OUTLINE for “The Cornea, the Optic Nerve and Glaucoma: What gives ?”
I.
Review of ocular biomechanical properties with regard to glaucoma
A. Central Corneal Thickness
1) Liu J, Roberts CJ. Influence of corneal biomechanical properties on
intraocular pressure measurement: quantitative analysis. J Cataract Refract
Surg 2005
2) Pepose J et al. Changes in corneal biomechanics and intraocular pressure
following LASIK using static, dynamic, and noncontact tonometry. Am J
Ophthalmol 2007.
3) Ehlers N et al. Applananation tonometry and central corneal thickness. Acta
Ophthalmol (Copenh). 1975 ;53(1):34-43.
4) Francis BA et al. (Los Angeles Latino Eye Study Group.) Effects of corneal
thickness, corneal curvature, and intraocular pressure level on Goldmann
applanation tonometry and dynamic contour tonometry. Ophthalmology
2007.
B. Corneal hysteresis and corneal resistance factor (obtained by the Ocular Response
Analyzer)
1) Congdon NG et al. Central corneal thickness and corneal hysteresis
associated with glaucoma damage. Am J Ophthalmol 2006
2) Koetcha A et al. Corneal thickness- and age-related biomechanical
properties of the cornea measured with the ocular response analyzer. IOVS
2006
C. Ocular Pulse Amplitude
1) Bayerle-Eder et al. Effect of a nifedipine induced reduction in blood
pressure on the association between ocular pulse amplitude and ocular
fundus pulsation amplitude in systemic hypertension. Br J Ophthalmol 2005
2) Punjabe OS et al. Intraocular pressure and ocular pulse amplitude
comparisons in different types of glaucoma using dynamic contour
tonometry. Curr Eye Res. 2006 Oct;31(10):851-62.
D. Optic nerve head biomechanics in glaucoma
1) Sigal IA et al. Factors influencing optic nerve head biomechanics. IOVS
2005
2) Burgoyne CF et al. The optic nerve as a biomechanical structure. Prog Retin
Eye Res 2005
II.
Influence of ocular biomechanical factors on IOP measurement
A. Central corneal thickness
1) Doughty MJ, Zaman ML. Human corneal thickness and its impact on
intraocular pressure measures: a review and meta-analysis approach. Surv
Ophthalmol 2000
B. Influence of other corneal factors on IOP
1) Sullivan-Mee et al. Factors influencing intraocular pressure measurement
agreement between Goldmann applanation, Pascal Dynamic Contour, and
Ocular Response Analyzer tonometers. J Glaucoma 2012, in press.
C. Can ocular biomechanical factor influence on IOP measurement be
overcome/minimized ?
1) Dynamic contour tonometry
a) Boehm AG et al. Dynamic contour tonometry in comparison to
intracameral IOP measurements. Invest Ophthalmol Vis Sci.
200849(6):2472-7.
b) Sullivan-Mee et al. Clinical comparison of Pascal dynamic contour
tonometry and Goldmann applanation tonometry in asymmetric openangle glaucoma. J Glaucoma 2007.
2) Ocular Response Analyzer
a) Luce DA. Determining in vivo biomechanical properties of the cornea
with an ocular response analyzer. J Cataract Refract Surg.
2005;31(1):156-62.
3) Goldmann applanation tonometry correction factors
a) Elsheikh A et al. Multiparameter correction equation for Goldmann
applanation tonometry. Optom Vis Sci. 2011;88(1):E102-12.
III.
Ocular biomechanical factor associations with glaucoma independent from IOP effects
1) Glaucoma risk associated with central corneal thickness
a) Gordon MO et al. OHTS. Baseline factors that predict the onset of
primary open-angle glaucoma. Arch Ophthalmol 2002.
b) Jonas JB et al. Central corneal thickness correlated with glaucoma
damage and rate of progression. Invest Ophthalmol Vis Sci
2005;46(4):1269-74.
c) Chauhan BC et al. Central corneal thickness and progression of the
visual field and optic disc in glaucoma. Br J Ophthalmol. 2005
Aug;89(8):1008-12.
2) Glaucoma risk associated with corneal hysteresis
a) Congdon NG et al. Central corneal thickness and corneal hysteresis
associated with glaucoma damage. Am J Ophthalmol 2006
b) Sullivan-Mee et al. Ocular Response Analyzer in subjects with and
without glaucoma. Optom Vis Sci. 2008;85(6):463-70.
c) Anand A et al. Corneal hysteresis and visual field asymmetry in open
angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6514-8.
IV.
Posterior segment structures involved in optic nerve biomechanics
A. Changes in optic nerve head tissues in glaucoma
1) Girard MJ et al. Biomechanical changes in the sclera of monkey eyes
exposed to chronic IOP elevations. Invest Ophthalmol Vis Sci. 2011 Jul
29;52(8):5656-69.
2) Roberts MD et al. Changes in the biomechanical response of the optic nerve
head in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2010
Nov;51(11):5675-84.
3) Downs JC et al. Mechanical environment of the optic nervehead in
glaucoma. Optom Vis Sci. 2008 Jun;85(6):425-35.
B. Clinical methods to examine optic nerve head biomechanics
1) Park SC et al. Enhanced depth imaging optical coherence tomography of
deep optic nerve complex structures in glaucoma. Ophthalmology. 2012
Jan;119(1):3-9.
2) Yang H et al. Spectral Domain Optical Coherence Tomography (SDOCT)
Enhanced Depth Imaging (EDI)of the Normal and Glaucomatous Nonhuman Primate (NHP) Optic Nerve Head (ONH). Invest Ophthalmol Vis
Sci. 2011 Dec 9. [Epub ahead of print]
3) Lee EY et al. Three-Dimensional Evaluation of the Lamina Cribrosa Using
Spectral-Domain Optical Coherence Tomography in Glaucoma. Invest
Ophthalmol Vis Sci 2012;53 198-204