3/4 74 121 355 384 724 N Y N N 721 Y Y 1/2 3/4 117 103 712 N Y 1/2 1/2 107 143 711 Y Y 3/4 1/2 308 455 710 N Y 1/2 1/2 303 542 705 N N 1/2 1/2 333 483 705 Y Y 1/2 1/2 592 555 702 Y Y 1/2 1/2 286 355 688 Y Y 1/2 1/2 97 148 503 468 680 N Y N N 674 Y Y 1/2 1/2 453 785 668 N N 1/2 1/2 243 298 665 N Y 3/4 3/4 158 262 654 Y Y 1/2 1/2 555 972 647 Y Y 1/2 1/2 288 346 645 Y Y 1/2 1/2 559 830 642 N Y 3/4 3/4 179 263 642 N Y 1/2 1/2 262 509 627 some forms Y 1/2 1/2 201 115 625 Y Y 1/2 1/2 335 589 622 Y Y 1/2 1/2 610 566 617 N Y N 1/2 496 572 611 Y Y 1/2 1/2 148 329 624 644 610 Y N N N 610 N Y 1/2 1/2 147 252 608 N Y 3/4 3/4 115 169 608 Y Y 1/2 1/2 364 338 601 N Y 1/2 1/2 47 82 595 Y N 1/2 1/2 635 1030 591 N Y 1/2 3/4 202 371 591 Y Y 3/4 1/2 584 713 146 91 572 N N N N 570 Y Y 1/2 1/2 162 274 559 Y Y 1/2 1/2 190 272 558 Y Y 1/2 1/2 354 661 551 Y Y 1/2 1/2 484 623 551 Y Y 1/2 1/2 406 456 545 Y Y 1/2 1/2 31 18 542 Y Y 1/2 1/2 601 441 542 N Y 3/4 3/4 124 129 539 N Y 1/2 1/2 131 87 535 N Y 1/2 1/2 88 69 534 Y Y 1/2 1/2 686 1074 532 Y Y 1/2 1/2 387 365 632 924 529 Y Y N N 529 Y Y 1/2 1/2 266 435 514 N Y 1/2 3/4 105 141 509 Y Y 1/2 1/2 89 72 507 Y Y 3/4 1/2 252 415 500 Y Y 1/2 1/2 526 791 496 N Y 3/4 3/4 196 248 491 Y Y 1/2 1/2 620 712 490 N Y 3/4 1/2 39 12 490 N Y 1/2 3/4 138 250 485 Y N 1/2 1/2 666 702 7 471062 65+ Script Ranking 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 Drug Name Calcitriol Travatan Z Proventil HFA Benazepril/HCTZ Uroxatral Jantoven Phenazopyridine HCl Isosorbide Dinitrate Norvasc 4 Docusate Sodium Pentoxifylline 4 Tussionex Valtrex Nystatin Systemic Acyclovir Doxepin Sular Etodolac Nadolol Prednisone Intensol Theophylline SR Methocarbamol Indomethacin Ketoconazole Topical Primidone Astelin Patanol Keppra Tobradex Cefuroxime Axetil Diphenoxylate w/Atro Prochlorperaz Mal Hyoscyamine Albuterol Sulf/Iprat NovoLog Mix 70/30 Ipratropium Br Neb S Diltiazem Premarin Vaginal Catapres-TTS Byetta Diltiazem ER Novolin 70/30 4 Levitra Chantix Nasacort AQ Fortical Sucralfate Oxycodone HCL ER Lactulose Clarithromycin Acular LS Lescol XL Dexamethasone Oral Erythromycin Ophth 4 Phenobarbital Skelaxin Clarinex Prandin Generic/Active Ingredient calcitriol travoprost albuterol benazepril/hydrochlorothiazide alfuzosin warfarin phenazopyridine isosorbide dinitrate amlodipine docusate pentoxifylline hydrocodone/chlorpheniramine valacyclovir nystatin acyclovir doxepin nisoldipine etodolac nadolol prednisone theophylline methocarbamol indomethacin ketoconazole primidone azelastine olopatadine levetiracetam dexamethasone/tobramycin cefuroxime axetil diphenoxylate/atropine prochlorperazine hyoscyamine albuterol/ipratropium insulin human ipratropium diltiazem estrogens, conjugated clonidine exenatide diltiazem insulin human vardenafil varenicline triamcinolone acetonide calcitonin sucralfate oxycodone lactulose clarithromycin ketorolac tromethamine fluvastatin dexamethasone erythromycin phenobarbital metaxalone desloratadine repaglinide Brand/ Generic G B B G B B G G B G G B B G G G B G G G G G G G G B B B B G G G G G B G G B B B G B B B B B G G G G B B G G G B B B 2nd Highest Highest FEHBP with Estimated VA Enrollment Enrollment Highest Scripts Sales Sales National Medicare Medicare Enrollment For 65+ Ranking Ranking Formulary PDP PDP Formulary (in 000s) (all U.S.) Formulary Formulary (65+)2 Status3 Status Tier Status Tier Status 483 Y Y 1/2 1/2 276 467 483 Y Y 1/2 1/2 171 364 481 Y Y 1/2 1/2 295 230 480 N Y 1/2 1/2 514 684 479 N Y 3/4 3/4 172 300 478 Y Y 1/2 1/2 497 880 475 Y Y 1/2 1/2 754 815 471 Y Y 1/2 1/2 705 1209 469 Y Y 3/4 3/4 186 341 834 1166 468 Y N N N 466 N Y 1/2 1/2 461 818 234 171 466 N N N N 466 Y Y 1/2 1/2 100 20 465 Y Y 1/2 1/2 363 410 448 Y Y 1/2 1/2 510 418 445 Y Y 1/2 1/2 669 873 444 N Y 1/2 1/2 206 366 437 some forms Y 1/2 1/2 405 425 437 N N 1/2 1/2 516 706 436 Y Y 1/2 1/2 775 865 430 Y Y 1/2 1/2 504 789 428 Y N 3/4 1/2 564 549 425 Y Y 1/2 1/2 554 646 424 Y Y 1/2 1/2 438 447 422 Y Y 1/2 1/2 373 617 418 N Y 1/2 1/2 211 182 418 N Y 1/2 1/2 208 187 412 Y Y 1/2 1/2 64 45 408 Y Y 1/2 3/4 224 245 405 Y Y 1/2 1/2 416 404 404 Y Y 3/4 1/2 650 878 399 Y Y 1/2 1/2 612 773 396 N Y N 1/2 589 663 393 Y Y 1/2 N 161 295 389 Y Y 1/2 1/2 102 142 388 Y Y 1/2 1/2 362 590 387 Y Y 1/2 1/2 543 866 386 Y Y 1/2 1/2 207 284 385 Y Y 1/2 3/4 134 214 383 N Y 1/2 1/2 101 79 382 Y Y 1/2 1/2 314 526 381 Y Y 1/2 1/2 225 375 228 192 378 Y N N N 375 Y Y 3/4 3/4 181 65 369 N Y 3/4 3/4 223 154 368 Y Y 1/2 1/2 246 502 365 Y Y 1/2 1/2 439 616 364 N Y 1/2 1/2 87 61 361 Y Y 1/2 1/2 520 760 360 Y Y 1/2 1/2 431 352 355 N Y 1/2 3/4 241 470 355 Y Y 3/4 1/2 192 356 349 Y Y 1/2 1/2 683 805 348 Y Y 1/2 1/2 849 1006 732 746 345 Y Y N N 344 N N 3/4 3/4 150 99 342 N Y 3/4 3/4 197 178 336 N Y 3/4 1/2 152 292 Number of scripts and sales volume data were obtained from the Verispan Vector One National (VONA) database. VA formulary information was obtained from http://www.pbm.va.gov/NationalFormulary.aspx. The FEHBP with the highest enrollment is the BCBS Federal Employees Program Basic plan. The BCBS FEP Basic formulary was obtained from http://www.caremark.com/portal/asset/feprx_807.pdf. According to CMS data, the highest enrollment Medicare PDP is United AARP MedicareRx Preferred and the second highest enrollment Medicare PDP is Humana Standard. The United AARP formulary was obtained from https://www.aarpmedicarerx.com/online_documents/ovation/pdf/pdp/en/2009/ FLPDP3023174_XAPE002.pdf and the Humana formulary was obtained from http://apps.humana.com/marketing/documents.asp?file=906360. 1 Estimated sales for the 65+ population was based on the average price per prescription for the entire US population multiplied by the number of prescriptions for the 65+ population for that particular drug. 2 If more than 90% of the script volume for a particular drug was covered by the VA formulary, the entire drug is labeled as being on the VA formulary. If less than 5% of the script volume for a particular drug was covered by the VA formulary, the entire drug is labeled as being excluded from the VA formulary. If between 5% and 90% of the 3 8 471062 script volume for a particular drug was covered by the VA formulary, the drug is labeled as having “some forms” on the VA formulary. The highlighted drugs are not covered by Part D and were excluded from the analysis: Alprazolam, Aspirin (enteric-coat), Benzonatate, Cheratussin AC, Cialis, Clonazepam, Cyanocobalamin, Diazepam, Docusate Sodium, Ferrous Sulfate, Folic Acid, Levitra, Lorazepam, Phenobarbital, Promethazine/Codeine, Temazepam, Tussionex, Viagra, Vitamin D. The list of Part D excluded drugs was obtained from: www.cms.hhs.gov/PrescriptionDrugCovContra/Downloads/R2PDB.pdf. 4 9 471062