Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 1 of 33 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION ) CIVIL ACTION NO. 03- 12628-NG STIPULATION AND AGREEMENT OF SETTLEMENT This Stipulation and Agreement of Settlement (the "Stipulation ) is submitted pursuant to Rule 23 of the Federal Rules of Civil Procedure. Subject to the approval of the Court, this Stipulation is entered into among : (i) Lead Plaintiff Ronald Erickson ("Erickson ) and Plaintiff John G. Esposito ("Esposito ) (together the "Plaintiffs or the "Class Representatives ) on behalf of themselves and all Class Members (as hereinafter defined), by and through their undersigned attorneys ; and (ii) Biopure Corporation ("Biopure ), Thomas A. Moore, Carl W. Rausch, Ronald F. Richards, Howard P. Richman, Charles A. Sanders and J. Richard Crout (collectively, "Defendants ), by and through their undersigned attorneys (collectively, Class Representatives and Defendants shall be referred to herein as the "Parties ). I. THE ACTION A. The Filed Actions On or after December 30, 2003, fifteen securities class actions were filed in the United States District Court for the District of Massachusetts against Biopure and certain of Biopure's present or former officers: Greene v. Biopure Corporation et al., Civ. No. 03-12628-NG; Esposito v. Biopure Corporation et al., Civ. No. 04-10013-NG; King v. Biopure Corporation et al., Civ. No. 04-10038-NG; Criden v. Biopure Corporation et al., Civ. No. 04-10046-NG; ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 2 of 33 Shurkin et al. v. Biopure Corporation et al., Civ. No. 04-10055 -NG; Nizzo v. Biopure Corporation et al., Civ. No. 04-10065-NG; Brooks v. Biopure Corporation et al., Civ. No. 0410077-NG; Perlegis v. Biopure Corporation et al., Civ. No. 04-10078-NG; Weber v. Biopure Corporation et al., Civ. No. 04-10090-NG; Haims v. Biopure Corporation et al., Civ. No. 0410144-NG; Model Partners Limited v. Biopure Corporation et al., Civ. No. 04-10155-NG; Patenaude v. Biopure Corporation et al., Civ. No. 04-10179-NG; Pinckney v. Biopure Corporation et al., Civ. No. 04-10189-NG; Johnson v. Biopure Corporation et al., Civ. No. 0410190-NG; and Kruszka v. Biopure Corporation et al., Civ. No. 04-10202-NG. On May 14, 2004, the Court ordered the complaints consolidated into a single action under the caption In re Biopure Securities Litigation , Civ. No. 03-12628-NG (the "Action ) The Court also appointed Ronald Erickson as Lead Plaintiff and approved Stull, Stull & Brody ("Stull ) and Shapiro Haber & Urmy, LLP (" Shapiro ) as Co-Lead Counsel (together, Stull and Shapiro shall be referred to as "Co-Lead Counsel ). B. Procedural History On July 23, 2004, the Class Representatives and other named Plaintiffs filed a Consolidated Amended Class Action Complaint ("CAC ) alleging claims under Section 10(b) of the Securities Exchange Act of 1934 (the "Exchange Act ) and Rule lOb-5 promulgated thereunder, Section 20(a) of the Exchange Act and Section 20A of the Exchange Act. On October 6, 2004, all Defendants filed a motion to dismiss the CAC . On December 7, 2004, plaintiffs filed their opposition to the motion. On January 24, 2005, Defendants filed their reply. On January 5, 2006 the Plaintiffs filed a motion for leave to file a Second Consolidated Amended Complaint ("SCAC ). On January 23, 2006 the Defendants filed their opposition to that motion. 2 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 3 of 33 On February 2, 2006 the Court held a hearing on Defendants' motion to dismiss and the plaintiffs ' motion for leave to file the SCAC. The Court issued a Memorandum and Order denying the Defendants ' motion to dismiss and granting the Plaintiffs leave to file the SCAC ("the Order ) on March 28 , 2006 . On the same date , the Plaintiffs filed the SCAC, which raised the same legal claims as were set forth in the CAC, but supported them with additional factual allegations. On April 28, 2006 Defendants filed their Answer and Affirmative Defenses to the SCAC. On May 5, 2006 the Class Representatives and named Plaintiff Stuart Gottlieb filed a motion to certify: (i) a class of purchasers of Biopure common stock from April 9, 2003 through December 24, 2003, with Lead Plaintiff Erickson seeking to serve as Class representative; and (ii) a SubClass of purchasers of Biopure common stock who purchased contemporaneously with sales by Biopure and Rausch, with named Plaintiffs Esposito and Gottlieb as Sub-Class representatives. Defendants served Lead Plaintiff Erickson and Plaintiffs Gottlieb and Esposito with class certification related discovery, including document requests, interrogatories and deposition notices, and conducted third party class certification discovery with respect to Lead Plaintiff Erickson, Plaintiff Gottlieb and Plaintiff Esposito. Lead Plaintiff Erickson and Plaintiff Esposito sat for their depositions on May 30 and May 31, 2006, respectively. On June 5, 2006, the Class Representatives filed an amended motion for class certification, seeking to certify : (i) a class of purchasers of Biopure common stock from April 9, 2003 through December 24, 2003, with Lead Plaintiff Erickson and named Plaintiff Esposito seeking to serve as class representatives; and (ii) a sub-class of purchasers of Biopure common stock who purchased contemporaneously with sales by Biopure and Rausch with named Plaintiff 3 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Esposito seeking to serve as sub-class representative . Page 4 of 33 The members of the above-referenced class and sub-class are collectively referred to herein as the "Class Members. Defendants filed a memorandum in opposition to the amended motion for class certification on July 25, 2006. Plaintiffs replied on September 29, 2006 and Defendants surreplied on October 13, 2006. The amended motion to certify the Class was pending on February 6, 2007, when the Parties notified the court that they had reached a settlement. II. INVESTIGATION, DISCOVERY AND RESEARCH A. Investigation, Discovery and Research Conducted by Co-Lead Counsel Co-Lead Counsel have conducted extensive discovery and factual investigation during their prosecution of the Action. This discovery and investigation has included, inter alia, (a) review and analysis of Biopure's public filings, annual reports, and other public statements; (b) review of transcripts of testimony in a related proceeding by the SEC; (c) consultations with experts; (d) research of the applicable law with respect to the claims asserted in the Action and the potential defenses thereto; (e) detailed review and analysis of over 40,000 pages of documents produced by Defendants in discovery. Based upon their investigation to date , Co-Lead Counsel believe that the terms and conditions of this Stipulation are fair, reasonable and adequate to the Class Representatives and the Class Members, and in their best interests, and the Class Representatives have agreed to settle the claims raised in the Action pursuant to the terms and provisions of this Stipulation, after considering (a) the substantial benefits that Class Representatives and the Class Members will receive from the Settlement; (b) the attendant risks of litigation; and (c) the desirability of permitting the Settlement to be consummated as provided by the terms of this Stipulation. B. Settlement Negotiations and Mediation 4 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 5 of 33 The Parties began to discuss a possible resolution of this action early in the proceedings. Discussions between the Parties continued for many months, resulting in a mediation held in September 2005 and conducted by the Honorable Layn Phillips (Ret.), United States District Court Judge for the Western District of Oklahoma. Although the mediation with retired Judge Phillips failed to result in a settlement, the Parties continued to discuss the possibility of settlement and engaged in another mediation on October 11, 2006, conducted by Professor Eric Green. Following the mediation with Professor Green, the Parties continued to negotiate the terms of a potential settlement and ultimately, the Parties reached the settlement set forth herein. III. PLAINTIFFS' CLAIMS AND BENEFITS OF SETTLEMENT The Class Representatives believe that the causes of action asserted in the SCAC have merit and that the evidence developed to date supports their claims. The Class Representatives have collected evidence through discovery and investigation that they strongly believe would demonstrate at trial that Defendants knowingly and/or recklessly issued, or caused Biopure to issue, materially false and/or misleading statements concerning the business, operations and financial condition of Biopure, which caused the price of Biopure common stock to be artificially inflated during the Class Period (as defined below) and resulted in injury to the Class Representatives and the Class Members. Even though the Class Representatives have survived Defendants ' motion to dismiss, have briefed the issue of class certification, and believe their claims are strong, they recognize and acknowledge the expense and length of time which would be consumed by continued proceedings necessary to prosecute the Action against the Defendants through trial and appeals. Co-Lead Counsel have also taken into account the uncertain outcome and the risk of any litigation, especially in complex actions such as this Action, as well as the difficulties and delays 5 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 6 of 33 inherent in such litigation. Co-Lead Counsel are also mindful of the inherent problems of proof under, and possible defenses to, the securities law violations asserted in the Action. Further, CoLead Counsel also considered the ability to pay issues arising from the financial circumstances of Biopure and the ability to fund a settlement or satisfy a verdict from insurance proceeds, which have been used in part to defend this Action and a related action prosecuted by the SEC. In light of the foregoing, the Class Representatives and Co-Lead Counsel believe that the Settlement confers substantial benefits upon the Class and they have determined that the Settlement set forth in the Stipulation is in the best interests of the Class Representatives and the Class Members. IV. DEFENDANTS' DENIAL OF WRONGDOING AND LIABILITY Defendants have denied and continue to deny each and all of the claims and contentions alleged by the Class Representatives in the Action. Defendants expressly have denied and continue to deny all charges of wrongdoing or liability against them arising out of any conduct, statements , acts or omissions alleged, or that could have been alleged, in the Action. Defendants have also denied and continue to deny, inter alia, the allegations that Class Representatives or the Class have suffered damages, that the price of Biopure common stock was artificially inflated by reasons of alleged misrepresentations, non-disclosures or otherwise, and that the Class Representatives or the Class were harmed by the conduct alleged in the SCAC. Nonetheless, Defendants have concluded that further conduct of the Action would be protracted and expensive, and that it is desirable that the Action and any Settled Claims, including Unknown Claims (as defined below), be fully and finally settled in the manner and upon the terms and conditions set forth in this Stipulation. Defendants have also taken into account the uncertainty and risks inherent in any litigation, especially in complex securities cases 6 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 7 of 33 like this Action. Defendants, therefore, have determined that it is desirable and beneficial to them that the Action be settled in the manner and upon the terms and conditions set forth in this Stipulation. V. TERMS OF STIPULATION AND AGREEMENT OF SETTLEMENT NOW THEREFORE, without any admission or concession on the part of Class Representatives of any lack of merit of the Action whatsoever, and without any admission or concession of any fault, liability, wrongdoing or damage whatsoever, or lack of merit in the defenses whatsoever, by the Defendants , it is hereby STIPULATED AND AGREED, by and among the Parties to this Stipulation, through their respective attorneys, subject to approval of the Court pursuant to Rule 23(e) of the Federal Rules of Civil Procedure, in consideration of the benefits flowing to the Parties hereto, that all Settled Claims (as hereinafter defined) as against the Released Parties (as hereinafter defined) and all Settled Defendants' Claims (as hereinafter defined) shall be compromised, settled, released and dismissed with prejudice, upon and subject to the following terms and conditions (the "Settlement ) DEFINITIONS 1. As used in this Stipulation, the following terms shall have the following meanings: (a) "Authorized Claimant means any Class Member who submits a timely and valid Proof of Claim and Release form ("Proof of Claim ) that is accepted by the Claims Administrator. (b) "Claimant means any Class Member who files a Proof of Claim. (c) "Claims Administrator which shall administer the Settlement. 7 ACTIVE/72007843.1 means Berdon Claims Administration LLC, Case 1:03-cv-12628-NG (d) Document 163 Filed 05/17/2007 Page 8 of 33 "Class and "Class Members mean all persons or entities who purchased or otherwise acquired Biopure common stock from April 9, 2003 through December 24, 2003, inclusive. Excluded from the Class are Defendants, the former and current officers and directors of Biopure, members of their immediate families and their legal representatives, heirs, successors or assigns and any entity in which Defendants have or had a controlling interest. (e) "Class Period means the period of time from April 9, 2003 through December 24, 2003, inclusive. (f) "Court means the United States District Court for the District of Massachusetts, the Honorable Nancy Gertner presiding. (g) "Defendants means Biopure Corporation, Thomas A. Moore, Carl W. Rausch, Ronald F. Richards, Howard P. Richman, Charles A. Sanders and J. Richard Crout. (h) "Defendants' Counsel means the law firm of Bingham McCutchen, LLP. (i) "Effective Date of Settlement or "Effective Date means the date upon which the Settlement contemplated by this Stipulation shall become effective, as set forth in ¶27 below. 0) "Escrow Agents means Co-Lead Counsel, Edward F. Haber and Howard (k) "Final means : (i) if an appeal is filed, the date of final affirmance on an Longman. appeal from the Order and Final Judgment, the expiration of the time for a petition for a writ of certiorari to review the Order and Final Judgment or, if certiorari is granted, the date of final affirmance of the Order and Final Judgment following review pursuant to that grant; or (ii) the date of final dismissal of any appeal from the Order and Final Judgment and the final dismissal of any proceeding on certiorari to review the Order and Final Judgment; or (iii) if no appeal is 8 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 9 of 33 filed, the expiration date of the time for the filing or noticing of any appeal from the Order and Final Judgment, i.e., thirty (30) calendar days after entry of the Order and Final Judgment (or, if the date for taking an appeal or seeking review shall be extended beyond this time by order of the Court, by operation of law or otherwise, or if such extension is requested, the date of expiration of any extension if any appeal or review is not sought); or (iv) if the Court enters an Order and Final Judgment in a form other than that provided above ("Alternative Judgment ) and none of the Parties hereto elect to terminate the Settlement, the date that such Alternative Judgment becomes final as defined in parts (i) to (iii) above and no longer subject to appeal or review. Any proceeding or order, or any appeal or petition for a writ of certiorari pertaining solely to any plan of allocation and/or application for attorneys' fees, costs or expenses, or compensatory award for Class Representatives shall not in any way delay or preclude the Order and Final Judgment from becoming final. (1) "Gross Settlement Fund means the Settlement Amount, plus any interest earned thereon. (m) "Insurers means the Underwriters of Lloyd's, London; Old Republic Insurance Company; and Carolina Casualty Insurance Company (the "Insurers ). (n) "Class Representatives means Lead Plaintiff Ronald Erickson and Plaintiff John G. Esposito. (o) "Co-Lead Counsel means Stull , Stull & Brody and Shapiro Haber & (p) "Net Settlement Fund Urmy, LLP. means the Gross Settlement Fund, as defined herein, net of any taxes, as referred to in ¶7, on the income thereof, and net of any funds to pay (i) the notice and administrative costs referred to in ¶11, (ii) taxes and escrow fees; (iii) the 9 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 10 of 33 attorneys' fees and expense award referred to in ¶12; and (iv) any award to Class Representatives granted by the Court referred to in ¶12. (q) "Notice means the Notice of Proposed Settlement of Class Action, Motion for Attorneys' Fees and Settlement Fairness Hearing, which is to be sent to members of the Class substantially in the form attached hereto as Exhibit 1 to Exhibit A. (r) "Order and Final Judgment means the proposed order to be entered approving the Settlement substantially in the form attached hereto as Exhibit B. (s) "Person means an individual, corporation (including all divisions and subsidiaries), partnership, limited partnership, association, joint stock company, estate, legal representative, trust, unincorporated association, government or any political subdivision or agency thereof, and any business or legal entity and their spouses, heirs, predecessors, successors, representatives or assigns. (t) "Plan of Allocation means a plan or formula for the allocation of the Net Settlement Fund whereby the Net Settlement Fund shall be distributed to Authorized Claimants. (u) "Preliminary Approval Order means the proposed order preliminarily approving the Settlement and directing notice thereof to the Class substantially in the form attached hereto as Exhibit A. (v) "Released Parties means any and all of the Defendants, their past or present subsidiaries, parents, successors and predecessors, officers, directors, agents, employees, Insurers, co-insurers, reinsurers, controlling shareholders, attorneys, divisions, joint ventures, accountants, spouses, personal or legal representatives, assigns, heirs, any members of an Individual Defendant's immediate family and any trust of which any Individual Defendant is the settlor or which is for the benefit of an Individual Defendant's family, and any person, firm, 10 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 11 of 33 trust, corporation, officer, director or other individual or entity in which any Defendant has a controlling interest or which is related to or affiliated with any of the Defendants , and the legal representatives , heirs, successors in interest or assigns of any such party. (w) "Settled Claim(s) means any and all claims, including both known claims and Unknown Claims (as defined below), debts, demands, rights or causes of action or liabilities of every nature and description whatsoever (including, but not limited to, any claims for damages, interest, attorneys' fees, expert or consulting fees, equitable or injunctive relief and any other costs, expenses or liability whatsoever), whether based on federal, state, local, statutory or common law or any other law, rule or regulation, whether fixed or contingent, accrued or unaccrued, liquidated or unliquidated, at law or in equity, matured or unmatured, whether class or individual in nature, known or unknown, whether concealed or hidden, asserted or that could have been asserted, including, without limitation , claims for negligence, gross negligence , breach of duty of care and/or breach of duty of loyalty, fraud, breach of fiduciary duty, or violations of any state or federal statutes, rules or regulations , (i) that have been asserted in this Action by the Class Members or their attorneys or any of them against any of the Released Parties, or (ii) that could have been asserted in any forum by the Class Members or their attorney or any of them or their successors and assigns or any of them against any of the Released Parties which arise out of or are based upon or relate in any way to the allegations, transactions, facts, matters or occurrences, representations or omissions involved, set forth, or referred to in the SCAC or relate in any way to the purchase, sale or acquisition of Biopure common stock during the Class Period except for claims to enforce the Settlement. (x) "Defendants' Settled Claims means any and all claims, debts, demands, rights or causes of action or liabilities whatsoever (including, but not limited to, any claims for 11 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 12 of 33 damages, interest, attorneys' fees, expert or consulting fees, equitable or injunctive relief and any other costs, expenses or liability whatsoever), whether based on federal, state, local, statutory or common law or any other law, rule or regulation, whether fixed or contingent, accrued or unaccrued, liquidated or unliquidated, at law or in equity, matured or unmatured, whether class or individual in nature, including both known claims and Unknown Claims (as defined below), that have been or could have been asserted in the Action or any forum by the Defendants or any of them or the successors and assigns of any of them against any of the Class Representatives, Class Members or their attorneys, which arise out of or relate in any way to the institution, prosecution, or settlement of the Action (except for claims to enforce the Settlement). (y) "Settlement Amount means the consideration to be paid by the Insurers on behalf of the Defendants pursuant to the Settlement set forth herein, which consideration shall be TEN MILLION DOLLARS ($ 10,000 ,000.00) total, consisting of the First Deposit (as defined below), the Second Deposit (as defined below), and the Third Deposit (as defined below). (z) "Summary Notice means the Summary Notice of Settlement for publication substantially in the form attached as Exhibit 3 to Exhibit A. (aa) "Unknown Claims means any and all claims , rights or causes of action or liabilities whatsoever, whether based on federal, state, local, statutory or common law or any other law, rule or regulation which any Lead Plaintiff or Class Member does not know or suspect to exist in his, her or its favor at the time of the release of the Released Parties, and any Defendants' Settled Claims which any Defendant does not know or suspect to exist in his, her or its favor at the time of the release of the Defendants' Settled Claims, which, if known by him, her or it, could have been asserted in any forum by the Class Members or any of them against any of the Released Parties which relate to the purchase, sale or acquisition of common stock of 12 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 13 of 33 Biopure during the Class Period, even if unknown at the time of execution of this Stipulation, or could have been asserted by the Defendants against the Lead Plaintiff or Class Members relating to the Action, even if unknown at the time of the execution of this Stipulation. With respect to any and all Settled Claims and Defendants' Settled Claims, the Parties stipulate and agree that upon the Effective Date, the Class Representatives and the Defendants shall expressly, and each Class Member shall be deemed to have, and by operation of the Order and Final Judgment shall have, expressly waived any and all provisions , rights and benefits conferred by any law of any state or territory of the United States, or principle of common law, which is similar, comparable, or equivalent to Cal. Civ. Code § 1542, which provides: A general release does not extend to claims which the creditor does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor. The Class Representatives and Class Members may hereafter discover facts in addition to or different from those which he, she or it now knows or believes to be true with respect to the subject matter of the Settled Claims, but the Class Representatives shall expressly fully, finally and forever settle and release, and each Class Member, upon the Effective Date, shall be deemed to have, and by operation of the Judgment shall have, fully, finally and forever settled and released any and all Settled Claims, known or unknown, suspected or unsuspected , contingent or non-contingent, whether concealed or hidden, which now exist, or heretofore have existed, upon any theory of law or equity now existing or coming into existence in the future , including but not limited to, conduct which is negligent, intentional, with or without malice, or a breach of any duty, law or rule, without regard to the subsequent discovery or existence of such different or additional facts. Class Representatives and Defendants acknowledge, and Class Members by operation of law shall be deemed to have acknowledged, that the inclusion of "Unknown 13 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Claims Document 163 Filed 05/17/2007 Page 14 of 33 in the definition of Settled Claims and Settled Defendants' Claims was separately bargained for and was a key element of the Settlement. The Settlement Consideration 2. The Settlement Amount consists of the total consideration to be paid by the Insurers on behalf of Defendants and equals TEN MILLION DOLLARS ($ 10,000,000.00). Under no circumstances will the Defendants be obligated to pay any portion of the Settlement Amount. Within (1) the later of thirty calendar days of execution of the Stipulation or ten days of the Court' s preliminary approval of the Settlement and (2) no sooner than thirty days after receipt of wire transfer instructions, including account name, account number, tax identification number for the putative class entity, executed W-9 Form on behalf of the putative class, bank name, ABA routing number, and SWIFT number, the Defendants shall cause the Underwriters of Lloyd' s, London ("Lloyds ) to deposit its contribution toward the Settlement Amount (the "First Deposit ) into an interest-bearing escrow account in the name "In re: Biopure Corporation Securities Litigation Settlement Fund, with a tax identification number to be provided by Plaintiffs, with Robert A. Buhlman, Esq., Counsel to the Defendants, and Edward F. Haber, Esq. and Howard T. Longman, Esq., Counsel to the Class Representatives, serving as joint account holders, all of whose express authority is required for any account activity (the "Initial Escrow Account ). The amount of the First Deposit shall be the remaining limits of the Lloyds policy covering the Defendants for the Action. 3. Within (1) the later of thirty calendar days of the execution of the Stipulation or ten days of the Court's preliminary approval of the Settlement and (2) no sooner than thirty days after receipt of wire transfer instructions, including account name, account number, tax identification number for the putative class entity, executed W-9 Form on behalf of the putative class, bank name, ABA routing number, and SWIFT number, the Defendants shall cause Old 14 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 15 of 33 Republic Insurance Company ("Old Republic ) to deposit its contribution toward the Settlement Amount (the "Second Deposit ) into the Initial Escrow Account. The amount of the Second Deposit shall be FIVE MILLION DOLLARS ($ 5,000 , 000.). 4. Within (1) the later of thirty calendar days of the execution of the Stipulation or ten days of the Court's preliminary approval of the settlement and (2) no sooner than thirty days after receipt of wire transfer instructions, including account name, account number, tax identification number for the putative class entity, executed W-9 Form on behalf of the putative class, bank name, ABA routing number, and SWIFT number, the Defendants shall cause Carolina Casualty Insurance Company ("Carolina Casualty ) to deposit its contribution toward the Settlement Amount (the "Third Deposit ) into the Initial Escrow Account. The amount of the Third Deposit shall be the total required which when added to the First Deposit and the Second Deposit equals exactly TEN MILLION DOLLARS ($ 10,000 , 000.). 5. If the Effective Date as defined in ¶27 does not occur because Defendants do not cause the First Deposit, Second Deposit and Third Deposit to be deposited in conformity with ¶12-4, the Class Representatives through Co-Lead Counsel shall have the right, but not the obligation, to terminate this Stipulation pursuant to ¶28. The Initial Escrow Account will require signatures of Co-Lead Counsel Edward F. Haber and Howard T. Longman and Defendants' Counsel Robert A. Buhlman to release deposited funds prior to the Effective Date. In the event final approval of the Settlement is not obtained from or granted by the Court for any reason or in the event an appeal of final judgment is filed and the final judgment is vacated or remanded, or in the event the Settlement is terminated, then all monies in the Initial Escrow Account shall be wire-transferred or otherwise delivered back to Lloyds, Old Republic and Carolina Casualty to include (i) the full amount of their respective Deposits; (ii) less any amounts paid or owed as 15 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 16 of 33 reasonable costs and expenses associated with the Settlement as of that time; (iii) plus their pro rata portion of interest accrued, if any, and any portion of the Settlement Amount previously caused to be paid by Defendants, together with any interest earned thereon, within ten (10) business days of said termination. Otherwise, all interest accruing on the Initial Escrow Account shall accrue to the benefit of the Class. Within three business days after the Effective Date , all monies in the Initial 6. Escrow Account shall be wire transferred to an escrow account designated by Co-Lead Counsel (the "Escrow Account ), with Co-Lead Counsel serving as sole escrow agents (the "Escrow Agents ). All interest accruing on both Escrow Accounts shall accrue to the benefit of the Class. (a) The Settlement Amount and any interest earned thereon shall be the Gross Settlement Fund. The Gross Settlement Fund, net of any Taxes (as defined below) on the 7. income thereof, shall be used to pay (i) the notice and administration costs referred to in ¶11 hereof, (ii) escrow fees; (iii) the attorneys' fee and expense award referred to in ¶12 hereof; and (iv) any award to Class Representatives granted by the Court referred to in ¶12 hereof. The balance of the Gross Settlement Fund after the above payments shall be the Net Settlement Fund, which shall be distributed to the Authorized Claimants as provided in this Stipulation and the Plan of Allocation. (b) Any sums required to be held in the Initial Escrow Account and Escrow Account shall be deemed to be in the custody of the Court and shall remain subject to the jurisdiction of the Court until such time as the funds shall be distributed or returned to the persons paying the same pursuant to this Stipulation and/or further order of the Court. Any funds in excess of one-hundred thousand dollars ($100,000) shall be invested in short term 16 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 17 of 33 United States Agency or Treasury Securities (or a mutual fund invested solely in such instruments), and shall collect and reinvest all interest accrued thereon. Any funds held in escrow in an amount of less than $100,000 may be held in an interest-bearing bank account insured by the FDIC. The parties hereto agree that the Gross Settlement Fund is intended to be a Qualified Settlement Fund within the meaning of Treasury Regulation § 1.468B-1 and elect to have such Qualified Settlement Fund treatment apply as of the earliest possible date. The Escrow Agents, as administrator of the Gross Settlement Fund held in the Escrow Account within the meaning of Treasury Regulation § 1.468B-2(k)(3), shall be responsible for filing tax returns for the Gross Settlement Fund and paying from the Gross Settlement Fund any Taxes owed with respect to the Gross Settlement Fund. Biopure agrees to provide to the Escrow Agents the statement described in Treasury Regulation § 1.468B- 3(e) no later than February 15 of the year following the calendar year in which the Insurers make a transfer of the Settlement Amount. (c) All (i) taxes on the income of the Gross Settlement Fund and (ii) expenses and costs incurred in connection with the taxation of the Gross Settlement Fund (including, without limitation, expenses of tax attorneys and accountants) (collectively "Taxes ) shall be paid out of the Gross Settlement Fund, shall be considered to be a cost of administration of the Settlement and shall be timely paid by Escrow Agents without prior order of the Court. In no event shall the Defendants or the Released Parties have any responsibility for or liability with respect to the Taxes. Scope and Effect of Settlement; Releases 8. (a) The obligations incurred pursuant to this Stipulation shall be in full and final disposition of the Action as against the Defendants and any and all Settled Claims as against all Released Parties and any and all Defendants' Settled Claims. 17 ACTIVE/72007843.1 Case 1:03-cv-12628-NG (b) Document 163 Filed 05/17/2007 Page 18 of 33 For purposes of this Settlement, the Parties stipulate to the certification of the Class as defined in ¶1(d) above. 9. (a) Upon the Effective Date of this Settlement, Class Representatives and members of the Class (other than Class Members who have timely requested to be excluded from the Class) on behalf of themselves, their heirs, executors, administrators, successors and assigns, shall be deemed to have, and by operation of the Judgment shall have, with respect to each and every Settled Claim, fully, finally and forever released, relinquished, and discharged, and shall forever be enjoined from prosecuting, either directly or in any other capacity, any Settled Claims against any of the Released Parties and their attorneys, whether or not such Class member executes and delivers a Proof of Claim and Release form. By entering this Stipulation, Class Representatives represent and warrant that they have not assigned, hypothecated, transferred, or otherwise granted any interest in the Settled Claims, or any of them, to any other party or entity. (b) Upon the Effective Date of this Settlement, each of the Defendants, on behalf of themselves and the Released Parties, shall release and forever discharge the Class Members, the Class Representatives and their attorneys from each and every of the Settled Defendants' Claims, and shall forever be enjoined from prosecuting the Defendants' Settled Claims against the Class Members , the Class Representatives and their attorneys. Administration 10. Co-Lead Counsel may designate the settlement Claims Administrator, subject to Court approval. Defendants' Counsel shall cooperate in the administration of the Settlement to the extent reasonably necessary to effectuate its terms, including directing its transfer agent or agents to provide all available information from Biopure's transfer records concerning the identity of Class Members and their transactions during the Class Period. Biopure shall direct its transfer agent or agents to provide the shareholder lists for the Class Period to Co-Lead Counsel 18 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 19 of 33 within fourteen (14) calendar days of the Courts' execution of the Preliminary Approval Order. Biopure or its transfer agent or agents shall also provide a list of Persons who are excluded from the Class pursuant to the definition set forth in ¶1(d). 11. Co-Lead Counsel may pay from the Gross Settlement Fund up to one-hundred thousand dollars ($100,000) without further approval from the Defendants or the Court except for Mr. Robert A. Buhlman's signature pursuant to Paragraph 5, for the reasonable costs and expenses associated with identifying members of the Class and effecting mailed Notice and Summary Notice to the Class, and the administration of the Settlement, including without limitation, the actual costs of publishing the Summary Notice, printing and mailing the Notice, engaging third party services to identify or update the mailing addresses of Class members, reimbursements to nominee owners for forwarding notice to their beneficial owners, and the administrative expenses incurred and fees charged by the Claims Administrator in connection with providing notice and processing the submitted claims, when these costs are incurred. In the event final approval is not obtained or granted for any reason, any and all funds so expended shall not be owed to or recoverable by the Defendants, Lloyds, Old Republic or Carolina Casualty. Attorneys' Fees and Expenses 12. Co-Lead Counsel will apply to the court for: (a) an award on behalf of Co-Lead Counsel from the Gross Settlement Fund of attorneys' fees and reimbursement of expenses, plus interest on such amounts; and (b) a compensatory award on behalf of Class Representatives, which if awarded, will be paid from the Gross Settlement Fund when the Order and Final Judgment becomes Final. Such amounts of attorneys' fees and reimbursement of expenses, plus interest on such amounts, as are awarded by the Court shall be payable from the Gross Settlement Fund when the Order and Final Judgment becomes Final. The award of attorneys' 19 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 20 of 33 fees shall be allocated among Co-Lead Counsel in a fashion which, in the opinion of Co-Lead Counsel, fairly compensates Co-Lead Counsel for their respective contributions in the prosecution of the Action. Any order or proceedings related to the fees or expenses or interest thereon, application, or any appeal from any order relating thereto or reversal or modification thereof, shall not modify, terminate, or cancel this Stipulation, or affect or delay the finality of the Order and Final Judgment approving the Stipulation and the Settlement of the Action. Defendants and the Released Parties shall have no responsibility for or liability with respect to any payment of attorneys' fees and expenses to Co-Lead Counsel separate and apart from the Gross Settlement Fund. Distribution to Authorized Claimants 13. Any member of the Class who does not submit a valid Proof of Claim will not be entitled to receive any of the proceeds from the Net Settlement Fund, but will otherwise be bound by all of the terms of this Stipulation and the Settlement, including the terms of the Order and Final Judgment to be entered in the Action and the releases provided for herein, and will be barred from asserting any Settled Claim against any of the Released Parties, as provided herein. 14. The Claims Administrator shall process the Proofs of Claim and, after entry of an order for class distribution (the "Class Distribution Order ), distribute the Net Settlement Fund to the Authorized Claimants. Co-Lead Counsel shall have the right, but not the obligation, to direct the Claims Administrator to waive what they deem to be formal or technical defects in any Proofs of Claim submitted in the interests of achieving substantial justice. 15. For purposes of determining the extent, if any, to which a Class Member shall be entitled to be treated as an "Authorized Claimant, the following conditions shall apply: (a) Each Class Member shall be required to submit a Proof of Claim (see attached Exhibit 2 to Exhibit A), supported by such documents as are designated therein, 20 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 21 of 33 including proof of the transactions claimed and the losses incurred thereon, or such other documents or proof as the Claims Administrator, in its discretion, under the direction of Co-Lead Counsel, may deem acceptable; (b) All Proofs of Claim must be submitted by the date specified in the Notice unless such period is extended by order of the Court. Any Class Member who fails to submit a Proof of Claim by such date shall be forever barred from receiving any payment pursuant to this Stipulation (unless, by order of the Court, a later submitted Proof of Claim by such Class Member is approved), but shall in all other respects be bound by all of the terms of this Stipulation and the Settlement, including the terms of the Order and Final Judgment to be entered in the Action and the releases provided for herein, and will be barred from bringing any action against the Released Parties asserting the Settled Claims. Provided that it is received before the motion for the Class Distribution Order is filed, a Proof of Claim shall be deemed to have been submitted when posted, if received with a postmark indicated on the envelope and if mailed by first-class mail and addressed in accordance with the instructions thereon. In all other cases, the Proof of Claim shall be deemed to have been submitted when actually received by the Claims Administrator; (c) Each Proof of Claim shall be submitted to and reviewed by the Claims Administrator, who shall determine in accordance with this Stipulation and the direction given by Co-Lead Counsel the extent, if any, to which each claim shall be allowed, subject to review by the Court pursuant to subparagraph (e) below; (d) Proofs of Claim that do not meet the submission requirements may be rejected. Prior to rejection of a Proof of Claim, the Claims Administrator shall communicate with the Claimant in order to remedy the curable deficiencies in the Proof of Claim submitted. 21 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 22 of 33 The Claims Administrator shall notify, in a timely fashion and in writing, all Claimants whose Proofs of Claim they propose to reject in whole or in part, setting forth the reasons therefor, and shall indicate in such notice that the Claimant whose claim is to be rejected has the right to a review by the Court if the Claimant so desires and complies with the requirements of subparagraph (e) below; (e) If any Claimant whose claim has been rejected in whole or in part desires to contest such rejection, the Claimant must, within twenty (20) days after the date of mailing of the notice required in subparagraph (d) above, serve upon the Claims Administrator a notice and statement of reasons indicating the Claimant's grounds for contesting the rejection along with any supporting documentation , and requesting a review thereof by the Court. If a dispute concerning a claim cannot be otherwise resolved by the Claims Administrator, Co-Lead Counsel and the Claimant, Co-Lead Counsel shall thereafter present the request for review to the Court; and (f) The administrative determinations of the Claims Administrator accepting and rejecting claims, after review by Co-Lead Counsel, shall be presented to the Court, on notice to Defendants ' Counsel , for approval by the Court in the Class Distribution Order. (g) All proceedings with respect to the administration, processing and determination of claims described by ¶ 15(a) - 15(f) of this Stipulation and the determination of all controversies relating thereto, including disputed questions of law and fact with respect to the validity of claims , shall be subject to the jurisdiction of the Court. 16. Each Claimant shall be deemed to have submitted to the jurisdiction of the Court with respect to the Claimant' s claim. All proceedings with respect to the administration, processing and determination of claims described in ¶15 of this Stipulation and the determination 22 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 23 of 33 of all controversies relating thereto, including disputed questions of law and fact with respect to the validity of claims, shall be subject to the jurisdiction of the Court. No discovery shall be allowed on the merits of the Action or Settlement in connection with the processing of Proofs of Claim. 17. Payment pursuant to this Stipulation shall be deemed final and conclusive against all Class Members. All Class Members whose claims are not approved by the Court shall be barred from participating in distributions from the Net Settlement Fund, but otherwise shall be bound by all the terms of this Stipulation and the Settlement, including the terms of the Order and Final Judgment to be entered in the Action and the releases provided for herein, and will be barred from bringing any action against the Released Parties concerning the Settled Claims. 18. The Net Settlement Fund shall be distributed to Authorized Claimants by the Claims Administrator only after the Effective Date and after: (i) all claims have been processed, and all Claimants whose claims have been rejected or disallowed, in whole or in part, have been notified and provided the opportunity to be heard concerning such rejection or disallowance; (ii) all objections with respect to all rejected or disallowed claims have been resolved by the Court, and all appeals therefrom have been resolved or the time therefor has expired; (iii) all matters with respect to attorneys' fees , costs , compensatory awards, and disbursements have been resolved by the Court, all appeals therefrom have been resolved or the time therefor has expired; (iv) all costs of administration, including those set forth in ¶11, have been paid, and (v) all attorneys' fees and expenses, as described in ¶12, have been paid. 19. Co-Lead Counsel will apply to the Court, on notice to Defendants' Counsel, for the Class Distribution Order approving the Claims Administrator's administrative determinations concerning the acceptance and rejection of the claims submitted herein and approving any fees 23 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 24 of 33 and expenses not previously applied for, including any fees and expenses of the Claims Administrator that require such application, and, if the Effective Date has occurred, directing payment of the Net Settlement Fund to Authorized Claimants. 20. By the determination of the Claims Administrator, each Authorized Claimant shall be allocated a pro rata share of the Net Settlement Fund based on his or her accepted claim compared to the total accepted claims of all accepted Claimants, as defined in the Plan of Allocation described in the Notice annexed hereto as Exhibit 1 to Exhibit A, or in such other Plan of Allocation as the Court approves. Defendants shall have no involvement in reviewing or challenging claims. 21. The Plan of Allocation proposed in the Notice is not a necessary term of this Stipulation, and it is not a condition of this Stipulation that any particular Plan of Allocation be approved. It is understood and agreed by the Parties hereto that the proposed Plan of Allocation is not part of the Stipulation and is to be considered by the Court separately from the Court's consideration of the fairness, reasonableness and adequacy of the Settlement set forth in the Stipulation, and any order or proceeding relating to the Plan of Allocation shall not operate to terminate or cancel the Stipulation or affect the finality of the Court's Order and Final Judgment approving the Stipulation and the Settlement set forth herein, or any other orders entered pursuant to the Stipulation. 22. No person shall have any claim against any of the Class Representatives, Class Members, Co-Lead Counsel, the Claims Administrator, the Defendants or their counsel based on the Claims Administrator' s decisions as to acceptance or rejection of Proofs of Claims or based on investments or distributions made substantially in accordance with this Stipulation and the Settlement contained herein, the Plan of Allocation or further orders of the Court. 24 ACTIVE/72007843.1 Case 1:03-cv-12628-NG 23. Document 163 Filed 05/17/2007 Page 25 of 33 The Defendants and Defendants' Counsel shall have no responsibility for, interest in, or liability whatsoever with respect to: (a) any act, omission or determination of the Escrow Agent, Claims Administrator, Co-Lead Counsel or any designees or agents of Co-Lead Counsel, Escrow Agent or Claims Administrator; (b) any act, omission or determination of Co-Lead Counsel or their designees or agents in connection with the administration of the Settlement; (c) the management, investment or distribution of the Gross Settlement Fund after it is transferred to the Escrow Account; (d) the determination, administration , calculation or payment of any claims asserted against the Gross Settlement Fund; or (e) the Plan of Allocation. Terms of the Preliminary Approval Order 24. Promptly after execution of this Stipulation and concurrently with their application for preliminary court approval of the Settlement contemplated by this Stipulation, Co-Lead Counsel and Defendants' Counsel shall jointly move the Court for entry of a Preliminary Approval Order, substantially in the form annexed hereto as Exhibit A. Terms of Order and Final Judgment 25. If the Settlement contemplated by this Stipulation is approved by the Court, counsel for the Parties shall request that the Court enter an Order and Final Judgment substantially in the form annexed hereto as Exhibit B. 25 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 26 of 33 Supplemental Agreement 26. Simultaneously herewith, Co-Lead Counsel and Defendants' Counsel are executing a "Supplemental Agreement setting forth certain conditions under which this Stipulation may be terminated by Defendants, if potential Class Members purchased or acquired above a certain threshold number of the outstanding shares of Biopure common stock during the Class Period opt out of the Class. The Supplemental Agreement shall not be filed with the Court unless a dispute arises as to its terms. In the event Defendants terminate this Stipulation pursuant to the Supplemental Agreement, this Stipulation shall become null and void and of no further force and effect and the provisions of ¶28 shall apply. Notwithstanding the foregoing, the Stipulation shall not become null and void as a result of the election by Defendants to exercise their option to terminate the Stipulation pursuant to the Supplemental Agreement until the conditions set forth in the Supplemental Agreement have been satisfied. Effective Date of Settlement, Waiver or Termination 27. The Effective Date of Settlement shall be the date when all the following shall have occurred: (a) entry of the Preliminary Approval Order in all material respects in the form annexed hereto as Exhibit A; (b) Defendants have caused the Settlement Amount to be deposited pursuant (c) approval by the Court of the Settlement, following notice to the Class, as to ¶¶2-4; prescribed by Rule 23 of the Federal Rules of Civil Procedure; and (d) entry by the Court of an Order and Final Judgment, substantially in the form attached hereto as Exhibit B, and the expiration of any time for appeal or review of such Order and Final Judgment, or, if any appeal is filed and not dismissed, after such Order and Final 26 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 27 of 33 Judgment is upheld on appeal in all material respects and is no longer subject to review upon appeal or review by writ of certiorari, or, in the event that the court enters an Alternative Judgment and none of the Parties hereto elects to terminate this Settlement, the date that such Alternative Judgment becomes final and no longer subject to appeal or review. 28. (a) Defendants or Class Representatives through Co-Lead Counsel shall have the right, but not the obligation, to terminate the Settlement and this Stipulation by providing written notice of their election to do so ("Termination Notice ) to all other Parties hereto within thirty (30) business days of: (a) the Court 's declining to enter the Preliminary Approval Order in any material respect; (b) the Court's refusal to approve this Stipulation or any material part of it; (c) the Court's declining to enter the Order and Final Judgment in any material respect; (d) the date upon which an order of the Court of Appeals, modifying the Order and Final Judgment in any material respect, becomes final; (e) the date upon which an order of the Supreme Court; modifying the Order and Final Judgment in any material respect, becomes final; (f) the date upon which an order of the Court of Appeals, modifying in any material respect, an Alternative Judgment (in the event that none of the Parties had elected to terminate the Settlement because of the Alternative Judgment), becomes final ; (g) the date upon which an order of the Supreme Court, modifying the Alternative Judgment (in the event that none of the Parties had elected to terminate the Settlement because of the Alternative Judgment) in any material respect, becomes final. (b) The Class Representatives, through Co-Lead Counsel, shall have the right, but not the obligation, to terminate the Settlement and this Stipulation by providing written notice of their election to do so ("Termination Notice ) to all other Parties hereto within thirty (30) business days of.-the Settlement Amount not having been paid pursuant to ¶12-4; 27 ACTIVE/72007843.1 Case 1:03-cv-12628-NG 29. Document 163 Filed 05/17/2007 Page 28 of 33 Except as otherwise provided herein, in the event the Settlement is terminated or fails to become effective for any reason, then the Parties to this Stipulation shall be deemed to have reverted to their respective status in the Action as of the date and time immediately prior to the execution of this Stipulation. If the Settlement is terminated or fails to become effective, except as otherwise expressly provided, the Parties shall proceed in all respects as if this Stipulation and any related orders had not been entered and within ten (10) days thereafter shall file with the Court a status report. No Admission of Wron2doin2 30. The Parties agree that the Settlement Amount, as well as the other terms of the Settlement, were negotiated in good faith by the Parties and reflect a settlement that was reached voluntarily after consultation with experienced legal counsel. Neither the Stipulation nor the Settlement contained therein, nor any act performed or document executed pursuant to or in furtherance of the Stipulation or the Settlement: (a) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives; (b) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives in any civil, criminal or administrative proceeding in any court, administrative agency or other tribunal; (c) is or may be deemed as an admission or concession that the consideration to be given hereunder represents the amount which could be or would have been recovered after trial; or (d) is or may be construed as or received as evidence as an admission, concession or presumption against Lead Plaintiff or any of the Class Members that any of their claims are without merit, or that any defenses by the Defendants have merit, or that damages recoverable under the SCAC would not have exceeded the Gross Settlement Fund. The Released Parties may file the Stipulation and/or 28 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 29 of 33 the Final Order and Judgment of this Action in any other action that may be brought against them in order to support a defense or counterclaim based on principles of res judicata, collateral estoppel , release , good faith settlement , judgment bar or reduction or any theory of claim preclusion or issue preclusion or similar defense or counterclaim. The Defendants have denied and continue to deny each and every claim alleged against them in the Action and any wrongdoing whatsoever and this Stipulation shall in no event be construed or deemed to be evidence of or an admission or concession on the part of any Defendant with respect to any claim of any fault, liability, wrongdoing or damage whatsoever, or any infirmity in the defenses that the Defendants have asserted. Miscellaneous Provisions 31. All of the exhibits attached hereto are hereby incorporated by reference as though fully set forth herein. 32. If a case is commenced with respect to any of the Defendants or the Insurers under Title 11 of the Bankruptcy Code, or a trustee, receiver or conservator is appointed under any similar law, and in the event of the entry of a final order of a court of competent jurisdiction determining the transfer of money to the Gross Settlement Fund or any portion thereof to be a preference, voidable transfer, fraudulent transfer or similar transaction and any portion thereof is required to be returned, and such amount is not promptly deposited to the Gross Settlement Fund by others, then, at the election of Co-Lead Counsel, the Parties shall jointly move the Court to vacate and set aside the releases given and Order and Final Judgment entered in favor of the Defendants pursuant to this Stipulation, which releases and Order and Final Judgment shall be null and void, and the Parties shall be restored to their respective positions in the Action as of the date a day prior to the date of this Stipulation and any cash amounts in the Gross Settlement Fund shall be returned as provided in ¶29 above. 29 ACTIVE/72007843.1 Case 1:03-cv-12628-NG 33. Document 163 Filed 05/17/2007 Page 30 of 33 The Parties to this Stipulation intend the Settlement to be a final and complete resolution of all disputes asserted or which could have been asserted by the Class Representatives, the Class or their attorneys against the Released Parties with respect to the Settled Claims. Defendants will not deny that the litigation is being settled voluntarily after consultation with competent legal counsel. Class Representatives, Defendants, and their counsel shall not make any applications for fees, costs or sanctions, pursuant to Rule 11, Rule 37, Rule 45, or any other court rule or statute, with respect to any claims or defenses in this Action or to any aspect of the institution, prosecution or defense of this Action. The Parties are aware of no facts or circumstances that would give rise to any violations of Rule 11 of the Federal Rules of Civil Procedure relating to this Action. The final judgment will contain a statement that each side shall bear its own costs unless otherwise specified herein. The Parties agree that the amount paid and the other terms of the Settlement were negotiated at arm's-length in good faith by the Parties, and reflect a settlement that was reached voluntarily after consultation with experienced legal counsel. 34. This Stipulation may not be modified or amended, nor may any of its provisions be waived except by a writing signed by all Parties hereto or their successors-in-interest. 35. The headings herein are used for the purpose of convenience only and are not meant to have legal effect. 36. The administration and consummation of the Settlement as embodied in this Stipulation shall be under the authority of the Court, and the Court shall retain jurisdiction for the purpose of entering orders providing for awards of attorneys' fees and expenses to Co-Lead Counsel, compensatory awards to Class Representatives, and enforcing the terms of this Stipulation. 30 ACTIVE/72007843.1 Case 1:03-cv-12628-NG 37. Document 163 Filed 05/17/2007 Page 31 of 33 The waiver by one Party of any breach of this Stipulation by any other Party shall not be deemed a waiver of any other prior or subsequent breach of this Stipulation. 38. This Stipulation, its exhibits, and the Supplemental Agreement constitute the entire agreement among the Parties hereto concerning the Settlement of the Action, and no representations , warranties or inducements have been made by any Party hereto concerning this Stipulation and its exhibits other than those contained and memorialized in such documents. 39. This Stipulation may be executed in one or more counterparts. All executed counterparts and each of them shall be deemed to be one and the same instrument provided that counsel for the Parties to this Stipulation shall exchange among themselves original signed counterparts. 40. This Stipulation shall be binding upon, and inure to the benefit of, the successors and assigns of the Parties hereto. 41. The construction, interpretation, operation, effect and validity of this Stipulation, and all documents necessary to effectuate it, shall be governed by the internal laws of the Commonwealth of Massachusetts without regard to conflicts of laws, except to the extent that federal law requires that federal law governs. 42. This Stipulation shall not be construed more strictly against one Party than another merely by virtue of the fact that it, or any part of it, may have been prepared by counsel for one of the Parties, it being recognized that it is the result of arm's-length negotiations between the Parties and all Parties have contributed substantially and materially to the preparation of this Stipulation. 43. All counsel and any other person executing this Stipulation and any of the exhibits hereto, or any related settlement documents, warrant and represent that they have the full 31 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 32 of 33 authority to do so and that they have the authority to take appropriate action required or permitted to be taken pursuant to the Stipulation to effectuate its terms. 44. Co-Lead Counsel and Defendants' Counsel agree to cooperate fully with one another in seeking this Court's approval of the Preliminary Approval Order, the Stipulation and the Settlement and entry of the Order and Final Judgment and to promptly agree upon and execute all such other documentation as may be reasonably required to obtain final approval by the Court of the Settlement. Dated : May 17, 2007 Dated: May 17, 2007 /s/ Edward F. Haber Edward F. Haber, Esq. Matthew L. Tuccillo, Esq. Shapiro Haber & Urmy LLP 53 State Street Boston, MA 02109 Tel: (617) 439-3939 Fax: (617) 439-0134 Counsel for Plaintiffs /s/ Howard T. Longman Howard T. Longman, Esq. Stull, Stull & Brody 6 East 45th Street New York, NY 10017 Tel: (212) 687-7230 Fax: (212) 490-2202 Counsel for Plaintiffs Dated : May 17, 2007 /s/ Robert A. Buhlman Robert A. Buhlman, Esq. Michael D. Blanchard, Esq. Bingham McCutchen LLP 150 Federal Street Boston, MA 02110 Tel: (617) 951-8000 Fax: (617) 951-8736 Counsel for Defendants 32 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163 Filed 05/17/2007 Page 33 of 33 Certificate of Service I hereby certify that this document, filed through the ECF system, will be sent electronically to the registered participants as identified on the Notice of Electronic Filing ("NEF ) and paper copies will be sent to those indicated as non-registered participants on the 17th day of May, 2007. /s/ Edward F. Haber Edward F. Haber 33 ACTIVE/72007843.1 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 1 of 9 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION Civ. No. 03-12628-NG PROPOSED ORDER OF PRELIMINARY APPROVAL WHEREAS, the parties to the above-described class action ("Action") have applied for an order, pursuant to Rule 23(e) of the Federal Rules of Civil Procedure , fixing certain matters in connection with a proposed settlement of the Action (the "Proposed Settlement "), in accordance with a Stipulation And Agreement of Settlement ("Settlement Agreement") entered into by the parties as of May 17, 2007 together with the exhibits annexed thereto , which are incorporated herein by reference; NOW, THEREFORE , pursuant to Rule 23(e) of the Federal Rules of Civil Procedure, upon the agreement of the parties, and after consideration of the Settlement Agreement and the exhibits annexed thereto, IT IS HEREBY ORDERED that: 1. The provisions of the Settlement Agreement, including definitions of the terms used therein, are hereby incorporated by reference as though fully set forth herein. 2. The parties' Proposed Settlement, as embodied in the Settlement Agreement and the exhibits attached thereto, is preliminarily approved as fair, reasonable, adequate and in the best interests of the Class, pending a final hearing on the Proposed Settlement as provided herein. 1 ACTIVE/2674295.1 Case 1:03-cv-12628-NG 3. Document 163-2 Filed 05/17/2007 Page 2 of 9 This Proposed Settlement shall apply to the Class, preliminarily certified by the Court for purposes of effectuating the Proposed Settlement, as defined in the Settlement Agreement and consisting of all persons or entities who purchased or otherwise acquired of Biopure Corporation ("Biopure") common stock from April 9, 2003 through December 24, 2003, inclusive ("Class Period"). Excluded from the Class are Defendants in this action, the former and current officers and directors of Biopure, members of their immediate families and their legal representatives, heirs, successors or assigns and any entity in which Defendants have or had a controlling interest. 4. The Court approves, as to form and content, the proposed form of Notice of Proposed Settlement of Class Action, Motion for Attorneys' Fees and Settlement Fairness Hearing submitted by the parties as Exhibit A-I to the Settlement Agreement ("Notice"), and the Proof of Claim Form submitted by the parties as Exhibit A-2 to the Settlement Agreement ("Proof of Claim"), and directs that Co-Lead Counsel for the Class shall mail, or cause to be mailed, such Notice and Proof of Claim to all members of the Class who can be identified through reasonable effort. The mailing is to be made by first-class United States mail, postage prepaid, at least 60 days prior to the date of the Settlement Hearing. Within fourteen (14) business days from the date of entry of this order, Biopure shall direct its transfer agent(s) to provide to the Claims Administrator a list containing the identity of all record holders of Biopure common stock who purchased their common stock during the Class Period. 5. Nominees who purchased or otherwise acquired Biopure common stock during the Class Period are directed to: (a) send the Notice and the Proof of Claim Form to all beneficial owners of Biopure common stock purchased or otherwise acquired during the Class Period, 2 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 3 of 9 within ten (10) days after receipt of the Notice; or (b) send a list of the names and addresses of such beneficial owners to the Claims Administrator within ten (10) days after receipt of the Notice. 6. The Court hereby approves , as to form and content , the proposed form of Summary Notice of Settlement submitted by the parties as Exhibit A-3 to the Settlement Agreement ("Summary Notice"), and directs that Co-Lead Counsel for the Class shall cause such Summary Notice to be published once in the national edition of The Wall Street Journal no more than 10 days after the mailing of the Notice and at least 50 days prior to the Settlement Hearing. 7. The Court finds and determines that mailing of the Notice and Proof of Claim and the publication of the Summary Notice as set forth above constitute the best notice to the Class practicable under the circumstances, constitute due and sufficient notice of the matters set forth in said Notice and Summary Notice to all persons entitled to receive such notice, and fully satisfy the requirements of due process, of 15 U.S.C. § 78u-4(a)(7), and of Rule 23 of the Federal Rules of Civil Procedure. 8. Any Class Member who desires to request exclusion from the Class must submit a written request for exclusion in the form and manner required by the Notice. Such request for exclusion must be mailed with a postmark no later than , 2007 (fourteen (14) calendar days prior to the Settlement Fairness Hearing date); must refer to the action In re: Biopure Corporation Securities Litigation, No. 03-12628-NG; must include a statement that the Class Member wishes to be excluded from the Class; must provide the number of shares of Biopure common stock that Class Member owned as of April 8, 2003 and the number of shares 3 ACTIVE/2674295.1 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 4 of 9 of Biopure common stock that Class Member purchased and sold during the Class Period, and the dates of such purchases and sales. Such requests for exclusion must be mailed to: In re Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 9. Any Class Member who does not properly and timely request exclusion shall be included in the Class and shall be bound by any deter ination, order or judgment entered in the Action in connection with the Settlement, whether favorable or unfavorable, even if such Class Member does not submit a timely Proof of Claim. 10. A hearing will be held by this Court in the courtroom of the Honorable Nancy Gertner, United States District Court, One Courthouse Way, Boston, Massachusetts 02210 at _.m. on , 2007 ("Settlement Fairness Hearing"), to determine: (a) whether the Proposed Settlement should be approved as fair, reasonable, adequate, and in the best interests of the Class; (b) whether an Order and Final Judgment should be entered substantially in the form of Exhibit B to the Settlement Agreement; (c) whether the Class should be finally certified; (d) whether the Class Representatives' proposed plan of allocation of the Settlement proceeds that is described in the Notice ("Plan of Allocation ") should be approved as fair and reasonable to the Class; and (e) whether the application of Co-Lead Counsel for the Class for an award of attorneys' fees, costs, and expenses, including an award of reasonable costs and expenses to the Class Representatives, ("Fee and Expense Petition") should be approved. The Settlement Hearing is subject to continuation or adjournment by the Court without further notice. 4 Case 1:03-cv-12628-NG 11. Document 163-2 Filed 05/17/2007 Page 5 of 9 Prior to the Settlement Hearing, Co-Lead Counsel for the Class shall cause an affidavit to be filed with the Court certifying that the Notice has been provided and the Summary Notice has been published as directed in Paragraphs 3, 4 and 5 of this Order. 12. Attendance at the Settlement Hearing is not mandatory. Notwithstanding, any Class Member who does not timely and properly exclude him/her/itself from the Class may appear and show cause at the Settlement Hearing in person or by counsel and be heard in support of, or in opposition to, the fairness, reasonableness and adequacy of the Proposed Settlement, the Plan of Allocation and/or the Fee and Expense Petition submitted by Co-Lead Counsel for the Class. However, no Class Member shall be heard in opposition. to the Proposed Settlement and no paper or brief submitted by any such person shall be received or considered by the Court unless fourteen (14) calendar days before the Settlement Hearing, that person shall file with the Clerk of this Court and serve copies on counsel at the following addresses a written statement of the position he, she or it will assert , and the reasons for his, her or its position, and proof of membership in the Class: Clerk United States District Court District of Massachusetts One Courthouse Way Boston, MA 02110 Howard T. Longman, Esq. Stull, Stull & Brody 6 East 45th Street New York, NY 10017 Edward F. Haber, Esq. Shapiro Haber & Urmy LLP Exchange Place 53 State Street Boston, MA 02109 5 ACTIVE/2674295.1 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 6 of 9 Plaintiffs' Co-Lead Counsel Robert A. Buhlman, Esq. Bingham McCutchen LLP 150 Federal Street Boston, MA 02110 Counsel for Defendants Any person who fails to object in the manner and by the date required shall be deemed to have waived any objections, and shall be forever barred from raising any objection to the terms and conditions of, or to the fairness, reasonableness or adequacy of the Proposed Settlement or to the Judgment to be entered thereon in this or any other action or proceeding. 13. In order to share in any proceeds resulting from the settlement of this Action, Class Members must submit the Proof of Claim in the manner provided in Exhibit A-2 of the Settlement Agreement by no later than October 31, 2007. Provided they are received before the motion for Class Distribution Order is filed, all Proofs of Claim received by the Claims Administrator shall be deemed to have been submitted when posted, if received with a postmark indicated on the envelope and if mailed by first-class mail and addressed in accordance with the instructions in the Notice. Late claims shall be denied as untimely except as the Court may otherwise order. 14. Any Class Member may enter an appearance in the Action, at his, her or its own expense, individually or through counsel of his, her or its choice. If any Class Member does not enter an appearance, he, she or it will be represented by Co-Lead Counsel for the Class. 15. Subject to the terms of the Stipulation, Co-Lead Counsel may use up to $100,000.00 (One Hundred Thousand Dollars) of the Gross Settlement Fund to pay costs and 6 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 7 of 9 expenses reasonably and actually incurred in connection with the administration of the Settlement, including without limitation identifying and providing notice to the Class, locating Class Members, processing Proofs of Claim, assisting with the filing of claims, administering and distributing the Gross Settlement Fund to the Members of the Class, and paying escrow fees and costs, if any. Pursuant to 1J5 of the Stipulation and Agreement of Settlement, Co-Lead Counsel must obtain Mr. Robert A. Buhhnan's signature to release deposited funds from the Initial Escrow Account prior to the Effective Date of Settlement. No such amounts shall be used to pay the attorneys' fees of Co-Lead Counsel. In the event final approval is not attained or granted for any reason, any and all funds so expended shall not be owed to or recoverable by the Defendants or the Defendants' insurers, as provided by the terms of Paragraph 5 of the Stipulation. 16. All discovery and pretrial proceedings in this Action are stayed and suspended until further order of this Court. Pending the final determination of the fairness, reasonableness and adequacy of the Proposed Settlement, no member of the Class, either directly, representatively, or in any other capacity, shall institute, commence or prosecute against the Defendants any of the Settled Claims in any action or proceeding in any court or tribunal. 17. All funds held by the Escrow Agent shall be deemed and considered to be in the custody of the Court, and shall remain subject to the jurisdiction of the Court, until such time as such funds shall be distributed pursuant to the Settlement Agreement and/or further order(s) of the Court. 7 ACTIVE/2674295.1 Case 1:03-cv-12628-NG 18. Document 163-2 Filed 05/17/2007 Page 8 of 9 All papers in support of the Proposed Settlement, including any application by Co-Lead Counsel for the Class for attorneys' fees and expenses shall be filed and served at least five (5) business days before the Settlement Hearing. 19. Neither the Settlement Agreement, nor any act performed or document executed pursuant to or in furtherance of the Stipulation or the Settlement: (a) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives; (b) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives in any civil, criminal or administrative proceeding in any court, administrative agency or other tribunal; (c) is or may be deemed as an admission or concession that the consideration to be given hereunder represents the amount which could be or would have been recovered after trial; or (d) is or may be construed as or received as evidence as an admission, concession or presumption against Lead Plaintiff or any of the Class Members that any of their claims are without merit, or that any defenses by the Defendants have merit, or that damages recoverable under the SCAC would not have exceeded the Gross Settlement Fund. The Released Parties may file the Stipulation and/or the Final Order and Judgment of this Action in any other action that may be brought against them in order to support a defense or counterclaim based on principles of resjudicata, collateral estoppel, release, good faith settlement, judgment bar or reduction or any theory of claim preclusion or issue preclusion or similar defense or counterclaim. The Defendants have denied and continue to deny each and every claim alleged against them. in the Action and any wrongdoing whatsoever and the Settlement Agreement shall in no event be construed or deemed to be evidence of or an admission or concession on the part of any 8 Case 1:03-cv-12628-NG Document 163-2 Filed 05/17/2007 Page 9 of 9 Defendant with respect to any claim of any fault, liability, wrongdoing or damage whatsoever, or any infirmity in the defenses that the Defendants have asserted. 20. The Court reserves the right to adjourn or continue the Settlement Hearing, and any adjournment or continuance may be without further notice of any kind other than oral announcement at the Settlement Hearing or at any later hearing. Date: .2007. The Honorable Nancy Gertner United States District Judge 9 ACTIVE/2674295.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 1 of 25 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION ) CIVIL ACTION NO. 03- 12628-NG NOTICE OF PROPOSED SETTLEMENT OF CLASS ACTION, MOTION FOR ATTORNEYS' FEES AND SETTLEMENT FAIRNESS HEARING ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 2 of 25 TO: ALL PERSONS OR ENTITIES WHO PURCHASED OR OTHERWISE ACQUIRED COMMON STOCK OF BIOPURE CORPORATION (" BIOPURE "), DURING THE PERIOD FROM APRIL 9, 2003 THROUGH DECEMBER 24, 2003, INCLUSIVE. PLEASE READ THIS NOTICE CAREFULLY AND IN ITS ENTIRETY. YOUR RIGHTS WILL BE AFFECTED BY PROCEEDINGS IN THIS ACTION. IF YOU ARE A CLASS MEMBER, YOU MAY BE ENTITLED TO RECEIVE BENEFITS BY FILING A PROOF OF CLAIM FORM. PLEASE NOTE THAT IF YOU HAVE ANY OTHER CLAIMS AGAINST DEFENDANTS OR BIOPURE, YOU MAY BE DEEMED TO RELEASE SUCH CLAIMS IF YOU REMAIN A MEMBER OF THE CLASS, EVEN IF YOU DO NOT FILE A PROOF OF CLAIM FORM. PLEASE SEE SECTION VII BELOW FOR DETAILS. DEADLINE FOR FILING CLAIMS : If you are a member of the Class as defined below and wish to participate in the settlement, you must submit to the Claims Administrator a Proof of Claim and Release Form ("Proof of Claim ), on the form accompanying this notice, postmarked no later than October 31, 2007. DEADLINE FOR REQUESTING EXCLUSION FROM THE CLASS : Requests for exclusion from the Class must be sent to the Claims Administrator, as described below, postmarked no later than BANKS, SECURITIES BROKERS, AND OTHER NOMINEES : Please see Instructions in Section IX below. YOU ARE HEREBY NOTIFIED, as a member of a proposed Class, that the parties have agreed that this lawsuit should proceed as a class action for purposes of settlement only. The "Class consists of all persons or entities who purchased or otherwise acquired common stock of Biopure Corporation ("Biopure ), during the period from April 9, 2003 through December 24, 2003, inclusive (the "Class Period ). Excluded from the Class are Defendants, present or former Officers and Directors of Biopure, members of their immediate families and their legal representatives , heirs, successors , or assigns , and any entity in which Defendants have, or had, a controlling interest. YOU ARE HEREBY NOTIFIED, pursuant to Rule 23 of the Federal Rules of Civil Procedure, and a 2007 Order of the United States District Court for the District of 2 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 3 of 25 Massachusetts (the "Court ), that pursuant to the Stipulation and Agreement of Settlement (the "Stipulation ) dated as of May 17, 2007 and filed with the Court, a settlement (the "Settlement ) of the above-captioned action (the "Action ) in the amount of $10 million (Ten Million Dollars) in cash has been reached with all Defendants in the Action, including Biopure, Thomas A. Moore, Carl W. Rausch, Ronald F. Richards, Howard P. Richman, Charles A. Sanders and J. Richard Crout (collectively "Defendants ). The Settlement is subject to approval by the Court. If approved, the Settlement will result in, among other things: (1) the payment of the Settlement Amount, as defined below and after certain deductions described below, to eligible members of the Class who file timely and valid Proof of Claim forms and evidence a recognized loss; and (2) the dismissal of the above-referenced Action and the release of the Released Claims, as described in the Stipulation and in the Proof of Claim form, as against the Defendants and certain related persons and entities. YOU ARE FURTHER NOTIFIED, pursuant to the Court's 2007 Order, that a hearing (the "Settlement Hearing ) shall be held before the Honorable Nancy Gertner, located in Courtroom 2, John Joseph Moakley U. S. Courthouse, 1 Courthouse Way, Boston, Massachusetts 02210, on , 2007 at a.m./p.m., to consider : (1) whether to certify a class for settlement purposes only; (2) whether the Settlement described above should be approved by the Court as fair, reasonable and adequate; (3) whether this Action should be dismissed on the merits with prejudice and judgment should be entered releasing claims against the Defendants, as set forth in the Stipulation; (4) whether the proposed Plan of Allocation (described in Section VI(B) of this Notice) should be approved; (5) whether the Court should approve the application of Co-Lead Counsel for the class for payment of attorneys' fees and reimbursement of costs and expenses; and (6) whether the Court should award reasonable costs ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 4 of 25 and expenses to the Lead Plaintiff Ronald Erickson and Plaintiff Dr. John G. Esposito, Jr. (the "Class Representatives ) incurred in connection with this Action. 1. SUMMARY OF NOTICE This Notice is not intended to be, and should not be, construed as an expression of any opinion by the Court with respect to the truth of the allegations in the Action or the merits of the claims or defenses asserted or the fairness or adequacy of the Settlement. This Notice is intended only to advise you of the pendency and Settlement of the Action and of your rights in connection with the Settlement. A. Statement of Plaintiffs' Recovery Pursuant to the Settlement described herein, the Settlement Amount of $10 million (Ten Million Dollars) is being held in escrow and is currently earning interest for the benefit of the Class . The Settlement Amount, plus interest earned thereon, is referred to in this Notice as the "Settlement Fund. The Class Representatives estimate that there were approximately 29,574,000 shares of Biopure common stock purchased and/or acquired during the Class Period, which were damaged as a result of the alleged acts or omissions described below. Based on that estimate, the Class Representatives estimate that the average recovery per damaged share under the Settlement will be approximately $0.34 per share before the deduction of attorneys' fees, costs and expenses, as approved by the Court. An individual Class Member may receive more or less than this average amount per share, depending on the number of claims filed, when the shares were purchased during the Class Period and, if sold, when they were sold, and the amounts awarded by the Court for attorneys' fees, costs and expenses. B. Parties' Positions and Reasons for Settlement 4 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 5 of 25 The Class Representatives believe that the claims asserted in the Action have merit and that the evidence developed to date supports the claims asserted. Defendants have denied and continue to deny each and all of the claims and contentions alleged by the Class Representatives in the Action and do not believe any evidence supports those claims and contentions. However, Class Representatives and Defendants recognize and acknowledge the inherent difficulties, expense, and length of continued proceedings necessary to see the Action through trial and possible appeals , and both have determined that the Settlement as set forth in the Stipulation is in the best interests of all parties involved. C. Potential Outcome of the Case In addition to disagreeing about the potential for proving the liability of Defendants, the parties disagree on the average amount of damages per share that would be recoverable even if the Class Representatives prevailed on each claim alleged. The determination of damages is a complicated and uncertain process, typically involving conflicting expert opinions. Factors which would be considered in the determination of damages include, among others, (i) whether any of the alleged misrepresentations caused the price of Biopure stock to be artificially inflated during the Class Period, (ii) whether the disclosure of truths regarding any alleged misrepresentations was related to the drop in the price of Biopure stock during or after the Class Period, (iii) the appropriate economic model for determining the amount by which Biopure stock was artificially inflated (if at all) during the Class Period, (iv) the effect of various market forces influencing the trading price of Biopure stock at various times during the Class Period, and (v) the extent to which external factors, such as general market and industry conditions, influenced the trading price of Biopure stock during the Class Period. D. Statement of Attorneys ' Fees and Costs Sought 5 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 6 of 25 Co-Lead Counsel, as identified in Section E below, intend to apply for an award of attorneys' fees in an amount up to 33 1/3% of the Settlement Fund, as well as reimbursement for costs and expenses incurred in the prosecution of the Action of approximately $175,000. CoLead Counsel also intend to apply to the Court for the reimbursement of reasonable expenses from the Settlement Fund to the Class Representatives to the extent permissible by law, in an amount not to exceed $15,000(Fifteen Thousand Dollars) in the aggregate. The fees and expenses of the Class Representatives and Co-Lead Counsel, if granted, would be, on average, approximately $0.12 (Twelve Cents) per share of Biopure common stock, which was purchased and/or acquired during the Class Period and was damaged as a result of the alleged acts or omissions described below share. E. Identification of the Class Representatives' Counsel The Class Representatives and the Class have been represented in this Action by the following Co-Lead Counsel for the Class Representatives and the Class: Howard T. Longman, Esq. Stull, Stull & Brody 6 East 45th Street New York, NY 10017 Tel: (212) 687-7230 Edward F. Haber, Esq. Matthew L. Tuccillo, Esq. Shapiro Haber & Urmy LLP 53 State Street Boston, MA 02109 Tel: (617) 439-3939 Any questions regarding the Settlement should be directed to Co-Lead Counsel. II. DEFINITIONS As used in this Notice, the following terms shall have the following meanings, which are set forth in the Stipulation of Settlement: 6 ACTIVE/72007889.1 Case 1:03-cv-12628-NG (a) Document 163-3 Filed 05/17/2007 Page 7 of 25 "Authorized Claimant means any Class Member who submits a timely and valid Proof of Claim and Release form ("Proof of Claim ) that is accepted by the Claims Administrator. (b) "Claimant means any Class Member who files a Proof of Claim. (c) "Claims Administrator means Berdon Claims Administration LLC, which shall administer the Settlement. (d) "Class and "Class Members mean all persons or entities who purchased or otherwise acquired Biopure common stock from April 9, 2003 through December 24, 2003, inclusive. Excluded from the Class are Defendants, the former and current officers and directors of Biopure, members of their immediate families and their legal representatives, heirs, successors or assigns and any entity in which Defendants have or had a controlling interest. (e) "Class Period means the period of time from April 9, 2003 through December 24, 2003, inclusive. (f) "Court means the United States District Court for the District of Massachusetts, the Honorable Nancy Gertner presiding. (g) "Defendants means Biopure Corporation, Thomas A. Moore, Carl W. Rausch, Ronald F. Richards, Howard P. Richman, Charles A. Sanders and J. Richard Crout. (h) "Defendants' Counsel means the law firm of Bingham McCutchen, LLP. (i) "Effective Date of Settlement or "Effective Date means the date upon which the Settlement contemplated by this Stipulation shall become effective, as set forth in ¶27 below. 0) "Escrow Agents means Co-Lead Counsel, Edward F. Haber and Howard Longman. 7 ACTIVE/72007889.1 Case 1:03-cv-12628-NG (k) Document 163-3 Filed 05/17/2007 Page 8 of 25 "Final means: (i) if an appeal is filed, the date of final affirmance on an appeal from the Order and Final Judgment, the expiration of the time for a petition for a writ of certiorari to review the Order and Final Judgment or, if certiorari is granted, the date of final affirmance of the Order and Final Judgment following review pursuant to that grant; or (ii) the date of final dismissal of any appeal from the Order and Final Judgment and the final dismissal of any proceeding on certiorari to review the Order and Final Judgment; or (iii) if no appeal is filed, the expiration date of the time for the filing or noticing of any appeal from the Order and Final Judgment, i.e., thirty (30) calendar days after entry of the Order and Final Judgment (or, if the date for taking an appeal or seeking review shall be extended beyond this time by order of the Court, by operation of law or otherwise, or if such extension is requested, the date of expiration of any extension if any appeal or review is not sought); or (iv) if the Court enters an Order and Final Judgment in a form other than that provided above ("Alternative Judgment ) and none of the Parties hereto elect to terminate the Settlement, the date that such Alternative Judgment becomes final as defined in parts (i) to (iii) above and no longer subject to appeal or review. Any proceeding or order, or any appeal or petition for a writ of certiorari pertaining solely to any plan of allocation and/or application for attorneys' fees, costs or expenses, or compensatory award for Class Representatives shall not in any way delay or preclude the Order and Final Judgment from becoming final. (1) "Gross Settlement Fund means the Settlement Amount, plus any interest earned thereon. (m) "Insurers means the Underwriters of Lloyd's, London; Old Republic Insurance Company; and Carolina Casualty Insurance Company (the "Insurers ). 8 ACTIVE/72007889.1 Case 1:03-cv-12628-NG (n) Document 163-3 Filed 05/17/2007 Page 9 of 25 "Class Representatives means Lead Plaintiff Ronald Erickson and Plaintiff John G. Esposito. (o) "Co-Lead Counsel means Stull , Stull & Brody and Shapiro Haber & Urmy, LLP. (p) "Net Settlement Fund means the Gross Settlement Fund, as defined herein, net of any taxes, as referred to in ¶7, on the income thereof, and net of any funds to pay (i) the notice and administrative costs referred to in ¶11, (ii) taxes and escrow fees; (iii) the attorneys' fees and expense award referred to in ¶12; and (iv) any award to Class Representatives granted by the Court referred to in ¶12. (q) "Notice means the Notice of Proposed Settlement of Class Action, Motion for Attorneys' Fees and Settlement Fairness Hearing, which is to be sent to members of the Class substantially in the form attached hereto as Exhibit 1 to Exhibit A. (r) "Order and Final Judgment means the proposed order to be entered approving the Settlement substantially in the form attached hereto as Exhibit B. (s) "Person means an individual, corporation (including all divisions and subsidiaries), partnership, limited partnership, association, joint stock company, estate, legal representative, trust, unincorporated association, government or any political subdivision or agency thereof, and any business or legal entity and their spouses, heirs, predecessors, successors, representatives or assigns. (t) "Plan of Allocation means a plan or formula for the allocation of the Net Settlement Fund whereby the Net Settlement Fund shall be distributed to Authorized Claimants. (u) "Preliminary Approval Order means the proposed order preliminarily approving the Settlement and directing notice thereof to the Class substantially in the form attached hereto as Exhibit A. 9 ACTIVE/72007889.1 Case 1:03-cv-12628-NG (v) Document 163-3 Filed 05/17/2007 Page 10 of 25 "Released Parties is defined in the Stipulation of Settlement and in the accompanying Proof of Claim. (w) "Settled Claim(s) is defined in the Stipulation of Settlement and in the accompanying Proof of Claim. (x) "Defendants' Settled Claims is defined in the Stipulation of Settlement and in the accompanying Proof of Claim. (y) "Settlement Amount means the consideration to be paid by the Insurers on behalf of the Defendants pursuant to the Settlement set forth herein, which consideration shall be TEN MILLION DOLLARS ($ 10,000,000.00 ) total, consisting of the First Deposit (as defined in the Stipulation of Settlement), the Second Deposit (as defined in the Stipulation of Settlement), and the Third Deposit (as defined in the Stipulation of Settlement). (z) "Summary Notice means the Summary Notice of Settlement of Class Action for publication substantially in the form attached as Exhibit 3 to Exhibit A to the Stipulation. (aa) "Unknown Claims is defined in the Stipulation of Settlement and in the accompanying Proof of Claim. III. COMMENCEMENT OF THE ACTION AND NATURE OF THE ACTION A. Procedural History On or after December 30, 2003, fifteen securities fund class actions were filed in the United States District Court for the District of Massachusetts against Biopure and certain of Biopure's present or former officers . On May 14, 2004, the Court ordered these actions to be consolidated into a single action under the caption In re Biopure Securities Litigation , Civ. No. 03-12628-NG (the "Action ). The Court also appointed Ronald Erickson as Lead Plaintiff and 10 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 11 of 25 approved Erickson ' s choice of Stull, Stull & Brody and Shapiro Haber & Urmy LLP as Co-Lead Counsel. On July 23, 2004, the Class Representatives and other named Plaintiffs filed a Consolidated Amended Class Action Complaint ("CAC ) alleging violations of Section 10b of the Securities Exchange Act of 1934 (the "Exchange Act ), Rule 10b-5 promulgated thereunder, Section 20(a) of the Exchange Act, and Section 20A of the Exchange Act. On October 6, 2004, all Defendants filed a motion to dismiss the CAC. On January 5, 2006 the Plaintiffs filed a motion for leave to file a Second Consolidated Amended Complaint ("SCAC ) that raised the same legal claims as were set forth in the CAC but supported them with additional factual allegations . On March 28, 2006, the Court issued a Memorandum and Order denying the Defendants' motion to dismiss and granting the Plaintiffs leave to file the SCAC. On June 5, 2006, the Class Representatives filed an amended motion for class certification. The amended motion for class certification was pending when the Parties notified the Court that they had reached a settlement. IV. INVESTIGATION, DISCOVERY AND RESEARCH A. Investigation, Discovery and Research Conducted by Co-Lead Counsel Co-Lead Counsel conducted extensive discovery and factual investigation during their prosecution of the Action, including, inter alia, (1) review and analysis of Biopure's public filings with the Securities and Exchange Commission ("SEC ), annual reports, and other public statements ; (2) review of transcripts of testimony in a related proceeding brought by the SEC; (3) consultations with experts; (4) research of the applicable law with respect to the claims asserted in the Action and the potential defenses thereto; (5) detailed review and analysis of over 40,000 pages of documents produced by Defendants in discovery. 11 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 12 of 25 Based upon their investigation to date , Co-Lead Counsel believe that the causes of action asserted in the SCAC have merit and that the evidence developed to date supports their claims. V. CLAIMS OF PLAINTIFFS AND BENEFITS OF SETTLEMENT Co-Lead Counsel and Class Representatives believe that the terms and conditions of this Stipulation are fair, reasonable and adequate to the Class Representatives and the Class Members, and in their best interests. The Class Representatives have agreed to settle the claims raised in the Action pursuant to the terms and provisions of this Stipulation, after considering: (1) the substantial benefits that Class Representatives and the Class Members will receive from the Settlement; (2) the attendant risks of litigation; and (3) the desirability of permitting the Settlement to be consummated as provided by the terms of this Stipulation. Co-Lead Counsel and Class Representatives recognize and acknowledge the expense and length of time which would be consumed by continued proceedings necessary to prosecute the Action against the Defendants through trial and appeals . Co-Lead Counsel and Class Representatives have also taken into account the uncertain outcome and the risk of any litigation, especially in complex actions such as this Action, as well as the difficulties and delays inherent in such litigation . Co-Lead Counsel and Class Representatives are also mindful of the inherent problems of proof under, and possible defenses to, the securities law violations asserted in the Action. Further, Co-Lead Counsel and Class Representatives also considered the ability to pay issues arising from the financial circumstances of Biopure and the ability to fund a settlement or satisfy a verdict from limited insurance proceeds, which have been used in part to defend this Action and a related action prosecuted by the SEC. In light of the foregoing, Co-Lead Counsel and Class Representatives believe that the Settlement confers substantial benefits upon the Class 12 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 13 of 25 and have determined that the Settlement as set forth in the Stipulation is in the best interests of the Class Representatives and the Class Members. VI. THE DEFENDANTS' STATEMENT AND DENIALS OF WRONGDOING AND LIABILITY Defendants have denied and continue to deny each and all of the claims and contentions alleged by the Class Representatives in the Action. Defendants expressly have denied and continue to deny all charges of wrongdoing or liability against them arising out of any conduct, statements , acts or omissions alleged, or that could have been alleged, in the Action. Defendants have also denied and continue to deny, inter alia, the allegations that Class Representatives or the Class have suffered damages, that the price of Biopure common stock was artificially inflated by reasons of alleged misrepresentations, non-disclosures or otherwise, and that the Class Representatives or the Class were harmed by the conduct alleged in the SCAC. Nonetheless, Defendants have concluded that further conduct of the Action would be protracted and expensive, have taken into account the uncertainty and risks inherent in any litigation (especially in complex securities cases like this Action) and have concluded that it is desirable that the Action and any Settled Claims, including Unknown Claims (as defined in the Stipulation), be fully and finally settled in the manner and upon the terms and conditions set forth in the Stipulation. VII. THE PROPOSED SETTLEMENT The following description of the Settlement is only a summary, and reference is made to the text of the Stipulation, on file with the Court, for a full statement of its provisions: A. The Settlement Fund consists of the principal amount of $10 million (Ten Million Dollars) in cash, plus interest. 13 ACTIVE/72007889.1 Case 1 : 03-cv-12628 - NG B. Document 163-3 Filed 05/17/2007 Page 14 of 25 Upon approval of the Settlement by the Court, and when the Judgment has become final and all other conditions to the Settlement are satisfied, the Settlement Fund shall be distributed as follows: (1) To pay all the costs and expenses reasonably and actually incurred in administering the Settlement; (2) To pay Co-Lead Counsels' fees, expenses and costs as awarded by the (3) To pay any award ordered by the Court to the Class Representatives for Court; their reasonable costs and expenses (including lost wages) directly relating to the representation of the Class; (4) To pay the taxes and tax expenses owed by the Settlement Fund; and (5) To pay to Class Members their pro rata share of the Net Settlement Fund, as defined below, pursuant to the Plan of Allocation set forth below. (6) Plan of Allocation . Subject to the approval and further Order(s) of the Court as may be necessary, the balance of the Settlement Fund after deduction of the fees and expenses described in paragraphs (1) through (4) above (the "Net Settlement Fund ), shall be distributed to Authorized Claimants pursuant to the following Plan of Allocation. ("Authorized Claimant means any Class Member who submits a timely and valid Proof of Claim that is accepted by the Claims Administrator.) (7) Each Class Member seeking a distribution from the Net Settlement Fund shall be required to timely submit a separate Proof of Claim that shall include a general release of all Released Claims, including any Unknown Claims (as defined in the Stipulation), against the Released Parties in the form set forth in the Proof of Claim accompanying this Notice, signed 14 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 15 of 25 under penalty of perjury and supported by documented proof of all purchases (or acquisitions) and sales (or dispositions) of Biopure common stock during the Class Period. (8) All Proof of Claim forms must be sent to the Claims Administrator and postmarked on or before October 31 , 2007. Unless otherwise ordered by this Court, any Class Member who fails to submit a Proof of Claim and Release within that period, or such other period as may be ordered by the Court, shall be forever barred from receiving any payments pursuant to the Stipulation, but will, in all other respects, be subject to the provisions of the Stipulation and the final Judgment entered by the Court. (9) To the extent there are sufficient funds in the Net Settlement Fund, each Authorized Claimant will receive an amount equal to the Authorized Claimant's Recognized Loss. If, however, the amount in the Net Settlement Fund is not sufficient to permit payment of the total Recognized Loss of each Authorized Claimant, then each Authorized Claimant shall be paid the percentage that each Authorized Claimant's Recognized Loss bears to the total of the Recognized Losses of all Authorized Claimants. No cash payment will be made on a claim where the potential distribution amount is ten dollars ($10.00) or less. (10) A "Recognized Loss will be calculated as follows: (a) For the shares of Biopure common stock purchased during the period from April 9, 2003 through October 30, 2003, inclusive, and: (i) sold prior to the close of trading on October 30, 2003, the Recognized Loss shall be zero; or (ii) sold during the period from October 31, 2003 through December 24, 2003, inclusive, the Recognized Loss shall be the difference between the purchase price and the sale price; or 15 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 16 of 25 (iii) held at the close of trading on December 24, 2003, the Recognized Loss shall be the difference between the purchase price and $2.43 per share (the market price at the close of trading on December 26, 2003, the first business day after the end of the Class Period). (b) For the share of Biopure common stock purchased during the period from October 31, 2003 through December 24, 2003 , inclusive, and: (i) sold prior to the close of trading on December 24, 2003, the Recognized Loss shall be zero; or (ii) held at the close of trading on December 24, 2003, the Recognized Loss shall be the difference between the purchase price and $2.43 per share (the market price at the close of trading on December 26, 2003, the first business day after the end of the Class Period). (c) The date of purchase or sale is the "contract or "trade date and not the "settlement date. (d) All profits will be subtracted from all losses to determine the net Recognized Loss of each Authorized Claimant. Brokerage commissions, fees and taxes should be included in the purchase and sale prices of Biopure shares. (e) In processing claims , the first-in, first-out basis ("FIFO ) will be applied to both purchases and sales. Sales will be matched in chronological order, by trade date, first against the securities held as of the close of trading on April 8, 2003 (the last day before the Class Period begins) and then against the purchases during the Class Period. 16 ACTIVE/72007889.1 Case 1 : 03-cv-12628 - NG (f) Document 163-3 Filed 05/17/2007 Page 17 of 25 The date of covering a "short sale is deemed to be the date of purchase of Biopure shares. The date of a "short sale is deemed to be the date of sale of Biopure shares. Shares originally sold short prior to the Class Period shall have zero Recognized Loss. (g) Where securities were purchased/sold by reason of having exercised an option, the option premium should be incorporated into the price accordingly. (h) YOUR CLAIM WILL NOT BE VALID IF YOU DID NOT SUFFER A RECOGNIZED LOSS. (i) The Court has reserved jurisdiction to allow, disallow or adjust the Claim of any Class Member on equitable grounds. (11) Although the Net Settlement Fund is being allocated among the Class Members based on the formulas stated above (subject to Court approval), it should not be assumed that an Authorized Claimant's Claim is equal to the amount of damages , if any, which could have been recovered had this Action been fully tried instead of settled. The amount of damages which Plaintiffs could prove, if any, is a matter of serious dispute, and the Settlement's use of the formula set forth above does not constitute a concession, finding or admission that liability exists or that any damages could be proven or that provable damages, if any, would be commensurate with a Claim. The Settlement avoids the risks to the Class Members that liability or damages might not have been proven at trial. (12) Distributions will be made to Authorized Claimants after all claims have been processed and after the Court has finally approved the Settlement. If any funds remain in the Net Settlement Fund by reason of un-cashed checks or otherwise, then, after the Claims Administrator has made reasonable and diligent efforts to have Class members who are entitled to participate in the distribution of the Net Settlement Fund cash their distributions, any balance 17 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 18 of 25 remaining in the Net Settlement Fund one (1) year after the initial distribution of such funds shall be re-distributed to Class members who have cashed their initial distributions and who would receive at least ten dollars ($10.00) pro rata from such re-distribution, after payment of any unpaid costs or fees incurred in administering the Net Settlement Fund for such re-distribution. If after six (6) months after such re-distribution, any funds shall remain in the Net Settlement Fund, then such balance shall be contributed to non-sectarian, not-for-profit, 501(c)(3) organization(s) designated by Class Co-Lead Counsel. (13) All Class Members who fail to complete and file a valid and timely Proof of Claim shall be barred from participating in distributions from the Net Settlement Fund, unless they submit a valid exclusion request pursuant to Section X below or unless otherwise ordered by the Court, but otherwise shall be bound by the Settlement and by all of the terms of the Stipulation, including the terms of the Order and Final Judgment or of any judgment entered by the Court. (14) No person shall have any claim against Plaintiffs' Counsel, the Claims Administrator or other agent designated by Plaintiffs' Counsel, or any Defendant or any Defendant's counsel based on the distribution made substantially in accordance with the Stipulation and this Plan of Allocation, or further orders of the Court. VIII. DISMISSAL AND RELEASES If the Settlement is approved by the Court, the Court will enter a final judgment which will: A. Dismiss the Action in its entirety as against the Defendants with prejudice and without costs to any party as against any other party; adjudge that the Class Representatives and each Class Member, except those who both timely and validly request exclusion in accordance 18 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 19 of 25 with the procedures detailed herein, shall be deemed conclusively to have released the Released Claims and Unknown Claims (described in the Release accompanying the Proof of Claim and in the Stipulation) against the Released Parties. Notwithstanding that the Class Representatives, or one or more Class Members, may hereafter discover facts in addition to, or different from, those which the Class Representatives or Class Members now know or believe to be true with respect to the Action and Released Claims or to the subject matter of the Action, which, if known, might have affected his, her, or its settlement with, and release of, the Released Parties, or might have affected his, her or its decision not to object to the Settlement, each of the Class Representatives and Class Members shall be deemed, upon the date of the final judgment for this Action, to have fully, finally and forever settled and released, as against any of the Released Parties, and all Released Claims and Unknown Claims, that have been, or might have been, asserted by the Class Representatives or Class Members, or any of them, against Defendants, or any of them, based upon, or related to, the purchase or acquisition of Biopure common stock by the Class Representatives or Class Members during the Class Period, and the facts, transactions, events , occurrences , acts or omissions which were, or could have been, alleged in the Action. B. Bar and permanently enjoin each of the Class Representatives and the Class Members from prosecuting the Released Claims (including Unknown Claims) against the Released Parties, as set forth in the Release accompanying the Proof of Claim; C. Reserve jurisdiction, without affecting the finality of the judgment entered, over: (1) Implementation of this Settlement and any award or distribution of the Net Settlement Fund, including interest earned or accrued thereon; (2) Disposition of the Gross Settlement Fund; 19 ACTIVE/72007889.1 Case 1 : 03-cv-12628 - NG (3) Document 163-3 Filed 05/17/2007 Page 20 of 25 Hearing and determining Co-Lead Counsel's applications for attorneys' fees, costs, interest, and expenses, including fees and costs of experts and/or consultants and the award of reasonable costs and expenses (including lost wages) directly relating to the representation of the Class, to the Class Representatives; (4) Enforcing and administering the Stipulation, including any Releases executed in connection therewith; and (5) Other matters related or ancillary to any of the foregoing. As part of the Settlement, the Defendants have released and agreed not to sue the Class Representatives, Co-Lead Counsel, or any Class Member for any claims that arise out of or relate in any way to the institution, prosecution, or settlement of the Action. IX. SPECIAL NOTICE TO BANKS, BROKERS, AND OTHER NOMINEES To all banks, brokerage firms, institutions and other Persons that are nominees who purchased or otherwise acquired the common stock of Biopure for the beneficial interest of other Persons during the Class Period (April 9, 2003 through December 24, 2003, inclusive): within ten (10) days after you receive this Notice and the accompanying Proof of Claim and Release, you must either (1) provide the Claims Administrator with the names and addresses of such beneficial owners , preferably on computer-generated mailing labels or, electronically, in MS Word or WordPerfect files (label size Avery # 5162), or in an MS Excel data table setting forth (a) title/registration , (b) street address, (c) city/state/zip; or (2) send copies of the Notice and the Proof of Claim and Release to all beneficial owners by first-class mail and provide the Claims Administrator with written confirmation of having done so. Additional copies of the Notice may be requested by contacting the Claims Administrator at: In re Biopure Corporation Securities Litigation 20 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 21 of 25 c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 Telephone: (800) 766-3330 Fax: (516) 931-0810 Website: www.berdonclaims.com You are entitled to the reimbursement of any reasonable expenses actually incurred in connection with the research of records and (1) the generating of labels or electronic media or (2) the mailing of this Notice, after submission to the Claims Administrator of a written request, together with appropriate supporting documentation. X. THE RIGHTS AND OBLIGATIONS OF CLASS MEMBERS If you are a Member of the Class, you may receive the benefit of, and you will be bound by, the terms of the Settlement described in Section VI of this Notice, and recited more fully in the Stipulation, upon approval of the Settlement by the Court. If you are eligible to be a Class Member (that is, if you purchased or otherwise acquired Biopure common stock during the period of April 9, 2003 through December 24, 2003, inclusive), you have the following options: A. You may file a Proof of Claim. If you choose this option, you will remain a Class Member; you will share in the proceeds of the Settlement if the Settlement is finally approved by the Court and if your claim is timely and validly filed and supports a Recognized Loss; and you will be bound by the Judgment and Releases. B. If you do not wish to be a Class Member or be included in the Class, and you do not wish to participate in the Settlement described in this Notice, you may request to be excluded. To do so, you must state in writing that you wish to be excluded from the Settlement. Your written request for exclusion must also set forth: (1) the name of this Action: In re Biopure Corporation Securities Litigation, Case No.: 03-12628 (NG); (2) your name, address and 21 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 22 of 25 telephone number; (3) the name, address and telephone number of the record owner of Biopure Common Stock, if different from your own as the beneficial owner; (4) the number of Biopure common shares that you owned as of April 8, 2003; (5) the number of Biopure common shares that you purchased or otherwise acquired during the Class Period, including the price and the dates of those purchases or acquisitions; and (6) the number of Biopure common shares you sold during the Class Period, including the price and the dates of those sales . The written exclusion request should be sent to the Claims Administrator at: In re Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 To be considered valid, the exclusion request must be postmarked no later than , 2007. NO REQUEST FOR EXCLUSION WILL BE CONSIDERED VALID UNLESS ALL OF THE INFORMATION DESCRIBED ABOVE IS INCLUDED IN THE REQUEST. C. If you validly request exclusion from the Class : ( 1) you will be excluded from the Class; (2) you will not share in the proceeds of the Settlement described herein; (3) you will not be bound by any judgment entered in the Action; and (4) you will not be precluded by this Settlement from otherwise prosecuting an individual claim, if timely, at your own expense against Defendants, based on the matters complained of in the Action. D. If you do not request to be excluded from the Class, you will be bound by any and all determinations or judgments in the Action concerning the Settlement entered or approved by the Court, whether favorable or unfavorable to the Class Members, including, without limitation, the Judgment described above. If you do not exclude yourself from the Class, you will be deemed to have released all Claims which you may have against the Defendants, whether 22 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 23 of 25 or not you submit a Proof of Claim. If you have filed or intend to file other claims against any Defendants, you may need to request exclusion from the Class to retain such claims, and you should consult your attorney. E. If you do not request to be excluded from the Class, you may object to the Settlement, the Plan of Allocation and/or the applications of Co-Lead Counsel for an award of attorneys' fees and reimbursement of expenses in the manner set forth below. The filing of a Proof of Claim and Release by a Class Member does not preclude a Class Member from objecting to the Settlement, the Plan of Allocation, and/or the fees and expenses applied for by Co-Lead Counsel. However, if your objection is rejected, you will be bound by the Settlement and the Final Judgment just as if you had not objected. In order to object to any aspects of this settlement, you must follow the procedure set forth in Section X below. F. You may do nothing at all. If you choose this option, you will not share in the proceeds of the Settlement, but you will be bound by the Final Judgment, and you will be deemed to have released Defendants, including Biopure, just as if you had filed a Proof of Claim and Release. G. If you are a Class Member, you may, but are not required to, enter an appearance in writing through counsel of your own choosing at your own expense. If you do not do so, you will be represented by Co-Lead Counsel. XI. THE RIGHT TO BE HEARD AT THE SETTLEMENT HEARING At the Settlement Hearing, the Court will consider whether the Settlement is fair, reasonable and adequate; whether it should be approved by the Court; whether Judgment should be entered dismissing the Action on the merits and with prejudice as against Defendants; whether the proposed Plan of Allocation is fair and reasonable; and whether Co-Lead Counsel's 23 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 24 of 25 applications for attorneys' fees and reimbursement of costs and expenses should be approved. The Settlement Hearing may be adjourned, from time to time, by the Court at or prior to the Settlement Hearing, or any adjourned session thereof, without further notice. Any Member of the Class, who has not requested exclusion, may appear at the Settlement Hearing to show cause why the Settlement should or should not be approved and the Action should or should not be dismissed on the merits with prejudice, and/or to present any opposition to the Plan of Allocation or the application of Co-Lead Counsel for fees and expenses . However, no such Person shall be heard, unless the objection or statement of support is made in writing and filed, together with copies of all other papers and briefs, with the Court at Clerk of the Court, John Joseph Moakley U.S. Courthouse, 1 Courthouse Way, Suite 2300, Boston, MA 02210, no later than , 2007, and showing due proof of service on all of the following: (1) both Howard T. Longman, Esq., Stull, Stull & Brody, 6 East 45th Street, New York, NY 10017, Tel: (212) 687-7230, Fax: (212) 490-2202 and Edward F. Haber, Esq. and Matthew L. Tuccillo, Esq., Shapiro Haber & Urmy LLP, 53 State Street, Boston, MA 02109, Tel: (617) 439-3939, Fax: (617) 439-0134, Co-Lead Counsel; and (2) Robert A. Buhlman, Esq. and Michael D. Blanchard, Esq., Bingham McCutchen LLP, 150 Federal Street, Boston, MA 02110, Tel: (617) 951-8000, Fax: (617) 951-8736, Defendants'Attorneys. Any Class Member who does not make his, her or its objection or statement of support in the manner provided, shall be deemed to have waived all objections and opposition to the fairness , reasonableness and adequacy of the Settlement, to the Plan of Allocation, and to the request of Co-Lead Counsel for attorneys' fees and expenses. XII. EXAMINATION OF PAPERS AND INQUIRIES 24 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-3 Filed 05/17/2007 Page 25 of 25 For a more detailed statement of the matters involved in the Action and the Settlement thereof, reference is made to the pleadings, to the Stipulation and to other papers filed in the Action, which may be inspected at the Office of the Clerk of the United States District Court, John Joseph Moakley U.S. Courthouse, 1 Courthouse Way, Suite 2300, Boston, MA 02210, during the business hours of each business day. Inquiries regarding the submission of proofs of claim should be addressed to the Claims Administrator at: In re Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 Telephone: (800) 766-3330 Fax: (516) 931-0810 Website: www.berdonclaims.com However, communications which convey confidential information should be sent directly to Co-Lead Counsel, or to your own attorney. PLEASE DO NOT CONTACT THE COURT OR THE CLERK'S OFFICE REGARDING THIS NOTICE. Dated: , 2007 BY ORDER OF THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF MASSACHUSETTS 25 ACTIVE/72007889.1 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 1 of 14 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION ) ) CIVIL ACTION NO. 03-12628-NG PROOF OF CLAIM AND RELEASE DEADLINE FOR SUBMISSION: October 31, 2007 IF YOU PURCHASED OR OTHERWISE ACQUIRED COMMON STOCK OF BIOPURE CORPORATION ("BIOPURE ) DURING THE PERIOD FROM APRIL 9, 2003 THROUGH DECEMBER 24, 2003, INCLUSIVE (THE "CLASS PERIOD ), YOU AREA "CLASS MEMBER, AND YOU MAY BE ENTITLED TO SETTLEMENT PROCEEDS. (EXCLUDED FROM THE CLASS ARE DEFENDANTS, MEMBERS OF THEIR IMMEDIATE FAMILIES AND THEIR LEGAL REPRESENTATIVES, HEIRS, SUCCESSORS OR ASSIGNS AND ANY ENTITY IN WHICH DEFENDANTS HAVE OR HAD A CONTROLLING INTEREST.) IF YOU ARE A CLASS MEMBER, IN ORDER TO BE ELIGIBLE FOR ANY SETTLEMENT BENEFITS, YOU MUST COMPLETE AND SIGN THIS PROOF OF CLAIM AND RELEASE AND MAIL IT BY PREPAID, FIRST CLASS MAIL, POSTMARKED NO LATER THAN OCTOBER 31, 2007 TO: Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 YOUR FAILURE TO SUBMIT YOUR PROOF OF CLAIM AND RELEASE POSTMARKED BY OCTOBER 31, 2007 TO THE CLAIMS ADMINISTRATOR MAY SUBJECT YOUR CLAIM TO REJECTION AND PRECLUDE YOUR RECEIVING ANY Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 2 of 14 MONEY IN CONNECTION WITH THE SETTLEMENT OF THIS LITIGATION. DO NOT MAIL OR DELIVER YOUR CLAIM TO THE COURT OR TO ANY OF THE PARTIES OR THEIR COUNSEL, AS ANY SUCH CLAIM WILL BE DEEMED NOT TO HAVE BEEN SUBMITTED. ADMINISTRATOR. SUBMIT YOUR CLAIM ONLY TO THE CLAIMS YOU WILL BEAR ALL RISKS OF DELAY OR NON- DELIVERY OF YOUR CLAIM. Submission of this Proof of Claim and Release , however, does not assure that you will share in the proceeds of Settlement in the Litigation. If you are a Class Member, and you do not properly and timely request exclusion in connection with the Settlement, you will be bound by the terms of any judgment entered in the Litigation, WHETHER OR NOT YOU SUBMIT A PROOF OF CLAIM AND RELEASE. If you are NOT a Class Member (or legal representative of a Class Member), DO NOT submit a Proof of Claim and Release. All terms herein are as defined in the Notice ofProposed Settlement of Class Action, Motion for Attorneys' Fees and Settlement Fairness Hearing (the "Notice ) that accompanied this Proof of Claim and Release and the Stipulation and Agreement of Settlement (the "Stipulation of Settlement ) on file with the Court. CLAIM FORM INSTRUCTIONS 1. If you purchased or acquired Biopure common stock and held the certificate(s) in your name, you are the beneficial owner as well as the record owner. If, however, you purchased or acquired Biopure common stock and the certificate(s) were registered in the name of a third party, such as a nominee or brokerage firm, you are the beneficial owner and the third party is the record owner. 2. Use Part I of this form entitled "Claimant Identification to identify each beneficial owner and, if different, each record owner, of Biopure common stock that form the basis of this claim. 2 Case 1 : 03-cv-12628 - NG Document 163-4 Filed 05/17/2007 Page 3 of 14 THIS CLAIM MUST BE FILED BY THE ACTUAL BENEFICIAL OWNER OR OWNERS, OR THE LEGAL REPRESENTATIVE OF SUCH OWNER OR OWNERS, OF THE BIOPURE COMMON STOCK UPON WHICH THIS CLAIM IS BASED. 3. All joint owners must sign this claim. Executors, administrators , guardians , conservators and trustees must complete and sign this claim on behalf ofPersons represented by them, documentation establishing their authority must accompany this claim, and their titles or capacities must be stated. 4. The Social Security or Taxpayer Identification Number and telephone number of the beneficial owner may be used in verifying the claim. Failure to provide the foregoing information could delay verification of your claim or result in rejection of the claim. 5. Use Part II, §§ A, B, C and D of this form entitled " Schedule of Transactions in Biopure Common Stock to supply all required details of your transaction(s) in Biopure common stock. If you need more space, attach separate sheets giving all of the required information in substantially the same form. Print your name, Social Security or Taxpayer Identification Number, and "Proof of Claim - Schedule of Transactions in Biopure Common Stock at the top of each additional sheet. 6. On the schedules, provide all of the requested information with respect to all of your purchases and acquisitions and all of your sales of Biopure common stock that took place during the Class Period, whether such transactions resulted in a profit or a loss. Failure to report all such transactions may result in the rejection of your claim. 7. List each transaction during the Class Period separately and in chronological order, by trade date, beginning with the earliest. You must accurately provide the month, day and year of each transaction you list, as well as the number of Biopure shares involved in each transaction. 8. Brokerage commissions and transfer taxes paid by you in connection with your purchase and sale of Biopure common stock should be included in computing the "Total Cost and netted out of the "Net Proceeds. 3 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 4 of 14 9. The date of purchase or sale is the "contract or "trade date and not the "settlement date. 10. All profits will be subtracted from all losses to determine the net recognized loss of each Class Member. 11. In processing claims, the first-in, first-out basis ("FIFO ) will be applied to purchases, acquisitions and sales. Sales will be matched in chronological order by trade date, first against the common stock held as of the close of trading on April 8, 2003 (the last day before the Class Period begins) and then against the purchases/acquisitions during the Class Period. 12. The date of covering a "short sale is deemed to be the date ofpurchase of Biopure common stock. The date of a "short sale is deemed to be the date of sale of Biopure common stock. Shares originally sold short prior to the Class Period will result in a zero claim. 13. Where Biopure common stock was purchased/sold by reason of having exercised an option, the option premium should be incorporated into the price accordingly. 14. Ifan Authorized Claimants' trading activity during the Class Period exceeds 50 transactions, he, she or it must provide, in an electronic file, all purchase and sales information required in Part II, §§ A, B, C and D. For a copy of instructions and parameters concerning such a submission, contact the Claims Administrator by phone: (800) 766-3330; by fax (516) 931-0810 or via the website: www.berdonclaims.com. 15. No cash payment will be made on a claim where the potential distribution amount is $10.00 or less. 16. Copies of brokers' confirmations, monthly statements or other documentation of your transactions in Biopure common stock during the Class Period should be attached to your claim. For a complete listing ofthe documentation deemed acceptable by the Claims Administrator, please refer to the website www.berdonclaims.com. Failure to provide this documentation could delay verification of your claim or result in rejection of your claim. 4 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 5 of 14 17. All defined terms used herein, unless specifically defined herein, shall have the same meaning as set forth in the Notice and the Stipulation. Document 163-4 Filed 05/17/2007 Case 1 : 03-cv-12628 - NG UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS Page 6 of 14 In re Biopure Corporation Securities Litigation PROOF OF CLAIM B I OP U RE Must be Received by Claims Administrator Postmarked No Later Than October 31, 2007 PART I: CLAIMANT IDENTIFICATION Please Type or Print Beneficial Owner's Name (as it appears on your brokerage statement) Joint Beneficial Owner's Name (as it appears on your brokerage statement) Street Address City State Zip Code Foreign Province Foreign Country or Social Security Number Taxpayer Identification Number Specify one of the following: Individual(s) Partnership Corporation UGMA Custodian Estate Trust Other: (Day) Area Code IRA (Evening) Telephone Number Area Code Telephone Number Facsimile Number E-Mail Address Record Owner' s Name and Address (if different from beneficial owner listed above) PART II: SCHEDULE OF TRANSACTIONS IN BIOPURE COMMON STOCK 6 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 7 of 14 A. Number of shares ofBiopure common stock owned at the close of trading on April 8, 2003 (long or short) (must be documented): B. Separately list each and every purchase and/or acquisition of Biopure common stock during the period April 9, 2003 through December 24, 2003, and provide the following information (must be documented): Trade Date (list chronologically) Month/Day/Year Number of Shares Purchased Total Cost (including commissions, taxes, andfees) C. Separately list each and every sale of Biopure common stock during the period April 9, 2003 through December 24, 2003, and provide the following information (must be documented): Trade Date (list chronologically) Month/Day/Year Number of Shares Sold Net Proceeds (net of commissions, taxes, and fees) D. State the total number of shares of Biopure common stock owned at the close of trading on December 24, 2003 (must be documented): If additional space is needed, attach the required information on separate, numbered sheets in the same format, and print your name, Social Security or Taxpayer Identification Number and "Proof of Claim - Schedule of Transactions in Biopure Common Stock" at the top of each sheet. YOU MUST ALSO READ, AND SIGN THE SUBMISSION TO JURISDICTION AND RELEASE WHICH FOLLOW 7 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 8 of 14 SUBMISSION TO JURISDICTION OF COURT AND ACKNOWLEDGMENTS A. I/We submit this Proof of Claim under the terms of the Stipulation of Settlement described in the Notice. By submitting this Proof of Claim, I /we state that I/we believe in good faith that I am/we are a Class Member as defined herein and in the Notice, or I am/we are acting for such Person; that I/we have read and understand the Notice; that I/we believe that I am/we are entitled to receive a share of the Net Settlement Fund; and that I/we elect to participate in the Settlement described in the Notice. B. I/We also submit to the jurisdiction of the United States District Court for the District of Massachusetts with respect to my/our claim as a Class Member and for purposes of enforcing the release set forth herein and any judgment that may be entered in the Litigation. I/We further acknowledge that I am/we are bound by, and subject to, the terms of any judgment that may be entered in the Litigation. C. I/We hereby warrant and represent that I/we have included and have set forth where requested above all relevant information with respect to every one of my/our purchases or acquisitions and every one of my/our sales of Biopure common stock during the Class Period, as well as the number of shares of Biopure common stock owned by me/us at the close of trading on April 8, 2003 and at the close of trading on December 24, 2003 . I/We have also enclosed photocopies of the stockbroker' s confirmation slips , stockbroker' s statements , or other documents evidencing each purchase, acquisition, sale or retention of Biopure common stock listed above in support of my/our claim. [NOTE: IF ANY SUCH DOCUMENTS ARE NOT IN YOUR POSSESSION, PLEASE OBTAIN COPIES OR EQUIVALENT DOCUMENTS FROM YOUR BROKER OR PORTFOLIO MANAGER. THESE DOCUMENTS ARE NECESSARY TO PROVE AND PROCESS YOUR CLAIM.] I/We agree to furnish additional information to the Claims Administrator to support this claim if required to do so. 8 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 9 of 14 D. I/We have not submitted any other claim covering the same purchases or sales of Biopure common stock during the Class Period and know of no other Person having done so on my/our behalf. RELEASE A. I/we hereby acknowledge full and complete satisfaction of, and do hereby fully, finally and forever settle , release and discharge each and all of the Released Parties from any and all Settled Claims. As defined in the Stipulation and as used herein, the following terms shall have the following meanings: 1. "Released Parties means any and all of the Defendants, their past or present subsidiaries, parents, successors and predecessors, officers, directors, agents, employees, Insurers, co-insurers, reinsurers, controlling shareholders, attorneys, divisions, joint ventures, accountants, spouses, personal or legal representatives, assigns, heirs, any members of an Individual Defendant's immediate family and any trust of which any Individual Defendant is the settlor or which is for the benefit ofan Individual Defendant's family, and any person, firm, trust, corporation, officer, director or other individual or entity in which any Defendant has a controlling interest or which is related to or affiliated with any of the Defendants, and the legal representatives, heirs, successors in interest or assigns of any such party. 2. "Settled Claim(s) means any and all claims, including both known claims and Unknown Claims (as defined below), debts, demands, rights or causes of action or liabilities of every nature and description whatsoever (including, but not limited to, any claims for damages, interest, attorneys' fees, expert or consulting fees, equitable or injunctive relief and any other costs, expenses or liability whatsoever), whether based on federal, state, local, statutory or common law or any other law, rule or regulation, whether fixed or contingent, accrued or unaccrued, liquidated or unliquidated, at law or in equity, matured or unmatured, whether class or individual in nature, known or unknown, whether concealed or hidden, asserted or that could have been asserted, including, 9 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 10 of 14 without limitation, claims for negligence, gross negligence , breach of duty of care and/or breach of duty of loyalty, fraud, breach of fiduciary duty, or violations of any state or federal statutes, rules or regulations, (i) that have been asserted in this Action by the Class Members or their attorneys or any of them against any of the Released Parties, or (ii) that could have been asserted in any forum by the Class Members or their attorney or any ofthem or their successors and assigns or any ofthem against any of the Released Parties which arise out of or are based upon or relate in any way to the allegations, transactions, facts, matters or occurrences, representations or omissions involved, set forth, or referred to in the SCAC or relate in any way to the purchase, sale or acquisition of Biopure common stock during the Class Period except for claims to enforce the Settlement. 3. "Defendants' Settled Claims means any and all claims, debts, demands, rights or causes of action or liabilities whatsoever (including, but not limited to, any claims for damages, interest, attorneys' fees, expert or consulting fees, equitable or injunctive relief and any other costs, expenses or liability whatsoever), whether based on federal, state, local, statutory or common law or any other law, rule or regulation, whether fixed or contingent, accrued or unaccrued, liquidated or unliquidated, at law or in equity, matured or unmatured, whether class or individual in nature, including both known claims and Unknown Claims (as defined below), that have been or could have been asserted in the Action or any forum by the Defendants or any of them or the successors and assigns of any of them against any of the Class Representatives, Class Members or their attorneys, which arise out of or relate in any way to the institution, prosecution, or settlement of the Action (except for claims to enforce the Settlement). 4. "Unknown Claims means any and all claims , rights or causes of action or liabilities whatsoever, whether based on federal, state, local, statutory or common law or any other law, rule or regulation which any Lead Plaintiff or Class Member does not know or suspect to exist in his, her or its favor at the time of the release of the Released Parties, and any Defendants' Settled Claims which any Defendant does not know or suspect to exist in his, her or its favor at the time of the 10 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 11 of 14 release of the Defendants' Settled Claims, which, if known by him, her or it, could have been asserted in any forum by the Class Members or any of them against any of the Released Parties which relate to the purchase, sale or acquisition of common stock of Biopure during the Class Period, even if unknown at the time of execution of this Stipulation, or could have been asserted by the Defendants against the Lead Plaintiff or Class Members relating to the Action, even if unknown at the time of the execution of this Stipulation. With respect to any and all Settled Claims and Defendants' Settled Claims, the Parties stipulate and agree that upon the Effective Date, the Class Representatives and the Defendants shall expressly, and each Class Member shall be deemed to have, and by operation of the Order and Final Judgment shall have, expressly waived any and all provisions , rights and benefits conferred by any law of any state or territory of the United States, or principle of common law, which is similar, comparable , or equivalent to Cal. Civ. Code § 1542, which provides: A general release does not extend to claims which the creditor does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor. The Class Representatives and Class Members may hereafter discover facts in addition to or different from those which he, she or it now knows or believes to be true with respect to the subject matter of the Settled Claims, but the Class Representatives shall expressly fully, finally and forever settle and release, and each Class Member, upon the Effective Date, shall be deemed to have , and by operation of the Judgment shall have, fully, finally and forever settled and released any and all Settled Claims, known or unknown, suspected or unsuspected, contingent or non-contingent, whether concealed or hidden, which now exist, or heretofore have existed, upon any theory of law or equity now existing or coming into existence in the future , including but not limited to, conduct which is negligent, intentional, with or without malice, or a breach of any duty, law or rule, without regard to the subsequent discovery or existence of such different or 11 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 12 of 14 additional facts. Class Representatives and Defendants acknowledge, and Class Members by operation of law shall be deemed to have acknowledged, that the inclusion of "Unknown Claims in the definition of Settled Claims and Settled Defendants' Claims was separately bargained for and was a key element of the Settlement. B. This Release shall be of no force or effect unless and until the Court approves the Stipulation of Settlement and the Stipulation of Settlement becomes effective as to all Defendants and all Released Parties on the Effective Date. C. I/We hereby warrant and represent that I/we have not assigned or transferred or purported to assign or transfer, voluntarily or involuntarily, any matter released pursuant to this Release or any other part or portion thereof. D. I/We certify that I am/we are NOT subject to backup withholding under the provisions of §3406(a)(1)(c) of the Internal Revenue Code. Note: If you have been notified by the Internal Revenue Service that you are subject to backup withholding, please clearly strike out the word "NOT" in the certification above. I/We declare under penalty of perjury, under the laws of the United States of America, that the foregoing information supplied by the undersigned and the supporting documents attached hereto are true, correct and complete to the best of my/our knowledge, information and belief, and that this Proof of Claim and Release form was executed this 2007 in (City), day of (State/Country). Signature of Claimant (Print your name here) 12 Case 1 : 03-cv-12628 - NG Document 163-4 Filed 05/17/2007 Page 13 of 14 Signature of Joint Claimant, if any (Print your name here) Signature of person signing on behalf of Claimant (Print your name here) Capacity of person signing on behalf of Claimant, if other than an individual, (e.g., Executor, President, Custodian, etc.) 13 Case 1:03-cv-12628-NG Document 163-4 Filed 05/17/2007 Page 14 of 14 ACCURATE CLAIMS PROCESSING TAKES A SIGNIFICANT AMOUNT OF TIME. THANK YOU FOR YOUR PATIENCE. Reminder Checklist : 1. Please sign the above release and declaration. 2. Remember to attach only copies of acceptable supporting documentation to your claim form, a complete list of which can be found on the Claims Administrator's website. Do not send originals of common stock certificates. 4. Keep a copy of the completed claim form and supporting documentation for your records. If you desire an acknowledgment of receipt of your claim form, please send it Certified Mail, Return Receipt Requested, or its equivalent. You will bear all risks of delay or non-delivery of your claim. 6. If your address changes in the future, or if these documents were sent to an old or incorrect address, please send us written notification of your new address. 7. If you have any questions or concerns regarding your claim, please contact the Claims Administrator at: In re Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 Telephone: (800) 766-3330 Fax: (516) 931-0810 Website: www.berdonclaims.com 14 Case 1:03-cv-12628- Document 163-5 Filed 05/17/2007 Page 1 of 2 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION ) CIVIL ACTION NO. 03- 12628-NG SUMMARY NOTICE OF SETTLEMENT TO: ALL PERSONS OR ENTITIES WHO PURCHASED OR OTHERWISE ACQUIRED COMMON STOCK OF BIOPURE CORPORATION ("BIOPURE"), DURING THE PERIOD FROM APRIL 9, 2003 THROUGH DECEMBER 24, 2003, INCLUSIVE (THE "CLASS PERIOD"). IF YOU ARE A CLASS MEMBER, YOU MAY BE ENTITLED TO RECEIVE BENEFITS BY FILING A PROOF OF CLAIM FORM. PLEASE NOTE THAT IF YOU HAVE ANY OTHER CLAIMS AGAINST BIOPURE OR THE OTHER DEFENDANTS, YOU MAY BE DEEMED TO RELEASE SUCH CLAIMS IF YOU REMAIN A MEMBER OF THE CLASS, EVEN IF YOU DO NOT FILE A PROOF OF CLAIM FORM. YOU ARE HEREBY NOTIFIED, pursuant to Rule 23 of the Federal Rules of Civil Procedure, and a 2007 Order of the United States District Court for the District of Massachusetts (the "Court"), that a hearing (the "Settlement Hearing") shall be held before the Honorable Nancy Gertner, located in Courtroom 2, John Joseph Moakley U. S. Courthouse, 1 Courthouse Way, Boston, Massachusetts 02210, on , 2007 at a.m./p.m., to consider whether: (1) to certify a class for settlement purposes only consisting of all persons or entities who purchased Biopure common stock during the Class Period (the "Class"); (2) the settlement of the above-captioned action (the "Action") in the amount of $10 million (Ten Million Dollars) should be approved by the Court as fair, reasonable and adequate; (3) this Action should be dismissed on the merits with prejudice and judgment should be entered releasing claims against Biopure and the Defendants in this action; (4) the proposed plan of allocation should be approved; (5) the Court should approve the application of Co-Lead Counsel for the Class for payment of attorneys' fees and reimbursement of costs and expenses; and (6) the Court should award reasonable costs and expenses to the Class Representatives incurred in connection with this Action. If you are a Class member, in order to share in the distribution of the Settlement fund, you must submit a Proof of Claim and Release form ("Proof of Claim"), which must be received by the Claims Administrator at the address listed below or postmarked no later than October 31, 2007, establishing that you are entitled to recovery. To receive a Notice of Proposed Settlement of Class Action, Motion for Attorneys' Fees and Settlement Fairness Hearing ("Notice") and ACTIVE/72007893.1 Case 1:03-cv-12628- Document 163-5 Filed 05/17/2007 Page 2 of 2 Proof of Claim, or for further information, please write to the Claims Administrator at the following address: In re Biopure Corporation Securities Litigation c/o Berdon Claims Administration LLC P.O. Box 9014 Jericho, NY 11753-8914 Telephone: (800) 766-3330 Fax: (516) 931-0810 Website: htto://w-ww.berdonclaims.com If you purchased or otherwise acquired Biopure common stock during the Class Period , you will be deemed to be a Class Member unless you expressly request to be excluded from the Class. You must submit a valid request for exclusion to the Claims Administrator, postmarked NO LATER THAN , 2007. You will be bound by any judgment rendered in the Action unless you request to be excluded in the manner set forth in the Notice. If you submit a valid and timely request for exclusion, while you will not be entitled to share in the proceeds of this Settlement, you will not be bound by this Settlement or the Court's judgment in this Action. Co-Lead Counsel for the Plaintiffs are: Howard T. Longman, Esq. Stull, Stull & Brody 6 East 45th Street New York, NY 10017 Tel: (212) 687-7230 Edward F. Haber, Esq. Matthew L. Tuccillo, Esq. Shapiro Haber & Urmy LLP 53 State Street Boston, MA 02109 Tel: (617) 439-3939 Any questions regarding the Settlement should be directed to the Claims Administrator or to CoLead Counsel for the Plaintiffs. PLEASE DO NOT CONTACT THE COURT OR THE CLERK'S OFFICE REGARDING THIS NOTICE. Dated: .2007 BY ORDER OF THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF MASSACHUSETTS 2 ACTIVE/72007893.1 Case 1:03-cv-12628-NG Document 163-6 Filed 05/17/2007 Page 1 of 7 UNITED STATES DISTRICT COURT DISTRICT OF MASSACHUSETTS IN RE BIOPURE CORPORATION SECURITIES LITIGATION Civ. No. 03-12628-NG ORDER AND FINAL JUDGMENT WHEREAS, the parties to the above-described action (the "Action") entered into a Stipulation And Agreement of Settlement ("Settlement Agreement ) dated as of May 17, 2007 (the "Settlement"); and WHEREAS, on , 2007 the Court entered an Order of Preliminary Approval which, inter alia: (i) preliminarily approved the Settlement; (ii) confirmed that the Action has been certified as a class action, pursuant to Rules 23(a) and 23(b)(3) of the Federal Rules of Civil Procedure for purposes of settlement; (iii) approved the forms of notice of the Settlement to the Class Members; (iv) directed that appropriate notice of the Settlement be given to the Class Members; and (v) set a hearing date for final approval of the Settlement and the plan of allocation and a determination of whether the application of Co-Lead Counsel for the Class for an award of attorneys' fees, costs, and expenses, including an award of reasonable costs and expenses to the Class Representatives Plaintiffs ("Fee and Expense Petition ), should be approved; and WHEREAS, Notice of the Settlement and Proof of Claim forms were mailed to Class Members and the Summary Notice of the Settlement was published in the national edition of The Wall Street Journal, as attested to in the affidavit of the Claims Administrator filed herein; and 1 ACTIVE/2674294.1 Case 1:03-cv-12628-NG WHEREAS, on Document 163-6 Filed 05/17/2007 Page 2 of 7 , 2007, a hearing was held on whether the Settlement was fair, reasonable, adequate, and in the best interests of the Class ("Settlement Hearing"); and WHEREAS, based on the foregoing, having heard the statements of counsel for the parties and of such persons as chose to appear at the Settlement Hearing, having considered all of the pleadings and proceedings in the Action, and being otherwise fully advised, IT IS HEREBY ORDERED that: 1. The provisions of the Settlement Agreement, including definitions of the terms used therein, are hereby incorporated by reference as though fully set forth herein. 2. This Court has jurisdiction over the subject matter of the Action and over all parties to the Action, including Class Members. 3. The form, content, and method of dissemination of the notice given to the Class, including both published notice and individual notice mailed to all Class Members who could be identified through reasonable effort, was adequate and reasonable, and constituted the best notice practicable under the circumstances. 4. The notice , as given, complied with the requirements of 15 U.S.C. § 78u-4(a)(7) and of Rule 23 of the Federal Rules of Civil Procedure, satisfied the requirements of due process, and constituted due and sufficient notice of the matters set forth therein. 5. The Plan of Allocation described in the notice mailed to Class Members is fair and reasonable and it is hereby approved. 6. The Class Representatives have fairly and adequately represented the interests of the Class Members in connection with the Settlement. 7. The Class Representatives and the Class Members, and all and each of them, are hereby bound by the terms of the Settlement as set forth in the Settlement Agreement. 2 Case 1:03-cv-12628-NG 8. Document 163-6 Filed 05/17/2007 Page 3 of 7 All parties and counsel appearing herein have complied with their obligations under Rule 11(b) of the Federal Rules of Civil Procedure. 9. This action is finally certified as a class action under Rules 23(a) and (b)(3) of the Federal Rules of Civil Procedure. The Class consists of all persons or entities who, during the period from April 9, 2003 through December 24, 2003, inclusive (the "Class Period ), purchased or otherwise acquired Biopure Corporation ("Biopure ) common stock. Excluded from the Class are Defendants in this action, the former and current officers and directors of Biopure, members of their immediate families and their legal representatives, heirs, successors, or assigns and any entity in which Defendants have or had a controlling interest. 10. Excluded from the class are the persons identified in Exhibit A hereto, who have timely and properly requested exclusion from the Class. 11. The Settlement set forth in the Settlement Agreement is fair, reasonable, adequate, and in the best interests of the Class, and it shall be consummated in accordance with the terms and provisions of the Settlement Agreement. 12. Judgment shall be, and hereby is, entered dismissing the Action with prejudice and without taxation of costs in favor of or against any party except as provided in the Settlement Agreement. 13. The Class Representative Plaintiffs and all Class Members are hereby conclusively deemed to have released the Defendants, their past or present subsidiaries, parents, successors and predecessors, officers, directors, agents, employees, Insurers, co-insurers, reinsurers, controlling shareholders, attorneys, divisions, joint ventures, accountants, spouses, personal or legal representatives, assigns, heirs, any members of an Individual Defendant's immediate family and any trust of which any Individual Defendant is the settlor or which is for 3 ACTIVE/2674294.1 Case 1:03-cv-12628-NG Document 163-6 Filed 05/17/2007 Page 4 of 7 the benefit of an Individual Defendant's family, and any person, firm, trust, corporation, officer, director or other individual or entity in which any Defendant has a controlling interest or which is related to or affiliated with any of the Defendants , and the legal representatives , heirs, successors in interest or assigns of any such party (the "Released Parties ), from any and all Settled Claims. As defined in the Settlement Agreement, "Settled Claims means any and all claims, debts, demands, rights or causes of action or liabilities whatsoever (including, but not limited to, any claims for damages, interest, attorneys' fees, expert or consulting fees, equitable or injunctive relief and any other costs, expenses or liability whatsoever), whether based on federal, state, local, statutory or common law or any other law, rule or regulation, whether fixed or contingent, accrued or unaccrued, liquidated or unliquidated, at law or in equity, matured or unmatured, whether class or individual in nature, including both known claims and Unknown Claims (as defined in the Settlement Agreement): (i) that have been asserted in this Action by the Class Representatives, on their own behalf and on behalf of the Class Members or any of them against any of the Released Parties, or (ii) that could have been asserted in any forum by the Class Members or any of them against any of the Released Parties which arise out of or are based upon the allegations, transactions, facts, matters or occurrences, representations or omissions involved, set forth, or referred to in the SCAC or relate to the purchase, sale or acquisition of the common stock of Biopure during the Class Period except for claims to enforce the Settlement. 14. The Class Representatives and all Class Members are hereby barred and permanently enjoined from instituting, asserting or prosecuting, either directly, representatively, derivatively or in any other capacity, any and all Settled Claims which they or any of them had, have or may have against the Released Parties. 4 Case 1:03-cv-12628-NG 15. Document 163-6 Filed 05/17/2007 Page 5 of 7 The Plan of Allocation of the Net Settlement Fund as described in the notice to Class Members is hereby approved, subject to modification by further order of this Court. Any order or proceedings relating to the Plan of Allocation or amendments thereto shall not operate to terminate or cancel the Settlement Agreement or affect the finality of this Order approving the Settlement Agreement. 16. The Court hereby decrees that neither the Settlement Agreement nor this Final Judgment, nor the fact of the Settlement, nor any act performed or document executed pursuant to or in furtherance of the Stipulation or the Settlement: (a) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives; (b) is or may be deemed to be or may be used as an admission of, or evidence of, any fault or omission of any of the Released Parties or Class Representatives in any civil, criminal or administrative proceeding in any court, administrative agency or other tribunal; (c) is or may be deemed as an admission or concession that the consideration to be given hereunder represents the amount which could be or would have been recovered after trial; or (d) is or may be construed as or received as evidence as an admission, concession or presumption against Lead Plaintiff or any of the Class Members that any of their claims are without merit, or that any defenses by the Defendants have merit, or that damages recoverable under the SCAC would not have exceeded the Gross Settlement Fund. The Released Parties may file the Stipulation and/or the Final Order and Judgment of this Action in any other action that may be brought against them in order to support a defense or counterclaim based on principles of res judicata, collateral estoppel, release, good faith settlement, judgment bar or reduction or any theory of claim preclusion or issue preclusion or similar defense or counterclaim. The Defendants have denied and continue to deny each and every claim alleged against them in the 5 ACTIVE/2674294.1 Case 1:03-cv-12628-NG Document 163-6 Filed 05/17/2007 Page 6 of 7 Action and any wrongdoing whatsoever and this Final Judgment shall in no event be construed or deemed to be evidence of or an admission or concession on the part of any Defendant with respect to any claim of any fault, liability, wrongdoing or damage whatsoever, or any infirmity in the defenses that the Defendants have asserted. 17. The parties to the Settlement Agreement, their agents , employees , and attorneys, and the Claims Administrator and the Escrow Agent, shall not be liable for anything done or omitted in connection with these proceedings, the entry of this Final Judgment, or the administration of the payments to Authorized Claimants as provided in the Settlement Agreement and this Order, except for their own willful misconduct. No Class Member shall have any claim against the Class Representatives or Co-Lead Counsel based on distributions made substantially in accordance with the Plan of Allocation and orders of the Court. No Class Member shall have any further rights or recourse against the Defendants for any matter related to the Plan of Allocation, distributions thereunder, or the claims process generally. 18. Class Counsel are awarded attorneys' fees in the amount of $ and reimbursement of expenses, including experts' fees and expenses, in the amount of $ such amounts to be paid from out of the Gross Settlement Fund. Class Representative Plaintiff Ronald Erickson, who served as Lead Plaintiff in this Action, is awarded the sum of $ and Class Representative Plaintiff Dr. John G. Esposito, Jr. is awarded the sum of $ , as reasonable costs and expenses directly relating to the representation of the Class as provided in 15 U.S.C. § 78u-4(a)(4), such amounts to be paid from out of the Gross Settlement Fund. 6 Case 1:03-cv-12628-NG 19. Document 163-6 Filed 05/17/2007 Page 7 of 7 The attorneys' Fees and Expenses awarded herein shall be payable from the Gross Settlement Fund when the Order and Final Judgment become Final as defined in Paragraph 1(k) of the Settlement Agreement. 20. The Court hereby retains and reserves jurisdiction over implementation of this Settlement and any distribution to Authorized Claimants under the terms and conditions of the Settlement Agreement and pursuant to further orders of this Court. Date : 12007. The Honorable Nancy Gertner United States District Judge 7 ACTIVE/2674294.1