UNIVERSITE
BLAISE-PASCAL
UNIVERSITE
D’AUVERGNE
ECOLE DOCTORALE DES SCIENCES DE LA VIE ET DE LA SANTE
Laboratoire « Microorganismes : Génome & Environnement »
LMGE, UMR CNRS 6023
CONFERENCE
Aquatic viruses: manipulators of host
metabolism and reservoir of new genes
Hiroyuki OGATA
Information Génomique et Structurale
CNRS-UPR2589, Marseille
Mercredi 26 Novembre 2008
14:15 h
Amphi Enseignement Biologie Végétale, à côté du Bâtiment du LMGE
(Biologie A, N° 4 sur le plan http://www.univ-bpclermont.fr/IMG/pdf/ubpplan-cezeaux.pdf)
Contact : Télesphore SIME-NGANDO
Complexe Scientifique des Cézeaux - 63177 AUBIERE Cedex - FRANCE
Tél 33 (0) 4 73 40 78 36 Fax 33 (0) 4 73 40 76 70
Telesphore.sime-ngando@univ-bpclermont.fr
UNIVERSITE
BLAISE-PASCAL
UNIVERSITE
D’AUVERGNE
ECOLE DOCTORALE DES SCIENCES DE LA VIE ET DE LA SANTE
Résumé de la Conférence
Aquatic viruses: manipulators of host metabolism and reservoir of new genes
Hiroyuki Ogata (IGS, CNRS-UPR2589, Marseille)
Recent discoveries of several “host-like” genes in aquatic viruses begin to uncover a
potentially large spectrum of viral strategies in host manipulation. In my talk, I’ll first
present a couple of interesting such cases that we recently encountered: (1) The nblA,
encoding light-harvesting antenna degradation enzyme, found in the Ma-LMM01 phage
infecting the toxic cyanobacteria Microcystis aeruginosa, and (2) a series of sphingolipid
biosynthesis enzyme genes found in Emiliania huxleyi viruses, very likely transferred
from their eukaryotic host microalgae. Next, despite the possibly important role of
horizontal gene transfer (HGT) in viral evolution, our bioinformatics results suggest that
“host-to-virus” HGTs are not as frequent as often thought, leading to the idea that the
virosphere is a huge reservoir of novel genes unique to viruses. Finally, I’ll present our
new bioinformatics approach (“phylogenetic mapping”), which revealed the abundance
of the giant Mimivirus families in oceanic environments, as a way to characterize the yet
uncovered virosphere.
References:
1. Ogata H, Claverie J.-M. How to infect a Mimivirus. Science 321, 1305-1306 (2008).
2. Monier A., Claverie J.-M., Ogata H. Taxonomic distribution of large DNA viruses in
the sea. Genome Biol., 9, R106 (2008)
3. Yoshida T., Nagasaki K., Takashima Y., Shirai Y., Tomaru Y., Takao Y., Sakamoto
S., Hiroishi S., Ogata H. Ma-LMM01 infecting toxic Microcystis aeruginosa illuminates
diverse cyanophage genome strategies. J. Bacteriol., 190, 1762-1772 (2008).
4. Monier A., Claverie J.-M., Ogata H. Horizontal gene transfer and nucleotide
compositional anomaly in large DNA viruses. BMC Genomics, 8, 456 (2007).
5. Ogata H., Claverie J.-M. Unique genes in giant viruses: regular substitution pattern
and anomalously short size. Genome Res. 17, 1657-1664 (2007).
Complexe Scientifique des Cézeaux - 63177 AUBIERE Cedex - FRANCE
Tél 33 (0) 4 73 40 78 36 Fax 33 (0) 4 73 40 76 70
Telesphore.sime-ngando@univ-bpclermont.fr