2008
1. L.K. Mamedova, R. Wang, P. Besada, B. . Liang, K. A. Jacobson. Attenuation of
Apoptosis in vitro and Ischemia/Reperfusion Injury in vivo in Mouse Skeletal Muscle
by P2Y6 Receptor Activation. Pharmacological Research. Biochem
Pharmacol.2008;
2006
1. L.K. Mamedova, Z-G Gao and K.A. Jacobson. ADP Regulates Death and Survival
in Astrocytes by Activating P2Y1 and P2Y12 Receptors. Biochem. Pharmacol. 2006;
72:1031-1041.
2. P. Besada, L.K. Mamedova, K.K. Palaniappan, Z-G-Gao, B.V. Joshi, L.S. Jeong,
M.M. Civan, K.A. Jacobson. Nucleoside prodrugs of A3 adenosine receptor
agonists and antagonists. Col. Czechoslovak Chem. Com. 2006; 912-28.
3. N. Erkasap, M. Ikizler, V. Shneyvays, T. Zinman, L.K. Mamedova, R. Uyar, A.
Shainberg. Leptin protects the cardiac myocyte cultures from hypoxic damage. Life
sci. 2006; 78:1098-1102.
4. K.A. Jacobson, S.Costanzi, J. Bhalchandra, P. Besada, D.H. Shin, H.J. Ko, A.
Ivanov, L. Mamedova. Agonists and antagonists for P2 receptors. Purinergic
signalling in neuronglia interactions. Wiley, Chichester. Novartis Foundation
Symposium UK. 2006; 276:58-72.
5. Z.G. Gao, H.T. Duong, T. Sonin, S.K. Kim, P. Rompaey, S. Calenbergh, L.
Mamedova, L.S. Jeong, H.O. Kim, M. J. Kim, A.Y. Kim, B.T. Liang, K.A. Jacobson.
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using
tailored nucleoside agonists. J. Med. Chem. 2006; 49:2689 -2702.
2005
1. L. Mamedova, V. Capra, M.R. Accomazo, Z.G. Gao, S. Ferrario, M. Fumagalli,
M.P. Abbracchio, G.E. Rovati, K.A. Jacobson. CysLT1 leukotriene receptor
antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem.
Pharmacol. 2005; 71:115-125.
2. S. Costanzi, J. Bhalchandra, S.. Maddileti, L. Mamedova, M.J. Gonzalez-Moa, V.E.
Marquez, T.K. Harden, K.A. Jacobson. Human P2Y6 receptor: Molecular modeling
leads to the rational design of a novel agonist based on a unique conformational
preference. J. Med. Chem. 2005; 48:8108-8111.
3. K.A. Jacobson, L. Mamedova, J.V. Bhalchandra, P. Besada, S. Costanzi.
Molecular Recognition at Adenine Nucleotide (P2) Receptors in Platelets Seminars
in Thrombosis and Hemostasis. 2005; 31:N2:205-216.
4. Y.C. Kim, J.S. Lee, K. Sak, F. Marteau, L. Mamedova, J.M. Boeynaems, K.A.
Jacobson. Synthesis of pyrodoxal phosphate derivatives with antagonist activity at
the P2Y13 receptor. Biochem. Pharmacol. 2005; 70:266-274.
5. V. Shneyvays, D. Leshem, T. Zinman, L.K. Mamedova, KA. Jacobson, A.
Shainberg. Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte
homeostasis following mitochondrial respiratory chain injury. Am. J. Physiol. Heart
Circ. Physiol. 2005; 288:2792-2801.
6. P. Besada, L. Mamedova, C.J. Thomas, S. Costanzi and K.A. Jacobson. Design
and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of
structurally diverse functionality. Org. Biomol. Chem. 2005; 3:2016-2025.
2004
1. L.K. Mamedova, B.V. Joshi Z-G Gao, I. Kügelgen, K.A. Jacobson. Diisothiocyanate
derivatives as potent, noncompetitive inhibitors of P2Y6 nucleotide receptors.
Biochem. Pharmacol. 2004; 67:1763-1770.
2. Z-G.Gao, L.K. Mamedova, P. Chen, K.A. Jacobson. 2-Substituted adenosinederivatives: Affinity and efficacy are four subtypes of human adenosine
receptors. Biochem. Pharmacol. 2004; 68:1985-1993.
3. Z-G. Gao, L. Mamedova, S. Tchilibon, A.S. Gross, K.A. Jacobson. 2,2Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting
nucleotide binding. Biochem. Pharmacol. 2004; 68:231-237.
4. Z. Gao, L. Jeong, H. Moon, H. Kim, W. Choi, D. Shin, E. Elhalem, M. Comin, N.
Melman, L. Mamedova, A. Gross, J. Rodriguez, K. Jacobson. Structural
deterinants of efficacy at A3 adenosine receptors. Modification of the ribose moiety.
Biochem. Pharmacol. 2004; 67:893-901.
5. N. Tribulova, V. Shneyvays, L.K. Mamedova, S. Moshel, A.Shainberg, M.
Manoach, Weismann, S. Kostin. Enhanced connexin-43 and α-sarcomeric actin
expression in cultured heart myocytes exposed to triiodo-L-thyronine. J. Mol. Hist.
2004; 35:63-470.
6. S. Costanzi, L. Mamedova, Z. Gao and K.A. Jacobson. Architecture of P2Y
nucleotide receptors: structural comparison based on sequence analysis,
Mutagenesis, and homology modeling. J. Med. Chem. 2004; 47(22):5393-5404.
2003
1. L.K. Mamedova, V.Shneyvays, A.Katz and A. Shainberg. Mechanism of glycogen
supercompensation in rat skeletal muscle cultures: Mol. Cell. Biochem. 2004;
250:11-19.
2. A. Vigoda, L.K. Mamedova, V. Shneyvays, A. Katz and A. Shainberg. Glycogen
metabolism in rat heart muscle cultures after hypoxia. Mol. Cell. Biochem. 2003;
254:311-318.