Potential Symposium Speakers Jack Szostak, Ph.D. Professor of Genetics Department of Genetics Howard Hughes Medical Institute and Department of Molecular Biology Harvard Medical School Wellman Building, 9th Floor 50 Blossom Street Boston, MA 02114 Tel: (617) 726-5981 Email: szostak@molbio.mgh.harvard.edu My laboratory is using in vitro selection and directed evolution to explore sequence space for functional RNA, DNA and protein sequences. Melvin Simon, Ph.D. Professor of Biological Sciences Division of Biology, 156-29 California Institute of Technology 1200 E. California Blvd. Pasadena, CA 91125 626) 395-3944 Email:simonm@caltech.edu We are interested in how cells respond to changes in their external chemical and physical environments. Leslie Orgel, Ph.D. Professor, Chemical Evolution Lab Salk Institute for Biological Studies Post Office Box 85800 San Diego, California 92186-5800 858-453-4100 Email: orgel@salk.edu His focus is on discovering the chemical reactions that might have occurred on primitive Earth, particularly those that may have led to the origins of life. During its studies, Orgel’s lab came across an economical way to make cytosine arabinoside, a compound that is one of today’s most commonly used anti-cancer agents. Gerald Joyce, M.D., Ph.D. Departments of Chemistry and Molecular Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 858-784-2017 Email: gjoyce@scripps.edu Inspired by what Darwinian evolution has accomplished in nature, we strive to put those same forces to work in the laboratory to develop compounds that have practical benefit. Doug Melton, Ph.D. Department of Molecular and Cellular Biology Harvard University 7 Divinity Ave, Room 465 Cambridge MA, 02138 Phone: (617) 495-1812 Email: dmelton@biohp.harvard.edu Our laboratory is investigating the normal development of the pancreas in order to understand how islets and ß cells are produced Tim Mitcheson, Ph.D. Institute of Chemistry and Cell Biology Harvard Medical School 250 Longwood Ave SGMB 604 Boston, MA 02115 Tel: (617) 432-3805 Email: timothy_mitchison@hms.harvard.edu My cell biology lab is interested in the structure, dynamics, and function of the cytoskeleton. We use imaging-based assays in living cells and in vitro extracts, in conjunction with molecular biology and biochemical fractionation approaches. Daphne Preuss, Ph.D. Department of Molecular Genetics and Cell Biology University of Chicago 1103 E. 57th Street Chicago, Illinois 60637 Phone: 773-702-9558 Email: dpreuss@midway.uchicago.edu Our research is aimed at identifying components that mediate inheritance, from the gene products that control fertilization to those that regulate DNA transmission. Andrew Murray, Ph.D. Professor of Molecular and Cellular Biology Director, Bauer Center for Genomics Research Harvard University Bio Labs, Room 3000 16 Divinity Ave. Cambridge MA 02138 Phone: (617) 496-1350 Email: amurray@mcb.harvard.edu We are interested in the general principles that underlie the function and evolution of cells, as revealed by studying the transmission of genetic information during cell division and how cells evolve in response to selective pressure. Marc W. Kirschner, Ph.D. Professor of Systems Biology Department of Systems Biology Harvard Medical School 240 Longwood Avenue Boston, MA 02115 Phone: 617-432-2250 E-mail: marc@hms.harvard.edu Dr. Kirschner’s laboratory investigates three broad, diverse areas: regulation of the cell cycle, the role of cytoskeleton in cell morphogenesis, and mechanisms of establishing the basic vertebrate body plan. R Bruce Nicklas, Ph.D. A. S. Pearse Professor and Professor of Cell Biology Duke University Department of Biology Box 90338 Durham, NC 27708 919-613-8196 Email: bnicklas@duke.edu Morphogenesis at the cellular level. We push chromosomes around by micromanipulation to learn more about chromosome movement in mitosis. David Botstein, Ph.D. Anthony B. Evnin Professor of Genomics Director, Lewis-Sigler Institute for Integrative Genomics 140 Carl Icahn Laboratory Princeton University Washington Road Princeton, NJ 08544 609-258-7005 Email: botstein@princeton.edu Administrative Assistant: Faith Bahadurian 609-258-3731 (phone). faithb@princeton.edu Research areas: (1) genome-wide studies of gene expression through the life cycle and experimental evolution of budding yeast (Saccharomyces cerevisiae); (2) gene expression studies of tumor cell biology in models of metastasis; and (3) quantitative analysis and intuitive display of genome-scale biological information. Matthew Scott, Ph.D. Professor of Developmental Biology & Genetics Developmental Biology Clark Center W252 Stanford University Stanford, CA 94305-5439 (650) 725-7680 Email:scott@cmgm.stanford.edu Matthew Scott is investigating genes that regulate embryonic development and cancer, including genes that turn other genes on and off and genes that code for components of signaling systems. Ajit Varki, Ph.D. Professor of Medicine Co-Director, Glycobiology Research and Training Center Associate Dean for Physician-Scientist Training Glycobiology Research and Training Center University of California, San Diego Dept. of Cellular and Molecular Medicine-East, Mail Code 0687 9500 Gilman Drive La Jolla CA 92093-0687 (858) 534-2214 Email: a1varki@ucsd.edu Dr. Varki's research interests are currently focused on a family of sugars called the Sialic Acids, and their roles in biology, evolution and disease. Neil Shubin, Ph.D. Professor and Chair Department of Organismal Biology and Anatomy The University of Chicago 5801 South Ellis, Chicago, IL 60637 773-834-7472 Email: nshubin@uchicago.edu I seek to understand the mechanisms behind the evolutionary origin of new anatomical features and faunas. Howard Berg, Ph.D. Herchel Smith Professor of Physics and Professor of Molecular and Cellular Biology Harvard University Dept. of Molecular & Cellular Biology 16 Divinity Ave, Room 3063A Cambridge MA, 02138 (617) 495-0924 Email: hberg@mcb.harvard.edu We study bacteria, the simplest free-living single-celled organisms. We are interested in how they sense changes in their environment, analyze sensory data, and respond in a purposeful manner. Our quest is an understanding of behavior at the molecular level. Elizabeth Blackburn, Ph.D. Professor, Department of Biochemistry and Biophysics. Biochemistry and Biophysics University of California, San Francisco Box 2200, UCSF San Francisco, CA 94143-2200 415-476-4912 Email: telomer@itsa.ucsf.edu The research program of the laboratory focuses on telomeres, the structures stabilizing the ends of the eukaryotic chromosomes, and the enzyme telomerase. Paul Allen Co-Founder of Microsoft, Inc. One Microsoft Way Redmond, WA 98052-6399 Roy Parker, Ph.D. Regents Professor-Hughes Molecular & Cellular Biology University of Arizona Building: Life Sciences South Room: 533A Phone: 621-9347 Email: rrparker@u.arizona.edu The Parker Lab studies cytoplasmic RNA metabolism in the budding yeast Saccharomyces cerevisiae. Nancy Moran, Ph.D. Ecology and Evolutionary Biology University of Arizona P.O. Box 210088 Tucson, AZ 621-3581 Email: nmoran@u.arizona.edu Currently, Nancy Moran's primary research focus concerns the genome level evolution of prokaryotic, mutualistic endosymbionts within animal hosts, especially insects. Lawrence Hurley, Ph.D. Professor, Medicinal Chemistry-Pharmaceutical Sciences Professor, Medicinal Chemistry-Pharmacology & Toxicology College of Pharmacy Pharmacology And Toxicology Leon Levy- Cancer Center Room 4949 520-626-5622 Email: hurley@pharmacy.arizona.edu The overall objective of the research projects in my laboratory is to design and develop novel antitumor agents that will extend the productive lives of patients who have cancer. Carol Barnes, Ph.D. Psychology Department Life Sciences North P.O. Box 210221 University of Arizona 520-626-2616 Email: carol@nsma.arizona.edu The central goal of my research and teaching program is the question of how the brain changes during the aging process and the functional consequences of these changes on information processing and memory in the elderly. Bruce McNaughton, Ph.D. Professor of Psychology and ARL Division of Neural Systems, Memory & Aging; Chair, Committee on Neuroscience Life Sciences North P.O. Box 210221 Tel: 626-2615 Email: bruce@nsma.arizona.edu My research and academic interests focus primarily on how the brain computes. In particular, I am interested in brain mechanisms of learning and memory. Charles M. Higgins, Ph.D. Assistant Professor, of Electrical and Computer Engineering Assistant Professor, Neurobiology P.O. Box 210104 (520) 621-6604 Email: higgins@ece.arizona.edu I work in the field of Neuromorphic Engineering, in which insight from neurobiology is used as inspiration for engineering VLSI designs