The psychometric properties of the CES-D 8 depression inventory and the estimation of cross-national differences in the true prevalence of depression. Sarah Van de Velde, Piet Bracke, Katia Levecque, Department of Sociology, Ghent University, Korte Meer 5, 9000 GHENT, Belgium. Abstract Cross-national comparisons of the prevalence of depression in the general populations are hampered by the absence of comparable data. Usually, cross-national differences are estimated using meta-analyses of data from a diverse set of studies using divergent depression inventories, different sampling designs, and not completely comparable sampling populations. Using information on the frequency and severity of depressive symptoms in the third wave of the European Social Survey (ESS round 3), we are able to fill this gap. In the ESS round 3 the frequency and severity of symptoms related to a DSM IV criterion for major depressive disorder is measured using a shorter version of the Epidemiological Studies Depression Scale or CES-D (Radloff 1977). The CES-D is a key instrument to measure the prevalence of depressive symptoms in society. Since its introduction the scale has been used to measure depressive symptoms across several populations (elderly, adolescents, women, clinical populations and ethnic populations). In a first step, we will evaluate the quality of this shortened version of the CES-D as a measurement instrument and the comparability of its measures across gender and across the European countries involved in the ESS. Using confirmatory factor analysis we will test the configural, metric and strong and strict factorial invariance, eliminating a possible measurement bias of the scale. In a second stage, best fitting factor models are used to estimate the ‘true’ frequency and severity of depressive symptoms for women and men in the 25 participating European countries. To the best of our knowledge, the present study is the first to present highly comparable data on the prevalence of depression in women and men in Europe. Introduction Cross-national gender differences in depression: a partly artificial fact? According to the World Health Organization, depression is the most common mental health problem in the Western world (WHO, 2000). It has a high prevalence in nearly every society with some studies even suggesting that depression is on the rise, at least in the Western world (Fombonne 1994;Kessler et al. 1993;Wauterickx and Bracke 2005;Weissman and Klerman 1992 ). A recurrent finding in international literature is a 1.5 to 3 times higher prevalence of depression in women compared to men (Weissman & Klerman, 1977; Weissman et al, 1984; Kessler et al, 1993; Piccinelli & Wilkinson 2000). This is true for both in- and outpatient as well as general population studies. The pattern of a higher prevalence of depression in women compared to men has been consistent across nations, cultures and population groups, in studies using different methods and measurement instruments and for a diversity of incidence and prevalence indicators (Weissman et al, 1984; Kessler et al, 1993). Unfortunately cross-national comparisons of the gender differences in depression in the general populations have been hampered by the absence of comparable data. Usually, crossnational differences are estimated using meta-analyses of data from a diverse set of studies using divergent depression inventories, different sampling designs, and not completely comparable sampling populations. In Europe three cross-national psychiatric epidemiological surveys went beyond these shortcomings and deliver comparable data: the Depress I and IIstudies, the ESEmed study, and the ODIN investigation. Nevertheless, these studies too have their shortcomings. The Depress II-study (Angst et al. 2002 ) allows for the estimation of gender differences in depression in a cross-national sample of treated individuals only. Moreover, like the first sample of the first pan-European study on depression, the Depress I (Lepine et al. 1997 ), this sample consists of only six countries. The ESEmed study (Alonso et al. 2004 ) too contains data of only six European countries. Finally, the ODIN study (AyusoMateos et al. 2001 ) holds information from individuals in nine urban centres and rural areas in five countries, albeit some of them were identified via primary care databases. Other studies containing information on depression and anxiety-related complaints are (a) the Survey of Health, Ageing and Retirement in Europe (SHARE) and (b) the WHO ‘Psychological Problems in Primary Care’ study. The first survey covers 11 European countries, but is limited to couples aged 50 and older (Börsch-Supan et al. 2005). The WHO-study sampled clients of 15 primary care centres in 14 countries (Maier et al. 1999 ). The samples were enriched with depressed cases, so they are not representative for the general population. In the present study, we made use of the third round of the European Social Survey (ESS 3), organized in 2006 and 2007 and covering data from 25 European countries. In the ESS 3 the frequency and severity of symptoms related to a DSM IV criterion for major depressive disorder is measured using a shorter version of the Center for Epidemiologic Studies Depression Scale or CES-D (Radloff 1977 ). The CES-D is a key instrument to measure the prevalence of depressive symptoms in society. Since its introduction the scale has been used to measure depressive symptoms across several populations (elderly, adolescents, women, clinical populations and ethnic populations). The ESS 3 thus allows us to compare gender differences in depression across multiple countries. An analysis of gender and cross-cultural differences in rates of depression presupposes that the underlying structure of responses to the depression scale in the participating countries shows measurement equivalence (Blasius & Thiessen 2006; Moors 2004; Van de Vijver 2003). The CES-D, like most other mental health assessment instruments, was initially developed and tested on samples comprised of mainly European Americans. Most research on the cross-cultural equivalence of the CES-D was done on populations within the United States and in a later stage with Hispanic or Asian populations. Unfortunately, cross-national validation of the CES-D across European countries is still lacking. A study of the validation of the translated version of the CES-D scale has been made for German populations (Hautzinger & Bailer 1993), for Dutch populations (Bouma et al. 1995), for the Belgian Population (Van de Velde, Levecque & Bracke 2008), for Turkish and Morrocan populations in the Netherlands (Spijker et al. 2004), for Portuguese populations (Gonçalves & Fagulha 2004) and for French populations (Fuhrer & Rouillon 1989). A recent study by Meads et al. (2006) assessed the comparability of the CES-D scale across a UK, Germany and US population but found a bad fit for the European countries. Previous studies on the measurement equivalence of the 20-item CES-D scale across gender groups are also ambivalent, with several studies pointing towards a gender bias (Callahan & Wolinsky, 1994; Cole et al, 2000; Stommel et al, 1993; Ross & Mirowky 1984) while other studies suggest measurement equivalence of the scale across gender groups (Berkman et al, 1986; Clark et al. 1981; Van de Velde, Levecque & Bracke 2008). Several other measurement inventories for depression also pointed towards a gender bias (Piccinelli & Wilkinson, 2000; Bracke 1996; Byrne et al. 1993; Mirowsky & Ross, 1995). In the ESS 3, depression was not assessed using the CES-D 20, but respondents were administered an 8-item version of the CES-D. While the CES-D 20 is used extensively in international research, the CES-D 8 has seldom been used before. Measurement equivalence and factorial invariance When depression is measured using a multi-item self-report instrument such as the CES-D, each item is considered an imperfect measure of one of the symptoms of depression, but as a whole, the set of items is hoped to provide a valid indirect assessment of a latent construct called depression. When the items are summed to form a composite measure, it is also assumed that the total measurement score will be more reliable than single item scores (Nunnally 1878). Measurement equivalence or invariance is the condition that is attained when individuals with equivalent true scores on a measurement instrument for a latent construct have the same probability of a particular observed score on an associated test (Meredith 1993). Measurement equivalence or invariance is the broader concept that subsumes factorial invariance. The latter is a measurement equivalence approximation that can be tested with confirmatory factor analysis (CFA), a special case of structural equation modeling. CFA is an excellent way of determining whether a hypothesized common factor underlies a scale and is currently the methodology of choice for assessed factorial invariance (Steenkamp & Baumgartner 1998; Stein et al. 2006). In the jargon of factor analysis, the common factor (i.e. depression) is an unobserved (latent) variable that is defined based on observed variables (i.e. the items of the CES-D 8 scale). The common factor is presumed to influence responses to the items (Meredith & Teresi 2006). CFA thus can be used to test whether this set of items construct an indirect measure of our common factor ‘depression’. While CFA allows testing factorial invariance of a construct in a single population group, multigroup CFA measures whether construct validity is invariant across two or more groups. The ESS 3 measures depression via a self-report instrument in multiple countries. This raises the question whether the items of our scale mean the same thing to people of these different cultures and language groups. In cross-cultural research, three types of bias can be distinguished: construct bias, item bias and method bias. (cf. Van de Vijver & Poortinga 1997). The first type of bias occurs when the construct measured, in this case depression, is not identical across groups. The definition of depression or the symptoms associated with it might differ slightly across groups, intruding the equivalence of the measurement. Item bias occurs most often when specific items of the depression scale are translated poorly, when there is low familiarity with the item content in certain cultures, or when cultural specifics such as nuisance factors or connotations associated with the item wording influence the measurement score (Van de Vijver 2003). Method bias finally, occurs when there is sample incomparability, instrument differences, interviewer of respondent effects or a difference in the mode of administration. In analysis, these forms of bias should be identified as measurement error. However, commonly used approaches such as ordinary least squares assume that variables have been measured without error (Brown 2006). Confirmatory Factor Analysis allows for relationships to be estimated after adjusting for measurement error and an error theory. It offers a very strong analytic framework for evaluating the equivalence of measurement models across distinct groups (e.g. demographic groups such as sexes and cultures). Available tests for multi-group comparison form a nested hierarchy defining several levels of factorial invariance: dimensional, configural, metric (also called pattern), strong factorial (also called scalar), and strict factorial invariance (Meredith 1993; Meredith & Teresi 2006; Bollen 1989; Byrne 1989; Gregorich 2006; Reise et al. 1993). A summary of these invariance hypotheses is presented in Table 1. At each level a more restrictive hypothesis is introduced providing increasing evidence of factorial invariance, and allowing specific group comparisons to be made. TABLE 1 A nested hierarchy of factorial invariance hypotheses (Source: based on Gregorich (2006) ) Invariance hypothesis Invariance test Dimensional Configural Metric (pattern) Strong factorial (scalar) Strict factorial (residual) Invariant number of common factors + invariant item/factor clusters + invariant factor loadings + invariant item intercepts + invariant residual variances Defensible substantive quantitative group comparisons None None Latent (co)variances + Latent and observed means + Observed (co)variances Hypotheses on the various levels of factorial invariance start with an unrestricted model in which no assumptions are made about the comparability of the various parameters across the groups under scrutiny. As Table 1 shows, this is the case for dimensional and configural factorial invariance. Respectively, they require that an instrument represents the same number of common factors across groups, and that each common factor is associated with identical item sets across groups. In the case of dimensional invariance, the underlying assumption is that instruments differing in the number of factors across groups indicate qualitative differences across these groups. In the CES-D 20 literature, the number of factors identified is usually four, namely depressed affect, positive affect, somatic, and interpersonal problems together loading on the common factor depression (Radloff 1997; Golding & Aneshensel 1989; Hertzog et al. 1990; Joseph et al. 1995; Roberts et al. 1989; 1990; Shafer 2006; Sheenan et al. 1995). For the CES-D 8, research on the structural form of the scale could not be found. However, based on the available items in the 8-item version and the identified structure of the full CESD, three structural forms can be hypothesized for the CES-D 8. The first is a one dimensional model, with all the items loading on one common factor depression. An alternative form is a two dimensional second-order factor model, built up by the factors depressed affect and somatic complaints, each loading on the underlying factor depression (Riddle et al 2002; Steffick 2000). However, many authors construct a distinct factor of the reversed worded items felt unhappy and did not enjoy life, proposing a three- rather than two-dimensional construct (Perreira 2005). However, we believe that the relationship among the reverse worded items is better accounted for by correlated errors than separate factors. The differential covariance among these items is not based on the influence of a distinct substantially important latent dimension, but rather reflects an artifact of response styles associated with the wording of the items (Brown 2006; Marsch 1996). The next form of factorial invariance, namely metric or pattern invariance, tests whether the common factors have the same meaning across groups, that is whether the factor loadings are equal across groups. Factor loadings represent the strength of the linear relation between each factor and its associated items (Bollen 1989). When the loading of each item on the underlying factor is equal across groups, the unit of measurement of the underlying factor is identical and the (co)variances of the estimated factors can be compared between groups. Group comparisons are defensible because the meanings of corresponding common factors are deemed invariant across groups and because the CFA model decomposes total item variation into estimated factor components (i.e. true scores) and errors (Gregorich 2006). Therefore, group differences in common factor variation and covariation are not contaminated by possible group differences in residual variation. Once the hypotheses of dimensional, configural and metric invariance are supported, a test of strong factorial or scalar invariance is in order. Such a test addresses the question whether there is differential additive response bias (Rorer 1965; Cheung & Rensvold 2000). Such bias is caused by forces – such as cultural norms - which are unrelated to the common factors, but systematically cause higher- or lower-valued item response in one population group compared to another. Within the CFA model, systematic additive influences on responses are reflected in the item intercepts. Since this response style is additive, it affects observed means but not response variation. According to Gregorich (2006) evidence that corresponding factor loadings and item intercepts are invariant across groups suggests that 1) group differences in estimated factor means will be unbiased and 2) group differences in observed means will be directly related to group differences in factor means and will not be contaminated by differential additive response bias. For most researchers comparison of group means is of main interest. Therefore the highest level of factorial invariance, namely residual invariance, is of limited practical value. Residual invariance, also called strict factorial invariance, allows comparisons of observed variance or covariance across groups. It is tested by constraining the residuals associated with each items to be equal across groups, in addition to the loadings and the intercepts of the model. In sum, measurement or factorial variance can take on several forms, contaminating estimates of latent constructs in several ways. Multi-group CFA allows to compare the means and variance of latent constructs by correcting for possible bias due to variation across groups in the number of common factors (dimensional invariance), the item/factor clusters (configural invariance), factor loadings (metric invariance), item intercepts (strong factorial invariance) and residual variances (strict factorial invariance). This is true for both the ‘full’ version of each form of factorial invariance, and for partial factorial invariance. Factorial invariance of any of the above mentioned types is said to be ‘full’ when all parameters are invariant across groups (e.g. full metric invariance means that all factor loadings are invariant across the groups under consideration); Partial factorial invariance applies to cases in which only some model parameters are invariant (Byrne et al 1989). According to Steenkamp and Baumgarten (1998), finding partial invariance suggests that the substantive group comparisons associated with the corresponding ‘full’ invariance hypotheses are defensible since only the subset of items meeting the metric, strong, or strict factorial invariance criteria are used to estimate associated group differences. Methods Data: The European Social Survey (ESS) 2006/2007 The European Social Survey (ESS3) (http://www.europeansocialsurvey.com) (Jowell et al. 2007) is a biennial survey covering 25 European countries in 2006 and 2007. The ESS is designed to chart and explain the interaction between Europe’s changing institutions and the attitudes, beliefs and behavior patterns of its diverse populations. In each participating country, the ESS-sample is designed following a strict randomized probability procedure and data is gathered with face-to-face interviews. The use of proxies was not allowed. ESS-information is representative for all individuals in the general population aged 15 and older, living in a private household, irrespective of their language, citizenship and nationality. After deleting cases lacking minimum information on gender or depression, our unweighted sample consists of 46.669 respondents. Response rate range from 45,97 percent in France to 73,19 percent in Slovakia. The CES-D 8 The Center of Epidemiological Studies Depression Scale or CES-D (Radloff 1977) is a key instrument in the measurement of depression in American research (Perreira 2005), but less often implemented within the European context. Initially, the CES-D was built by 20 self-report items in order to identify populations at risk of developing depressive disorders; in itself however, it should not be used as a clinical diagnostic tool (Radloff 1977; Perreira 2005; Steffick 2000). The 20 items primarily measure affective and somatic dimensions of depression, especially reflected in complaints such as depressed mood, feelings of guilt and worthlessness, helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance (Radloff 1977). Respondents are asked to indicate how often in the past week previous to the survey they felt of behaved in a certain way ranging from ‘none or almost none of the time’ to ‘all or almost or all of the time’. The response values are 4-point Likert scales, with range 0 to 3. Scale scores for the CES-D are assessed using non-weighted summated rating and range from 0 to 60 for the CES-D 20 and from 0 to 24 for the CES-D 8, with higher scores indicating a higher frequency of depressive complaints. International literature shows the CES-D 20 to have good psychometric properties (Radloff 1977, Shafer 2006; Sheenan 1995; Eaton et al. 2004). Shorter versions of the CES-D 20 have been used extensively before, but research based on the 8-item version is rather scarce. Based on the data of the ESS 3, we can confirm the reliability of the CES-D 8 for measurement of depression within a general population context. Reliability was indicated by a total response rate of 95% in men and 94% in women, lowest in Ukraine (77.1%) and highest in Norway (99,8%). Respondent mean substitution was applied to respondents answering at least 5 items of the scale. Respondents who answered to less than 5 items of the CES-D 8 scale (330 cases) or who did not report their gender (100 cases) were excluded from our analysis. Cronbach alpha of the CES-D 8 scale was 0.812 in male data and 0.847 in female data with the lowest score in Denmark (0,728) and highest in Hungary (0,881). The items building up the CES-D 8 are reported in Table 2. Consistent with international literature, we found higher levels of depression in women compared to men, with a mean score of 14.8 in women and 13.7 in men (F(1, 15147.037): 834.724; p<0.001). TABLE 2 Items of the 8-item version of the Center of Epidemiological Studies-Depression Scale (Jowell et al. 2007) How much of the time during the past week… Answers rage from 0 (None or almost none of the time) to 3 (All or almost all of the time) …you felt depressed? …you felt everything you did was an effort? …your sleep was restless? …you were happy? …you felt lonely? …you enjoyed life? …you felt sad? …you could not get going? Statistical procedure In order to compare depression scores across gender and countries, the CES-D 8 scale requires factorial invariance in both model form and model parameters (Bollen 1989). We estimated the best fitting model using Confirmatory Factor Analysis (CFA). This model is fitted to the data via Multiple Group Analysis using Maximum Likelihood estimations. Analysis is conducted using the AMOS 16.0 program. The analysis follows two phases: First, measurement invariance is hierarchically tested at each of the levels: dimensional, configural, metric, intercept and residual invariance. Second, we estimate the factor means of the depression construct for the different groups separately We then compare the estimated mean differences of our factor model with the observed mean differences of men and women. In our invariance tests, four specific model fit indicators are used. Commonly used in multigroup analyses, is the Chi²-test, testing the magnitude of the discrepancy between the sample and fitted covariance matrices (Chen 2000). When Chi² is significant, the model is rejected. However, the Chi² -test may easily lead to a type I error (and thus to an incorrect rejection of the model) in case of non-normality of data, large sample sizes and complex models (See Bollen (1989, 1990) for a detailed explanation of the influence of sample size on measures of model fit). Since the first two conditions are inherent in our study, we report the Chi²-test but add three model fit indices that showed a more robust performance in a simulation study by Hu and Bentler (1998): the Tucker-Lewis index (TLI) (Tucker & Lewis 1973), the Comparative Fit Index (CFI) (Bentler 1990) and the Root Mean Squared Error of Approximation (RMSEA) (Steiger 1990). The first two indices range from 0 (poor fit) to 1 (perfect fit). A value of 0,90 or higher provides evidence for a good fit, a value of 0,95 or above for an excellent fit (Hu & Bentler 1998). The RMSEA indicates a reasonable fit in case its score is 0,08 or less and a good fit in case the score is 0,05 or less (Browne & Cudeck 1992). When exploring partial factorial invariance models in addition to ‘full’ factorial models, the Modification Index (MI) procedure within AMOS 16.0 enables to relax the restriction on specific parameters in order to attain partial factorial invariance. The MI of a parameter is a conservative estimate of the decrease in chi-square that would occur if the parameter was relaxed (Arbuckle 2007). Thus we determine which cross-group equality constraint, if any, most significantly contributes to lack of fit; free that constraint; reestimate the model; and reiterate this process as needed (Gregorich, 2006). We restrict ourselves to significant MIs (3.84 and greater) (Byrne, Shavelson & Muthén 1989; Jöreskog & Sörbom 1984) and that can be substantially interpreted. In the current study we aim to determine whether the CES-D 8 scale is psychometrically equivalent across gender and countries involved in the ESS 3 by testing its factorial invariance. The different hypotheses of factorial invariance have been tested relatively infrequently in the past (Gregorich 2006). When they are tested, investigators have predominantly focused on invariance of construct validity (Vandenberg & Lance 2000) or on identifying biased items of the full 20-item and reducing its length (Cole 2000, Perreira 2005, Vega & Rumbaut 1991). The current study makes use of such an abbreviated CES-D scale and tests whether its equivalence can effectively be determined across gender and countries in the ESS 3. The aim of our study is therefore threefold. First, we determine the best fitting model for our data. This baseline model is then used to test the hierarchal hypotheses of factorial invariance allowing use to control for gender and cultural bias in the measurement of depression. Finally we use our model to estimate true depression score and compare these to the observed scores. To the best of our knowledge, the present study is the first to present highly comparable data on the prevalence of depression in women and men in Europe. Results Tests of factorial invariance hypotheses Table 3 gives an overview of the goodness-of-fit indices of the different levels of factorial invariance. First, the dimensional invariance hypothesis is tested by respectively fitting a oneand two dimensional model to our data (model 1a-1b). The analysis is repeated by additionally controlling for measurement effects of the reversed worded items felt unhappy and did not enjoy life (model 1c-1d). All models are identified by constraining the factor loading of the item felt depressed to 1. Results show that the one-dimensional model without any correlated errors, scores insufficiently on all four model fit indices: Chi² is significant, TLI and CFI are below the minimum level of 0.90 and RMSEA is far above the maximum level of 0.08. Distinguishing between a depressed affect factor and a somatic factor, results in a slightly better model fit as indicated by CFI=0.904, but all other indices suggest the model fits the data unsatisfactory. Model 1c and 1d with correlated errors between the reverse-worded items also have a significant Chi², but the three other indices show excellent fit: TLI and CFI above 0.90, RMSEA below 0.08. However, looking closer at the estimates of the two-factor model (results not shown here), indicates that this model includes a negative error variance, making its solution unacceptable. Based on these results we make use Model 1c with all items loading on one dimension and with a correlated errors between the reversed worded items as our baseline model for the upcoming multi-group CFA. As models 1e and 1f show, additional tests of the dimensional invariance hypothesis across gender on the one hand and across countries on the other hand suggest that our baseline model fits well in both multi-group analyses separately. TABLE 3 Model fit summary: Chi², CFI, TLI and RMSEA European Social Survey 2006-2007 (Jowell et al. 2007) Model Chi² Df Sign. CFI TLI RMSEA 1. Dimensional a. One factor b. Two factor c. One factor - correlated errors d. Two factor - correlated errors 12793.362 11585.181 2715.030 1839.087 20 19 19 18 0.000 0.000 0.000 0.000 0.894 0.904 0.978 0.985 0.852 0.858 0.967 0.976 0.117 0.114 0.055 0.047 e: Gender f: Countries 2756.209 4421.759 38 475 0.000 0.000 0.977 0.965 0.966 0.949 0.039 0.013 2. Configural 3. Metric 4a. Strong factorial 4b. Partial strong factorial 5a. Strict factorial 5b. Partial strict factorial 5026.743 6895.473 21371.629 12764.462 17314.392 13276.378 950 1293 1685 1573 1966 1762 0.000 0.000 0.000 0.000 0.000 0.000 0.964 0.950 0.824 0.900 0.863 0.897 0.946 0.946 0.854 0.911 0.902 0.918 0.010 0.010 0.016 0.012 0.013 0.012 Results of Model 2 and higher show the goodness of fit indices of the multi-group CFA with groups defined by gender and countries simultaneously. As model 2 in Table 3 shows, imposing equality constraints on the underlying items sets provides evidence for configural invariance for the CES-D 8 across gender and countries. The assumption that factor loadings are identical in both the male and female data in the different countries is also granted based on the findings in model 3. Although the metric invariance test shows a significant Chi², both the CFI and TLI suggest a very good fit as indicated by a score above 0.90. In addition, the RSMEA is smaller than 0.08, adding evidence for metric invariance of the scale across groups. The fourth model in Table 3 tests strong factorial invariance by additionally imposing equality constraints on corresponding item intercepts. We reject this model; Chi² is significant, and all fit indices except RMSEA are below the acceptable level. Based on the Modification Indices, we relaxed our model restrictions in order to meet partial strong factorial invariance (model 4b). Of all 400 constrained intercepts in our model, 112 needed to be relaxed for the model to show an acceptable fit, with largest decrease in Chi² in Hungarian females and secondly in Finish males. The relaxation resulted in total decrease in Chi² of 8607.167. These findings suggest that comparisons across gender of factor and observed means of the CES-D 8 are defensible. In order to legitimately compare the observed (co)variances of depression in men and women, the highest level of factorial invariance needs to be verified. This is tested by additionally constraining all corresponding item residual variances. Model 5 shows that the hypothesis of strict factorial invariance is empirically rejected (both CFI and TLI are below 0.90). After relaxing all significant Modification Indices (MI>3.84), we also reject the hypothesis of partial strict factorial invariance, with a CFI level still below 0.90. In sum, the findings for all models in Table 3 indicate that the one-dimensional CES-D 8 scale with correlated errors of the reverse-worded items can be used to compare factor means and observed means, but not factor (co)variances and observed (co)variances between genders and countries. Comparison of observed means The factorial invariance tests reported in Table 3 showed empirical evidence for the hypotheses of partial strong factorial invariance, indicating that comparisons of observed means of the CES-D 8 across gender and countries is warranted. Based on this model we estimated the mean score of the CES-D 8 factor for each group. Factor scores attained from the model were used as weights to correct the observed scores by the model specification. Because of its stable conditions in Multi-group CFA, we identified the Estonian males as our reference group. As the factor mean differences indicate gender differences in the overall scores on the best fitting factor model, irrespective of culture specific and gendered item response styles, they can be regarded as very conservative, gender and culture neutral estimates of the gender difference in depression. Results of these estimated scores are shown in table 4, along with the observed means and their standard deviations. Our observed scores indicate that female respondents score significantly higher on the CES-D 8 scale than male respondents in all countries, except in Ireland and Finland, where the difference is not significant. The gender difference is largest in Portugal (∆ = 1,829, p<0,000) and smallest in Ireland (∆ = 0,098, n.s.). Ukrainian females and Hungarian males report the highest depression level of their sex, with a mean score of respectively 17,439 and 16,133. Lowest depression levels in each sex are reported by Norwegian females (mean of 12,494) and Norwegian males (mean of 12,037). Also the estimated scores confirm a higher prevalence of depression in females in all countries. This difference is significant in all countries except Ireland. The estimated scores indicate largest difference in depression between Portuguese males and females (∆ = 2.803), and secondly in Russian males and females (∆ = 2,506). Smallest differences were found in Ireland (∆ = 0,104) and Norway (∆ = 0,016). The impact of our model was highest in Slovenia, with gender difference in depression deviating 1,039 points from the observed score. Second in line is Portugal with a difference between estimated and observed scores of 0.975 points, third France with a difference of 0.853 points. Model correction in scores was smallest in Ireland (0,007 points), the Netherlands (0,077 points) and Norway (0,128 points). TABLE 4 Comparison of observed mean scores and standard deviations with estimated mean scores and standard deviations. European Social Survey 2006-2007 (Jowell et al. 2007) OBSERVED SCORES Male Mean ESTIMATED SCORES Female S.D. Mean S.D. Male ∆; p Female Mean S.D. Mean S.D. ∆; p Austria 13.227 3.769 13.754 4.161 0.527; 0.001 11.028 3.314 11.855 3.821 0.828; 0.000 Belgium 12.738 3.768 14.070 4.335 1.331; 0.000 10.663 3.320 12.393 4.104 1.730; 0.000 Bulgaria 15.247 4.788 16.539 5.018 1.292; 0.000 13.707 4.802 15.562 5.147 1.856; 0.000 Switzerland 12.387 3.138 13.080 3.509 0.692; 0.000 9.675 2.557 10.749 3.031 1.073; 0.000 Cyprus 12.457 3.144 14.022 3.902 1.565; 0.000 9.021 2.308 11.290 3.270 2.269; 0.000 Germany 13.653 3.470 14.490 3.917 0.837; 0.000 10.542 2.909 12.072 3.518 1.530; 0.000 Denmark 12.496 3.117 13.023 3.507 0.527; 0.002 9.081 2.469 10.301 3.018 1.220; 0.000 Estonia 14.315 3.772 15.163 4.142 0.848; 0.000 11.650 3.249 13.265 3.777 1.615; 0.000 Spain 12.858 3.810 14.348 4.531 1.490; 0.000 11.266 3.634 13.355 4.499 2.089; 0.000 Finland 12.817 3.140 13.108 3.484 0.291; 0.057 9.025 2.371 10.165 2.969 1.141; 0.000 France 12.898 3.739 14.250 4.625 1.352; 0.000 10.486 3.251 12.691 4.389 2.205; 0.000 United Kingdom 13.444 4.028 14.162 4.299 0.718; 0.000 11.214 3.469 12.166 3.910 0.952; 0.000 Hungary 16.133 4.984 17.084 5.206 0.951; 0.000 15.472 5.081 16.821 5.326 1.349; 0.000 Ireland 12.837 3.669 12.934 3.612 0.098; 0.579 10.443 3.163 10.548 3.065 0.104; 0.489 Latvia 15.478 3.847 16.206 3.769 0.728; 0.000 13.462 3.619 14.386 3.565 0.925; 0.000 Netherlands 12.710 3.495 13.878 3.947 1.169; 0.000 10.534 3.029 11.780 3.539 1.246; 0.000 Norway 12.037 3.008 12.494 3.222 0.458; 0.002 9.899 2.687 10.229 2.834 0.330; 0.013 Poland 13.921 4.425 15.285 5.148 1.364; 0.000 12.153 4.101 14.295 5.184 2.142; 0.000 Portugal 14.637 3.951 16.466 4.738 1.829; 0.000 12.484 3.768 15.288 4.933 2.803; 0.000 Romania 14.780 3.827 15.921 4.019 1.140; 0.000 11.659 3.387 13.300 3.735 1.641; 0.000 Russian Fed. 15.116 4.348 16.828 4.667 1.712; 0.000 13.670 4.196 16.176 4.687 2.506; 0.000 Sweden 12.455 3.411 13.520 4.146 1.064; 0.000 9.609 2.814 11.360 3.750 1.751; 0.000 Slovenia 13.327 3.280 14.207 4.225 0.880; 0.000 10.694 2.756 12.613 4.036 1.919; 0.000 Slovakia 15.181 3.817 15.694 4.083 0.513; 0.007 12.366 3.308 13.665 3.671 1.300; 0.000 Ukraine 15.686 4.674 17.439 5.068 1.754; 0.000 14.163 4.457 16.405 4.941 2.242; 0.000 Total 13.670 3.957 14.813 4.496 1.143; 0.000 11.287 3.743 13.035 4.500 1.749; 0.000 We used general linear modeling to decompose the variance in the observed and the true mean depression scores in within and between gender variance and within and between countries variance components. Results (not reported here) show that modifying the depression scores according to the best fitting factor model drastically enhances the proportion of the between gender and the between countries variance within the total gender and countries variance. For the observed depression scores the within gender variance equals 1.1 % of the total variance, while for the true depression scores the measure equals 3.0 %. Analogues figures are 7.5 % and 16.1 % for the between countries variance component. This shift points to a drastically enhanced reliability of the indicator. The differences in the ranking of the countries based on the true depression scores and the estimated factor mean scores signal the impact of gender and culture related symptom differences in depression. For instance, depression in Portuguese women is more strongly related to feelings of sadness, and not being able to get going; while among Finnish women, feeling depressed was pivotal as was the case among Hungarian women. Among Austrian and Hungarian men feeling that everything they did was an effort carried more weight, while among Portuguese men this complain was rather irrelevant. Feelings of loneliness are important among Swiss and Danish men. Overall, the symptoms depressed, effort and get going showed the largest gender*country variation in expression. Finally, overall modifications of the factor model were largest among the Portuguese, the Hungarian, the Finnish, and the Ukrainian. Discussion Simultaneous analysis of multiple groups places higher demands on the measurement scale than single-group research. It requires that instruments measure constructs with the same meaning across groups and allow defensible quantitative group comparisons. In this study, we used a scale that measures depression by assessing the frequency and occurrence of certain depressive symptoms. Depression is thus considered to be a latent construct whose properties are inferred from observing the set of variables that serve as manifest indicators. If the mean depression score of men differs from that of women across countries, what can be concluded? It may be the case that these groups actually differ in their level of depression, it may also be the case that extraneous influences are giving rise to the observed differences (Meredith & Teresi 2006). Therefore factorial invariance needs to be tested in quantitative comparative research. Unfortunately, factorial invariance has been tested relatively infrequent in past research. When it is tested, researchers predominantly focused on invariance of the factor construct (Vandenberg & Lance 2000). The number of studies that determine whether comparisons of group means are defensible has increased in recent years, but its application is not yet widely used and scattered across different domains. Lack of requisite technical skills or lack of awareness might explain the scarceness of these types of invariance studies (Gregorich 2006). In the present study we established factorial invariance at all levels except strict factorial invariance. Strong factorial invariance was partially established after relaxing a substantial amount of intercepts. Next we estimated depression mean scores across gender and countries, eliminating a measurement artifact. Our results indicate that the CES-D 8 scale can be used to compare mean differences in depression of men and women across countries, showing good reliability and validity. Our study based on the third round of the European Social Survey covering 25 European countries confirms the consistent epidemiological finding that women report more complaints of depression than men. Our results also suggest that the true gender difference in depression is larger than the observed answers of our population on the 8 item short version of the CES-D. Some limitations of our study are worth noting when interpreting the results. When testing factorial invariance in large community samples such as the ESS3, the researcher should also bear in mind that the variables of interest are often non-normally distributed, specifically when working with ordinal Likert scales (Lubke & Muthen 2004). However, the maximum likelihood estimation method assumes that data have a normal distribution. In our analyses, we tested the robustness of our findings by additionally estimating a Bollen-Stine significance level via bootstrapping, a procedure compensating for the normality assumption (Fouladi 1997, Nevitt & Hancock 1997). Results (not shown) did not indicate a different significance level than the one reported for the Chi² tests. An additional robustness test was based on a logarithmic transformation of the CES-D 8 data, decreasing the non-normality of the item and scale score distributions. This procedure results in better fit-indices (not shown), but it simultaneously increases the complexity of a substantive interpretation of the parameter estimates. Important to note is that the hypotheses of factorial invariance were supported by all estimations methods even after controlling for non-normality. In our analysis some intercepts were found to vary across our groups, whereas others were invariant, resulting in partial strong factorial invariance. We based our decision to relax a certain intercept on significant modification indices as provided by AMOS 16.0. This was only done if the intercept to be relaxed could be substantially interpreted. How should we then interpret our partial strong factorial model? In our analysis 112 of the 400 intercepts were relaxed. We have three options on what to do with our scale. One option might be to omit the items that were found to perform differently across groups. A second option might be to retain all 8 items of the CES-D 8 scale in the belief that the population differences in factor structure are “small” in some sense and that these differences will not obscure inferences from the scale. A third option might be to abandon the use of the scale altogether for comparisons across populations, reasoning that the lack of invariance establishes that the scale is measuring different latent variables in the two populations. Unfortunately the current literature on factorial invariance offers little guidance in choosing among these three options (Millsap & Kwok 2004). Finally, the current findings do not automatically imply psychometric equivalence across social groups distinguished by other criteria such as language, ethnicity, social class or age. All these social groups may have group-specific attributes that lead to measurement inequivalence of (self-report) scales. We therefore strongly suggest to test factorial invariance before comparing specific group scores. The actual experience and expression of depression may vary sufficiently according to other demographic and social or cultural factors to effectively undermine attempts to compare rates of depressive symptoms across all groups. Further research is needed to determine the extent to which these factors influence responses to self-report instruments. 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