Department of Physics and Materials Science
Centre Of Super-Diamond and Advanced Films (COSDAF)
Joint Seminar
Fluids and Surfaces at Micro/Nanoscale: New Opportunities
for Biomaterials
Prof Xingyu Jiang
National Center for NanoScience and Technology, China
Date: 10 December 2009 (Thursday)
Time: 2:45 pm (tea reception: 2:30 pm)
Venue: P4701
Academic Building
City University of Hong Kong
Enquiry: 2788-7829
Fluids and Surfaces at /MicroNanoscale: New Opportunities for
Biomaterial
Prof Xingyu Jiang
National Center for NanoScience and Technology, China
ABSTRACT
Our group research focuses on the modification of surfaces and interfaces for biomaterials.
We invented a method for the reversible control of the adhesion of mammalian cells on a
molecularly well-defined surface of mixed self-assembled monolayers (SAMs) presenting
azobenzene groups terminated in GRGDS peptides in a background of hexaethyleneglycolterminated thiols (EG6).
To control the adhesion and migration of mammalian cells on surfaces, we established a
method for using EG6 to form a SAM on a gold surface, and a PDMS stamp with embedded
microfluidic channels to carry out selective electrochemical desorption of EG6 from the gold
surface. This procedure allowed parts of the inert surface to promote the adsorption of
proteins and the adhesion of cells. Each of these individually addressable microchannels
could deliver one cell type to activated regions of the surface, resulting in a pattern of
multiple types of cells on the surface.
We used functional gold nanoparticles in chemical analysis. We developed a visual detection
method for Cu2+ by azide-/ alkyne-functionalized gold nanoparticles (Au NPs) in aqueous
solution via click chemistry. This process can be monitored by the naked eye, from red to
blue. This method can be potentially extended to assays without the need for bulky
equipments. In the following research, the assay system will be applied in biochemical field.
References
D. Liu, Y. Xie, H. Shao, X. Jiang, Angew. Chem. Int. Edit. 48, 4406 (2009).
D. Yang, X. Niu., Y. Liu, Y. Wang, X. Gu, L. Song, R. Zhao, L. Ma, Y. Shao, X. Jiang, Adv.
Mater., 20 (24), 4770-4775 (2008).
D. Liu, Y. Xie, H. Shao, X. Jiang, Prog. Chem. 19, 1965 (2007).
Y. Li, B. Yuan, H. Ji, D. Han, S. Chen, F. Tian, X. Jiang, Angew. Chem. Int. Edit. 46, 1094
(2007).
Y. Zhou, S. X. Wang, K. Zhang, X. Jiang, Angew. Chem. Int. Edit. 47, 7454 (2008).
G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, D. E. Ingber, Annu. Rev. Biomed. Eng.
3, 335 (2001).