ANNEMIEKE W. PLUG-DE MAGGIO
6465 NE 186th street
Kenmore, WA 98028
(425) 398 0650
ademaggi@fhcrc.org
EDUCATION:
Ph.D., University of Utrecht, Department of Human Molecular Genetics, The Netherlands, 1997
M.S., Agricultural University of Wageningen, The Netherlands, 1995
WRITING AND EDITING SKILLS:
Completed Certificate Program in Technical and Science Communication, University of Washington. 2003.
Freelance medical and science writer/editor, 2002-present.
Member American Medical Writers Association.
COMPUTER SKILLS:
Microsoft Office, Adobe PhotoShop, Adobe FrameMaker, Deneba Canvas.
TEACHING SKILLS:
Adjunct-faculty Seattle University, 2002.
RESEARCH EXPERIENCE:
RESEARCH ASSOCIATE, September 1999 to Present
Division of Cancer Biology, Fred Hutchinson Cancer
Research Center, Seattle, Washington.
POSTDOCTORAL ASSOCIATE, September 1998 to August 1999
Vollum Institute, Oregon Health Sciences University,
Portland, Oregon.
POSTDOCTORAL ASSOCIATE, April 1997 to August 1998
Department of Genetics, Yale University School of
Medicine, New Haven, Connecticut.
PREDOCTORAL ASSOCIATE, January 1995 to March 1997
Department of Genetics, Yale University School of
Medicine, New Haven, Connecticut.
PUBLICATIONS:
Plug-DeMaggio, A.W, Sundsvold, T, Koop, J.I, Klingelhutz, A.J and McDougall, J.K. HPV-induced defects in the
mitotic spindle checkpoint. Submitted (2003).
Plug-DeMaggio, A.W, Sundsvold, T, Koop, J.I, Klingelhutz, A.J and McDougall, J.K. Telomere-dysfunction and
chromosomal reaarangments in HPV 16E6 expressing cells. Submitted (2003).
Plug-DeMaggio, A.W., McDougall, J. The Human Papillomavirus type 16 E6
oncogene induces premature mitotic chromosome segregation. Oncogene 21:750713. 2002.
Smith L, Plug A, Thayer M. Delayed replication timing leads to delayed mitotic chromosome condensation and
chromosomal instability of chromosome translocations.
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13300-5.
Walpita D, Plug AW, Neff NF, German J, Ashley T. Bloom's syndrome protein, BLM, colocalizes with replication
protein A in meiotic prophase nuclei of mammalian spermatocytes. Proc Natl Acad Sci U S A. 1999 May
11;96(10):5622-7.
Plug AW, Peters AH, Keegan KS, Hoekstra MF, de Boer P, Ashley T.
Changes in protein composition of meiotic nodules during mammalian meiosis. J Cell Sci. 1998 Feb;111 ( Pt
4):413-23.
Flaggs G, Plug AW, Dunks KM, Mundt KE, Ford JC, Quiggle MR, Taylor EM, Westphal CH, Ashley T, Hoekstra
MF, Carr AM. Atm-dependent interactions of a mammalian chk1 homolog with meiotic
chromosomes. Curr Biol. 1997 Dec 1;7(12):977-86.
Plug AW, Peters AH, Xu Y, Keegan KS, Hoekstra MF, Baltimore D, de Boer P,
Ashley T. ATM and RPA in meiotic chromosome synapsis and recombination.
Nat Genet. 1997 Dec;17(4):457-61.
Ashley T, Plug A. Caught in the act: deducing meiotic function from protein immunolocalization.
Curr Top Dev Biol. 1998;37:201-39. Review.
Peters AH, Plug AW, de Boer P. Meiosis in carriers of heteromorphic bivalents: sex differences and
implications for male fertility. Chromosome Res. 1997 Aug;5(5):313-24.
Plug AW, Clairmont CA, Sapi E, Ashley T, Sweasy JB. Evidence for a role for DNA polymerase beta in
mammalian meiosis. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1327-31.
Peters AH, Plug AW, van Vugt MJ, de Boer P. A drying-down technique for the spreading of mammalian meiocytes
from the male and female germline. Chromosome Res. 1997 Feb;5(1):66-8.
Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T,
Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells.
Cell. 1997 Jan 24;88(2):265-75.
Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G,
Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hoekstra MF.
The Atr and Atm protein kinases associate with different sites along
meiotically pairing chromosomes. Genes Dev. 1996 Oct 1;10(19):2423-37.
Morse DC, Plug A, Wesseling W, van den Berg KJ, Brouwer A.
Persistent alterations in regional brain glial fibrillary acidic protein and
synaptophysin levels following pre- and postnatal polychlorinated biphenyl
exposure. Toxicol Appl Pharmacol. 1996 Aug;139(2):252-61.
Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM,
Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM. Involvement of mouse Mlh1 in DNA mismatch repair and
meiotic crossing over. Nat Genet. 1996 Jul;13(3):336-42.
Plug AW, Xu J, Reddy G, Golub EI, Ashley T. Presynaptic association of Rad51 protein with selected sites in
meiotic chromatin. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5920-4.
Kovalenko OV, Plug AW, Haaf T, Gonda DK, Ashley T, Ward DC, Radding CM,
Golub EI. Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination
protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2958-63.
Ashley T, Plug AW, Xu J, Solari AJ, Reddy G, Golub EI, Ward DC.
Dynamic changes in Rad51 distribution on chromatin during meiosis in male and
female vertebrates. Chromosoma. 1995 Oct;104(1):19-28.
Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA,
Yu J, Ashley T, Arnheim N, et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal
chromosome synapsis in meiosis. Cell. 1995 Jul 28;82(2):309-19.