Abstract Depression as The Risk Factor for Mild Cognitive Impairment: Case Report and Discussion Rianawati, S. B. *, Harahap, H. S.** * Lecturer of Department of Neurology, Brawijaya University Faculty of Medicine, ** Resident of Department of Neurology, Brawijaya University Faculty of Medicine Mild Cognitive Impairment (MCI) is a disorder which is identified as the transition phase between cognitive decline as the part of aging process and dementia. This disorder affects cognitive functions, especially memory function. MCI can be differentiated with dementia by the characteristic of activity daily living. Patients with MCI have no difficulty in conducting activity of daily living, but patients with dementia have. Somatic, neurologic, and psychiatric disorders affecting normal brain functions can also cause MCI. One of the medical condition causing MCI is depression, even until today this relationship is still controversial. Laboratory investigations need to be conducted to eliminate other medical conditions that probably cause cognitive disorders. Although had been reported as usefull diagnostic tool to know the conversion of MCI to dementia, Brain imaging is not routinely used. Eventhough the current randomized controlled trials about the treatments are relatively minimal, some modalities of treatment which are potentially used can be applicated. This case report presented a case of patient with mild cognitive impairment with depression as the causal factor. Keywords: MCI, depression, dementia