1. L.K. Mamedova, R. Wang, P. Besada, B. . Liang, K. A. Jacobson. Attenuation of
Apoptosis in vitro and Ischemia/Reperfusion Injury in vivo in Mouse Skeletal Muscle
by P2Y6 Receptor Activation. Pharmacological Research. Biochem
1. L.K. Mamedova, Z-G Gao and K.A. Jacobson. ADP Regulates Death and Survival
in Astrocytes by Activating P2Y1 and P2Y12 Receptors. Biochem. Pharmacol. 2006;
2. P. Besada, L.K. Mamedova, K.K. Palaniappan, Z-G-Gao, B.V. Joshi, L.S. Jeong,
M.M. Civan, K.A. Jacobson. Nucleoside prodrugs of A3 adenosine receptor
agonists and antagonists. Col. Czechoslovak Chem. Com. 2006; 912-28.
3. N. Erkasap, M. Ikizler, V. Shneyvays, T. Zinman, L.K. Mamedova, R. Uyar, A.
Shainberg. Leptin protects the cardiac myocyte cultures from hypoxic damage. Life
sci. 2006; 78:1098-1102.
4. K.A. Jacobson, S.Costanzi, J. Bhalchandra, P. Besada, D.H. Shin, H.J. Ko, A.
Ivanov, L. Mamedova. Agonists and antagonists for P2 receptors. Purinergic
signalling in neuronglia interactions. Wiley, Chichester. Novartis Foundation
Symposium UK. 2006; 276:58-72.
5. Z.G. Gao, H.T. Duong, T. Sonin, S.K. Kim, P. Rompaey, S. Calenbergh, L.
Mamedova, L.S. Jeong, H.O. Kim, M. J. Kim, A.Y. Kim, B.T. Liang, K.A. Jacobson.
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using
tailored nucleoside agonists. J. Med. Chem. 2006; 49:2689 -2702.
1. L. Mamedova, V. Capra, M.R. Accomazo, Z.G. Gao, S. Ferrario, M. Fumagalli,
M.P. Abbracchio, G.E. Rovati, K.A. Jacobson. CysLT1 leukotriene receptor
antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem.
Pharmacol. 2005; 71:115-125.
2. S. Costanzi, J. Bhalchandra, S.. Maddileti, L. Mamedova, M.J. Gonzalez-Moa, V.E.
Marquez, T.K. Harden, K.A. Jacobson. Human P2Y6 receptor: Molecular modeling
leads to the rational design of a novel agonist based on a unique conformational
preference. J. Med. Chem. 2005; 48:8108-8111.
3. K.A. Jacobson, L. Mamedova, J.V. Bhalchandra, P. Besada, S. Costanzi.
Molecular Recognition at Adenine Nucleotide (P2) Receptors in Platelets Seminars
in Thrombosis and Hemostasis. 2005; 31:N2:205-216.
4. Y.C. Kim, J.S. Lee, K. Sak, F. Marteau, L. Mamedova, J.M. Boeynaems, K.A.
Jacobson. Synthesis of pyrodoxal phosphate derivatives with antagonist activity at
the P2Y13 receptor. Biochem. Pharmacol. 2005; 70:266-274.
5. V. Shneyvays, D. Leshem, T. Zinman, L.K. Mamedova, KA. Jacobson, A.
Shainberg. Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte
homeostasis following mitochondrial respiratory chain injury. Am. J. Physiol. Heart
Circ. Physiol. 2005; 288:2792-2801.
6. P. Besada, L. Mamedova, C.J. Thomas, S. Costanzi and K.A. Jacobson. Design
and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of
structurally diverse functionality. Org. Biomol. Chem. 2005; 3:2016-2025.
1. L.K. Mamedova, B.V. Joshi Z-G Gao, I. Kügelgen, K.A. Jacobson. Diisothiocyanate
derivatives as potent, noncompetitive inhibitors of P2Y6 nucleotide receptors.
Biochem. Pharmacol. 2004; 67:1763-1770.
2. Z-G.Gao, L.K. Mamedova, P. Chen, K.A. Jacobson. 2-Substituted adenosinederivatives: Affinity and efficacy are four subtypes of human adenosine
receptors. Biochem. Pharmacol. 2004; 68:1985-1993.
3. Z-G. Gao, L. Mamedova, S. Tchilibon, A.S. Gross, K.A. Jacobson. 2,2Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting
nucleotide binding. Biochem. Pharmacol. 2004; 68:231-237.
4. Z. Gao, L. Jeong, H. Moon, H. Kim, W. Choi, D. Shin, E. Elhalem, M. Comin, N.
Melman, L. Mamedova, A. Gross, J. Rodriguez, K. Jacobson. Structural
deterinants of efficacy at A3 adenosine receptors. Modification of the ribose moiety.
Biochem. Pharmacol. 2004; 67:893-901.
5. N. Tribulova, V. Shneyvays, L.K. Mamedova, S. Moshel, A.Shainberg, M.
Manoach, Weismann, S. Kostin. Enhanced connexin-43 and α-sarcomeric actin
expression in cultured heart myocytes exposed to triiodo-L-thyronine. J. Mol. Hist.
2004; 35:63-470.
6. S. Costanzi, L. Mamedova, Z. Gao and K.A. Jacobson. Architecture of P2Y
nucleotide receptors: structural comparison based on sequence analysis,
Mutagenesis, and homology modeling. J. Med. Chem. 2004; 47(22):5393-5404.
1. L.K. Mamedova, V.Shneyvays, A.Katz and A. Shainberg. Mechanism of glycogen
supercompensation in rat skeletal muscle cultures: Mol. Cell. Biochem. 2004;
2. A. Vigoda, L.K. Mamedova, V. Shneyvays, A. Katz and A. Shainberg. Glycogen
metabolism in rat heart muscle cultures after hypoxia. Mol. Cell. Biochem. 2003;